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Phyto steroid

Galib Ruknuddin, B J Patgiri, P K Prajapati, B K Ashok, B Ravishankar
INTRODUCTION: Arthritis is the most common cause of disability, limiting the activities of adults throughout the world. Apart from the conventional treatment strategies using non-steroidal anti-inflammatory drugs, disease-modifying anti-rheumatic drugs, and glucocorticoids, newer and safer drugs are continuously being searched, as long-term usage of these drugs have resulted in adverse effects. Besides this, currently a number of medicinal plants are under scientific evaluation to develop a promising remedy in these cases...
January 2015: Toxicology International
Eric R Prossnitz, Jeffrey B Arterburn
Estrogens are critical mediators of multiple and diverse physiologic effects throughout the body in both sexes, including the reproductive, cardiovascular, endocrine, nervous, and immune systems. As such, alterations in estrogen function play important roles in many diseases and pathophysiological conditions (including cancer), exemplified by the lower prevalence of many diseases in premenopausal women. Estrogens mediate their effects through multiple cellular receptors, including the nuclear receptor family (ERα and ERβ) and the G protein-coupled receptor (GPCR) family (GPR30/G protein-coupled estrogen receptor [GPER])...
July 2015: Pharmacological Reviews
Monojit Debnath, Moulisha Biswas, Vinay J Shukla, K Nishteswar
BACKGROUND: Jyotishmati (Celastrus paniculatus Willd.) is a woody climber belongs to the family Celastraceae; a well known herbal nootropic, distributed through the tropical and subtropical regions of India. Its leaves are used in eye disease and headache. Very low qualitative and quantitative information about leaves have been documented to establish its quality and purity. AIM: Present study was conducted to evaluate physicochemical, phyto-chemical and HPTLC analysis of different solvent extracts of the C...
January 2014: Ayu
G K Ainooson, G Owusu, E Woode, C Ansah, K Annan
Trichilia monadelpha (Thonn) JJ De Wilde (Meliaceae) bark extract is used in African traditional medicine for the management of various disease conditions including inflammatory disorders such as arthritis. The present study was undertaken to evaluate the anti-inflammatory properties of aqueous (TWE), alcoholic (TAE) and petroleum ether extract (TPEE) of T. monadelpha using the 7-day old chick-carrageenan footpad oedema (acute inflammation) and the adjuvant-induced arthritis model in rats (chronic inflammation)...
2012: African Journal of Traditional, Complementary, and Alternative Medicines: AJTCAM
Bhavna N Desai, Radha H Maharjan, Laxmipriya P Nampoothiri
BACKGROUND: Polycystic ovarian syndrome (PCOS), characterized by ovulatory infertility and hyperandrogenism, is associated with metabolic complications such as dyslipidemia, insulin resistance and endothelial dysfunction. Almost 70% PCOS women have abnormal serum lipid levels (dyslipidemia) and 50% of these women are obese. Several classes of pharmacological agents have been used to manage dyslipidemia. However, studies have shown adverse effects associated with these drugs. In the light of alternate therapy, many medicinal herbs have been reported to show hypoglycemic, anti-hyperlipidemic potential...
April 2012: Pharmacognosy Research
D V Babaskin, P N Chuntomov, I A Pozhidaev, E G Mosolova, A V Ter-Ovakimian
The objective of the present comparative study was to estimate the efficacy of the rehabilitative treatment of the patients presenting with knee joint osteoarthrosis using sinusoidal modulated current electrophoresis of a phytopreparation. It was shown that the combination of phyto- and electrotherapies allows to more efficaciously alleviate pain in the knee joint and improve its function than pharmacotherapy or its combination with amplipulse therapy. The proposed approach produces no adverse effects. Its ultimate effect is a marked improvement of the patients' quality of life...
November 2011: Voprosy Kurortologii, Fizioterapii, i Lechebnoĭ Fizicheskoĭ Kultury
Yuva Bellik, Si M Hammoudi, Fatiha Abdellah, Mokrane Iguer-Ouada, Laïd Boukraâ
Recently, much interest has been generated for a wide range of phyto-constituents with reports demonstrating their role in the modulation of inflammatory responses, including phenolics, alkaloids, and terpenoids. Natural products have long been, over the years, contributed to the development of modern therapeutic drugs. At present, steroids, antihistaminic drugs, suppressants or inhibitors of the release of mediators and the like have been used as anti-allergic agents. However, some of them lack immediate effectiveness or have central side effects...
May 2012: Recent Patents on Inflammation & Allergy Drug Discovery
Chandana C Barua, Archana Talukdar, Shameem Ara Begum, Prabodh Borah, Mangala Lahkar
OBJECTIVE: To study the anxiolytic activity of methanol extract of Achyranthes aspera Linn (Amaranthaceae). MATERIALS AND METHODS: Male Swiss albino mice were used. Methanolic extract of Achyranthes aspera (MEAA) was administered in the doses of 100, 300 and 600 mg/kg p.o. Hole board (HB), open field (OF), elevated plus maze (EPM) and light/dark exploration (LDE) tests were used for determination of anxiolytic activity. RESULTS: The methanolic extract of Achyranthes aspera significantly increased the number and duration of head poking in HB test...
