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https://www.readbyqxmd.com/read/28530723/precision-control-of-flow-rate-in-microfluidic-channels-using-photoresponsive-soft-polymer-actuators
#1
Colm Delaney, Peter McCluskey, Simon Coleman, Jeffrey Whyte, Nigel Kent, Dermot Diamond
A novel approach that allows control of flow in microfluidic channels with unsurpassed performance using light is described. Valve structures have been created using photoresponsive hydrogels based on spiropyran-functionalised pNIPAAm hydrogels photopolymerised around pillar structures within the channels. Valve actuation is controlled from outside the fluidic system using externally located LEDs. Highly precise and accurate flow rates can be selected by passing real-time flow rate measurements into a PID algorithm...
May 22, 2017: Lab on a Chip
https://www.readbyqxmd.com/read/28528394/a-novel-dual-wavelength-laser-stimulator-to-elicit-transient-and-tonic-nociceptive-stimulation
#2
Xiaoxi Dong, Tianjun Liu, Han Wang, Jichun Yang, Zhuying Chen, Yong Hu, Yingxin Li
This study aimed to develop a new laser stimulator to elicit both transient and sustained heat stimulation with a dual-wavelength laser system as a tool for the investigation of both transient and tonic experimental models of pain. The laser stimulator used a 980-nm pulsed laser to generate transient heat stimulation and a 1940-nm continuous-wave (CW) laser to provide sustained heat stimulation. The laser with 980-nm wavelength can elicit transient pain with less thermal injury, while the 1940-nm CW laser can effectively stimulate both superficial and deep nociceptors to elicit tonic pain...
May 20, 2017: Lasers in Medical Science
https://www.readbyqxmd.com/read/28525480/a-new-entrance-technique-for-c2-pedicle-screw-placement-and-the-use-in-patients-with-atlantoaxial-instability
#3
Jia-Ming Liu, Jian Jiang, Zhi-Li Liu, Xin-Hua Long, Wen-Zhao Chen, Yang Zhou, Song Gao, Lai-Chang He, Shan-Hu Huang
STUDY DESIGN: A prospective study and a technique note. OBJECTIVES: To introduce a new entrance technique for C2 pedicle screw placement and to measure the related linear and angular parameters about the entrance point on computed tomography (CT) images. The safety of this technique for patients with atlantoaxial instability was also evaluated. BACKGROUND DATA: Although earlier studies have introduced different methods for C2 pedicle screw placement, the entry points and the angular parameters may be variable...
June 2017: Clinical Spine Surgery
https://www.readbyqxmd.com/read/28523402/advances-in-the-care-of-primary-immunodeficiencies-pids-from-birth-to-adulthood
#4
Nizar Mahlaoui, Klaus Warnatz, Alison Jones, Sarita Workman, Andrew Cant
Primary immunodeficiencies (PIDs) are a widely heterogeneous group of inherited defects of the immune system consisting of many clinical phenotypes with at least 300 underlying genetic deficits currently known. Patients with PIDs can present with, or develop during the course of their life, a susceptibility to recurrent and chronic infection along with autoimmune, allergic, inflammatory, and/or proliferative disorders, all potentially leading to end-organ damage. In recent years, a combination of basic and clinical research has greatly improved understanding of the underlying immunological and genetic defects in PIDs, leading to improved diagnosis, classification, and treatment approaches...
May 18, 2017: Journal of Clinical Immunology
https://www.readbyqxmd.com/read/28513998/ibd-due-to-pid-inflammatory-bowel-disease-caused-by-primary-immunodeficiencies-clinical-presentations-review-of-literature-and-proposal-of-a-rational-diagnostic-algorithm
#5
REVIEW
Daniel Tegtmeyer, Maximilian Seidl, Patrick Gerner, Ulrich Baumann, Christian Klemann
Inflammatory bowel diseases (IBD) including Crohn's disease (CD) and ulcerative colitis (UC) have a multifactorial pathogenesis with complex interactions between polygenetic predispositions and environmental factors. However, IBD can also be caused by monogenic diseases, such as primary immunodeficiencies (PID). Recently, an increasing number of these altogether rare diseases has been described to present often primarily, or solely as IBD. Early recognition of these conditions enables adaption of therapies and thus directly benefits the course of IBDs...
