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https://www.readbyqxmd.com/read/29346512/validation-of-the-pids-idsa-severity-criteria-in-children-with-community-acquired-pneumonia
#1
Todd A Florin, Cole Brokamp, Rachel Mantyla, Bradley DePaoli, Richard Ruddy, Samir S Shah, Lilliam Ambroggio
Background: The Pediatric Infectious Diseases Society (PIDS)/Infectious Diseases Society of America (IDSA) guideline for community-acquired pneumonia (CAP) recommends intensive care unit (ICU) admission or continuous monitoring for children meeting severity criteria. Our objective was to validate these criteria. Methods: This was a retrospective cohort study of children age 3 months-18 years diagnosed with CAP in a pediatric Emergency Department (ED) from 9/2014-8/2015...
January 13, 2018: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/29345621/the-circulating-t-helper-subsets-and-regulatory-t-cells-in-patients-with-common-variable-immunodeficiency-with-no-known-monogenic-disease
#2
G Azizi, A Mirshafiey, H Abolhassani, R Yazdani, F J Ansariha, M Shaghaghi, S S Mortazavi-Jahromi, F Noorbakhsh, N Rezaei, A Aghamohammadi
BACKGROUND: Common variable immunodeficiency (CVID) is the most common symptomatic primary immunodeficiency (PID), characterized by heterogeneous clinical manifestations and defects in B- and T- cells. In the present study, we investigated the T helper (Th) cell subsets and regulatory T (Treg) cells, and their related cytokines and transcription factors in the CVID patients with no definite genetic diagnosis. METHODS: The study population comprised 13 CVID patients and 13 healthy controls (HC)...
January 18, 2018: Journal of Investigational Allergology & Clinical Immunology
https://www.readbyqxmd.com/read/29335666/a-modified-dynamic-surface-controller-for-delayed-neuromuscular-electrical-stimulation
#3
Naji Alibeji, Nicholas Kirsch, Brad E Dicianno, Nitin Sharma
A widely accepted model of muscle force generation during neuromuscular electrical stimulation (NMES) is a second-order nonlinear musculoskeletal dynamics cascaded to a delayed first-order muscle activation dynamics. However, most nonlinear NMES control methods have either neglected the muscle activation dynamics or used an ad hoc strategies to tackle the muscle activation dynamics, which may not guarantee control stability. We hypothesized that a nonlinear control design that includes muscle activation dynamics can improve the control performance...
August 2017: IEEE/ASME Transactions on Mechatronics
https://www.readbyqxmd.com/read/29333991/evaluation-of-a-portable-gas-chromatograph-with-photoionization-detector-under-variations-of-voc-concentration-temperature-and-relative-humidity
#4
Jhy-Charm Soo, Eun Gyung Lee, Ryan F LeBouf, Michael L Kashon, William Chisholm, Martin Harper
The objective of this present study was to evaluate the performance of a portable gas chromatograph ─ photoionization detector (GC-PID), under various test conditions to determine if it could be used in occupational settings. A mixture of seven volatile organic compounds (VOCs) - acetone, ethylbenzene, methyl isobutyl ketone, toluene, m-xylene, p-xylene, and o-xylene - was selected because its components are commonly present in paint manufacturing industries. A full-factorial combination of four concentration levels (exposure scenarios) of VOC mixtures, three different temperatures (25˚C, 30˚C, and 35˚C), and three relative humidities (RHs; 25%, 50%, and 75%) was conducted in a full- size controlled environmental chamber...
January 15, 2018: Journal of Occupational and Environmental Hygiene
https://www.readbyqxmd.com/read/29325543/persistent-mammalian-orthoreovirus-coxsackievirus-and-adenovirus-co-infection-in-a-child-with-a-primary-immunodeficiency-detected-by-metagenomic-sequencing-a-case-report
#5
Dagmara W Lewandowska, Riccarda Capaul, Seraina Prader, Osvaldo Zagordi, Fabienne-Desirée Geissberger, Martin Kügler, Marcus Knorr, Christoph Berger, Tayfun Güngör, Janine Reichenbach, Cyril Shah, Jürg Böni, Andrea Zbinden, Alexandra Trkola, Jana Pachlopnik Schmid, Michael Huber
BACKGROUND: We report a rare case of Mammalian orthoreovirus (MRV) infection in a child with a primary immunodeficiency (PID). Infections with Mammalian orthoreovirus are very rare and probably of zoonotic origin. Only a few cases have been described so far, including one with similar pathogenesis as in our case. CASE PRESENTATION: The patient, age 11, presented with flu-like symptoms and persistent severe diarrhea. Enterovirus has been detected over several months, however, exact typing of a positive cell culture remained inconclusive...
