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https://www.readbyqxmd.com/read/28722609/differences-in-mortality-and-clinical-manifestations-of-dengue-hemorrhagic-fever-in-taiwan-in-different-years-a-comparison-for-cases-in-2014-and-2015-epidemics
#1
Ko Chang, Chung-Hao Huang, Ing-Kit Lee, Po-Liang Lu, Chun-Yu Lin, Tun-Chieh Chen, Ping-Chang Lai, Hsiao-Cheng Hsieh, Hsin-Liang Yu, Chih-Hsing Hung, Meng-Chieh Wu, Yi-Ying Chin, Chun-Chi Huang, Deng-Chyang Wu, Yen-Hsu Chen
People in southern Taiwan experienced two major dengue outbreaks in 2014 and 2015. The mortality and clinical features were very different between these 2 years. Dengue virus serotype 1 (DENV-1) caused epidemic outbreak in 2014 and DENV-2 was predominant in 2015. The characteristics of dengue hemorrhagic fever (DHF) cases in the 2 years was analyzed. We conducted a retrospective chart review to analyze the clinical and laboratory features of 206 adult patients with DHF in southern Taiwan in 2014 and 2015. The mortality rate of DHF cases in 2015 was higher than that of cases in 2014 (38...
June 12, 2017: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/28720770/multivariate-time-series-analysis-on-the-dynamic-relationship-between-class-b-notifiable-diseases-and-gross-domestic-product-gdp-in-china
#2
Tao Zhang, Fei Yin, Ting Zhou, Xing-Yu Zhang, Xiao-Song Li
The surveillance of infectious diseases is of great importance for disease control and prevention, and more attention should be paid to the Class B notifiable diseases in China. Meanwhile, according to the International Monetary Fund (IMF), the annual growth of Chinese gross domestic product (GDP) would decelerate below 7% after many years of soaring. Under such circumstances, this study aimed to answer what will happen to the incidence rates of infectious diseases in China if Chinese GDP growth remained below 7% in the next five years...
December 23, 2016: Scientific Reports
https://www.readbyqxmd.com/read/28720142/comparison-of-serological-assays-to-titrate-hantaan-and-seoul-hantavirus-specific-antibodies
#3
Weihong Li, Shouchun Cao, Quanfu Zhang, Jiandong Li, Shuo Zhang, Wei Wu, Jing Qu, Chuan Li, Mifang Liang, Dexin Li
BACKGROUND: Hantaan and Seoul viruses, in the Hantavirus genus, are known to cause hemorrhagic fever with renal syndrome (HFRS). The plaque reduction neutralization test (PRNT), as conventional neutralization test for hantaviruses, is laborious and time-consuming. Alternatives to PRNT for hantaviruses are required. METHODS: In this study, the methods for Hantaan and Seoul viruses serological typing including microneutralization test (MNT), pseudoparticle neutralization test (PPNT) and immunofluorescence assay based on viral glycoproteins (IFA-GP) were developed and compared with PRNT using a panel of 74 sera including 44 convalescent sera of laboratory confirmed HFRS patients and 30 patients sera of non-hantavirus infection...
July 18, 2017: Virology Journal
https://www.readbyqxmd.com/read/28719259/serosurvey-of-crimean-congo-hemorrhagic-fever-virus-in-cattle-mali-west-africa
#4
Ousmane Maiga, Miriam Andrada Sas, Kyle Rosenke, Badian Kamissoko, Marc Mertens, Nafomon Sogoba, Abdallah Traore, Modibo Sangare, Mamadou Niang, Tom G Schwan, Hamidou Moussa Maiga, Sekou F Traore, Heinz Feldmann, David Safronetz, Martin H Groschup
AbstractCrimean-Congo hemorrhagic fever is a tick-borne disease caused by the arbovirus Crimean-Congo hemorrhagic fever virus (CCHFV, family Bunyaviridae, genus Nairovirus). CCHFV can cause a severe hemorrhagic fever with high-case fatality rates in humans. CCHFV has a wide geographic range and has been described in around 30 countries in the Middle East, Asia, Europe, and Africa including Mali and neighboring countries. To date, little is known about the prevalence rates of CCHFV in Mali. Here, using banked bovine serum samples from across the country, we describe the results of a seroepidemiological study for CCHFV aimed at identifying regions of circulation in Mali...
