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https://www.readbyqxmd.com/read/27713648/a-novel-paradigm-to-evaluate-conditioned-pain-modulation-in-fibromyalgia
#1
Cynthia J Schoen, Jacob N Ablin, Eric Ichesco, Rupal J Bhavsar, Laura Kochlefl, Richard E Harris, Daniel J Clauw, Richard H Gracely, Steven E Harte
INTRODUCTION: Application of noxious stimulation to one body area reduces pain sensitivity in a remote body area through activation of an endogenous pain-inhibitory network, a behavioral phenomenon referred to as conditioned pain modulation (CPM). The efficiency of CPM is predictive of a variety of health outcomes, while impaired CPM has been associated with various chronic pain conditions. Current methods used to assess CPM vary widely, and interest in CPM method development remains strong...
2016: Journal of Pain Research
https://www.readbyqxmd.com/read/27641311/the-association-between-a-history-of-lifetime-traumatic-events-and-pain-severity-physical-function-and-affective-distress-in-patients-with-chronic-pain
#2
Andrea L Nicol, Christine B Sieberg, Daniel J Clauw, Afton L Hassett, Stephanie E Moser, Chad M Brummett
: Evidence suggests that pain patients who report lifetime abuse experience greater psychological distress, have more severe pain and other physical symptoms, and greater functional disability. The aim of the present study was to determine the associations between a history of lifetime abuse and affective distress, fibromyalgianess (measured using the 2011 Fibromyalgia Survey), pain severity and interference, and physical functioning. A cross-sectional analysis of 3,081 individuals presenting with chronic pain was performed using validated measures and a history of abuse was assessed via patient self-report...
September 15, 2016: Journal of Pain: Official Journal of the American Pain Society
https://www.readbyqxmd.com/read/27420606/endogenous-opioidergic-dysregulation-of-pain-in-fibromyalgia-a-pet-and-fmri-study
#3
Andrew Schrepf, Daniel E Harper, Steven E Harte, Heng Wang, Eric Ichesco, Johnson P Hampson, Jon-Kar Zubieta, Daniel J Clauw, Richard E Harris
Endogenous opioid system dysfunction potentially contributes to chronic pain in fibromyalgia (FM), but it is unknown if this dysfunction is related to established neurobiological markers of hyperalgesia. We previously reported that µ-opioid receptor (MOR) availability was reduced in patients with FM as compared with healthy controls in several pain-processing brain regions. In the present study, we compared pain-evoked functional magnetic resonance imaging with endogenous MOR binding and clinical pain ratings in female opioid-naive patients with FM (n = 18) using whole-brain analyses and regions of interest from our previous research...
October 2016: Pain
https://www.readbyqxmd.com/read/27390268/treat-to-target-strategy-for-fibromyalgia-opening-the-dialogue
#4
Winfried Häuser, Daniel J Clauw, Mary-Ann Fitzcharles
No abstract text is available yet for this article.
July 7, 2016: Arthritis Care & Research
https://www.readbyqxmd.com/read/27291641/neurobiology-of-fibromyalgia-and-chronic-widespread-pain
#5
REVIEW
Kathleen A Sluka, Daniel J Clauw
Fibromyalgia is the current term for chronic widespread musculoskeletal pain for which no alternative cause can be identified. The underlying mechanisms, in both human and animal studies, for the continued pain in individuals with fibromyalgia will be explored in this review. There is a substantial amount of support for alterations of central nervous system nociceptive processing in people with fibromyalgia, and that psychological factors such as stress can enhance the pain experience. Emerging evidence has begun exploring other potential mechanisms including a peripheral nervous system component to the generation of pain and the role of systemic inflammation...