January 11, 2018: BMC Infectious Diseases
https://www.readbyqxmd.com/read/29323514/ffmpd-scales-comparisons-with-the-ffm-pid-5-and-cat-pd-sf
#6
Cristina Crego, Joshua R Oltmanns, Thomas A Widiger
A series of 8 Five Factor Model Personality Disorder (FFMPD) scales have been developed to assess, from the perspective of the Five Factor Model (FFM), the maladaptive traits included within DSM-5 Section II personality disorders. An extensive body of FFMPD research has accumulated. However, for the most part, each study has been confined to the scales within 1 particular FFMPD Inventory. The current study considered 36 FFMPD scales, at least 1 from each of the 8 FFMPD inventories, including 8 scales considered to be from neuroticism, 8 from extraversion, 5 from openness, 8 from agreeableness, and 7 from conscientiousness...
January 2018: Psychological Assessment
https://www.readbyqxmd.com/read/29322346/study-on-the-incidence-and-influences-on-heterotopic-pregnancy-from-embryo-transfer-of-fresh-cycles-and-frozen-thawed-cycles
#7
Shan Xiao, Meilan Mo, Xiaodong Hu, Hongzhan Zhang, Shiru Xu, Zhuran Wang, Yong Zeng
PURPOSE: The purpose of this study was to determine the heterotopic pregnancy rate using fresh versus frozen-thawed embryo transfers and factors associated with heterotopic pregnancy (HP). Management and clinical outcomes after heterotopic pregnancy were also evaluated. METHODS: In this retrospective cohort study, we included 12,484 women who had clinical pregnancies after in vitro fertilization treatment at our fertility center between 2012 and 2017. Patients received fresh day 3 embryos (F-D3 group), fresh day 5 blastocysts (F-D5 group), frozen-thawed day 3 embryos (T-D3 group), or frozen-thawed day 5 or 6 blastocysts (T-D5/6 groups) transfers...
January 11, 2018: Journal of Assisted Reproduction and Genetics
https://www.readbyqxmd.com/read/29310365/ebv-lymphoproliferative-associated-disease-and-primary-cardiac-t-cell-lymphoma-in-a-stk4-deficient-patient-a-case-report
#8
Roya Sherkat, Mohammad Reza Sabri, Bahar Dehghan, Hamid Bigdelian, Nahid Reisi, Nooshin Afsharmoghadam, Hamid Rahimi, Narges Rahmanian, Cristoph Klein
RATIONALE: Primary cardiac lymphoma (PLC) is an extremely uncommon malignancy. PCL is more common in secondary immunodeficient patients. In this report, we describe a unique case of PLC who had been diagnosed as a STK4 deficient patient. This case is the first Primary immunodeficiency (PID) patient developing PCL in the world. PATIENT CONCERNS: An eleven-year-old girl, a known case of PID, was referred to the pediatric cardiology department because of chest pain and dyspnea...
December 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29307028/exercise-perception-and-behaviors-in-individuals-living-with-primary-immunodeficiency-disease
#9
Kerri L Sowers, Bini A Litwin, Alan C W Lee, Mary Lou A Galantino
BACKGROUND: Routine exercise has been established as an effective way to improve overall health. The value of exercise has been established in many diseases, however, there are no studies investigating the impact of exercise for individuals with primary immunodeficiency disease (PID). The purpose of this study was to investigate exercise perceptions and behaviors in individuals diagnosed with PID. METHODS: An online survey was distributed over a four-week period...
January 6, 2018: Journal of Clinical Immunology
https://www.readbyqxmd.com/read/29300535/hematopoietic-cell-transplantation-in-primary-immunodeficiency-conventional-and-emerging-indications
#10
Mary A Slatter, Andrew R Gennery
Haematopoietic stem cell transplantation (HSCT) is an established curative treatment for many primary immunodeficiencies. Advances in donor selection, graft manipulation, conditioning and treatment of complications, mean that survival for many conditions is now around 90%. Next generation sequencing is identifying new immunodeficiencies, many of which are treatable with HSCT. Challenges remain however with short and long-term sequalae. This article reviews latest developments in HSCT for conventional primary immunodeficiencies and presents data on outcome for emerging diseases, Areas covered: This article reviews recently published literature detailing advances, particularly in conditioning regimens and new methods of T-lymphocyte depletion, as well as new information regarding approach and out come of transplanting patients with conventional primary immunodeficiencies...
