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https://www.readbyqxmd.com/read/28339300/genetic-manipulation-by-zinc-finger-nucleases-in-rat-induced-pluripotent-stem-cells
#1
Sheng Yang, Shufang Ding, Qianhua Xu, Xiong Li, Qiong Xiong
Induced pluripotent stem cells (iPSCs) have an extensive application in regenerative medicine, pharmaceutical discovery, and basic research. With the recent derivation of rat iPSCs, it is now feasible to apply genetic manipulation in this species. But such tools do not yet exist for many rat strains, especially for disease model rat. The Sprague Dawley (SD) rat is an inbred disease model for hypertension, nephropathy, pulmonary hypertension, depression, and alcohol consumption. In this study, the SD rat iPSCs were generated using lentiviral method...
March 24, 2017: Cellular Reprogramming
https://www.readbyqxmd.com/read/28334154/ethical-issues-of-crispr-technology-and-gene-editing-through-the-lens-of-solidarity
#2
John J Mulvihill, Benjamin Capps, Yann Joly, Tamra Lysaght, Hub A E Zwart, Ruth Chadwick
Background: The avalanche of commentaries on CRISPR-Cas9 technology, a bacterial immune system modified to recognize any short DNA sequence, cut it out, and insert a new one, has rekindled hopes for gene therapy and other applications and raised criticisms of engineering genes in future generations. Sources of data: This discussion draws on articles that emphasize ethics, identified partly through PubMed and Google, 2014-2016. Areas of agreement: CRISPR-Cas9 has taken the pace and prospects for genetic discovery and applications to a high level, stoking anticipation for somatic gene engineering to help patients...
February 23, 2017: British Medical Bulletin
https://www.readbyqxmd.com/read/28333339/platelet-rich-plasma-augments-adipose-derived-stem-cell-growth-and-differentiation
#3
Robert P Gersch, Joshua Glahn, Michael G Tecce, Anthony J Wilson, Ivona Percec
Background: Adipose-derived stem cells (ASCs) are a powerful tool for cosmetic surgery and regenerative medicine. The use of autologous platelet rich plasma (PRP), particularly in combination with ASC-based therapy, has significantly expanded in recent years. Unfortunately, the mechanisms and optimal dosing responsible for the beneficial effects of PRP remain poorly understood. Here we investigate the effect of PRP on ASC growth and differentiation. Objectives: To assess the impact of different PRP feeding and cryopreservation protocols on ASC isolation, expansion, and differentiation...
February 22, 2017: Aesthetic Surgery Journal
https://www.readbyqxmd.com/read/28328840/osteopathic-manipulative-treatment-showed-reduction-of-length-of-stay-and-costs-in-preterm-infants-a-systematic-review-and-meta-analysis
#4
Diego Lanaro, Nuria Ruffini, Andrea Manzotti, Gianluca Lista
BACKGROUND: Osteopathic medicine is an emerging and complementary method used in neonatology. METHODS: Outcomes were the mean difference in length of stay (LOS) and costs between osteopathy and alternative treatment group. A comprehensive literature search of (quasi)- randomized controlled trials (RCTs), was conducted from journal inception to May, 2015. Eligible studies must have treated preterm infants directly in the crib or bed and Osteopathic Manipulative Treatment (OMT) must have been performed by osteopaths...
March 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28302309/best-practices-for-chiropractic-care-for-older-adults-a-systematic-review-and-consensus-update
#5
Cheryl Hawk, Michael J Schneider, Mitchell Haas, Paul Katz, Paul Dougherty, Brian Gleberzon, Lisa Z Killinger, John Weeks
OBJECTIVE: The purpose of this study was to update evidence-based recommendations on the best practices for chiropractic care of older adults. METHODS: The project consisted of a systematic literature review and a consensus process. The following were searched from October 2009 through January 2016: MEDLINE, Index to Chiropractic Literature, CINAHL (Cumulative Index to Nursing and Allied Health Literature), AMED (Allied and Complementary Medicine Database), Alt HealthWatch, Cochrane Database of Systematic Reviews, and Cochrane Registry of Controlled Trials...
