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https://www.readbyqxmd.com/read/29244847/cognitive-failures-in-late-adulthood-the-role-of-age-social-context-and-depressive-symptoms
#1
Paul Kenneth Hitchcott, Maria Chiara Fastame, Dalila Langiu, Maria Pietronilla Penna
The incidence of self-reported cognitive failures among older adults may be an index of successful cognitive aging. However, self-reported cognitive failures are biased by variation in depressive symptomatology. This study examined age-related and socio-cultural context effects on cognitive failures while controlling for depressive symptoms. Both overall and specific factors of cognitive failures were determined. A further goal was to investigate the relationship between working memory and cognitive efficiency measures and cognitive failures...
2017: PloS One
https://www.readbyqxmd.com/read/29244531/effects-of-natural-peptides-from-food-proteins-on-angiotensin-converting-enzyme-activity-and-hypertension
#2
Melanie Martin, Andreas Deussen
Cardiovascular diseases are the leading cause of death. The underlying pathophysiology is largely contributed by an overactivation of the renin-angiotensin-aldosterone-system (RAAS). Herein, angiotensin II (AngII) is a key mediator not only in blood pressure control and vascular tone regulation, but also involved in inflammation, endothelial dysfunction, atherosclerosis, hypertension and congestive heart failure. Since more than three decades suppression of AngII generation by inhibition of the angiotensin-converting enzyme (ACE) or blockade of the AngII-receptor has shown clinical benefit by reducing hypertension, atherosclerosis and other inflammation-associated cardiovascular diseases...
December 15, 2017: Critical Reviews in Food Science and Nutrition
https://www.readbyqxmd.com/read/29244218/person-specific-contribution-of-neuropathologies-to-cognitive-loss-in-old-age
#3
Patricia A Boyle, Lei Yu, Robert S Wilson, Sue E Leurgans, Julie A Schneider, David A Bennett
OBJECTIVE: Mixed neuropathologies are the most common cause of dementia at the population level, but how different neuropathologies contribute to cognitive decline at the individual level remains unknown. We quantified the contribution of nine neuropathologies to cognitive loss at an individual level. METHODS: Participants (n=1,079) came from 2 longitudinal clinical-pathologic studies of aging. All completed 2+ cognitive evaluations (maximum = 22), died and underwent neuropathologic examinations to identify Alzheimer's disease (AD), other neurodegenerative diseases, and vascular pathologies...
December 15, 2017: Annals of Neurology
https://www.readbyqxmd.com/read/29243580/coumarins-as-promising-scaffold-for-the-treatment-of-age-related-diseases-an-overview-of-the-last-five-years
#4
Giovanna Lucia Delogu, Maria Joao Matos
Degenerative diseases are becoming increasingly prevalent with the aging of the human population. The twentieth century witnessed a significant demographic change in the industrialized world that is currently followed by a similar shift of life expectancy to upper age ranges in Asia, Africa, and Middle and South America. A rising tide of chronic age-dependent diseases will soon present serious challenges for these countries. Age-related diseases are commonly seen in older patients. More than 40% of adults 60 and older have a combination of risk factors known as metabolic syndrome, which increases the risk for developing degenerative disorders, and certain cancers...
December 14, 2017: Current Topics in Medicinal Chemistry
https://www.readbyqxmd.com/read/29243450/pathogenesis-of-age-related-macular-degeneration-dialogue-between-autophagy-and-inflammasomes
#5
Niko Kivinen, Ali Koskela, Anu Kauppinen, Kai Kaarniranta
Age-related macular degeneration is a condition affecting central vision, and is the leading cause of blindness and visual impairment in the western countries. For a long time, inflammation has been associated with the pathogenesis of the condition, and according to current knowledge, inflammation in the retinal pigment epithelial cells (RPE) results from an impairment of intracellular cleansing systems. In combination with the degeneration of RPE cells, this eventually leads to the destruction of light-sensing cells...
