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anti Mullerian hormone

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https://www.readbyqxmd.com/read/28212156/impact-of-very-low-anti-m%C3%A3-llerian-hormone-on-pregnancy-success
#1
Alberto Pacheco, María Cruz, Juan A García-Velasco
PURPOSE OF REVIEW: Biomarkers are useful tool to help clinicians to estimate the chances of pregnancy of an infertile couple prior to assisted reproductive treatment. One proposed candidate is anti-Müllerian hormone (AMH), but its role as a predictor of reproductive success, especially in patients with low or very low levels, is under discussion. This review highlights recent findings from literature regarding to reproductive outcome in women with very low levels of AMH. RECENT FINDINGS: Although there is a general agreement about the lower pregnancy rates of patients with very low levels of AMH compared with patients with normal AMH levels, the role of AMH as a predictor of success is still under discussion...
February 15, 2017: Current Opinion in Obstetrics & Gynecology
https://www.readbyqxmd.com/read/28208955/high-serum-estradiol-and-heavy-metals-responsible-for-human-spermiation-defect-a-pilot-study
#2
Manish Jain, Amanpreet Kaur Kalsi, Amita Srivastava, Yogendra Kumar Gupta, Ashutosh Halder
INTRODUCTION: Spermiation is a process of releasing sperm into the lumen of seminiferous tubules. Failure in releasing sperm into the lumen is designated as spermiation defect. Spermiation defect cases present as oligo-azoospermia or azoospermia despite normal gonadotropins and testicular histology/cytology. Human spermiation defect never got attention to investigate infertility practice. Most of the information on spermiation defect, so far is from animal experiments. We assume some cases of non-obstructive azoospermia with normal gonadotropins and testicular histology/cytology could be due to spermiation defect...
December 2016: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28208941/anti-mullerian-hormone-a-marker-of-ovarian-reserve-and-its-association-with-polycystic-ovarian-syndrome
#3
Anil Kumar Verma, Sarita Rajbhar, Jyoti Mishra, Mayank Gupta, Mratunjai Sharma, Geeta Deshmukh, Wahid Ali
INTRODUCTION: Anti-Mullerian Hormone (AMH) is a useful endocrine marker for assessing the ovarian reserve. AMH serum level reflects the number of follicles that have made the transition from the primordial pool into the growing follicle pool, and it is not controlled by gonadotropins. AIM: The present study was conducted to correlate serum AMH levels with Polycystic Ovarian Syndrome (PCOS) and type of treatment protocol. MATERIALS AND METHODS: Serum AMH levels were performed in the early follicular phase (on 2(nd) day of menstrual cycle) both in infertile females including PCOS and control women...
December 2016: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28203731/expression-analysis-of-growth-differentiation-factor-9-gdf9-gdf9-anti-m%C3%A3-llerian-hormone-amh-amh-and-aromatase-cyp19a1a-cyp19a1a-during-gonadal-differentiation-of-the-zebrafish-danio-rerio%C3%A2
#4
https://www.readbyqxmd.com/read/28197932/effect-of-gnrha-ovulation-trigger-dose-on-follicular-fluid-characteristics-and-granulosa-cell-gene-expression-profiles
#5
Thi Ngoc Lan Vuong, M T Ho, T Q Ha, M Brehm Jensen, C Yding Andersen, P Humaidan
PURPOSE: A recent dose-finding study showed no significant differences in number of mature oocytes, embryos and top-quality embryos when triptorelin doses of 0.2, 0.3 or 0.4 mg were used to trigger final oocyte maturation in oocyte donors co-treated with a gonadotropin-releasing hormone (GnRH) antagonist. This analysis investigated whether triptorelin dosing for triggering final oocyte maturation in oocyte donors induced differences in follicular fluid (FF) hormone levels and granulosa cell gene expression...