May 17, 2017: Pediatric Allergy and Immunology
https://www.readbyqxmd.com/read/28511414/a-community-based-study-on-pelvic-inflammatory-disease-in-postmenopausal-females-microbiological-spectrum-and-socio-demographic-correlates
#6
Samreen Khan, M Athar Ansari, Shaista M Vasenwala, Zehra Mohsin
INTRODUCTION: Pelvic Inflammatory Disease (PID) is a common and serious complication of sexually transmitted diseases in young women but is rarely diagnosed in the postmenopausal women. Very few studies have been done regarding post-menopausal PID. AIM: To determine the burden of PID, associated micro-organisms, pathophysiology and risk factors among post-menopausal women of the community. MATERIALS AND METHODS: A cross-sectional study was conducted among 530 post-menopausal women in the registered field practice areas of the JN Medical College and Hospital, Aligarh, Uttar Pradesh, India...
March 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28504853/deriving-icd-11-personality-disorder-domains-from-dsm-5-traits-initial-attempt-to-harmonize-two-diagnostic-systems
#7
B Bach, M Sellbom, M Kongerslev, E Simonsen, R F Krueger, R Mulder
OBJECTIVE: The personality disorder domains proposed for the ICD-11 comprise Negative Affectivity, Detachment, Dissociality, Disinhibition, and Anankastia, which are reasonably concordant with the higher-order trait domains in the Alternative DSM-5 Model for Personality Disorders. METHOD: We examined (i) whether designated DSM-5 trait facets can be used to describe the proposed ICD-11 trait domains, and (ii) how these ICD-11 trait features are hierarchically organized...
May 15, 2017: Acta Psychiatrica Scandinavica
https://www.readbyqxmd.com/read/28503935/personality-inventory-for-dsm-5-pid-5-in-clinical-versus-nonclinical-individuals-generalizability-of-psychometric-features
#8
Bo Bach, Martin Sellbom, Erik Simonsen
The Personality Inventory for Diagnostic and Statistical Manual of Mental Disorders-Fifth Edition (PID-5) was developed for the assessment of pathological traits in clinical settings. However, most research on the PID-5 is derived from nonclinical samples. To date, the comparability and generalizability of PID-5 constructs across nonclinical and clinical samples have not been adequately investigated. Therefore, we investigated the measurement invariance, five-factor structure, and factor correlations across clinical and nonclinical samples...
May 1, 2017: Assessment
https://www.readbyqxmd.com/read/28499198/a-point-of-need-infrared-mediated-pcr-platform-with-compatible-lateral-flow-strip-for-hpv-detection
#9
Wenjia Liu, Mingfang Zhang, Xiaoyan Liu, Alok Sharma, Xianting Ding
With the increasing need of monitoring the epidemiology of serious infectious diseases, food hygiene, food additives and pesticide residues, it is urgent to develop portable, easy-to-use, inexpensive and rapid molecular diagnostic tools. Herein, we demonstrate a prototype of IR mediated Conducting Oil and CarbOn Nanotube circUlaTing PCR (IR-COCONUT PCR) platform for nucleic acid amplification. The presented platform offers a new solution for miniaturized PCR instruments with non-contact heaters by using conducting oil and carbon nanotube as a medium in IR mediated PCR...
