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Swetha Sangomla, Mohd Aslam Saifi, Amit Khurana, Chandraiah Godugu
Doxorubicin (DOX) is one of the most commonly used anticancer drugs but its use has been limited due to constraints of cardiotoxic side effects. The precise mechanism underlying cardiotoxicity is not yet fully understood but oxidative stress has been found to be a primary mechanism behind this. In addition, DOX induced cardiotoxicity also shows involvement of proinflammatory cytokines such as IL-6 and TNF-α. Since oxidative stress plays major role in DOX induced cardiotoxicity, different antioxidants have been tried to prevent cardiotoxicity of DOX...
May 2018: Journal of Trace Elements in Medicine and Biology
Kenta Kuroda, M Ochi, H S Suzuki, M Hirayama, M Nakayama, R Noguchi, C Bareille, S Akebi, S Kunisada, T Muro, M D Watson, H Kitazawa, Y Haga, T K Kim, M Hoesch, S Shin, R Arita, Takeshi Kondo
Experimental determinations of bulk band topology in the solid states have been so far restricted to only indirect investigation through the probing of surface states predicted by electronic structure calculations. We here present an alternative approach to determine the band topology by means of bulk-sensitive soft x-ray angle-resolved photoemission spectroscopy. We investigate the bulk electronic structures of the series materials, Ce monopnictides (CeP, CeAs, CeSb, and CeBi). By performing a paradigmatic study of the band structures as a function of their spin-orbit coupling, we draw the topological phase diagram and unambiguously reveal the topological phase transition from a trivial to a nontrivial regime in going from CeP to CeBi induced by the band inversion...
February 23, 2018: Physical Review Letters
Vanessa Koehlé-Divo, Carole Cossu-Leguille, Sandrine Pain-Devin, Cécile Simonin, Carole Bertrand, Bénédicte Sohm, Catherine Mouneyrac, Simon Devin, Laure Giambérini
The rapid development of nanotechnology and the increased use of nanomaterials in products used in everyday life have raised the question of the potential release of nanoparticles into the aquatic environment. Their fate and effects in natural ecosystems are not currently well understood but harmful effects of nanoparticles have been demonstrated at low concentrations on some freshwater and marine species. Cerium dioxide nanoparticles (CeO2 NPs) are produced in large quantities and used in products in many different fields, such as automotives or optics...
February 27, 2018: Aquatic Toxicology
Perrine Chaurand, Wei Liu, Daniel Borschneck, Clément Levard, Mélanie Auffan, Emmanuel Paul, Blanche Collin, Isabelle Kieffer, Sophie Lanone, Jérôme Rose, Jeanne Perrin
In this methodological study, we demonstrated the relevance of 3D imaging performed at various scales for the ex vivo detection and location of cerium oxide nanomaterials (CeO2 -NMs) in mouse lung. X-ray micro-computed tomography (micro-CT) with a voxel size from 14 µm to 1 µm (micro-CT) was combined with X-ray nano-computed tomography with a voxel size of 63 nm (nano-CT). An optimized protocol was proposed to facilitate the sample preparation, to minimize the experimental artifacts and to optimize the contrast of soft tissues exposed to metal-based nanomaterials (NMs)...
March 13, 2018: Scientific Reports
A A Markus, P Krystek, P C Tromp, J R Parsons, E W M Roex, P de Voogt, R W P M Laane
We investigated the occurrence of metal-based nanoparticles in a natural system, the river Dommel in the Netherlands. The river itself is well-studied as far as hydrology and water quality is concerned, easily accessible and contains one major wastewater treatment plant discharging onto this river. We sampled water from various locations along the river and collected samples of influent, effluent and sewage sludge from the wastewater treatment plant. The sampling campaign was carried out in June 2015 and these samples were analysed for seven elements using high-resolution inductively coupled plasma mass spectrometry (HR-ICP-MS), ultrafiltration with a sequence of mesh sizes and scanning electron microscopy (SEM)...
