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https://www.readbyqxmd.com/read/28639721/trpv4-channels-contribute-to-calcium-transients-in-astrocytes-and-neurons-during-peri-infarct-depolarizations-in-a-stroke-model
#1
Cordula Rakers, Matthias Schmid, Gabor C Petzold
Stroke is one of the leading causes of death and long-term disability. In the penumbra, that is, the area surrounding the infarct core, peri-infarct depolarizations (PIDs) are accompanied by strong intracellular calcium elevations in astrocytes and neurons, thereby negatively affecting infarct size and clinical outcome. The dynamics of PIDs and the cellular pathways that are involved during PID formation and progression remain incompletely understood. We have previously shown that inositol triphosphate-gated calcium release from internal stores is a major component of PID-related astroglial calcium signals, but whether external calcium influx through membrane-localized channels also contributes to PIDs has remained unclear...
June 22, 2017: Glia
https://www.readbyqxmd.com/read/28638621/the-role-of-dsm-5-borderline-personality-symptomatology-and-traits-in-the-link-between-childhood-trauma-and-suicidal-risk-in-psychiatric-patients
#2
Bo Bach, Rita Fjeldsted
BACKGROUND: Childhood traumas appear to be linked to suicidal behavior. However, the factors that mediate between these two phenomena are not sufficiently understood. Recent findings suggest that borderline personality disorder (BPD) may explain some of the association. METHOD: The present study investigated the potential mediating role of BPD symptomatology and traits between reported childhood trauma and suicidal risk in adult psychiatric outpatients (N = 124)...
2017: Borderline Personality Disorder and Emotion Dysregulation
https://www.readbyqxmd.com/read/28637358/comparative-simulation-study-of-glucose-control-methods-designed-for-use-in-the-intensive-care-unit-setting-via-a-novel-controller-scoring-metric
#3
Jeremy DeJournett, Leon DeJournett
BACKGROUND: Effective glucose control in the intensive care unit (ICU) setting has the potential to decrease morbidity and mortality rates and thereby decrease health care expenditures. To evaluate what constitutes effective glucose control, typically several metrics are reported, including time in range, time in mild and severe hypoglycemia, coefficient of variation, and others. To date, there is no one metric that combines all of these individual metrics to give a number indicative of overall performance...
June 1, 2017: Journal of Diabetes Science and Technology
https://www.readbyqxmd.com/read/28630620/cloud-model-based-artificial-immune-network-for-complex-optimization-problem
#4
Mingan Wang, Shuo Feng, Jianming Li, Zhonghua Li, Yu Xue, Dongliang Guo
This paper proposes an artificial immune network based on cloud model (AINet-CM) for complex function optimization problems. Three key immune operators-cloning, mutation, and suppression-are redesigned with the help of the cloud model. To be specific, an increasing half cloud-based cloning operator is used to adjust the dynamic clone multipliers of antibodies, an asymmetrical cloud-based mutation operator is used to control the adaptive evolution of antibodies, and a normal similarity cloud-based suppressor is used to keep the diversity of the antibody population...
2017: Computational Intelligence and Neuroscience
https://www.readbyqxmd.com/read/28625885/dock8-deficiency-insights-into-pathophysiology-clinical-features-and-management
#5
REVIEW
Catherine M Biggs, Sevgi Keles, Talal A Chatila
Dedicator of Cytokinesis 8 (DOCK8) deficiency is a combined immunodeficiency that exemplifies the broad clinical features of primary immunodeficiencies (PIDs), extending beyond recurrent infections to include atopy, autoimmunity and cancer. It is caused by loss of function mutations in DOCK8, encoding a guanine nucleotide exchange factor highly expressed in lymphocytes that regulates the actin cytoskeleton. Additional roles of DOCK8 have also emerged, including regulating MyD88-dependent Toll-like receptor signaling and the activation of the transcription factor STAT3...
