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https://www.readbyqxmd.com/read/28815122/incorporating-data-citation-in-a-biomedical-repository-an-implementation-use-case
#1
Snehil Gupta, Connie Zabarovskaya, Brian Romine, Daniel A Vianello, Cynthia Hudson Vitale, Leslie D McIntosh
Research data is a dynamic and evolving entity and the ability to cite such data depends on recreating the same datasets utilized in the original research. Despite the availability of several existing technologies, most data repositories lack the necessary setup to recreate a point-in-time snapshot of data, let alone long-term sustainability of dynamic data without restoring an entire database. Through this project, we adopted a subset of the Research Data Alliance data citation working group recommendations to establish a robust informatics system supporting dynamic data and its use for reproducible research within our evolving clinical data repository...
2017: AMIA Summits on Translational Science Proceedings
https://www.readbyqxmd.com/read/28813896/nonlinear-disturbance-observer-based-sliding-mode-control-of-a-cable-driven-rehabilitation-robot
#2
Jie Niu, Qianqian Yang, Guangtao Chen, Rong Song
This paper introduces a cable-driven robot for upper-limb rehabilitation. Kinematic and dynamic of this rehabilitation robot is analyzed. A sliding mode controller combined with a nonlinear disturbance observer is proposed to control this robot in the presence of disturbances. Simulation is carried out to prove the effectiveness of the proposed control scheme, and the results of the proposed controller is compared with a PID controller and a traditional sliding mode controller. Results show that the proposed controller can effectively improve the tracking performance as compared with the other two controllers and cause lower chattering as compared with a traditional sliding mode controller...
July 2017: IEEE ... International Conference on Rehabilitation Robotics: [proceedings]
https://www.readbyqxmd.com/read/28813823/a-generalized-framework-to-achieve-coordinated-admittance-control-for-multi-joint-lower-limb-robotic-exoskeleton
#3
Kai Gui, Honghai Liu, Dingguo Zhang
Traditional joint space admittance controller for N-DOF robotic systems is complexity and easily leads to incongruous movement among all joints. Our study introduces a central pattern generator (CPG) network into one-dimension joint space admittance control for the custom-made lower limb robotic exoskeleton with four DOFs, to guarantee the coordinated movement and security of users. The predefined trajectories for four joints are produced by CPG. Unilateral knee joint torque of subjects is detected based on corresponding muscle EMG signals...
July 2017: IEEE ... International Conference on Rehabilitation Robotics: [proceedings]
https://www.readbyqxmd.com/read/28811575/biological-and-functional-characterization-of-bone-marrow-derived-mesenchymal-stromal-cells-from-patients-affected-by-primary-immunodeficiency
#4
Nadia Starc, Daniela Ingo, Antonella Conforti, Valeria Rossella, Luigi Tomao, Angela Pitisci, Fabiola De Mattia, Immacolata Brigida, Mattia Algeri, Mauro Montanari, Giuseppe Palumbo, Pietro Merli, Paolo Rossi, Alessandro Aiuti, Franco Locatelli, Maria Ester Bernardo
Mesenchymal stromal cells (MSCs) represent a key component of bone marrow (BM) microenvironment and display immune-regulatory properties. We performed a detailed analysis of biological/functional properties of BM-MSCs derived from 33 pediatric patients affected by primary immune-deficiencies (PID-MSCs): 7 Chronic Granulomatous Disease (CGD), 15 Wiskott-Aldrich Syndrome (WAS), 11 Severe Combined Immunodeficiency (SCID). Results were compared with MSCs from 15 age-matched pediatric healthy-donors (HD-MSCs). Clonogenic and proliferative capacity, differentiation ability, immunophenotype, immunomodulatory properties were analyzed...
August 15, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28805689/visual-servoing-for-an-autonomous-hexarotor-using-a-neural-network-based-pid-controller
#5
Carlos Lopez-Franco, Javier Gomez-Avila, Alma Y Alanis, Nancy Arana-Daniel, Carlos Villaseñor
In recent years, unmanned aerial vehicles (UAVs) have gained significant attention. However, we face two major drawbacks when working with UAVs: high nonlinearities and unknown position in 3D space since it is not provided with on-board sensors that can measure its position with respect to a global coordinate system. In this paper, we present a real-time implementation of a servo control, integrating vision sensors, with a neural proportional integral derivative (PID), in order to develop an hexarotor image based visual servo control (IBVS) that knows the position of the robot by using a velocity vector as a reference to control the hexarotor position...
