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Congenital cytomegalovirus

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https://www.readbyqxmd.com/read/28426680/echocardiographic-findings-in-infants-with-presumed-congenital-zika-syndrome-retrospective-case-series-study
#1
Danielle Di Cavalcanti, Lucas V Alves, Geraldo J Furtado, Cleusa C Santos, Fabiana G Feitosa, Maria C Ribeiro, Paulo Menge, Izabelle M Lira, Joao G Alves
OBJECTIVE: To report the echocardiographic evaluation of 103 infants with presumed congenital Zika syndrome. METHODS: An observational retrospective study was performed at Instituto de Medicina Integral Prof. Fernando Figueira (IMIP), Recife, Brazil. 103 infants with presumed congenital Zika syndrome. All infants had microcephaly and head computed tomography findings compatible with congenital Zika syndrome. Zika IgM antibody was detected in cerebrospinal fluid samples of 23 infants...
2017: PloS One
https://www.readbyqxmd.com/read/28419562/international-opinions-and-national-surveillance-suggest-insufficient-consensus-regarding-the-recognition-and-management-practices-of-infants-with-congenital-cytomegalovirus-infections
#2
J Gunkel, J Nijman, M A Verboon-Maciolek, T F W Wolfs, L S de Vries
AIM: This study evaluated the recognition and management practices with regard to congenital cytomegalovirus (cCMV) infections by a select group of experts and through a national surveillance study. METHOD: A questionnaire was sent to international experts involved in mother and infant care in 2014-2015. Monthly surveillance was conducted among Dutch paediatricians for cases of cCMV infections from 2013 until 2015. RESULTS: The questionnaire was completed by 63/103 (62%) respondents, who indicated that recognition and management practices varied...
April 17, 2017: Acta Paediatrica
https://www.readbyqxmd.com/read/28418539/ophthalmic-manifestations-of-congenital-zika-syndrome-in-colombia-and-venezuela
#3
Juan B Yepez, Felipe A Murati, Michele Pettito, Carlos F Peñaranda, Jazmin de Yepez, Gladys Maestre, J Fernando Arevalo
Importance: The ocular manifestations and sequelae of Zika virus infection are not well known. Recently, the World Health Organization changed the declaration of Zika as a public health emergency and designated the viral outbreak and related microcephaly clusters as a long-term program of work. This change indicates the urgent need to evaluate and document ophthalmic manifestations in patients for timely management of this disease. In addition, confirmation whether the public health problem in Brazil extends to other regions in South America is needed...
April 13, 2017: JAMA Ophthalmology
https://www.readbyqxmd.com/read/28416012/congenital-cytomegalovirus-infection-advances-and-challenges-in-diagnosis-prevention-and-treatment
#4
REVIEW
Concetta Marsico, David W Kimberlin
Cytomegalovirus (CMV) is the most frequent cause of congenital infection worldwide, with an estimated incidence in developing countries of 0.6-0.7% of all live births. The burden of disease related to congenital CMV in substantial, as it is the leading non-genetic cause of sensorineural hearing loss and an important cause of neurodevelopmental disabilities in children. Despite its clinical significance, congenital CMV infection often goes undetected because the majority of infected infants are asymptomatic at birth and screening programs have not been substantially implemented...
April 17, 2017: Italian Journal of Pediatrics
https://www.readbyqxmd.com/read/28412596/is-lenticulostriated-vasculopathy-an-unfavorable-prognostic-finding-in-infants-with-congenital-cytomegalovirus-infection
#5
Antonietta Giannattasio, Pasquale Di Costanzo, Paola Milite, Daniela De Martino, Eleonora Capone, Antonia Romano, Carmela Bravaccio, Letizia Capasso, Francesco Raimondi
BACKGROUND: Lenticulostriated vasculopathy (LSV) detected in head ultrasound (HUS) has been related to neurological and hearing sequelae in infants with congenital cytomegalovirus (cCMV) infection. OBJECTIVE: To assess the role of LSV in predicting neurodevelopmental and hearing outcomes in infants with cCMV infection. STUDY DESIGN: We enrolled consecutive infants who were affected by cCMV infection and underwent HUS within the first month of life...
