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Trasplant infection

Sanjay K Yadav, Sanjiv Saigal, Narendra S Choudhary, Sujit Saha, Navin Kumar, Arvinder S Soin
Cytomegalovirus (CMV) infection is the most common viral infection in liver transplant recipients, affecting post-transplant patients and graft survival. Recent advances in diagnosis and management of CMV have led to marked reduction in incidence, severity, and its associated morbidity and mortality. CMV DNA assay is the most commonly used laboratory parameter to diagnose and monitor CMV infection. Current evidence suggests that both pre-emptive and universal prophylaxis approaches are equally justified in liver transplant recipients...
June 2017: Journal of Clinical and Experimental Hepatology
J Zurita, D W Denning, A Paz-Y-Miño, M B Solís, L M Arias
There is a dearth of data from Ecuador on the burden of life-threatening fungal disease entities; therefore, we estimated the burden of serious fungal infections in Ecuador based on the populations at risk and available epidemiological databases and publications. A full literature search was done to identify all epidemiology papers reporting fungal infection rates. WHO, ONU-AIDS, Index Mundi, Global Asthma Report, Globocan, and national data [Instituto Nacional de Estadística y Censos (INEC), Ministerio de Salud Pública (MSP), Sociedad de Lucha Contra el Cáncer (SOLCA), Instituto Nacional de Donación y Trasplante de Órganos, Tejidos y Células (INDOT)] were reviewed...
June 2017: European Journal of Clinical Microbiology & Infectious Diseases
Yazmín Rocío Arias-Murillo, Karime Osorio-Arango, Jorge Alberto Cortés, Mauricio Beltrán
INTRODUCTION: Cytomegalovirus infections have gained high importance for individuals that have received organ transplants given the clinical implications this may have in immunocompromised patients.  OBJECTIVE: To describe the seroprevalence of cytomegalovirus in organ donors and recipients of kidney transplants nationwide from the six regions established by the Red Nacional de Donación y Trasplante.  MATERIALS AND METHODS: We conducted a descriptive retrospective study that included 1,813 organ donors and 3,313 recipients of kidney transplants, and we calculated IgM and IgG seroprevalence for cytomegalovirus...
May 4, 2016: Biomédica: Revista del Instituto Nacional de Salud
Jussara Aparecida Souza do Nascimento Rodrigues, Renata Eloah de Lucena Ferretti-Rebustini, Vanessa de Brito Poveda
OBJECTIVES: to analyze the occurrence and predisposing factors for surgical site infection in patients submitted to heart transplantation, evaluating the relationship between cases of infections and the variables related to the patient and the surgical procedure. METHOD: retrospective cohort study, with review of the medical records of patients older than 18 years submitted to heart transplantation. The correlation between variables was evaluated by using Fisher's exact test and Mann-Whitney-Wilcoxon test...
August 29, 2016: Revista Latino-americana de Enfermagem
Eva González-Barca, Miguel A Canales, Antonio Salar, Secundino Ferrer, Eva Domingo-Domenech, María-Jesús Vidal, Carlos Grande, Joan Bargay, Santiago Gardella, Albert Oriol, Javier Briones, Javier García-Frade, Jose L Bello, Jose J Sánchez-Blanco, Francisco Javier Peñalver, Jose Francisco Tomás, Antonio Asensio, Andrés López, Dolores Caballero
BACKGROUND/AIMS: Rituximab-cyclophosphamide, doxorubicin, vincristine, and prednisone (R-CHOP) every 14 days seems to achieve better outcomes than R-CHOP every 21 days in diffuse large B-cell lymphoma (DLBCL) patients. Currently, the standard regimen is R-CHOP every 21 days. METHODS: This is a phase II clinical trial of treatment with 6 cycles of R-CHOP-14 with pegfilgrastim support in 2 populations of previously untreated DLBCL patients aged ≥65 years (n = 73) or <65 years (n = 51) with low-risk International Prognostic Index scores (0-2)...
2016: Acta Haematologica
Antonio Salar, Eva Domingo-Domenech, Carlos Panizo, Concepción Nicolás, Joan Bargay, Ana Muntañola, Miguel Canales, José Luis Bello, Juan Manuel Sancho, José Francisco Tomás, María José Rodríguez, Francisco Javier Peñalver, Carlos Grande, José Javier Sánchez-Blanco, Luis Palomera, Reyes Arranz, Eulogio Conde, Mar García, Juan Fernando García, Dolores Caballero, Carlos Montalbán
BACKGROUND: No standard first-line systemic treatment for mucosa-associated lymphoid tissue (MALT) lymphoma is available. In a phase 2 study we aimed to assess the safety and activity of a response-adapted combination of bendamustine plus rituximab as upfront treatment for this type of lymphoma. METHODS: In a multicentre, single-arm, non-randomised, phase 2 trial, we enrolled patients with MALT lymphoma at any site and stage and treated them with bendamustine (90 mg/m(2) on days 1 and 2) plus rituximab (375 mg/m(2) on day 1), every 4 weeks...
