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https://www.readbyqxmd.com/read/29330520/association-of-homocysteine-with-aysmptomatic-intracranial-and-extracranial-arterial-stenosis-in-hypertension-patients
#1
Yan Wang, Jin Zhang, Yuesheng Qian, Xiaofeng Tang, Huawei Ling, Kemin Chen, Yan Li, Pingjin Gao, Dingliang Zhu
Elevated plasma homocysteine (Hcy) is suggested as an independent risk factor for stroke. We aimed to investigate the association of Hcy concentration with intracranial atherosclerosis (ICAS) and extracranial AS (ECAS) in hypertensive patients without stroke in Chinese population and to explore modified effect of methylenetetrahydrofolate reductase (MTHFR) C677T on their relationship. The stenosis of intracranial and extracranial arteries were evaluated in a total of 929 subjects through computerized tomographic angiography (CTA) from aortic arch to the skull base...
January 12, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29329865/in-vitro-evaluation-of-dietary-compounds-to-reduce-mercury-bioavailability
#2
Carlos Jadán-Piedra, Dinoraz Vélez, Vicenta Devesa
Mercury in foods, in inorganic form [Hg(II)] or as methylmercury (CH3Hg), can have adverse effects. Its elimination from foods is not technologically viable. To reduce human exposure, possible alternatives might be based on reducing its intestinal absorption. This study evaluates the ability of 23 dietary components to reduce the amount of mercury that is absorbed and reaches the bloodstream (bioavailability). We determined their effect on uptake of mercury in Caco-2 cells, a model of intestinal epithelium, exposed to Hg(II) and CH3Hg standards and to swordfish bioaccessible fractions...
May 15, 2018: Food Chemistry
https://www.readbyqxmd.com/read/29329322/methylene-tetrahydrofolate-reductase-contributes-to-allergic-airway-disease
#3
Kenneth R Eyring, Brent S Pedersen, Kenneth N Maclean, Sally P Stabler, Ivana V Yang, David A Schwartz
RATIONALE: Environmental exposures strongly influence the development and progression of asthma. We have previously demonstrated that mice exposed to a diet enriched with methyl donors during vulnerable periods of fetal development can enhance the heritable risk of allergic airway disease through epigenetic changes. There is conflicting evidence on the role of folate (one of the primary methyl donors) in modifying allergic airway disease. OBJECTIVES: We hypothesized that blocking folate metabolism through the loss of methylene-tetrahydrofolate reductase (Mthfr) activity would reduce the allergic airway disease phenotype through epigenetic mechanisms...
2018: PloS One
https://www.readbyqxmd.com/read/29326089/associations-between-markers-of-oxidative-stress-skeletal-muscle-mass-and-function-and-to-the-influence-of-resistance-exercise-training-in-older-adults
#4
Ciriaco Carru, Mariasole Da Boit, Panagiotis Paliogiannis, Angelo Zinellu, Salvatore Sotgia, Rachael Sibson, Judith R Meakin, Richard M Aspden, Arduino A Mangoni, Stuart R Gray
BACKGROUND: Oxidative stress (OS) negatively affects skeletal muscle homeostasis in experimental models of ageing. However, little is known about the associations between circulating OS markers and parameters of muscle mass and function, and their responses to exercise training, in humans. METHODS: Maximal voluntary contraction (MVC, primary outcome) and isokinetic torque of the knee extensors at 30° s-1 (MIT), muscle cross-sectional area (MCSA) and quality (MQ, secondary outcomes), and plasma concentrations of malondialdehyde (MDA, pro-OS), homocysteine (HCY, pro-OS), taurine (TAU, anti-OS), and protein sulphydryl groups (PSH, anti-OS) were measured in 27 healthy older males and 23 females at baseline and after an 18-week resistance exercise program, with or without a nutritional intervention (fish oil vs...
January 8, 2018: Experimental Gerontology
https://www.readbyqxmd.com/read/29325799/elevated-circulating-homocysteine-and-high-sensitivity-c-reactive-protein-jointly-predicts-post-stroke-depression-among-chinese-patients-with-acute-ischemic-stroke
#5
Jieyun Yin, Chongke Zhong, Zhengbao Zhu, Xiaoqing Bu, Tan Xu, Libing Guo, Xuemei Wang, Jintao Zhang, Yong Cui, Dong Li, Jianhui Zhang, Zhong Ju, Chung-Shiuan Chen, Jing Chen, Yonghong Zhang, Jiang He
BACKGROUND: Homocysteine (HCY) and high sensitivity C reactive protein (hs-CRP) were suggested to be involved in post-stroke depression (PSD), which is a frequent mood disorder after stroke. However, the combined effect of HCY and hs-CRP on PSD remains unclear. METHODS: A total of 598 acute ischemic stroke patients from 7 of 26 centers participating in the China Antihypertensive Trial in Acute Ischemic Stroke with HCY or hs-CRP measurements were included in this analysis...