June 2017: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/28712556/serosurvey-for-crimean-congo-hemorrhagic-fever-virus-infections-in-ruminants-in-katanga-province-democratic-republic-of-the-congo
#5
Miriam A Sas, Marc Mertens, Jean G Kadiat, Isolde Schuster, Célestin P S Pongombo, Alois G K Maloba, Martin H Groschup
Crimean-Congo hemorrhagic fever virus (CCHFV) has been detected in many African countries. Unfortunately, little is known about the current CCHFV situation in most of those countries including the Democratic Republic of the Congo (DRC). In over 50 years, three human CCHF cases have been detected in DRC but no seroepidemiological investigation was performed so far. To determine the prevalence of CCHFV-specific antibodies we tested 838 serum samples of cattle, goat and sheep from the southern province Katanga, DRC...
July 3, 2017: Ticks and Tick-borne Diseases
https://www.readbyqxmd.com/read/28710747/phase-i-study-of-chimeric-antigen-receptor-modified-t-cells-in-treating-her2-positive-advanced-biliary-tract-cancers-and-pancreatic-cancers
#6
Kaichao Feng, Yang Liu, Yelei Guo, Jingdan Qiu, Zhiqiang Wu, Hanren Dai, Qingming Yang, Yao Wang, Weidong Han
This phase I clinical trial (NCT01935843) is to evaluate the safety, feasibility, and activity of chimeric antigen receptor-engineered T cell (CART) immunotherapy targeting human epidermal growth factor receptor 2 (HER2) in patients with advanced biliary tract cancers (BTCs) and pancreatic cancers (PCs). Eligible patients with HER2-positive (>50%) BTCs and PCs were enrolled in the trial. Well cultured CART-HER2 cells were infused following the conditioning treatment composed of nab-paclitaxel (100-200 mg/m(2)) and cyclophosphamide (15-35 mg/kg)...
July 14, 2017: Protein & Cell
https://www.readbyqxmd.com/read/28710265/francisella-like-endosymbionts-and-rickettsia-species-in-local-and-imported-hyalomma-ticks
#7
Tal Azagi, Eyal Klement, Gidon Perlman, Yaniv Lustig, Kosta Y Mumcuoglu, Dmitry Apanaskevich, Yuval Gottlieb
Hyalomma ticks (Acari: Ixodidae) are hosts for Francisella like endosymbionts (FLE) and may serve as vectors of zoonotic disease agents. This study was aimed to provide initial characterization of the interaction between Hyalomma and FLE and to determine the prevalence of pathogenic Rickettsia in these ticks. Hyalomma marginatum, H. rufipes, H. dromedarii, H. aegyptium and H. excavatum ticks, identified morphologically and molecularly, were collected from different hosts and locations, representing the genus distribution in Israel, as well as from migratory birds...
July 14, 2017: Applied and Environmental Microbiology
https://www.readbyqxmd.com/read/28709136/tetracyclines-as-a-potential-antiviral-therapy-against-crimean-congo-hemorrhagic-fever-virus-docking-and-molecular-dynamic-studies
#8
Amirhossein Sharifi, Arash Amanlou, Faezeh Moosavi-Movahedi, Sahand Golestanian, Massoud Amanlou
Crimean-Congo Hemorrhagic Fever Virus (CCHFV) is one of the deadliest human diseases with mortality rate near 50%. Special attention should be paid to this virus since there is no approved treatment for it. On the other hand, the recent outbreak of Ebola virus which is a member of hemorrhagic fever viruses shows this group of viruses can be extremely dangerous. Previous studies have indicated that nucleoprotein of CCHFV, a pivotal protein in virus replication, is an appropriate target for antiviral drug development...
