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https://www.readbyqxmd.com/read/28930011/poliovirus-excretion-in-children-with-primary-immunodeficiency-disorders-india
#1
Madhu Chhanda Mohanty, Manisha Rajan Madkaikar, Mukesh Desai, Prasad Taur, Uma Prajwal Nalavade, Deepa Kailash Sharma, Maya Gupta, Aparna Dalvi, Snehal Shabrish, Manasi Kulkarni, Jahnavi Aluri, Jagadish Mohanrao Deshpande
Prolonged excretion of poliovirus can occur in immunodeficient patients who receive oral polio vaccine, which may lead to propagation of highly divergent vaccine-derived polioviruses (VDPVs), posing a concern for global polio eradication. This study aimed to estimate the proportion of primary immunodeficient children with enterovirus infection and to identify the long-term polio/nonpolio enterovirus excreters in a tertiary care unit in Mumbai, India. During September 2014-April 2017, 151 patients received diagnoses of primary immunodeficiency (PID)...
October 2017: Emerging Infectious Diseases
https://www.readbyqxmd.com/read/28928322/assessment-of-urinary-cotinine-levels-in-women-with-gynecological-complaints-at-a-tertiary-care-hospital-a-pilot-study
#2
A G Radhika, Sruthi Bhaskaran, Jagdish Kaur, Anshuja Singla, Tusha Sharma, B D Banerjee
Gynecological effects due to smokeless tobacco exposure are not well studied. This cross-sectional study was undertaken with the objective to evaluate the urinary cotinine levels in women of reproductive age with gynecological complaints. The study was conducted in 2015 at the outpatient clinic of the Department of Obstetrics and Gynecology, University College of Medical Sciences and Guru Teg Bahadur Hospital, Delhi. A total of 192 consecutive women presenting with gynecological complaints (pelvic inflammatory disease (PID), infertility, and menstrual abnormality) were recruited...
September 2017: Indian Journal of Public Health
https://www.readbyqxmd.com/read/28926878/-effects-of-arnebia-root-oil-on-wound-healing-of-rats-with-full-thickness-skin-defect-and-the-related-mechanism
#3
J Y Shen, Q Ma, Z B Yang, J J Gong, Y S Wu
Objective: To observe the effects of arnebia root oil on wound healing of rats with full-thickness skin defect, and to explore the related mechanism. Methods: Eighty SD rats were divided into arnebia root oil group and control group according to the random number table, with 40 rats in each group, then full-thickness skin wounds with area of 3 cm×3 cm were inflicted on the back of each rat. Wounds of rats in arnebia root oil group and control group were treated with sterile medical gauze and bandage package infiltrated with arnebia root oil gauze or Vaseline gauze, respectively, with dressing change of once every two days...
September 20, 2017: Zhonghua Shao Shang za Zhi, Zhonghua Shaoshang Zazhi, Chinese Journal of Burns
https://www.readbyqxmd.com/read/28922955/comparison-of-zfns-versus-crispr-specific-nucleases-for-genome-edition-of-the-wiskott-aldrich-syndrome-locus
#4
Alejandra Gutierrez-Guerrero, Sabina Sanchez-Hernandez, Giuseppe Galvani, Javier Pinedo-Gomez, Almudena Sanchez-Gilabert, Rocio Martin-Guerra, Marien Cobo, Philip Gregory, Michael Holmes, Karim Benabdellah, Francisco Martin
Primary immunodeficiencies (PID), including Wiskott-Aldrich syndrome (WAS), are a main target for genome editing (GE) strategies using specific nucleases (SNs) since a small number of corrected hematopoietic stem cells (HSCs) could cure patients. In this work, we have designed different WAS gene-specific CRISPR/Cas9 systems and compared their efficiency and specificity with homodimeric and heterodimeric WAS-specific Zinc Finger Nucleases (ZFNs) using K562 cells as a cellular model and plasmid nucleofection or integrative-deficient Lentiviral Vectors (IDLVs) for delivery...
September 19, 2017: Human Gene Therapy
https://www.readbyqxmd.com/read/28919286/a-novel-optimized-hybrid-fuzzy-logic-intelligent-pid-controller-for-an-interconnected-multi-area-power-system-with-physical-constraints-and-boiler-dynamics
#5
A H Gomaa Haroun, Yin-Ya Li
In the fast developing world nowadays, load frequency control (LFC) is considered to be a most significant role for providing the power supply with good quality in the power system. To deliver a reliable power, LFC system requires highly competent and intelligent control technique. Hence, in this article, a novel hybrid fuzzy logic intelligent proportional-integral-derivative (FLiPID) controller has been proposed for LFC of interconnected multi-area power systems. A four-area interconnected thermal power system incorporated with physical constraints and boiler dynamics is considered and the adjustable parameters of the FLiPID controller are optimized using particle swarm optimization (PSO) scheme employing an integral square error (ISE) criterion...
