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https://www.readbyqxmd.com/read/28538514/long-term-outcome-of-4-patients-with-transcobalamin-deficiency-caused-by-2-novel-tcn2-mutations
#1
Marwan Nashabat, Gustavo Maegawa, Peter H Nissen, Ebba Nexo, Hussain Al-Shamrani, Mohammed Al-Owain, Majid Alfadhel
Cobalamin (vitamin B12 [Cbl]) is an essential cofactor for many biochemical pathways. Transcobalamin (TC) is required to internalize Cbl into the cells through membrane receptor-mediated endocytosis. Cbl is then processed in the cytoplasm and mitochondria by complementation factors leading to its active metabolites; methylcobalamin and 5-deoxyadenosyl-cobalamin. Deficiency of TC results in an elevation in methylmalonic acid and homocysteine. Patients usually present with macrocytic anemia, pancytopenia, failure to thrive, gastrointestinal symptoms, and neurological dysfunction...
May 22, 2017: Journal of Pediatric Hematology/oncology
https://www.readbyqxmd.com/read/28537876/activation-of-perk-branch-of-er-stress-mediates-homocysteine-induced-bkca%C3%A2-channel-dysfunction-in-coronary-artery-via-foxo3a-dependent-regulation-of-atrogin-1
#2
Wen-Tao Sun, Xiang-Chong Wang, Shiu-Kwong Mak, Guo-Wei He, Xiao-Cheng Liu, Malcolm John Underwood, Qin Yang
The molecular mechanism of endoplasmic reticulum (ER) stress in vascular pathophysiology remains inadequately understood. We studied the role of ER stress in homocysteine-induced impairment of coronary dilator function, with uncovering the molecular basis of the effect of ER stress on smooth muscle large-conductance Ca2+-activated K+ (BKCa) channels. The vasodilatory function of BKCa channels was studied in a myograph using endothelium-denuded porcine small coronary arteries. Primary cultured porcine coronary artery smooth muscle cells were used for mRNA and protein measurements and current recording of BKCa channels...
May 9, 2017: Oncotarget
https://www.readbyqxmd.com/read/28533142/evaluation-of-plasma-sphingosine-1-phosphate-hepcidin-and-cardiovascular-damage-biomarkers-cardiac-troponin-i-and-homocysteine-in-rats-infected-with-brucellosis-and-vaccinated-rev-1-rb-51
#3
Kaveh Azimzadeh, Reza Nasrollahi Nargesabad, Nasim Vousooghi
Brucellosis is known as one of important zoonosis. Studying the histological and biochemical effects of the disease could help to increase our knowledge about it. The aim of the present study was to evaluate changes of plasma parameters after intraperitoneal injection of two species of Brucella (Brucella melitensis and Brucella abortus) and two vaccines (Rev-1, RB-51) in the rat. Forty male rats were divided into five groups (n = 8 in each group). Two groups received suspensions of Brucella abortus and Brucella melitensis and two other groups were injected intraperitoneally with two mentioned vaccines and the last group received only distilled water...
May 19, 2017: Microbial Pathogenesis
https://www.readbyqxmd.com/read/28533090/identification-of-ahcy-inhibitors-using-novel-high-throughput-mass-spectrometry
#4
Noriko Uchiyama, Douglas R Dougan, J David Lawson, Hitomi Kimura, Shin-Ichi Matsumoto, Yukiya Tanaka, Tomohiro Kawamoto
S-adenosylhomocysteine hydrolase (AHCY) catalyzes the reversible hydrolysis of S-adenosylhomocysteine (SAH) to adenosine and L-homocysteine. This enzyme is frequently overexpressed in many tumor types and is considered to be a validated anti-tumor target. In order to enable the development of small molecule AHCY inhibitors as targeted cancer therapeutics we developed an assay based on a RapidFire high-throughput mass spectrometry detection system, which allows the direct measurement of AHCY enzymatic activity...
May 19, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28531847/colorimetric-detection-of-biothiols-based-on-aggregation-of-chitosan-stabilized-silver-nanoparticles
#5
Somayeh Mohammadi, Gholamreza Khayatian
We have described a simple and reliable colorimetric method for the sensing of biothiols such as cysteine, homocysteine, and glutathione in biological samples. The selective binding of chitosan capped silver nanoparticles to biothiols induced aggregation of the chitosan-Ag NPs. But the other amino acids that do not have thiol group cannot aggregate the chitosan-Ag NPs. Aggregation of chitosan-Ag NPs has been confirmed with UV-vis absorption spectra, zeta potential and transmission electron microscopy images...