April 6, 2017: Journal of Clinical Virology: the Official Publication of the Pan American Society for Clinical Virology
https://www.readbyqxmd.com/read/28406982/novel-decay-dynamics-revealed-for-virus-mediated-drug-activation-in-cytomegalovirus-infection
#6
Jessica Rose, Vincent C Emery, Deepali Kumar, Anders Asberg, Anders Hartmann, Alan G Jardine, Angelo A Bignamini, Atul Humar, Avidan U Neumann
Human cytomegalovirus (CMV) infection is a substantial cause of morbidity and mortality in immunocompromised hosts and globally is one of the most important congenital infections. The nucleoside analogue ganciclovir (GCV), which requires initial phosphorylation by the viral UL97 kinase, is the mainstay for treatment. To date, CMV decay kinetics during GCV therapy have not been extensively investigated and its clinical implications not fully appreciated. We measured CMV DNA levels in the blood of 92 solid organ transplant recipients with CMV disease over the initial 21 days of ganciclovir therapy and identified four distinct decay patterns, including a new pattern exhibiting a transient viral rebound (Hump) following initial decline...
April 2017: PLoS Pathogens
https://www.readbyqxmd.com/read/28402975/frequent-pul27-variations-in-hiv-infected-patients
#7
Azam Mirarab, Alireza Mohebbi, Abdolvahab Moradi, Naeme Javid, Mohammad Ali Vakili, Alijan Tabarraei
OBJECTIVE: Drug-resistant isolates of human cytomegalovirus (HCMV) have led to the development of new anti-HCMV drugs. Maribavir (MBV) is a novel inhibitor of the HCMV viral kinase. Resistance to MBV is mapped to gene UL27, a viral nuclear protein. In this study, we investigated UL27 polymorphisms in MBV-naive HIV-positive and HCMV congenitally infected clinical samples. METHODS: DNA was extracted from 20 CMV-positive HIV (9/20) and congenitally infected (11/20) patients and used for UL27 polymerase chain reaction amplification...
April 13, 2017: Intervirology
https://www.readbyqxmd.com/read/28399055/long-term-visual-and-ocular-sequelae-in-patients-with-congenital-cytomegalovirus-infection
#8
Haoxing Jin, Gail J Demmler-Harrison, David K Coats, Evelyn A Paysse, Amit Bhatt, Jane C Edmond, Kimberly G Yen, Paul Steinkuller, Jerry Miller
BACKGROUND: Cytomegalovirus (CMV) is the most common congenital viral infection in the United States. Visual and ocular sequelae in adolescents and adults who are congenitally infected with CMV have not been well studied. Better understanding of the long-term visual and ocular sequelae can help with early detection, intervention, and appropriate educational accommodations. METHODS: This study evaluated 237 (77 symptomatic, 109 asymptomatic, and 51 control) patients who underwent a series of age-appropriate ophthalmologic, audiologic, and neurodevelopmental examinations from 1982 to 2013...
April 10, 2017: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/28398680/cytomegalovirus-infection-in-pregnancy
#9
REVIEW
Nicole L Davis, Caroline C King, Athena P Kourtis
Cytomegalovirus (CMV) is a DNA herpesvirus that is common worldwide. The two known main sources of primary CMV infection during pregnancy are through sexual activity and contact with young children. Primary infection occurs in approximately 1 to 4% of pregnancies, and is mostly asymptomatic in immunocompetent adults. However, primary infection may manifest as a mild mononucleosis or flu-like syndrome with persistent fever and fatigue. CMV can be transmitted from mother-to-child in utero, intrapartum, or during breastfeeding...
March 15, 2017: Birth Defects Res
https://www.readbyqxmd.com/read/28395563/persistent-intestinal-bleeding-due-to-severe-cmv-related-thrombocytopenia-in-a-preterm-newborn
#10
Alberto Berardi, Eugenio Spaggiari, Chiara Cattelani, Maria Federica Roversi, Monica Pecorari, Tiziana Lazzarotto, Fabrizio Ferrari
The optimal threshold for neonatal platelet transfusions in sick newborns is still uncertain. We report a congenital cytomegalovirus (CMV) infection in a premature neonate with severe thrombocytopenia who subsequently presented with necrotizing enterocolitis and intestinal bleeding. The baby recovered after platelet transfusions were discontinued and the therapy was switched from intravenous ganciclovir to oral valganciclovir. We discuss both measures, speculating on the key role of platelet transfusions.
