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https://www.readbyqxmd.com/read/29786842/correlated-time-variation-of-bulk-microstructure-and-rheology-in-asphalt-binders
#1
A Ramm, N Sakib, A Bhasin, M C Downer
We use near-infrared dark-field optical microscopy to probe isothermal time variation of the volume fraction of naturally-occurring, subsurface microstructures in PG 64-22 asphalt binders at temperature T=30∘C, following a rapid heating (cooling) increment |ΔT|=20∘C from initial temperature T0=10∘C(50∘C). We compare these microstructure variations with isothermal time variations of the magnitude |G30∗(t)| of the bulk complex shear modulus measured for identical sample conditions with a Dynamic Shear Rheometer...
May 22, 2018: Journal of Microscopy
https://www.readbyqxmd.com/read/29786656/temperature-effects-on-force-and-actin%C3%A2-myosin-interaction-in-muscle-a-look-back-on-some-experimental-findings
#2
REVIEW
K W Ranatunga
Observations made in temperature studies on mammalian muscle during force development, shortening, and lengthening, are re-examined. The isometric force in active muscle goes up substantially on warming from less than 10 °C to temperatures closer to physiological (>30 °C), and the sigmoidal temperature dependence of this force has a half-maximum at ~10 °C. During steady shortening, when force is decreased to a steady level, the sigmoidal curve is more pronounced and shifted to higher temperatures, whereas, in lengthening muscle, the curve is shifted to lower temperatures, and there is a less marked increase with temperature...
May 22, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29785339/identification-of-potential-crucial-genes-and-pathways-associated-with-vein-graft-restenosis-based-on-gene-expression-analysis-in-experimental-rabbits
#3
Qiang Liu, Xiujie Yin, Mingzhu Li, Li Wan, Liqiao Liu, Xiang Zhong, Zhuoqi Liu, Qun Wang
Occlusive artery disease (CAD) is the leading cause of death worldwide. Bypass graft surgery remains the most prevalently performed treatment for occlusive arterial disease, and veins are the most frequently used conduits for surgical revascularization. However, the clinical efficacy of bypass graft surgery is highly affected by the long-term potency rates of vein grafts, and no optimal treatments are available for the prevention of vein graft restenosis (VGR) at present. Hence, there is an urgent need to improve our understanding of the molecular mechanisms involved in mediating VGR...
2018: PeerJ
https://www.readbyqxmd.com/read/29785201/speed-breeding-for-multiple-quantitative-traits-in-durum-wheat
#4
Samir Alahmad, Eric Dinglasan, Kung Ming Leung, Adnan Riaz, Nora Derbal, Kai P Voss-Fels, Jason A Able, Filippo M Bassi, Jack Christopher, Lee T Hickey
Background: Plant breeding requires numerous generations to be cycled and evaluated before an improved cultivar is released. This lengthy process is required to introduce and test multiple traits of interest. However, a technology for rapid generation advance named 'speed breeding' was successfully deployed in bread wheat ( Triticum aestivum L.) to achieve six generations per year while imposing phenotypic selection for foliar disease resistance and grain dormancy. Here, for the first time the deployment of this methodology is presented in durum wheat ( Triticum durum Desf...
2018: Plant Methods
https://www.readbyqxmd.com/read/29784623/regional-myocardial-strain-measurements-from-4dct-in-patients-with-normal-lv-function
#5
Elliot R McVeigh, Amir Pourmorteza, Michael Guttman, Veit Sandfort, Francisco Contijoch, Suhas Budhiraja, Zhennong Chen, David A Bluemke, Marcus Y Chen
BACKGROUND: CT SQUEEZ is a new automated technique to evaluate regional endocardial strain by tracking features on the endocardium from 4D cine CT data. The objective of this study was to measure the range of endocardial regional strain (RSCT ) values obtained with CT SQUEEZ in the normal human left ventricle (LV) from standard clinical 4D coronary CTA exams. METHODS: RSCT was measured over the heart cycle in 25 humans with normal LV function using cine CT from three vendors...
May 9, 2018: Journal of Cardiovascular Computed Tomography
https://www.readbyqxmd.com/read/29783155/construction-of-hierarchically-porous-monoliths-from-covalent-organic-frameworks-cofs-and-their-application-for-bisphenol-a-removal
#6
Zhongshan Liu, Hongwei Wang, Junjie Ou, Lianfang Chen, Mingliang Ye
Subject to synthetic conditions, covalent organic frameworks (COFs) are usually in powder form. Herein, taking an azine-linked COF as an example, detailed characterizations indicated that accessible aldehyde groups and hydrazine groups (CNNH2 , 88 μmol g-1 ) concurrently existed on its surface. Intrigued by such feature, we have developed an approach based on ring-opening polymerization to shape COF powder into monoliths. The crystallinity and micropore of COF in monoliths were well remained, meanwhile, the ring-opening polymerization remarkably generated macropores ranging from 0...
