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https://www.readbyqxmd.com/read/29758944/the-conundrum-of-gsk3-inhibitors-is-it-the-dawn-of-a-new-beginning
#1
Ratan V Bhat, Ulf Andersson, Shalini Andersson, Laurent Knerr, Udo Bauer, Anna Sundgren Andersson
Spanning over three decades of extensive drug discovery research, the efforts to develop a potent and selective GSK3 inhibitor as a therapeutic for the treatment of type 2 diabetes, Alzheimer's disease (AD), bipolar disorders and cancer have been futile. Since its initial discovery in 1980 and subsequent decades of research, one cannot underscore the importance of the target and the promise of a game changing disease modifier. Several pharmaceutical companies, biotech companies, and academic institutions raged in a quest to unravel the biology and discover potent and selective GSK3 inhibitors, some of which went through clinical trials...
May 11, 2018: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/29737385/the-influence-of-social-support-on-psychological-distress-in-canadian-adults-with-bipolar-disorder
#2
Christie D Warren, Ken Fowler, David Speed, Anna Walsh
INTRODUCTION: Individuals with bipolar I disorder (BD-I) and bipolar II disorder (BD-II) are at higher risk for experiencing high levels of psychological distress and low levels of social support. OBJECTIVES: The primary objectives of this study were to examine perceived social support and psychological distress among Canadian adults with self-reported BD-I or BD-II as diagnosed by a health professional and explore the relationship between types of social support and psychological distress within this sample...
May 8, 2018: Social Psychiatry and Psychiatric Epidemiology
https://www.readbyqxmd.com/read/29737181/comparative-familial-aggregation-of-bipolar-disorder-in-patients-with-bipolar-i-and-bipolar-ii-disorders
#3
Gordon B Parker, Mia Romano, Rebecca K Graham, Tahlia Ricciardi
OBJECTIVE: We sought to quantify the prevalence and differential prevalence of a bipolar disorder among family members of patients with a bipolar I or II disorder. METHODS: The sample comprised 1165 bipolar and 1041 unipolar patients, with the former then sub-typed as having either a bipolar I or II condition. Family history data was obtained via an online self-report tool. RESULTS: Prevalence of a family member having a bipolar disorder (of either sub-type) was distinctive (36...
May 1, 2018: Australasian Psychiatry: Bulletin of Royal Australian and New Zealand College of Psychiatrists
https://www.readbyqxmd.com/read/29723656/white-matter-microstructure-alterations-correlate-with-terminally-differentiated-cd8-effector-t-cell-depletion-in-the-peripheral-blood-in-mania-combined-dti-and-immunological-investigation-in-the-different-phases-of-bipolar-disorder
#4
Paola Magioncalda, Matteo Martino, Samuele Tardito, Bruno Sterlini, Benedetta Conio, Valentina Marozzi, Giulia Adavastro, Laura Capobianco, Daniel Russo, Alessia Parodi, Francesca Kalli, Giorgia Nasi, Tiziana Altosole, Niccolò Piaggio, Georg Northoff, Daniela Fenoglio, Matilde Inglese, Gilberto Filaci, Mario Amore
BACKGROUND: White matter (WM) microstructural abnormalities and, independently, signs of immunological activation were consistently demonstrated in bipolar disorder (BD). However, the relationship between WM and immunological alterations as well as their occurrence in the various phases of BD remain unclear. METHOD: In 60 type I BD patients - 20 in manic, 20 in depressive, 20 in euthymic phases - and 20 controls we investigated: (i) diffusion tensor imaging (DTI)-derived fractional anisotropy (FA), radial diffusivity (RD) and axial diffusivity (AD) using a tract-based spatial statistics (TBSS) approach; (ii) circulating T cell subpopulations frequencies, as well as plasma levels of different cytokines; (iii) potential relationships between WM and immunological data...
April 30, 2018: Brain, Behavior, and Immunity
https://www.readbyqxmd.com/read/29710812/electrocardiographic-and-electrooculographic-responses-to-external-emotions-and-their-transitions-in-bipolar-i-and-ii-disorders
#5
Guorong Ma, Chu Wang, Yanli Jia, Jiawei Wang, Bingren Zhang, Chanchan Shen, Hongying Fan, Bing Pan, Wei Wang
Bipolar disorder has two main types, bipolar I (BD I) and II (BD II), which present different affective states and personality characteristics, they might present different modes of emotional regulation. We hypothesized that the electrocardiogram and electrooculogram to external emotions are different in BD I and BD II. We asked 69 BD I and 54 BD II patients, and 139 healthy volunteers to undergo these tests in response to disgust, erotica, fear, happiness, neutral, and sadness, and their transitions. Their affective states were also measured...
