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https://www.readbyqxmd.com/read/28723190/in-search-of-the-ultimate-benzene-sensor-the-etqxbox-solution
#1
Jakub W Trzciński, Roberta Pinalli, Nicolò Riboni, Alessandro Pedrini, Federica Bianchi, Stefano Zampolli, Ivan Elmi, Chiara Massera, Franco Ugozzoli, Enrico Dalcanale
In this work we report a comprehensive study leading to the fabrication of a prototype sensor for environmental benzene monitoring. The required high selectivity and ppb-level sensitivity are obtained by coupling a silicon-integrated concentration unit containing the specifically designed EtQxBox cavitand to a miniaturized PID detector. In the resulting stand-alone sensor, the EtQxBox receptor acts at the same time as highly sensitive preconcentrator for BTEX and GC-like separation phase, allowing for the selective desorption of benzene over TEX...
April 28, 2017: ACS Sensors
https://www.readbyqxmd.com/read/28721392/the-response-to-typhi-vi-vaccination-is-compromised-in-individuals-with-primary-immunodeficiency
#2
Jeevani Kumarage, Suranjith L Seneviratne, Vijitha Senaratne, Amitha Fernando, Kirthi Gunasekera, Bandu Gunasena, Padmalal Gurugama, Sudath Peiris, Antony R Parker, Stephen Harding, Nilhan Rajiva de Silva
Measurement of an individuals ability to respond to polysaccharide antigens is a crucial test to determine adaptive immunity. Currently the response to Pneumovax(®) is utilized but with the success of Prevnar(®), measurement of the response to Pneumovax may be challenging. The aim of the study was to assess the response to Typhi Vi vaccination in both children and adult control groups and patients with primary immunodeficiency (PID). In the control groups, >95% of the individuals had pre Typhi Vi vaccination concentrations <100 U/mL and there was significant increase in concentration post Typhi Vi vaccination (p<0...
June 2017: Heliyon
https://www.readbyqxmd.com/read/28721112/current-perspectives-in-the-usa-on-the-diagnosis-and-treatment-of-pelvic-inflammatory-disease-in-adolescents
#3
REVIEW
William L Risser, Jan M Risser, Amanda L Risser
In this review, the epidemiology, diagnosis, and treatment of pelvic inflammatory disease (PID) are discussed from a USA perspective and the difficulties that USA adolescents face in recognizing and seeking care for PID and other sexually transmitted infections (STIs) are emphasized. Females aged 15-24 years have the highest incidence of cervical infection with Chlamydia trachomatis and Neisseria gonorrheae, the principal causes of PID. PID is common in this age group. However, the incidence of PID in the USA is not known, because it is not a reportable disease, and because clinicians vary in the criteria used for the diagnosis...
2017: Adolescent Health, Medicine and Therapeutics
https://www.readbyqxmd.com/read/28712177/analysis-of-two-years-cases-of-ectopic-pregnancy
#4
Ansa Islam, Aneesa Fawad, Azmat Ali Shah, Humaira Jadoon, Iram Sarwar, Aziz-Un-Nisa Abbasi
BACKGROUND: Ectopic pregnancy is the leading cause of pregnancy related deaths in the first trimester. The aim of this study was to evaluate the frequency of risk factors, clinical presentation, diagnostic methods and site of ectopic pregnancy. METHODS: This descriptive cross sectional study was conducted in Gynaecology and Obstetrical Unit-A of Ayub Teaching Hospital Abbottabad from 1st October 2013 to 31st October 2015. All women diagnosed with ectopic pregnancy were included in the study...
January 2017: Journal of Ayub Medical College, Abbottabad: JAMC
https://www.readbyqxmd.com/read/28709653/set-point-manipulation-approach-towards-online-performance-improvement-in-existing-process-control-loops
#5
Ko Ko Htet Kyaw, Kok Kiong Tan
The majority of current industrial process control systems are based on PID control. However, in many of these systems, once the initial setup has been carried out, it is difficult to implement subsequent continuous improvements on the control performance without shutting down the production and disarming the overall system to retrofit alternative controllers. These measures to integrate additional instruments for allowing such flexibility incur heavy costs in terms of time and resources. In this paper, we propose an approach towards achieving the control adaptations which cannot be achieved easily with an existing closed-architectural system...
