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https://www.readbyqxmd.com/read/29736148/the-pre-treatment-characteristics-and-evaluation-of-the-effects-of-recombinant-human-growth-hormone-therapy-in-children-with-growth-hormone-deficiency-and-celiac-disease-or-inflammatory-bowel-disease
#1
Ewelina Witkowska-Sędek, Dominika Labochka, Anna Majcher, Beata Pyrżak
The aim of the study: was to investigate the coincidence of growth hormone deficiency (GHD) and celiac disease (CD) or inflammatory bowel disease (IBD) in patients referred for short stature, and to evaluate the baseline anthropometric parameters and the effectiveness of recombinant human growth hormone (rhGH) therapy in the first year in those patients (GHD+CD/IBD subgroup) in comparison to patients with GHD without CD or IBD (GHD-CD/IBD subgroup). Material and methods: The study was retrospective and included 2196 short patients (height SDS [Standard Deviation Score] ≤ -1...
2018: Central-European Journal of Immunology
https://www.readbyqxmd.com/read/29721322/direct-and-cytokine-mediated-effects-of-albumin-fused-growth-hormone-tv-1106-on-cyp-enzyme-expression-in-human-hepatocytes-in-vitro
#2
Maciej Czerwiński, Immaculate Amunom, Victor Piryatinsky, Hussein Hallak, Yousif Sahly, Oren Bar-Ilan, Paul Bolliger, Merav Bassan
Some biologics can modulate cytokines that may lead to changes in expression of drug-metabolizing enzymes and cause drug-drug interactions (DDI). DDI potential of TV-1106-an albumin-fused growth hormone (GH)-was investigated. In this study, human blood was exposed to recombinant human growth hormone (rhGH) or TV-1106, followed by isolation of the plasma and its application to human hepatocytes. While the treatment of blood with rhGH increased multiple cytokines, treatment of blood with TV-1106 had no effect on any of the nine cytokines tested...
June 2018: Pharmacology Research & Perspectives
https://www.readbyqxmd.com/read/29693323/single-step-recombinant-human-growth-hormone-rhgh-purification-from-milk-by-peptide-affinity-chromatography
#3
Soledad L Saavedra, María C Martínez Ceron, Silvana L Giudicessi, Guillermina Forno, María Belén Bosco, Mariela M Marani, Rosa Erra-Balsells, Fernando Albericio, Osvaldo Cascone, Silvia A Camperi
Recombinant human growth hormone (rhGH) is used for the treatment of several pathologies, most of them related to growth. Although different expression systems can be used for its production, the milk from transgenic cows is one of the most interesting due to the high rhGH level achieved (5 g/L). We have designed and synthesized short peptides (9 or 10 amino acid long) using Fmoc chemistry and studied its ability to purify rhGH from milk once immobilized on an agarose support. Using spiked milk with the hormone as a sample, rhGH was purified with 88% yield and 92% purity in a single step with a fold purification of 4...
April 25, 2018: Biotechnology Progress
https://www.readbyqxmd.com/read/29688888/body-composition-and-metabolic-health-of-young-male-adults-with-childhood-onset-multiple-pituitary-hormone-deficiency-after-cessation-of-growth-hormone-treatment
#4
Hongbo Yang, Linjie Wang, Xiaonan Qiu, Kemin Yan, Fengying Gong, Huijuan Zhu, Hui Pan
BACKGROUND: Recombinant human growth hormone (rhGH) replacement therapy is usually stopped after linear growth completion in patients with growth hormone deficiency. In patients with multiple pituitary hormone deficiency (MPHD), the long-term effects of discontinuation of rhGH replacement are unknown. METHODS: In this study, the anthropometric and metabolic parameters of 24 male patients with adult growth hormone deficiency (AGHD) due to MPHD in childhood after cessation of rhGH therapy for a mean of 7...
April 24, 2018: Journal of Pediatric Endocrinology & Metabolism: JPEM
https://www.readbyqxmd.com/read/29649340/the-relationship-between-alkaline-phosphatase-and-bone-alkaline-phosphatase-activity-and-the-growth-hormone-insulin-like-growth-factor-1-axis-and-vitamin-d-status-in-children-with-growth-hormone-deficiency
#5
Ewelina Witkowska-Sędek, Anna Stelmaszczyk-Emmel, Anna Majcher, Urszula Demkow, Beata Pyrżak
The relationships between bone turnover, the growth hormone/insulin-like growth factor-1 (GH/IGF-1) axis and vitamin D are complex, but still not fully explained. The GH/IGF-1 axis and vitamin D can mutually modulate each other's metabolism and influence the activation of cell proliferation, maturation, and mineralization as well as bone resorption. The aim of this study was to evaluate the reciprocal associations between bone formation markers [alkaline phosphatase (ALP), bone alkaline phosphatase (BALP)], the GH/IGF-1 axis and 25-hydroxyvitamin D [25(OH)D] in children with growth hormone deficiency at baseline and during recombinant human growth hormone (rhGH) therapy...