July 1, 2017: Computational Biology and Chemistry
https://www.readbyqxmd.com/read/28705183/generic-amplification-and-next-generation-sequencing-reveal-crimean-congo-hemorrhagic-fever-virus-ap92-like-strain-and-distinct-tick-phleboviruses-in-anatolia-turkey
#9
Ender Dinçer, Annika Brinkmann, Olcay Hekimoğlu, Sabri Hacıoğlu, Katalin Földes, Zeynep Karapınar, Pelin Fatoş Polat, Bekir Oğuz, Özlem Orunç Kılınç, Peter Hagedorn, Nurdan Özer, Aykut Özkul, Andreas Nitsche, Koray Ergünay
BACKGROUND: Ticks are involved with the transmission of several viruses with significant health impact. As incidences of tick-borne viral infections are rising, several novel and divergent tick- associated viruses have recently been documented to exist and circulate worldwide. This study was performed as a cross-sectional screening for all major tick-borne viruses in several regions in Turkey. Next generation sequencing (NGS) was employed for virus genome characterization. Ticks were collected at 43 locations in 14 provinces across the Aegean, Thrace, Mediterranean, Black Sea, central, southern and eastern regions of Anatolia during 2014-2016...
July 14, 2017: Parasites & Vectors
https://www.readbyqxmd.com/read/28702053/etiology-of-hypopituitarism-in-adult-patients-the-experience-of-a-single-center-database-in-the-serbian-population
#10
M Doknić, S Pekić, D Miljić, I Soldatović, V Popović, M Stojanović, M Petakov
There are only a few published studies related to the population-based etiology of hypopituitarism. New risks for developing hypopituitarism have been recognized in the last 10 years. Aim. To present data regarding the etiology of hypopituitarism collected in a tertiary center over the last decade. This is a cross-sectional database study. Patients and Methods. We included 512 patients (pts) with hypopituitarism, with a mean age of 45.9 ± 1.7 yrs (range: 18-82; male: 57.9%). Results. Nonfunctional pituitary adenomas were presented in 205 pts (40...
2017: International Journal of Endocrinology
https://www.readbyqxmd.com/read/28700846/crimean-congo-hemorrhagic-fever-in-spain-new-arrival-or-silent-resident
#11
Jessica R Spengler, Dennis A Bente
New England Journal of Medicine, Volume 377, Issue 2, Page 106-108, July 2017.
July 13, 2017: New England Journal of Medicine
https://www.readbyqxmd.com/read/28700843/autochthonous-crimean-congo-hemorrhagic-fever-in-spain
#12
Anabel Negredo, Fernando de la Calle-Prieto, Eduardo Palencia-Herrejón, Marta Mora-Rillo, Jenaro Astray-Mochales, María P Sánchez-Seco, Esther Bermejo Lopez, Javier Menárguez, Ana Fernández-Cruz, Beatriz Sánchez-Artola, Elena Keough-Delgado, Eva Ramírez de Arellano, Fátima Lasala, Jakob Milla, Jose L Fraile, Maria Ordobás Gavín, Amalia Martinez de la Gándara, Lorenzo López Perez, Domingo Diaz-Diaz, M Aurora López-García, Pilar Delgado-Jimenez, Alejandro Martín-Quirós, Elena Trigo, Juan C Figueira, Jesús Manzanares, Elena Rodriguez-Baena, Luis Garcia-Comas, Olaia Rodríguez-Fraga, Nicolás García-Arenzana, Maria V Fernández-Díaz, Victor M Cornejo, Petra Emmerich, Jonas Schmidt-Chanasit, Jose R Arribas
Crimean-Congo hemorrhagic fever (CCHF) is a widely distributed, viral, tickborne disease. In Europe, cases have been reported only in the southeastern part of the continent. We report two autochthonous cases in Spain. The index patient acquired the disease through a tick bite in the province of Ávila - 300 km away from the province of Cáceres, where viral RNA from ticks was amplified in 2010. The second patient was a nurse who became infected while caring for the index patient. Both were infected with the African 3 lineage of this virus...