August 12, 2017: Sensors
https://www.readbyqxmd.com/read/28803625/modified-reduced-order-observer-based-linear-active-disturbance-rejection-control-for-tito-systems
#6
S N Pawar, R H Chile, B M Patre
This paper proposes an observer based control approach for two input and two output (TITO) plant affected by the lumped disturbance which includes the undesirable effect of cross couplings, parametric uncertainties, and external disturbances. A modified reduced order extended state observer (ESO) based active disturbance rejection control (ADRC) is designed to estimate the lumped disturbance actively as an extended state and compensate its effect by adding it to the control. The decoupled mechanism has been used to determine the controller parameters, while the proposed control technique is applied to the TITO coupled plant without using decoupler to show its efficacy...
August 10, 2017: ISA Transactions
https://www.readbyqxmd.com/read/28791687/skin-signs-of-primary-immunodeficiencies-how-to-find-the-genes-to-check
#7
REVIEW
M Ettinger, J Schreml, K Wirsching, M Berneburg, S Schreml
Primary immunodeficiencies (PIDs) are a heterogeneous group of rare diseases that result from defects in immune system development and/or function. The clinical manifestations of PIDs are highly variable, but most disorders involve at least an increased susceptibility to infection. Furthermore, cutaneous manifestations are very common in PIDs. As an easy accessible organ, skin canbecrucial for early diagnosis and treatment. This is relevant for preventing significant disease-associated morbidity and mortality...
August 9, 2017: British Journal of Dermatology
https://www.readbyqxmd.com/read/28791010/uses-of-next-generation-sequencing-technologies-for-the-diagnosis-of-primary-immunodeficiencies
#8
REVIEW
Michael Seleman, Rodrigo Hoyos-Bachiloglu, Raif S Geha, Janet Chou
Primary immunodeficiencies (PIDs) are genetic disorders impairing host immunity, leading to life-threatening infections, autoimmunity, and/or malignancies. Genomic technologies have been critical for expediting the discovery of novel genetic defects underlying PIDs, expanding our knowledge of the complex clinical phenotypes associated with PIDs, and in shifting paradigms of PID pathogenesis. Once considered Mendelian, monogenic, and completely penetrant disorders, genomic studies have redefined PIDs as a heterogeneous group of diseases found in the global population that may arise through multigenic defects, non-germline transmission, and with variable penetrance...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28790306/quantitative-diagnostic-imaging-of-cancer-tissues-by-using-phosphor-integrated-dots-with-ultra-high-brightness
#9
Kohsuke Gonda, Mika Watanabe, Hiroshi Tada, Minoru Miyashita, Yayoi Takahashi-Aoyama, Takashi Kamei, Takanori Ishida, Shin Usami, Hisashi Hirakawa, Yoichiro Kakugawa, Yohei Hamanaka, Ryuichi Yoshida, Akihiko Furuta, Hisatake Okada, Hideki Goda, Hiroshi Negishi, Kensaku Takanashi, Masaru Takahashi, Yuichi Ozaki, Yuka Yoshihara, Yasushi Nakano, Noriaki Ohuchi
The quantitative sensitivity and dynamic range of conventional immunohistochemistry (IHC) with 3,3'-diaminobenzidine (IHC-DAB) used in pathological diagnosis in hospitals are poor, because enzyme activity can affect the IHC-DAB chromogenic reaction. Although fluorescent IHC can effectively increase the quantitative sensitivity of conventional IHC, tissue autofluorescence interferes with the sensitivity. Here, we created new fluorescent nanoparticles called phosphor-integrated dots (PIDs). PIDs have 100-fold greater brightness and a more than 300-fold greater dynamic range than those of commercially available fluorescent nanoparticles, quantum dots, whose fluorescence intensity is comparable to tissue autofluorescence...
August 8, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28783693/primary-immunodeficiencies-suggest-redundancy-within-the-human-immune-system
#10
REVIEW
Alain Fischer, Antonio Rausell
Pathogen-driven evolution has shaped the complexity of the human immune system. Our genome contains at least 1854 gene products involved in immune responses. However, the redundancy and robustness of the immune system need further characterization. One way to examine this redundancy is through the study of monogenic primary immunodeficiencies (PIDs) associated with infections. Causal mutations affecting innate immunity genes are, in relative terms, close to seven times less frequent than those affecting adaptive immunity genes in PIDs...
December 23, 2016: Science Immunology
https://www.readbyqxmd.com/read/28780238/tcr%C3%AE-%C3%AE-and-cd19-cell-depleted-haploidentical-and-mismatched-hematopoietic-stem-cell-transplantation-in-primary-immune-deficiency
#11
Ravi M Shah, Reem Elfeky, Zohreh Nademi, Waseem Qasim, Persis Amrolia, Robert Chiesa, Kanchan Rao, Giovanna Lucchini, Juliana M F Silva, Austen Worth, Dawn Barge, David Ryan, Jane Conn, Andrew J Cant, Roderick Skinner, Intan Juliana Abd Hamid, Terence Flood, Mario Abinun, Sophie Hambleton, Andrew R Gennery, Paul Veys, Mary Slatter
BACKGROUND: Allogeneic hematopoietic stem cell transplantation (HSCT) is used as a therapeutic approach for primary immunodeficiencies (PIDs). The best outcomes have been achieved using HLA-matched donors, but when a matched donor is not available, a haploidentical or mismatched unrelated donor (mMUD) can be useful. Various strategies are used to mitigate the risk of graft versus host disease (GvHD) and rejection associated with such transplants. OBJECTIVE: We sought to evaluate the outcomes of haploidentical or mMUD HSCT after depleting GvHD causing TCRαβCD3+ cells from the graft...
