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https://www.readbyqxmd.com/read/29306692/neurocognitive-features-in-clinical-subgroups-of-bipolar-disorder-a-meta-analysis
#1
REVIEW
Emre Bora
OBJECTIVE: There is a significant cognitive heterogeneity in bipolar disorder (BD). The aim of this systematic review was to examine the potential distinctive neuropsychological of features of clinical subgroups of BD. A literature search investigating cognitive differences between potential subtypes of BD was conducted. METHODS: It was possible to conduct a meta-analysis of studies investigating the relationship between cognitive deficits and subgroups of DSM-IV BD (type I (BD-I) and type II (BD-II)), subgroups based on history of psychosis (PBD and NPBD)...
December 29, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/29295889/the-actin-cytoskeleton-and-actin-based-motility
#2
REVIEW
Tatyana Svitkina
SUMMARYThe actin cytoskeleton-a collection of actin filaments with their accessory and regulatory proteins-is the primary force-generating machinery in the cell. It can produce pushing (protrusive) forces through coordinated polymerization of multiple actin filaments or pulling (contractile) forces through sliding actin filaments along bipolar filaments of myosin II. Both force types are particularly important for whole-cell migration, but they also define and change the cell shape and mechanical properties of the cell surface, drive the intracellular motility and morphogenesis of membrane organelles, and allow cells to form adhesions with each other and with the extracellular matrix...
January 2, 2018: Cold Spring Harbor Perspectives in Biology
https://www.readbyqxmd.com/read/29282470/efficacy-and-safety-of-transcranial-direct-current-stimulation-as-an-add-on-treatment-for-bipolar-depression-a-randomized-clinical-trial
#3
Bernardo Sampaio-Junior, Gabriel Tortella, Lucas Borrione, Adriano H Moffa, Rodrigo Machado-Vieira, Eric Cretaz, Adriano Fernandes da Silva, Renério Fraguas, Luana V Aparício, Izio Klein, Beny Lafer, Stephan Goerigk, Isabela Martins Benseñor, Paulo Andrade Lotufo, Wagner F Gattaz, André Russowsky Brunoni
Importance: More effective, tolerable interventions for bipolar depression treatment are needed. Transcranial direct current stimulation (tDCS) is a novel therapeutic modality with few severe adverse events that showed promising results for unipolar depression. Objective: To determine the efficacy and safety of tDCS as an add-on treatment for bipolar depression. Design, Setting, and Participants: A randomized, sham-controlled, double-blind trial (the Bipolar Depression Electrical Treatment Trial [BETTER]) was conducted from July 1, 2014, to March 30, 2016, at an outpatient, single-center academic setting...
December 27, 2017: JAMA Psychiatry
https://www.readbyqxmd.com/read/29248821/psychometric-properties-of-the-well-being-index-who-5-spanish-version-in-a-sample-of-euthymic-patients-with-bipolar-disorder
#4
C M Bonnín, L N Yatham, E E Michalak, A Martínez-Arán, T Dhanoa, I Torres, C Santos-Pascual, E Valls, A F Carvalho, J Sánchez-Moreno, M Valentí, I Grande, D Hidalgo-Mazzei, E Vieta, M Reinares
BACKGROUND: The concept of well-being which focuses on positive emotions has received increased research attention. However, a consensus definition of this term is lacking. The Well-Being Index scale (WHO-5) is a generic, self-report scale that contains five Likert-type items to evaluate psychological well-being. This construct may provide a relevant outcome in bipolar disorder (BD) research and care beyond the rating of mood symptoms. Thus, in the current study, the psychometric properties of the WHO-5 Spanish version were assessed in a sample of euthymic patients with BD...
December 6, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/29245092/predictors-of-hospitalization-length-of-stay-among-re-admitted-treatment-resistant-bipolar-disorder-inpatients
#5
M Fornaro, F Iasevoli, S Novello, A Fusco, A Anastasia, D De Berardis, A Valchera, A de Bartolomeis
BACKGROUND: Hospitalization accounts for significant health care resource utilization for treatment-resistant Bipolar Disorder (BD), especially among frequent users of acute inpatient psychiatric units. Appraisal of the clinical features and predictive role of selected variables is therefore crucial in such population, representing the aim of the present research. METHODS: A hundred and nineteen BD inpatients with an established history of pharmacological treatment resistance for either mania or bipolar depression were classified as long hospitalization cases (LOS+) and their controls and compared against each other for a number of demographic, clinical, and psychopathological features...