December 3, 2016: Neuroscience
https://www.readbyqxmd.com/read/27101425/pharmacologic-attenuation-of-cross-modal-sensory-augmentation-within-the-chronic-pain-insula
#6
Steven E Harte, Eric Ichesco, Johnson P Hampson, Scott J Peltier, Tobias Schmidt-Wilcke, Daniel J Clauw, Richard E Harris
Pain can be elicited through all mammalian sensory pathways yet cross-modal sensory integration, and its relationship to clinical pain, is largely unexplored. Centralized chronic pain conditions such as fibromyalgia are often associated with symptoms of multisensory hypersensitivity. In this study, female patients with fibromyalgia demonstrated cross-modal hypersensitivity to visual and pressure stimuli compared with age- and sex-matched healthy controls. Functional magnetic resonance imaging revealed that insular activity evoked by an aversive level of visual stimulation was associated with the intensity of fibromyalgia pain...
September 2016: Pain
https://www.readbyqxmd.com/read/27022674/fibromyalgia-and-chronic-pain-syndromes-a-white-paper-detailing-current-challenges-in-the-field
#7
Lesley M Arnold, Ernest Choy, Daniel J Clauw, Don L Goldenberg, Richard E Harris, Milton Helfenstein, Troels Staehelin Jensen, Koichi Noguchi, Stuart L Silverman, Takahiro Ushida, Guochun Wang
This manuscript, developed by a group of chronic pain researchers and clinicians from around the world, aims to address the state of knowledge about fibromyalgia (FM) and identify ongoing challenges in the field of FM and other chronic pain syndromes that may be characterized by pain centralization/amplification/hypersensitivity. There have been many exciting developments in research studies of the pathophysiology and treatment of FM and related syndromes that have the potential to improve the recognition and management of patients with FM and other conditions with FM-like pain...
September 2016: Clinical Journal of Pain
https://www.readbyqxmd.com/read/26975749/opioid-use-in-fibromyalgia-a-cautionary-tale
#8
REVIEW
Don L Goldenberg, Daniel J Clauw, Roy E Palmer, Andrew G Clair
Multiple pharmacotherapies are available for the treatment of fibromyalgia (FM), including opioid analgesics. We postulate that the mechanism of action of traditional opioids predicts their lack of efficacy in FM. Literature searches of the MEDLINE and Cochrane Library databases were conducted using the search term opioid AND fibromyalgia to identify relevant articles, with no date limitations set. Citation lists in returned articles and personal archives of references were also examined for additional relevant items, and articles were selected based on the expert opinions of the authors...
May 2016: Mayo Clinic Proceedings
https://www.readbyqxmd.com/read/26842987/changes-in-resting-state-functional-connectivity-after-repetitive-transcranial-direct-current-stimulation-applied-to-motor-cortex-in-fibromyalgia-patients
#9
Chelsea M Cummiford, Thiago D Nascimento, Bradley R Foerster, Daniel J Clauw, Jon-Kar Zubieta, Richard E Harris, Alexandre F DaSilva
BACKGROUND: Fibromyalgia (FM) is a chronic, centralized pain condition characterized by alterations in the functional, chemical, and structural brain networks responsible for sensory and mood processing. Transcranial direct current stimulation (tDCS) has emerged as a potential treatment for FM. tDCS can alter functional connectivity (FC) in brain regions underneath and distant to the stimulating electrode, although the analgesic mechanisms of repetitive tDCS remain unknown. The aim of this study was to investigate how a clinically relevant schedule of tDCS sessions alters resting state FC and how these changes might relate to clinical pain...
2016: Arthritis Research & Therapy
https://www.readbyqxmd.com/read/26835782/preliminary-validation-of-the-michigan-body-map
#10
Chad M Brummett, Rishi R Bakshi, Jenna Goesling, Daniel Leung, Stephanie E Moser, Jennifer W Zollars, David A Williams, Daniel J Clauw, Afton L Hassett
We developed the Michigan Body Map (MBM) as a self-report measure to assess body areas where chronic pain is experienced and to specifically quantify the degree of widespread body pain when assessing for centralized pain features (eg, fibromyalgia-like presentation). A total of 402 patients completed the measure in 5 distinct studies to support the validation of the original and a revised version of the MBM. Administration is rapid 39 to 44 seconds, and errors for the original MBM were detected in only 7.2% of the possible body areas...