March 9, 2018: Science of the Total Environment
Shih-Ming Tsai, Edith Duran-Robles, Tyler Goshia, Maria Mesina, Carlos Garcia, Julia Young, Angelo Sibal, Meng-Hsuen Chiu, Wei-Chun Chin
Nanotoxicity studies associated with various nanoparticles (NPs) have attracted intense research interest due to the broader applications of nanoparticles in our daily lives. The exposure of nanoparticles can lead to hypersecretion and accumulation of airway mucus which are closely associated with many respiratory diseases. Titanium dioxide (TiO2 ), one of the PM10 components, is a major NP that is widely utilized in many commercial products. Our previous study established the connection between induced airway mucus secretion and TiO2 NPs...
March 8, 2018: Science of the Total Environment
Ruben Palacio, Sebastian Torres, Sébastien Royer, Anne Sophie Mamede, Diana López, Diana Hernández
Ceria supported copper oxide catalysts were produced by a deposition-precipitation method, at a high copper loading (up to >25 wt%). These materials demonstrated excellent properties for glycerol selective conversion to lactic acid, with a conversion reaching up to 87% with a selectivity to lactic acid of 74% (8 h reaction, 220 °C, under N2 pressure). These catalysts also exhibited high stability upon 5 successive reaction cycles. The formation of a crystalline CuO phase was demonstrated in the nanocomposites at a high Cu loading, with elongated shaped particles formed on the cerium oxide surface...
March 7, 2018: Dalton Transactions: An International Journal of Inorganic Chemistry
Shenqiang Zou, Xiaofang Zhu, Lirong Zhang, Fan Guo, Miaomiao Zhang, Youwen Tan, Aihua Gong, Zhengzou Fang, Huixiang Ju, Chaoyang Wu, Fengyi Du
Cerium oxide nanoparticles recently have received extensive attention in biomedical applications due to their excellent anti-oxidation performance. In this study, a simple, mild, and green approach was developed to synthesize cerium-doped carbonaceous nanoparticles (Ce-doped CNPs) using bio-mineralization of bull serum albumin (BSA) as precursor. The resultant Ce-doped CNPs exhibited uniform and ultrasmall morphology with an average size of 14.7 nm. XPS and FTIR results revealed the presence of hydrophilic group on the surface of Ce-doped CNPs, which resulted in excellent dispersity in water...
March 6, 2018: Nanoscale Research Letters
Laura Falchi, Grazia Galleri, Gian Mario Dore, Maria Teresa Zedda, Salvatore Pau, Luisa Bogliolo, Federica Ariu, Alessandra Pinna, Stefano Nieddu, Plinio Innocenzi, Sergio Ledda
BACKGROUND: Cerium oxide nanoparticles (CeO2 NPs) are able to store and release oxygen, conferring them scavenger activity against oxidative stress. However, their effects in reproductive systems are not yet well understood. The aim of the study was to investigate the effects of exposure of refrigerated ram semen to CeO2 NPs for 96 h on the main structural and kinematic parameters of spermatozoa. METHODS: The ejaculates of 5 Sarda rams were collected, pooled and diluted in a soybean lecithin extender...
March 6, 2018: Reproductive Biology and Endocrinology: RB&E
Seyed Jalal Hosseinimehr
: Background: Radiotherapy is an important protocol in the treatment of cancers, but radioresistance of cancerous cells is a challenge in cancer treatment. OBJECTIVE: The aim of this study was to evaluate the radiosensitizing effect of cerium oxide nanoparticles (CNPs) on human promyelocytic leukemia cells (HL-60). METHOD: HL-60 cells were treated with CNPs at different concentrations (10-100 µg/ml) and exposed to ionizing radiation (IR). The genotoxicity effects of CNPs or/and IR were assessed by micronuclei assay in HL-60 cells...
