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leprosy and arthritis

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https://www.readbyqxmd.com/read/29075476/phylogeographic-and-phylogenetic-analysis-for-tripterygium-species-delimitation
#1
Baowei Ma, Tianyuan Hu, Pei Li, Qingjun Yuan, Zhaoshou Lin, Yuhe Tu, Jia Li, Xianan Zhang, Xiaoyi Wu, Xiujuan Wang, Luqi Huang, Wei Gao
Tripterygium wilfordii (Celastraceae) is a traditional Chinese medicine; and the dried root and rhizome constitute the main officinal parts. Tripterygium wilfordii has been identified as a potential candidate for the treatment of systemic lupus erythematosus, rheumatoid arthritis, nephritis, asthma, leprosy, and cancer. The phylogenetic relationships within the Tripterygium genus are ambiguous; thus, our aim is to clarify the relationships within this genus using phylogeographic and phylogenetic analyses. Here, we first sequenced three plastid DNA regions (i...
October 2017: Ecology and Evolution
https://www.readbyqxmd.com/read/29028793/clinico-pathological-features-of-erythema-nodosum-leprosum-a-case-control-study-at-alert-hospital-ethiopia
#2
Edessa Negera, Stephen L Walker, Selfu Girma, Shimelis N Doni, Degafe Tsegaye, Saba M Lambert, Munir H Idriss, Yohanis Tsegay, Hazel M Dockrell, Abraham Aseffa, Diana N Lockwood
BACKGROUND: Leprosy reactions are a significant cause of morbidity in leprosy population. Erythema nodosum leprosum (ENL) is an immunological complication affecting approximately 50% of patients with lepromatous leprosy (LL) and 10% of borderline lepromatous (BL) leprosy. ENL is associated with clinical features such as skin lesions, neuritis, arthritis, dactylitis, eye inflammation, osteitis, orchitis, lymphadenitis and nephritis. ENL is treated mainly with corticosteroids and corticosteroids are often required for extended periods of time which may lead to serious adverse effects...
October 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28962889/a-new-clerodane-furano-diterpene-glycoside-from-tinospora-cordifolia-triggers-autophagy-and-apoptosis-in-hct-116-colon-cancer-cells
#3
Neha Sharma, Ashok Kumar, P R Sharma, Arem Qayum, Shashank K Singh, Prabhu Dutt, Satya Paul, Vivek Gupta, M K Verma, N K Satti, R Vishwakarma
ETHNOPHARMACOLOGICAL RELEVANCE: Tinospora cordifolia is a miraculous ayurvedic herb used in the treatment of innumerable diseases such as diabetes, gonorrhea, secondary syphilis, anaemia, rheumatoid arthritis, dermatological diseases, cancer, gout, jaundice, asthma, leprosy, in the treatment of bone fractures, liver & intestinal disorders, purifies the blood, gives new life to the whole body; (rejuvenating herb) and many more. Recent studies have revealed the anticancer potential of this plant but not much work has been done on the anticancer chemical constituents actually responsible for its amazing anticancer effects...
September 27, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/28647179/euphorbia-neriifolia-l-review-on-botany-ethnomedicinal-uses-phytochemistry-and-biological-activities
#4
REVIEW
Prashant Y Mali, Shital S Panchal
The present review is intended to provide information on botany, ethnomedicinal uses, phytochemistry and biological activities of various parts of Euphorbia neriifolia (E. neriifolia). E. neriifolia has several ethnomedicinal uses. The latex of E. neriifolia is used as laxative, purgative, rubefacient, carminative and expectorant as well as in treatment of whooping cough, gonorrhoea, leprosy, asthma, dyspepsia, jaundice, enlargement of the spleen, tumours, stone in the bladder, abdominal troubles and leucoderma...
May 2017: Asian Pacific Journal of Tropical Medicine
https://www.readbyqxmd.com/read/28592626/longitudinal-ip-10-serum-levels-are-associated-with-the-course-of-disease-activity-and-remission-in-patients-with-rheumatoid-arthritis
#5
Anouk van Hooij, Debbie M Boeters, Elisa M Tjon Kon Fat, Susan J F van den Eeden, Paul L A M Corstjens, Annette H M van der Helm-van Mil, Annemieke Geluk
Although rheumatoid arthritis (RA) is a chronic, persistent autoimmune disease, 10 to 15% of RA patients achieve sustained disease-modifying antirheumatic drug (DMARD)-free remission over time. The biological mechanisms underlying the resolution of persistent inflammation in RA are still unidentified, and there is a lack of prognostic markers. It is well established that increased serum levels of gamma interferon-induced protein 10 (IP-10) are associated with (acute) increased inflammatory responses (e.g., in leprosy)...