July 13, 2017: New England Journal of Medicine
https://www.readbyqxmd.com/read/28693518/the-third-delay-understanding-waiting-time-for-obstetric-referrals-at-a-large-regional-hospital-in-ghana
#13
David M Goodman, Emmanuel K Srofenyoh, Adeyemi J Olufolabi, Sung Min Kim, Medge D Owen
BACKGROUND: Delay in receiving care significantly contributes to maternal morbidity and mortality. Much has been studied about reducing delays prior to arrival to referral facilities, but the delays incurred upon arrival to the hospital have not been described in many low- and middle-income countries. METHODS: We report on the obstetric referral process at Ridge Regional Hospital, Accra, Ghana, the largest referral hospital in the Ghana Health System. This study uses data from a prospectively-collected cohort of 1082 women presenting with pregnancy complications over a 10-week period...
July 11, 2017: BMC Pregnancy and Childbirth
https://www.readbyqxmd.com/read/28686617/dengue-virus-specific-igy-provides-protection-following-lethal-dengue-virus-challenge-and-is-neutralizing-in-the-absence-of-inducing-antibody-dependent-enhancement
#14
Ashley L Fink, Katherine L Williams, Eva Harris, Travis D Alvine, Thomas Henderson, James Schiltz, Matthew L Nilles, David S Bradley
Dengue hemorrhagic fever (DHF) and dengue shock syndrome (DSS) are severe disease manifestations that can occur following sequential infection with different dengue virus serotypes (DENV1-4). At present, there are no licensed therapies to treat DENV-induced disease. DHF and DSS are thought to be mediated by serotype cross-reactive antibodies that facilitate antibody-dependent enhancement (ADE) by binding to viral antigens and then Fcγ receptors (FcγR) on target myeloid cells. Using genetically engineered DENV-specific antibodies, it has been shown that the interaction between the Fc portion of serotype cross-reactive antibodies and FcγR is required to induce ADE...
July 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28685549/analysis-of-hemorrhagic-fever-with-renal-syndrome-and-its-pathogenic-gene-sequence-based-on-geographic-information-system
#15
Z Tang, X J Xu, X J He, Z S Liang, W B Liang, Y Li, K Gao
This study analyzed the temporal-spatial distribution characteristics, epidemiological characteristics and gene sequences of hemorrhagic fever with renal syndrome (HFRS) in Guangxi, with the intention of providing a theoretical and technical support for the prevention of HFRS. A map of the incidence of HFRS of different cities in Guangxi was drawn up using the Geographic Information System (GIS) to investigate the epidemiological characteristics and infection source of HFRS between 2013 and 2016. Guangxi has a low incidence of HFRS, and autumn and winter are the main high-incidence seasons...
April 2017: Journal of Biological Regulators and Homeostatic Agents
https://www.readbyqxmd.com/read/28680856/sertoli-cells-are-susceptible-to-zikv-infection-in-mouse-testis
#16
Zi-Yang Sheng, Na Gao, Zhao-Yang Wang, Xiao-Yun Cui, De-Shan Zhou, Dong-Ying Fan, Hui Chen, Pei-Gang Wang, Jing An
Flaviviruses including Dengue virus (DENV), Yellow fever virus (YFV), West Nile virus (WNV), and Japanese encephalitis virus (JEV) are global health problems that caused several serious diseases such as fever, hemorrhagic fever, and encephalitis in the past century. Recently, Zika virus (ZIKV) which spreads from Asia to American and causes millions of infections emerges as a new dangerous member of the genus of Flavivirus. Unlike other well-known flaviviruses, ZIKV can be transmitted sexually and infect testes in murine models...
