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Congenital cytomegalovirus

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https://www.readbyqxmd.com/read/28211317/primary-human-cytomegalovirus-hcmv-infection-in-pregnancy
#1
Horst Buxmann, Klaus Hamprecht, Matthias Meyer-Wittkopf, Klaus Friese
BACKGROUND: In 0.5-4% of pregnancies, the prospective mother sustains a primary infection with human cytomegalovirus (HCMV). An HCMV infection of the fetus in the first or second trimester can cause complex post-encephalitic impairment of the infant brain, leading to motor and mental retardation, cerebral palsy, epilepsy, retinal defects, and progressive hearing loss. METHODS: This review is based on pertinent publications from January 2000 to October 2016 that were retrieved by a selective search in PubMed employing the terms "cytomegalovirus and pregnancy" and "congenital cytomegalovirus...
January 27, 2017: Deutsches Ärzteblatt International
https://www.readbyqxmd.com/read/28209771/hearing-loss-in-children-with-asymptomatic-congenital-cytomegalovirus-infection
#2
Tatiana M Lanzieri, Winnie Chung, Marily Flores, Peggy Blum, A Chantal Caviness, Stephanie R Bialek, Scott D Grosse, Jerry A Miller, Gail Demmler-Harrison
OBJECTIVES: To assess the prevalence, characteristics, and risk of sensorineural hearing loss (SNHL) in children with congenital cytomegalovirus infection identified through hospital-based newborn screening who were asymptomatic at birth compared with uninfected children. METHODS: We included 92 case-patients and 51 controls assessed by using auditory brainstem response and behavioral audiometry. We used Kaplan-Meier survival analysis to estimate the prevalence of SNHL, defined as ≥25 dB hearing level at any frequency and Cox proportional hazards regression analyses to compare SNHL risk between groups...
February 16, 2017: Pediatrics
https://www.readbyqxmd.com/read/28207161/prenatal-diagnosis-of-congenital-cytomegalovirus-infection-in-115-cases-a-5%C3%A2-years-single-centre-experience
#3
M Enders, A Daiminger, S Exler, K Ertan, G Enders, R Bald
OBJECTIVE: To investigate the diagnostic value of invasive prenatal diagnosis (PD) of congenital CMV infection from amniotic fluid (AF) and fetal blood (FB) METHODS: Retrospective study on 115 pregnancies with CMV primary infection. A total of 111 AF and 106 FB samples were investigated for various virological and non-virological markers. Detailed ultrasound examinations were performed at time of PD. RESULTS: Overall sensitivity of CMV PCR in FB (75.6%; 95%CI 60-87) and AF (72...
February 16, 2017: Prenatal Diagnosis
https://www.readbyqxmd.com/read/28202760/restriction-of-hcmv-replication-by-isg15-a-host-effector-regulated-by-cgas-sting-dsdna-sensing
#4
Christopher Bianco, Ian Mohr
Accumulation of the interferon-stimulated gene (ISG) 15 protein product, which is reversibly conjugated to numerous polypeptide targets, impacts the proteome and physiology of uninfected and infected cells. While many viruses, including human cytomegalovirus (HCMV) blunt host antiviral defenses by limiting ISG expression, the overall abundance of ISG15 monomer and protein conjugates rises in HCMV-infected cells. However, the molecular signals underlying ISG15 accumulation and whether the ISG15 polypeptide itself influences HCMV infection biology remain unknown...
February 15, 2017: Journal of Virology
https://www.readbyqxmd.com/read/28195113/congenital-cytomegalovirus-infection-in-a-neonate-born-to-hiv-infected-mother-a-case-report
#5
Dhaneshwar Namdeorao Lanjewar, Sushma Nagsen Ramraje
No abstract text is available yet for this article.
January 2017: Indian Journal of Pathology & Microbiology
https://www.readbyqxmd.com/read/28166842/seroprevalence-of-cytomegalovirus-infection-in-france-in-2010
#6
D Antona, A Lepoutre, L Fonteneau, C Baudon, F Halftermeyer-Zhou, Y LE Strat, D Lévy-Bruhl
Cytomegalovirus (CMV) infection remains the leading cause of congenital virus infection in developed countries. Measuring the national prevalence of this infection, especially among women of childbearing age, is of great value to estimate the risk of congenital CMV infection, as well as to identify risk groups that should be targeted for behavioural interventions and/or vaccination once a CMV vaccine finally becomes available. In order to fulfil these objectives, a seroprevalence survey was conducted in 2010, using a nationally representative, population-based sample of 2536 people aged between 15 and 49 years, living in metropolitan France and attending private microbiological laboratories for blood testing...