August 2017: Clinical and Vaccine Immunology: CVI
https://www.readbyqxmd.com/read/27959965/functional-analyses-of-the-crohn-s-disease-risk-gene-lacc1
#6
Ghazaleh Assadi, Liselotte Vesterlund, Ferdinando Bonfiglio, Luca Mazzurana, Lina Cordeddu, Danika Schepis, Jenny Mjösberg, Sabrina Ruhrmann, Alessia Fabbri, Vladana Vukojevic, Piergiorgio Percipalle, Florian A Salomons, Jurga Laurencikiene, Leif Törkvist, Jonas Halfvarson, Mauro D'Amato
BACKGROUND: Genetic variation in the Laccase (multicopper oxidoreductase) domain-containing 1 (LACC1) gene has been shown to affect the risk of Crohn's disease, leprosy and, more recently, ulcerative colitis and juvenile idiopathic arthritis. LACC1 function appears to promote fatty-acid oxidation, with concomitant inflammasome activation, reactive oxygen species production, and anti-bacterial responses in macrophages. We sought to contribute to elucidating LACC1 biological function by extensive characterization of its expression in human tissues and cells, and through preliminary analyses of the regulatory mechanisms driving such expression...
2016: PloS One
https://www.readbyqxmd.com/read/27859670/leprosy-reactions-in-postelimination-stage-the-bangladesh-experience
#7
M R Mowla, S Ara, A F M Mizanur Rahman, S P Tripura, S Paul
BACKGROUND: Leprosy reactions are immunologically mediated conditions and a major cause of disability before, during and after multidrug therapy (MDT). Little data have been published on the epidemiology of leprosy reactions in Bangladesh. OBJECTIVES: To describe the pattern and prevalence of leprosy reactions in the postelimination stage. METHODS: A descriptive retrospective cross-sectional study was carried out in Chittagong Medical College Hospital using the registered records of patients in the period between 2004 and 2013...
April 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/27693176/leprosy-simulating-systemic-sclerosis-a-case-report
#8
Bruna Burko Rocha Chu, Giorgina Falcão Brandão Côrtes Gobbo, Rafaela Copês, Glênio Gutjahr, Erick Cavalcanti Cossa, Eduardo Dos Santos Paiva
No abstract text is available yet for this article.
September 17, 2016: Revista Brasileira de Reumatologia
https://www.readbyqxmd.com/read/27516029/the-value-of-histopathological-diagnosis-in-the-elderly-patients-with-granulomatous-dermatoses-case-series
#9
Mihail Alexandru Badea, Corneliu Florin Buicu, Anca Ileana Sin, Ovidiu Simion Cotoi, Iudita Maria Badea, Andreea Luciana Chiotoroiu, Silviu Horia Morariu
Granulomatous inflammations are a particular type of chronic septic or aseptic inflammation, in which infectious or non-infectious agents are difficult to eliminate by the immune system. These are type IV hypersensitivity reactions mediated by pre-sensitized T-lymphocytes cells CD4+ and CD8+ lymphocytes. Disorders included in this category are: tuberculosis, leprosy, syphilis, sarcoidosis, type I diabetes, multiple sclerosis, Crohn's disease and rheumatoid arthritis. At cutaneous level, this pattern of granulomatous reaction is characterized by a chronic inflammation with formation of granulomas consisting of a variable number of histiocytes, multinucleated giant cells and lymphocytes...
2016: Romanian Journal of Morphology and Embryology, Revue Roumaine de Morphologie et Embryologie
https://www.readbyqxmd.com/read/27478939/c13orf31-famin-is-a-central-regulator-of-immunometabolic-function
#10
M Zaeem Cader, Katharina Boroviak, Qifeng Zhang, Ghazaleh Assadi, Sarah L Kempster, Gavin W Sewell, Svetlana Saveljeva, Jonathan W Ashcroft, Simon Clare, Subhankar Mukhopadhyay, Karen P Brown, Markus Tschurtschenthaler, Tim Raine, Brendan Doe, Edwin R Chilvers, Jules L Griffin, Nicole C Kaneider, R Andres Floto, Mauro D'Amato, Allan Bradley, Michael J O Wakelam, Gordon Dougan, Arthur Kaser
Single-nucleotide variations in C13orf31 (LACC1) that encode p.C284R and p.I254V in a protein of unknown function (called 'FAMIN' here) are associated with increased risk for systemic juvenile idiopathic arthritis, leprosy and Crohn's disease. Here we set out to identify the biological mechanism affected by these coding variations. FAMIN formed a complex with fatty acid synthase (FASN) on peroxisomes and promoted flux through de novo lipogenesis to concomitantly drive high levels of fatty-acid oxidation (FAO) and glycolysis and, consequently, ATP regeneration...
