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Manipulative medicine

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https://www.readbyqxmd.com/read/28815178/stem-cell-manipulation-gene-therapy-and-the-risk-of-cancer-stem-cell-emergence
#1
REVIEW
Flora Clément, Elodie Grockowiak, Florence Zylbersztejn, Gaëlle Fossard, Stéphanie Gobert, Véronique Maguer-Satta
Stem cells (SCs) have been extensively studied in the context of regenerative medicine. Human hematopoietic stem cell (HSC)-based therapies have been applied to treat leukemic patients for decades. Handling of mesenchymal stem cells (MSCs) has also raised hopes and concerns in the field of tissue engineering. Lately, discovery of cell reprogramming by Yamanaka's team has profoundly modified research strategies and approaches in this domain. As we gain further insight into cell fate mechanisms and identification of key actors and parameters, this also raises issues as to the manipulation of SCs...
2017: Stem Cell Investigation
https://www.readbyqxmd.com/read/28808130/meeting-report-on-the-asm-conference-on-mechanisms-of-interbacterial-cooperation-and-competition
#2
Bram Lories, Ilse Parijs, Kevin R Foster, Hans P Steenackers
The ASM Conference on Mechanisms of Interbacterial Cooperation and Competition was held in Washington DC, from 1 to 4 March 2017. The conference provided an international forum for sociomicrobiologists from different disciplines to present and discuss new findings. The meeting covered a wide range of topics, spanning molecular mechanisms, ecology, evolution, computation and manipulation of interbacterial interactions, and encompassed social communities in medicine, the natural environment, and industry. This report summarizes the presentations and emerging themes...
August 14, 2017: Journal of Bacteriology
https://www.readbyqxmd.com/read/28805572/personalized-medicine-and-nonmotor-symptoms-in-parkinson-s-disease
#3
Nataliya Titova, K Ray Chaudhuri
Parkinson's disease (PD) is a multineurotransmitter dysfunction related disorder resulting in a range of motor and nonmotor symptoms. Phenotypic heterogeneity is pronounced in PD and nonmotor symptoms dominant subtypes have been described. These endophenotypes may be underpinned by considerable nondopaminergic dysfunction; however, conventional treatment of PD continues to be mostly reliant on dopamine replacement strategy or manipulation of brain dopaminergic pathways. Consequently, treatment of many nondopaminergic nonmotor and some motor symptoms remains a key unmet need...
2017: International Review of Neurobiology
https://www.readbyqxmd.com/read/28803364/volatile-terpenoids-multiple-functions-biosynthesis-modulation-and-manipulation-by-genetic-engineering
#4
REVIEW
Farhat Abbas, Yanguo Ke, Rangcai Yu, Yuechong Yue, Sikandar Amanullah, Muhammad Muzammil Jahangir, Yanping Fan
Terpenoids play several physiological and ecological functions in plant life through direct and indirect plant defenses and also in human society because of their enormous applications in the pharmaceutical, food and cosmetics industries. Through the aid of genetic engineering its role can by magnified to broad spectrum by improving genetic ability of crop plants, enhancing the aroma quality of fruits and flowers and the production of pharmaceutical terpenoids contents in medicinal plants. Terpenoids are structurally diverse and the most abundant plant secondary metabolites, playing an important role in plant life through direct and indirect plant defenses, by attracting pollinators and through different interactions between the plants and their environment...
August 12, 2017: Planta
https://www.readbyqxmd.com/read/28777535/electrospun-nanofibers-new-concepts-materials-and-applications
#5
Jiajia Xue, Jingwei Xie, Wenying Liu, Younan Xia
Electrospinning is a simple and versatile technique that relies on the electrostatic repulsion between surface charges to continuously draw nanofibers from a viscoelastic fluid. It has been applied to successfully produce nanofibers, with diameters down to tens of nanometers, from a rich variety of materials, including polymers, ceramics, small molecules, and their combinations. In addition to solid nanofibers with a smooth surface, electrospinning has also been adapted to generate nanofibers with a number of secondary structures, including those characterized by a porous, hollow, or core-sheath structure...