July 11, 2017: ISA Transactions
https://www.readbyqxmd.com/read/28708268/screening-protocols-to-monitor-respiratory-status-in-primary-immunodeficiency-disease-findings-from-a-european-survey-and-subclinical-infection-working-group
#6
Stephen Jolles, Silvia Sánchez-Ramón, Isabella Quinti, Pere Soler-Palacín, Carlo Agostini, Benoit Florkin, Louis-Jean Couderc, Nicholas Brodszki, Alison Jones, Hilary Longhurst, Klaus Warnatz, Filomeen Haerynck, Andrea Matucci, Esther de Vries
Many patients with primary immunodeficiency (PID) who have antibody deficiency develop progressive lung disease due to underlying subclinical infection and inflammation. To understand how these patients are monitored we conducted a retrospective survey based on patient records of 13 PID centres across Europe, regarding the care of 1,061 adult and 178 paediatric patients with PID on IgG replacement. The most common diagnosis was common variable immunodeficiency in adults (75%), and hypogammaglobulinaemia in children (39%)...
July 14, 2017: Clinical and Experimental Immunology
https://www.readbyqxmd.com/read/28702026/lessons-from-genetic-studies-of-primary-immunodeficiencies-in-a-highly-consanguineous-population
#7
REVIEW
Mohamed-Ridha Barbouche, Najla Mekki, Meriem Ben-Ali, Imen Ben-Mustapha
During the last decades, the study of primary immunodeficiencies (PIDs) has contributed tremendously to unravel novel pathways involved in a variety of immune responses. Many of these PIDs have an autosomal recessive (AR) mode of inheritance. Thus, the investigation of the molecular basis of PIDs is particularly relevant in consanguineous populations from Middle East and North Africa (MENA). Although significant efforts have been made in recent years to develop genetic testing across the MENA region, few comprehensive studies reporting molecular basis of PIDs in these settings are available...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28697014/valproic-acid-decreases-brain-lesion-size-and-improves-neurologic-recovery-in-swine-subjected-to-traumatic-brain-injury-hemorrhagic-shock-and-polytrauma
#8
Vahagn C Nikolian, Patrick E Georgoff, Manjunath P Pai, Isabel S Dehaney, Kiril Chtraklin, Hassan Eidy, Mohamed Ghandour, Yanyan Han, Ashok Srinivasan, Yongqing Li, Hasan B Alam
BACKGROUND: We have previously shown that treatment with valproic acid (VPA) decreases brain lesion size in swine models of traumatic brain injury (TBI) and controlled hemorrhage. To translate this treatment into clinical practice, validation of drug efficacy and evaluation of pharmacologic properties in clinically realistic models of injury are necessary. In this study, we evaluate neurologic outcomes and perform pharmacokinetic analysis of a single dose of VPA in swine subjected to TBI, hemorrhagic shock, and visceral hemorrhage...
July 8, 2017: Journal of Trauma and Acute Care Surgery
https://www.readbyqxmd.com/read/28694805/primary-immunodeficiency-diseases-in-highly-consanguineous-populations-from-middle-east-and-north-africa-epidemiology-diagnosis-and-care
#9
REVIEW
Hamoud Al-Mousa, Bandar Al-Saud
Middle East and North Africa region (MENA) populations are of different ethnic origins. Consanguineous marriages are common practice with an overall incidence ranging between 20 and 50%. Primary immunodeficiency diseases (PIDs) are a group of heterogeneous genetic disorders caused by defects in the immune system that predisposes patients to recurrent infections, autoimmune diseases, and malignancies. PIDs are more common in areas with high rates of consanguineous marriage since most have an autosomal recessive mode of inheritance...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28688619/explicit-analytical-tuning-rules-for-digital-pid-controllers-via-the-magnitude-optimum-criterion
#10
Konstantinos G Papadopoulos, Praveen K Yadav, Nikolaos I Margaris
Analytical tuning rules for digital PID type-I controllers are presented regardless of the process complexity. This explicit solution allows control engineers 1) to make an accurate examination of the effect of the controller's sampling time to the control loop's performance both in the time and frequency domain 2) to decide when the control has to be I, PI and when the derivative, D, term has to be added or omitted 3) apply this control action to a series of stable benchmark processes regardless of their complexity...
July 5, 2017: ISA Transactions
https://www.readbyqxmd.com/read/28684198/flow-cytometry-based-diagnosis-of-primary-immunodeficiency-diseases
#11
REVIEW
Hirokazu Kanegane, Akihiro Hoshino, Tsubasa Okano, Takahiro Yasumi, Taizo Wada, Hidetoshi Takada, Satoshi Okada, Motoi Yamashita, Tzu-Wen Yeh, Ryuta Nishikomori, Masatoshi Takagi, Kohsuke Imai, Hans D Ochs, Tomohiro Morio
Primary immunodeficiencies (PIDs) are a heterogeneous group of inherited diseases of the immune system. The definite diagnosis of PID is ascertained by genetic analysis; however, this takes time and is costly. Flow cytometry provides a rapid and highly sensitive tool for diagnosis of PIDs. Flow cytometry can evaluate specific cell populations and subpopulations, cell surface, intracellular and intranuclear proteins, biologic effects associated with specific immune defects, and certain functional immune characteristics, each being useful for the diagnosis and evaluation of PIDs...