June 15, 2017: Clinical Immunology: the Official Journal of the Clinical Immunology Society
https://www.readbyqxmd.com/read/28623282/a-nationwide-study-of-severe-and-protracted-diarrhoea-in-patients-with-primary-immunodeficiency-diseases
#6
Wen-I Lee, Chien-Chang Chen, Tang-Her Jaing, Liang-Shiou Ou, Chuen Hsueh, Jing-Long Huang
Diarrhoea lasting longer than 14 days and failing to respond to conventional management is defined as severe and protracted diarrhoea (SD). In this study, we investigated the prevalence, pathogens and prognosis of SD in primary immunodeficiency diseases (PIDs). Among 246 patients with predominantly paediatric-onset PIDs from 2003-2015, 21 [Btk (six), IL2RG (four), WASP, CD40L, gp91 (three each), gp47, RAG2 (one each)] and five [CVID (four), SCID (one)] without identified mutations had SD before prophylactic treatment...
June 16, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28605703/potential-effects-of-triclosan-on-spatial-displacement-and-local-population-decline-of-the-fish-poecilia-reticulata-using-a-non-forced-system
#7
Daniel C V R Silva, Cristiano V M Araújo, Julio C López-Doval, Morun B Neto, Flávio T Silva, Teresa C B Paiva, Marcelo L M Pompêo
Triclosan (TCS) is an emerging contaminant of concern in environmental studies due to its potential adverse effects on fish behavior. Since avoidance has been shown to be a relevant behavioral endpoint, our aims were: (i) to determine if TCS is able to trigger an avoidance response in Poecilia reticulata; (ii) to predict the population immediate decline (PID) caused by TCS exposure, by integrating lethality and avoidance responses; and (iii) to verify the overestimation of risk when mortality is assessed under forced exposure...
June 2, 2017: Chemosphere
https://www.readbyqxmd.com/read/28602010/closed-loop-regulation-of-arterial-pressure-after-acute-brain-death
#8
Kristian Soltesz, Trygve Sjöberg, Tomas Jansson, Rolf Johansson, Anders Robertsson, Audrius Paskevicius, Quiming Liao, Guangqi Qin, Stig Steen
The purpose of this concept study was to investigate the possibility of automatic mean arterial pressure (MAP) regulation in a porcine heart-beating brain death (BD) model. Hemodynamic stability of BD donors is necessary for maintaining acceptable quality of donated organs for transplantation. Manual stabilization is challenging, due to the lack of vasomotor function in BD donors. Closed-loop stabilization therefore has the potential of increasing availability of acceptable donor organs, and serves to indicate feasibility within less demanding patient groups...
June 10, 2017: Journal of Clinical Monitoring and Computing
https://www.readbyqxmd.com/read/28601682/flow-cytometric-measurement-of-stat1-and-stat3-phosphorylation-in-cd4-and-cd8-t-cells-clinical-applications-in-pid-diagnostics
#9
Michael Bitar, Andreas Boldt, Stefanie Binder, Michael Borte, Karim Kentouche, Stephan Borte, Ulrich Sack
Flow cytometry-based pSTAT1 and pSTAT3 profiling is an effective diagnostic tool to identify PID patients with aberrations in the STAT1 or STAT3 gene.
June 7, 2017: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28599851/experimental-evaluation-of-control-performance-of-mpc-as-a-regulatory-controller
#10
Mohammad Khan, Malik Tahiyat, Syed Imtiaz, M A A Shoukat Choudhury, Faisal Khan
Proportional-integral-derivative (PID) control is widely practised as the base layer controller in the industry due to its robustness and design simplicity. However, a supervisory control layer over the base layer, namely a model predictive controller (MPC), is becoming increasingly popular with the advent of computer process control. The use of a supervisory layer has led to different control structures. In this study, we perform an objective investigation of several commonly used control structures such as 'Cascaded PI controller', 'DMC cascaded to PI' and 'Direct DMC'...