January 2012: Indian Journal of Pharmacology
Sophie S Chen, Agnieszka Michael, Simon A Butler-Manuel
Epithelial ovarian cancer (EOC) is the leading cause of death among gynecological malignancies worldwide. The five-year survival rates for stage IIIC and IV patients are 29% and 13%, respectively. Type-2 EOC cells have been found to be associated with this late stage disease. In contrast, women diagnosed in stage 1 disease, which mostly exhibits type-1 cells, have a high 5-year survival rate (90%). Recent progress in understanding the pathogenesis of EOC and inflammatory signaling pathways revealed that type-2 cells frequently express a deleted or mutated TP53 (60-80%), or aberrations in BRCA1 (30-60%) and BRCA2 (15-30%)...
January 2012: Discovery Medicine
Alexander Yemelyanov, Pankaj Bhalla, Ximing Yang, Andrey Ugolkov, Kenichi Iwadate, Apollon Karseladze, Irina Budunova
Androgen (AR) and glucocorticoid (GR) receptor signaling play opposing roles in prostate tumorigenesis: in prostate, AR acts as an oncogene, and GR is a tumor suppressor. Recently, we found that non-steroidal phyto-chemical Compound A (CpdA) is AR/GR modulator acting as anti-inflammatory anti-androgen. CpdA inhibits AR and prevents GR transactivation while enhancing GR transrepression. GR and AR are controlled by proteasomal degradation. We found that prolonged exposure of LNCaP, LNCaP-GR, DU145 and PC3 prostate carcinoma (PCa) cells to proteasome inhibitor Bortezomib (BZ) caused AR degradation and GR accumulation...
January 15, 2012: Cell Cycle
Vimala Thankappan Anitha, Johnson Marimuthu Antonisamy, Solomon Jeeva
OBJECTIVE: To examine the ethanol, aqueous, chloroform, benzene, acetone and petroleum ether extracts of, Hemigraphis colorata (H. colorata) leaves and stem and Elephantopus scaber (E. scaber) leaves, root and flower for the presence of phyto-constituents and screened the anti-bacterial activity against the selected pathogens. METHODS: The fresh materials were shade dried and powdered using the tissue blender. The dried and powered materials (50 g) were extracted successively with 200 mL of aqueous, acetone, benzene, chloroform, ethanol, and petroleum ether by using Soxhlet extractor for 8 h at a temperature not exceeding the boiling point of the solvent...
January 2012: Asian Pacific Journal of Tropical Medicine
Vassiliki Pelekanou, Guy Leclercq
The present work reviews recent findings related to the action of steroidal (physiological) estrogens on normal mammary gland development and carcinogenesis, as well as effects of related environmental mediators (phyto- and xeno-estrogens), the role of which remains controversial. Orchestration by estrogen receptors (i.e. ERα and ERβ) and coregulators of growth, apoptosis and differentiation of epithelial cells, directed our analysis. The bidirectional coordination between epithelium and stroma in parallel with maintenance of stemness are also investigated...
2011: International Journal of Developmental Biology
Radha Maharjan, Padamnabhi S Nagar, Laxmipriya Nampoothiri
This is a preliminary study that explores the efficacy of Aloe vera gel formulation as a possible therapeutic agent in the prevention and management of polycystic ovary syndrome (PCOS). PCOS is recognized as the most common endocrinopathy of women. Increased androgen synthesis, disrupted folliculogenesis, and insulin resistance lie at the patho-physiological core of PCOS. Current therapy for such a syndrome is use of insulin sensitizers. Large randomized clinical trials of metformin as the insulin-sensitizing drug, however, suggested that it produces many side effects after prolonged usage...
October 2010: Journal of Ayurveda and Integrative Medicine
Chandana Choudhury Barua, Jayanti Datta Roy, Bhaben Buragohain, Acheenta Gohain Barua, Prabodh Borah, Mangala Lahkar
OBJECTIVES: To study the analgesic and anti-nociceptive activity of hydroethanolic extract of Drymaria cordata Willd. MATERIALS AND METHODS: Wistar rats and Swiss albino mice were used for studying analgesic and anti-nociceptive activity of Drymaria cordata hydroethanolic extract (DCHE) at doses 50, 100 and 200 mg/kg p.o. Various models viz. acetic acid induced writhing model (female mice), Eddy's hot plate (mice) and tail flick model (rat) for analgesic study and formalin-induced paw licking model (mice) were used for anti-nociceptive study...