August 4, 2017: Accounts of Chemical Research
https://www.readbyqxmd.com/read/28768079/hyperbaric-medicine-today-an-historically-noble-discipline-challenged-by-loss-of-critical-access-and-overutilization-invited-commentary
#6
Richard Clarke
As the title implies, much appears amiss with hyperbaric medicine. Long recognized for its life-saving, CNS-sparing,infection-fighting and tissue-salving attributes, its current application has been rightly called into question by a broad cross-section of health care delivery system stakeholders [1, 2, 3, 4, 5]. This paper will examine what lies behind the stunning loss of availability for a majority of the Federal Drug Administration-approved uses, arguably those for which patients have the most to gain. It will address overutilization in the context of an erosion of practice standards and widespread manipulation of the reimbursement process...
January 2017: Undersea & Hyperbaric Medicine: Journal of the Undersea and Hyperbaric Medical Society, Inc
https://www.readbyqxmd.com/read/28759099/effects-of-clinical-exposure-to-osteopathic-manipulative-medicine-on-confidence-levels-of-medical-students
#7
Lisa N Shapiro, Danielle Defoe, Min-Kyung Jung, To Shan Li, Sheldon C Yao
Context: Training in osteopathic manipulative medicine (OMM) is a unique component of the osteopathic medical school curriculum. Indicators of successful OMM programming include student comfort in explaining and performing OMM as well as confidence in using OMM on future patients. Research on the amount of clinical exposure sufficient to achieve this goal is limited. Objectives: To gauge the impact of clinical OMM exposure on medical students' self-assessed understanding of OMM, their ability to discuss, explain, and perform OMM, and their plan to use OMM in their future practice...
August 1, 2017: Journal of the American Osteopathic Association
https://www.readbyqxmd.com/read/28757583/chalcone-derivatives-promising-starting-points-for-drug-design
#8
REVIEW
Marcelo N Gomes, Eugene N Muratov, Maristela Pereira, Josana C Peixoto, Lucimar P Rosseto, Pedro V L Cravo, Carolina H Andrade, Bruno J Neves
Medicinal chemists continue to be fascinated by chalcone derivatives because of their simple chemistry, ease of hydrogen atom manipulation, straightforward synthesis, and a variety of promising biological activities. However, chalcones have still not garnered deserved attention, especially considering their high potential as chemical sources for designing and developing new effective drugs. In this review, we summarize current methodological developments towards the design and synthesis of new chalcone derivatives and state-of-the-art medicinal chemistry strategies (bioisosterism, molecular hybridization, and pro-drug design)...
July 25, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28754949/cell-permeable-nanobodies-for-targeted-immunolabelling-and-antigen-manipulation-in-living-cells
#9
Henry D Herce, Dominik Schumacher, Anselm F L Schneider, Anne K Ludwig, Florian A Mann, Marion Fillies, Marc-André Kasper, Stefan Reinke, Eberhard Krause, Heinrich Leonhardt, M Cristina Cardoso, Christian P R Hackenberger
Functional antibody delivery in living cells would enable the labelling and manipulation of intracellular antigens, which constitutes a long-thought goal in cell biology and medicine. Here we present a modular strategy to create functional cell-permeable nanobodies capable of targeted labelling and manipulation of intracellular antigens in living cells. The cell-permeable nanobodies are formed by the site-specific attachment of intracellularly stable (or cleavable) cyclic arginine-rich cell-penetrating peptides to camelid-derived single-chain VHH antibody fragments...
August 2017: Nature Chemistry
https://www.readbyqxmd.com/read/28752663/platelet-production-from-induced-pluripotent-stem-cells
#10
N Sugimoto, K Eto
Ex vivo production of human platelets has been pursued as an alternative measure to resolve limitations in the supply and safety of current platelet transfusion products. To this end, induced pluripotent stem cells (iPSCs) are considered an ideal global source, as they are not only pluripotent and self-renewing, but are also available from basically any person, have relatively few ethical issues, and are easy to manipulate. From human iPSCs, megakaryocyte (MK) lines with robust proliferation capacity have been established by the introduction of specified sets of genes...
