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https://www.readbyqxmd.com/read/27109949/kidney-transplantation-in-hiv-infected-recipients-therapeutic-strategy-and-outcomes-in-monocentric-experience
#1
A Baisi, F Nava, B Baisi, E Rubbiani, G Guaraldi, F Di Benedetto, M Giovannoni, A Solazzo, D Bonucchi, G Cappelli
BACKGROUND: In Human immunodeficiency virus (HIV)-positive patients undergoing kidney transplantation, outcomes and immunosuppression (IS) protocol are not yet established due to infectious and neoplastic risks as well as to pharmacokinetic interactions with antiretroviral therapy (TARV). METHODS: We report a retrospective, 1-center study on 18 HIV+ patients undergoing, between October 2007 and September 2015, kidney transplantation (13 cases) or combined kidney-liver transplant (5 cases)...
March 2016: Transplantation Proceedings
https://www.readbyqxmd.com/read/26659460/a-newly-emergent-turkey-arthritis-reovirus-shows-dominant-enteric-tropism-and-induces-significantly-elevated-innate-antiviral-and-t-helper-1-cytokine-responses
#2
Tamer A Sharafeldin, Sunil K Mor, Nader M Sobhy, Zheng Xing, Kent M Reed, Sagar M Goyal, Robert E Porter
Newly emergent turkey arthritis reoviruses (TARV) were isolated from tendons of lame 15-week-old tom turkeys that occasionally had ruptured leg tendons. Experimentally, these TARVs induced remarkable tenosynovitis in gastrocnemius tendons of turkey poults. The current study aimed to characterize the location and the extent of virus replication as well as the cytokine response induced by TARV during the first two weeks of infection. One-week-old male turkeys were inoculated orally with TARV (O'Neil strain). Copy numbers of viral genes were estimated in intestines, internal organs and tendons at ½, 1, 2, 3, 4, 7, 14 days Post inoculation (dpi)...
2015: PloS One
https://www.readbyqxmd.com/read/26292537/efficacy-of-five-commonly-used-disinfectants-against-turkey-arthritis-reovirus
#3
Sunil K Mor, Aschalew Z Bekele, Tamer A Sharafeldin, Robert E Porter, Sagar M Goyal
Since late 2009, an unusual problem of reovirus-related lameness has been seen in market-age tom turkeys in the upper Midwest area of the United States. In this study, we determined the efficacy of five commonly used disinfectants (Virocid, Keno X5, Synergize, One Stroke, and Tek Trol) against turkey arthritis reoviruses (TARVs). For comparison, turkey enteric reovirus (TERV) and chicken arthritis reovirus (CARV) were also included. At their recommended concentrations, all five disinfectants were found to be effective virucidals, inactivating 99...
March 2015: Avian Diseases
https://www.readbyqxmd.com/read/26287002/pathogenicity-of-newly-emergent-turkey-arthritis-reoviruses-in-chickens
#4
Tamer A Sharafeldin, Sunil K Mor, Harsha Verma, Aschalew Z Bekele, Liliya Ismagilova, Sagar M Goyal, Robert E Porter
Turkey arthritis reoviruses (TARVs) were isolated recently from gastrocnemius and digital flexor tendons of lame turkeys with swollen joints and tenosynovitis. These TARVs were genetically different from chicken arthritis reoviruses (CARVs) and produced gastrocnemius tenosynovitis when inoculated into turkey poults. The purpose of this study was to determine the pathogenicity of TARVs in chickens. One-week-old, specific-pathogen-free chicks were inoculated with either a TARV (TARV-MN2 or TARV-O'Neil) or CARV via oral, intratracheal, or footpad routes...
October 2015: Poultry Science
https://www.readbyqxmd.com/read/26090963/characterization-of-water-coordination-to-ferrous-nitrosyl-complexes-with-fac-n2o-cis-n2o2-and-n2o3-donor-ligands
#5
John McCracken, Patrick J Cappillino, Joshua S McNally, Matthew D Krzyaniak, Michael Howart, Paul C Tarves, John P Caradonna
Electron paramagnetic resonance (EPR) experiments were done on a series of S = (3)/2 ferrous nitrosyl model complexes prepared with chelating ligands that mimic the 2-His-1-carboxylate facial triad iron binding motif of the mononuclear nonheme iron oxidases. These complexes formed a comparative family, {FeNO}(7)(N2Ox)(H2O)3-x with x = 1-3, where the labile coordination sites for the binding of NO and solvent water were fac for x = 1 and cis for x = 2. The continuous-wave EPR spectra of these three complexes were typical of high-spin S = (3)/2 transition-metal ions with resonances near g = 4 and 2...