September 14, 2017: ISA Transactions
https://www.readbyqxmd.com/read/28918061/improved-fuzzy-pid-controller-design-using-predictive-functional-control-structure
#6
Yuzhong Wang, Qibing Jin, Ridong Zhang
In conventional PID scheme, the ensemble control performance may be unsatisfactory due to limited degrees of freedom under various kinds of uncertainty. To overcome this disadvantage, a novel PID control method that inherits the advantages of fuzzy PID control and the predictive functional control (PFC) is presented and further verified on the temperature model of a coke furnace. Based on the framework of PFC, the prediction of the future process behavior is first obtained using the current process input signal...
September 13, 2017: ISA Transactions
https://www.readbyqxmd.com/read/28916318/matrix-metalloproteinases-2-and-9-in-campylobacter-jejuni-induced-paralytic-neuropathy-resembling-guillain-barr%C3%A3-syndrome-in-chickens
#7
Kishan Kumar Nyati, Kashi Nath Prasad, Vinita Agrawal, Nuzhat Husain
Inflammation in Guillain-Barré syndrome (GBS) is manifested by changes in matrix metalloproteinase (MMP) and pro-inflammatory cytokine expression. We investigated the expression of MMP-2, -9 and TNF-α and correlated it with pathological changes in sciatic nerve tissue from Campylobacter jejuni-induced chicken model for GBS. Campylobacter jejuni and placebo were fed to chickens and assessed for disease symptoms. Sciatic nerves were examined by histopathology and immunohistochemistry. Expressions of MMPs and TNF-α, were determined by real-time PCR, and activities of MMPs by zymography...
September 12, 2017: Microbial Pathogenesis
https://www.readbyqxmd.com/read/28915869/frequency-and-genotypes-of-chlamydia-trachomatis-in-patients-attending-the-obstetrics-and-gynecology-clinics-in-jalisco-mexico-and-correlation-with-sociodemographic-behavioral-and-biological-factors
#8
Néstor Casillas-Vega, Rayo Morfín-Otero, Santos García, Jorge Llaca-Díaz, Eduardo Rodríguez-Noriega, Adrián Camacho-Ortiz, Ma de la Merced Ayala-Castellanos, Héctor J Maldonado-Garza, Jesús Ancer-Rodríguez, Guadalupe Gallegos-Ávila, Alberto Niderhauser-García, Elvira Garza-González
BACKGROUND: Chlamydia trachomatis is the causative agent of the most common bacterial sexually transmitted infection worldwide. The aim of this study was to investigate the frequency and genotypes of C. trachomatis in patients attending an obstetrics and gynecology clinic in Jalisco, Mexico and correlates them with sociodemographic, behavioral, and biological factors. METHODS: C. trachomatis detection was performed in endocervical samples from 662 patients by direct fluorescence assay (DFA) and two PCR assays that amplified the phospholipase D endonuclease superfamily protein (PLDESP) and OmpA genes...
September 15, 2017: BMC Women's Health
https://www.readbyqxmd.com/read/28902066/latent-class-analysis-of-adhd-neurodevelopmental-and-mental-health-comorbidities
#9
Benjamin Zablotsky, Matthew D Bramlett, Susanna N Visser, Melissa L Danielson, Stephen J Blumberg
OBJECTIVE: Many children diagnosed with attention-deficit/hyperactivity disorder (ADHD) experience co-occurring neurodevelopmental and psychiatric disorders, and those who do often exhibit higher levels of impairment than children with ADHD alone. This study provides a latent class analysis (LCA) approach to categorizing children with ADHD into comorbidity groups, evaluating condition expression and treatment patterns in each group. METHODS: Parent-reported data from a large probability-based national sample of children diagnosed with ADHD (2014 National Survey of the Diagnosis and Treatment of ADHD and Tourette Syndrome) were used for an LCA to identify groups of children with similar groupings of neurodevelopmental and psychiatric comorbidities among children with current ADHD (n = 2495)...