May 17, 2017: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
https://www.readbyqxmd.com/read/28531791/an-innovative-brioche-enriched-in-protein-and-energy-improves-the-nutritional-status-of-malnourished-nursing-home-residents-compared-to-oral-nutritional-supplement-and-usual-breakfast-farine-project
#6
Virginie Van Wymelbeke, Laurent Brondel, Francis Bon, Isabelle Martin-Pfitzenmeyer, Patrick Manckoundia
BACKGROUND & AIMS: To compare the effects of a 12-week nutritional intervention, in which an innovative protein-and-energy-enriched brioche, an oral nutritional supplement or a usual breakfast were eaten, on food intake and nutritional status in nursing home residents. DESIGN: Three-armed, multicentre, controlled trial. SETTING: Eight nursing homes in Burgundy, France. PARTICIPANTS: Sixty-eight malnourished participants aged between 70 and 99 years old...
October 2016: Clinical Nutrition ESPEN
https://www.readbyqxmd.com/read/28527647/correlation-between-plasma-homocysteine-levels-and-craving-in-alcohol-dependent-stabilized-patients
#7
Maurizio Coppola, Raffaella Mondola
BACKGROUND & AIMS: Homocysteine is a sulfur amino acid strictly related with alcohol consumption. In alcoholics, hyperhomocysteinemia can increase the risk of various alcohol-related disorders such as: brain atrophy, epileptic seizures during withdrawal, and mood disorders. OBJECTIVE: To evaluate the correlation among serum homocysteine concentrations, craving, hazardous and harmful patterns of alcohol consumption in patients stabilized for withdrawal symptoms. METHODS: Participants were adult outpatients accessed at the Addiction Treatment Unit...
May 6, 2017: Clinical Nutrition: Official Journal of the European Society of Parenteral and Enteral Nutrition
https://www.readbyqxmd.com/read/28526947/association-of-ulcerative-colitis-with-transcobalamin-ii-gene-polymorphisms-and-serum-homocysteine-vitamin-b12-and-folate-levels-in-chinese-patients
#8
Shuzi Zheng, Wei Yang, Chaoqun Wu, Liang Sun, Daopo Lin, Xiuqing Lin, Lijia Jiang, Ran Ding, Yi Jiang
It has been reported that abnormal elevation of homocysteine is quite prevalent in ulcerative colitis (UC) patients. We attempted to explore the relationship of UC with transcobalamin II (TCN2) gene polymorphisms and serum homocysteine, vitamin B12, and folate levels in Chinese patients. TCN2 (rs1801198, rs9606756) genotypes were detected by the improved multiple ligase detection reaction (iMLDR) technique in 527 UC patients and 574 controls. Moreover, 128 UC patients and 138 controls were randomly selected for the measurement of homocysteine, vitamin B12, and folate levels by enzymatic cycling assay or chemiluminescence immunoassay...
May 19, 2017: Immunogenetics
https://www.readbyqxmd.com/read/28524030/-preventive-effect-of-vitamin-b-supplementation-on-recurrent-stroke-a-meta-analysis
#9
Guining Dai, Hongzhen Du, Hongmin Wang, Yujia Wei, Ying Xie, Zengning Li
OBJECTIVE: To evaluate whether Vitamin B supplementation could prevent ischemic stroke recurrence. METHODS: Randomized controlled trials (RCTs) observing Vitamin B supplementation in patients with stroke was performed in databases including ScienceDirect, PubMed/Medline, China National Knowledge Infrastructure, Chinese Biomedical Data-Base, Wanfang Database, and VIP Chinese Science and Technology Journal Database to find related studies in English or Chinese published before August 2016...
May 2017: Zhonghua Wei Zhong Bing Ji Jiu Yi Xue
https://www.readbyqxmd.com/read/28523235/effects-of-levodopa-carbidopa-intestinal-gel-versus-oral-levodopa-carbidopa-on-b-vitamin-levels-and-neuropathy
#10
Sebastian Loens, Elena Chorbadzhieva, Alexandra Kleimann, Dirk Dressler, Christoph Schrader
OBJECTIVES: To determine the possible interactions between levodopa therapy and plasma levels of B vitamins in patients with advanced idiopathic Parkinson's disease (IPD) in the context of either oral levodopa therapy or levodopa/carbidopa intestinal gel (LCIG). Secondly, to determine the prevalence of neuropathy and its relation to plasma levels of B vitamins and homocysteine. METHODS: Medication doses, neurographies, and serum levels of pyridoxine, cobalamin, folate, and homocysteine of eight LCIG and 13 orally treated advanced IPD patients matched for age, Hoehn & Yahr stage, and UPRDS III were collected...