2017: Duodecim; Lääketieteellinen Aikakauskirja
https://www.readbyqxmd.com/read/29243257/differential-impact-of-tongue-exercise-on-intrinsic-lingual-muscles
#6
Miranda J Cullins, Brittany N Krekeler, Nadine P Connor
OBJECTIVES/HYPOTHESIS: Aging is associated with muscle fiber hypotrophy and decreased percentages of rapidly contracting myosin heavy chain (MyHC) type IIb muscle fibers. Tongue exercise programs used to treat dysphagia target age-related decline in tongue muscle function, but the impact of exercise on the intrinsic tongue muscles is unknown. We hypothesized that exercise would induce muscle fiber hypertrophy and increase the percentage of MyHC IIa fibers in the intrinsic tongue. STUDY DESIGN: Animal model...
December 15, 2017: Laryngoscope
https://www.readbyqxmd.com/read/29242921/analysis-of-the-association-between-physical-activity-and-age-related-macular-degeneration
#7
Myra B McGuinness, Julie A Simpson, Robert P Finger
No abstract text is available yet for this article.
December 14, 2017: JAMA Ophthalmology
https://www.readbyqxmd.com/read/29242918/a-nationwide-cohort-study-on-the-association-between-past-physical-activity-and-neovascular-age-related-macular-degeneration-in-an-east-asian-population
#8
Tyler Hyungtaek Rim, Hong Kyu Kim, Ji Won Kim, Jihei Sara Lee, Dong Wook Kim, Sung Soo Kim
Importance: It has been suggested that physical activity (PA) is associated with reduced risk for early age-related macular degeneration (AMD). Systematic evaluation has been examining the association between lifestyle and neovascular AMD in an East Asian population, with a particular focus on past vigorous PA. Objective: To investigate the association between neovascular AMD and past PA, particularly a history of vigorous exercise, in the overall study population and among 2 a priori-defined subgroups...
December 14, 2017: JAMA Ophthalmology
https://www.readbyqxmd.com/read/29242907/skin-intrinsic-fluorescence-and-age-related-macular-degeneration-the-beaver-dam-eye-study
#9
Ronald Klein, Kristine E Lee, John D Maynard, Stacy M Meuer, Ronald E Gangnon, Barbara E K Klein
Purpose: To determine if skin intrinsic fluorescence (SIF), a noninvasive measure of advanced glycation endproducts and oxidative stress in skin is associated with AMD. Methods: SIF was measured with the SCOUT DS skin fluorescence spectrometer in a cross-sectional cohort study of 969 persons aged 68 to 102 years from the 1181 who participated in the 25-year follow-up examination in the Beaver Dam Eye Study (BDES) in 2014 to 2016. The SCOUT DS skin fluorescence spectrometer uses five light-emitting diodes, centered at 375 nm to 456 nm...
December 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/29242543/the-twilight-of-immunity-emerging-concepts-in-aging-of-the-immune-system
#10
REVIEW
Janko Nikolich-Žugich
Immunosenescence is a series of age-related changes that affect the immune system and, with time, lead to increased vulnerability to infectious diseases. This Review addresses recent developments in the understanding of age-related changes that affect key components of immunity, including the effect of aging on cells of the (mostly adaptive) immune system, on soluble molecules that guide the maintenance and function of the immune system and on lymphoid organs that coordinate both the maintenance of lymphocytes and the initiation of immune responses...
January 2018: Nature Immunology
https://www.readbyqxmd.com/read/29242473/morphological-variation-of-the-long-tailed-reed-finch-i-donacospiza-i-i-albifrons-i-vieillot-1817-aves-thraupidae
#11
Leonardo Esteves Lopes
The Long-tailed Reed Finch Donacospiza albifrons of south-central South America is patchily distributed in a variety of open habitats, usually near water. I present a detailed study of morphological variation based on 141 specimens, describing its plumage sequence and presenting notes on its molt and breeding. The Long-tailed Reed Finch shows no sexual dichromatism, but males average longer-winged than females. The species shows three distinct age-related plumages, which are redescribed here. It also shows marked individual variation in plumage and size, also showing marked plumage variation due to feather wear...
