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https://www.readbyqxmd.com/read/28733466/the-reliability-of-the-american-community-survey-for-injury-surveillance
#1
Nathaniel Bell, Bo Cai
BACKGROUND: To evaluate the reliability and predictability of 49 socioeconomic indicators constructed from the annual and multiyear American Community Survey (ACS) data cycles for monitoring injury inequalities across the USA. METHODS: Cross-sectional analysis of the 2006-2013 annual and multiyear county-level ACS data cycles. Indicator reliability was assessed using the margin of error and coefficient of variation (CV). Overlapping multiyear data cycles were assessed for statistical dependence in the estimates...
August 2017: Injury Prevention: Journal of the International Society for Child and Adolescent Injury Prevention
https://www.readbyqxmd.com/read/28732082/osteosarcoma-enters-a-post-genomic-era-with-in-silico-opportunities-generation-of-the-high-dimensional-database-for-facilitating-sarcoma-biology-research-a-report-from-the-children-s-oncology-group-and-the-quadw-foundation
#2
Jason Glover, Tsz-Kwong Man, Donald A Barkauskas, David Hall, Tanya Tello, Mary Beth Sullivan, Richard Gorlick, Katherine Janeway, Holcombe Grier, Ching Lau, Jeffrey A Toretsky, Scott C Borinstein, Chand Khanna, Timothy M Fan
The prospective banking of osteosarcoma tissue samples to promote research endeavors has been realized through the establishment of a nationally centralized biospecimen repository, the Children's Oncology Group (COG) biospecimen bank located at the Biopathology Center (BPC)/Nationwide Children's Hospital in Columbus, Ohio. Although the physical inventory of osteosarcoma biospecimens is substantive (>15,000 sample specimens), the nature of these resources remains exhaustible. Despite judicious allocation of these high-value biospecimens for conducting sarcoma-related research, a deeper understanding of osteosarcoma biology, in particular metastases, remains unrealized...
2017: PloS One
https://www.readbyqxmd.com/read/28730679/weighing-in-on-international-growth-standards-testing-the-case-in-australian-preschool-children
#3
REVIEW
C L Pattinson, S L Staton, S S Smith, S G Trost, E F Sawyer, K J Thorpe
Overweight and obesity in preschool-aged children are major health concerns. Accurate and reliable estimates of prevalence are necessary to direct public health and clinical interventions. There are currently three international growth standards used to determine prevalence of overweight and obesity, each using different methodologies: Center for Disease Control (CDC), World Health Organization (WHO) and International Obesity Task Force (IOTF). Adoption and use of each method were examined through a systematic review of Australian population studies (2006-2017)...
July 21, 2017: Obesity Reviews: An Official Journal of the International Association for the Study of Obesity
https://www.readbyqxmd.com/read/28730207/asymmetric-br%C3%A3-nsted-acid-catalysis-with-chiral-carboxylic-acids
#4
REVIEW
Chang Min, Daniel Seidel
Chiral Brønsted acids have found widespread applications as organocatalysts. Weakly acidic species such as diols and (thio)ureas, typically classified as hydrogen bonding catalysts, as well as stronger phosphoric acids, have proven to be highly effective in catalyzing a wide range of asymmetric transformations. In contrast, the use of chiral carboxylic acids as Brønsted acid catalysts is much less developed but has recently garnered increased attention. Given that their pKa's generally lie between those of typical hydrogen bond donors and chiral phosphoric acids, chiral carboxylic acids provide the opportunity to activate a different set of substrates requiring intermediate catalyst acidity...
July 21, 2017: Chemical Society Reviews
https://www.readbyqxmd.com/read/28730142/taming-parasites-by-tailoring-them
#5
Bingjian Ren, Nishith Gupta
The next-generation gene editing based on CRISPR (clustered regularly interspaced short palindromic repeats) has been successfully implemented in a wide range of organisms including some protozoan parasites. However, application of such a versatile game-changing technology in molecular parasitology remains fairly underexplored. Here, we briefly introduce state-of-the-art in human and mouse research and usher new directions to drive the parasitology research in the years to come. In precise, we outline contemporary ways to embolden existing apicomplexan and kinetoplastid parasite models by commissioning front-line gene-tailoring methods, and illustrate how we can break the enduring gridlock of gene manipulation in non-model parasitic protists to tackle intriguing questions that remain long unresolved otherwise...
2017: Frontiers in Cellular and Infection Microbiology
https://www.readbyqxmd.com/read/28724420/legal-access-to-medications-a-threat-to-brazil-s-public-health-system
#6
Ana Luiza Chieffi, Rita De Cassia Barata Barradas, Moisés Golbaum
BACKGROUND: In Brazil, health is fundamental human right guaranteed by the Constitution of 1988, which created the Brazilian Universal Health System (Sistema Único de Saúde - SUS). The SUS provides medications for outpatient care via policy of pharmaceutical assistance (PA) programmes. Despite the advances in PA policies which include the improvement in access to medications, there has been a significant increase in lawsuits related to health products and services. This study aimed to characterize the medication processes filed between 2010 and 2014 against the Secretary of State for Health of São Paulo (State Health Department of São Paulo - SES/SP), in Brazil, following PA policies...