May 2017: Brain and Behavior
https://www.readbyqxmd.com/read/28515935/methotrexate-encephalopathy-two-cases-in-adult-cancer-patients-who-recovered-with-pathophysiologically-based-therapy
#11
Shodeinde A Coker, David A Pastel, Melissa C Davis, Elizabeth M Bengtson, Camilo E Fadul, Lionel D Lewis
BACKGROUND/OBJECTIVES: Neurotoxicity is a serious and sometimes fatal adverse effect that can occur following methotrexate treatment. We describe two adult patients with hematological malignancies with methotrexate encephalopathy who recovered with dextromethorphan therapy. RESULTS: Case 1: A 24-year-old male with acute lymphoblastic leukemia developed the acute onset of bilateral facial weakness and slurred speech after his first treatment with high-dose intravenous methotrexate...
2017: SAGE open medical case reports
https://www.readbyqxmd.com/read/28514598/the-communal-relation-of-mthfr-mtr-ace-gene-polymorphisms-and-hyperhomocysteinemia-as-conceivable-risk-of-coronary-artery-disease
#12
Rizwan Masud, Haider Zaigham Baqai
Homocysteine and its modulating genes have strongly emerged as novel biomarkers for coronary artery disease (CAD). In present study, we investigated whether polymorphisms in homocysteine pathway genes and the plasma levels of homocysteine, folate and vitamin B12, independently or in combination, are associated with CAD risk. A total of 504 participants were recruited (cases n = 254, controls n = 250, respectively). Tetra primer allele refractory mutation system (ARMS) PCR was used for resolving the genotypes of 5'10' methylenetetrahydrofolate reductase 'MTHFR' polymorphisms (rs1801133, rs1801131), 5' methyl tetrahydrofolate homocysteine methyltransferase 'MTR' polymorphism (rs1805087), paroxanse1 'PON1' polymorphism (rs662), and cystathionine beta synthase 'CBS' polymorphism (rs5742905)...
May 17, 2017: Applied Physiology, Nutrition, and Metabolism, Physiologie Appliquée, Nutrition et Métabolisme
https://www.readbyqxmd.com/read/28513237/t-cell-subsets-are-associated-with-serum-homocysteine-concentration-in-patients-with-essential-hypertension
#13
Huifeng Xu, Huan Zheng, Junling Huang, Yi Shen, Ming Luo
OBJECTIVE: To explore the association between serum homocysteine (Hcy) concentration and T-cell subsets from patients with essential hypertension. PATIENTS AND METHODS: A total of 218 essential hypertension patients were recruited, of which 170 were H-type essential hypertensive and 48 were non-H-type essential hypertensive. H-type essential hypertensive patients were divided into three groups by concentration of serum Hcy. The peripheral blood T-cell subsets (CD3(+)%, CD4(+)%, CD8(+) T%, CD4(+)/CD8(+)) and clinical features including age, sex, serum creatinine, uric acid, total cholesterol, triglycerides, low-density lipoprotein cholesterol, and high-density lipoprotein cholesterol were recorded and analyzed with T-cell subsets which were counted by fluorescence activated cytometry...
May 17, 2017: Clinical and Experimental Hypertension: CHE
https://www.readbyqxmd.com/read/28512574/crystallographic-and-saxs-studies-of-s-adenosyl-l-homocysteine-hydrolase-from-bradyrhizobium-elkanii
#14
Tomasz Manszewski, Kamil Szpotkowski, Mariusz Jaskolski
S-Adenosyl-l-homocysteine hydrolase (SAHase) from the symbiotic bacterium Bradyrhizobium elkanii (BeSAHase) was crystallized in four ligand complexes with (i) mixed adenosine (Ado) and cordycepin (Cord; 3'-deoxyadenosine), (ii) adenine (Ade), (iii) Ado and (iv) mixed 2'-deoxyadenosine (2'-dAdo) and Ade. The crystal structures were solved at resolutions of 1.84, 1.95, 1.95 and 1.54 Å, respectively. Only the Ade complex crystallized with a dimer in the asymmetric unit, while all of the other complexes formed a crystallographically independent tetrameric assembly...
May 1, 2017: IUCrJ
https://www.readbyqxmd.com/read/28511341/in-vivo-and-molecular-docking-studies-using-whole-extract-and-phytocompounds-of-aegle-marmelos-fruit-protective-effects-against-isoproterenol-induced-myocardial-infarction-in-rats
#15
Gadamsetty Saayi Krushna, Vutharadhi Leela Shivaranjani, Jolapuram Umamaheswari, Cheemanapalli Srinivasulu, Shaik Althaf Hussain, Mohammed Abdul Kareem, Vaddi Damodara Reddy, Daoud Ali, Kiran Bharat Lokhande, K Venkateswara Swamy, Lakshmi Devi Kodidhela
Myocardial infarction (MI) is a leading major health problem with increased morbidity and mortality worldwide. The present study investigates isoproterenol (ISO) induced MI and the beneficial role of Aegle marmelos fruit extract (AMFE) in rats. Our results indicated the significant augmentation of plasma nitric oxide (NOx) levels, C-reactive protein (CRP), homocysteine, apolipoprotein B (apo-B), cardiac tissue lipid peroxidation and liver 3-hydroxy-3 methyl glutaryl CoA (HMG-CoA) reductase activity in ISO treated rats (85mg/kg b...
