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Congenital cytomegalovirus

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https://www.readbyqxmd.com/read/29784513/racial-and-ethnic-differences-in-the-prevalence-of-congenital-cytomegalovirus-infection
#1
Karen B Fowler, Shannon A Ross, Masako Shimamura, Amina Ahmed, April L Palmer, Marian G Michaels, David I Bernstein, Pablo J Sánchez, Kristina N Feja, Audra Stewart, Suresh Boppana
OBJECTIVE: To evaluate the impact of race and ethnicity upon the prevalence and clinical spectrum of congenital cytomegalovirus infection (cCMV). STUDY DESIGN: From 2007 to 2012, 100 332 infants from 7 medical centers were screened for cCMV while in the hospital. Ethnicity and race were collected and cCMV prevalence rates were calculated. RESULTS: The overall prevalence of cCMV in the cohort was 4.5 per 1000 live births (95% CI, 4.1-4.9)...
May 18, 2018: Journal of Pediatrics
https://www.readbyqxmd.com/read/29769344/efficient-delivery-of-hcmv-t-cell-antigens-by-attenuated-sendai-virus-vectors
#2
Richard Kiener, Markus Fleischmann, Marian Alexander Wiegand, Niels A W Lemmermann, Christiane Schwegler, Christine Kaufmann, Angelique Renzaho, Simone Thomas, Eva Felder, Hans Helmut Niller, Benedikt Asbach, Ralf Wagner
Human Cytomegalovirus (HCMV) represents a major cause of clinical complications during pregnancy as well as immunosuppression and the licensing of a protective HCMV vaccine remains an unmet global need. Herein, we designed and validated novel Sendai virus (SeV) vectors delivering T cell immunogens IE-1 and pp65. To enhance vector safety, we used a replication-deficient strain (rdSeV) that infects target cells in a non-productive manner while retaining viral gene expression. In this study, we explored the impact that transduction with rdSeV has on human dendritic cells (DCs) by comparing it to the parental, replication-competent Sendai virus strain (rcSeV) as well as the poxvirus strain Modified Vaccinia Ankara (MVA)...
May 16, 2018: Journal of Virology
https://www.readbyqxmd.com/read/29768731/cochlear-implant-performance-in-children-deafened-by-congenital-cytomegalovirus-a-systematic-review
#3
V J C Kraaijenga, F Van Houwelingen, S F Van der Horst, J Visscher, J M L Huisman, E J Hollman, I Stegeman, A L Smit
BACKGROUND: Congenital cytomegalovirus (cCMV) infection is a major cause of sensorineural hearing loss in children. OBJECTIVE OF REVIEW: The objective of this systematic review was to compare performance in pediatric cochlear implant users with SNHL caused by cCMV compared to non-cCMV implantees. TYPE OF REVIEW: Systematic review. SEARCH STRATEGY: Pubmed, EMBASE and the Cochrane databases were searched from inception up to May 15th 2017 for children, cochlear implant, performance and their synonyms...
May 16, 2018: Clinical Otolaryngology
https://www.readbyqxmd.com/read/29761033/diagnosis-and-treatment-of-congenital-sensorineural-hearing-loss
#4
Divya A Chari, Dylan K Chan
Purpose of Review: The aim of this report is to review current literature regarding the work-up and management of congenital sensorineural hearing loss. Recent Findings: Diagnostic evaluation of a newborn with sensorineural hearing loss begins with a complete audiologic evaluation and comprehensive history and physical exam. This review presents a diagnostic algorithm for the work-up of congenital hearing loss, focusing on the three following modalities: cytomegalovirus testing, genetic evaluation, and imaging...
December 2017: Current Otorhinolaryngology Reports
https://www.readbyqxmd.com/read/29753934/recovery-of-cytomegalovirus-dna-from-newborn-saliva-samples-by-different-methods
#5
Oran Goshen, David M Goldfarb, Laura Book, Peter Tilley, Soren Gantt
BACKGROUND: Polymerase chain reaction (PCR) testing of saliva swabs has been shown to be an attractive method to screen for congenital cytomegalovirus (CMV) infection. However, few data are available regarding the impact of pre-analytic methods on CMV DNA recovery from saliva samples under various conditions. OBJECTIVES: The purpose of this study was to evaluate the impact of various transport media and transport conditions on the recovery of CMV DNA from spiked and clinical saliva samples from newborns using PCR testing...