October 4, 2017: Zootaxa
https://www.readbyqxmd.com/read/29241834/efficacy-and-safety-of-oral-and-transdermal-opioid-analgesics-for-musculoskeletal-pain-in-older-adults-a-systematic-review-of-randomized-placebo-controlled-trials
#12
REVIEW
Rodrigo Z Megale, Leticia A Deveza, Fiona M Blyth, Vasi Naganathan, Paulo H Ferreira, Andrew J McLachlan, Manuela L Ferreira
This systematic review with meta-analysis was performed to evaluate the efficacy and safety of using opioid analgesics in older adults with musculoskeletal pain. We searched Cochrane Library, MEDLINE, EMBASE, Web of Science, AMED, CINAHL and LILACS for randomized controlled trial with mean population age of 60 years or older, comparing the efficacy and safety of opioid analgesics with placebo for musculoskeletal pain conditions. Reviewers extracted data, assessed risk of bias and evaluated the quality of evidence using the GRADE approach...
December 11, 2017: Journal of Pain: Official Journal of the American Pain Society
https://www.readbyqxmd.com/read/29241653/synaptic-adaptations-to-chronic-ethanol-intake-in-male-rhesus-monkey-dorsal-striatum-depend-on-age-of-drinking-onset
#13
Verginia C Cuzon Carlson, Kathleen A Grant, David M Lovinger
One in 12 adults suffer with alcohol use disorder (AUD). Studies suggest the younger the age in which alcohol consumption begins the higher the probability of being diagnosed with AUD. Binge/excessive alcohol drinking involves a transition from flexible to inflexible behavior likely involving the dorsal striatum (caudate and putamen nuclei). A major focus of this study was to examine the effect of age of drinking onset on subsequent chronic, voluntary ethanol intake and dorsal striatal circuitry. Data from rhesus monkeys (n = 45) that started drinking as adolescents, young adults or mature adults confirms an age-related risk for heavy drinking...
December 12, 2017: Neuropharmacology
https://www.readbyqxmd.com/read/29241617/effectiveness-of-a-lifestyle-intervention-led-by-female-community-health-volunteers-versus-usual-care-in-blood-pressure-reduction-cobin-an-open-label-cluster-randomised-trial
#14
Dinesh Neupane, Craig S McLachlan, Shiva Raj Mishra, Michael Hecht Olsen, Henry B Perry, Arjun Karki, Per Kallestrup
INTRODUCTION: Elevated blood pressure greatly contributes to cardiovascular deaths in low-income and middle-income countries. We aimed to investigate the effectiveness of a population-level intervention led by existing community health workers in reducing the burden of hypertension in a low-income population. METHODS: We did a community-based, open-label, two-group, cluster-randomised controlled trial in Nepal. Using computer-generated codes, we randomly assigned (1:1) 14 clusters to a lifestyle intervention led by female community health volunteers (FCHVs) or usual care (control group)...
January 2018: Lancet Global Health
https://www.readbyqxmd.com/read/29240820/age-related-nomograms-for-antral-follicle-count-and-anti-mullerian-hormone-for-subfertile-chinese-women-in-singapore
#15
See Ling Loy, Yin Bun Cheung, Marielle Valerie Fortier, Chiou Li Ong, Heng Hao Tan, Sadhana Nadarajah, Jerry Kok Yen Chan, Veronique Viardot-Foucault
BACKGROUND: Antral follicle count (AFC) and anti-Mullerian hormone (AMH) are known as the most reliable markers of a woman's ovarian reserve and are related to age. There is currently no specific local age-related centile charts for AFC and AMH. Therefore, we aim to examine the relationship between AFC and AMH with age and construct age-related nomograms among a subfertile Asian population. METHODS: This is a study involving Chinese women who had their AFC and AMH measured as part of their subfertility screening from December 2010 until November 2014 in KK Women's and Children's Hospital, Singapore...