December 2014: Lancet Haematology
R Martino, G Bautista, R Parody, I García, A Esquirol, M Rovira, J R Cabrera, C Regidor, R Fores, J A García-Marco, D Serrano, P Barba, I Heras, F J Marquez-Malaver, I Sánchez-Ortega, R Duarte, S Saavedra, J Sierra, L Vazquez
BACKGROUND: Umbilical cord blood transplantation (CBT) is an established alternative source of stem cells in the setting of unrelated transplantation. When compared with other sources, single-unit CBT (sCBT) is associated with a delayed hematologic recovery, which may lead to a higher infection-related mortality (IRM). Co-infusion with the sCBT of CD34+ peripheral blood stem cells from a third-party donor (TPD) (sCBT + TPDCD34+) has been shown to markedly accelerate leukocyte recovery, potentially reducing the IRM...
April 2015: Transplant Infectious Disease: An Official Journal of the Transplantation Society
Alexios Matikas, George Kanellis, Christos Papadimitriou, Theodora Papadaki, Athanasios Kotsakis, Meletios A Dimopoulos, Vassilis Georgoulias
BACKGROUND: Plasmablastic lymphoma (PBL) is a rare entity which is often causally related to infection by the Human Immunodeficiency Virus (HIV). Despite its predilection for oral cavity involvement, multiple cases of extra-oral involvement have been reported in the literature, more often among immunocompetent individuals. CASE REPORT: Herein we present the first case of primary PBL of the breast in an otherwise immunocompetent 36-year-old woman who was successfully treated with consolidation megatherapy and autologous stem cell transplantation...
September 2014: Anticancer Research
R Hladun, I Badell, M González, A M Martínez, J Sánchez de Toledo, M T Olivé, M E González, I Elorza, C Díaz de Heredia
INTRODUCTION: Children with primary immunodeficiency have severe life-threatening infections and a higher prevalence of autoimmune problems, allergy and lymphoproliferative disorders. Allogenic hematopoietic stem cell transplantation has been the only potentially curative option. PATIENTS AND METHODS: Patients with primary immunodeficiency underwent allogenic stem cell transplantation in the period 1985-2011, and registered in the Spanish Working Party for Bone Marrow Transplantation in Children...
February 2015: Anales de Pediatría: Publicación Oficial de la Asociación Española de Pediatría (A.E.P.)
Cristina Costa, Rossana Cavallo
Polyomaviruses BK and JC are ubiquitous viruses with high seroprevalence rates in general population. Following primary infection, polyomaviruses BK and JC persist latently in different sites, particularly in the reno-urinary tract. Reactivation from latency may occur in normal subjects with asymptomatic viruria, while it can be associated to nephropathy (PVAN) in kidney transplantat recipients. PVAN may occur in 1%-10% of renal transplant patients with loss of the transplanted organ in 30% up to 80% of the cases...
December 24, 2012: World Journal of Transplantation
Tetsushi Yoshikawa
Human herpesvirus 6B (HHV-6B) is causative agent for exanthem subitum, which is common febrile illness in infant. This disease is generally benign and self-limited disease, however rarely causes several central nervous system complications. As various types of HHV-6B encephalitis has been demonstrated, pathophysiology of the disease would be complicate. Thus, different therapeutic strategies should be established for each type of HHV-6B encephalitis at the time of primary viral infection. Meanwhile, this virus can reactivate in transplant recipients and cause post-trasplant limbic encephalitis...
2012: Rinshō Shinkeigaku, Clinical Neurology
Josep M Campistol, Valentín Cuervas-Mons, Nicolás Manito, Luis Almenar, Manuel Arias, Fernando Casafont, Domingo Del Castillo, María G Crespo-Leiro, Juan F Delgado, J Ignacio Herrero, Paloma Jara, José M Morales, Mercedes Navarro, Federico Oppenheimer, Martín Prieto, Luis A Pulpón, Antoni Rimola, Antonio Román, Daniel Serón, Piedad Ussetti
Solid-organ transplant recipients are at increased risk of developing cancer compared with the general population. Tumours can arise de novo, as a recurrence of a preexisting malignancy, or from the donated organ. The ATOS (Aula sobre Trasplantes de Órganos Sólidos; the Solid-Organ Transplantation Working Group) group, integrated by Spanish transplant experts, meets annually to discuss current advances in the field. In 2011, the 11th edition covered a range of new topics on cancer and transplantation. In this review we have highlighted the new concepts and best practices for managing cancer in the pre-transplant and post-transplant settings that were presented at the ATOS meeting...
