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https://www.readbyqxmd.com/read/28967359/the-role-of-centralised-pain-in-osteoarthritis
#1
REVIEW
Daniel J Clauw, Afton L Hassett
The mechanisms underlying chronic pain states, including osteoarthritis, differ from those underlying acute pain. In chronic pain states, central nervous system (CNS) factors often play a particularly prominent role. In many individuals with chronic pain, pain can occur with minimal or no evidence of ongoing nociceptive input. Medical subspecialties have applied a wide-range of labels to these pain conditions including fibromyalgia, irritable bowel syndrome and interstitial cystitis to name just a few. These same CNS processes can augment or magnify pain when there is ongoing nociceptive input, as in conditions such as osteoarthritis or autoimmune disorders...
September 2017: Clinical and Experimental Rheumatology
https://www.readbyqxmd.com/read/28943233/unravelling-fibromyalgia-steps-towards-individualized-management
#2
Winfried Häuser, Serge Perrot, Daniel J Clauw, Mary-Ann Fitzcharles
The heterogeneity of the clinical presentation and the pathophysiologic mechanisms associated with fibromyalgia (FM), and the modest results on average for any therapy, call for a more individualized management strategy. Individualized treatment can be based on subgrouping of patients according to associated conditions (mental health problems; chronic overlapping pain conditions; other somatic diseases) or on the disease severity. Categorizing FM as mild, moderate or severe can be based on clinical assessment (e...
September 21, 2017: Journal of Pain: Official Journal of the American Pain Society
https://www.readbyqxmd.com/read/28814895/caffeine-as-an-opioid-analgesic-adjuvant-in-fibromyalgia
#3
J Ryan Scott, Afton L Hassett, Chad M Brummett, Richard E Harris, Daniel J Clauw, Steven E Harte
BACKGROUND: Caffeine's properties as an analgesic adjuvant with nonsteroidal anti-inflammatory drugs/acetaminophen are well documented. However, little clinical research has explored caffeine's effects on opioid analgesia. This study assessed the effects of caffeine consumption on pain and other symptoms in opioid-using and nonusing chronic pain patients meeting the survey criteria for fibromyalgia. MATERIALS AND METHODS: Patients presenting to a university-based pain clinic completed validated self-report questionnaires assessing symptoms...
2017: Journal of Pain Research
https://www.readbyqxmd.com/read/28796118/emotional-awareness-and-expression-therapy-cognitive-behavioral-therapy-and-education-for-fibromyalgia-a-cluster-randomized-controlled-trial
#4
Mark A Lumley, Howard Schubiner, Nancy A Lockhart, Kelley M Kidwell, Steven E Harte, Daniel J Clauw, David A Williams
Patients with fibromyalgia (FM) experience increased lifetime levels of psychosocial adversity, trauma, and emotional conflict. To address these risk factors, we developed emotion awareness and expression therapy (EAET) and tested its benefits against an active control condition, FM education, and the field's gold standard intervention for FM, cognitive behavioral therapy (CBT) for symptom management. Adults with FM (N = 230) formed 40 treatment groups, which were randomized to EAET, CBT, or education and given 8, 90-minute sessions...
August 8, 2017: Pain
https://www.readbyqxmd.com/read/28692006/brain-signature-and-functional-impact-of-centralized-pain-a-multidisciplinary-approach-to-the-study-of-chronic-pelvic-pain-mapp-network-study
#5
Jason J Kutch, Eric Ichesco, Johnson P Hampson, Jennifer S Labus, Melissa A Farmer, Katherine T Martucci, Timothy J Ness, Georg Deutsch, A Vania Apkarian, Sean C Mackey, David J Klumpp, Anthony J Schaeffer, Larissa V Rodriguez, Karl J Kreder, Dedra Buchwald, Gerald L Andriole, H Henry Lai, Chris Mullins, John W Kusek, J Richard Landis, Emeran A Mayer, J Quentin Clemens, Daniel J Clauw, Richard E Harris
Chronic pain is often measured with a severity score that overlooks its spatial distribution across the body. This widespread pain is believed to be a marker of centralization, a central nervous system process that decouples pain perception from nociceptive input. Here, we investigated whether centralization is manifested at the level of the brain using data from 1079 participants in the Multidisciplinary Approach to the Study of Chronic Pelvic Pain Research Network (MAPP) study. Participants with a clinical diagnosis of urological chronic pelvic pain syndrome (UCPPS) were compared to pain-free controls and patients with fibromyalgia, the prototypical centralized pain disorder...