April 11, 2017: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/28395562/pcr-tests-for-uterine-cervical-secretion-are-promising-noninvasive-methods-for-predicting-congenital-cytomegalovirus-infection
#11
Kenji Tanimura, Yasuhiko Ebina, Hideto Yamada
No abstract text is available yet for this article.
April 13, 2017: Expert Review of Molecular Diagnostics
https://www.readbyqxmd.com/read/28391502/genomic-analysis-of-chimeric-human-cytomegalovirus-vaccine-candidates-derived-from-strains-towne-and-toledo
#12
Nicolás M Suárez, Betty Lau, George M Kemble, Ronzo Lee, Edward S Mocarski, Gavin W G Wilkinson, Stuart P Adler, Michael A McVoy, Andrew J Davison
Human cytomegalovirus (HCMV) is an important opportunistic pathogen in immunocompromised patients and a major cause of congenital birth defects when acquired in utero. In the 1990s, four chimeric viruses were constructed by replacing genome segments of the high passage Towne strain with segments of the low passage Toledo strain, with the goal of obtaining live attenuated vaccine candidates that remained safe but were more immunogenic than the overly attenuated Towne vaccine. The chimeras were found to be safe when administered to HCMV-seronegative human volunteers, but to differ significantly in their ability to induce seroconversion...
April 8, 2017: Virus Genes
https://www.readbyqxmd.com/read/28383538/long-term-outcomes-of-children-with-symptomatic-congenital-cytomegalovirus-disease
#13
T M Lanzieri, J Leung, A C Caviness, W Chung, M Flores, P Blum, S R Bialek, J A Miller, S S Vinson, M R Turcich, R G Voigt, G Demmler-Harrison
OBJECTIVE: To assess long-term outcomes of children with symptomatic congenital cytomegalovirus (CMV) disease detected at birth. STUDY DESIGN: We used Cox regression to assess risk factors for intellectual disability (intelligence quotient <70), sensorineural hearing loss (SNHL; hearing level ⩾25 dB in any audiometric frequency) and vision impairment (best corrected visual acuity >20 or based on ophthalmologist report). RESULTS: Among 76 case-patients followed through median age of 13 (range: 0-27) years, 56 (74%) had SNHL, 31 (43%, n=72) had intellectual disability and 18 (27%, n=66) had vision impairment; 28 (43%, n=65) had intellectual disability and SNHL with/without vision impairment...
April 6, 2017: Journal of Perinatology: Official Journal of the California Perinatal Association
https://www.readbyqxmd.com/read/28374309/early-and-peri-operative-prognostic-indicators-in-infants-undergoing-hepatic-portoenterostomy-for-biliary-atresia-a-review
#14
REVIEW
Robert N Lopez, Chee Y Ooi, Usha Krishnan
PURPOSE OF REVIEW: Biliary atresia is the most common indication for liver transplantation among children. In recent years, prospective, multi-centre collaboration has been underway with the aim of providing high-quality data on the natural history of the condition, prior to and following hepatic portoenterostomy. RECENT FINDINGS: There is increasing evidence that specific histological findings, and age, at the time of portoenterostomy have relevance as prognostic indicators...
April 2017: Current Gastroenterology Reports
https://www.readbyqxmd.com/read/28369278/cytomegalovirus-urinary-shedding-in-hiv-infected-pregnant-women-and-congenital-cytomegalovirus-infection
#15
Kristina Adachi, Jiahong Xu, Bonnie Ank, D Heather Watts, Lynne M Mofenson, Jose Henrique Pilotto, Esau Joao, Breno Santos, Rosana Fonseca, Regis Kreitchmann, Jorge Pinto, Marisa M Mussi-Pinhata, Glenda Gray, Gerhard Theron, Mariza G Morgado, Yvonne J Bryson, Valdilea G Veloso, Jeffrey D Klausner, Jack Moye, Karin Nielsen-Saines
Background: Cytomegalovirus (CMV) urinary shedding in HIV-infected pregnant women was evaluated to determine whether it poses an increased risk for congenital CMV infection (cCMV). Methods: A subset of mother-infant pairs enrolled in the perinatal NICHD HPTN 040 study (distinguished by no antiretroviral use before labor) was evaluated. Maternal and infant urines were tested by qualitative real-time polymerase chain reaction (RT-PCR) for CMV DNA with quantitative RT-PCR performed on positive specimens...