April 29, 2017: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/28497675/evaluation-of-pulmonary-complications-in-patients-with-primary-immunodeficiency-disorders
#10
M Reisi, G Azizi, F Kiaee, F Masiha, R Shirzadi, T Momen, H Rafiemanesh, N Tavakolinia, M Modaresi, A Aghamohammadi
Background. Primary immunodeficiencies (PIDs) are inherited disorders in which one or several components of immune system are defected. Moreover, affected patients are at high risk for developing recurrent infections, particularly pulmonary infections. The spectrum of pulmonary manifestations in PIDs is broad, and includes acute and chronic infection, structural abnormalities (eg, bronchiectasis), malignancy and dysregulated inflammation resulting in tissue damage. In this study, our aims are to evaluate pulmonary complications in PID patients...
May 2017: European Annals of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28497326/evaluation-of-pelvic-inflammatory-disease-potential-in-cholinesterase-inhibitor-pesticide-exposed-females
#11
Eman I Draz, Azza M Hassan, Haidy S Khalil, Mohamed A Elomary
Cholinesterase inhibitor pesticides, mainly organophosphates and carbamates, are commonly used in Egypt. Chronic exposure of males and females working in agriculture is expected. The study aimed to relate exposure to cholinesterase inhibitor pesticides to the development of pelvic inflammatory disease (PID). This is a case-control study that was conducted among 84 females. Seventy patients complained of pelvic inflammatory disease visited the outpatient Gynecology and Obstetrics Clinic. Fourteen females were not suffering from PID and were chosen as a control group...
May 11, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28495004/optimized-pid-control-of-depth-of-hypnosis-in-anesthesia
#12
Fabrizio Padula, Clara Ionescu, Nicola Latronico, Massimiliano Paltenghi, Antonio Visioli, Giulio Vivacqua
BACKGROUND AND OBJECTIVE: This paper addresses the use of proportional-integral-derivative controllers for regulating the depth of hypnosis in anesthesia by using propofol administration and the bispectral index as a controlled variable. In fact, introducing an automatic control system might provide significant benefits for the patient in reducing the risk for under- and over-dosing. METHODS: In this study, the controller parameters are obtained through genetic algorithms by solving a min-max optimization problem...
June 2017: Computer Methods and Programs in Biomedicine
https://www.readbyqxmd.com/read/28486505/modeling-of-inter-neuronal-coupling-medium-and-its-impact-on-neuronal-synchronization
#13
Muhammad Iqbal, Muhammad Rehan, Keum-Shik Hong
In this paper, modeling of the coupling medium between two neurons, the effects of the model parameters on the synchronization of those neurons, and compensation of coupling strength deficiency in synchronization are studied. Our study exploits the inter-neuronal coupling medium and investigates its intrinsic properties in order to get insight into neuronal-information transmittance and, there from, brain-information processing. A novel electrical model of the coupling medium that represents a well-known RLC circuit attributable to the coupling medium's intrinsic resistive, inductive, and capacitive properties is derived...
2017: PloS One
https://www.readbyqxmd.com/read/28484900/diagnostic-delay-of-primary-immunodeficiencies-at-a-tertiary-care-hospital-in-peru-brief-report
#14
Liz E Veramendi-Espinoza, Jessica H Zafra-Tanaka, Gabriela A Pérez-Casquino, Wilmer O Córdova-Calderón
OBJECTIVE: The aim of the study was to assess the diagnostic delay in pediatric patients with primary immunodeficiencies (PID) at a tertiary care hospital in Peru. METHODS: A descriptive study was carried out in which patients from a third-level referral center in Peru were included. Those without a specific diagnosis of PID were excluded. Data was collected by reviewing the medical records and interviewing patients' family members. RESULTS: A total of 45 patients with a mean of 7...
May 2017: Journal of Clinical Immunology
https://www.readbyqxmd.com/read/28480310/genetic-engineering-and-manufacturing-of-hematopoietic-stem-cells
#15
REVIEW
Xiuyan Wang, Isabelle Rivière
The marketing approval of genetically engineered hematopoietic stem cells (HSCs) as the first-line therapy for the treatment of severe combined immunodeficiency due to adenosine deaminase deficiency (ADA-SCID) is a tribute to the substantial progress that has been made regarding HSC engineering in the past decade. Reproducible manufacturing of high-quality, clinical-grade, genetically engineered HSCs is the foundation for broadening the application of this technology. Herein, the current state-of-the-art manufacturing platforms to genetically engineer HSCs as well as the challenges pertaining to production standardization and product characterization are addressed in the context of primary immunodeficiency diseases (PIDs) and other monogenic disorders...