July 3, 2017: Allergology International: Official Journal of the Japanese Society of Allergology
https://www.readbyqxmd.com/read/28683953/a-multicentre-prospective-non-randomized-sequential-open-label-trial-to-demonstrate-the-bioequivalence-between-intravenous-immunoglobulin-new-generation-igng-and-standard-iv-immunoglobulin-ivig-in-adult-patients-with-primary-immunodeficiency-pid
#12
J-F Viallard, J-P Brion, M Malphettes, I Durieu, M Gardembas, N Schleinitz, C Hoarau, E Lazaro, S Puget
OBJECTIVES: To demonstrate the bioequivalence between 2 intravenous immunoglobulin (IVIG) preparations, TEGELINE(®) and ClairYg(®), a ready-to-use 5% IVIG, in primary immunodeficiency (PID). Secondary objectives were to assess the efficacy, safety and pharmacokinetics of ClairYg(®). METHODS: Twenty-two adult PID patients receiving stable doses of TEGELINE(®) (5% lyophilized IVIG) were switched to ClairYg(®) for 6 months. ClairYg(®) was administered under the same conditions as TEGELINE(®), either every 3 or 4 weeks...
July 3, 2017: La Revue de Médecine Interne
https://www.readbyqxmd.com/read/28683071/trajectory-following-and-stabilization-control-of-fully-actuated-auv-using-inverse-kinematics-and-self-tuning-fuzzy-pid
#13
Mohanad M Hammad, Ahmed K Elshenawy, M I El Singaby
In this work a design for self-tuning non-linear Fuzzy Proportional Integral Derivative (FPID) controller is presented to control position and speed of Multiple Input Multiple Output (MIMO) fully-actuated Autonomous Underwater Vehicles (AUV) to follow desired trajectories. Non-linearity that results from the hydrodynamics and the coupled AUV dynamics makes the design of a stable controller a very difficult task. In this study, the control scheme in a simulation environment is validated using dynamic and kinematic equations for the AUV model and hydrodynamic damping equations...
2017: PloS One
https://www.readbyqxmd.com/read/28679735/hematopoietic-stem-cell-transplantation-in-29-patients-hemizygous-for-hypomorphic-ikbkg-nemo-mutations
#14
Charline Miot, Kohsuke Imai, Chihaya Imai, Anthony J Mancini, Zeynep Yesim Kucuk, Tokomki Kawai, Ryuta Nishikomori, Etsuro Ito, Isabelle Pellier, Sophie Dupuis Girod, Jeremie Rosain, Shinya Sasaki, Shanmuganathan Chandrakasan, Jana Pachlopnik Schmid, Tsubasa Okano, Estelle Colin, Alberto Olaya-Vargas, Marco Yamazaki-Nakashimada, Waseem Qasim, Sara Espinosa Padilla, Andrea Jones, Alfons Krol, Nyree Cole, Stephen Jolles, Jack Bleesing, Thomas Vraetz, Andrew R Gennery, Mario Abinun, Tayfun Güngör, Beatriz Costa-Carvalho, Antonio Condino-Neto, Paul Veys, Steven M Holland, Gulbu Uzel, Despina Moshous, Benedicte Neven, Stéphane Blanche, Stephan Ehl, Rainer Döffinger, Smita Y Patel, Anne Puel, Jacinta Bustamante, Erwin W Gelfand, Jean-Laurent Casanova, Jordan S Orange, Capucine Picard
X-linked recessive ectodermal dysplasia (EDA) with immunodeficiency (XR-EDA-ID) is a rare primary immunodeficiency (PID) caused by hypomorphic mutations of the IKBKG gene encoding the NEMO protein. This condition displays enormous allelic, immunological, and clinical heterogeneity, and therapeutic decisions are difficult because NEMO operates in both hematopoietic and non-hematopoietic cells. Hematopoietic stem cell transplantation (HSCT) is potentially life-saving, but the small number of case reports available suggests that it has been reserved for only the most severe cases...