January 4, 2018: Expert Review of Clinical Immunology
https://www.readbyqxmd.com/read/29297138/design-of-a-noninvasive-and-smart-hand-tremor-attenuation-system-with-active-control-a-simulation-study
#11
Mahdi Abbasi, Aref Afsharfard, Roya Arasteh, Javad Safaie
This paper presents the design and simulation of a handheld device for people with hand tremor, such as Parkinson's and essential tremor patients. This device can be used as a pen for smartphones or as a spoon. The designed system includes two links, which are connected to two servomotors, which are mounted in orthogonal directions. To attenuate the effect of hand tremor on the tip of device, PID and computed torque methods are used to actively control the system. These controllers are used to control the rotation of the motors for moving the links in opposite directions of the hand tremor...
January 3, 2018: Medical & Biological Engineering & Computing
https://www.readbyqxmd.com/read/29289234/digitally-controlled-analog-proportional-integral-derivative-pid-controller-for-high-speed-scanning-probe-microscopy
#12
Maja Dukic, Vencislav Todorov, Santiago Andany, Adrian P Nievergelt, Chen Yang, Nahid Hosseini, Georg E Fantner
Nearly all scanning probe microscopes (SPMs) contain a feedback controller, which is used to move the scanner in the direction of the z-axis in order to maintain a constant setpoint based on the tip-sample interaction. The most frequently used feedback controller in SPMs is the proportional-integral (PI) controller. The bandwidth of the PI controller presents one of the speed limiting factors in high-speed SPMs, where higher bandwidths enable faster scanning speeds and higher imaging resolution. Most SPM systems use digital signal processor-based PI feedback controllers, which require analog-to-digital and digital-to-analog converters...
December 2017: Review of Scientific Instruments
https://www.readbyqxmd.com/read/29289182/kriging-modeling-and-spsa-adjusting-pid-with-kpwf-compensator-control-of-ipmc-gripper-for-mm-sized-objects
#13
Yang Chen, Lina Hao, Hui Yang, Jinhai Gao
Ionic polymer metal composite (IPMC) as a new smart material has been widely concerned in the micromanipulation field. In this paper, a novel two-finger gripper which contains an IPMC actuator and an ultrasensitive force sensor is proposed and fabricated. The IPMC as one finger of the gripper for mm-sized objects can achieve gripping and releasing motion, and the other finger works not only as a support finger but also as a force sensor. Because of the feedback signal of the force sensor, this integrated actuating and sensing gripper can complete gripping miniature objects in millimeter scale...
December 2017: Review of Scientific Instruments
https://www.readbyqxmd.com/read/29287941/risk-of-pelvic-inflammatory-disease-after-intrauterine-insemination-a-systematic-review
#14
REVIEW
Roberto Matorras, Kristian Rubio, María Iglesias, Itziar Vara, Antonia Expósito
The aim of this study was to ascertain the incidence of pelvic inflammatory disease (PID) after intrauterine insemination (IUI). A systematic review was conducted using three different approaches: a search of IUI registries; a search of published meta-analyses; and a search of prospective randomized trials. Search terms were 'IUI', 'complications', 'infection' and 'PID'. Two IUI registers were identified that met the inclusion criteria, totalling 365,874 cycles, with 57 PID cases being reported. The post-IUI PID rate was 0...
November 24, 2017: Reproductive Biomedicine Online
https://www.readbyqxmd.com/read/29286178/toll-like-receptor-variants-and-cervical-atopobium-vaginae-infection-in-women-with-pelvic-inflammatory-disease
#15
Brandie D Taylor, Patricia A Totten, Sabina G Astete, Michael J Ferris, David H Martin, Roberta B Ness, Catherine L Haggerty
PROBLEM: Toll-like (TLR) receptor genetic variants have been implicated in bacterial vaginosis (BV). We determined whether TLR variants are associated with fastidious BV-associated microbes that are linked with infertility following pelvic inflammatory disease (PID). METHOD OF STUDY: Sneathia spp., Atopobium vaginae, BVAB1, and Ureaplasma urealyticum were measured in 250 women from the PID Evaluation and Clinical Health (PEACH) study. Relative risk (RR) and 95% confidence intervals (CI) were calculated adjusting for chlamydia and gonorrhea...
December 29, 2017: American Journal of Reproductive Immunology: AJRI
https://www.readbyqxmd.com/read/29285481/comparing-the-frequency-of-endometritis-in-unexplained-infertility-and-anovulatory-infertility
#16
Ataollah Ghahiri, Bahare Malekzadeh, Hatav Ghassemi Tehrani
Background: Acute pelvic inflammatory disease (PID) is a common reason for infertility. This study aimed to evaluate the frequency distribution of endometritis in women with unexplained infertility and comparison with frequency distribution of endometritis in anovulatory infertility to identify the importance of endometritis due to subacute PID evaluation in the case of infertility. Materials and Methods: This case-control study was done on 100 women with unexplained infertility and ovulatory infertility who referred to Shahid Beheshti clinic in 2013 in Isfahan, Iran...