September 8, 2017: Journal of Developmental and Behavioral Pediatrics: JDBP
https://www.readbyqxmd.com/read/28901730/reduced-toxicity-alternate-donor-stem-cell-transplantation-with-posttransplant-cyclophosphamide-for-primary-immunodeficiency-disorders
#10
Neha Rastogi, Satyendra Katewa, Dhwanee Thakkar, Shruti Kohli, Sagar Nivargi, Satya Prakash Yadav
We describe here the outcomes of reduced-toxicity alternate-donor stem cell transplant (SCT) with posttransplant cyclophosphamide (PTCy) for primary immunodeficiency disorders (PIDs) in eight children (haploidentical-seven and matched unrelated donor-one). The conditioning was with serotherapy (alemtuzumab-3/rabbit-anti-thymoglobulin-5); fludarabine, cyclophosphamide, and total body irradiation-5 (additional thiotepa-3); fludarabine and treosulfan-2; and fludarabine and busulfan-1. All received PTCy 50 mg/kg on days 3 and 4 as graft versus host disease prophylaxis along with tacrolimus and mycophenolate...
September 13, 2017: Pediatric Blood & Cancer
https://www.readbyqxmd.com/read/28900865/genetic-counseling-in-primary-immunodeficiency-disorders-an-emerging-experience-in-egypt
#11
Rabab E El Hawary, Safa S Meshaal, Dalia S Abd Elaziz, Marwa A Elsharkawy, Radwa S Alkady, Sohilla Lotfy, Ahmad El-Sheikhah, Amr Hassan, Nermeen M Galal, Jeannette A Boutros, Aisha M Elmarsafy
BACKGROUND: Primary immunodeficiency disorders (PIDs) are a heterogeneous group of diseases of the immune system leading to life-threatening infections, and, unless urgently treated with immune reconstitution, patients do not usually survive. With the continuing progress in molecular diagnosis, many mutations have been described in more than 300 genes. Genetic counseling has recently been considered an essential part of the management of PIDs. This study presents the experience of genetic counseling services in the largest PID center in Egypt, and reports on our management plan and the impact of prenatal diagnosis (PND) on families...
September 12, 2017: Molecular Diagnosis & Therapy
https://www.readbyqxmd.com/read/28899577/real-time-discrete-suboptimal-control-for-systems-with-input-and-state-delays-experimental-tests-on-a-dehydration-process
#12
Liliam Rodríguez-Guerrero, Omar-Jacobo Santos-Sánchez, Nicolás Cervantes-Escorcia, Hugo Romero
This article presents a suboptimal control strategy with finite horizon for affine nonlinear discrete systems with both state and input delays. The Dynamic Programming Approach is used to obtain the suboptimal control sequence, but in order to avoid the computation of the Bellman functional, a numerical approximation of this function is proposed in every step. The feasibility of our proposal is demonstrated via an experimental test on a dehydration process and the obtained results show a good performance and behavior of this process...
September 9, 2017: ISA Transactions
https://www.readbyqxmd.com/read/28894927/how-to-differentiate-acute-pelvic-inflammatory-disease-from-acute-appendicitis-a-decision-tree-based-on-ct-findings
#13
Kim El Hentour, Ingrid Millet, Emmanuelle Pages-Bouic, Fernanda Curros-Doyon, Nicolas Molinari, Patrice Taourel
PURPOSE: To construct a decision tree based on CT findings to differentiate acute pelvic inflammatory disease (PID) from acute appendicitis (AA) in women with lower abdominal pain and inflammatory syndrome. MATERIALS AND METHODS: This retrospective study was approved by our institutional review board and informed consent was waived. Contrast-enhanced CT studies of 109 women with acute PID and 218 age-matched women with AA were retrospectively and independently reviewed by two radiologists to identify CT findings predictive of PID or AA...
September 11, 2017: European Radiology
https://www.readbyqxmd.com/read/28876962/gastrointestinal-manifestations-of-primary-immune-deficiencies-in-children
#14
Naila Nazi, Fani Ladomenou
Primary immune deficiencies (PID) in children are a rare but serious group of genetic disorders of the immune system which apart from the host's defenses, can also affect every system of the human body, including the gastrointestinal tract. In their severe form they can lead to increased susceptibility to serious infections during infancy and even death. In the less severe form, they can present later in childhood or adolescence with subtle signs and symptoms. As PID can often mimic gastrointestinal diseases, children presenting with atypical gastrointestinal disease and/or failure to respond to conventional therapy should be evaluated for an underlying primary immune disorder and initiated appropriate treatment...