February 14, 2017: Journal of Assisted Reproduction and Genetics
https://www.readbyqxmd.com/read/28197641/m%C3%A3-llerian-inhibiting-substance-inhibits-an-ovarian-cancer-cell-line-via-%C3%AE-catenin-interacting-protein-deregulation-of-the-wnt-signal-pathway
#6
Sang Ho Park, Youn Jee Chung, Jae Yen Song, Sang Il Kim, David Pépin, David T MacLaughlin, Patricia K Donahoe, Jang Heub Kim
Müllerian inhibiting substance/anti-Müllerian hormone (MIS/AMH) has been suggested as a biotherapeutic agent in gynecological cancers that highly express the MIS/AMH type II receptors (MISRII/AMHRII) but the anticancer mechanisms by which MIS/AMH acts are not fully understood. Our experiments show that MIS/AMH inhibits ovarian cancer by deregulating the Wnt signal pathway via the β-catenin interacting protein (ICAT). MIS/AMH inhibition of ICAT by small interfering RNAs (siRNA) decreased ICAT driven ovarian cancer cell viability as measured by the methylthiazoltetrazolium assay, reversed cell cycle arrest and annexin V expression and diminished migration by scratch wound assay...
February 13, 2017: International Journal of Oncology
https://www.readbyqxmd.com/read/28175316/the-addition-of-anti-m%C3%A3-llerian-hormone-in-an-algorithm-for-individualized-hormone-dosage-did-not-improve-the-prediction-of-ovarian-response-a-randomized-controlled-trial
#7
Å Magnusson, L Nilsson, G Oleröd, A Thurin-Kjellberg, C Bergh
No abstract text is available yet for this article.
February 8, 2017: Human Reproduction
https://www.readbyqxmd.com/read/28163853/bilateral-cryptorchidism-a-rare-presentation-for-persistent-m%C3%A3-llerian-duct-syndrome
#8
Abdullah Al-Faris, Mosleh Jabari, Mohammed Al-Sayed, Hassan Al-Shehri
Persistent Müllerian duct syndrome (PMDS) is a rare, sex-limited, autosomal recessive disorder representing male pseudo-hermaphroditism. It is observed in males with the presence of female reproductive organs such as the uterus, cervix, and bilateral fallopian tubes along with normally developed male reproductive organs. It generally occurs during embryogenesis due to mutation in anti-Müllerian hormone (AMH) gene, i.e., AMH gene or AMH receptor (AMHR2) gene. The present case reports a male infant with inflammation in the right groin who was admitted to Security Forces Hospital in 2015...
December 2016: Electronic Physician
https://www.readbyqxmd.com/read/28161677/serum-anti-m%C3%A3-llerian-hormone-and-inhibin-b-as-potential-markers-for-progressive-central-precocious-puberty-in-girls
#9
Ting Chen, Haiying Wu, Rongrong Xie, Fengyun Wang, Xiuli Chen, Hui Sun, Linqi Chen
STUDY OBJECTIVE: To investigate the potential of serum anti-Müllerian hormone (AMH) and inhibin B (INHB) levels as markers for pubertal progression rate in girls with central precocious puberty (CPP). DESIGN, SETTING, AND PARTICIPANTS, INTERWENTIONS, AND MAIN OUTCOME MEASURES: A total of 148 girls were enrolled, including 65 girls with premature thelarche (PT) and 83 girls with CPP, grouped based on the results of Gonadotropin-releasing hormone (GnRH) stimulation tests. Girls with CPP underwent a six-month follow-up, and were further divided into two subgroups: progressive CPP (P-CPP) group (n=55) and slowly progressive CPP (SP-CPP) group (n=28)...
February 1, 2017: Journal of Pediatric and Adolescent Gynecology
https://www.readbyqxmd.com/read/28153992/anti-m%C3%A3-llerian-hormone-trajectories-are-associated-with-cardiovascular-disease-in-women-results-from-the-doetinchem-cohort-study
#10
Annelien C de Kat, W Monique Verschuren, Marinus J C Eijkemans, Frank J M Broekmans, Yvonne T van der Schouw
BACKGROUND: Earlier age at menopause is widely considered to be associated with an increased risk of cardiovascular disease. However, the underlying mechanisms of this relationship remain undetermined. Indications suggest that anti-Müllerian hormone (AMH), an ovarian reserve marker, plays a physiological role outside of the reproductive system. Therefore, we investigated whether longitudinal AMH decline trajectories are associated with an increased risk of cardiovascular disease (CVD) occurrence...