May 11, 2018: Journal of Hazardous Materials
https://www.readbyqxmd.com/read/29782624/the-underlying-mechanisms-involved-in-the-protective-effects-of-ischemic-postconditioning
#7
Rong Xie, Jinquan Li, Heng Zhao
Cerebral ischemic postconditioning (PostC) refers to a series of brief ischemia and reperfusion (I/R) cycles applied at the onset of reperfusion following an ischemic event. PostC has been shown to have neuroprotective effects, and represents a promising clinical strategy against cerebral ischemia-reperfusion injury. Many studies have indicated that cerebral PostC can effectively reduce neural cell death, cerebral edema and infarct size, improve cerebral circulation, and relieve inflammation, apoptosis and oxidative stress...
2018: Conditioning medicine
https://www.readbyqxmd.com/read/29781886/axis-ii-personality-disorders-are-linked-to-an-adverse-course-of-bipolar-disorder
#8
Robert M Post, Susan McElroy, Ralph Kupka, Trisha Suppes, Gerhard Hellemann, Willem Nolen, Mark Frye, Paul Keck, Heinz Grunze, Michael Rowe
The relationship of personality disorder (PD) psychopathology to the course of bipolar disorder remains inadequately described. After giving informed consent, more than 782 outpatients with bipolar disorder rated themselves on the 99-item Personality Disorder Questionnaire, Version 4 (PDQ4) when depressed or euthymic. They also rated six poor prognosis factors (PPFs). The relationships of the PPFs to the total PDQ4 score were examined by a linear regression. Even after correcting for the higher PDQ4 scores observed when patients were suffering depression, the PDQ4 was significantly related to a history of child abuse, early age of onset, an anxiety disorder comorbidity, rapid cycling, and 20 or more previous episodes, but not substance abuse...
May 17, 2018: Journal of Nervous and Mental Disease
https://www.readbyqxmd.com/read/29780880/circadian-and-brain-state-modulation-of-network-hyperexcitability-in-alzheimer-s-disease
#9
Rosalind Brown, Alice D Lam, Alfredo Gonzalez-Sulser, Andrew Ying, Mary Jones, Robert Chang-Chih Chou, Makis Tzioras, Crispin Y Jordan, Izabela Jedrasiak-Cape, Anne-Laure Hemonnot, Maurice Abou Jaoude, Andrew J Cole, Sydney S Cash, Takashi Saito, Takaomi Saido, Richard R Ribchester, Kevan Hashemi, Iris Oren
Network hyperexcitability is a feature of Alzheimer' disease (AD) as well as numerous transgenic mouse models of AD. While hyperexcitability in AD patients and AD animal models share certain features, the mechanistic overlap remains to be established. We aimed to identify features of network hyperexcitability in AD models that can be related to epileptiform activity signatures in AD patients. We studied network hyperexcitability in mice expressing amyloid precursor protein (APP) with mutations that cause familial AD, and compared a transgenic model that overexpresses human APP (hAPP) (J20), to a knock-in model expressing APP at physiological levels (APPNL/F )...
March 2018: ENeuro
https://www.readbyqxmd.com/read/29780666/chitin-distribution-in-the-oithona-digestive-and-reproductive-systems-revealed-by-fluorescence-microscopy
#10
Kevin Sugier, Benoit Vacherie, Astrid Cornils, Patrick Wincker, Jean-Louis Jamet, Mohammed-Amin Madoui
Among copepods, which are the most abundant animals on Earth, the genus Oithona is described as one of the most numerous and plays a major role in the marine food chain and biogeochemical cycles, particularly through the excretion of chitin-coated fecal pellets. Despite the morphology of several Oithona species is well known, knowledge of its internal anatomy and chitin distribution is still limited. To answer this problem, Oithona nana and O. similis individuals were stained by Wheat Germ Agglutinin-Fluorescein IsoThioCyanate (WGA-FITC) and DiAmidino-2-PhenylIndole (DAPI) for fluorescence microscopy observations...