September 2016: Nature Immunology
https://www.readbyqxmd.com/read/27464771/leprosy-masquerading-as-systemic-rheumatic-diseases
#11
REVIEW
Hala El-Gendy, Rasmia M El-Gohary, Kyrillus S Shohdy, Gaafar Ragab
Rheumatologic manifestations not only are encountered in leprosy but also can be the first and even the sole presenting manifestation. The hallmark of leprosy is skin and peripheral nerve affection; however, it can affect a wide range of other organs, with the joints being the commonest. We have searched PubMed with the key words leprosy, arthritis, vasculitis, rheumatic diseases, and autoantibodies in a proper combination. Relevant studies were retrieved from scanning of their abstracts. The relevant references provided in these articles were also selected and reviewed...
August 2016: Journal of Clinical Rheumatology: Practical Reports on Rheumatic & Musculoskeletal Diseases
https://www.readbyqxmd.com/read/27395832/hansens-chronic-polyarthritis-in-a-child
#12
Ananya Das, Rakesh Mondal, Kaushani Chatterjee, Dona Banerjee
BACKGROUND: Musculoskeletal manifestations of leprosy are often underdiagnosed and under-reported. CASE CHARACTERISTICS: An 11-year old girl with leprosy presented with deforming symmetric polyarthritis with raised inflammatory parameters and erosion on imaging. OBSERVATION: The patient was diagnosed to have Hansens chronic polyarthritis and treatment started with non-steroidal anti inflammatory drugs and methotrexate. MESSAGE: Hansen chronic polyarthritis is a rare differential of juvenile chronic arthritis in children...
August 8, 2016: Indian Pediatrics
https://www.readbyqxmd.com/read/27098602/lacc1-polymorphisms-in-inflammatory-bowel-disease-and-juvenile-idiopathic-arthritis
#13
G Assadi, R Saleh, F Hadizadeh, L Vesterlund, F Bonfiglio, J Halfvarson, L Törkvist, A S Eriksson, H E Harris, E Sundberg, M D'Amato
The function of the Laccase domain-containing 1 (LACC1) gene is unknown, but genetic variation at this locus has been reported to consistently affect the risk of Crohn's disease (CD) and leprosy. Recently, a LACC1 missense mutation was found in patients suffering from monogenic forms of CD, but also systemic juvenile idiopathic arthritis. We tested the hypothesis that LACC1 single nucleotide polymorphisms (SNPs), in addition to CD, are associated with juvenile idiopathic arthritis (JIA, non-systemic), and another major form of inflammatory bowel disease, ulcerative colitis (UC)...
2016: Genes and Immunity
https://www.readbyqxmd.com/read/27008827/-some-case-reports-which-suggest-correlation-between-biologics-and-leprosy-mini-symposium-on-problems-on-leprosy
#14
Yutaka Ishida
Biologics are relatively new drugs developed through modern monoclonal antibody techniques and became more familiar to some disease treatments such as Rheumatoid arthritis, psoriasis, ankylosing spondylitis, ulcerative colitis, malignant lymphoma, SLE and lupus nephritis. Some case reports shows development of leprosy during/after biolo- gics treatment and success treatment of ENL with biologics. Collection of reports was done through web search by using document retrieval engine such as Pub-med and ProQuest...
January 2016: Japanese Journal of Leprosy: Official Organ of the Japanese Leprosy Association
https://www.readbyqxmd.com/read/26964436/bullous-erythema-nodosum-leprosum-masquerading-as-systemic-onset-juvenile-idiopathic-arthritis-a-case-report
#15
Swetalina Pradhan, Bibhu Prasad Nayak, Tanmay Padhi, Madhusmita Sethy
No abstract text is available yet for this article.
