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Congenital cytomegalovirus

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https://www.readbyqxmd.com/read/29149633/neonatal-and-long-term-ophthalmological-findings-in-infants-with-symptomatic-and-asymptomatic-congenital-cytomegalovirus-infection
#1
Maria Grazia Capretti, Concetta Marsico, Simonetta Guidelli Guidi, Antonio Ciardella, Giuliana Simonazzi, Silvia Galletti, Liliana Gabrielli, Tiziana Lazzarotto, Giacomo Faldella
BACKGROUND: Congenital cytomegalovirus (cCMV) infection is responsible of a high burden of neurosensory impairment in children. OBJECTIVES: To report incidence and consequences of ophthalmological abnormalities in infants with cCMV infection and better define their long-term ophthalmological management. STUDY DESIGN: Infants with cCMV infection were enrolled in a 6-year follow-up. Infants were classified as symptomatic or asymptomatic based on complete clinical, laboratory and instrumental evaluations...
November 7, 2017: Journal of Clinical Virology: the Official Publication of the Pan American Society for Clinical Virology
https://www.readbyqxmd.com/read/29143062/-intracranial-cystic-lesions
#2
REVIEW
F Ahlhelm, K Shariat, S Götschi, S Ulmer
CLINICAL PROBLEM: Intracerebral cysts are common findings in imaging of the neurocranium and are not always clinically significant. The pathological spectrum of intracerebral cysts is, however, very broad and in addition to incidental findings includes developmental disorders, malformation tumors, primary and secondary neoplasms and infectious etiologies, such as cerebral abscess formation, cysticercosis or residuals after congenital cytomegalovirus infections. Intracerebral cystic defects may be caused by inflammatory central nervous system (CNS) diseases, such as multiple sclerosis as well as by mitochondriopathies, leukodystrophy, electrolyte disturbances or osmotic demyelination syndrome or brain infarctions, e...
November 15, 2017: Der Radiologe
https://www.readbyqxmd.com/read/29140947/congenital-cytomegalovirus-a-european-expert-consensus-statement-on-diagnosis-and-management
#3
Suzanne E Luck, Jantien W Wieringa, Daniel Blázquez-Gamero, Philipp Henneke, Katharina Schuster, Karina Butler, Maria Grazia Capretti, Maria José Cilleruelo, Nigel Curtis, Francesca Garofoli, Paul Heath, Elias Iosifidis, Nigel Klein, Giuseppina Lombardi, Hermione Lyall, Tea Nieminen, Dasja Pajkrt, Vassiliki Papaevangelou, Klara Posfay-Barbe, Laura Puhakka, Emmanuel Roilides, Pablo Rojo, Jesús Saavedra-Lozano, Teshri Shah, Mike Sharland, Harri Saxen, Ann C T M Vossen
No abstract text is available yet for this article.
December 2017: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/29139205/congenital-cytomegalovirus-infection-update-on-treatment-scientific-impact-paper-no-56
#4
(no author information available yet)
No abstract text is available yet for this article.
November 15, 2017: BJOG: An International Journal of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/29116590/detection-of-congenital-cytomegalovirus-in-newborns-using-nucleic-acid-amplification-techniques-and-its-public-health-implications
#5
REVIEW
Guoyu Liu, Rong Hai, Fenyong Liu
Human cytomegalovirus (HCMV), a herpesvirus, is an important human pathogen that causes asymptomatic infections in healthy or immunocompetent individuals but can lead to severe and potentially life-threatening complications in immune-immature individuals such as neonates or immune-compromised patients such as organ-transplant recipients and HIV-positive individuals. Congenital HCMV infection represents a significant public health issue and poses substantial healthcare and economic burden to society. This virus causes the most common viral congenital infection worldwide, and is the leading non-genetic cause of sensorineural hearing loss in children in developed countries...