April 28, 2018: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/29710135/association-between-muscular-strength-and-cognition-in-people-with-major-depression-or-bipolar-disorder-and-healthy-controls
#6
Joseph Firth, Josh A Firth, Brendon Stubbs, Davy Vancampfort, Felipe B Schuch, Mats Hallgren, Nicola Veronese, Alison R Yung, Jerome Sarris
Importance: Objective physical fitness measures, such as handgrip strength, are associated with physical, mental, and cognitive outcomes in the general population. Although people with mental illness experience reduced physical fitness and cognitive impairment, the association between muscular strength and cognition has not been examined to date. Objective: To determine associations between maximal handgrip strength and cognitive performance in people with major depression or bipolar disorder and in healthy controls...
April 18, 2018: JAMA Psychiatry
https://www.readbyqxmd.com/read/29707086/epigenetics-of-metabolic-syndrome-as-a-mood-disorder
#7
REVIEW
Sermin Kesebir
Mood disorders comprise major depressive disorder (MDD), bipolar disorder (BD) and the milder forms of these two disorders. Reccurring MDD is also known as unipolar disorder. The distinction between unipolar and bipolar disorders was first suggested in 1957 by Leonard and was made official after support by several studies in 1980. Indeed, in 150 AD, Aretaeus of Cappadocia wrote "It seems to me that melancholia is the beginning and a part of mania". Additionally, Kraepelin, who proposed the first medical disease model in psychiatry a century ago, considered recurrent unipolar depression cases under the category of bipolar disorder and conceptualized spectrum disorders...
June 2018: Journal of Clinical Medicine Research
https://www.readbyqxmd.com/read/29681025/major-differences-in-neurooxidative-and-neuronitrosative-stress-pathways-between-major-depressive-disorder-and-types-i-and-ii-bipolar-disorder
#8
Michael Maes, Kamila Landucci Bonifacio, Nayara Rampazzo Morelli, Heber Odebrecht Vargas, Décio Sabbatini Barbosa, André F Carvalho, Sandra Odebrecht Vargas Nunes
Accumulating evidence indicates that oxidative and nitrosative stress (O&NS) pathways play a key role in the pathophysiology of bipolar disorder (BD) and major depressive disorder (MDD). However, only a handful of studies have directly compared alterations in O&NS pathways among patients with MDD and BD types I (BPI) and BPII. Thus, the current study compared superoxide dismutase (SOD1), lipid hydroperoxides (LOOH), catalase, nitric oxide metabolites (NOx), malondialdehyde (MDA), and advanced oxidation protein products (AOPP) between mood disorder patients in a clinically remitted state...
April 21, 2018: Molecular Neurobiology
https://www.readbyqxmd.com/read/29659185/the-cochlear-spiral-ganglion-neurons-the-auditory-portion-of-the-viii-nerve
#9
Francisco Carricondo, Bárbara Romero-Gómez
The VIII nerve is formed by sensory neurons that innervate the inner ear, i.e. the vestibular and the auditory receptors. Neurons of the auditory portion, the cochlear afferent fibers that innervate the sensory hair cells of the organ of Corti, have their somas in the cochlear spiral ganglion where two types of neurons can be distinguished. Afferent type-I neurons are the 95% of the total population. Bipolar and myelinated fibers, each one innervates only one cochlear inner hair cell (IHC). In contrast, afferent type-II neurons are only the 5% of the spiral ganglion population...
April 16, 2018: Anatomical Record: Advances in Integrative Anatomy and Evolutionary Biology
https://www.readbyqxmd.com/read/29620693/longer-term-effectiveness-and-tolerability-of-adjunctive-open-lurasidone-in-patients-with-bipolar-disorder
#10
Shefali Miller, Dennis Do, Anda Gershon, Po W Wang, Farnaz Hooshmand, Lauren S Chang, Terence A Ketter
PURPOSE: To retrospectively assess lurasidone effectiveness/efficacy/tolerability in bipolar disorder (BD) patients. METHODS: Outpatients assessed with Systematic Treatment Enhancement Program for BD Affective Disorders Evaluation received naturalistically administered (primarily adjunctive) open lurasidone while monitored at visits with the Systematic Treatment Enhancement Program for BD Clinical Monitoring Form. RESULTS: Sixty-one patients (32 type I, 26 type II, 3 type not otherwise specified; mean ± SD age, 45...