May 5, 2018: Journal of Clinical Virology: the Official Publication of the Pan American Society for Clinical Virology
https://www.readbyqxmd.com/read/29747890/detection-and-prevention-of-perinatal-infection-cytomegalovirus-and-zika-virus
#6
REVIEW
Amber M Wood, Brenna L Hughes
Congenital cytomegalovirus is the most common viral congenital infection, and affects up to 2% of neonates. Significant sequelae may develop after congenital cytomegalovirus, including hearing loss, cognitive defects, seizures, and death. Zika virus is an emerging virus with perinatal implications; a congenital Zika virus syndrome has been identified, and includes findings such as microcephaly, fetal nervous system abnormalities, and neurologic sequelae after birth. Screening, diagnosis, prevention, and treatment of these perinatal infections are reviewed in this article...
June 2018: Clinics in Perinatology
https://www.readbyqxmd.com/read/29746374/direct-saliva-real-time-polymerase-chain-reaction-assay-shows-low-birth-prevalence-of-congenital-cmv-infection-in-urban-western-india
#7
Rajlakshmi Viswanathan, Sanjay Bafna, Ravikanth Mergu, Gururajrao Deshpande, Rashmi Gunjikar, Shivshankar Gaikwad, Jayati Mullick
BACKGROUND: Congenital cytomegalovirus infection is the leading infectious cause of mental retardation, developmental delay and sensorineural deafness. Non primary infection plays a major role in transmission of this infection in countries with high maternal seroprevalence. Non invasive sampling and testing is a useful alternative to traditional methods of laboratory detection of congenital CMV infection. The present study was conducted to understand birth prevalence of congenital cytomegalovirus (cCMV) infection using molecular techniques, in an urban setting of a developing country with evidence of high maternal seroprevalence...
May 9, 2018: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/29735300/clinical-factor-associated-with-congenital-cytomegalovirus-infection-in-pregnant-women-with-non-primary-infection
#8
Hideto Yamada, Kenji Tanimura, Shinya Tairaku, Ichiro Morioka, Masashi Deguchi, Mayumi Morizane, Satoshi Nagamata, Kana Ozaki, Yasuhiko Ebina, Toshio Minematsu
The aim of this nested case-control study was to evaluate clinical factors associated with the occurrence of congenital cytomegalovirus (CMV) infection in pregnant women with non-primary CMV infection. In a cohort study of CMV screening for 2193 pregnant women and their newborns, seven newborns with congenital CMV infection were identified among 1287 pregnant women with non-primary CMV infection that was defined as negative IgM and positive IgG with IgG avidity index >45%. In the 1287 women with non-primary CMV infection, clinical findings and complications were compared between pregnancies with and without congenital CMV infection...
May 5, 2018: Journal of Infection and Chemotherapy: Official Journal of the Japan Society of Chemotherapy
https://www.readbyqxmd.com/read/29720077/australian-paediatric-surveillance-unit-annual-report-2016
#9
Marie Deverell, Amy Phu, Yvonne Zurynski, Elizabeth Elliott
This report summarises the cases reported to the Australian Paediatric Surveillance Unit (APSU) of rare infectious diseases or rare complications of more common infectious diseases in children. During the calendar year 2016, there were approximately 1500 paediatricians reporting to the APSU and the monthly report card return rate was 90%. APSU continued to provide unique national data on the perinatal exposure to HIV, congenital rubella, congenital cytomegalovirus, neonatal and infant herpes simplex virus, and congenital and neonatal varicella...
September 1, 2017: Communicable Diseases Intelligence Quarterly Report
https://www.readbyqxmd.com/read/29712861/hcmv-glycoprotein-b-subunit-vaccine-efficacy-mediated-by-nonneutralizing-antibody-effector-functions
#10
Cody S Nelson, Tori Huffman, Jennifer A Jenks, Eduardo Cisneros de la Rosa, Guanhua Xie, Nathan Vandergrift, Robert F Pass, Justin Pollara, Sallie R Permar
Human cytomegalovirus (HCMV) is the most common congenital infection worldwide, frequently causing hearing loss and brain damage in afflicted infants. A vaccine to prevent maternal acquisition of HCMV during pregnancy is necessary to reduce the incidence of infant disease. The glycoprotein B (gB) + MF59 adjuvant subunit vaccine platform is the most successful HCMV vaccine tested to date, demonstrating ∼50% efficacy in preventing HCMV acquisition in multiple phase 2 trials. However, the mechanism of vaccine protection remains unknown...