March 6, 2018: Pharmaceutical Nanotechnology
Abhishek Sadhu, Ilika Ghosh, Yuji Moriyasu, Anita Mukherjee, Maumita Bandyopadhyay
The effect of cerium oxide nanoparticle (CeNP) in plants has elicited substantial controversy. While some investigators have reported that CeNP possesses antioxidant properties, others observed CeNP to induce reactive oxygen species (ROS). In spite of considerable research carried out on the effects of CeNP in metazoans, fundamental studies that can unveil its intracellular consequences linking ROS production, autophagy and DNA damage are lacking in plants. To elucidate the impact of CeNP within plant cells, tobacco BY-2 cells were treated with 10, 50 and 250 µg ml-1 CeNP (Ce10, Ce50 and Ce250), for 24 h...
February 28, 2018: Mutagenesis
F Ayca Ozdemir Olgun, Ayşem Üzer, Birsen Demirata Ozturk, Reşat Apak
Antioxidant activity (AOA) assays using nanotechnology are recently developed utilizing nanoparticles of transition metal oxides, especially nanoceria that can switch between trivalent and tetravalent oxidation states of cerium. Cerium oxide nanoparticles (CeO-NPs) may act as both an oxidant and an antioxidant, depending on the preparation method and particle size. A novel colorimetric sensor for AOA assay is proposed with the use of poly(acrylic acid) sodium salt (PAANa)-coated CeO-NPs. PAANa-coated CeO-NPs oxidized tetramethyl benzidine (TMB), a peroxidase substrate, in a slightly acidic solution at pH 4...
May 15, 2018: Talanta
Maren Sack-Zschauer, Elif Karaman-Aplak, Claudia Wyrich, Soumen Das, Thies Schubert, Hajo Meyer, Christoph Janiak, Sudipta Seal, Wilhelm Stahl, Peter Brenneisen
The biomedical application of cerium oxide nanoparticles (nanoceria) is a focal point of research for a few years. The biochemical effects of nanoceria depend on various factors including particle size, oxidation state of cerium, oxygen vacancies on the surface, use of dispersants or coatings, pH and cell type. Due to their autocatalytic redox-activity, these particles are considered to act as a specific anti-cancer tool with less side effects on healthy cells and tissues, as the particles kill tumor cells, while protecting healthy cells from oxidative damage...
December 1, 2017: Journal of Biomedical Nanotechnology
Xiqian Wang, Chenxi Liu, Yuying Jiang, Chiming Wang, Tianyu Wang, Ming Bai, Jianzhuang Jiang
The modulation of solid-state supramolecular assemblies at room temperature is still challenging even though it potentially has very important application prospects. Herein, based on the possibility of overall conformational changes in double-decker phthalocyanine, the room temperature chiral reorganization of solid-state assemblies was investigated. LS (Langmuir-Schaefer) films of achiral double-decker cerium phthalocyanine were fabricated via air-water interfacial assembly and the dependence of supramolecular chirality on the assembly of the achiral double-decker molecules was identified...
February 27, 2018: Physical Chemistry Chemical Physics: PCCP
Yuriko Nakano, Asumi Ochiai, Keisuke Kawamoto, Ayaka Takeda, Kenta Ichiyoshi, Toshihiko Ohnuki, Michael F Hochella, Satoshi Utsunomiya
To understand the competing effects of the components in extracellular substances (ES), polymeric substances (PS) and low-molecular-weight small substances (SS) <1 kDa derived from microorganisms, on the colloidal stability of cerium dioxide nanoparticles (CeNPs), we investigated their adsorption to sparingly soluble CeNPs at room temperature at pH 6.0. The ES was extracted from the fungus S. cerevisiae. The polypeptides and phosphates in all components preferentially adsorbed onto the CeNPs. The zeta potentials of ES + CeNPs, PS + CeNPs, and SS + CeNPs overlapped on the plot of PS itself, indicating the surface charge of the polymeric substances controls the zeta potentials...