2017: Advanced Biomedical Research
https://www.readbyqxmd.com/read/29279357/successful-outcome-following-allogeneic-hematopoietic-stem-cell-transplantation-in-adults-with-primary-immunodeficiency
#17
Thomas A Fox, Ronjon Chakraverty, Siobhan Burns, Benjamin Carpenter, Kirsty Thomson, David Lowe, Adele Fielding, Karl Peggs, Panagiotis Kottaridis, Benjamin Uttenthal, Venetia Bigley, Matthew Buckland, Victoria Grandage, Shari Denovan, Sarah Grace, Julia Dahlstrom, Sarita Workman, Andrew Symes, Stephen Mackinnon, Rachael Hough, Emma Morris
INTRODUCTION: The primary immunodeficiencies (PID), rare inherited diseases characterised by severe dysfunction of immunity have been successfully treated by allogeneic hematopoietic stem cell transplantation (Allo-HSCT) in childhood. Controversy exists regarding optimal timing and use of Allo-HSCT in adults, due to lack of experience and previous poor outcomes. MATERIALS AND METHODS: 29 consecutive adult patients, with a mean age at transplant of 24 years (range 17-50) underwent Allo-HSCT...
December 26, 2017: Blood
https://www.readbyqxmd.com/read/29274877/comparisons-of-the-therapeutic-effects-of-three-different-routes-of-bone-marrow-mesenchymal-stem-cell-transplantation-in-cerebral-ischemic-rats
#18
Hong-Lian Zhang, Xu-Fang Xie, Ying-Qiong Xiong, Shi-Min Liu, Guo-Zhu Hu, Wen-Feng Cao, Xiao-Mu Wu
Bone marrow mesenchymal stem cells (BMSCs) are mainly administered via three routes: intra-arterial, intravenous and intracerebral. It has been reported that BMSC administration via each route ameliorates the functional deficits after cerebral ischemia. However, there have been no comparisons of the therapeutic benefits of BMSC administration through different delivery routes. In this study, we injected BMSCs into a rat model of transient middle cerebral artery occlusion (MCAO) through the intra-arterial, intravenous, or intracerebral route at day 7 after MCAO...
December 21, 2017: Brain Research
https://www.readbyqxmd.com/read/29249107/-common-immunodeficiency-variable-in-adults
#19
Patricia María O'Farrill-Romanillos, Diana Andrea Herrera-Sánchez, Cecilia Hernández-Fernández, Eunice Giselle López-Rocha
Primary immunodeficiencies (PIDs) are low-incidence diseases caused by defects in genes involved in the development, maintenance, and regulation of the immune system. Common variable immunodeficiency (CVID) is the most common symptomatic immunodeficiency of adulthood. It has an approximate prevalence of 1 in 25 000-50 000 in the general population, with a delay in diagnosis between 6-7 years. The clinical manifestations of CVID constitute six main categories: infections, pulmonary complications, granulomatous or polyclonal lymphocytic disease, autoimmunity, gastrointestinal diseases and malignancy Most patients must have at least one of the following clinical manifestations (infection, autoimmunity, lymphoproliferation)...
October 2017: Revista Alergia Mexico: Organo Oficial de la Sociedad Mexicana de Alergia e Inmunología, A.C
https://www.readbyqxmd.com/read/29239678/the-effect-of-antibiotic-prophylaxis-for-acute-pelvic-inflammatory-disease-after-hysterosalpingography-a-retrospective-cohort-study
#20
Hao-Ming Li, Fung-Chang Sung, Shang-Chieh Li, Ying-Kai Huang, Yu Chang, Chi-Chang Chang, S Joseph Huang, Cheng-Li Lin, Chia-Hung Kao
AIMS: The concern about acute pelvic inflammatory disease (PID) after hysterosalpingography (HSG) has been raised since 1980. However, the effectiveness of prophylactic antibiotics remains unclear. This study investigated the effect of antibiotic prophylaxis in women undergoing HSG. METHODS: Women undergoing HSG between 2000 and 2012 were screened from Taiwan National Health Insurance Research Database for eligibility. The prophylactic cohort included patients using any antibiotics of 1st-generation cephalosporins, doxycycline, clindamycin, and metronidazole, within seven days before HSG (N = 3257)...
December 14, 2017: Current Medical Research and Opinion
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