August 2, 2017: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28762367/socioeconomic-status-of-parents-and-the-occurrence-of-pelvic-inflammatory-disease-among-undergraduates-attending-irrua-specialist-teaching-hospital-irrua-edo-state-nigeria
#12
Tijani Idris Ahmad Oseni, Michael Adeoye Odewale
BACKGROUND: Pelvic inflammatory disease (PID) is a major cause of gynaecological morbidity globally. Complications from PID include infertility, ectopic pregnancy and chronic pelvic pain. Low socioeconomic status (SES) is a risk factor for the occurrence of PID. OBJECTIVE: The aim of this study was to determine the association between SES of parents and the occurrence of PID among undergraduates attending Irrua Specialist Teaching Hospital, Irrua. METHODOLOGY: The study was a hospital-based, descriptive cross-sectional study...
April 2017: Nigerian Postgraduate Medical Journal
https://www.readbyqxmd.com/read/28762254/the-effects-of-prenatal-iron-deficiency-and-risperidone-treatment-on-the-rat-frontal-cortex-%C3%A2-a-proteomic-analysis
#13
Lorna Farrelly, Maria Victoria Rosato-Siri, Melanie Föcking, Martin Codagnone, Analia Reines, Patrick Dicker, Kieran Wynne, Michael Farrell, Mary Cannon, Gerard Cagney, Juana Maria Pasquini, David R Cotter
Prenatal iron deficiency (pID) has been described to increase the risk for neurodevelopmental disorders such as autism and schizophrenia; however, the precise molecular mechanisms are still unknown. Here, we utilized high throughput mass spectrometry to examine the proteomic effects of pID in adulthood on the rat frontal cortex area (FCA). In addition, the FCA proteome was examined in adulthood following risperidone treatment in adolescence to see if these effects could be prevented. We identified 1501 proteins of which 100 were significantly differentially expressed in the FCA at post-natal day 90...
July 31, 2017: Proteomics
https://www.readbyqxmd.com/read/28755067/efficacy-and-safety-of-human-intravenous-immunoglobulin-10-panzyga%C3%A2-in-patients-with-primary-immunodeficiency-diseases-a-two-stage-multicenter-prospective-open-label-study
#14
Michael Borte, Isaac R Melamed, Grazyna Pulka, Barbara Pyringer, Alan P Knutsen, Hans D Ochs, Roger H Kobayashi, Ai Lan Kobayashi, Sudhir Gupta, Magdalena Strach, William Smits, Anna Pituch-Noworolska, James N Moy
PURPOSE: To assess the efficacy and safety of panzyga® (intravenous immunoglobulin 10%) in preventing serious bacterial infections (SBIs) in patients with primary immunodeficiency diseases (PIDs), a prospective, open-label, multicenter, phase 3 study and an open-label extension study were undertaken. METHODS: Initially, the study drug (infusion rate ≤0.08 mL/kg/min) was administered at intervals of 3 or 4 weeks for 12 months, followed by 3 months of panzyga® at infusion rates increasing from 0...
July 29, 2017: Journal of Clinical Immunology
https://www.readbyqxmd.com/read/28752571/haematopoietic-stem-cell-transplantation-for-primary-immunodeficiency-syndromes-a-5-year-single-centre-experience
#15
Melissa Norman, Clementine David, Brynn Wainstein, John B Ziegler, Richard Cohn, Richard Mitchell, Tracey O'Brien, Susan Russell, Toby Trahair, Annette Trickett, Katie Frith, Paul Gray
AIM: Haematopoietic stem cell transplantation (HSCT) is a central therapy in the treatment of primary immunodeficiency diseases (PIDs). Over the past 5 years, outcomes have been greatly improved due to earlier diagnosis, improved donor availability, advancements in graft manipulation and the use of less toxic preparative regimens. We present a 5-year audit of HSCT for PID at a single Australian tertiary hospital. METHODS: Retrospective case note review identified diagnosis, pre-transplant medical morbidity, transplant protocol, engraftment, adverse events, post-transplant immune reconstitution and general health...