March 14, 2017: Journal of Manipulative and Physiological Therapeutics
https://www.readbyqxmd.com/read/28300208/practical-whole-tooth-restoration-utilizing-autologous-bioengineered-tooth-germ-transplantation-in-a-postnatal-canine-model
#6
Mitsuaki Ono, Masamitsu Oshima, Miho Ogawa, Wataru Sonoyama, Emilio Satoshi Hara, Yasutaka Oida, Shigehiko Shinkawa, Ryu Nakajima, Atsushi Mine, Satoru Hayano, Satoshi Fukumoto, Shohei Kasugai, Akira Yamaguchi, Takashi Tsuji, Takuo Kuboki
Whole-organ regeneration has great potential for the replacement of dysfunctional organs through the reconstruction of a fully functional bioengineered organ using three-dimensional cell manipulation in vitro. Recently, many basic studies of whole-tooth replacement using three-dimensional cell manipulation have been conducted in a mouse model. Further evidence of the practical application to human medicine is required to demonstrate tooth restoration by reconstructing bioengineered tooth germ using a postnatal large-animal model...
March 16, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28297572/safety-and-efficacy-of-megakaryocytes-induced-from-hematopoietic-stem-cells-in-murine-and-nonhuman-primate-models
#7
Xin Guan, Meng Qin, Yu Zhang, Yanan Wang, Bin Shen, Zhihua Ren, Xinxin Ding, Wei Dai, Yongping Jiang
Because of a lack of platelet supply and a U.S. Food and Drug Administration-approved platelet growth factor, megakaryocytes have emerged as an effective substitute for alleviating thrombocytopenia. Here, we report the development of an efficient two-stage culture system that is free of stroma, animal components, and genetic manipulations for the production of functional megakaryocytes from hematopoietic stem cells. Safety and functional studies were performed in murine and nonhuman primate models. One human cryopreserved cord blood CD34(+) cell could be induced ex vivo to produce up to 1...
March 2017: Stem Cells Translational Medicine
https://www.readbyqxmd.com/read/28289164/challenges-and-opportunities-in-modeling-pancreatic-cancer
#8
Michael E Feigin, David A Tuveson
The ability to faithfully model complex processes lies at the heart of experimental biology. Although a reductionist approach necessarily reduces this complexity, it is nevertheless required for untangling the contributions and interactions of the various system components. It has long been appreciated that cancer is a complex process that involves positive and negative interactions between tumor cells, normal host tissue, and the associated cells of the tumor microenvironment. However, accurate models for studying these complex interactions in vitro have remained elusive...
March 13, 2017: Cold Spring Harbor Symposia on Quantitative Biology
https://www.readbyqxmd.com/read/28280896/surgeon-manipulated-live-surgery-video-recording-apparatuses-personal-experience-and-review-of-literature
#9
REVIEW
Emin Kapi
BACKGROUND: Visual recording of surgical procedures is a method that is used quite frequently in practices of plastic surgery. While presentations containing photographs are quite common in education seminars and congresses, video-containing presentations find more favour. For this reason, the presentation of surgical procedures in the form of real-time video display has increased especially recently. Appropriate technical equipment for video recording is not available in most hospitals, so there is a need to set up external apparatus in the operating room...
March 9, 2017: Aesthetic Plastic Surgery
https://www.readbyqxmd.com/read/28275890/a-survey-of-auditory-display-in-image-guided-interventions
#10
REVIEW
David Black, Christian Hansen, Arya Nabavi, Ron Kikinis, Horst Hahn
PURPOSE: This article investigates the current state of the art of the use of auditory display in image-guided medical interventions. Auditory display is a means of conveying information using sound, and we review the use of this approach to support navigated interventions. We discuss the benefits and drawbacks of published systems and outline directions for future investigation. METHODS: We undertook a review of scientific articles on the topic of auditory rendering in image-guided intervention...