June 6, 2017: ISA Transactions
https://www.readbyqxmd.com/read/28599675/ykl-40-chitinase-3-like-i-is-expressed-in-a-subset-of-astrocytes-in-alzheimer-s-disease-and-other-tauopathies
#11
Marta Querol-Vilaseca, Martí Colom-Cadena, Jordi Pegueroles, Carla San Martín-Paniello, Jordi Clarimon, Olivia Belbin, Juan Fortea, Alberto Lleó
BACKGROUND: The innate immune system is known to be involved early in the pathogenesis of Alzheimer's disease (AD) and other neurodegenerative disorders. The inflammatory response in the central nervous system can be measured postmortem or through a series of inflammatory mediator surrogates. YKL-40 (also named Chitinase-3-like I) has been frequently investigated in body fluids as a surrogate marker of neuroinflammation in AD and other neurological disorders. However, the expression pattern of YKL-40 in the human brain with neurodegenerative pathology remains poorly investigated...
June 9, 2017: Journal of Neuroinflammation
https://www.readbyqxmd.com/read/28597145/quality-of-life-treatment-beliefs-and-treatment-satisfaction-in-children-treated-for-primary-immunodeficiency-with-scig
#12
Serge Sultan, Émélie Rondeau, Marie-Claude Levasseur, Renée Dicaire, Hélène Decaluwe, Élie Haddad
Despite the development of subcutaneous treatment, children and adolescents with primary immunodeficiency (PID) are vulnerable to a lower quality of life (QoL) than non-clinical participants. Comparisons have been offered in rare reports with limited sample sizes. No description is available of treatment beliefs and treatment satisfaction with standard tools. The objective of this study was to describe a large sample of patients with pediatric PID on QoL, treatment beliefs and satisfaction, and identify perceived benefits and issues of treatment both in children and parents...
June 8, 2017: Journal of Clinical Immunology
https://www.readbyqxmd.com/read/28587173/design-and-implementation-of-a-hypothermic-machine-perfusion-device-for-clinical-preservation-of-isolated-organs
#13
Fei Shen, Ruqiang Yan
The imbalance between limited organ supply and huge potential need has hindered the development of organ-graft techniques. In this paper a low-cost hypothermic machine perfusion (HMP) device is designed and implemented to maintain suitable preservation surroundings and extend the survival life of isolated organs. Four necessary elements (the machine perfusion, the physiological parameter monitoring, the thermostatic control and the oxygenation apparatus) involved in this HMP device are introduced. Especially during the thermostatic control process, a modified Bayes estimation, which introduces the concept of improvement factor, is realized to recognize and reduce the possible measurement errors resulting from sensor faults and noise interference...
June 1, 2017: Sensors
https://www.readbyqxmd.com/read/28584104/phosphorylation-and-negative-regulation-of-constitutively-photomorphogenic-1-by-pinoid-in-arabidopsis
#14
Fang Lin, Dongqing Xu, Yan Jiang, Haodong Chen, Liumin Fan, Magnus Holm, Xing Wang Deng
CONSTITUTIVELY PHOTOMORPHOGENIC 1 (COP1) plays crucial roles in various cellular processes via its E3 ubiquitin ligase activity in organisms, ranging from fungi to humans. As a key component in regulating various biological events, COP1 itself is precisely controlled at multiple layers. Here, we report a negative regulator of COP1, PINOID (PID), which positively mediates photomorphogenic development. Specifically, PID genetically and physically interacts with COP1 and directly phosphorylates COP1 at Ser20. As a result, this posttranslational modification serves to repress COP1 activity and promote photomorphogenesis...
June 20, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28583349/design-and-implementation-of-ep-based-pid-controller-for-chaos-synchronization-of-rikitake-circuit-systems
#15
Yi-You Hou
This article addresses an evolutionary programming (EP) algorithm technique-based and proportional-integral-derivative (PID) control methods are established to guarantee synchronization of the master and slave Rikitake chaotic systems. For PID synchronous control, the evolutionary programming (EP) algorithm is used to find the optimal PID controller parameters kp, ki, kd by integrated absolute error (IAE) method for the convergence conditions. In order to verify the system performance, the basic electronic components containing operational amplifiers (OPAs), resistors, and capacitors are used to implement the proposed chaotic Rikitake systems...
