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Medication Induced Kidney Injury

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https://www.readbyqxmd.com/read/27903075/australian-taipan-oxyuranus-spp-envenoming-clinical-effects-and-potential-benefits-of-early-antivenom-therapy-australian-snakebite-project-asp-25
#1
Christopher I Johnston, Nicole M Ryan, Margaret A O'Leary, Simon G A Brown, Geoffrey K Isbister
CONTEXT: Taipans (Oxyuranus spp.) are medically important venomous snakes from Australia and Papua New Guinea. The objective of this study was to describe taipan envenoming in Australian and its response to antivenom. METHODS: Confirmed taipan bites were recruited from the Australian Snakebite Project. Data were collected prospectively on all snakebites, including patient demographics, bite circumstances, clinical effects, laboratory results, complications and treatment...
November 30, 2016: Clinical Toxicology
https://www.readbyqxmd.com/read/27882736/crystalline-nephropathy-caused-by-tosufloxacin
#2
Risa Matsubara, Tetsuya Kibe, Takemasa Nomura
A 14-year-old girl was treated for 3 days with tosufloxacin (450 mg twice a day) for acute bronchitis and then developed acute kidney injury. Renal ultrasound showed enlarged kidneys without hydronephrosis. Urinalysis indicated drug crystal casts (2-3/HPF), consistent with drug-induced crystalline nephropathy. The patient recovered gradually with i.v. hydration and discontinuation of tosufloxacin, leading to the diagnosis of tosufloxacin crystalline nephropathy. Medical practitioners should be aware that crystalline nephropathy can occur in pediatric patients receiving tosufloxacin...
November 2016: Pediatrics International: Official Journal of the Japan Pediatric Society
https://www.readbyqxmd.com/read/27872232/therapeutic-potential-of-progranulin-in-hyperhomocysteinemia-induced-cardiorenal-dysfunction
#3
Yi Fu, Yu Sun, Meng Zhou, Xiaojie Wang, Ziying Wang, Xinbing Wei, Yan Zhang, Zeyu Su, Kaili Liang, Wei Tang, Fan Yi
Hyperhomocysteinemia (hHcys) is an important independent risk factor for the development of cardiovascular disease and end-stage renal disease. Although multiple approaches lowering the levels of homocysteine have been used in experimental studies and clinical trials, there is no effective therapy available to fully prevent homocysteine-induced injury. Therefore, identifying key molecules in the pathogenic pathways may provide clues to develop new therapeutic strategies for the treatment of hHcys-associated injury beyond lowering the plasma homocysteine levels...
November 21, 2016: Hypertension
https://www.readbyqxmd.com/read/27867530/continuous-renal-replacement-therapy-for-haemodynamic-collapse-and-rhabdomyolysis-induced-by-pheochromocytoma-crisis
#4
Xi Zhou, Chuhuan Zhao, Xiafei Feng, Anweshan Samanta, Yi Nuo Lin, Jun Chen, Xiaochun Dai, Xia Hong, Qiangli Xie, Weijian Huang
Pheochromocytoma associated with pregnancy is not common. Caesarean section may induce pheochromocytoma crisis, resulting in a lethal condition. The clinical picture of pheochromocytoma crisis is extremely variable. In this report, we describe a case of severe pheochromocytoma crisis induced by caesarean section presenting with hyperpyrexia, haemodynamic collapse, muscle weakness, heart failure, and acute kidney injury. Furthermore, we report that the muscle weakness was a manifestation of rhabdomyolysis, resulting from the pheochromocytoma crisis...
December 2016: ESC Heart Failure
https://www.readbyqxmd.com/read/27858871/case-report-brincidofovir-induced-reversible-severe-acute-kidney-injury-in-2-solid-organ-transplant-for-treatment-of-cytomegalovirus-infection
#5
Emmanuel Faure, Tatiana Galperine, Olivier Cannesson, Sophie Alain, Viviane Gnemmi, Celine Goeminne, Annie Dewilde, Johana Béné, Mohamed Lasri, Célia Lessore de Sainte Foy, Arnaud Lionet
RATIONALE: Resistant cytomegalovirus-mediated infections are increasing in solid organ recipient with few available alternative treatments. Brincidofovir is an oral broad-spectrum antiviral in development for prevention and treatment of viral infection, particularly cytomegalovirus. PATIENTS CONCERNS: Although brincidofovir is an analogue of cidofovir, previous studies reported no renal toxicity. DIAGNOSES: Here, we report 2 cases of severe tubular necrosis in solid organ recipients, 1 heart and 1 kidney transplant...