April 30, 2018: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29712656/the-artemisinin-derivative-artemisone-is-a-potent-inhibitor-of-human-cytomegalovirus-replication
#11
E Oiknine-Djian, Y Weisblum, A Panet, H N Wong, R K Haynes, D G Wolf
Human cytomegalovirus (HCMV) is a major cause of disease in immunocompromised individuals and the most common cause of congenital infection and neuro-sensorial disease. The expanding target populations for HCMV antiviral treatment along with the limitations of the currently available HCMV DNA polymerase inhibitors underscore the need for new antiviral agents with alternative modes of action. The anti-malarial artemisinin derivative artesunate was shown to inhibit HCMV in vitro , yet has demonstrated limited antiviral efficacy in vivo , prompting our search for more potent anti-HCMV artemisinin derivatives...
April 30, 2018: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/29710020/-a-15-year-old-girl-with-congenital-cytomegalovirus-infection-presenting-with-sensorineural-hearing-impairment-and-cerebral-while-matter-lesions-but-no-intellectual-disability
#12
Keiichi Nakagawa, Masato Kadoya, Hiroshi Matsumoto, Hiroyuki Moriuchi, Katsunori Ikewaki, Kenichi Kaida
A 15-year-old girl presented with non-progressive sensorineural hearing impairment in her right ear since her early childhood. She had normal intellectual development. When she was 15 years old, small deep white matter lesions around the lateral ventricles were incidentally detected in brain MRI studies through further investigation of auditory organs. Laboratory data including cerebrospinal fluid analysis and antibodies to aquaporin-4 or myelin-oligodendrocyte glycoprotein were normal. She was diagnosed as a congenital cytomegalovirus (CMV) infection based on the detection of CMV DNA from preserved umbilical cord tissue by real-time polymerase chain reaction...
April 28, 2018: Rinshō Shinkeigaku, Clinical Neurology
https://www.readbyqxmd.com/read/29709989/congenital-cytomegalovirus-pneumonitis-and-treatment-response-evaluation-using-viral-load-during-ganciclovir-therapy-a-case-report
#13
Minsoo Lee, Keiji Goishi, Yuka Torii, Yoshinori Ito, Hiroya Ono, Tomoko Mori, Naoyuki Kashiwa, Shinichi Hosokawa, Hiroyuki Shichino
Cytomegalovirus (CMV) is the most common cause of congenital infection. Pneumonitis is considered to be a rare manifestation although congenital CMV infection presents with various non-specific findings. Ganciclovir and valganciclovir are beneficial for improving neurodevelopmental sequelae and hearing outcome of congenital CMV infection, but treatment response evaluationis not well reported. We report a female case of congenital CMV infectionpresenting with pneumonitis, meningoencephalitis, and chorioretinitis...
April 27, 2018: Japanese Journal of Infectious Diseases
https://www.readbyqxmd.com/read/29706491/risk-factors-geographic-distribution-and-healthcare-burden-of-symptomatic-congenital-cytomegalovirus-infection-in-the-united-states-analysis-of-a-nationally-representative-database-2000-2012
#14
Kengo Inagaki, Chad Blackshear, April Palmer, Charlotte V Hobbs
OBJECTIVE: To assess risk factors, geographic distribution, length of stay, and total charges per case of symptomatic congenital cytomegalovirus infection (cCMV). STUDY DESIGN: We performed retrospective analyses of serial cross-sectional data using the Kids' Inpatient Database, a nationally representative sample of US pediatric hospital discharges, from 2000, 2003, 2006, 2009, and 2012. Symptomatic cCMV was identified via use of the International Classification of Diseases, Ninth Revision, Clinical Modification code 771...
April 26, 2018: Journal of Pediatrics
https://www.readbyqxmd.com/read/29705727/does-screening-for-congenital-cytomegalovirus-at-birth-improve-longer-term-hearing-outcomes
#15
REVIEW
Cathie Hilditch, Bianca Liersch, Nicola Spurrier, Emily J Callander, Celia Cooper, Amy K Keir
Currently, the diagnosis of congenital cytomegalovirus (cCMV) infection in most highly resourced countries is based on clinical suspicion alone. This means only a small proportion of cCMV infections are diagnosed. Identification, through either universal or targeted screening of asymptomatic newborns with cCMV, who would previously have gone undiagnosed, would allow for potential early treatment with antiviral therapy, ongoing audiological surveillance and early intervention if sensorineural hearing loss (SNHL) is identified...