April 2011: Indian Journal of Pharmacology
T Lóránd, E Vigh, J Garai
Herbivorous and omnivorous vertebrates have evolved in the presence of a variety of phytoestrogens, i.e., plant-derived compounds that can mimic, modulate or disrupt the actions of endogenous estrogens. Since the discovery of the estrus-inducing effects of some plant products in 1926, considerable effort has been devoted to the isolation and structural and pharmacological characterization of phytoestrogens. Recently, agricultural and industrial pollution has added anthropogenic estrogenic compounds to the list of environmental estrogens...
2010: Current Medicinal Chemistry
G Basini, S Bussolati, S E Santini, F Grasselli
Soya and soybean products used in swine feeding contain genistein, a non-steroidal phyto-oestrogen which has been demonstrated to influence endocrine functions. This observation leads us to design this study to evaluate the effect of genistein on swine granulosa cell steroidogenesis and proliferation. In the attempt to unravel the genistein signal transduction mechanisms, we verified the effect of lavendustin, a Tyrosine Kinase (TK) inhibitor, and the potential involvement of NO/cGMP pathway. Finally, as angiogenesis is essential for follicle development, we tested the effect of the phyto-oestrogen on vascular endothelial growth factor production and on granulosa cell redox status, because free-radical species modulate neovascularization...
December 2010: Journal of Animal Physiology and Animal Nutrition
Hao Wang, Jiang Li, Yang Gao, Ying Xu, Ying Pan, Ichiro Tsuji, Zi-Jie Sun, Xiao-Meng Li
The androgen receptor (AR) plays a critical role in prostate cancer development and progression. This study aimed to use a computerized docking approach to examine the interactions between the human AR and phyto-oestrogens (genistein, daidzein, and flavone) and xeno-oestrogens (bisphenol A, 4-nonylphenol, dichlorodiphenyl trichloroethane [DDT], diethylstilbestrol [DES]). The predicted three-dimensional structure of AR and androgens was established using X-ray diffraction. The binding of four xeno-oestrogens and three phyto-oestrogens to AR was analysed...
July 2010: Asian Journal of Andrology
Ji-Won Lee, Yasuhiro Kobayashi, Yuko Nakamichi, Nobuyuki Udagawa, Naoyuki Takahashi, Nam-Kyung Im, Hwa-Jeong Seo, Won Bae Jeon, Takayuki Yonezawa, Byung-Yoon Cha, Je-Tae Woo
Osteoclasts, bone-resorbing multinucleated cells, are differentiated from hemopoietic progenitors of the monocyte/macrophage lineage. Bone resorption by osteoclasts is considered a potential therapeutic target to the treatment of erosive bone diseases, including osteoporosis, rheumatoid arthritis, and periodontitis. In the present study, we found that alisol-B, a phyto-steroid from Alisma orientale Juzepczuk, exhibited inhibitory effects on osteoclastogenesis both in vitro and in vivo. Although RT-PCR analysis showed that alisol-B did not affect the 1alpha,25(OH)(2)D(3)-induced expressions of RANKL, OPG and M-CSF mRNAs in osteoblasts, addition of alisol-B to co-cultures of mouse bone marrow cells and primary osteoblasts with 10(-8)M 1alpha,25(OH)(2)D(3) caused significant inhibition of osteoclastogenesis...
August 1, 2010: Biochemical Pharmacology
Said Kinani, Stéphane Bouchonnet, Nicolas Creusot, Sophie Bourcier, Patrick Balaguer, Jean-Marc Porcher, Sélim Aït-Aïssa
A comprehensive evaluation of organic contamination was performed in sediments sampled in two reference and three impacted small streams where endocrine disruptive (ED) effects in fish have been evidenced. The approach combined quantitative chemical analyses of more than 50 ED chemicals (EDCs) and a battery of in vitro bioassays allowing the quantification of receptor-mediated activities, namely estrogen (ER), androgen (AR), dioxin (AhR) and pregnane X (PXR) receptors. At the most impacted sites, chemical analyses showed the presence of natural estrogens, organochlorine pesticides, parabens, polycyclic aromatic hydrocarbons (16 PAHs), bisphenol A and alkylphenols, while synthetic steroids, myco-estrogens and phyto-estrogens were not detected...
January 2010: Environmental Pollution
Nishant P Visavadiya, A V R L Narasimhacharya
Hyperlipidemia/hypercholesteremia are major risk factors for atherosclerosis and cardiovascular diseases. Root of Asparagus racemosus (AR) is widely used in Ayurvedic system of medicine in India and is known for its steroidal saponin content. This study was designed to investigate the hypocholesteremic and antioxidant potential of AR root in both normo- and hypercholesteremic animals. Normal and hypercholesteremic male albino rats were administered with root powder of AR (5 and 10 g% dose levels) along with normal and hypercholesteremic diets, respectively, for a duration of 4 weeks...
June 2009: Evidence-based Complementary and Alternative Medicine: ECAM
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