December 7, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/29237066/early-motor-developmental-milestones-and-schizotypy-in-the-northern-finland-birth-cohort-study-1966
#6
Svetlana Filatova, Heli Koivumaa-Honkanen, Golam M Khandaker, Estelle Lowry, Tanja Nordström, Tuula Hurtig, Kristiina Moilanen, Jouko Miettunen
Delayed motor developmental milestones have been reported to be associated with schizophrenia in previous studies, but no study has examined the relationship between early motor developmental milestones and schizotypy. We have examined this relationship in a prospective birth cohort.In the Northern Finland Birth Cohort 1966, data on 9 early motor developmental milestones were collected prospectively from visits to child welfare centers, and data on adult schizotypy were collected through a questionnaire (N = 4557-4674)...
December 9, 2017: Schizophrenia Bulletin
https://www.readbyqxmd.com/read/29177955/a-randomized-double-blind-placebo-controlled-proof-of-concept-trial-of-creatine-monohydrate-as-adjunctive-treatment-for-bipolar-depression
#7
Ricardo Alexandre Toniolo, Michelle Silva, Francy de Brito Ferreira Fernandes, José Antonio de Mello Siqueira Amaral, Rodrigo da Silva Dias, Beny Lafer
Depressive episodes are a major cause of morbidity and dysfunction in individuals suffering from bipolar disorder. Currently available treatments for this condition have limited efficacy and new therapeutic options are needed. Extensive research in the pathophysiology of bipolar disorder points to the existence of mitochondrial and bioenergetic dysfunction. We hypothesized that creatine monohydrate, a nutraceutical that works as a mitochondrial modulator, would be effective as an adjunctive therapy for bipolar depression...
November 24, 2017: Journal of Neural Transmission
https://www.readbyqxmd.com/read/29167880/association-between-schizophrenia-related-polygenic-liability-and-the-occurrence-and-level-of-mood-incongruent-psychotic-symptoms-in-bipolar-disorder
#8
Judith Allardyce, Ganna Leonenko, Marian Hamshere, Antonio F Pardiñas, Liz Forty, Sarah Knott, Katherine Gordon-Smith, David J Porteous, Caroline Haywood, Arianna Di Florio, Lisa Jones, Andrew M McIntosh, Michael J Owen, Peter Holmans, James T R Walters, Nicholas Craddock, Ian Jones, Michael C O'Donovan, Valentina Escott-Price
Importance: Bipolar disorder (BD) overlaps schizophrenia in its clinical presentation and genetic liability. Alternative approaches to patient stratification beyond current diagnostic categories are needed to understand the underlying disease processes and mechanisms. Objective: To investigate the association between common-variant liability for schizophrenia, indexed by polygenic risk scores (PRSs), and psychotic presentations of BD. Design, Setting, and Participants: This case-control study in the United Kingdom used multinomial logistic regression to estimate differential PRS associations across categories of cases and controls...
November 22, 2017: JAMA Psychiatry
https://www.readbyqxmd.com/read/29156424/blink-reflex-under-external-emotional-stimuli-in-bipolar-i-and-ii-disorders
#9
Qisha Zhu, Jiawei Wang, Hongying Fan, Guorong Ma, Bingren Zhang, Chanchan Shen, Wei Wang
Bipolar disorder types I (BD I) and II (BD II) might present different cortico-brainstem circuit dysfunctions under external emotions, which might be reflected by the blink reflex. We therefore invited 32 BD I and 23 BD II patients, and 46 healthy volunteers to answer the Mood Disorder Questionnaire, the Hypomania Checklist-32, and the Plutchik - van Praag Depression inventory, and to undergo the blink reflex test under external emotions (emotional pictures plus sounds) of Disgust, Erotica, Fear, Happiness, and Sadness...
November 10, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/29127563/reasons-for-nonadherence-to-psychiatric-medication-and-cardiovascular-risk-factors-treatment-among-latino-bipolar-disorder-patients-living-in-puerto-rico-a-qualitative-study
#10
Sandra I Ralat, Colin A Depp, Guillermo Bernal
Latinos with bipolar disorder (BD) have a high rate of nonadherence to psychiatric medication and treatment for other medical conditions such as cardiovascular disease (CVD) risk factors than non-Latinos with BD. The aim of this study is to identify patients' perspectives on the reasons for nonadherence to psychiatric medication and for CVD risk factors conditions in outpatients with BD. Three focus group sessions were held for a total of 22 adults ranging from 23 to 60 years old. Participants had BD, Type I/II and CVD risk factors...
