Ying-Ao Liu, Yuanhao Liu, Jiajuan Tu, Yihong Shi, Junyi Pang, Qi Huang, Xun Wang, Zhixiang Lin, Yupei Zhao, Wenze Wang, Junya Peng, Wenming Wu
The diagnosis of solid pseudopapillary neoplasm of the pancreas (SPN) can be challenging due to potential confusion with other pancreatic neoplasms, particularly pancreatic neuroendocrine tumors (NETs), using current pathological diagnostic markers. We conducted a comprehensive analysis of bulk RNA sequencing data from SPNs, NETs, and normal pancreas, followed by experimental validation. This analysis revealed an increased accumulation of peroxisomes in SPNs. Moreover, we observed significant upregulation of the peroxisome marker ABCD1 in both primary and metastatic SPN samples compared with normal pancreas and NETs...
April 3, 2024: American Journal of Surgical Pathology