July 28, 2017: Journal of Thrombosis and Haemostasis: JTH
https://www.readbyqxmd.com/read/28751146/ethnophytotechnology-harnessing-the-power-of-ethnobotany-with-biotechnology
#11
John de la Parra, Cassandra L Quave
Ethnobotany (the scientific study of traditional plant knowledge) has aided the discovery of important medicines. However, as single-molecule drugs or synergistic mixtures, these remedies have faced obstacles in production and analysis. Now, advances in bioreactor technology, metabolic engineering, and analytical instrumentation are improving the production, manipulation, and scientific understanding of such remedies.
July 24, 2017: Trends in Biotechnology
https://www.readbyqxmd.com/read/28750664/harvesting-multipotent-progenitor-cells-from-a-small-sample-of-tonsillar-biopsy-for-clinical-applications
#12
Raju Khatri, Michal Arad, Timothy Ortlip, Benjamin A Portney, W Alex Meltzer, Silviu Diaconu, Lorna E Silipino, Ying Wang, David M Kaetzel, Rodney J Taylor, Michal Zalzman
BACKGROUND: Human adult stem cells hold the potential for the cure of numerous conditions and degenerative diseases. They possess major advantages over pluripotent stem cells as they can be derived from donors at any age, and therefore pose no ethical concerns or risk of teratoma tumor formation in vivo. Furthermore, they have a natural ability to differentiate and secrete factors that promote tissue healing without genetic manipulation. However, at present, clinical applications of adult stem cells are limited by a shortage of a reliable, standardized, and easily accessible tissue source which does not rely on specimens discarded from unrelated surgical procedures...
July 27, 2017: Stem Cell Research & Therapy
https://www.readbyqxmd.com/read/28742215/complementary-and-alternative-medicine-use-among-us-adults-with-headache-or-migraine-results-from-the-2012-national-health-interview-survey
#13
Yan Zhang, Jeff A Dennis, Matthew J Leach, Felicity L Bishop, Holger Cramer, Vincent C H Chung, Craig Moore, Romy Lauche, Ron Cook, David Sibbritt, Jon Adams
BACKGROUND: Given the safety concerns regarding pharmacological agents, and the considerable impact of headache and migraine on the sufferer's quality of life, many people seek other treatment options beyond conventional medication and care to address their symptoms; this includes complementary and alternative medicine (CAM). Some CAM interventions have shown promising results in clinical trials of headache and migraine management. Nonetheless, there has been little research exploring the reasons for using CAM, and the types of CAM used, among this population...
July 25, 2017: Headache
https://www.readbyqxmd.com/read/28739341/atomic-force-microscope-as-a-nano-and-micrometer-scale-biological-manipulator-a-short-review
#14
REVIEW
Atsushi Ikai, Rehana Afrin, Masakazu Saito, Takahiro Watanabe-Nakayama
The amazing capacity of atomic force microscope to let us touch the molecular and cellular level samples with a sharp probe stimulated its application to bio-medical field among others. In addition to topographical imaging of the sample surface, a direct mechanical manipulation has attracted innovative minds to develop new methodologies aiming at direct handling of proteins, DNA/RNA, and cells. Measurement of their mechanical properties brought about a vivid picture of their physical nature. Direct handling of individual molecules and cells prompted development of nano-medical applications...
July 21, 2017: Seminars in Cell & Developmental Biology
https://www.readbyqxmd.com/read/28739049/polyporus-and-bupleuri-radix-effectively-alter-peripheral-circadian-clock-phase-acutely-in-male-mice
#15
Hiroaki Motohashi, Haruna Sukigara, Yu Tahara, Keisuke Saito, Mayu Yamazaki, Takuya Shiraishi, Yosuke Kikuchi, Atsushi Haraguchi, Shigenobu Shibata
In mammals, daily physiological events are precisely regulated by an internal circadian clock system. An important function of this system is to readjust the phase of the clock daily. In Japan, traditional herb medicines, so-called crude drugs (Shoyaku), are widely used for many diseases, and some are reported to affect circadian clock impairment, suggesting that some of them might have an ability to modify clock gene expression rhythms. Therefore, from selected 40 crude drugs, finding candidates that control the circadian clock phases was the first purpose of this study...