February 7, 2017: Circulation
https://www.readbyqxmd.com/read/28145651/serum-anti-m%C3%A3-llerian-hormone-levels-in-precocious-puberty-girls-according-to-stage-of-gnrh-agonist-treatment
#11
Hyo Kyoung Nam, Hye Ryun Kim, Young Jun Rhie, Kee Hyoung Lee
Few studies have investigated the long-term effects of gonadotropin-releasing hormone (GnRH) agonist treatment on the reproductive function of central precocious puberty (CPP) girls. In this cross-sectional study, we assessed the ovarian function by analyzing the serum anti-Müllerian hormone (AMH) levels of CPP girls. Our study included 505 CPP girls subdivided into 5 groups according to the GnRH agonist treatment stage: group A (before treatment, n = 98), group B (3 months after initiation, n = 103), group C (12 months after initiation, n = 101), group D (24 months after initiation, n = 101), and group E (6 months after discontinuation, n = 102)...
March 2017: Journal of Korean Medical Science
https://www.readbyqxmd.com/read/28143632/extracellular-like-matrices-and-leukaemia-inhibitory-factor-for-in-vitro-culture-of-human-primordial-follicles
#12
Assiel J Younis, Galit Lerer-Serfaty, Dana Stav, Bethsabee Sabbah, Tzippy Shochat, Gania Kessler-Icekson, Muayad A Zahalka, Michal Shachar-Goldenberg, Avi Ben-Haroush, Benjamin Fisch, Ronit Abir
The possibility of maturing human primordial follicles in vitro would assist fertility restoration without the danger of reseeding malignancies. Leukaemia inhibitory factor (LIF) and certain culture matrices may promote human follicular growth. The present study compared human primordial follicular growth on novel culture matrices, namely human recombinant vitronectin (hrVit), small intestine submucosa (SIS), alginate scaffolds and human recombinant virgin collagen bioengineered in tobacco plant lines (CollPlant)...
February 1, 2017: Reproduction, Fertility, and Development
https://www.readbyqxmd.com/read/28142151/novel-amh-and-amhr2-mutations-in-two-egyptian-families-with-persistent-m%C3%A3-llerian-duct-syndrome
#13
Inas Mazen, Mona El-Gammal, Ken McElreavey, Aya Elaidy, Mohamed S Abdel-Hamid
Anti-müllerian hormone (AMH) is produced by Sertoli cells and signals through 2 transmembrane receptors (AMHR), specific types I and II, leading to regression of müllerian ducts during fetal male sex differentiation. Mutations in AMH and AMHR2 lead to the persistence of müllerian ducts in males which is transmitted in a recessive pattern. Here, we report 2 Egyptian DSD (disorder of sex development) patients reared as males who presented with bilateral cryptorchidism and otherwise normal male external genitalia and who both had a 46,XY karyotype...
February 1, 2017: Sexual Development: Genetics, Molecular Biology, Evolution, Endocrinology, Embryology, and Pathology of Sex Determination and Differentiation
https://www.readbyqxmd.com/read/28137855/amh-mis-as-a-contraceptive-that-protects-the-ovarian-reserve-during-chemotherapy
#14
Motohiro Kano, Amanda E Sosulski, LiHua Zhang, Hatice D Saatcioglu, Dan Wang, Nicholas Nagykery, Mary E Sabatini, Guangping Gao, Patricia K Donahoe, David Pépin
The ovarian reserve represents the stock of quiescent primordial follicles in the ovary which is gradually depleted during a woman's reproductive lifespan, resulting in menopause. Müllerian inhibiting substance (MIS) (or anti-Müllerian hormone/AMH), which is produced by granulosa cells of growing follicles, has been proposed as a negative regulator of primordial follicle activation. Here we show that long-term parenteral administration of superphysiological doses of MIS, using either an adeno-associated virus serotype 9 (AAV9) gene therapy vector or recombinant protein, resulted in a complete arrest of folliculogenesis in mice...
January 30, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28137754/efficacy-and-safety-of-follitropin-alfa-lutropin-alfa-in-art-a-randomized-controlled-trial-in-poor-ovarian-responders
#15
P Humaidan, W Chin, D Rogoff, T D'Hooghe, S Longobardi, J Hubbard, J Schertz
STUDY QUESTION: How does the efficacy and safety of a fixed-ratio combination of recombinant human FSH plus recombinant human LH (follitropin alfa plus lutropin alfa; r-hFSH/r-hLH) compare with that of r-hFSH monotherapy for controlled ovarian stimulation (COS) in patients with poor ovarian response (POR)? SUMMARY ANSWER: The primary and secondary efficacy endpoints were comparable between treatment groups and the safety profile of both treatment regimens was favourable...