October 2012: Transplantation Reviews
Luis Almenar, Javier Segovia, María G Crespo-Leiro, Jesús Palomo, José M Arizón, Manuel Cobo, Juan Delgado
INTRODUCTION AND OBJECTIVES: The purpose of this report is to present the results obtained with heart transplantation since this therapeutic modality first began to be used in Spain in May 1984. METHODS: A descriptive analysis was performed of all heart transplantation performed until December 31, 2010. RESULTS: The total number of transplants is 6291. The average clinical profile of the Spanish heart transplant patient in 2010 was that of a 53-year-old male diagnosed with nonrevascularizable ischemic heart disease accompanied by severely depressed ventricular function and poor functional status...
December 2011: Revista Española de Cardiología
M Ortega, F Marco, A Soriano, M Almela, J A Martínez, J López, C Pitart, J Mensa
We attempt to describe the epidemiology and outcome associated with cefotaxime-resistant (CTX-R) Klebsiella spp bacteraemia. Klebsiella spp bloodstream infection episodes prospectively collected through a blood culture surveillance programme from January 1991 to December 2008 in a single institution were analysed. A total of 910 monomicrobial episodes of Klebsiella spp bacteraemia were identified during the study period. The most important sources were from urinary tract infection, unknown sources, billiary focus and catheter related infection...
December 2011: European Journal of Clinical Microbiology & Infectious Diseases
D Regidor, F J Ahijado, M A Muñoz, M Romero, A Roca, R Diaz-Tejeiro, I Leal, J L Conde
Fever in an immunocompromised patient like the transplanted subject is usually due to an overt or occult infection. Clinicians must make important decisions to find the cause of fever, and also concerning the timing and adequacy of empiric antibiotic therapy. However, occasionally, fever is not due to an infectious cause. A correct identification of its causes may avoid a needlessly prolonged course of antibiotics. Herein we have reported a kidney transplant patient with a febrile syndrome, which appeared after endovascular aortoiliac stent-graft placement, that was finally attributed to a noninfectious cause like postimplantation syndrome...
December 2009: Transplantation Proceedings
Carmen Martínez, Carlos Solano, Christelle Ferrá, Antonia Sampol, David Valcárcel, José Antonio Pérez-Simón
We conducted a phase II trial to investigate the safety and efficacy of alemtuzumab in treating steroid-refractory acute graft-versus-host disease (aGVHD) grade II or higher after stem cell transplantation. Ten adult patients (6 with aGVHD grade III and 4 with aGVHD grade IV) were included in the study. Nine patients had gastrointestinal tract involvement, 7 had skin involvement, and 5 had liver involvement. Five patients responded to treatment, 2 with complete response and 3 with partial response. Eight infectious events (4 of grade 3-4) and 7 cytomegalovirus (CMV) reactivations were observed...
May 2009: Biology of Blood and Marrow Transplantation
Angel Asensio, Antonio Ramos, Valentin Cuervas-Mons, Elisa Cordero, Victor Sánchez-Turrión, Marino Blanes, Carlos Cervera, Joan Gavalda, Jose M Aguado, Julian Torre-Cisneros
Surgical site infections are common bacterial infections in orthotopic liver transplantation. The purpose of this study was to determine the incidence, timing, location, and risk factors, specifically antibiotic prophylaxis, for surgical site infections. A prospective study was performed that included a population of 1222 consecutive patients (73.0% males) who underwent liver transplantation in Spanish hospitals belonging to the Red de Estudio de la Infección en el Trasplante research network. One hundred seven patients developed surgical site infections...
June 2008: Liver Transplantation
(no author information available yet)
No abstract text is available yet for this article.
February 2008: Gastroenterología y Hepatología
B Bernieh, N Nezamuddin, I A Sirwal, A Wafa, M A Abbade, B Nasser, Z Al Razzaz
We reviewed the records of the renal transplant patients followed at our hospital to determine short-term outcome and complications. Sixty-five renal transplant patients, follow-up for two years were included in this study. Of these patients 40 (61.5%) were males, 33 (50.7%) were Saudis with mean age of 37.2 +/- 11.7 years. Donors were living related (LRD) in 23 (35%), living non-related (LNRD) in 27 (42%) and cadaveric (CAD) in 15 (23%). Thirty-two transplants were carried out at Medinah, 21 in India and the rest in other centers inside Saudi Arabia...
October 1999: Saudi Journal of Kidney Diseases and Transplantation
Amparo Solé, Miguel Salavert
Invasive fungal infections (IFI) are the third cause of infectious complications in recipients of solid organ transplants (SOT), showing an incidence of 5-42% depending of the trasplanted organ. Moreover, IFI account for significant morbility and mortality in SOT, ranging between 25-95% depending on the type of fungus and its organ localization. Different strategies (prophylaxis, preemptive treatment, treatment, antifungal combinations, routes of administration) have been tested to improve the prognosis of IFI in SOT...
September 30, 2007: Revista Iberoamericana de Micología
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