November 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27832180/cordyceps-militaris-treatment-preserves-renal-function-in-type-2-diabetic-nephropathy-mice
#6
Sung-Hsun Yu, Navneet Kumar Dubey, Wei-Shan Li, Ming-Che Liu, Han-Sun Chiang, Sy-Jye Leu, Ying-Hua Shieh, Feng-Chou Tsai, Win-Ping Deng
Diabetic nephropathy is derived from long-term effects of high blood glucose on kidney function in type 2 diabetic patients. Several antidiabetic drugs and herbal medications have failed to prevent episodes of DN. Hence, this study aimed to further investigate the renal injury-reducing effect of antidiabetic CmNo1, a novel combination of powders of fruiting bodies and mycelia of Cordyceps militaris. After being administered with streptozotocin-nicotinamide and high-fat-diet, the diabetic nephropathy mouse model displayed elevated blood glucose and renal dysfunction markers including serum creatinine and kidney-to-body weight ratio...
2016: PloS One
https://www.readbyqxmd.com/read/27820741/does-fluid-management-affect-the-occurrence-of-acute-kidney-injury
#7
Johan Mårtensson, Rinaldo Bellomo
PURPOSE OF REVIEW: To describe the potential impact of different fluid management strategies on renal outcomes in critically ill and postoperative patients. RECENT FINDINGS: Uncritical fluid administration may induce renal compartment syndrome and renal venous congestion, which contribute to kidney dysfunction. In more than 5000 randomized surgical or septic patients, goal-directed therapy did not reduce fluid accumulation, acute kidney injury (AKI) development or need for renal replacement therapy...
November 4, 2016: Current Opinion in Anaesthesiology
https://www.readbyqxmd.com/read/27809280/role-of-oxidative-stress-in-drug-induced-kidney-injury
#8
REVIEW
Keiko Hosohata
The kidney plays a primary role in maintaining homeostasis and detoxification of numerous hydrophilic xenobiotics as well as endogenous compounds. Because the kidney is exposed to a larger proportion and higher concentration of drugs and toxins than other organs through the secretion of ionic drugs by tubular organic ion transporters across the luminal membranes of renal tubular epithelial cells, and through the reabsorption of filtered toxins into the lumen of the tubule, these cells are at greater risk for injury...
November 1, 2016: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/27801920/hydralazine-induced-anca-vasculitis-in-the-setting-of-acute-clostridium-difficile-infection
#9
Somwail Rasla, Amr El Meligy, Dragos F Cucu
We report a rare case of Hydralazine-induced ANCA associated glomerulonephritis with alveolar hemorrhage in the setting of acute Clostridium Difficile Infection. A 71-year-old Caucasian woman with hypertension, who was being treated with hydralazine 25 mg twice a day for six years, presented to the hospital with diarrhea, nausea, vomiting and anemia. She had acute kidney injury and urinalysis showed proteinuria, dysmorphic RBCs, and rare RBC cast. She was found to have Clostridium difficile colitis which was successfully treated...
November 1, 2016: Rhode Island Medical Journal
https://www.readbyqxmd.com/read/27799149/dtb-select-11-november-2016
#10
(no author information available yet)
Impact of hepatic enzyme-inducing drugs on levonorgestrel EHC ● New clinical rule to improve antibiotic prescribing to children ● The impact of nursery sickness policies on the treatment of conjunctivitis ● Patient safety alert for acute kidney injury ● Do strategies to reduce polypharmacy improve patient-relevant outcomes? ● When is a health app a medical device? ● Automated feedback reduces high-risk prescribing in primary care ● Quantifying resting heart rate as a predictor of disease.