December 2015: Leprosy Review
https://www.readbyqxmd.com/read/26805555/integrative-analyses-of-leprosy-susceptibility-genes-indicate-a-common-autoimmune-profile
#16
Deng-Feng Zhang, Dong Wang, Yu-Ye Li, Yong-Gang Yao
BACKGROUND: Leprosy is an ancient chronic infection in the skin and peripheral nerves caused by Mycobacterium leprae. The development of leprosy depends on genetic background and the immune status of the host. However, there is no systematic view focusing on the biological pathways, interaction networks and overall expression pattern of leprosy-related immune and genetic factors. OBJECTIVES: To identify the hub genes in the center of leprosy genetic network and to provide an insight into immune and genetic factors contributing to leprosy...
April 2016: Journal of Dermatological Science
https://www.readbyqxmd.com/read/26535712/nlrp3-rs35829419-polymorphism-is-associated-with-increased-susceptibility-to-multiple-diseases-in-humans
#17
Q Zhang, H W Fan, J Z Zhang, Y M Wang, H J Xing
Using a meta-analysis framework, we investigated the association between the NLRP3 rs35829419 polymorphism and increased susceptibility to diverse diseases in humans. Relevant published studies were identified through a comprehensive and systematic electronic search, using the following scientific literature databases: Science Citation Index, the Cochrane Library, PubMed, Embase, CINAHL, Current Contents Index, Chinese Biomedical, the Chinese Journal Full-Text, and the Weipu Journal. Statistical analysis of data extracted from the selected high quality studies was performed using the Version 12...
October 30, 2015: Genetics and Molecular Research: GMR
https://www.readbyqxmd.com/read/26351858/enlist-1-an-international-multi-centre-cross-sectional-study-of-the-clinical-features-of-erythema-nodosum-leprosum
#18
MULTICENTER STUDY
Stephen L Walker, Marivic Balagon, Joydeepa Darlong, Shimelis N Doni, Deanna A Hagge, Vikas Halwai, Annamma John, Saba M Lambert, Armi Maghanoy, Jose A C Nery, Kapil D Neupane, Peter G Nicholls, Vivek V Pai, Pawan Parajuli, Anna M Sales, Euzenir Sarno, Mahesh Shah, Digafe Tsegaye, Diana N J Lockwood
Erythema nodosum leprosum (ENL) is a severe multisystem immune mediated complication of borderline lepromatous leprosy and lepromatous leprosy. ENL is associated with skin lesions, neuritis, arthritis, dactylitis, eye inflammation, osteitis, orchitis, lymphadenitis and nephritis. The treatment of ENL requires immunosuppression, which is often required for prolonged periods of time and may lead to serious adverse effects. ENL and its treatment is associated with increased mortality and economic hardship. Improved, evidence-based treatments for ENL are needed; however, defining the severity of ENL and outcome measures for treatment studies is difficult because of the multiple organ systems involved...
2015: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/26250118/evaluation-of-rheumatoid-factor-and-anti-citrullinated-peptide-antibodies-in-relation-to-rheumatological-manifestations-in-patients-with-leprosy-from-southern-brazil
#19
COMPARATIVE STUDY
Carla Fontoura Dionello, Shirley Ramos Rosa Utiyama, Sebastião Cézar Radominski, Ewalda Stahlke, Servio Tulio Stinghen, Iara Jose de Messias-Reason
BACKGROUND: Leprosy patients may present several osteoarticular complaints, which require further evaluation of inflammatory diseases, such as rheumatoid arthritis (RA). Therefore, an adequate clinical assessment in addition to testing for rheumatoid factors (RF) and anticyclic citrullinated peptide antibodies (anti-CCP), can be useful in order to establish the correct diagnosis. METHOD: In this study, the relation of RF and anti-CCP with rheumatological manifestations was evaluated in 97 leprosy patients from Southern Brazil...
October 2016: International Journal of Rheumatic Diseases
https://www.readbyqxmd.com/read/26151758/genomic-modulators-of-gene-expression-in-human-neutrophils
#20
Vivek Naranbhai, Benjamin P Fairfax, Seiko Makino, Peter Humburg, Daniel Wong, Esther Ng, Adrian V S Hill, Julian C Knight
Neutrophils form the most abundant leukocyte subset and are central to many disease processes. Technical challenges in transcriptomic profiling have prohibited genomic approaches to date. Here we map expression quantitative trait loci (eQTL) in peripheral blood CD16+ neutrophils from 101 healthy European adults. We identify cis-eQTL for 3281 neutrophil-expressed genes including many implicated in neutrophil function, with 450 of these not previously observed in myeloid or lymphoid cells. Paired comparison with monocyte eQTL demonstrates nuanced conditioning of genetic regulation of gene expression by cellular context, which relates to cell-type-specific DNA methylation and histone modifications...
July 7, 2015: Nature Communications
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