Maxime Bonnet, Céline Ertlen, Mostafa Seblani, Jean-Michel Brezun, Thelma Coyle, Cristina Cereda, Gianvincenzo Zuccotti, Mattia Colli, Christophe Desouches, Patrick Decherchi, Stephana Carelli, Tanguy Marqueste
Traumatic spinal cord injuries (SCIs) often result in sensory, motor, and vegetative function loss below the injury site. Although preclinical results have been promising, significant solutions for SCI patients have not been achieved through translating repair strategies to clinical trials. In this study, we investigated the effective potential of mechanically activated lipoaspirated adipose tissue when transplanted into the epicenter of a thoracic spinal contusion. Male Sprague Dawley rats were divided into three experimental groups: SHAM (uninjured and untreated), NaCl (spinal cord contusion with NaCl application), and AF (spinal cord contusion with transplanted activated human fat)...
January 17, 2024: Cells