January 8, 2018: Clinica Chimica Acta; International Journal of Clinical Chemistry
https://www.readbyqxmd.com/read/29324973/associations-among-plasma-total-homocysteine-levels-circadian-blood-pressure-variation-and-endothelial-function-in-hypertension
#6
Kazushi Tsuda
No abstract text is available yet for this article.
January 9, 2018: American Journal of Hypertension
https://www.readbyqxmd.com/read/29324779/filling-gaps-in-bacterial-amino-acid-biosynthesis-pathways-with-high-throughput-genetics
#7
Morgan N Price, Grant M Zane, Jennifer V Kuehl, Ryan A Melnyk, Judy D Wall, Adam M Deutschbauer, Adam P Arkin
For many bacteria with sequenced genomes, we do not understand how they synthesize some amino acids. This makes it challenging to reconstruct their metabolism, and has led to speculation that bacteria might be cross-feeding amino acids. We studied heterotrophic bacteria from 10 different genera that grow without added amino acids even though an automated tool predicts that the bacteria have gaps in their amino acid synthesis pathways. Across these bacteria, there were 11 gaps in their amino acid biosynthesis pathways that we could not fill using current knowledge...
January 2018: PLoS Genetics
https://www.readbyqxmd.com/read/29323380/aldehyde-functionalized-metal-organic-frameworks-for-selective-sensing-of-homocysteine-over-cys-gsh-and-other-natural-amino-acids
#8
Jian Wang, Yanhong Liu, Min Jiang, Yang Li, Lingling Xia, Pengyan Wu
A novel aldehyde-functionalized porous metal-organic framework (MOF) material has been constructed that can act as the first example of MOF-implicated sensors for discriminating Hcy from natural amino acids and even thiol-related peptides (GSH) with high sensitivity (LOD = 40 nM). The sensing mechanism is also discussed.
January 11, 2018: Chemical Communications: Chem Comm
https://www.readbyqxmd.com/read/29322980/neurology-of-renal-disorders
#9
Pushpendra N Renjen, Dinesh Chaudhari, Gaurav Sagar, Sanjiv Jasuja
Chronic kidney disease (CKD) is a critical and rapidly growing global health problem. Neurological complications occur in almost all patients with severe CKD, potentially affecting all levels of the nervous system, from the central nervous system (CNS) through to the peripheral nervous system (PNS). Patients with CKD exhibit a high incidence of symptomatic and occult cerebrovascular diseases, associated tremendously high levels of inflammatory factors and homocysteine, as well as anemia, hypertension, and diabetes...
January 2018: Neurology India
https://www.readbyqxmd.com/read/29322314/cognitive-impairment-is-associated-with-elevated-serum-homocysteine-levels-among-older-adults
#10
Sunghee Kim, Bo Youl Choi, Jung Hyun Nam, Mi Kyung Kim, Dong Hoon Oh, Yoon Jung Yang
PURPOSE: The aim of this study was to examine the associations between the risk of cognitive impairment and the serum levels of folate, vitamin B12, and homocysteine (Hcy). METHODS: Subjects were persons aged 60-79 years who participated in the Yangpyeong Cohort study between 2011 and 2012. Cognitive impairment and normal subjects consisted of 100 pairs of old adults matched by age, sex, and education levels. Cognitive function was evaluated with the Korean version of the Mini-Mental State Examination for Dementia Screening (MMSE-DS)...
January 10, 2018: European Journal of Nutrition
https://www.readbyqxmd.com/read/29321517/genome-wide-association-study-of-homocysteine-in-african-americans-from-the-jackson-heart-study-the-multi-ethnic-study-of-atherosclerosis-and-the-coronary-artery-risk-in-young-adults-study
#11
Laura M Raffield, Jaclyn Ellis, Nels C Olson, Qing Duan, Jin Li, Peter Durda, Nathan Pankratz, Brendan J Keating, Christina L Wassel, Mary Cushman, James G Wilson, Myron D Gross, Russell P Tracy, Stephen S Rich, Alex P Reiner, Yun Li, Monte S Willis, Ethan M Lange, Leslie A Lange
Homocysteine (Hcy) is a heritable biomarker for CVD, peripheral artery disease, stroke, and dementia. Little is known about genetic associations with Hcy in individuals of African ancestry. We performed a genome-wide association study for Hcy in 4927 AAs from the Jackson Heart Study (JHS), the Multi-Ethnic Study of Atherosclerosis (MESA), and the Coronary Artery Risk in Young Adults (CARDIA) study. Analyses were stratified by sex and results were meta-analyzed within and across sex. In the sex-combined meta-analysis, we observed genome-wide significant evidence (p < 5...