2017: PloS One
https://www.readbyqxmd.com/read/29240257/altered-expression-of-telomere-associated-genes-in-leukocytes-among-brca1-and-brca2-carriers
#16
Hiromi Tanaka, Elizabeth A Phipps, Ting Wei, Xi Wu, Chirayu Goswami, Yunlong Liu, George W Sledge, Lida Mina, Brittney-Shea Herbert
Telomere dysfunction resulting from telomere shortening and deregulation of shelterin components has been linked to the pathogenesis of age-related disorders, including cancer. Recent evidence suggests that BRCA1/2 (BRCA1 and BRCA2) tumor suppressor gene products play an important role in telomere maintenance. Although telomere shortening has been reported in BRCA1/2 carriers, the direct effects of BRCA1/2 haploinsufficiency on telomere maintenance and predisposition to cancer development are not completely understood...
December 14, 2017: Molecular Carcinogenesis
https://www.readbyqxmd.com/read/29240038/prevalence-of-hypertension-htn-and-cardiovascular-risk-factors-in-a-hospitalized-pediatric-hemophilia-population
#17
Warren Alperstein, Fernando F Corrales-Medina, Leonardo Tamariz, Ana M Palacio, Joanna A Davis
Improved life expectancy in hemophilia has led to a greater interest in age-related disorders. Hypertension (HTN) as well as cardiovascular disease have been increasingly reported in hemophilic adults but there is currently very limited data in the pediatric population. We conducted a cross-sectional study using data from the 2012 National Health Cost and Utilization Project database to determine the prevalence of HTN and associated cardiovascular risk factors in a hospitalized pediatric hemophilia population, between the ages of 0 to 21 years, in comparison with the general pediatric population...
December 12, 2017: Journal of Pediatric Hematology/oncology
https://www.readbyqxmd.com/read/29239712/multiparametric-mr-imaging-of-age-related-changes-in-healthy-thigh-muscles
#18
Min A Yoon, Suk-Joo Hong, Min Cheol Ku, Chang Ho Kang, Kyung-Sik Ahn, Baek Hyun Kim
Purpose To use multiparametric magnetic resonance (MR) imaging to assess for and establish age-related differences in healthy thigh muscles. Materials and Methods Ninety-five subjects (47 men, 48 women; median age, 47 years) with healthy body mass index were grouped according to age: 30-39 years (n = 25), 40-49 years (n = 25), 50-59 years (n = 25), and 60-69 years (n = 20). Multiparametric MR imaging (intravoxel incoherent motion diffusion-weighted, diffusion-tensor, multiecho Dixon, and dynamic contrast material-enhanced MR imaging) was performed at 3...
December 14, 2017: Radiology
https://www.readbyqxmd.com/read/29239656/attentional-effects-of-hand-proximity-occur-later-in-older-adults-evidence-from-event-related-potentials
#19
Catherine L Reed, Summer N Clay, Abigail O Kramer, David S Leland, Alan A Hartley
Research with young adults has shown hand proximity biases attention both early (by the time stimuli are categorized as relevant for action) and later, selectively for goal-relevant-stimuli. We examined age-related changes in this multisensory integration of vision and proprioception by comparing behavior and event-related potentials (ERPs) between younger and older adults. In a visual detection task, the hand was placed near or kept far from target and nontarget stimuli matched for frequency and visual features...
December 2017: Psychology and Aging
https://www.readbyqxmd.com/read/29239655/music-to-my-ears-age-related-decline-in-musical-and-facial-emotion-recognition
#20
Ryan Sutcliffe, Peter G Rendell, Julie D Henry, Phoebe E Bailey, Ted Ruffman
We investigated young-old differences in emotion recognition using music and face stimuli and tested explanatory hypotheses regarding older adults' typically worse emotion recognition. In Experiment 1, young and older adults labeled emotions in an established set of faces, and in classical piano stimuli that we pilot-tested on other young and older adults. Older adults were worse at detecting anger, sadness, fear, and happiness in music. Performance on the music and face emotion tasks was not correlated for either age group...
December 2017: Psychology and Aging
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