2018: PeerJ
https://www.readbyqxmd.com/read/29780063/the-effect-of-ozone-on-colonic-epithelial-cells
#11
Hidetomo Himuro
Due to its strong oxidation activity, ozone has been well known to kill bacteria and exert toxic effects on human tissues. At the same time, ozone is being used for the treatment of diseases such as inflammatory bowel disease in some European countries. However, the use of ozone for therapeutic purposes, despite its strong toxic effects, remains largely unexplored. Interestingly, we found that intrarectal administration of ozone gas induced transient colonic epithelial cell damage characterized by the impairment of cell survival pathways involved in DNA replication, cell cycle, and mismatch repair...
May 21, 2018: Kurume Medical Journal
https://www.readbyqxmd.com/read/29779871/non-canonical-phototransduction-mediates-synchronization-of-the-drosophila-melanogaster-circadian-clock-and-retinal-light-responses
#12
Maite Ogueta, Roger C Hardie, Ralf Stanewsky
The daily light-dark cycles represent a key signal for synchronizing circadian clocks. Both insects and mammals possess dedicated "circadian" photoreceptors but also utilize the visual system for clock resetting. In Drosophila, circadian clock resetting is achieved by the blue-light photoreceptor cryptochrome (CRY), which is expressed within subsets of the brain clock neurons. In addition, rhodopsin-expressing photoreceptor cells contribute to light synchronization. Light resets the molecular clock by CRY-dependent degradation of the clock protein Timeless (TIM), although in specific subsets of key circadian pacemaker neurons, including the small ventral lateral neurons (s-LNvs), TIM and Period (PER) oscillations can be synchronized by light independent of CRY and canonical visual Rhodopsin phototransduction...
April 30, 2018: Current Biology: CB
https://www.readbyqxmd.com/read/29779113/preparation-and-properties-of-nanoparticles-trna-bivalent-metal-cation-me-2-complexes-and-prospects-of-their-practical-use
#13
V N Danilevich, V V Sorokin, Ya P Moiseev, S V Sizova
The patterns of formation of RNA nanoparticles (NPs) during thermal cycling of bacterial total tRNA in the presence of cations Ca2+ , Mn2+ , Ni2+ , Zn2+ , Co2+ , and Cu2+ were studied. The optimal conditions for the production of NPs were found, and it was revealed that their size depends on the ratio of the concentrations of Me2+ and tRNA. The concentration of reagents for obtaining NPs of small size (from 5 to 100 nm) was selected. It was shown that tRNA-based nanoparticles can comprise short (20-50 nt) ribooligonucleotides, including aptamers and siRNAs...
March 2018: Doklady. Biochemistry and Biophysics
https://www.readbyqxmd.com/read/29778873/bioanalysis-of-ibrutinib-and-its-dihydrodiol-and-glutathione-cycle-metabolites-by-liquid-chromatography-tandem-mass-spectrometry
#14
J J M Rood, P J A Dormans, M J van Haren, J H M Schellens, J H Beijnen, R W Sparidans
Ibrutinib is a targeted covalent inhibitor frequently used for the treatment of various lymphomas. In addition to oxidative metabolism, it is metabolized through glutathione coupling. The quantitative insight into this kind of metabolism is scarce, and tools for quantitation are lacking. The non-oxidative metabolism could prove a more prominent role when oxidative metabolism is impaired. Also, in-vitro studies could over-estimate the effect of CYP450-inhibition. To gain quantitative insight into this relatively unknown biotransformation pathway of the drug we have developed a validated simple, fast and sensitive bio-analytical assay for ibrutinib, dihydrodiol-ibrutinib, and the glutathione, cysteinylglycine and cysteine conjugates of ibrutinib in human plasma...
May 11, 2018: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/29778366/introduction-management-of-the-luteal-phase-in-assisted-reproductive-technology
#15
Georg Griesinger, David Meldrum
The increasing utilization of a gonadotropin-releasing hormone agonist ovulation trigger and the widespread use of artificial cycles for the transfer of frozen-thawed or donated embryos has renewed interest in the luteal phase in assisted reproductive technology. The "luteal phase defect" phenomenon is now understood as a continuum: there is less impairment with milder stimulation than with more intense ovarian stimulation, and less impairment after controlled ovarian stimulation and human chorionic gonadotropin ovulation triggering than after gonadotropin-releasing hormone agonist ovulation triggering, the latter being associated with rapid luteolysis...