November 10, 2017: Community Mental Health Journal
https://www.readbyqxmd.com/read/29121879/hypnotic-susceptibility-and-affective-states-in-bipolar-i-and-ii-disorders
#11
Bingren Zhang, Jiawei Wang, Qisha Zhu, Guorong Ma, Chanchan Shen, Hongying Fan, Wei Wang
BACKGROUND: Highly hypnotizable individuals have impaired executive function, elevated motor impulsivity and increased emotional sensitivity, which are sometimes found in bipolar disorder patients. It is then reasonable to assume that certain aspects of hypnotic susceptibility differ with the types of bipolar disorder. METHODS: The Stanford Hypnotic Susceptibility Scale: Form C (SHSS:C) test, the Mood Disorder Questionnaire (MDQ), the Hypomanic Checklist-32 (HCL-32) and the Plutchick-van Praag Depression Inventory (PVP) were applied to 62 patients with bipolar I disorder, 33 bipolar II disorder, and 120 healthy volunteers...
November 9, 2017: BMC Psychiatry
https://www.readbyqxmd.com/read/29062369/evaluation-of-bipolar-disorder-in-several-relapses-over-time-using-generalized-estimating-equations
#12
Payam Amini, Roya Najafi-Vosough, Ali Ghaleiha, Hossein Mahjub
Objective: Bipolar disorder is defined as a common and severe chronic disorder that causes several problems in a person's psychosocial functioning. This study aimed at modeling the development of bipolar disorder episodes using its determinant risk factors over time. Method: This retrospective cohort study was conducted in Hamadan province, the West of Iran, from April 2008 to September 2014. In this study, 124 patients with bipolar disorder (both Type I and Type II) participated. All patients had experienced 4 relapses...
July 2017: Iranian Journal of Psychiatry
https://www.readbyqxmd.com/read/29054353/the-rate-of-radial-head-prosthesis-removal-or-revision-a-systematic-review-and-meta-analysis
#13
Amir R Kachooei, Aslan Baradaran, Mohammad H Ebrahimzadeh, C Niek van Dijk, Neal Chen
PURPOSE: We conducted a meta-analysis and systematic review with the primary objective to determine the overall incidence of radial head prosthesis removal or revision. Our secondary objectives addressed the incidence of removal or revision based on the type of prosthesis fixation (cemented, uncemented smooth stem, uncemented press-fit), material (metal, Vitallium, titanium, pyrocarbon), and design (short vs long stem and monopolar vs bipolar), and the reasons for prosthetic removal or revision...
October 18, 2017: Journal of Hand Surgery
https://www.readbyqxmd.com/read/28979648/screening-of-the-unrecognised-bipolar-disorders-among-outpatients-with-recurrent-depressive-disorder-a-cross-sectional-study-in-psychiatric-hospital-in-morocco
#14
Oneib Bouchra, Sabir Maria, Ouanass Abderazak
The bipolar disorder is often misdiagnosed in particular among outpatients with recurrent depression. Indeed, this work confirmed that the unrecognised bipolar disorder is common among depressed outpatients, which were younger, unemployed, single or divorced with a low socio-economic level. These socio-demographics data gives us an idea about the disability experienced by the unknown bipolar patients. Also, we demonstrate that the under-diagnosis bipolar disorder was associated with the earliest onset age of a depressive episode and it was more prevalent in depressed patients with suicidal ideation and suicide attempts...
2017: Pan African Medical Journal
https://www.readbyqxmd.com/read/28972930/insomnia-and-hypersomnia-in-major-depressive-episode-prevalence-sociodemographic-characteristics-and-psychiatric-comorbidity-in-a-population-based-study
#15
Pierre A Geoffroy, Nicolas Hoertel, Bruno Etain, Frank Bellivier, Richard Delorme, Frédéric Limosin, Hugo Peyre
OBJECTIVES: To examine (i) the frequency of different sleep complaints (early wake-up, trouble falling asleep, hypersomnia) and their co-occurrence and (ii) the sociodemographic characteristics and psychiatric comorbidity associated with each type of sleep profiles. METHODS: Data were drawn from the Wave 2 National Epidemiologic Survey on Alcohol and Related Conditions, a nationally representative survey of the US adult population (wave 1, 2001-2002; wave 2, 2004-2005)...