June 2018: Journal of Clinical Psychopharmacology
https://www.readbyqxmd.com/read/29615672/morphometric-analysis-of-spread-platelets-identifies-integrin-%C3%AE-iib-%C3%AE-3-specific-contractile-phenotype
#11
Sebastian Lickert, Simona Sorrentino, Jan-Dirk Studt, Ohad Medalia, Viola Vogel, Ingmar Schoen
Haemostatic platelet function is intimately linked to cellular mechanics and cytoskeletal morphology. How cytoskeletal reorganizations give rise to a highly contractile phenotype that is necessary for clot contraction remains poorly understood. To elucidate this process in vitro, we developed a morphometric screen to quantify the spatial organization of actin fibres and vinculin adhesion sites in single spread platelets. Platelets from healthy donors predominantly adopted a bipolar morphology on fibrinogen and fibronectin, whereas distinguishable, more isotropic phenotypes on collagen type I or laminin...
April 3, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29610350/myosin-iia-interacts-with-the-spectrin-actin-membrane-skeleton-to-control-red-blood-cell-membrane-curvature-and-deformability
#12
Alyson S Smith, Roberta B Nowak, Sitong Zhou, Michael Giannetto, David S Gokhin, Julien Papoin, Ionita C Ghiran, Lionel Blanc, Jiandi Wan, Velia M Fowler
The biconcave disk shape and deformability of mammalian RBCs rely on the membrane skeleton, a viscoelastic network of short, membrane-associated actin filaments (F-actin) cross-linked by long, flexible spectrin tetramers. Nonmuscle myosin II (NMII) motors exert force on diverse F-actin networks to control cell shapes, but a function for NMII contractility in the 2D spectrin-F-actin network of RBCs has not been tested. Here, we show that RBCs contain membrane skeleton-associated NMIIA puncta, identified as bipolar filaments by superresolution fluorescence microscopy...
April 2, 2018: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29588611/the-utility-of-pharmacogenetic-testing-to-support-the-treatment-of-bipolar-disorder
#13
Marta Ielmini, Nicola Poloni, Ivano Caselli, Jordi Espadaler, Miquel Tuson, Alessandro Grecchi, Camilla Callegari
Background: Bipolar disorder (BD) is a frequent cause of disability, health care costs, and risk of suicide. Pharmacogenetic tests (PGTs) could help clinicians to identify those patients predisposed to the occurrence of adverse events (AEs) improving the understanding of the correlation between genetic variants and drug response. Materials and methods: The study evaluated 30 patients affected by BD type I or II (according to Diagnostic and Statistical Manual of Mental Disorders, version 5 ) who underwent the PGT Neurofarmagen® (AB-BIOTICS SA, Barcelona, Spain) between March 2016 and March 2017...
2018: Pharmacogenomics and Personalized Medicine
https://www.readbyqxmd.com/read/29548306/psychopathological-and-sociodemographic-features-in-treatment-resistant-unipolar-depression-versus-bipolar-depression-a-comparative-study
#14
Nicolas A Nuñez, Stefano Comai, Eduard Dumitrescu, Maykel F Ghabrash, John Tabaka, Marie Saint-Laurent, Stephen Vida, Theodore Kolivakis, Allan Fielding, Nancy Low, Pablo Cervantes, Linda Booij, Gabriella Gobbi
BACKGROUND: Some authors have hypothesized that Treatment-Resistant Unipolar Depression (TRD-UP) should be considered within the bipolar spectrum disorders and that hidden bipolarity may be a risk factor for TRD-UP. However, there are neither studies comparing clinical and sociodemographic data of patients with TRD-UP versus Bipolar (BP) disorders nor are there any examining differences versus Bipolar type I (BP-I) and Bipolar type II (BP-II). METHODS: Charts analysis was conducted on 194 patients followed at the Mood Disorders Clinic of the McGill University Health Center...
March 16, 2018: BMC Psychiatry
https://www.readbyqxmd.com/read/29542331/suprasensory-phenomena-in-those-with-a-bipolar-disorder
#15
Gordon Parker, Amelia Paterson, Mia Romano, Isabelle Granville Smith
OBJECTIVES: To increase awareness of the sensory changes experienced during hypo/manic and depressive states by those with a bipolar disorder and determine if the prevalence of such features is similar across differing bipolar sub-types. METHODS: We interviewed 66 patients who acknowledged sensory changes during hypo/manic states. They were allocated to bipolar I, bipolar II and soft bipolar diagnostic categories and the prevalence of 10 differing sensory changes was quantified during hypo/manic and depressive phases...