June 30, 2017: Pain
https://www.readbyqxmd.com/read/28562155/challenges-of-implementing-fibromyalgia-treatment-guidelines-in-current-clinical-practice
#6
REVIEW
Lesley M Arnold, Daniel J Clauw
The current diagnostic and treatment pathway for patients with fibromyalgia (FM) is lengthy, complex, and characterized by multiple physician visits with an average 2-year wait until diagnosis. It is clear that effective identification and appropriate treatment of FM remain a challenge in current clinical practice. Ideally, FM management involves a multidisciplinary approach with the preferable patient pathway originating in primary care but supported by a range of health care providers, including referral to specialist care when necessary...
September 2017: Postgraduate Medicine
https://www.readbyqxmd.com/read/28319509/a-high-preoperative-pain-and-symptom-profile-predicts-worse-pain-outcomes-for-children-after-spine-fusion-surgery
#7
Terri Voepel-Lewis, Michelle S Caird, Alan R Tait, Shobha Malviya, Frances A Farley, Ying Li, Matthew D Abbott, Tara van Veen, Afton L Hassett, Daniel J Clauw
BACKGROUND: Preoperative pain predicts persistent pain after spine fusion, yet little is understood about the nature of that pain, related symptoms, and how these symptoms relate to postoperative pain outcomes. This prospective study examined children's baseline pain and symptom profiles and the association between a high symptom profile and postoperative outcomes. METHODS: Seventy children (aged 10-17 years) scheduled for correction of idiopathic scoliosis completed pain and symptom surveys during their preoperative visit (ie, pain intensity [0-10 numeric rating scores], a pediatric version of the 2011 fibromyalgia survey criteria [including pain locations and symptom severity scale], neuropathic pain symptoms [painDETECT], and Patient-Reported Outcome Measurement System measures of fatigue, depression, function, pain interference, and pain catastrophizing)...
May 2017: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/28182834/the-impact-of-moving-from-a-widespread-to-multi-site-pain-definition-on-other-fibromyalgia-symptoms
#8
Linda E Dean, Lesley Arnold, Leslie Crofford, Robert Bennett, Don Goldenberg, Mary-Ann Fitzcharles, Eduardo S Paiva, Roland Staud, Dan Clauw, Piercarlo Sarzi-Puttini, Gareth T Jones, Abimbola Ayorinde, Elisa Fluß, Marcus Beasley, Gary J Macfarlane
OBJECTIVES: The current study investigated whether associations between pain and the additional symptoms associated with fibromyalgia are different in persons with chronic widespread (CWP) compared to multi-site pain (MSP), with or without joint areas. PATIENTS/METHODS: Six studies were utilized: 1958 British birth cohort, EpiFunD, Kid LBP, MUSICIAN, SHAMA and WHEST (females) studies. MSP was defined as the presence of pain in ≥8/≥10 body sites (adults/children) indicated on 4-view body manikins; conducted firstly to include joints (+joints) and secondly without (-joints)...
February 9, 2017: Arthritis Care & Research
https://www.readbyqxmd.com/read/28162746/-495-emotional-abilities-moderate-responses-to-different-psychological-interventions-for-fibromyalgia
#9
H Doherty, N Lockhart, M Lumley, D Williams, H Schubiner, D Clauw
No abstract text is available yet for this article.
April 2016: Journal of Pain: Official Journal of the American Pain Society
https://www.readbyqxmd.com/read/28162316/-509-the-past-fm-pain-and-stress-treatment-for-fibromyalgia-randomized-controlled-trial-main-effects-of-emotional-awareness-and-expression-and-cognitive-behavioral-therapies
#10
M Lumley, H Schubiner, D Clauw, N Lockhart, K Kidwell, D Williams
No abstract text is available yet for this article.