September 6, 2017: International Reviews of Immunology
https://www.readbyqxmd.com/read/28875839/repositioning-drugs-for-rare-immune-diseases-hopes-and-challenges-for-a-precision-medicine
#15
Erica Valencic, Alenka Smid, Ziga Jakopin, Alberto Tommasini, Irena Mlinaric-Rascan
Human primary immunodeficiency diseases (PIDs) are a large group of rare diseases and are characterized by a great genetic and phenotypic heterogeneity. A large subset of PIDs is genetically defined, which has a crucial impact for the understanding of the molecular basis of disease and the development of precision medicine. Discovery and development of new therapies for rare diseases has long been de-privileged due to the length and cost of the processes involved. Interest has increased due to stimulatory regulatory and supportive reimbursement environments enabling viable business models...
August 29, 2017: Current Medicinal Chemistry
https://www.readbyqxmd.com/read/28868834/recurrent-vulvovaginal-candidiasis-could-it-be-related-to-cell-mediated-immunity-defect-in-response-to-candida-antigen
#16
Zahra Talaei, Saba Sheikhbahaei, Vajihe Ostadi, Mazdak Ganjalikhani Hakemi, Mohsen Meidani, Elham Naghshineh, Majid Yaran, Alireza Emami Naeini, Roya Sherkat
Background: Recurrent vulvovaginal candidiasis (RVVC) is a common cause of morbidity affecting millions of women worldwide. Patients with RVVC are thought to have an underlying immunologic defect. This study has been established to evaluate cell-mediated immunity defect in response to candida antigen in RVVC cases. MATERIALS AND METHODS: Our cross-sectional study was performed in 3 groups of RVVC patients (cases), healthy individuals (control I) and known cases of chronic mucocutaneous candidiasis (CMC) (control II)...
October 2017: International Journal of Fertility & Sterility
https://www.readbyqxmd.com/read/28838078/mycoplasma-genitalium-in-women-current-knowledge-and-research-priorities-for-this-recently-emerged-pathogen
#17
REVIEW
Harold C Wiesenfeld, Lisa E Manhart
Health consequences of sexually transmitted diseases disproportionately affect women, making it important to determine whether newly emerged pathogens cause sequelae. Although the pathogenic role of Mycoplasma genitalium in male urethritis is clear, fewer studies have been conducted among women to determine its pathogenic role in the female reproductive tract. Pelvic inflammatory disease (PID) is an important cause of infertility and ectopic pregnancy, and Chlamydia trachomatis and Neisseria gonorrhoeae are recognized microbial causes...
July 15, 2017: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/28838072/mycoplasma-genitalium-accurate-diagnosis-is-necessary-for-adequate-treatment
#18
REVIEW
Charlotte A Gaydos
Background: Mycoplasma genitalium is very difficult to grow in culture but has been more able to be studied for disease associations since the advent of research molecular amplification assays. Polymerase chain reaction (PCR) and other molecular assays have demonstrated an association with adverse disease outcomes, such as urethritis or nongonococcal urethritis in men and adverse reproductive sequelae in women-for example, cervicitis, endometritis, and pelvic inflammatory disease (PID), including an association with risk for human immunodeficiency virus...
July 15, 2017: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/28833245/the-psychometric-properties-of-the-portuguese-version-of-the-personality-inventory-for-dsm-5
#19
Rute Pires, Ana Sousa Ferreira, David Guedes
The DSM-5 Section III proposes a hybrid dimensional-categorical model of conceptualizing personality and its disorders that includes assessment of impairments in personality functioning (criterion A) and maladaptive personality traits (criterion B). The Personality Inventory for the DSM-5 is a new dimensional tool, composed of 220 items organized into 25 facets that delineate five higher order domains of clinically relevant personality differences, and was developed to operationalize the DSM-5 model of pathological personality traits...
August 22, 2017: Scandinavian Journal of Psychology
https://www.readbyqxmd.com/read/28828251/periodontal-inflammatory-disease-is-associated-with-the-risk-of-parkinson-s-disease-a-population-based-retrospective-matched-cohort-study
#20
Chang-Kai Chen, Yung-Tsan Wu, Yu-Chao Chang
BACKGROUND: The cause-effect relation between periodontal inflammatory disease (PID) and Parkinson's disease (PD) remains uncertain. The purpose of our study was to investigate the association between PID and PD. METHODS: We conducted a retrospective matched-cohort study by using Taiwan's National Health Insurance Research Database. We identified 5,396 patients with newly diagnosed PID during 1997-2004 and 10,792 cases without PID by matching sex, age, index of year (occurrence of PID), and comorbidity...
2017: PeerJ
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