June 2016: Pain
https://www.readbyqxmd.com/read/26816332/association-of-alterations-in-gray-matter-volume-with-reduced-evoked-pain-connectivity-following-short-term-administration-of-pregabalin-in-patients-with-fibromyalgia
#11
Tudor Puiu, Anson E Kairys, Lynne Pauer, Tobias Schmidt-Wilcke, Eric Ichesco, Johnson P Hampson, Vitaly Napadow, Daniel J Clauw, Richard E Harris
OBJECTIVE: Pregabalin (PGB) is an α2 δ calcium-channel subunit ligand that has previously been shown to reduce chronic pain in multiple conditions. Preclinical studies indicate that PGB may down-regulate brain glutamate release while also inhibiting astrocyte induction of glutamatergic synapse formation, and recent clinical findings support the notion that PGB modulates glutamatergic activity and functional brain connectivity in order to produce analgesia. The present study was undertaken to examine concurrent changes in brain gray matter volume (GMV) or evoked-pain connectivity in humans receiving PGB...
June 2016: Arthritis & Rheumatology
https://www.readbyqxmd.com/read/26773435/altered-fmri-resting-state-connectivity-in-individuals-with-fibromyalgia-on-acute-pain-stimulation
#12
E Ichesco, T Puiu, J P Hampson, A E Kairys, D J Clauw, S E Harte, S J Peltier, R E Harris, T Schmidt-Wilcke
BACKGROUND: Fibromyalgia is a chronic widespread pain condition, with patients commonly reporting other symptoms such as sleep difficulties, memory complaints and fatigue. The use of magnetic resonance imaging (MRI) in fibromyalgia has allowed for the detection of neural abnormalities, with alterations in brain activation elicited by experimental pain and alterations in resting state connectivity related to clinical pain. METHODS: In this study, we sought to monitor state changes in resting brain connectivity following experimental pressure pain in fibromyalgia patients and healthy controls...
August 2016: European Journal of Pain: EJP
https://www.readbyqxmd.com/read/26628607/effect-of-milnacipran-on-pain-in-patients-with-rheumatoid-arthritis-with-widespread-pain-a-randomized-blinded-crossover-trial
#13
RANDOMIZED CONTROLLED TRIAL
Yvonne C Lee, Elena Massarotti, Robert R Edwards, Bing Lu, ChihChin Liu, Yuanyu Lo, Alyssa Wohlfahrt, Nancy D Kim, Daniel J Clauw, Daniel H Solomon
OBJECTIVE: Clinical trials have shown that serotonin norepinephrine reuptake inhibitors, such as milnacipran, decrease pain in noninflammatory pain conditions such as fibromyalgia and osteoarthritis. We examined the effect of milnacipran on self-reported pain intensity and experimental pain sensitivity among patients with rheumatoid arthritis (RA) with widespread pain and stable RA disease activity. METHODS: In this double-blind, crossover study, patients with RA with widespread pain, receiving a stable treatment regimen, were randomized (by a random number generator) to receive milnacipran 50 mg twice daily or placebo for 6 weeks, followed by a 3-week washout and crossed over to the other arm for the remaining 6 weeks...
January 2016: Journal of Rheumatology
https://www.readbyqxmd.com/read/26548380/efficacy-tolerability-and-safety-of-cannabinoid-treatments-in-the-rheumatic-diseases-a-systematic-review-of-randomized-controlled-trials
#14
Mary-Ann Fitzcharles, Peter A Ste-Marie, Winfried Häuser, Daniel J Clauw, Shahin Jamal, Jacob Karsh, Tara Landry, Sharon Leclercq, Jason J Mcdougall, Yoram Shir, Kam Shojania, Zach Walsh
OBJECTIVE: To assess the efficacy, tolerability, and safety of cannabinoids (phyto- and syntheto-) in the management of rheumatic diseases. METHODS: Multiple databases, including Medline, Embase, and CENTRAL, were searched. Randomized controlled trials with outcomes of pain, sleep, quality of life, tolerability (dropouts due to adverse events), and safety (serious adverse events), with comparison of cannabinoids with any type of control, were included. Study methodology quality was evaluated with the Cochrane risk of bias tool...