July 2017: Nutrition Research
https://www.readbyqxmd.com/read/28728596/implementation-of-longevity-promoting-supplements-and-medications-in-public-health-practice-achievements-challenges-and-future-perspectives
#16
REVIEW
Alexander Vaiserman, Oleh Lushchak
BACKGROUND: Most modern societies undergo rapid population aging. The rise in life expectancy, nevertheless, is not accompanied, to date, by the same increment of healthspan. Efforts to increase healthspan by means of supplements and pharmaceuticals targeting aging-related pathologies are presently in spotlight of a new branch in geriatric medicine, geroscience, postulating that aging could be manipulated in such a way that will in parallel allow delay the onset of all age-associated chronic disorders...
July 20, 2017: Journal of Translational Medicine
https://www.readbyqxmd.com/read/28715245/enhanced-rutin-accumulation-in-tobacco-leaves-by-overexpressing-the-ntfls2-gene
#17
Junli Shi, Wenzheng Li, Yulong Gao, Bingwu Wang, Yong Li, Zhongbang Song
Rutin, one of the metabolites of the flavonoid pathway, shows great potential in industrial applications as a key component in pharmaceutical medicines and biological pesticides. Although the genetic manipulation of transcription factors (TFs) could increase rutin levels in plants, the accompanying accumulation of structurally similar chemicals complicates industrial rutin extraction. In this study, we demonstrated remarkably elevated rutin content (3.5-4.4-fold relative to controls) in transgenic tobacco plants by overexpressing NtFLS2...
September 2017: Bioscience, Biotechnology, and Biochemistry
https://www.readbyqxmd.com/read/28703822/spatiotemporal-presentation-of-exogenous-sdf-1-with-plga-nanoparticles-modulates-sdf-1-cxcr4-signaling-axis-in-the-rodent-cortex
#18
D Dutta, K Hickey, M Salifu, C Fauer, C Willingham, S E Stabenfeldt
Stromal cell-derived factor-1 (SDF-1) and its key receptor CXCR4 have been implicated in directing cellular recruitment for several pathological/disease conditions thus also gained considerable attention for regenerative medicine. One regenerative approach includes sustained release of SDF-1 to stimulate prolonged stem cell recruitment. However, the impact of SDF-1 sustained release on the endogenous SDF-1/CXCR4 signaling axis is largely unknown as auto-regulatory mechanisms typically dictate cytokine/receptor signaling...
July 25, 2017: Biomaterials Science
https://www.readbyqxmd.com/read/28698243/influence-of-de-qi-on-the-immediate-analgesic-effect-of-sp6-acupuncture-in-patients-with-primary-dysmenorrhoea-and-cold-and-dampness-stagnation-a-multicentre-randomised-controlled-trial
#19
Min-Yi Zhao, Peng Zhang, Jing Li, Lin-Peng Wang, Wei Zhou, Yan-Xia Wang, Yan-Fen She, Liang-Xiao Ma, Pei Wang, Ni-Juan Hu, Chi Lin, Shang-Qin Hu, Gui-Wen Wu, Ya-Feng Wang, Jun-Jun Sun, Si-Zhu Jiang, Jiang Zhu
OBJECTIVE: The aim of this multicentre randomised controlled trial was to investigate the contribution of de qi to the immediate analgesic effect of acupuncture in patients with primary dysmenorrhoea and the specific traditional Chinese medicine diagnosis cold and dampness stagnation. METHOD: Eighty-eight patients with primary dysmenorrhoea and cold and dampness stagnation were randomly assigned to de qi (n=43) or no de qi (n=45) groups and underwent 30 min of SP6 acupuncture...
July 11, 2017: Acupuncture in Medicine: Journal of the British Medical Acupuncture Society
https://www.readbyqxmd.com/read/28674807/an-efficient-transfection-method-for-differentiation-and-cell-proliferation-of-mouse-embryonic-stem-cells
#20
Jun-Yang Liou, Bor-Sheng Ko, Tzu-Ching Chang
Embryonic stem (ES) cells are an important source of stem cells in tissue engineering and regenerative medicine because of their high self-renewal capacities and differentiation potentials. However, the detailed molecular mechanisms controlling the differentiation and renewal programs in ES cells remained unclear. One of the difficulties in understanding these mechanisms substantially results from the low efficacies of gene manipulation by delivering exogenous gene expression or knockdown of endogenous gene expression with small interfering RNA (siRNA) in ES cells...
2017: Methods in Molecular Biology
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