January 10, 2018: Journal of Human Genetics
https://www.readbyqxmd.com/read/29321350/neuro-fuzzy-model-of-homocysteine-metabolism
#12
Shaik Mohammad Naushad, Akella Radha Rama Devi, Sriraman Nivetha, Ganapathy Lakshmitha, Alex Balraj Stanley, Tajamul Hussain, Vijay Kumar Kutala
In view of well-documented association of hyperhomocysteinaemia with a wide spectrum of diseases and higher incidence of vitamin deficiencies in Indians, we proposed a mathematical model to forecast the role of demographic and genetic variables in influencing homocysteinemetabolism and investigated the influence of life style modulations in controlling homocysteine levels. Total plasma homocysteine levels were measured in fasting samples using reverse phase HPLC. Multiple linear regression (MLR) and neuro-fuzzy models were developed...
December 2017: Journal of Genetics
https://www.readbyqxmd.com/read/29321173/an-autophagy-independent-role-for-atg41-in-sulfur-metabolism-during-zinc-deficiency
#13
Michael D Bucci, Erin Weisenhorn, Spencer Haws, Zhiyuan Yao, Ginelle Zimmerman, Molly Gannon, Janet Taggart, Traci Lee, Daniel J Klionsky, Jason Russell, Joshua Coon, David J Eide
The Zap1 transcription factor of Saccharomyces cerevisiae is a key regulator in the genomic responses to zinc deficiency. Among the genes regulated by Zap1 during zinc deficiency is the autophagy-related gene ATG41 Here, we report that Atg41 is required for growth in zinc-deficient conditions but not when zinc is abundant or when other metals are limiting. Consistent with a role for Atg41 in macroautophagy, we show that nutritional zinc deficiency induces autophagy and that mutation of ATG41 diminishes that response...
January 10, 2018: Genetics
https://www.readbyqxmd.com/read/29319158/effect-of-restriction-vegan-diet-s-on-muscle-mass-oxidative-status-and-myocytes-differentiation-a-pilot-study
#14
D Vanacore, G Messina, S Lama, G Bitti, P Ambrosio, G C Tenore, A Messina, V Monda, S Zappavigna, M Boccellino, E Novellino, M Monda, P Stiuso
This study was conceived to evaluate the effects of three different diets on body composition, metabolic parameters and serum oxidative status. We enrolled three groups of healthy men (omnivores, vegetarians and vegans) with similar age, weight and BMI and we observed a significant decrease in muscle mass index and lean body mass in vegan compared to vegetarian and omnivore groups, and higher serum homocysteine levels in vegetarians and vegans compared to omnivores. We studied whether serum from omnivore, vegetarian and vegan subjects affected oxidative stress, growth and differentiation of both cardiomyoblast cell line H9c2 and H-H9c2 (H9c2 treated with H2 O2 to induce oxidative damage)...
January 10, 2018: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/29319008/cardiovascular-risk-factors-in-noise-exposed-workers-in-china-small-area-study
#15
Xiaoyuan Wu, Daya Yang, Wendong Fan, Chunyue Fan, Guifu Wu
INTRODUCTION: The aim of the present study was to evaluate whether there are changes in cardiovascular risk factors among noise-exposed workers and to explore the possible mechanisms of a long-term noise exposure leading to cardiovascular disease and the sex differences of cardiovascular risk factors in this population. MATERIALS AND METHODS: Two hundred workers engaged in noise-related work, and a control group of 200 nonnoise-exposed workers hospitalized for occupational health examination were assigned into the study...
November 2017: Noise & Health
https://www.readbyqxmd.com/read/29318097/flavin-based-light-driven-fluorescent-probe-for-the-detection-of-antioxidant-amino-acids
#16
Kyeong-Im Hong, Seong Min Lee, Woo-Dong Jang
We have synthesized a flavin-N(5)-oxide derivative with a p-toluenesulfonyl (Ts-OF) group as a "turn-on" fluorescent probe for the detection of several antioxidant amino acids and biothiols. Oxidized flavin was synthesized by using dithiothreitol as the reducing agent. Ts-OF showed a light-driven fluorescence enhancement in the presence of several amino acids and biothiols such as histidine (His), methionine (Met), cysteine (Cys), glutathione (GSH), and homocysteine (Hcy). The 1H NMR study indicated the reductive elimination of the p-toluenesulfonyl group from Ts-OF in the presence of antioxidants and photo-irradiation...