July 5, 2017: Blood
https://www.readbyqxmd.com/read/28677349/comparison-of-efficacy-and-safety-of-hyoscine-butylbromide-versus-anisodamine-for-acute-gastric-or-intestinal-spasm-like-pain-a-randomized-double-blind-and-multi-center-phase-iii-trial
#15
Chun Ping Zhu, Fei Jiang, Rong Quan Wang, Xiao Zhong Guo, Xiao Hua Hou, Hong Xu, Ya Zeng, Yi Qi Du, Zhao Shen Li
AIM: Acute gastric or intestinal spasm-like pain is a common symptom in digestive diseases. Hyoscine butylbromide (HBB), an anticholinergic agent, relieves the pain of stomach and bowel cramps by inhibiting smooth muscle contractility. The aim was to compare the efficacy and safety of parenteral HBB versus anisodamine, for acute gastric or intestinal spasm-like pain. METHODS: In this randomized, positive-controlled, double-blind, parallel-group, multi-center non-inferiority trial, 299 Chinese patients were randomly assigned to HBB or anisodamine in a 1:1 ratio...
July 5, 2017: Journal of Digestive Diseases
https://www.readbyqxmd.com/read/28676739/pid-controller-design-for-fes-applied-to-ankle-muscles-in-neuroprosthesis-for-standing-balance
#16
Hossein Rouhani, Michael Same, Kei Masani, Ya Qi Li, Milos R Popovic
Closed-loop controlled functional electrical stimulation (FES) applied to the lower limb muscles can be used as a neuroprosthesis for standing balance in neurologically impaired individuals. The objective of this study was to propose a methodology for designing a proportional-integral-derivative (PID) controller for FES applied to the ankle muscles toward maintaining standing balance for several minutes and in the presence of perturbations. First, a model of the physiological control strategy for standing balance was developed...
2017: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/28674536/primary-immunodeficiency-disorders-in-india-a-situational-review
#17
Ankur Kumar Jindal, Rakesh Kumar Pilania, Amit Rawat, Surjit Singh
Primary immunodeficiency disorders (PIDs) are a group of genetic defects characterized by abnormalities of one or more components of the immune system. While there have been several advances in diagnosis, management, and research in the field of PIDs, they continue to remain underdiagnosed, especially in the less affluent countries. Despite several limitations and challenges, India has advanced significantly in the field of PIDs in the last few years. In this review, we highlight the progress in the field of PIDs in India over the last 25 years, the difficulties faced by clinicians across the country, the current state of PIDs in India and the future prospects...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28669558/intrinsic-and-extrinsic-causes-of-malignancies-in-primary-immunodeficiency-disorders
#18
Fabian Hauck, Rebecca Voss, Christian Urban, Markus G Seidel
Malignancies occur with a higher incidence rate and manifest earlier in life in patients with primary immunodeficiency disorders (PID) than in the general population. However, no universal mechanism of malignancy predisposition in PID can been determined. Despite the strong support for the physiological role of tumor immunosurveillance and increasing success of strategies in immunological tumor therapy, which include checkpoint inhibition, monoclonal antibodies, and engineered T cell antigen receptors, the incidence and pattern of malignancies in PID do not reflect an increased tumor immune escape per se...
June 29, 2017: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28669322/cost-effectiveness-of-microscopy-of-urethral-smears-for-asymptomatic-mycoplasma-genitalium-urethritis-in-men-in-england
#19
Andrew J Sutton, Tracy E Roberts, Louise Jackson, John Saunders, Peter J White, Ruthie Birger, Claudia Estcourt
The objective was to determine whether or not the limited use of urethral microscopy to diagnose asymptomatic and symptomatic non-chlamydial, non-gonococcal urethritis (NCNGU) in men is a cost-effective strategy to avert pelvic inflammatory disease (PID), ectopic pregnancy or infertility in female partners. Outputs from a transmission dynamic model of NCNGU in a population of 16-30 year olds in England simulating the number of consultations, PID cases and patients treated over time amongst others, were used along with secondary data to undertake a cost-effectiveness analysis carried out from a health care provider perspective...
January 1, 2017: International Journal of STD & AIDS
https://www.readbyqxmd.com/read/28659952/alteration-in-auxin-homeostasis-and-signaling-by-overexpression-of-pinoid-kinase-causes-leaf-growth-defects-in-arabidopsis-thaliana
#20
Kumud Saini, Marios N Markakis, Malgorzata Zdanio, Daria M Balcerowicz, Tom Beeckman, Lieven De Veylder, Els Prinsen, Gerrit T S Beemster, Kris Vissenberg
In plants many developmental processes are regulated by auxin and its directional transport. PINOID (PID) kinase helps to regulate this transport by influencing polar recruitment of PIN efflux proteins on the cellular membranes. We investigated how altered auxin levels affect leaf growth in Arabidopsis thaliana. Arabidopsis mutants and transgenic plants with altered PID expression levels were used to study the effect on auxin distribution and leaf development. Single knockouts showed small pleiotropic growth defects...
2017: Frontiers in Plant Science
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