May 2016: Arthritis Care & Research
https://www.readbyqxmd.com/read/26307862/what-is-the-meaning-of-small-fiber-neuropathy-in-fibromyalgia
#15
EDITORIAL
Daniel J Clauw
No abstract text is available yet for this article.
November 2015: Pain
https://www.readbyqxmd.com/read/26266995/diagnosing-and-treating-chronic-musculoskeletal-pain-based-on-the-underlying-mechanism-s
#16
REVIEW
Daniel J Clauw
Until recently, most clinicians considered chronic pain to be typically due to ongoing peripheral nociceptive input (i.e., damage or inflammation) in the region of the body where the individual is experiencing pain. Clinicians are generally aware of a few types of pain (e.g., headache and phantom limb pain) where chronic pain is not due to such causes, but most do not realize there is not a single chronic pain state where any radiographic, surgical, or pathological description of peripheral nociceptive damage has been reproducibly shown to be related to the presence or severity of pain...
February 2015: Best Practice & Research. Clinical Rheumatology
https://www.readbyqxmd.com/read/26212052/premature-aging-in-fibromyalgia
#17
REVIEW
Afton L Hassett, Daniel J Clauw, David A Williams
Chronic pain is highly prevalent in older adults, and until recently, was considered to be common but relatively "benign." Mounting evidence, however, suggests that some of the 116 million US adults who suffer from chronic pain are also at an increased risk for developing age-related diseases prematurely, suffering earlier cognitive and physical decline, and experiencing earlier mortality. Given the aging US population and the prevalence of chronic pain along with related healthcare consequences, there is a critical need to better understand the relationship between aging and chronic pain...
2015: Current Aging Science
https://www.readbyqxmd.com/read/25939940/fibromyalgia-and-related-conditions
#18
REVIEW
Daniel J Clauw
Fibromyalgia is the currently preferred term for widespread musculoskeletal pain, typically accompanied by other symptoms such as fatigue, memory problems, and sleep and mood disturbances, for which no alternative cause can be identified. Earlier there was some doubt about whether there was an "organic basis" for these related conditions, but today there is irrefutable evidence from brain imaging and other techniques that this condition has strong biological underpinnings, even though psychological, social, and behavioral factors clearly play prominent roles in some patients...
May 2015: Mayo Clinic Proceedings
https://www.readbyqxmd.com/read/25772388/characteristics-of-fibromyalgia-independently-predict-poorer-long-term-analgesic-outcomes-following-total-knee-and-hip-arthroplasty
#19
Chad M Brummett, Andrew G Urquhart, Afton L Hassett, Alex Tsodikov, Brian R Hallstrom, Nathan I Wood, David A Williams, Daniel J Clauw
OBJECTIVE: While psychosocial factors have been associated with poorer outcomes after knee and hip arthroplasty, we hypothesized that augmented pain perception, as occurs in conditions such as fibromyalgia, may account for decreased responsiveness to primary knee and hip arthroplasty. METHODS: A prospective, observational cohort study was conducted. Preoperative phenotyping was conducted using validated questionnaires to assess pain, function, depression, anxiety, and catastrophizing...
May 2015: Arthritis & Rheumatology
https://www.readbyqxmd.com/read/25768860/fibromyalgia-survey-criteria-are-associated-with-increased-postoperative-opioid-consumption-in-women-undergoing-hysterectomy
#20
Allison M Janda, Sawsan As-Sanie, Baskar Rajala, Alex Tsodikov, Stephanie E Moser, Daniel J Clauw, Chad M Brummett
BACKGROUND: The current study was designed to test the hypothesis that the fibromyalgia survey criteria would be directly associated with increased opioid consumption after hysterectomy even when accounting for other factors previously described as being predictive for acute postoperative pain. METHODS: Two hundred eight adult patients undergoing hysterectomy between October 2011 and December 2013 were phenotyped preoperatively with the use of validated self-reported questionnaires including the 2011 fibromyalgia survey criteria, measures of pain severity and descriptors, psychological measures, preoperative opioid use, and health information...
May 2015: Anesthesiology
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