March 8, 2017: International Journal of Computer Assisted Radiology and Surgery
https://www.readbyqxmd.com/read/28264722/efficacy-and-safety-of-manual-acupuncture-manipulations-with-different-frequencies-on-epigastric-pain-syndrome-eps-in-functional-dyspepsia-fd-patients-study-protocol-for-a-randomized-controlled-trial
#11
Shou-Hai Hong, Sha-Sha Ding, Fei Wu, Ying Bi, Fu Xu, Yi-Jia Wan, Li-Hua Xuan
BACKGROUND: Manual acupuncture (MA) manipulations are one of the key factors influencing acupuncture effects in traditional Chinese medicine theory. Different MA manipulations contain different stimulating parameters, thus generating different acupuncture responses or effects. Evidence has demonstrated that acupuncture is effective for functional dyspepsia (FD). However, the effects of different stimulating parameters of MA manipulations on FD remain unclear. METHODS/DESIGN: This study is a randomized controlled trial with a four-arm, parallel-group structure...
March 6, 2017: Trials
https://www.readbyqxmd.com/read/28260195/nature-s-combinatorial-biosynthesis-and-recently-engineered-production-of-nucleoside-antibiotics-in-streptomyces
#12
REVIEW
Shawn Chen, William A Kinney, Steven Van Lanen
Modified nucleosides produced by Streptomyces and related actinomycetes are widely used in agriculture and medicine as antibacterial, antifungal, anticancer and antiviral agents. These specialized small-molecule metabolites are biosynthesized by complex enzymatic machineries encoded within gene clusters in the genome. The past decade has witnessed a burst of reports defining the key metabolic processes involved in the biosynthesis of several distinct families of nucleoside antibiotics. Furthermore, genome sequencing of various Streptomyces species has dramatically increased over recent years...
April 2017: World Journal of Microbiology & Biotechnology
https://www.readbyqxmd.com/read/28259496/integrative-acupuncture-and-spinal-manipulative-therapy-versus-either-alone-for-low-back-pain-a-randomized-controlled-trial-feasibility-study
#13
Anupama Kizhakkeveettil, Kevin A Rose, Gena E Kadar, Eric L Hurwitz
OBJECTIVES: The objective of this study was to assess the feasibility of conducting a large-scale randomized controlled trial (RCT) examining whether an integrative care model combining spinal manipulative therapy (SMT) and acupuncture can lead to better outcomes for low back pain (LBP) than either therapy alone. METHODS: This study was conducted at a complementary and alternative medicine university health center. Participants with acute or chronic LBP were randomized to (1) acupuncture, (2) SMT, or (3) integrative acupuncture and SMT groups...
March 1, 2017: Journal of Manipulative and Physiological Therapeutics
https://www.readbyqxmd.com/read/28252046/depletion-of-gangliosides-enhances-articular-cartilage-repair-in-mice
#14
Masatake Matsuoka, Tomohiro Onodera, Kentaro Homan, Fumio Sasazawa, Jun-Ichi Furukawa, Daisuke Momma, Rikiya Baba, Kazutoshi Hontani, Zenta Joutoku, Shinji Matsubara, Tadashi Yamashita, Norimasa Iwasaki
Elucidation of the healing mechanisms in damaged tissues is a critical step for establishing breakthroughs in tissue engineering. Articular cartilage is clinically one of the most successful tissues to be repaired with regenerative medicine because of its homogeneous extracellular matrix and few cell types. However, we only poorly understand cartilage repair mechanisms, and hence, regenerated cartilage remains inferior to the native tissues. Here, we show that glycosylation is an important process for hypertrophic differentiation during articular cartilage repair...
March 2, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28241329/osteopathic-medical-student-practice-of-osteopathic-manipulative-treatment-during-school-break
#15
Stacey Pierce-Talsma, R Mitchell Hiserote, Gregg Lund
CONTEXT: Osteopathic manipulative treatment (OMT) is integral in osteopathic medical education. The timing of the loss of interest, leading to decreasing clinical use, is unclear. Osteopathic medical students' activities during laboratories or rotations are determined by laboratory or preceptor requirements and do not characterize students' interest in or how they value OMT. Students who practice OMT when they are not required to may demonstrate that they are interested in, perceive a positive value of, and have confidence in using OMT...