July 6, 2015: Inorganic Chemistry
https://www.readbyqxmd.com/read/25841748/genomic-characterization-of-a-turkey-reovirus-field-strain-by-next-generation-sequencing
#6
Yi Tang, Huaguang Lu, Aswathy Sebastian, Yin-Ting Yeh, Craig A Praul, Istvan U Albert, Si-Yang Zheng
The genome of a turkey arthritis reovirus (TARV) field strain (Reo/PA/Turkey/22342/13), isolated from a turkey flock in Pennsylvania (PA) in 2013, has been sequenced using Next-Generation Sequencing (NGS) on the Illumina MiSeq platform. The genome of the PA TARV field strain was 23,496bp in length with 10 dsRNA segments encoding 12 viral proteins. The lengths of the genomic segments ranged from 1192bp (S4) to 3959bp (L1). The 5' and 3' conserved terminal sequences of the PA TARV field strain were similar to the two Minnesota (MN) TARVs (MN9 and MN10) published recently and avian orthoreovirus (ARV) reference strains...
June 2015: Infection, Genetics and Evolution
https://www.readbyqxmd.com/read/25828424/experimentally-induced-lameness-in-turkeys-inoculated-with-a-newly-emergent-turkey-reovirus
#7
Tamer A Sharafeldin, Sunil K Mor, Aschalew Z Bekele, Harsha Verma, Sally L Noll, Sagar M Goyal, Robert E Porter
Newly emergent turkey arthritis reoviruses (TARVs) have been isolated from cases of lameness in male turkeys over 10 weeks of age. In a previous study, experimental inoculation of TARV in one-week-old turkey poults produced lymphocytic tenosynovitis at four weeks post inoculation but without causing clinical lameness. This study was undertaken to determine if TARV infection at an early age can lead to clinical lameness in birds as they age. One-week-old male turkeys were inoculated orally with a TARV (strain TARV-O'Neil) and monitored for the development of gait defects until 16 weeks of age...
2015: Veterinary Research
https://www.readbyqxmd.com/read/25743416/survival-of-turkey-arthritis-reovirus-in-poultry-litter-and-drinking-water
#8
Sunil K Mor, Harsha Verma, Tamer A Sharafeldin, Robert E Porter, Andre F Ziegler, Sally L Noll, Sagar M Goyal
Turkey reoviruses (TRVs) can cause arthritis, tenosynovitis, and enteric diseases in turkeys, leading to huge economic losses. The TRVs are tentatively divided into turkey arthritis reoviruses (TARVs) and turkey enteric reoviruses (TERVs) depending on the type of disease they produce. This study was conducted to determine the survival of these viruses in autoclaved and nonautoclaved poultry litter and drinking water at room temperature (approx. 25°C). Three isolates of TARV (TARV-O'Neil, TARV-MN2, and TARV-MN4) and one each of TERV (TERV-MN1) and chicken arthritis reovirus (CARV) were used in this study...
April 2015: Poultry Science
https://www.readbyqxmd.com/read/25655814/phylogenetic-analysis-genomic-diversity-and-classification-of-m-class-gene-segments-of-turkey-reoviruses
#9
Sunil K Mor, Douglas Marthaler, Harsha Verma, Tamer A Sharafeldin, Naresh Jindal, Robert E Porter, Sagar M Goyal
From 2011 to 2014, 13 turkey arthritis reoviruses (TARVs) were isolated from cases of swollen hock joints in 2-18-week-old turkeys. In addition, two isolates from similar cases of turkey arthritis were received from another laboratory. Eight turkey enteric reoviruses (TERVs) isolated from fecal samples of turkeys were also used for comparison. The aims of this study were to characterize turkey reovirus (TRV) based on complete M class genome segments and to determine genetic diversity within TARVs in comparison to TERVs and chicken reoviruses (CRVs)...
March 23, 2015: Veterinary Microbiology
https://www.readbyqxmd.com/read/25518435/one-step-real-time-reverse-transcription-pcr-for-the-detection-of-turkey-reoviruses
#10
Sunil K Mor, Harsha Verma, Aschalew Z Bekele, Tamer A Sharafeldin, Robert E Porter, Sagar M Goyal
During late 2010 and early 2011, an unusual problem of lameness and swollen hock joints in commercial turkeys was reported in the upper Midwest, which continues to this day. The disease caused substantial economic losses to turkey producers. Reovirus was isolated from tendons and joint fluids of lame turkeys submitted to the Minnesota Veterinary Diagnostic Laboratory. This study was undertaken to develop a TaqMan real-time reverse transcription-PCR (rRT-PCR) assay for the early detection of turkey reoviruses (both enteric and lameness strains)...