October 2017: Virologica Sinica
https://www.readbyqxmd.com/read/29112951/phenotype-and-specificity-of-t-cells-in-primary-human-cytomegalovirus-infection-during-pregnancy-il-7rpos-long-term-memory-phenotype-is-associated-with-protection-from-vertical-transmission
#6
Federico Mele, Chiara Fornara, David Jarrossay, Milena Furione, Alessia Arossa, Arsenio Spinillo, Antonio Lanzavecchia, Giuseppe Gerna, Federica Sallusto, Daniele Lilleri
Congenital human cytomegalovirus (HCMV) infection is the major cause of birth defects and a precise definition of the HCMV-specific T-cell response in primary infection may help define reliable correlates of immune protection during pregnancy. In this study, a high throughput method was used to define the frequency of CD4+ and CD8+ T cells specific for four HCMV proteins in the naïve compartment of seronegative subjects and the effector/memory compartments of subjects with primary/remote HCMV infection. The naïve repertoire displayed comparable frequencies of T cells that were reactive with HCMV structural (pp65, gB and the pentamer gHgLpUL128L) and non-structural (IE-1) proteins...
2017: PloS One
https://www.readbyqxmd.com/read/29099873/assessing-zika-virus-replication-and-the-development-of-zika-specific-antibodies-after-a-mid-gestation-viral-challenge-in-guinea-pigs
#7
Craig J Bierle, Claudia Fernández-Alarcón, Nelmary Hernandez-Alvarado, Jason C Zabeli, Bradley C Janus, Dira S Putri, Mark R Schleiss
Primary Zika virus (ZIKV) infections that occur during pregnancy can cause spontaneous abortion and profoundly disrupt fetal development. While the full range of developmental abnormalities associated with congenital Zika syndrome is not yet known, severe cases of the syndrome can present with microcephaly, extensive neurologic and ocular damage, and pronounced joint malformations. Animal models that accurately recapitulate congenital Zika syndrome are urgently needed for vaccine development and for the study of ZIKV pathogenesis...
2017: PloS One
https://www.readbyqxmd.com/read/29072089/hyperimmune-globulin-in-pregnancy-for-the-prevention-of-congenital-cytomegalovirus-disease
#8
Giovanni Nigro
Cytomegalovirus (CMV) is the most common and serious cause of congenital infections in developed countries since it is capable of infecting the fetus after both primary and recurrent maternal infection, and can be spread for years by infected children. Areas covered: Animal and human pregnancy studies about the prevention of congenital CMV infection and disease by CMV-specific hyperimmune globulin (HIG). Commercial HIG is manufactured from the plasma of selected donors with high anti-CMV antibody avidity and titers...
November 6, 2017: Expert Review of Anti-infective Therapy
https://www.readbyqxmd.com/read/29066580/intelligence-and-academic-achievement-with-asymptomatic-congenital-cytomegalovirus-infection
#9
Adriana S Lopez, Tatiana M Lanzieri, Angelika H Claussen, Sherry S Vinson, Marie R Turcich, Isabella R Iovino, Robert G Voigt, A Chantal Caviness, Jerry A Miller, W Daniel Williamson, Craig M Hales, Stephanie R Bialek, Gail Demmler-Harrison
OBJECTIVES: To examine intelligence, language, and academic achievement through 18 years of age among children with congenital cytomegalovirus infection identified through hospital-based newborn screening who were asymptomatic at birth compared with uninfected infants. METHODS: We used growth curve modeling to analyze trends in IQ (full-scale, verbal, and nonverbal intelligence), receptive and expressive vocabulary, and academic achievement in math and reading. Separate models were fit for each outcome, modeling the change in overall scores with increasing age for patients with normal hearing (n = 78) or with sensorineural hearing loss (SNHL) diagnosed by 2 years of age (n = 11) and controls (n = 40)...
November 2017: Pediatrics
https://www.readbyqxmd.com/read/29050102/-research-progress-on-the-etiology-of-delayed-onset-hearing-loss-in-children
#10
X Y Wang, L H Huang, Y T Du
Newborn hearing screening is an effective method for early detection of hearing loss, however, it is not able to detect delayed-onset hearing loss. By exploring the etiology of delayed-onset hearing loss in children, it can provide a clinical basis for early detection of delayed-onset hearing loss. Mutations in SLC26A4, mitochondrial, GJB2 and other genes, enlarged vestibular aqueduct, congenital cytomegalovirus infection, extracorporeal membrane oxygenation, and auditory neuropathy et al were more commonly reported risk factors...