March 1, 2017: Journal of the American Osteopathic Association
https://www.readbyqxmd.com/read/28240333/bonding-induced-thermal-transport-enhancement-across-a-hard-soft-material-interface-using-molecular-monolayers
#16
Chao Yuan, Mengyu Huang, Yanhua Cheng, Xiaobing Luo
Manipulating thermal transport across hard/soft material interfaces is important for composites which are critical for a wide range of applications, including electronic packaging, thermal storage, sensors and medicine. To increase the interfacial thermal conductance (Gint), a previous strategy has focused on using a self-assembled monolayer (SAM) to bridge the phonon spectra mismatch between the materials constituting the interface. Here, we introduce a general strategy aiming for interfaces which are incompatible with the previous strategy...
February 27, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/28238141/nanoscript-a-versatile-nanoparticle-based-synthetic-transcription-factor-for-innovative-gene-manipulation
#17
Kholud Dardir, Christopher Rathnam, KiBum Lee
Cellular reprogramming and stem cell-based therapies have shown tremendous potential in the field of regenerative medicine. To that end, developing tools to control stem cell fate is an attractive area of research for replacing damaged and diseased cells and reestablishing functional connections for tissue repair. Transcription factor (TFs) proteins are well known to regulate gene expression and direct stem cell fate. Inspired by natural TFs, NanoScript, a nanoparticle (NP)-based platform, mimics TFs to afford control over gene expression and stem cell fate for regenerative medicine...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/28237673/the-placebo-and-nocebo-phenomena-their-clinical-management-and-impact-on-treatment-outcomes
#18
REVIEW
Victor Chavarria, João Vian, Círia Pereira, João Data-Franco, Brisa S Fernandes, Michael Berk, Seetal Dodd
PURPOSE: This overview focuses on placebo and nocebo effects in clinical trials and routine care. Our goal was to propose strategies to improve outcomes in clinical practice, maximizing placebo effects and reducing nocebo effects, as well as managing these phenomena in clinical trials. METHODS: A narrative literature search of PubMed was conducted (January 1980-September 2016). Systematic reviews, randomized controlled trials, observational studies, and case series that had an emphasis on placebo or nocebo effects in clinical practice were included in the qualitative synthesis...
February 22, 2017: Clinical Therapeutics
https://www.readbyqxmd.com/read/28229589/production-of-cinnamyl-alcohol-glucoside-from-glucose-in-escherichia-coli
#19
Wei Zhou, Huiping Bi, Yibin Zhuang, Qinglin He, Hua Yin, Tao Liu, Yanhe Ma
Rosin, a cinnamyl alcohol glucoside, is one of the important ingredients in Rhodiola rosea, which is a valuable medicinal herb used for centuries. Rosin displayed multiple biological activities. The traditional method for producing rosin and derivatives is direct extraction from R. rosea, which suffers from limited availability of natural resources and complicated purification procedure. This work achieved de novo biosynthesis of rosin in Escherichia coli. First, a biosynthetic pathway of aglycon cinnamyl alcohol from phenylalanine was constructed...
March 1, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/28225201/edible-insects-in-china-utilization-and-prospects
#20
REVIEW
Ying Feng, Xiao-Ming Chen, Min Zhao, Zhao He, Long Sun, Cheng-Ye Wang, Wei-Feng Ding
The use of edible insects has a long history in China, where they have been consumed for more than two thousand years. In general, the level of acceptance is high for the consumption of insects in China. Many studies on edible insects have been conducted in the last twenty years, and the scope of the research includes the culture of entomophagy and the identification, nutritional value, farming and breeding of edible insects, in addition to food production and safety. Currently, 324 species of insects from 11 orders are documented that are either edible or associated with entomophagy in China, which include the common edible species, some less commonly consumed species, and some medicinal insects...
February 22, 2017: Insect Science
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