February 7, 2017: Epidemiology and Infection
https://www.readbyqxmd.com/read/28158709/cytomegalovirus-dna-detection-by-polymerase-chain-reaction-in-cerebrospinal-fluid-of-infants-with-congenital-infection-associations-with-clinical-evaluation-at-birth-and-implications-for-follow-up
#7
Walter-Alfredo Goycochea-Valdivia, Fernando Baquero-Artigao, Teresa Del Rosal, Marie-Antoinette Frick, Pablo Rojo, María-Juncal Echeverría, Antoni Noguera-Julian, Xavier Bringué, Jesús Saavedra-Lozano, Isabel Vives-Oñós, Elisenda Moliner, María-José Cilleruelo, Irene Cuadrado, Elena Colino, Laura Castells, Alfredo Tagarro, Javier Vilas, Pere Soler-Palacin, Daniel Blázquez-Gamero
No abstract text is available yet for this article.
February 4, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/28151899/cohort-study-on-maternal-cytomegalovirus-seroprevalence-and-prevalence-and-clinical-manifestations-of-congenital-infection-in-china
#8
Shiwen Wang, Tongzhan Wang, Wenqiang Zhang, Xiaolin Liu, Xiaofang Wang, Haiyan Wang, Xiaozhou He, Shunxian Zhang, Shuhui Xu, Yang Yu, Xingbing Jia, Maolin Wang, Aiqiang Xu, Wei Ma, Minal M Amin, Stephanie R Bialek, Sheila C Dollard, Chengbin Wang
Congenital cytomegalovirus (CMV) infection is the leading viral cause of birth defects and developmental disabilities in developed countries. However, CMV seroprevalence and burden of congenital CMV infection are not well defined in China.Cohort of newborns from 5 birthing hospitals in 2 counties of Shandong Province, China, were enrolled from March 2011 to August 2013. Dried blood spots (DBS) and saliva were collected within 4 days after birth for IgG testing for maternal seroprevalence and real-time PCR testing for congenital CMV infection, respectively...
February 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28151075/association-of-snps-from-il1a-il1b-and-il6-genes-with-human-cytomegalovirus-infection-among-pregnant-women
#9
Wioletta Izabela Wujcicka, Jan Szczęsny Wilczyński, Dorota Ewa Nowakowska
The study was aimed to estimate the role and prevalence rates of genotypes, haplotypes, and alleles, located within the single-nucleotide polymorphisms (SNPs) of interleukin (IL) 1A, IL1B, and IL6 genes, in the occurrence and development of human cytomegalovirus (HCMV) infection among pregnant women. A research was conducted in 129 pregnant women, out of whom, 65 were HCMV infected and 64 were age-matched control uninfected individuals. HCMV DNA was quantitated for UL55 gene by the real-time Q PCR in the body fluids...
February 2, 2017: Viral Immunology
https://www.readbyqxmd.com/read/28122986/tnf%C3%AE-induced-recruitment-of-inflammatory-mononuclear-cells-leads-to-inflammation-and-altered-brain-development-in-mcmv-infected-newborn-mice
#10
Maria C Seleme, Kate Kosmac, Stipan Jonjic, William J Britt
: Congenital human cytomegalovirus (HCMV) infection is a significant cause of abnormal neurodevelopment and long term neurological sequelae in infants and children. Resident cell populations of the developing brain have been suggested to be more susceptible to virus-induced cytopathology, a pathway thought to contribute to the clinical outcomes following intrauterine HCMV infection. However, recent findings in a newborn mouse model of this infection in the developing brain have indicated that elevated levels of proinflammatory mediators leading to mononuclear cell activation and recruitment could underlie the abnormal neurodevelopment...
January 25, 2017: Journal of Virology
https://www.readbyqxmd.com/read/28119427/screening-for-congenital-cytomegalovirus-after-newborn-hearing-screening-what-comes-next
#11
Scott D Grosse, Sheila C Dollard, David W Kimberlin
No abstract text is available yet for this article.