January 30, 2017: Human Reproduction
https://www.readbyqxmd.com/read/28135602/anti-m%C3%A3-llerian-hormone-levels-and-evolution-in-women-of-reproductive-age-with-breast-cancer-treated-with-chemotherapy
#16
REVIEW
T Fréour, P Barrière, D Masson
BACKGROUND: Long-term consequences of cancer treatments in young women, and especially fertility issues, are gaining attention as survival rates increase. Breast cancer is the most frequent malignancy in women of reproductive age. AIM: The purpose of this review is to describe serum anti-müllerian hormone (AMH) level at diagnosis and its evolution during and after chemotherapy in women of reproductive age treated for breast cancer. Second, the impact of taxanes on AMH, the association between AMH and amenorrhea, and the comparison of AMH with other hormonal markers of ovarian reserve were studied...
January 27, 2017: European Journal of Cancer
https://www.readbyqxmd.com/read/28134393/anti-m%C3%A3-llerian-hormone-levels-in-chinese-women-younger-than-30-years-and-30-years-or-older-and-correlated-biochemical-indices
#17
Jieping Zhu, Jun Wang, Yu Chen, Yuqin Ji, Miao Xiong
Importance: Anti-müllerian hormone (AMH) is considered an important marker of ovarian reserve; however, the exact function of AMH has yet to be determined. Objective: Our purpose was to investigate factors correlated with AMH levels in Chinese women. Evidence Acquisition: Healthy women were divided into 2 groups: aged younger than 30 years and 30 years or older. Anti-müllerian hormone levels and biochemical indices were compared between the groups...
January 2017: Obstetrical & Gynecological Survey
https://www.readbyqxmd.com/read/28132978/positive-correlations-of-age-and-parity-with-plasma-anti-m%C3%A3-llerian-hormone-concentrations-in-japanese-black-cows
#18
Motoya Koizumi, Hiroya Kadokawa
Anti-Müllerian hormone (AMH) is secreted from the preantral and small antral follicles. It regulates follicle development and inhibits follicular atresia. This study examined how age, parity, and time after parturition affect plasma AMH concentrations in Japanese Black cows. We measured plasma AMH concentrations in primiparous, secundiparous, and multiparous (third parity or higher) cows at four time points: day 2 (day 0 = parturition), day 8, 2 days before first postpartum ovulation (pre-1stOv), and 12 days after first ovulation (post-1stOV)...
January 27, 2017: Journal of Reproduction and Development
https://www.readbyqxmd.com/read/28132758/specific-ranges-of-anti-mullerian-hormone-and-antral-follicle-count-correlate-to-provide-a-prognostic-indicator-for-ivf-outcome
#19
K N Keane, V F Cruzat, S R Wagle, N G Chaudhary, P Newsholme, J L Yovich
Advanced female age correlates with reduced ovarian reserve (OR) and is the primary factor underlying the limitation of success rates in Assisted Reproductive Technology (ART). Currently, predicted ovarian response to gonadotrophin stimulation is determined using transvaginal ultrasound to measure antral follicle count (AFC), an indirect measure of OR. However, assessing the level of anti-Mullerian hormone (AMH) has more recently been shown to correlate with OR, and its application has been adopted widely. This retrospective study was designed to determine the relationship between novel ranges of AMH and AFC in patients undergoing ART...
January 26, 2017: Reproductive Biology
https://www.readbyqxmd.com/read/28130407/a-putative-role-for-anti-m%C3%A3-llerian-hormone-amh-in-optimising-ovarian-reserve-expenditure
#20
Michael W Pankhurst
The mammalian ovary has a finite supply of oocytes which are contained within primordial follicles where they are arrested in a dormant state. The number of primordial follicles in the ovary at puberty is highly variable between females of the same species. Females that enter puberty with a small ovarian reserve are at risk of a shorter reproductive lifespan, as their ovarian reserve is expected to be depleted faster. One of the roles of anti-Müllerian hormone (AMH) is to inhibit primordial follicle activation which slows the rate at which the ovarian reserve is depleted...
January 27, 2017: Journal of Endocrinology
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