January 15, 2018: Journal of Affective Disorders
https://www.readbyqxmd.com/read/28968513/prevalences-of-autoimmune-diseases-in-schizophrenia-bipolar-i-and-ii-disorder-and-controls
#16
Laura Cremaschi, Mathias Kardell, Viktoria Johansson, Anniella Isgren, Carl M Sellgren, A Carlo Altamura, Christina M Hultman, Mikael Landén
Previous studies on the relationship between autoimmune diseases, schizophrenia, and bipolar disorder are mainly based on hospital discharge registers with insufficient coverage of outpatient data. Furthermore, data is scant on the prevalence of autoimmune diseases in bipolar subgroups. Here we estimate the self-reported prevalences of autoimmune diseases in schizophrenia, bipolar disorder type I and II, and controls. Lifetime prevalence of autoimmune diseases was assessed through a structured interview in a sample of 9076 patients (schizophrenia N = 5278, bipolar disorder type I N = 1952, type II N = 1846) and 6485 controls...
December 2017: Psychiatry Research
https://www.readbyqxmd.com/read/28966598/verbal-memory-impairment-in-patients-with-subsyndromal-bipolar-disorder
#17
Tomiki Sumiyoshi, Atsuhito Toyomaki, Naoko Kawano, Tomoko Kitajima, Ichiro Kusumi, Norio Ozaki, Nakao Iwata, Kazuki Sueyoshi, Kazuyuki Nakagome
BACKGROUNDS: Several domains of cognitive function, including learning memory and executive function, are impaired in mood disorders. Also, the relationship between disturbances of these two cognitive domains has been suggested. In line with the recent initiative to establish a standard measure of cognitive decline in bipolar disorder, the present study was conducted to (1) test the criterion-related validity and test-retest reliability of the California Verbal Learning Test (CVLT)-II Japanese version, and (2) determine if type of word learning tasks (i...
2017: Frontiers in Psychiatry
https://www.readbyqxmd.com/read/28949313/dyadic-adjustment-among-healthy-spouses-of-bipolar-i-and-ii-disorder-patients
#18
Aleksandra Arciszewska, Marcin Siwek, Dominika Dudek
BACKGROUND: The aim of the study was to investigate the total dyadic adjustment (including satisfaction, cohesion, consensus and affectional expression) among spouses of bipolar patients with I and II subtypes. SUBJECTS AND METHODS: 82 subjects (46 women/ 36men) were enrolled in the study - 50 spouses of bipolar I (BD I) patients and 32 spouses of bipolar II (BD II) patients. We used an interview, the Dyadic Adjustment Scale (DAS), and a questionnaire including questions concerning basic socio-demographic data, the duration of marriage, as well as information about the patient's illness...
September 2017: Psychiatria Danubina
https://www.readbyqxmd.com/read/28922738/mixed-symptoms-in-major-depressive-and-bipolar-disorders-a-systematic-review
#19
REVIEW
Gustavo H Vázquez, María Lolich, Casimiro Cabrera, Ruzica Jokic, Dusan Kolar, Leonardo Tondo, Ross J Baldessarini
BACKGROUND: The DSM-5 mixed features specifier for mood disorders encourages renewed interest in mixed states and led us to pool research findings regarding prevalence of mixed features in episodes of major depressive (MDD) and bipolar disorders (BD). METHODS: We systematically searched to July 2017 for reports on mixed symptoms in depressive episodes of MDD and in depression and mania or hypomania in types I and II BD. For primary mood-states and diagnostic groups we compared rates of the presence of mixed symptoms: as defined by DSM-5 (≥3 features opposite to the dominant mood-polarity but not overlapping those of the primary disorder) or as having any ≥3 features of opposite polarity...
January 1, 2018: Journal of Affective Disorders
https://www.readbyqxmd.com/read/28904603/mindfulness-based-treatment-for-bipolar-disorder-a-systematic-review-of-the-literature
#20
REVIEW
Sanja Bojic, Rodrigo Becerra
Despite the increasing number of studies examining the effects of mindfulness interventions on symptoms associated with Bipolar Disorder (BD), the effectiveness of this type of interventions remains unclear. The aim of the present systematic review was to (i) critically review all available evidence on Mindfulness Based Cognitive Therapy (MBCT) as a form of intervention for BD; (ii) discuss clinical implications of MBCT in treating patients with BD; and (iii) provide a direction for future research. The review presents findings from 13 studies (N = 429) that fulfilled the following selection criteria: (i) included BD patients; (ii) presented results separately for BD patients and control groups (where a control group was available); (iii) implemented MBCT intervention; (iv) were published in English; (v) were published in a peer reviewed journal; and (vi) reported results for adult participants...
August 2017: Europe's Journal of Psychology
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