April 13, 2018: Acta Biochimica Polonica
https://www.readbyqxmd.com/read/29615058/effects-of-recombinant-human-growth-hormone-administration-on-cardiovascular-risk-factors-in-obese-children-with-relative-growth-hormone-deficiency
#6
Shuang Liang, Jiang Xue, Guimei Li
BACKGROUND: Based on the sample of obese children with relative growth hormone deficiency (GHD), the objective of our study was to determine the effects of rhGH treatment on cardiovascular risk factors, including body mass index (BMI), lipid levels and glucose metabolism index. METHODS: A total of 43 obese children with relative GHD were included in our final analysis. The obese subjects were divided into two groups: recombinant human growth hormone (rhGH) treatment group and untreated control group...
April 3, 2018: Lipids in Health and Disease
https://www.readbyqxmd.com/read/29609449/design-of-the-long-term-observational-cohort-study-with-recombinant-human-growth-hormone-in-korean-children-lg-growth-study
#7
Sochung Chung, Jae-Ho Yoo, Jin Ho Choi, Young-Jun Rhie, Hyun-Wook Chae, Jae Hyun Kim, Il Tae Hwang, Choong Ho Shin, Eun Young Kim, Kee-Hyoung Lee
PURPOSE: Regarding recombinant human growth hormone (rhGH) use in the pediatric population, no long-term follow-up data are available for Korean patients. To fill in the gap of knowledge, a registry study (LG Growth Study) was initiated to assess the safety and effectiveness of four types of rhGH products in real-life settings. METHODS: A total of 4,000 children will be registered and prospectively followed up at 6-month intervals until 2 years after epiphyseal closure to collect data on treatment and adverse events, with primary interest in malignancies and growth outcomes...
March 2018: Annals of Pediatric Endocrinology & Metabolism
https://www.readbyqxmd.com/read/29581156/height-outcome-of-the-recombinant-human-growth-hormone-treatment-in-turner-syndrome-a-meta-analysis
#8
Ping Li, Fei Cheng, Lei Xiu
OBJECTIVE: This study sought to determine the effect of the recombinant human growth hormone (rhGH) treatment of Turner syndrome (TS) on height outcome. Methods:We searched in MEDLINE, EMBASE and Cochrane Central Register of Controlled Trials and Cochrane Database of Systematic Reviews. A literature search identified 640 records. After screening and full-text assessment, 11 records were included in the systematic review. Methodological quality was assessed using the Cochrane Risk of Bias tool...
March 26, 2018: Endocrine Connections
https://www.readbyqxmd.com/read/29572496/optical-detection-of-degraded-therapeutic-proteins
#9
William F Herrington, Gajendra P Singh, Di Wu, Paul W Barone, William Hancock, Rajeev J Ram
The quality of therapeutic proteins such as hormones, subunit and conjugate vaccines, and antibodies is critical to the safety and efficacy of modern medicine. Identifying malformed proteins at the point-of-care can prevent adverse immune reactions in patients; this is of special concern when there is an insecure supply chain resulting in the delivery of degraded, or even counterfeit, drug product. Identification of degraded protein, for example human growth hormone, is demonstrated by applying automated anomaly detection algorithms...
March 23, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29461609/the-effects-of-recombinant-human-growth-hormone-rhgh-on-survival-of-slender-narrow-pedicle-flap-and-expressions-of-vascular-endothelial-growth-factor-vegf-and-classification-determinant-34-cd34
#10
W Sun, W-Y Yu, D-J Yu, T-L Zhao, L-J Wu, W-Y Han
OBJECTIVE: To explore the effects of recombinant human growth hormone (rHGH) on the survival of the mouse slender narrow pedicle flap and the expressions of vascular endothelial growth factor (VEGF) and classification determinant 34 (CD34). MATERIALS AND METHODS: A total of 20 BALB/c mice were randomly divided into the experimental group (n=10) and control group (n=10). The flaps were transplanted for mice in two groups respectively. 6 h after the operation, the mice in the experimental group were administrated with rHGH via local subcutaneous injection, while the mice in the control group were injected with the same amount of normal saline...
