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metastasic cancer gastric patients: can we improve

Jun-Peng Lin, Jian-Xian Lin, Long-Long Cao, Chao-Hui Zheng, Ping Li, Jian-Wei Xie, Jia-Bin Wang, Jun Lu, Qi-Yue Chen, Mi Lin, Ru-Hong Tu, Chang-Ming Huang
OBJECTIVES: To evaluate the predictive value of the preoperative lymphocyte-to-monocyte ratio (LMR) for the prognosis of patients with gastric cancer (GC) after radical-intent surgery. METHODS: We retrospectively analyzed 1,810 patients who underwent radical-intent gastrectomy for primary GC from December 2008 to December 2013. X-tile software was used to identify the optimal value for blood LMR. Nomograms were developed to predict overall survival (OS) and recurrence-free survival (RFS) after surgery...
April 12, 2017: Oncotarget
Yu Wang, Liping Wang, Hong Chen, Yang Xu, Xiaoyu Zheng, Guonian Wang
BACKGROUND: Epidural use can provide a better short-term outcome and protect patients from the postoperative development of tumour recurrence and metastases. In this study, we sought to assess the effects of intra- and postoperative anaesthesia and analgesia choice on outcome after gastric cancer resection, searched for evidence of interaction between intra-and postoperative epidural use and outcomes of gastric cancer patients. METHODS: Four thousand two hundred and eighteen cases of gastric cancer were identified from the Records of Hospital Patients...
March 30, 2017: Oncotarget
Kohei Shitara, Atsuo Takashima, Kazumasa Fujitani, Keisuke Koeda, Hiroki Hara, Norisuke Nakayama, Shuichi Hironaka, Kazuhiro Nishikawa, Yoichi Makari, Kenji Amagai, Shinya Ueda, Kazuhiro Yoshida, Hideki Shimodaira, Tomohiro Nishina, Masahiro Tsuda, Yukinori Kurokawa, Takao Tamura, Yasutsuna Sasaki, Satoshi Morita, Wasaburo Koizumi
BACKGROUND: Weekly administration of solvent-based paclitaxel is one of the standard second-line chemotherapy regimens for advanced gastric cancer. Nanoparticle albumin-bound paclitaxel (nab-paclitaxel) was developed to improve the solubility of paclitaxel and does not need premedication to avoid infusion-related reactions associated with solvent-based paclitaxel. Additionally, higher doses of nab-paclitaxel can be administered over a shorter infusion time and at higher drug concentrations compared with solvent-based paclitaxel...
April 2017: Lancet. Gastroenterology & Hepatology
Yasuhiro Tamaki
The one-step nucleic acid amplification (OSNA) assay was initially developed for the intraoperative assessment of sentinel lymph node metastases in breast cancer. This assay measures cytokeratin 19 (CK19) mRNA copy number and is widely used in hospitals. The results of the IBCSG 23-01, ACOSOG Z0011, and AMAROS trials demonstrated that no further axillary dissection is required for patients with sentinel lymph nodes that tested positive for cancer, which has led to a decreasing trend in the need for intraoperative assessment of lymph nodes...
February 2017: International Journal of Clinical Oncology
T Jínek, L Adamčík, M Duda, M Škrovina
INTRODUCTION: Gastric stump cancer accounts for 14% of all gastric carcinomas. Originally this term included patients who previously underwent surgery due to peptic ulcer disease but today gastric stump cancer also includes patients diagnosed some time after primary gastric resection due to gastric cancer. The incidence is increasing. Gastric stump cancer is associated with poor prognosis and its reported resecability is around 40%. METHODS: We retrospectively analyzed the data of 7 patients with a preoperatively histologically confirmed stump cancer who had been operated at the Department of Surgery at Nový Jičín Hospital during 2006-2014...
September 2015: Rozhledy V Chirurgii: Měsíčník Československé Chirurgické Společnosti
Maurizio Cardi, Paolo Sammartino, Valentina Mingarelli, Simone Sibio, Fabio Accarpio, Daniele Biacchi, Daniela Musio, Bianca Sollazzo, Angelo Di Giorgio
BACKGROUND: Peritoneal metastasis (PM) is considered a terminal and incurable disease. In the last 30 years, cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) radically changed the therapeutic approach for these patients and is regarded as the standard of care for pseudomyxoma peritonei from appendiceal cancer and peritoneal mesotheliomas. Improved survival has also been reported in treating PM from ovarian, gastric, and colorectal cancers. However, PM often seriously complicates the clinical course of patients with other primary digestive and non-digestive cancers...