February 26, 2018: Scientific Reports
Rui Fang, Shaohang Wu, Weitao Chen, Zonghao Liu, Shasha Zhang, Rui Chen, Youfeng Yue, Lin-Long Deng, Yibing Cheng, Liyuan Han, Wei Chen
Stability issues and high material cost constitute the biggest obstacles of perovskite solar cell (PVSC), hampering its sustainable development. Herein, we demonstrate that, after suitable surface modification, the low-cost cerium oxide (CeOx) nanocrystals can be well dispersed in both polar and non-polar solvents and easily processed into high quality electron transport layers (ETLs). The inverted PVSC with the configuration of "NiMgLiO/MAPbI3/[6,6]-phenyl-C61-butyric acid methyl ester (PCBM)/CeOx" has achieved a high efficiency up to 18...
February 26, 2018: ACS Nano
Dingsheng Wang, Pingyu Xin, Jia Li, Yu Xiong, Xi Wu, Juncai Dong, Wenxing Chen, Yu Wang, Lin Gu, Jun Luo, Hongpan Rong, Chen Chen, Qing Peng, Yadong Li
Supported metal catalysts are one of the foundations of modern chemical industry. The active species in such catalysts are always elusive to identify, and in the meanwhile large quantities of inert species can cause significant waste. Herein, using a stoichiometrically precise synthetic method, we prepare atomically dispersed palladium-cerium oxide (Pd1/CeO2) and hexapalladium cluster-cerium oxide (Pd6/CeO2), as confirmed by spherical-aberration-corrected transmission electron microscopy and X-ray absorption fine structure spectroscopy...
February 21, 2018: Angewandte Chemie
Thummavichai Kunyapat, Fang Xu, Nigle Neate, Nannan Wang, Adolfo De Sanctis, Saverio Russo, Shaowei Zhang, Yongda Xia, Yanqiu Zhu
Cerium (Ce)-doped tungsten oxide nanostructures were synthesised using a simple solvothermal method from cerium chloride salt (CeCl3 ·7H2 O) and tungsten hexachloride (WCl6 ) precursors. The as-prepared samples were thoroughly characterised using electron microscopies, X-ray diffraction (XRD), X-ray photoelectron spectroscopy (XPS) and Raman spectroscopy. The electrochromic performance of different samples was evaluated using a custom-built UV-VIS spectrometer and an electrochemistry technique. The results showed that the as-prepared samples underwent morphological evolution with the increase in the Ce/W molar ratio, from long, thin and bundled nanowires, through shorter and thicker nanowires to mixed nanowire bundles and nanoparticle agglomerates...
February 21, 2018: Nanoscale
Daniela Schwotzer, Monika Niehof, Dirk Schaudien, Heiko Kock, Tanja Hansen, Clemens Dasenbrock, Otto Creutzenberg
BACKGROUND: Understanding the molecular mechanisms of nanomaterial interacting with cellular systems is important for appropriate risk assessment. The identification of early biomarkers for potential (sub-)chronic effects of nanoparticles provides a promising approach towards cost-intensive and animal consuming long-term studies. As part of a 90-day inhalation toxicity study with CeO2 NM-212 and BaSO4 NM-220 the present investigations on gene expression and immunohistochemistry should reveal details on underlying mechanisms of pulmonary effects...
February 20, 2018: Journal of Nanobiotechnology
Prabha Nini Gupta, Subair M Kunju, Baiju Rajan, A George Koshy, Sunitha Vishwanathan, Preeti Sara George, Praveen Velappan
OBJECTIVES: To compare the clinical presentation, clinical profile and survival of two groups of endomyocardial fibrosis patients. METHODS: The study was a prospective cohort study, or a prospective case series, comparing all consecutive echocardiographically proven patients with endomyocardial fibrosis seen in Medical College Trivandrum with the patients seen in Medical College Hospital, Alappuzha(Alleppey) (or TD Medical College). In all patients the clinical details like age, sex, type of endomyocardial fibrosis, the presence of anaemia, eosinophilia, neutrophilia and type of rhythm(Sinus or atrial fibrillation) etc were compared by both simple X2 and by Kaplan Meier survival curves...
January 2018: Indian Heart Journal
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