February 2018: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/29451226/final-adult-height-and-endocrine-complications-in-young-adults-with-%C3%AE-thalassemia-major-tm-who-received-oral-iron-chelation-oic-in-comparison-with-those-who-did-not-use-oic
#11
Ashraf T Soliman, Mohamed A Yassin, Vincenzo De Sanctis
BACKGROUND: Relatively little is known about endocrine function, bone mineral health, and growth during oral iron chelation therapy in β-thalassemia major patients (TM) on treatment with deferasirox. AIMS OF THE STUDY: To study the frequency of endocrine complications, IGF-1 levels and final adult standing height (FA-Ht) in patients with BTM in two groups of adult patients. PATIENTS AND METHODS: The first group (Group A; 15 patients, 6 females and 9 males) received oral iron chelation therapy (OIC) with deferasirox for 6 years before puberty; the second group (Group B;40 patients) attained the FA-Ht before the use of OIC (iron chelation therapy with deferoxamine (DFO) given subcutaneously, since the age of 2 years)...
February 16, 2018: Acta Bio-medica: Atenei Parmensis
https://www.readbyqxmd.com/read/29422321/broad-variability-in-pharmacokinetics-of-gh-following-rhgh-injections-in-children
#12
Elena Lundberg, Björn Andersson, Berit Kriström, Sten Rosberg, Kerstin Albertsson-Wikland
OBJECTIVE: Daily subcutaneous self-injection of GH is used worldwide to treat short stature in childhood; longitudinal data on the impact of this regimen on GH-uptake are lacking. DESIGN: Children with/without GH-deficiency participating in clinical trials were followed prospectively (≤8 times). Blood was sampled pre-GH-injection (dose GH33 /GH67  μg/kg) and either every 30 min thereafter for 24 h (Experimental-setting; 59 GH-curves/15 children); or every 2 h thereafter for 16 h (Clinical-setting; 429 GH-curves/117 children)...
February 1, 2018: Growth Hormone & IGF Research
https://www.readbyqxmd.com/read/29417370/treatment-of-adult-growth-hormone-deficiency-with-human-recombinant-growth-hormone-an-update-on-current-evidence-and-critical-review-of-advantages-and-pitfalls
#13
REVIEW
Ana M Ramos-Leví, Mónica Marazuela
Adult-onset growth-hormone (GH) deficiency (GHD) is a rare disorder, which most commonly results from pituitary or peripituitary tumors and their treatment, and is characterized by alterations in body composition, carbohydrate and lipid metabolism, bone mineral density, cardiovascular risk profile and quality of life, all of which may contribute to an increased morbidity and mortality. Since recombinant human GH (rhGH) became available in 1985, several studies have provided evidence of its beneficial effects, despite the potential risk of developing adverse effects, and much clinical experience has been accumulated...
May 2018: Endocrine
https://www.readbyqxmd.com/read/29344080/effects-of-huang-bai-phellodendri-cortex-on-bone-growth-and-pubertal-development-in-adolescent-female-rats
#14
Sun Haeng Lee, Hyun Jeong Lee, Sung Hyun Lee, Young-Sik Kim, Donghun Lee, Jiu Chun, Jin Yong Lee, Hocheol Kim, Gyu Tae Chang
Background: To evaluate the effects of Huang Bai (Phellodendron amurense) on growth and maturation in adolescent female rats. Methods: Female Sprague-Dawley rats (28 days old; n = 72) were divided into six daily treatment groups: control (distilled water), Huang Bai (100 and 300 mg/kg), recombinant human GH (rhGH; 20 μg/kg), estradiol (1 μg/kg), and triptorelin (100 μg). Body weight, food intake, and vaginal opening were measured daily from postnatal day (PND) 28 to PND 43...
2018: Chinese Medicine
https://www.readbyqxmd.com/read/29337026/effect-of-recombinant-human-growth-hormone-on-rotator-cuff-healing-after-arthroscopic-repair-preliminary-result-of-a-multicenter-prospective-randomized-open-label-blinded-end-point-clinical-exploratory-trial
#15
Joo Han Oh, Seok Won Chung, Kyung-Soo Oh, Jae Chul Yoo, Wonhee Jee, Jung-Ah Choi, Yang-Soo Kim, Jin-Young Park
BACKGROUND: This study evaluated the effect of systemic injection of recombinant human growth hormone (rhGH) on outcomes after arthroscopic rotator cuff repair. METHODS: This multicenter, prospective, randomized, comparative trial, randomized patients who underwent arthroscopic repair of large-sized rotator cuff tears into 3 groups: rhGH 4 mg group (n = 26), rhGH 8 mg group (n = 24) , and control group (n = 26). Sustained release rhGH was injected subcutaneously once weekly for 3 months postoperatively...