April 2016: Journal of Pain: Official Journal of the American Pain Society
https://www.readbyqxmd.com/read/28050051/discordant-dry-eye-disease-an-american-ophthalmological-society-thesis
#11
Roni M Shtein, Daniel E Harper, Vincent Pallazola, Steven E Harte, Munira Hussain, Alan Sugar, David A Williams, Daniel J Clauw
PURPOSE: To improve understanding of dry eye disease and highlight a subgroup of patients who have a component of central sensitization and neuropathic pain contributing to their condition. METHODS: Prospective, cross-sectional, IRB-approved study comparing isolated dry eye disease (n=48) to fibromyalgia (positive control; n=23) and healthy (negative control; n=26) individuals with ocular surface examination, corneal confocal microscopy, quantitative sensory testing, and self-reported ocular symptoms and systemic associations...
August 2016: Transactions of the American Ophthalmological Society
https://www.readbyqxmd.com/read/27916278/2016-revisions-to-the-2010-2011-fibromyalgia-diagnostic-criteria
#12
Frederick Wolfe, Daniel J Clauw, Mary-Ann Fitzcharles, Don L Goldenberg, Winfried Häuser, Robert L Katz, Philip J Mease, Anthony S Russell, Irwin Jon Russell, Brian Walitt
OBJECTIVES: The provisional criteria of the American College of Rheumatology (ACR) 2010 and the 2011 self-report modification for survey and clinical research are widely used for fibromyalgia diagnosis. To determine the validity, usefulness, potential problems, and modifications required for the criteria, we assessed multiple research reports published in 2010-2016 in order to provide a 2016 update to the criteria. METHODS: We reviewed 14 validation studies that compared 2010/2011 criteria with ACR 1990 classification and clinical criteria, as well as epidemiology, clinical, and databank studies that addressed important criteria-level variables...
December 2016: Seminars in Arthritis and Rheumatism
https://www.readbyqxmd.com/read/27713648/a-novel-paradigm-to-evaluate-conditioned-pain-modulation-in-fibromyalgia
#13
Cynthia J Schoen, Jacob N Ablin, Eric Ichesco, Rupal J Bhavsar, Laura Kochlefl, Richard E Harris, Daniel J Clauw, Richard H Gracely, Steven E Harte
INTRODUCTION: Application of noxious stimulation to one body area reduces pain sensitivity in a remote body area through activation of an endogenous pain-inhibitory network, a behavioral phenomenon referred to as conditioned pain modulation (CPM). The efficiency of CPM is predictive of a variety of health outcomes, while impaired CPM has been associated with various chronic pain conditions. Current methods used to assess CPM vary widely, and interest in CPM method development remains strong...
2016: Journal of Pain Research
https://www.readbyqxmd.com/read/27641311/the-association-between-a-history-of-lifetime-traumatic-events-and-pain-severity-physical-function-and-affective-distress-in-patients-with-chronic-pain
#14
Andrea L Nicol, Christine B Sieberg, Daniel J Clauw, Afton L Hassett, Stephanie E Moser, Chad M Brummett
Evidence suggests that pain patients who report lifetime abuse experience greater psychological distress, have more severe pain and other physical symptoms, and greater functional disability. The aim of the present study was to determine the associations between a history of lifetime abuse and affective distress, fibromyalgianess (measured using the 2011 Fibromyalgia Survey), pain severity and interference, and physical functioning. A cross-sectional analysis of 3,081 individuals presenting with chronic pain was performed using validated measures and a history of abuse was assessed via patient self-report...
December 2016: Journal of Pain: Official Journal of the American Pain Society
https://www.readbyqxmd.com/read/27420606/endogenous-opioidergic-dysregulation-of-pain-in-fibromyalgia-a-pet-and-fmri-study
#15
Andrew Schrepf, Daniel E Harper, Steven E Harte, Heng Wang, Eric Ichesco, Johnson P Hampson, Jon-Kar Zubieta, Daniel J Clauw, Richard E Harris
Endogenous opioid system dysfunction potentially contributes to chronic pain in fibromyalgia (FM), but it is unknown if this dysfunction is related to established neurobiological markers of hyperalgesia. We previously reported that µ-opioid receptor (MOR) availability was reduced in patients with FM as compared with healthy controls in several pain-processing brain regions. In the present study, we compared pain-evoked functional magnetic resonance imaging with endogenous MOR binding and clinical pain ratings in female opioid-naive patients with FM (n = 18) using whole-brain analyses and regions of interest from our previous research...