January 24, 2017: Pediatrics
https://www.readbyqxmd.com/read/28119425/outcomes-from-a-hearing-targeted-cytomegalovirus-screening-program
#12
Marissa L Diener, Cathleen D Zick, Stephanie Browning McVicar, Jill Boettger, Albert H Park
BACKGROUND AND OBJECTIVES: Cytomegalovirus (CMV) is the most common congenital infection and nongenetic cause of congenital sensorineural hearing loss in the United States. Utah was the first state to pass legislation mandating CMV screening for newborns who fail newborn hearing screening (NBHS). The study objective was to present outcomes of hearing-targeted CMV screening and determine factors predicting CMV screening. METHODS: We used Utah Department of Health HiTrack and Vital Records databases to examine CMV screening from 509 infants who failed NBHS in the 24 months after implementation of the Utah legislation...
January 24, 2017: Pediatrics
https://www.readbyqxmd.com/read/28118851/tlr2-2258-g-a-single-nucleotide-polymorphism-and-the-risk-of-congenital-infection-with-human-cytomegalovirus
#13
Wioletta Wujcicka, Edyta Paradowska, Mirosława Studzińska, Jan Wilczyński, Dorota Nowakowska
BACKGROUND: Human cytomegalovirus (HCMV) is responsible for the most common intrauterine infections, which may be acquired congenitally from infected pregnant woman to fetus. The research was aimed to estimate the role of three single nucleotide polymorphisms (SNPs) located in TLR2 gene, and the common contribution of TLR2, and previously studied TLR4 and TLR9 SNPs, to the occurrence of congenital HCMV infection in fetuses and newborns. METHODS: The study was performed in 20 Polish fetuses and newborns, congenitally infected with HCMV, and in 31 uninfected controls, as well as with participation of pregnant women, the mothers of 16 infected and 14 uninfected offsprings...
January 24, 2017: Virology Journal
https://www.readbyqxmd.com/read/28116961/primary-versus-non-primary-maternal-cytomegalovirus-infection-as-a-cause-of-symptomatic-congenital-infection-register-based-study-from-finland
#14
Laura Puhakka, Marjo Renko, Merja Helminen, Ville Peltola, Tarja Heiskanen-Kosma, Maija Lappalainen, Heljä-Marja Surcel, Tuula Lönnqvist, Harri Saxen
BACKGROUND: Both primary and non-primary maternal cytomegalovirus (CMV) infection during pregnancy can lead to vertical transmission. We evaluated the proportion of maternal primary/non-primary infections among 26 babies with symptomatic congenital CMV infection born in Finland from 2000 to 2012. METHODS: We executed a database search on hospital records from all five university hospitals in Finland to identify infants with congenital CMV infection. The preserved maternal serum samples drawn at the end of the first trimester were analysed for CMV antibodies...
January 24, 2017: Infectious Diseases
https://www.readbyqxmd.com/read/28110288/screening-for-seemingly-healthy-newborns-with-congenital-cytomegalovirus-infection-by-quantitative-real-time-polymerase-chain-reaction-using-newborn-urine-an-observational-study
#15
Akira Yamaguchi, Tsutomu Oh-Ishi, Takashi Arai, Hideaki Sakata, Nodoka Adachi, Satoshi Asanuma, Eiji Oguma, Hirofumi Kimoto, Jiro Matsumoto, Hidetoshi Fujita, Tadashi Uesato, Jutaro Fujita, Ken Shirato, Hideki Ohno, Takako Kizaki
OBJECTIVE: Approximately 8-10% of newborns with asymptomatic congenital cytomegalovirus (cCMV) infection develop sensorineural hearing loss (SNHL). However, the relationship between CMV load, SNHL and central nervous system (CNS) damage in cCMV infection remains unclear. This study aimed to examine the relationship between urinary CMV load, SNHL and CNS damage in newborns with cCMV infection. STUDY DESIGN: The study included 23 368 newborns from two maternity hospitals in Saitama Prefecture, Japan...
