Joanna Pawlak, Aleksandra Szczepankiewicz, Maria Skibińska, Beata Narożna, Paweł Kapelski, Przemysław Zakowicz, Karolina Gattner, Dominik Spałek, Łukasz Mech, Monika Dmitrzak-Węglarz
PURPOSE: Bipolar affective disorder (BP) causes major functional impairment and reduced quality of life not only for patients, but also for many close relatives. We aimed to investigate mRNA levels in BP patients to find differentially expressed genes linked to specific clinical course variants; assuming that several gene expression alterations might indicate vulnerability pathways for specific course and severity of the disease. MATERIALS: We searched for up- and down-regulated genes comparing patients with diagnosis of BP type I (BPI) vs type II (BPII), history of suicide attempts, psychotic symptoms, predominance of manic/hypomanic episodes, and history of numerous episodes and comorbidity of substance use disorders or anxiety disorders...
February 17, 2024: Advances in Medical Sciences