2015: World Journal of Surgical Oncology
Sheng Yang, Rui Feng, Zhang-Chi Pan, Tao Jiang, Qian Xu, Qiang Chen
We aimed to evaluate the effectiveness and safety of intravenous (IV) plus intraperitoneal (IP) chemotherapy compared to intravenous (IV) chemotherapy alone for patients with gastric cancer. Electronic databases were searched up to June 2013. Two authors independently selected studies, extracted data and assessed the quality of included studies. The GRADE System was adopted to rate the level of evidence. Of 392 citations, five RCTs involving 1072 patients were included. Overall, a significant improvement in in one- and three- and five-year survival rate was observed in the IV plus IP chemotherapy group (3 RCTs, n = 360, RR = 1...
2015: Scientific Reports
Takatsugu Yamamoto, Toru Miyazaki, Yukiko Kurashima, Kazunori Ohata, Masato Okawa, Shogo Tanaka, Takahiro Uenishi, Koichi Ohno
An 80-year-old Japanese woman with chronic renal failure was diagnosed with gastric cancer and 2 primary colon cancers. The colon cancers were treated with laparoscopic colectomy, but the gastric cancer metastasized to the liver with inoperable dissemination. After operative treatment of the colon cancers, 1 year of combination chemotherapy consisting of tegafur/gimeracil/oteracil (TS-1®) and nab-PTX was administered to treat the advanced gastric cancer. Tegafur is a well-known prodrug of 5-FU. Serum densitometry of 5-FU was performed to determine the correct dose of TS-1®...
June 2015: Gan to Kagaku Ryoho. Cancer & Chemotherapy
Sevim Turanli, Can Atalay, Ugur Berberoglu, Kaptan Gulben
OBJECTIVE: Gastric cancer is often diagnosed at an advanced stage and surgery alone cannot guarantee satisfactory results. Both chemoradiotherapy (CRT) and chemotherapy (CT) are used in postoperative therapy. However, it is controversial whether CRT or CT is better after D2 lymphadenectomy. In this study we investigated the efficacy of adjuvant CRT versus CT in stage III gastric cancer patients treated with R0 gastrectomy and D2 lymph node dissection. PATIENTS AND METHODS: Data from 92 patients diagnosed with gastric adenocarcinoma and treated with surgery followed by adjuvant treatment were retrospectively analyzed...
April 2015: Journal of Cancer Research and Therapeutics
Jeong Won Lee, Jae-Hoon Lee, Arthur Cho, Mijin Yun, Jong Doo Lee, Young Tae Kim, Won Jun Kang
PURPOSE: This study aimed to evaluate the diagnostic accuracy of contrast-enhanced FDG PET/CT for unexpected ovarian lesions in patients with nongynecologic cancers. PATIENTS AND METHODS: The present retrospective study was approved by the hospital institutional review board. We enrolled 72 nongynecologic cancer patients (33 colorectal cancer, 20 breast cancer, and 19 gastric cancer) who showed unexpected ovarian lesions on contrast-enhanced FDG PET/CT and subsequently underwent surgical resection of the ovarian lesions...
February 2015: Clinical Nuclear Medicine
Kentaro Kishi, Yoshiyuki Fujiwara, Masahiko Yano, Masaaki Motoori, Keijiro Sugimura, Masayuki Ohue, Shingo Noura, Shigeru Marubashi, Hidenori Takahashi, Masato Sakon
OBJECTS: Recently, we reported that diagnostic laparoscopy with photodynamic diagnosis using oral 5-aminolevulinic acid (ALA-PDD) is a promising tool for diagnosing early peritoneal metastases in gastric cancer. The present study evaluated the usefulness of adding ALA-PDD to conventional diagnostic laparoscopy and assessed the association of the ALA-PDD results with peritoneal fluid cytology and molecular diagnostic testing. METHODS: Diagnostic laparoscopy using sequential white light (WL) and ALA-PDD observations was performed in 52 advanced gastric cancer patients, and the sensitivity of ALA-PDD for detecting peritoneal disease was compared to WL...
2014: Oncology
Li Xiao, Yun-Peng Liu, Chuan-Xing Xiao, Jian-Lin Ren, Bayasi Guleng
BACKGROUND: As a secreted protein, serum trefoil factor 3 (TFF3) has been reported to be a biomarker of several malignancies. We further investigated whether TFF3 can be applied as a biomarker for and predictor of responses to chemotherapy in gastrointestinal cancer. METHODS: Serum and urine samples were collected from 90 patients with gastric cancer, 128 patients with colorectal cancer and 91 healthy individuals. Serum and urine TFF3 levels were measured using an ELISA...
2014: BMC Clinical Pathology
R Karakoyun, E Demirci, M Karakoyun, B Karakaş, U Gündüz, Z Sener, S Gülenay, B Erol, E Sağtaş
AIM: The aim of this study was to evaluate the reliability of thin-slice hydro-multidetector row computed tomography (MDCT) in assessing resectability and lymph node staging of gastric cancer. METHODS: Sixty-one patients (37 males, 24 females; mean age 61 years) with gastric cancer, and whose surgery was planned, underwent preoperative abdominopelvic hydro-MDCT at slice thickness of 5 mm. We evaluated the tumor stage, depth of tumor invasion into the gastric wall, metastasis of lymph node, and presence/absence of distant metastases on the CT images produced with multiplanar reconstruction (MPR) and hydro-CT technique...