May 2018: Fertility and Sterility
https://www.readbyqxmd.com/read/29777196/single-measurement-detection-of-individual-cell-ionic-oscillations-using-an-n-type-semiconductor-electrolyte-interface
#16
Mariusz Pietruszka, Monika Olszewska, Lukasz Machura, Edward Rówiński
Pollen tubes are used as models in studies on the type of tip-growth in plants. They are an example of polarised and rapid growth because pollen tubes are able to quickly invade the flower pistil in order to accomplish fertilisation. How different ionic fluxes are perceived, processed or generated in the pollen tube is still not satisfactorily understood. In order to measure the H+ , K+ , Ca2+ and Cl- fluxes of a single pollen tube, we developed an Electrical Lab on a Photovoltaic-Chip (ELoPvC) on which the evolving cell was immersed in an electrolyte of a germination medium...
May 18, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29775882/rapid-highly-efficient-and-stable-catalytic-hydrodechlorination-of-chlorophenols-over-novel-pd-cnts-ni-foam-composite-catalyst-in-continuous-flow
#17
Jun Xiong, Ying Ma, Wei Yang, Linshan Zhong
A novel Pd/CNTs-Ni foam composite catalyst was developed for catalytic hydrodechlorination of chlorophenols by using CNTs-Ni foam as support. Characterizations including FESEM, TEM/HRTEM, HAADF-STEM and element mapping revel that the composite catalyst with 2 wt.% Pd loading possesses high porous micro-network structure and high dispersed active Pd nanoparticles (5.81 nm) on CNTs surface. The HDC of chlorophenols over Pd/CNTs-Ni foam composite catalyst has been studied in continuous-flow packed bed reactor...
May 15, 2018: Journal of Hazardous Materials
https://www.readbyqxmd.com/read/29775293/mitigating-interfacial-potential-drop-of-cathode-solid-electrolyte-via-ionic-conductor-layer-to-enhance-interface-dynamics-for-solid-batteries
#18
Jia-Yan Liang, Xian-Xiang Zeng, Xu-Dong Zhang, Peng-Fei Wang, Jing-Yuan Ma, Ya-Xia Yin, Xiong-Wei Wu, Yu-Guo Guo, Lijun Wan
The rapid capacity decay caused by the poor contact and large polari-zation at the interface between the cathode and solid electrolytes is still a big challenge to overcome for high-power-density solid batteries. In this study, a superior Li+ conductive transition layer Li1.4Al0.4Ti1.6(PO4)3 is introduced to coat LiNi0.6Co0.2Mn0.2O2, as a model cathode, to mitigate polarization and enhance dynamic characteristics. The critical attribute for such superior dynamics is investigated by the atomic force microscopy with boundary potential analysis, revealing that the formed interfacial transition layer provides a gradual potential slope and sustain-released polarization, and endows the battery with improved cycling stability (90% after 100 cycles) and excellent rate capability (116 mA h g-1 at 2C) at room temperature, which enlightens the comprehension of interface engineering in the future solid batteries systems...
May 18, 2018: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/29774921/a-flexible-pressure-sensor-based-on-rgo-polyaniline-wrapped-sponge-with-tunable-sensitivity-for-human-motion-detection
#19
Gang Ge, Yichen Cai, Qiuchun Dong, Yizhou Zhang, Jinjun Shao, Wei Huang, Xiaochen Dong
High-performance stretchable and wearable electronic skins (E-skins) with high sensitivity and a large sensing range are urgently required with the rapid development of the Internet of things and artificial intelligence. Herein, a reduced graphene oxide (rGO)/polyaniline wrapped sponge is prepared via rGO coating and the in situ synthesis of polyaniline nanowires (PANI NWs) on the backbones of sponge for the fabrication of pressure sensors. From the as-prepared flexible sensor, tunable sensitivity (0.042 to 0...
May 18, 2018: Nanoscale
https://www.readbyqxmd.com/read/29774899/smartphone-based-rapid-quantification-of-viable-bacteria-by-single-cell-microdroplet-turbidity-imaging
#20
Xiaonan Cui, Lihui Ren, Yufei Shan, Xixian Wang, Zhenlong Yang, Chunyu Li, Jian Xu, Bo Ma
Standard plate count (SPC) has been recognized as the golden standard for the quantification of viable bacteria. However, SPC usually takes one to several days to grow individual cells into a visible colony, which greatly hampers its application in rapid bacteria enumeration. Here we present a microdroplet turbidity imaging based digital standard plate count (dSPC) method to overcome this hurdle. Instead of cultivating on agar plates, bacteria are encapsulated in monodisperse microdroplets for single-cell cultivation...
May 18, 2018: Analyst
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