April 28, 2018: Archives of Disease in Childhood
https://www.readbyqxmd.com/read/29705613/false-human-cytomegalovirus-igg-positivity-at-prenatal-screening
#16
Milena Furione, Antonella Sarasini, Alessia Arossa, Chiara Fornara, Daniele Lilleri, Laurent Perez, Maurizio Parea, Maurizio Zavattoni, Arsenio Spinillo, Piero Marone, Fausto Baldanti
BACKGROUND: An incorrect definition of immune status to human cytomegalovirus (HCMV) can lead to incorrect management of pregnant women. OBJECTIVES: Aims of the study were: i) to describe 10 cases of unconfirmed HCMV IgG-seroconversion in pregnancy; ii) to develop a panel of confirmatory tests to define HCMV serostatus; iii) to investigate the frequency of false IgG-positive results in pregnant women screened with the LIAISON® CMVIgGII automated assay. STUDY DESIGN: Blood samples from 10 pregnant women referred for HCMV IgG-seroconversion were examined to confirm/exclude a primary infection...
April 21, 2018: Journal of Clinical Virology: the Official Publication of the Pan American Society for Clinical Virology
https://www.readbyqxmd.com/read/29703574/closer-to-universal-newborn-screening-for-congenital-cytomegalovirus-infection-but-far-away-from-antiviral-therapy-in-all-infected-infants
#17
EDITORIAL
Shannon Ross, Sarah S Long, David W Kimberlin
No abstract text is available yet for this article.
April 24, 2018: Journal of Pediatrics
https://www.readbyqxmd.com/read/29700602/influence-of-sphingosine-1-phosphate-signaling-on-hcmv-replication-in-human-embryonal-lung-fibroblasts
#18
Anika Zilch, Christian Rien, Cynthia Weigel, Stefanie Huskobla, Brigitte Glück, Katrin Spengler, Andreas Sauerbrei, Regine Heller, Markus Gräler, Andreas Henke
The human cytomegalovirus (HCMV) is a common pathogen, which causes severe or even deadly diseases in immunocompromised patients. In addition, congenital HCMV infection represents a major health concern affecting especially the lung tissue of the susceptible individuals. Antivirals are a useful strategy to treat HCMV-caused diseases. However, all approved drugs target viral proteins but significant toxicity and an increasing resistance against these compounds have been observed. In infected cells, numerous host molecules have been identified to play important roles during HCMV replication...
April 26, 2018: Medical Microbiology and Immunology
https://www.readbyqxmd.com/read/29692984/the-potential-harm-of-cytomegalovirus-infection-in-immunocompetent-critically-ill-children
#19
Raidan Alyazidi, Srinivas Murthy, Jennifer A Slyker, Soren Gantt
Cytomegalovirus (CMV) is a ubiquitous infection that causes disease in congenitally infected children and immunocompromised patients. Although nearly all CMV infections remain latent and asymptomatic in immunologically normal individuals, numerous studies have found that systemic viral reactivation is common in immunocompetent critically ill adults, as measured by detection of CMV in the blood (viremia). Furthermore, CMV viremia is strongly correlated with adverse outcomes in the adult intensive care unit (ICU), including prolonged stay, duration of mechanical ventilation, and death...
2018: Frontiers in Pediatrics
https://www.readbyqxmd.com/read/29686064/protection-from-cytomegalovirus-viremia-following-glycoprotein-b-vaccination-is-not-dependent-on-neutralizing-antibodies
#20
Ilona Baraniak, Barbara Kropff, Lyn Ambrose, Megan McIntosh, Gary R McLean, Sylvie Pichon, Claire Atkinson, Richard S B Milne, Michael Mach, Paul D Griffiths, Matthew B Reeves
Human cytomegalovirus (HCMV) is an important pathogen in transplant patients and in congenital infection. Previously, we demonstrated that vaccination with a recombinant viral glycoprotein B (gB)/MF59 adjuvant formulation before solid organ transplant reduced viral load parameters post transplant. Reduced posttransplant viremia was directly correlated with antibody titers against gB consistent with a humoral response against gB being important. Here we show that sera from the vaccinated seronegative patients displayed little evidence of a neutralizing antibody response against cell-free HCMV in vitro...
April 23, 2018: Proceedings of the National Academy of Sciences of the United States of America
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