June 2014: Minerva Chirurgica
Joji Kitayama, Hironori Ishigami, Hironori Yamaguchi, Shigenobu Emoto, Toshiaki Watanabe
BACKGROUND: Intraperitoneal administration of paclitaxel (PTX) can elicit a marked clinical response in peritoneal metastases of gastric cancer. METHODS: In this study, we retrospectively analyzed the clinical outcome of 17 patients who underwent R0 resection with D2 dissection for advanced gastric cancer with macroscopic serosal exposure and received intraperitoneal PTX as adjuvant therapy. RESULTS: A pathological study revealed that the depth of invasion of the primary tumor was pT4a or pT4b in 10 cases, and that the pN stage was more than pN2 in 8 cases...
January 2014: Case Reports in Oncology
Adriana Bosolino, Amerys Cravero, Raquel Ratto
Metastases to the stomach from an extra-digestive neoplasm are an unusual event, identified in less than 2% of cancer patients at autopsy (between 1.7% to 5%). The stomach may be involved by hematogenous spread from a distant primary tumor (most commonly lung, breast and melanoma). Tumors of neighboring organs, such as esophagus, pancreas and gallbladder, may reach the stomach by continuity or by lymphatic-hematogenous spread. Endoscopic routine studies with biopsies have improved the diagnosis of this pathology...
December 2013: Acta Gastroenterologica Latinoamericana
Clara L Sampieri, Kenneth León-Córdoba, Jos Maria Remes-Troche
Gastric cancer is a complex disease that involves a range of biological individuals and tumors with histopathological features. The pathogenesis of this disease is multi-factorial and includes the interaction of genetic predisposition with environmental factors. Gastric cancer is normally diagnosed in advanced stages where there are few alternatives to offer and the prognosis is difficult to establish. Metastasis is the leading cause of cancer deaths. Identification of key genes and signaling pathways involved in metastasis and recurrence could predict these events and thereby identify therapeutic targets...
July 2013: Journal of Cancer Research and Therapeutics
Yukinori Kurokawa, Taro Shibata, Mitsuru Sasako, Takeshi Sano, Akira Tsuburaya, Yoshiaki Iwasaki, Haruhiko Fukuda
BACKGROUND: Neoadjuvant chemotherapy may improve outcomes in gastric cancer. Tumor responses can be evaluated with RECIST, Japanese Classification of Gastric Carcinoma (JCGC), and histological criteria. These approaches have not yet been compared. METHODS: We analyzed two phase II trials of neoadjuvant chemotherapy using S-1 plus cisplatin. JCOG0210 included patients with linitis plastica and large ulcero-invasive tumors, whereas JCOG0405 comprised those with para-aortic or bulky lymph node metastases...
2014: Gastric Cancer
J Simša, M Levý, J Vedralová
INTRODUCTION: Gastric cancer, despite of its decreasing incidence, remains a serious medical problem. Many patients see a specialist as late as in the IVth stage of the disease with peritoneal seedings or liver metastases. Liver resection for gastric cancer metastases remains to be a controversial issue. MATERIAL AND METHODS: The aim of this study is to present, through our case report and literature review, the current opinions on liver resections for metastatic gastric cancer...
August 2012: Rozhledy V Chirurgii: Měsíčník Československé Chirurgické Společnosti
Nipun B Merchant, Alexander A Parikh, David A Kooby
Despite the relatively slow start of laparoscopic pancreatectomy relative to other laparoscopic resections, an increasing number of these procedures are being performed around the world. Operations that were once considered impossible to perform laparoscopically, such as pancreaticoduodenectomy and central pancreatectomy are gaining momentum. Technology continues to improve, as does surgical experience and prowess. There are both enough experience and data (though retrospective) to confirm that LDP with or without spleen preservation appears to be a safe treatment for benign or noninvasive lesions of the pancreas...
2009: Advances in Surgery
Gábor Cserni, Tibor Vágó, Norbert Török, Zoltán Gaál, Tamás Velkei, Péter Serényi, Katalin Göczo, Magdolna Tusa, Katalin Kovács, Miklós Szucs
INTRODUCTION: Carcinomatous meningitis is a serious complication of advanced stage solid tumours, which may become more common with improved survival. CASE REPORTS: A 53-year-old woman with a recent history of breast cancer (pT2pN2M0) had been treated by mastectomy and adjuvant chemotherapy and radiotherapy. She presented with weakness, diplopia and vertigo raising the possibility of vertebrobasilar ischaemia or an intracranial mass. In another patient, a 62-year-old man with hypertension, a stenotic common bile duct had been diagnosed when examined for abdominal complaints...
October 2007: Lege Artis Medicinae: új Magyar Orvosi Hírmondó
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