2017: Frontiers in Cellular and Infection Microbiology
https://www.readbyqxmd.com/read/28680728/intradural-extramedullary-cavernous-malformation-with-extensive-superficial-siderosis-of-the-neuraxis-case-report-and-review-of-literature
#17
Pedram Golnari, Sameer A Ansari, Ali Shaibani, Michael C Hurley, Matthew B Potts, Missia E Kohler, Patrick A Sugrue, Babak S Jahromi
BACKGROUND: Spinal cavernous malformations usually affect the vertebral bodies and are seldom intradural. Here, we report a rare spinal intradural-extramedullary cavernous malformation associated with extensive superficial siderosis along the neuraxis in a patient with radicular complaints. CASE DESCRIPTION: A 60-year-old male presented with subacute headaches, intermittent fever, and acute back and radicular leg pain for 1-2 weeks. Magnetic resonance imaging revealed an intradural-extramedullary lesion just below the conus medullaris (at the L2 level)...
2017: Surgical Neurology International
https://www.readbyqxmd.com/read/28680057/an-attenuated-machupo-virus-with-a-disrupted-l-segment-intergenic-region-protects-guinea-pigs-against-lethal-guanarito-virus-infection
#18
Joseph W Golden, Brett Beitzel, Jason T Ladner, Eric M Mucker, Steven A Kwilas, Gustavo Palacios, Jay W Hooper
Machupo virus (MACV) is a New World (NW) arenavirus and causative agent of Bolivian hemorrhagic fever (HF). Here, we identified a variant of MACV strain Carvallo termed Car(91) that was attenuated in guinea pigs. Infection of guinea pigs with an earlier passage of Carvallo, termed Car(68), resulted in a lethal disease with a 63% mortality rate. Sequencing analysis revealed that compared to Car(68), Car(91) had a 35 nucleotide (nt) deletion and a point mutation within the L-segment intergenic region (IGR), and three silent changes in the polymerase gene that did not impact amino acid coding...
July 5, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28679761/the-host-e3-ubiquitin-ligase-trim6-ubiquitinates-the-ebola-virus-vp35-protein-and-promotes-virus-replication
#19
Preeti Bharaj, Colm Atkins, Priya Luthra, Maria Isabel Giraldo, Brian E Dawes, Lisa Miorin, Jeffrey R Johnson, Nevan J Krogan, Christopher F Basler, Alexander N Freiberg, Ricardo Rajsbaum
Ebola virus (EBOV), a member of the Filoviridae family, is a highly pathogenic virus that causes severe hemorrhagic fever in humans and is responsible for epidemics throughout sub-Saharan, central and West Africa. The EBOV genome encodes for VP35, an important viral protein involved in virus replication by acting as an essential cofactor of the viral polymerase as well as a potent antagonist of the host antiviral type-I interferon (IFN-I) system. By using mass spectrometry analysis and co-immunoprecipitation assays, we show here that VP35 is ubiquitinated on lysine 309 (K309), a residue located on its IFN antagonist domain...
July 5, 2017: Journal of Virology
https://www.readbyqxmd.com/read/28679759/mutational-analysis-of-lassa-virus-glycoprotein-highlights-regions-required-for-alpha-dystroglycan-utilization
#20
Marissa Acciani, Jacob T Alston, Guohui Zhao, Hayley Reynolds, Afroze M Ali, Brian Xu, Melinda A Brindley
Lassa virus (LASV) is an enveloped RNA virus endemic to West Africa and responsible for severe cases of hemorrhagic fever. Virus entry is mediated by the glycoprotein complex consisting of a stable signal peptide, a receptor-binding subunit GP1, and a viral-host membrane fusion subunit GP2. Several cellular receptors can interact with the GP1 subunit and mediate viral entry, including alpha-dystroglycan (αDG) and lysosomal associated membrane protein 1 (LAMP1). In order to define the regions within GP1 that interact with the cellular receptors, we implemented insertional mutagenesis, carbohydrate shielding, and alanine scanning mutagenesis...
July 5, 2017: Journal of Virology
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