July 28, 2017: Journal of Paediatrics and Child Health
https://www.readbyqxmd.com/read/28748605/management-of-chemotherapy-induced-febrile-neutropenia-in-pediatric-oncology-patients-a-north-american-survey-of-pediatric-hematology-oncology-and-pediatric-infectious-disease-physicians
#16
Rochelle R Maxwell, Dana Egan-Sherry, Jonathan B Gill, Michael E Roth
BACKGROUND: Chemotherapy-induced febrile neutropenia (FN) is traditionally managed with hospital admission for parenteral antibiotics until neutropenia resolves. Recent studies have explored risk stratification and the safety of managing "low-risk" patients as outpatients. Few studies have directly assessed pediatric provider preferences for managing FN. PROCEDURE: We conducted a survey of practicing US and Canadian pediatric hematology/oncology (PHO) and pediatric infectious disease (PID) physicians to assess their FN management preferences using case scenarios with varying risk profiles...
July 27, 2017: Pediatric Blood & Cancer
https://www.readbyqxmd.com/read/28745349/photo-induced-proton-coupled-electron-transfer-and-dissociation-of-isolated-flavin-adenine-dinucleotide-mono-anions
#17
Mark H Stockett
The intrinsic optical absorption spectrum and photo-dissociation pathways of flavin adenine dinucleotide (FAD) mono-anions isolated in vacuo are probed using photo-induced dissociation (PID) action spectroscopy. The main photo-products are lumichrome and formylmethylflavin. Evidence is presented that the dissociation pathway leading to these products is non-statistical i.e. occurs during the excited state lifetime. This suggests that the stacking of the adenine and alloxazine chromophores, which enables ultra-fast quenching of the flavin excited state by photo-induced electron transfer in aqueous solution, is inhibited in vacuo...
July 26, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/28743717/analysis-of-the-recovery-of-cd247-expression-in-a-pid-patient-insights-into-the-spontaneous-repair-of-defective-genes
#18
Alfonso Blázquez-Moreno, Adriana Pérez-Portilla, Miriam Agúndez-Llaca, Daniela Dukovska, Mar Valés-Gómez, Cigdem Aydogmus, Aydan Ikinciogullari, José R Regueiro, Hugh T Reyburn
Mutations in T-cell antigen receptor (TCR) subunits genes cause rare immunodeficiency diseases characterized by impaired expression of the TCR at the cell surface and selective T lymphopenia. Here detailed analyses of spontaneously arising somatic mutations that recover CD247, and so TCR expression, in a newly identified CD247 deficient patient are described. The recovery of CD247 expression in some patient T cells was associated with both reversion of the inactivating mutation and a variant with a compensating mutation that could reconstitute TCR expression, but not as efficiently as wild-type CD247...
July 25, 2017: Blood
https://www.readbyqxmd.com/read/28740426/efficacy-of-flurbiprofen-8-75-mg-delivered-as-a-spray-or-lozenge-in-patients-with-sore-throat-due-to-upper-respiratory-tract-infection-a-randomized-non-inferiority-trial-in-the-russian-federation
#19
Eugenia Radkova, Natalia Burova, Valeria Bychkova, Robert DeVito
OBJECTIVE: To assess the efficacy of flurbiprofen 8.75 mg delivered as a spray or lozenge in patients with sore throat due to upper respiratory tract infection (URTI). MATERIALS AND METHODS: This multicenter, double-blind, double-dummy, non-inferiority study randomized 440 adults with recent-onset, moderate-to-severe sore throat due to URTI to a single dose of either flurbiprofen 8.75 mg spray (n=218) or flurbiprofen 8.75 mg lozenge (n=222). The presence or absence of beta-hemolytic streptococci (A or C) was confirmed by culture tests (throat swab)...
2017: Journal of Pain Research
https://www.readbyqxmd.com/read/28735808/autoimmunity-and-its-association-with-regulatory-t-cells-and-b-cell-subsets-in-patients-with-common-variable-immunodeficiency
#20
G Azizi, H Abolhassani, F Kiaee, N Tavakolinia, H Rafiemanesh, R Yazdani, S A Mahdaviani, S Mohammadikhajehdehi, M Tavakol, V Ziaee, B Negahdari, J Mohammadi, A Mirshafiey, A Aghamohammadi
BACKGROUND: Common variable immunodeficiency (CVID) is one of the most prevalent symptomatic primary immunodeficiencies (PIDs), which manifests a wide clinical variability such as autoimmunity, as well as T cell and B cell abnormalities. METHODS: A total of 72 patients with CVID were enrolled in this study. Patients were evaluated for clinical manifestations and classified according to the presence or absence of autoimmune disease. We measured regulatory T cells (Tregs) and B-cell subsets using flow cytometry, as well as specific antibody response (SAR) to pneumococcal vaccine, autoantibodies and anti-IgA in patients...
July 20, 2017: Allergologia et Immunopathologia
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