January 20, 2017: BMJ Open
https://www.readbyqxmd.com/read/28081328/cytomegalovirus-hepatitis-in-49-pediatric-patients-with-normal-immunity
#16
Hasan Tezer, Saliha Kanık Yüksek, Belgin Gülhan, Aslı Nur Özkaya Parlakay, Ceyda Tuna Kırsaçlıoğlu
BACKGROUND/AIM: Cytomegalovirus (CMV) hepatitis is generally asymptomatic or rarely can lead to severe complications in immunocompetent hosts. This study aims to evaluate CMV hepatitis in immunocompetent young children, which is discussed relatively rarely in the literature. MATERIALS AND METHODS: A retrospective review of 49 pediatric patients with CMV hepatitis from January 2005 to December 2010 was performed. RESULTS: The median age of the patients was 5...
December 20, 2016: Turkish Journal of Medical Sciences
https://www.readbyqxmd.com/read/28079836/symptomatic-cytomegalovirus-infections-in-the-first-year-of-life-when-is-antiviral-therapy-conceived-to-be-justified
#17
Katharina Schuster, Rangmar Goelz, Carsten Speckmann, Philipp Henneke
All infants treated with antiviral medication for symptomatic congenital (diagnosis <3 weeks) and probably postnatal (>3 weeks) cytomegalovirus infection were characterized with the help of a survey covering all German Pediatric hospitals between 2012 and 2013. We found that >50% of infants treated for cytomegalovirus were classified as probably postnatal cytomegalovirus infection, which was associated with preterm birth and underlying diseases of the immune system, heart or lung.
February 2017: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/28079113/congenital-hearing-loss
#18
REVIEW
Anna M H Korver, Richard J H Smith, Guy Van Camp, Mark R Schleiss, Maria A K Bitner-Glindzicz, Lawrence R Lustig, Shin-Ichi Usami, An N Boudewyns
Congenital hearing loss (hearing loss that is present at birth) is one of the most prevalent chronic conditions in children. In the majority of developed countries, neonatal hearing screening programmes enable early detection; early intervention will prevent delays in speech and language development and has long-lasting beneficial effects on social and emotional development and quality of life. A diagnosis of hearing loss is usually followed by a search for an underlying aetiology. Congenital hearing loss might be attributed to environmental and prenatal factors, which prevail in low-income settings; congenital infections, particularly cytomegalovirus infection, are also a common risk factor for hearing loss...
12, 2017: Nature Reviews. Disease Primers
https://www.readbyqxmd.com/read/28077654/neutralization-of-diverse-human-cytomegalovirus-strains-conferred-by-antibodies-targets-viral-gh-gl-pul128-131-pentameric-complex
#19
Sha Ha, Fengsheng Li, Matthew C Troutman, Daniel C Freed, Aimin Tang, John W Loughney, Dai Wang, I-Ming Wang, Josef Vlasak, David C Nickle, Richard R Rustandi, Melissa Hamm, Pete A DePhillips, Ningyan Zhang, Jason S McLellan, Hua Zhu, Stuart P Adler, Michael A McVoy, Zhiqiang An, Tong-Ming Fu
: Human cytomegalovirus (HCMV) is the leading cause of congenital viral infection and developing a prophylactic vaccine is of high priority to public health. We recently reported a replication-defective human cytomegalovirus with restored pentameric complex gH/gL/pUL128-131 for prevention of congenital HCMV infection. While the quantity of vaccine-induced antibody responses can be measured in a viral neutralization assay, assessing the quality of such responses, including the ability of vaccine-induced antibodies to cross neutralize the field strains of HCMV, remains a challenge...
January 11, 2017: Journal of Virology
https://www.readbyqxmd.com/read/28077639/identification-of-a-continuous-neutralizing-epitope-within-ul128-of-human-cytomegalovirus
#20
Flavia Chiuppesi, Teodora Kaltcheva, Meng Zhuo, Peter A Barry, Don J Diamond, Felix Wussow
: As human cytomegalovirus (HCMV) is the most common infectious cause of fetal anomalies during pregnancy, developing a vaccine that prevents HCMV infection is considered a global health priority. Although HCMV immune correlates of protection are only poorly defined, neutralizing antibodies (NAb) targeting the envelope pentamer complex (PC) composed of subunits gH, gL, UL128, UL130, and UL131A are thought to contribute in preventing HCMV infection. Here, we describe a continuous target sequence within UL128 that is recognized by a previously isolated potent PC-specific NAb, termed 13B5...
January 11, 2017: Journal of Virology
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