January 2018: ChemistryOpen
https://www.readbyqxmd.com/read/29316941/homocysteine-folate-hs-c-reactive-protein-tumor-necrosis-factor-alpha-and-inflammatory-proteins-are-these-biomarkers-related-to-nutritional-status-and-cardiovascular-risk-in-childhood-onset-systemic-lupus-erythematosus
#17
Roberta Garcia Salomão, Luciana Martins de Carvalho, Clarice Izumi, Érika Silva Czernisz, José César Rosa, Sonir Roberto Rauber Antonini, Ana Carolina Bueno, Maria Olímpia Ribeiro do Vale Almada, Carolina de Almeida Coelho-Landell, Alceu Afonso Jordão, Virgínia Paes Leme Ferriani, Jacqueline Pontes Monteiro
BACKGROUND: Childhood-onset systemic lupus erythematosus (c-SLE) is a chronic autoimmune disease which increases cardiovascular risk factors (CRF) such as elevated homocysteine, TNF-α, and hs-C reactive protein. METHODS: We evaluated BMI, waist circumference (WC), 24-h recalls, SLEDAI-2 K, SLICC/ACR-DI, serum levels of homocysteine, folate, TNF-α, hs-C reactive protein, lipid profile, proteomic data, and duration of corticosteroid therapy in 19 c-SLE and 38 healthy volunteers...
January 9, 2018: Pediatric Rheumatology Online Journal
https://www.readbyqxmd.com/read/29314620/a-thiolactone-strategy-for-straightforward-synthesis-of-disulfide-linked-side-chain-to-tail-cyclic-peptides-featuring-a-n-terminal-modification-handle
#18
Dorien Van Lysebetten, Stefania Felissati, Eirini Antonatou, Lieselot Carrette, Pieter Espeel, Evelien Foquet, Filip Du Prez, Annemieke Madder
The development of straightforward and versatile peptide cyclisation methods is highly desired in order to meet the demand for more stable peptide based drugs. In this paper, a new method for the synthesis of side chain-to-tail cyclic peptides with simultaneous introduction of a N-terminal handle based on the introduction of a N-terminal thiolactone building block, is described. A primary amine liberates a homocysteine analogue from the thiolactone building block which further enables cyclisation of the peptide through disulfide bond formation with a C-terminal cysteamine...
January 4, 2018: Chembiochem: a European Journal of Chemical Biology
https://www.readbyqxmd.com/read/29310724/effect-of-long-term-nutraceutical-and-dietary-supplement-use-on-cognition-in-the-elderly-a-10-year-systematic-review-of-randomised-controlled-trials
#19
Nathan M D'Cunha, Ekavi N Georgousopoulou, Lakshika Dadigamuwage, Jane Kellett, Demosthenes B Panagiotakos, Jackson Thomas, Andrew J McKune, Duane D Mellor, Nenad Naumovski
Nutraceuticals have generated interest as a way to mitigate the cognitive decline in older adults. The aim of this systematic review was to determine the evidence for these claims from the scientific literature in randomised, double-blinded, controlled trials (duration: ≥1 year; participants: n≥100; age(mean): ≥65 years). Following Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines, we searched four electronic databases (PubMed, Scopus, CINAHL and Web of Science) and identified twenty-five studies published between the 15·June·2006 and 14·June·2016...
January 9, 2018: British Journal of Nutrition
https://www.readbyqxmd.com/read/29306994/association-between-maternal-and-infantile-markers-of-cobalamin-status-during-the-first-month-post-delivery
#20
Sümeyra Çoban, Ebru Yılmaz Keskin, Mahir İğde
OBJECTIVE: Exclusively breast-fed infants born to vitamin B12 (cobalamin, cbl)-deficient mothers can develop symptoms within a few months following delivery. The authors aimed to assess the relationship between maternal and infantile markers of cbl status. METHODS: In 240 full-term infants (age, 2-30 d) admitted to Samsun Maternity and Child Health Hospital and their mothers, complete blood count testing and serum cbl, folate and plasma total homocysteine (tHcy) measurements were performed...
January 6, 2018: Indian Journal of Pediatrics
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