October 31, 2016: Drug and Therapeutics Bulletin
https://www.readbyqxmd.com/read/27761927/hypercalcaemia-induced-kidney-injury-caused-by-the-vitamin-d-analogue-calcitriol-for-psoriasis-a-note-of-caution-when-prescribing-topical-treatment
#11
E Corden, E Higgins, C Smith
A 55-year-old man with severe plaque psoriasis presented with a 2-week history of feeling generally unwell with lethargy and thirst. His symptoms had developed 6 weeks after commencement of the topical vitamin D3 analogue calcitriol. Investigations revealed hypercalcaemia and acute-on-chronic kidney injury, probably directly induced by systemic absorption of vitamin D3 following extensive topical use. Topical calcitriol had been started as a steroid-sparing agent to reduce the patient's liberal potent corticosteroid usage during anti-tumour necrosis factor-alfa therapy...
October 20, 2016: Clinical and Experimental Dermatology
https://www.readbyqxmd.com/read/27734446/exertional-rhabdomyolysis-epidemiology-diagnosis-treatment-and-prevention
#12
Joseph J Knapik, Francis G O'Connor
Exertional rhabdomyolysis (ER) is a medical condition whereby damage to skeletal muscle is induced by excessive physical activity in otherwise healthy individuals. The individual performs so much activity that he/ she presumably depletes local muscle energy stores and muscle cells are unable to maintain cellular integrity, resulting in cell damage and the release of cellular contents, with resultant secondary complications. In the military services, the incidence of ER appeared to increase in the period 2004 to 2015...
2016: Journal of Special Operations Medicine: a Peer Reviewed Journal for SOF Medical Professionals
https://www.readbyqxmd.com/read/27686059/a-randomised-controlled-trial-evaluating-renal-protective-effects-of-selenium-with-vitamins-a-c-e-verapamil-and-losartan-against-extracorporeal-shockwave-lithotripsy-induced-renal-injury
#13
Ahmed R El-Nahas, Mohamed M Elsaadany, Diaa-Eldin Taha, Ahmed M Elshal, Mohamed Abo El-Ghar, Amani M Ismail, Essam A Elsawy, Hazem H Saleh, Ehab W Wafa, Amira Awadalla, Tamer S Barakat, Khaled Z Sheir
OBJECTIVE: To evaluate the protective effects of selenium with vitamins A, C and E (selenium ACE, i.e. antioxidants), verapamil (calcium channel blocker), and losartan (angiotensin receptor blocker) against extracorporeal shockwave lithotripsy (ESWL)-induced renal injury. PATIENTS AND METHODS: A randomised controlled trial was conducted between August 2012 and February 2015. Inclusion criteria were adult patients with a single renal stone (<2 cm) suitable for ESWL...
September 30, 2016: BJU International
https://www.readbyqxmd.com/read/27682899/combined-hydration-and-antibiotics-with-lisinopril-to-mitigate-acute-and-delayed-high-dose-radiation-injuries-to-multiple-organs
#14
Brian L Fish, Feng Gao, Jayashree Narayanan, Carmen Bergom, Elizabeth R Jacobs, Eric P Cohen, John E Moulder, Christie M Orschell, Meetha Medhora
The NIAID Radiation and Nuclear Countermeasures Program is developing medical agents to mitigate the acute and delayed effects of radiation that may occur from a radionuclear attack or accident. To date, most such medical countermeasures have been developed for single organ injuries. Angiotensin converting enzyme (ACE) inhibitors have been used to mitigate radiation-induced lung, skin, brain, and renal injuries in rats. ACE inhibitors have also been reported to decrease normal tissue complication in radiation oncology patients...
November 2016: Health Physics
https://www.readbyqxmd.com/read/27661440/medication-induced-acute-kidney-injury
#15
Stuart L Goldstein
PURPOSE OF REVIEW: The present article will review the current state of our understanding of nephrotoxic medication-associated acute kidney injury (AKI) and provide strategies to reduce its impact. RECENT FINDINGS: Nephrotoxic medications contribute to a substantial proportion of AKI in hospitalized patients. The previous perspective of nephrotoxic medication-associated AKI as a nonmodifiable necessary evil of providing appropriate therapy to ill patients had led to an incomplete understanding of its epidemiology and provided little impetus to reduce its occurrence...