September 2014: Avian Diseases
https://www.readbyqxmd.com/read/25057811/molecular-characterization-of-l-class-genome-segments-of-a-newly-isolated-turkey-arthritis-reovirus
#11
Sunil K Mor, Tamer A Sharafeldin, Robert E Porter, Sagar M Goyal
Seven strains of turkey arthritis reovirus (TARV) isolated from cases of turkey arthritis were characterized on the basis of their L class genome segment sequences, which were then compared with those of turkey enteric reovirus (TERV) and chicken reovirus (CRV). All three L class gene segments of TARVs and TERVs and their encoded proteins λA, λB, and λC were similar in size to those of CRV reference strain S1133. The conserved motifs such as C2H2 zinc-binding motif and conserved polymerase region were present in λA and λB, respectively...
October 2014: Infection, Genetics and Evolution
https://www.readbyqxmd.com/read/25043587/characterization-of-s-class-gene-segments-of-a-newly-isolated-turkey-arthritis-reovirus
#12
Sunil K Mor, Harsha Verma, Tamer A Sharafeldin, Robert E Porter, Naresh Jindal, Andre Ziegler, Sagar M Goyal
We report on the complete characterization of S class gene segments of 12 newly isolated turkey arthritis reoviruses (TARVs) and compare it with that of a turkey enteric reovirus (TERV). Phylogenetic analysis of S2, S3 and S4 genome segments revealed grouping of all TARVs into two lineages while, on the basis of S1 genome segment, only one lineage was found. All TARVs had 95-100% nucleotide identity based on sigma C protein sequences (S1 segment) but varied from 90-100%, 88.9-100% and 88.7-100% on the basis of S2, S3, and S4 genome segments, respectively...
September 2014: Virology
https://www.readbyqxmd.com/read/25041903/tarv-tree-based-analysis-of-rare-variants-identifying-risk-modifying-variants-in-ctnna2-and-cntnap2-for-alcohol-addiction
#13
Chi Song, Heping Zhang
Since the development of next generation sequencing (NGS) technology, researchers have been extending their efforts on genome-wide association studies (GWAS) from common variants to rare variants to find the missing inheritance. Although various statistical methods have been proposed to analyze rare variants data, they generally face difficulties for complex disease models involving multiple genes. In this paper, we propose a tree-based analysis of rare variants (TARV) that adopts a nonparametric disease model and is capable of exploring gene-gene interactions...
September 2014: Genetic Epidemiology
https://www.readbyqxmd.com/read/24988856/occurrence-of-reovirus-infection-in-muscovy-ducks-cairina-moschata-in-south-western-poland
#14
G Woźniakowski, E Samorek-Salamonowicz, A Gaweł
During the summer 2012 an incidence of high mortality, above 44 percent, in two flocks of Muscovy ducklings in Poland was noted. The clinical signs included considerable weight loss and inability to walk. During the post-mortem evaluations dehydration and enteritis, gouty kidneys as well as hemorrhagic liver and spleen lesions were found. The laboratory diagnosis included agar gel precipitation assay (AGP) as well as polymerase chain reaction (PCR) or reverse transcription PCR for the presence of goose parvovirus (GPV), duck circovirus (DuCV), duck reovirus (DRV) and avian reovirus (ARV)...
2014: Polish Journal of Veterinary Sciences
https://www.readbyqxmd.com/read/24980420/the-role-of-avian-reoviruses-in-turkey-tenosynovitis-arthritis
#15
Tamer A Sharafeldin, Sunil K Mor, Aschalew Z Bekele, Harsha Verma, Sagar M Goyal, Robert E Porter
Turkey arthritis reovirus (TARV) has been isolated from the gastrocnemius tendons and tibiotarsal joint fluid of lame male turkeys >12 weeks old in the Midwest. Two experiments were conducted to compare the pathogenicity in turkeys of three TARVs (TARV-MN2, TARV-MN4 and TARV-O'Neil), one turkey enteric reovirus (TERV strain MN1) and one chicken arthritis reovirus (CARV strain MN1). Two hundred microlitres of virus were inoculated by the oral, intratracheal, or footpad route into 6-day-old poults placed in isolator units...