January 11, 2018: Journal of Shoulder and Elbow Surgery
https://www.readbyqxmd.com/read/29318462/long-term-response-to-recombinant-human-growth-hormone-treatment-a-new-predictive-mathematical-method
#16
G Migliaretti, S Ditaranto, C Guiot, S Vannelli, P Matarazzo, N Cappello, I Stura, F Cavallo
INTRODUCTION: Recombinant GH has been offered to GH-deficient (GHD) subjects for more than 30 years, in order to improve height and growth velocity in children and to enhance metabolic effects in adults. AIM: The aim of our work is to describe the long-term effect of rhGH treatment in GHD pediatric patients, suggesting a growth prediction model. MATERIAL AND METHODS: A homogeneous database is defined for diagnosis and treatment modalities, based on GHD patients afferent to Hospital Regina Margherita in Turin (Italy)...
January 9, 2018: Journal of Endocrinological Investigation
https://www.readbyqxmd.com/read/29302920/a-balanced-reciprocal-translocation-t-10-15-q22-3-q26-1-interrupting-acan-gene-in-a-family-with-proportionate-short-stature
#17
M Crippa, S Giangiobbe, R Villa, I Bestetti, T De Filippis, L Fatti, J Taurino, L Larizza, L Persani, F Bellini, P Finelli, M T Bonati
PURPOSE: Few examples of the involvement of a single gene in idiopathic short stature have been described until now. Our aim was to identify the causative gene of proportionate short stature in a large family showing co-segregation of the phenotype with the reciprocal translocation t(10;15)(q22;q24). METHODS: FISH mapping was carried out with BACs and long-range PCR probes to identify the smallest genomic regions harboring the translocation breakpoints. Real-Time RT-PCR was performed in blood after pre-amplification of target genes cDNA...
January 4, 2018: Journal of Endocrinological Investigation
https://www.readbyqxmd.com/read/29274063/effects-of-growth-hormone-on-thyroid-function-are-mediated-by-type-2-iodothyronine-deiodinase-in-humans
#18
Ichiro Yamauchi, Yoriko Sakane, Takafumi Yamashita, Keisho Hirota, Yohei Ueda, Yugo Kanai, Yui Yamashita, Eri Kondo, Toshihito Fujii, Daisuke Taura, Masakatsu Sone, Akihiro Yasoda, Nobuya Inagaki
PURPOSE: Growth hormone (GH) therapy in adults alters thyroid function, and acromegaly often involves thyroid disease. The present study aimed to elucidate roles and mechanisms of GH in regulating thyroid function. METHODS: We performed two retrospective observational studies, which focused on consecutive patients with severe adult GH deficiency who received recombinant human GH (rhGH) therapy (n = 20) and consecutive patients with acromegaly who underwent transsphenoidal surgery (TSS) (n = 25)...
February 2018: Endocrine
https://www.readbyqxmd.com/read/29219047/the-effects-of-genetic-polymorphism-on-treatment-response-of-recombinant-human-growth-hormone
#19
Shi Chen, Hanxiao You, Hui Pan, Huijuan Zhu, Hongbo Yang, Fengying Gong, Linjie Wang, Yu Jiang, Chengsheng Yan
Recombinant human growth hormone (rhGH) has been widely used in clinical treatment of growth hormone deficiency (GHD) or non GHD since 1985 and technology have achieved a great development in different long-acting formulations. Although the mathematical models for predicting the growth hormone response could help clinicians get to an individual personalized growth dose, many patients just can't reach the target height and the growth hormone responses differed.Genetic polymorphisms may play a role in the varies of individual responses in this treatment process...
December 6, 2017: Current Drug Metabolism
https://www.readbyqxmd.com/read/29206809/effect-of-recombinant-human-growth-hormone-therapy-on-blood-lipid-and-carotid-intima-media-thickness-in-children-with-growth-hormone-deficiency
#20
Ming Chen, Dongmei Gan, Yili Luo, Sharvan Rampersad, Lu Xu, Shaoling Yang, Nan Li, Hong Li
BackgroundReports on the association between growth hormone deficiency (GHD) and cardiovascular risk factors in children are limited. We aim to investigate the effect of different doses of recombinant human growth hormone (rhGH) therapy on blood lipid and carotid intima-media thickness (cIMT) in Chinese GHD children.MethodsNinety children, including sixty isolated GHD children and thirty healthy children, were enrolled. GHD children were randomly divided into two groups (A and B) according to the rhGH dose given: group A received 0...
January 17, 2018: Pediatric Research
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