October 2016: Pain
https://www.readbyqxmd.com/read/27390268/treat-to-target-strategy-for-fibromyalgia-opening-the-dialogue
#16
REVIEW
Winfried Häuser, Daniel J Clauw, Mary-Ann Fitzcharles
No abstract text is available yet for this article.
April 2017: Arthritis Care & Research
https://www.readbyqxmd.com/read/27291641/neurobiology-of-fibromyalgia-and-chronic-widespread-pain
#17
REVIEW
Kathleen A Sluka, Daniel J Clauw
Fibromyalgia is the current term for chronic widespread musculoskeletal pain for which no alternative cause can be identified. The underlying mechanisms, in both human and animal studies, for the continued pain in individuals with fibromyalgia will be explored in this review. There is a substantial amount of support for alterations of central nervous system nociceptive processing in people with fibromyalgia, and that psychological factors such as stress can enhance the pain experience. Emerging evidence has begun exploring other potential mechanisms including a peripheral nervous system component to the generation of pain and the role of systemic inflammation...
December 3, 2016: Neuroscience
https://www.readbyqxmd.com/read/27101425/pharmacologic-attenuation-of-cross-modal-sensory-augmentation-within-the-chronic-pain-insula
#18
Steven E Harte, Eric Ichesco, Johnson P Hampson, Scott J Peltier, Tobias Schmidt-Wilcke, Daniel J Clauw, Richard E Harris
Pain can be elicited through all mammalian sensory pathways yet cross-modal sensory integration, and its relationship to clinical pain, is largely unexplored. Centralized chronic pain conditions such as fibromyalgia are often associated with symptoms of multisensory hypersensitivity. In this study, female patients with fibromyalgia demonstrated cross-modal hypersensitivity to visual and pressure stimuli compared with age- and sex-matched healthy controls. Functional magnetic resonance imaging revealed that insular activity evoked by an aversive level of visual stimulation was associated with the intensity of fibromyalgia pain...
September 2016: Pain
https://www.readbyqxmd.com/read/27022674/fibromyalgia-and-chronic-pain-syndromes-a-white-paper-detailing-current-challenges-in-the-field
#19
Lesley M Arnold, Ernest Choy, Daniel J Clauw, Don L Goldenberg, Richard E Harris, Milton Helfenstein, Troels Staehelin Jensen, Koichi Noguchi, Stuart L Silverman, Takahiro Ushida, Guochun Wang
This manuscript, developed by a group of chronic pain researchers and clinicians from around the world, aims to address the state of knowledge about fibromyalgia (FM) and identify ongoing challenges in the field of FM and other chronic pain syndromes that may be characterized by pain centralization/amplification/hypersensitivity. There have been many exciting developments in research studies of the pathophysiology and treatment of FM and related syndromes that have the potential to improve the recognition and management of patients with FM and other conditions with FM-like pain...
September 2016: Clinical Journal of Pain
https://www.readbyqxmd.com/read/26975749/opioid-use-in-fibromyalgia-a-cautionary-tale
#20
REVIEW
Don L Goldenberg, Daniel J Clauw, Roy E Palmer, Andrew G Clair
Multiple pharmacotherapies are available for the treatment of fibromyalgia (FM), including opioid analgesics. We postulate that the mechanism of action of traditional opioids predicts their lack of efficacy in FM. Literature searches of the MEDLINE and Cochrane Library databases were conducted using the search term opioid AND fibromyalgia to identify relevant articles, with no date limitations set. Citation lists in returned articles and personal archives of references were also examined for additional relevant items, and articles were selected based on the expert opinions of the authors...
May 2016: Mayo Clinic Proceedings
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