2014: Avian Pathology: Journal of the W.V.P.A
https://www.readbyqxmd.com/read/24733021/outcomes-in-a-cohort-of-women-who-discontinued-maternal-triple-antiretroviral-regimens-initially-used-to-prevent-mother-to-child-transmission-during-pregnancy-and-breastfeeding-kenya-2003-2009
#16
Timothy D Minniear, Sonali Girde, Frank Angira, Lisa A Mills, Clement Zeh, Philip J Peters, Rose Masaba, Richard Lando, Timothy K Thomas, Allan W Taylor
BACKGROUND: In 2012, the World Health Organization (WHO) amended their 2010 guidelines for women receiving limited duration, triple-antiretroviral drug regimens during pregnancy and breastfeeding for prevention of mother-to-child transmission of HIV (tARV-PMTCT) (Option B) to include the option to continue lifelong combination antiretroviral therapy (cART) (Option B+). We evaluated clinical and CD4 outcomes in women who had received antiretrovirals for prevention of mother-to-child transmission and then discontinued antiretrovirals 6-months postpartum...
2014: PloS One
https://www.readbyqxmd.com/read/24363016/-epidemiological-clinical-and-evolving-hiv-positive-patients-referred-to-the-university-hospital-of-point-g-bamako-mali
#17
A M Traoré, D K Minta, M Fomba, H Cissé, K Diallo, I Coulibaly, A Soukho-Kaya, S A Beye, T Cissé, M Dembélé, H A Traoré, E Bissagnené
We conduct a longitudinal descriptive study in the department of infectious diseases to CHU of Point G during 18 months. It concerned adult patients referred from another care center. All the patients underwent systematic clinical examination and complementary exploration. Our sample was 352 HIV+ patients, with a mean age of 37.8 ± 9.8 years and a sex ratio (M/F)=0.94 shared among patients receiving ARV treatment (ART-s) and not (n-ART). Delay of reference was 5 ± 4.4 days. All patients benefited from clinical and paraclinical examinations...
February 2014: Bulletin de la Société de Pathologie Exotique
https://www.readbyqxmd.com/read/23678736/isolation-and-characterization-of-a-turkey-arthritis-reovirus
#18
Sunil K Mor, Tamer A Sharafeldin, Robert E Porter, Andre Ziegler, Devi P Patnayak, Sagar M Goyal
During the spring and summer of 2011, the Minnesota Veterinary Diagnostic Laboratory at the University of Minnesota received 14 submissions of 15-to-18-week-old tom turkeys that were recumbent with wing tip bruises ("wing walkers") and uni- or bilateral swelling of the hock (tibiotarsal) joints. Gastrocnemius or digital flexor tendons were occasionally ruptured. A total of five turkey arthritis reoviruses (TARV-MN1 through TARV-MN5) were isolated in specific-pathogen-free embryonated chicken eggs and QT-35 cells...
March 2013: Avian Diseases
https://www.readbyqxmd.com/read/22976286/habit-formation-among-regular-exercisers-at-fitness-centers-an-exploratory-study
#19
Karyn Tappe, Ellen Tarves, Jayme Oltarzewski, Deirdra Frum
BACKGROUND: Predictive modeling for physical activity behavior has included many different psychological components, including planning, motivation, personality, and self-efficacy. However, habit formation in exercise maintenance has not been well explored and lacks reliable measurement tools. The current study explores novel survey questions that examine behavioral components of exercise habit, including frequency, environmental cuing, and temporal constancy of behavior. We then relate these concepts to an established psychological measure of habit, the Self-Report Habit Inventory (SRHI)...
May 2013: Journal of Physical Activity & Health
https://www.readbyqxmd.com/read/22480983/changes-of-metabolic-and-inflammatory-markers-in-hiv-infection-glucose-lipids-serum-hs-crp-and-myeloperoxidase
#20
Danielle Cristyane Kalva Borato, Gisele Chibinski Parabocz, Sônia Regina Weber Ribas, Carlos Augusto Kalva-Filho, Luciana Maria Borba, Carmen Antonia Sanches Ito, Larissa Bail, Fábio André dos Santos, José Carlos Rebuglio Vellosa
OBJECTIVE: HIV infection is exacerbated through additional pro-atherogenic mechanisms related to the processes of immune activation, inflammation, coagulation, and the modification of lipoproteins (e.g., particles of high density lipoprotein), contributing to increased cardiovascular risk. The aim of this study was to analyze the serum concentrations of myeloperoxidase (MPO) and other laboratory parameters in HIV-infected patients treated or not with antiretroviral drugs compared to non-infected individuals...
October 2012: Metabolism: Clinical and Experimental
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