May 12, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28507207/role-of-osteocytes-in-mediating-bone-mineralization-during-hyperhomocysteinemia
#16
Viji Vijayan, Sarika Gupta
Hyperhomocysteinemia (HHCY) is a risk factor for osteoporosis but whether HHCY affects bone mineralization or not is still ambiguous. Herein we evaluated whether homocysteine affects tissue mineral density (TMD) of cortical bone and if so the role of osteocytes. CD1 mice administered with homocysteine (5 mg/100 g body weight, i.p.) for 7, 15 and 30 days showed temporal changes in TMD and osteocyte lacunar density in femoral cortices. Short-term administration of homocysteine (day 7) increased osteocyte lacunar density and reduced TMD evidenced by microCT50 while prolonged administration of homocysteine (day 30) reinstated TMD and lacunar density to baseline values...
June 2017: Journal of Endocrinology
https://www.readbyqxmd.com/read/28507011/influence-of-diet-in-multiple-sclerosis-a-systematic-review
#17
REVIEW
M José Bagur, M Antonia Murcia, Antonia M Jiménez-Monreal, Josep A Tur, M Mar Bibiloni, Gonzalo L Alonso, Magdalena Martínez-Tomé
Nutrition is considered to be a possible factor in the pathogenesis of the neurological disease multiple sclerosis (MS). Nutrition intervention studies suggest that diet may be considered as a complementary treatment to control the progression of the disease; a systematic review of the literature on the influence of diet on MS was therefore conducted. The literature search was conducted by using Medlars Online International Literature (MEDLINE) via PubMed and Scopus. Forty-seven articles met the inclusion criteria...
May 2017: Advances in Nutrition
https://www.readbyqxmd.com/read/28505046/south-asians-why-are-they-at-a-higher-risk-for-cardiovascular-disease
#18
Anjly Jain, Rajeev Puri, Devaki R Nair
PURPOSE OF REVIEW: We comment on the high prevalence of cardiovascular disease (CVD) in South Asians (SA). The effect of various risk factors, for example biochemical, genetic, lifestyle, socioeconomic factors and psychosocial stress on CVD risk is discussed. RECENT FINDINGS: 'Prediabetes' is common in SA, but its relationship with coronary artery disease (CAD) is not significant unlike for the white population. At the same time, 'prediabetes' in SA is associated with an increased risk for cerebrovascular disease (CeVD)...
May 12, 2017: Current Opinion in Cardiology
https://www.readbyqxmd.com/read/28501214/capillary-electrophoresis-tandem-mass-spectrometry-determination-of-glutamic-acid-and-homocysteine-s-metabolites-potential-biomarkers-of-amyotrophic-lateral-sclerosis
#19
Zuzana Cieslarova, Fernando Silva Lopes, Claudimir Lucio do Lago, Marcondes Cavalcante França, Ana Valéria Colnaghi Simionato
Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease that affects both lower and upper motor neurons, leading to muscle atrophy, paralysis, and death caused by respiratory failure or infectious complications. Altered levels of homocysteine, cysteine, methionine, and glutamic acid have been observed in plasma of ALS patients. In this context, a method for determination of these potential biomarkers in plasma by capillary electrophoresis tandem mass spectrometry (CE-MS/MS) is proposed herein. Sample preparation was carefully investigated, since sulfur-containing amino acids may interact with plasma proteins...
August 1, 2017: Talanta
https://www.readbyqxmd.com/read/28501188/a-hemicyanine-based-colorimetric-and-ratiometric-fluorescent-probe-for-selective-detection-of-cysteine-and-bioimaging-in-living-cell
#20
Guotao Liu, Dan Liu, Xie Han, Xiaole Sheng, Zhiqiang Xu, Sheng Hua Liu, Lintao Zeng, Jun Yin
A new ratiometric fluorescent probe based on a hemicyanine dye was synthesized. Investigation on the response behavior towards amino acids showed that the probe had a capability of rapidly and selectively detecting cysteine over other biothiols such as glutathione and homocysteine with similar structure and reactivity, and it also displayed a high selectivity and rapid response. Moreover, the probe had good water solubility, which authorized it could be applied in fluorescent bioimaging. The laser confocal fluorescence images indicated that the probe could visualize the intracellular cysteine...
August 1, 2017: Talanta
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