March 22, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/28368496/characterization-of-human-cytomegalovirus-genome-diversity-in-immunocompromised-hosts-by-whole-genomic-sequencing-directly-from-clinical-specimens
#16
E Hage, G S Wilkie, S Linnenweber-Held, A Dhingra, N M Suárez, J J Schmidt, P Kay-Fedorov, E Mischak-Weissinger, A Heim, A Schwarz, T F Schulz, A J Davison, T Ganzenmueller
Background: Advances in next-generation sequencing (NGS) technologies allow comprehensive studies of genetic diversity over the entire genome of human cytomegalovirus (HCMV), a significant pathogen for immunocompromised individuals. Methods: NGS was performed on target-enriched sequence libraries prepared directly from a variety of clinical specimens (blood, urine, breast-milk, respiratory samples, biopsies and vitreous humor) obtained longitudinally or from different anatomical compartments from 20 HCMV-infected patients (renal transplant recipients, stem cell transplant recipients and congenitally infected children)...
March 27, 2017: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/28356534/mutual-interplay-between-the-human-cytomegalovirus-terminase-subunits-pul51-pul56-and-pul89-promotes-terminase-complex-formation
#17
Sebastian Neuber, Karen Wagner, Thomas Goldne, Peter Lischka, Lars Steinbrueck, Martin Messerle, Eva Maria Borst
Human cytomegalovirus (HCMV) genome encapsidation requires several essential viral proteins, among them pUL56, pUL89 and the recently described pUL51, which constitute the viral terminase. To gain insight into terminase complex assembly, we investigated interactions between the individual subunits. For analysis in the viral context, HCMV bacterial artificial chromosomes carrying deletions in the open reading frames encoding the terminase proteins were used. These experiments were complemented by transient transfection assays with plasmids expressing the terminase components...
March 29, 2017: Journal of Virology
https://www.readbyqxmd.com/read/28338486/congenital-cytomegalovirus-infection-management-update
#18
Asma Khalil, Chrissie Jones, Yves Ville
PURPOSE OF REVIEW: Until recently, management options in congenital cytomegalovirus (cCMV) infection have been either conservative or termination of pregnancy. However, medical therapies aimed at reducing the risk of infection and/or its severity have recently been investigated. RECENT FINDINGS: In a phase 2 open label, nonrandomized trial, valaciclovir (ValACV) was given to women carrying a CMV-infected fetus. ValACV was associated with a greater proportion of asymptomatic neonates when compared with a historical cohort (82 vs...
March 23, 2017: Current Opinion in Infectious Diseases
https://www.readbyqxmd.com/read/28332898/herpes-simplex-virus-1-and-cytomegalovirus-dnas-detection-in-the-inner-ear-of-implanted-patients-with-non-congenital-infection
#19
Walter Di Nardo, Roberta Anzivino, Paola Cattani, Rosaria Santangelo, Eugenio De Corso, Gaetano Paludetti
CONCLUSIONS: The detection of cytomegalovirus (CMV) and herpes simplex virus-1 (HSV-1) genome in perilymph of patients with negative serology or clinical history for congenital infections supports the hypothesis that Herpesviridae, even after acquired postnatal infections, could remain in latent phase in the spiral ganglion and damage the cochlea by a possible subsequent reactivation. Further studies are needed to identify the markers of such reactivation. OBJECTIVE: To identify the presence of certain viral species in the endolabyrinthic fluid of deaf patients with non-congenital infection...
March 23, 2017: Acta Oto-laryngologica
https://www.readbyqxmd.com/read/28322432/bilateral-congenital-deafness-what-investigations-should-be-performed
#20
Nicolas Gürtler, Claudine Gysin, Nevenka Schmid, Claudia Pieren, Mattheus Vischer, Stefan Schumacher, Peter Oppermann, Daniel Leuba, Dorothée Veraguth
BACKGROUND: The introduction of newborn hearing screening has led to earlier identification of children with congenital sensorineural hearing loss (SNHL). Aetiological clarification offers several benefits. There is currently a lack of agreement on which examinations should be recommended. OBJECTIVE: Descriptive review of the literature reporting investigations performed to establish the aetiology of congenital SNHL and comparison of the management policy in Swiss referral centres...
March 21, 2017: Swiss Medical Weekly
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