October 7, 2017: Zhonghua Er Bi Yan Hou Tou Jing Wai Ke za Zhi, Chinese Journal of Otorhinolaryngology Head and Neck Surgery
https://www.readbyqxmd.com/read/29047343/prevalence-of-congenital-cytomegalovirus-infection-in-symptomatic-newborns-under-3%C3%A2-weeks-in-tehran-iran
#11
Mina Ebrahimi-Rad, Talayeh Seyed Shakeri, Fariba Shirvani, Kiana Shahrokhi, Nader Shahrokhi
BACKGROUND: Cytomegalovirus (CMV) is a common cause of congenital infection worldwide and infants with symptomatic congenital CMV (cCMV) infection are at significantly increased risk of developing adverse long-term outcomes. This study aimed to determine the prevalence of cCMV infections in symptomatic infants under 3 weeks in Tehran, IRAN and to evaluate the usefulness of serologic markers in these neonates. METHODS: Urine and serum samples of 100 symptomatic infants, under 3 weeks old, with clinical signs referred to Tehran medical centers from June 2013 to December 2014, were collected and tested for CMV-DNA and IgG/IgM antibody titers by PCR and ELISA, respectively...
October 18, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/29046458/a-tyrosine-based-trafficking-motif-of-the-tegument-protein-pul71-is-crucial-for-human-cytomegalovirus-secondary-envelopment
#12
Andrea N Dietz, Clarissa Villinger, Stefan Becker, Manfred Frick, Jens von Einem
The human cytomegalovirus (HCMV) tegument protein pUL71 is required for efficient secondary envelopment and accumulates at the Golgi-derived viral assembly complex (vAC) during infection. Analysis of various C-terminally truncated pUL71 fused to eGFP identified amino acids 23-34 as important determinants for its Golgi localization. Sequence analysis and mutational verification revealed the presence of an N-terminal tyrosine-based trafficking motif (YxxΦ) in pUL71. This led us to hypothesize a requirement of the YxxΦ motif for the function of pUL71 in infection...
October 18, 2017: Journal of Virology
https://www.readbyqxmd.com/read/29046308/progress-toward-development-of-a-vaccine-against-congenital-cytomegalovirus-infection
#13
Mark R Schleiss, Sallie R Permar, Stanley A Plotkin
A vaccine against congenital human cytomegalovirus (CMV) infection is a major public health priority. Congenital CMV causes substantial long-term morbidity in newborns, particularly sensorineural hearing loss (SNHL), and the public health impact of this infection on maternal and child health is under-recognized. Although progress toward development of a vaccine has been limited by an incomplete understanding of the correlates of protective immunity for the fetus, knowledge about some of the key components of the maternal immune response necessary for preventing trans-placental transmission is accumulating...
October 18, 2017: Clinical and Vaccine Immunology: CVI
https://www.readbyqxmd.com/read/29032597/more-than-two-years-follow-up-of-infants-with-congenital-cytomegalovirus-infection-in-japan
#14
Shin Koyano, Ichiro Morioka, Akira Oka, Hiroyuki Moriuchi, Kimisato Asano, Yushi Ito, Tetsushi Yoshikawa, Hideto Yamada, Tatsuo Suzutani, Naoki Inoue
BACKGROUND: The aim of the study was to evaluate outcomes of congenital cytomegalovirus (CMV) cases identified by our urine-filter screening assay after follow-up for more than 2 years, and to observe the clinical outcomes after anti-CMV therapies. METHODS: Sixty of the 72 congenital CMV cases were enrolled. Forty-three cases asymptomatic at birth, 7 cases symptomatic at birth but untreated with anti-CMV drugs, and 10 symptomatic cases treated with anti-CMV drugs were clinically observed for more than 2 years...