December 2016: Current Opinion in Critical Care
https://www.readbyqxmd.com/read/27631009/establishment-of-simple-and-routine-methods-in-early-diagnosis-of-gentamicin-induced-kidney-injury-based-on-a-rat-model
#16
Cuiyan Liu, Youxi Kang, Huiqin Zhang, Long Zhu, Hai Yu, Chunyang Han
The changes in biomarkers of gentamycin- (GM-) induced kidney injury have been studied by using simple and routine methods and also assessed the efficacy and utility of these routine biomarkers in early diagnosis. Eighty Sprague-Dawley (SD) rats were randomly divided into 4 groups: three experimental groups treated with different GM dosages (4, 20, and 100 mg·kg(-1)) and a control group. The experimental groups were given intramuscular GM injections once daily for 14 days, and the control group was given intramuscular sterile water...
2016: BioMed Research International
https://www.readbyqxmd.com/read/27607474/baseline-pulse-pressure-acute-kidney-injury-and-mortality-after-noncardiac-surgery
#17
Adriana D Oprea, Frederick W Lombard, Wen-Wei Liu, William D White, Jörn A Karhausen, Yi-Ju Li, Timothy E Miller, Solomon Aronson, Tong J Gan, Manuel L Fontes, Miklos D Kertai
BACKGROUND: Increased pulse pressure (PP) is an important independent predictor of cardiovascular outcome and acute kidney injury (AKI) after cardiac surgery. The objective of this study was to determine whether elevated baseline PP is associated with postoperative AKI and 30-day mortality after noncardiac surgery. METHODS: We evaluated 9125 adult patients who underwent noncardiac surgery at Duke University Medical Center between January 2006 and December 2009. Baseline arterial blood pressure was defined as the mean of the first 5 measurements recorded by the automated record keeping system before inducing anesthesia...
December 2016: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/27510875/-clinical-and-pathological-analysis-of-iga-nephropathy-with-acute-kidney-injury
#18
M G Chen, X H Ye, H Y Liang, Q Yang
OBJECTIVE: To investigate the incidence, etiology, clinico- pathological characteristics and prognosis in primary IgA nephropathy (IgAN) children with acute kidney injury (AKI). METHOD: Retrospective analysis of the clinical and pathological manifestations and follow-up results of 19 Chlidren, who were associated with AKI in 196 cases of children with IgA nephropathy treated in our department from January, 1996 to Jun, 2012 was performed. RESULT: (1) The 19 cases associated with AKI accounted for 9...
August 2016: Zhonghua Er Ke za Zhi. Chinese Journal of Pediatrics
https://www.readbyqxmd.com/read/27493118/%C3%A2-early-initiation-of-mars%C3%A2-dialysis-in-amanita-phalloides-induced-acute-liver-injury-prevents-liver-transplantation
#19
Mike Hendrik Pillukat, Tina Schomacher, Peter Baier, Gert Gabriëls, Hermann Pavenstädt, Hartmut H J Schmidt
 Amanita phalloides is the most relevant mushroom intoxication leading to acute liver failure. The two principal groups of toxins, the amatoxins and the phallotoxins, are small oligopeptides highly resistant to chemical and physical influences. The amatoxins inhibit eukaryotic RNA polymerase II causing transcription arrest affecting mainly metabolically highly active cells like hepatocytes and renal cells. The clinically most characteristic symptom is a 6-40 h lag phase before onset of gastrointestinal symptoms and the rapid progression of acute liver failure leading to multi-organ failure and death within a week if left untreated...
September 2016: Annals of Hepatology
https://www.readbyqxmd.com/read/27466238/hundred-top-cited-articles-focusing-on-acute-kidney-injury-a-bibliometric-analysis
#20
Yuan-Hui Liu, Sheng-Qi Wang, Jin-Hua Xue, Yong Liu, Ji-Yan Chen, Guo-Feng Li, Peng-Cheng He, Ning Tan
BACKGROUND: Acute kidney injury (AKI) is a major global health issue, associated with poor short-term and long-term outcomes. Research on AKI is increasing with numerous articles published. However, the quantity and quality of research production in the field of AKI is unclear. METHODS AND ANALYSIS: To analyse the characteristics of the most cited articles on AKI and to provide information about achievements and developments in AKI, we searched the Science Citation Index Expanded for citations of AKI articles...
July 27, 2016: BMJ Open
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