June 2, 2017: ISA Transactions
https://www.readbyqxmd.com/read/28557479/development-and-validation-of-an-overreporting-scale-for-the-personality-inventory-for-dsm-5-pid-5
#16
Martin Sellbom, Sonya Dhillon, R Michael Bagby
Our aim in the current study was to develop a validity scale for the Personality Inventory for DSM-5 (PID-5) to detect noncredible overreported responding. To this end, we used a rare symptoms approach and identified extreme response options on PID-5 items that were infrequently endorsed by students in 3 different university samples (N = 1,370) and in a psychiatric patient sample (N = 194). The resulting 10-item scale (the PID-5-ORS) produced adequate-to-good estimates of internal reliability and was significantly correlated with the Minnesota Multiphasic Personality Inventory-2 Restructued Form (MMPI-2-RF) overreporting validity scales, providing evidence of concurrent validity...
May 29, 2017: Psychological Assessment
https://www.readbyqxmd.com/read/28556817/the-lateral-tracking-control-for-the-intelligent-vehicle-based-on-adaptive-pid-neural-network
#17
Gaining Han, Weiping Fu, Wen Wang, Zongsheng Wu
The intelligent vehicle is a complicated nonlinear system, and the design of a path tracking controller is one of the key technologies in intelligent vehicle research. This paper mainly designs a lateral control dynamic model of the intelligent vehicle, which is used for lateral tracking control. Firstly, the vehicle dynamics model (i.e., transfer function) is established according to the vehicle parameters. Secondly, according to the vehicle steering control system and the CARMA (Controlled Auto-Regression and Moving-Average) model, a second-order control system model is built...
May 30, 2017: Sensors
https://www.readbyqxmd.com/read/28555275/control-of-force-during-rapid-visuomotor-force-matching-tasks-can-be-described-by-discrete-time-pid-control-algorithms
#18
Jakob Lund Dideriksen, Daniel F Feeney, Awad M Almuklass, Roger M Enoka
Force trajectories during isometric force-matching tasks involving isometric contractions vary substantially across individuals. In this study, we investigated if this variability can be explained by discrete time proportional, integral, derivative (PID) control algorithms with varying model parameters. To this end, we analyzed the pinch force trajectories of 24 subjects performing two rapid force-matching tasks with visual feedback. Both tasks involved isometric contractions to a target force of 10% maximal voluntary contraction...
May 29, 2017: Experimental Brain Research. Experimentelle Hirnforschung. Expérimentation Cérébrale
https://www.readbyqxmd.com/read/28552805/novel-rag1-mutation-and-the-occurrence-of-mycobacterial-and-chromobacterium-violaceum-infections-in-a-case-of-leaky-scid
#19
Taj Ali Khan, Asif Iqbal, Hazir Rahman, Otavio Cabral-Marques, Muhammad Ishfaq, Noor Muhammad
Severe combined immunodeficiency (SCID) is a potentially fatal primary immunodeficiency (PID) that is caused by mutations in genes such as IL2RG, JAK3, IL7RA, RAG1, RAG2, and ADA. The products of these genes are involved in the development of several immune cells such as T, B and natural killer (NK) cells. Most of the SCID forms are autosomal recessive with the exception of IL2RG defects that cause an X-linked SCID. Among the different SCID types, there is a rare SCID form called leaky SCID, which is less severe when compared to the other classical SCID phenotypes...
May 25, 2017: Microbial Pathogenesis
https://www.readbyqxmd.com/read/28530723/precision-control-of-flow-rate-in-microfluidic-channels-using-photoresponsive-soft-polymer-actuators
#20
Colm Delaney, Peter McCluskey, Simon Coleman, Jeffrey Whyte, Nigel Kent, Dermot Diamond
A novel approach that allows control of flow in microfluidic channels with unsurpassed performance using light is described. Valve structures have been created using photoresponsive hydrogels based on spiropyran-functionalised pNIPAAm hydrogels photopolymerised around pillar structures within the channels. Valve actuation is controlled from outside the fluidic system using externally located LEDs. Highly precise and accurate flow rates can be selected by passing real-time flow rate measurements into a PID algorithm...
May 31, 2017: Lab on a Chip
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