October 15, 2017: Pediatrics International: Official Journal of the Japan Pediatric Society
https://www.readbyqxmd.com/read/29029807/binding-and-neutralizing-anti-cytomegalovirus-activities-in-immune-globulin-products
#15
Xiao Wang, Yanqun Xu, Dorothy E Scott, Haruhiko Murata, Evi B Struble
Congenital infection as well as infection of immunocompromised individuals by cytomegalovirus (CMV) can be associated with significant morbidity, mortality, and long-term adverse health outcomes. Assessment of anti-viral activity using appropriate assays is essential for ensuring safe and efficacious use of therapeutic CMV immune globulin (IG) products. In this study, we used commercial ELISA kits to compare anti-CMV antibody binding activity and avidity for lots of CMV-specific and normal IG products available in the US market...
October 10, 2017: Biologicals: Journal of the International Association of Biological Standardization
https://www.readbyqxmd.com/read/29023676/neurocognitive-problems-in-children-with-congenital-cytomegalovirus-infection
#16
Hermione Lyall
No abstract text is available yet for this article.
October 12, 2017: Developmental Medicine and Child Neurology
https://www.readbyqxmd.com/read/29022925/anti-cytomegalovirus-immunoglobulin-m-titer-for-congenital-infection-in-first-trimester-pregnancy-with-primary-infection-a-multicenter-prospective-cohort-study
#17
K Toriyabe, F Morikawa, T Minematsu, M Ikejiri, S Suga, T Ikeda
OBJECTIVE: We evaluated cytomegalovirus (CMV) immunoglobulin M (IgM) titer in pregnant women with primary infection as a predictive factor for congenital infection. STUDY DESIGN: Maternal CMV antibody screening during the first trimester was conducted prospectively at 16 centers in Japan between September 2013 and 2015. Women with confirmed maternal primary infection underwent testing for fetal congenital infection, and we investigated the positive predictive value of CMV IgM titer levels for congenital infection in women with a low IgG avidity...
October 12, 2017: Journal of Perinatology: Official Journal of the California Perinatal Association
https://www.readbyqxmd.com/read/29020188/human-cytomegalovirus-specific-memory-cd4-t-cell-response-and-its-correlation-with-virus-transmission-to-the-fetus-in-pregnant-women-with-primary-infection
#18
Chiara Fornara, Irene Cassaniti, Maurizio Zavattoni, Milena Furione, Kodjo M G Adzasehoun, Annalisa De Silvestri, Giuditta Comolli, Fausto Baldanti
Background: Primary human cytomegalovirus (HCMV) infection during pregnancy is the major cause of congenital viral sequelae. The HCMV-specific T-cell response may have a role in the prevention of virus transmission to the fetus. Methods: HCMV-specific memory T cells were investigated in the second month after primary infection onset in 44 pregnant women (15 transmitting the infection to the fetus) and 8 pregnant women with remote infection. Peripheral blood mononuclear cells were stimulated for 12 days with peptide pools of HCMV proteins IE-1, IE-2, and pp65, and subsequently restimulated for 24 hours with the same peptide pools in a cultured enzyme-linked immunospot (ELISPOT) assay...
July 20, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/29020153/universal-screening-with-use-of-immunoglobulin-g-avidity-for-congenital-cytomegalovirus-infection
#19
Kenji Tanimura, Shinya Tairaku, Ichiro Morioka, Kana Ozaki, Satoshi Nagamata, Mayumi Morizane, Masashi Deguchi, Yasuhiko Ebina, Toshio Minematsu, Hideto Yamada
Background: The aim of this prospective cohort study was to evaluate the efficacy of maternal screening for congenital cytomegalovirus infection (CCI) using cytomegalovirus (CMV) immunoglobulin G (IgG) and the IgG avidity index (AI). Methods: Pregnant women underwent screening of CMV IgG and AI measurements. IgG-negative women underwent remeasurement of IgG after educational intervention. Women with an AI ≤45% received further examinations, including measurement of CMV IgM...
October 30, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/29020147/congenital-cytomegalovirus-infection-improved-understanding-of-maternal-immune-responses-that-reduce-the-risk-of-transplacental-transmission
#20
Mark R Schleiss
No abstract text is available yet for this article.
July 20, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
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