March 1, 2018: Australasian Psychiatry: Bulletin of Royal Australian and New Zealand College of Psychiatrists
https://www.readbyqxmd.com/read/29525354/clinical-and-psychopathological-features-associated-with-treatment-emergent-mania-in-bipolar-ii-depressed-outpatients-exposed-to-antidepressants
#16
Michele Fornaro, Annalisa Anastasia, Francesco Monaco, Stefano Novello, Andrea Fusco, Felice Iasevoli, Domenico De Berardis, Nicola Veronese, Marco Solmi, Andrea de Bartolomeis
BACKGROUND: Treatment-emergent affective switch (TEAS), including treatment-emergent mania (TEM), carry significant burden in the clinical management of bipolar depression, whereas the use of antidepressants raises both efficacy, safety and tolerability concerns. The present study assesses the prevalence and clinical correlates of TEM in selected sample of Bipolar Disorder (BD) Type-II (BD-II) acute depression outpatients. METHODS: Post-hoc analysis of the clinical and psychopathological features associated with TEM among 91 BD-II depressed outpatients exposed to antidepressants...
July 2018: Journal of Affective Disorders
https://www.readbyqxmd.com/read/29496589/association-of-translocator-protein-total-distribution-volume-with-duration-of-untreated-major-depressive-disorder-a-cross-sectional-study
#17
Elaine Setiawan, Sophia Attwells, Alan A Wilson, Romina Mizrahi, Pablo M Rusjan, Laura Miler, Cynthia Xu, Sarita Sharma, Stephen Kish, Sylvain Houle, Jeffrey H Meyer
BACKGROUND: People with major depressive disorder frequently exhibit increasing persistence of major depressive episodes. However, evidence for neuroprogression (ie, increasing brain pathology with longer duration of illness) is scarce. Microglial activation, which is an important component of neuroinflammation, is implicated in neuroprogression. We examined the relationship of translocator protein (TSPO) total distribution volume (VT ), a marker of microglial activation, with duration of untreated major depressive disorder, and with total illness duration and antidepressant exposure...
April 2018: Lancet Psychiatry
https://www.readbyqxmd.com/read/29441653/cognitive-control-under-stressful-conditions-in-transitional-age-youth-with-bipolar-disorder-diagnostic-and-sleep-related-differences-in-fronto-limbic-activation-patterns
#18
Adriane M Soehner, Tina R Goldstein, Sarah M Gratzmiller, Mary L Phillips, Peter L Franzen
OBJECTIVES: Adults with bipolar disorder (BD) display aberrant activation in fronto-limbic neural circuitry during cognitive control. However, fronto-limbic response to cognitive control, and factors destabilizing this circuitry, remain under-studied during the transition from adolescence to young adulthood in BD. Sleep patterns are disturbed in BD, undergo change in adolescence, and support brain function. Among transitional age youth, BD diagnosis and sleep (duration and variability) were tested as predictors of fronto-limbic response to a stressful cognitive control task...
February 13, 2018: Bipolar Disorders
https://www.readbyqxmd.com/read/29425665/newly-diagnosed-bipolar-disorder-and-the-subsequent-risk-of-erectile-dysfunction-a-nationwide-cohort-study
#19
Po-Hsun Hou, Frank Chiahung Mao, Geng-Ruei Chang, Min-Wei Huang, Yao-Ting Wang, Shiau-Shian Huang
BACKGROUND: Although erectile dysfunction (ED) is a common problem in men with mental disorders, there are few reports in the literature on the relation between bipolar disorder (BD) and ED. AIMS: To establish the incidence rate of ED in men with BD and assess the risk of ED in patients with BD according to type of treatment offered or no active treatment with medication during the 1st year of onset. METHODS: We identified 5,150 men with newly diagnosed BD using Taiwan's National Health Insurance Research Database...
February 2018: Journal of Sexual Medicine
https://www.readbyqxmd.com/read/29424148/-clinical-analysis-of-lpfp-pfna-and-bph-in-treating-femoral-intertrochanteric-fractures-in-elderly-patients
#20
Li-Jun Zhu, Xiao-Fei Li, Chao Liu, Cheng-Yu Lyu
OBJECTIVE: To evaluate the clinical results of locking proximal femur plate(LPFP), proximal femoral nail antirotation(PFNA) and bipolar hemiarthroplasty(BPH) in the treatment of femoral intertrochanteric fractures in elderly patients. METHODS: Retrospective analysis of the 86 elderly patients with femoral intertrochanteric fractures during June 2011 and August 2016 were enrolled in this study. The patients were divided into 3 groups: 26 cases in LPFP group included 10 males and 16 females with an average age of (72...
July 25, 2017: Zhongguo Gu Shang, China Journal of Orthopaedics and Traumatology
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