Shuhei Tsuji, Chiharu Otani, Takahiro Horie, Shin Watanabe, Osamu Baba, Naoya Sowa, Yuya Ide, Asami Kashiwa, Takeru Makiyama, Hirohiko Imai, Yasuhiro Nakashima, Tomohiro Yamasaki, Sijia Xu, Kazuki Matsushita, Keita Suzuki, Fuquan Zou, Eitaro Kume, Koji Hasegawa, Takeshi Kimura, Akira Kakizuka, Koh Ono
AIMS: As heart failure (HF) progresses, ATP levels in myocardial cells decrease, and myocardial contractility also decreases. Inotropic drugs improve myocardial contractility but increase ATP consumption, leading to poor prognosis. Kyoto University Substance 121 (KUS121) is known to selectively inhibit the ATPase activity of valosin-containing protein, maintain cellular ATP levels, and manifest cytoprotective effects in several pathological conditions. The aim of this study is to determine the therapeutic effect of KUS121 on HF models...
December 12, 2023: Biomedicine & Pharmacotherapy