June 16, 2017: Molecular Therapy. Methods & Clinical Development
https://www.readbyqxmd.com/read/28476344/robust-absolute-stability-analysis-for-interval-nonlinear-active-disturbance-rejection-based-control-system
#16
Jie Li, Yuanqing Xia, Xiaohui Qi, Pengpeng Zhao
Active disturbance rejection control (ADRC) is a relatively new, quite different but very practical control technology, which shows much promise in replacement of proportion-integration-differentiation (PID) with unmistakable advantage in performance and practicality. This paper mainly concerns with the robust absolute stability of the ADRC based control system with parameter perturbations of the plant, i.e., ADRC based interval control system. Firstly, the system is transformed into a perturbed indirect Lurie system...
May 2, 2017: ISA Transactions
https://www.readbyqxmd.com/read/28472050/empirically-characteristic-analysis-of-chaotic-pid-controlling-particle-swarm-optimization
#17
Danping Yan, Yongzhong Lu, Min Zhou, Shiping Chen, David Levy
Since chaos systems generally have the intrinsic properties of sensitivity to initial conditions, topological mixing and density of periodic orbits, they may tactfully use the chaotic ergodic orbits to achieve the global optimum or their better approximation to given cost functions with high probability. During the past decade, they have increasingly received much attention from academic community and industry society throughout the world. To improve the performance of particle swarm optimization (PSO), we herein propose a chaotic proportional integral derivative (PID) controlling PSO algorithm by the hybridization of chaotic logistic dynamics and hierarchical inertia weight...
2017: PloS One
https://www.readbyqxmd.com/read/28468853/high-macrolide-resistance-in-mycoplasma-genitalium-strains-causing-infection-in-auckland-new-zealand
#18
Indira Basu, Sally A Roberts, James E Bower, Gillian Henderson, Murray Reid
Mycoplasma genitalium has been implicated as a cause of acute and chronic non-chlamydial non-gonococcal urethritis (NCNGU) and pelvic inflammatory disease (PID) (1).….
May 3, 2017: Journal of Clinical Microbiology
https://www.readbyqxmd.com/read/28468124/temporal-evolution-of-ultrafine-particles-and-of-alveolar-deposited-surface-area-from-main-indoor-combustion-and-non-combustion-sources-in-a-model-room
#19
Maurizio Manigrasso, Matteo Vitali, Carmela Protano, Pasquale Avino
Aerosol number size distributions, PM mass concentrations, alveolar deposited surface areas (ADSAs) and VOC concentrations were measured in a model room when aerosol was emitted by sources frequently encountered in indoor environments. Both combustion and non-combustion sources were considered. The most intense aerosol emission occurred when combustion sources were active (as high as 4.1×10(7)particlescm(-3) for two meat grilling sessions; the first with exhaust ventilation, the second without). An intense spike generation of nucleation particles occurred when appliances equipped with brush electric motors were operating (as high as 10(6)particlescm(-3) on switching on an electric drill)...
April 29, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28466095/survival-of-the-fetus-fetal-b-and-t-cell-receptor-repertoire-development
#20
REVIEW
Erez Rechavi, Raz Somech
A mature and diverse T and B cell receptor repertoire is a prerequisite for immunocompetence. In light of its increased susceptibility to infection, the human fetus has long been considered deficient in this regard. However, data accumulated since the 1990s and in earnest in the past couple of years paints a more complicated picture. As we describe in this review, mechanisms responsible for generating a diverse receptor repertoire, such as somatic recombination, class switch recombination, and somatic hypermutation, are all operational to surprising extents in the growing fetus...
May 2, 2017: Seminars in Immunopathology
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