July 19, 2017: BMC Health Services Research
https://www.readbyqxmd.com/read/28723504/active-surveillance-for-small-renal-masses-when-less-is-more
#7
REVIEW
Benjamin T Ristau, Alexander Kutikov, Robert G Uzzo, Marc C Smaldone
CONTEXT: A marked increase in incidentally detected small renal masses (SRMs) has occurred over the past decade. Active surveillance (AS) has emerged as an initial management option for these patients. OBJECTIVE: (1) To determine selection criteria, assess appropriate imaging modalities and surveillance frequencies, and define triggers for delayed intervention (DI) for patients on AS. (2) To describe oncologic outcomes for patients on AS protocols. EVIDENCE ACQUISITION: The PubMed database was queried for English language articles using the keywords "surveillance" and "renal mass" or "renal cell carcinoma" or "kidney cancer...
December 15, 2016: European Urology Focus
https://www.readbyqxmd.com/read/28718975/pyrene-mo-shuffle-controlling-excited-state-and-redox-properties-by-changing-the-nature-of-the-frontier-orbitals
#8
Julia Merz, Julian Fink, Alexandra Friedrich, Ivo Krummenacher, Hamad Al Mamari, Sabine Lorenzen, Martin Hähnel, Antonius Eichhorn, Michael Moos, Marco Holzapfel, Holger Braunschweig, Christoph Lambert, Andreas Steffen, Lei Ji, Todd B Marder
We show that by judicious choice of substituents at the 2,7-positions of pyrene, the frontier orbital order of pyrene can be modified, giving enhanced control over the nature and properties of the photoexcited states and the redox potentials. Specifically, we introduced a julolidine-like moiety and Bmes2 (mes = 2,4,6-Me3C6H2) as very strong donor (D) and acceptor (A), respectively, giving 2,7-D-π-D- and unsymmetric 2,7-D-π-A-pyrene derivatives, in which the donor destabilizes the HOMO-1 and the acceptor stabilizes the LUMO+1 of the pyrene core...
July 18, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/28718631/a-copper-ii-paddlewheel-metal-organic-framework-with-exceptional-hydrolytic-stability-and-selective-adsorption-and-detection-ability-of-aniline-in-water
#9
Ya Chen, Bin Wang, Xiaoqing Wang, Lin-Hua Xie, Jinping Li, Yabo Xie, Jian-Rong Jeff Li
Copper(II) paddlewheel based metal-organic frameworks (CP-MOFs) represent a unique subclass of MOFs with highly predictable porous structures, facile syntheses, and functional open metal sites. However, lack of high hydrolytic stability is an obstacle for CP-MOFs in many practical applications. In this work, we report a new CP-MOF, [Cu4(tdhb)] (BUT-155), which is constructed from a judiciously designed carboxylate ligand with high coordination connectivity (octatopic), abundant hydrophobic substituents (six methyl groups), and substituent constrained geometry (tetrahedral backbone), tdhb8- (H8tdhb = 3,3',5,5'-tetra(3,5-dicarboxyphenyl)-2,2',4,4',6,6'-hexamethylbiphenyl))...
July 18, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28715208/highly-stereoselective-synthesis-of-tetrasubstituted-acyclic-all-carbon-olefins-via-enol-tosylation-and-suzuki%C3%A2-miyaura-coupling
#10
Beryl X Li, Diane N Le, Kyle A Mack, Andrew McClory, Ngiap-Kie Lim, Theresa Cravillion, Scott Savage, Chong Han, David B Collum, Haiming Zhang, Francis Gosselin
A highly stereocontrolled synthesis of tetrasubstituted acyclic all-carbon olefins has been developed via a stereoselective enolization and tosylate formation, followed by a palladium-catalyzed Suzuki‒Miyaura cross-coupling of the tosylates and pinacol boronic esters in the presence of Pd(OAc)2/RuPhos catalytic system. Both the enol tosylation and Suzuki‒Miyaura coupling reactions tolerate an array of electronically and sterically diverse substituents and generate high yield and stereoselectivity of the olefin products...
July 17, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/28713177/nitsche-s-method-for-helmholtz-problems-with-embedded-interfaces
#11
Zilong Zou, Wilkins Aquino, Isaac Harari
In this work, we use Nitsche's formulation to weakly enforce kinematic constraints at an embedded interface in Helmholtz problems. Allowing embedded interfaces in a mesh provides significant ease for discretization, especially when material interfaces have complex geometries. We provide analytical results that establish the well-posedness of Helmholtz variational problems and convergence of the corresponding finite element discretizations when Nitsche's method is used to enforce kinematic constraints. As in the analysis of conventional Helmholtz problems, we show that the inf-sup constant remains positive provided that the Nitsche's stabilization parameter is judiciously chosen...
May 18, 2017: International Journal for Numerical Methods in Engineering
https://www.readbyqxmd.com/read/28713099/-giving-medico-legal-opinions-in-cases-with-suspicion-of-medical-mistake-part-1-between-medicine-and-justice
#12
Czesław Chowaniec, Małgorzata Chowaniec, Mateusz Wilk
Creating medico-legal opinion is a sophisticated investigative, analytical, decision-making and creative process. Forensic medicine specialist in cooperation with clinical medicine consultants, on the basis of evidence analysis, which was gathered during procedures and contained in the acts has to create an objective and essential opinion. This opinion is a vital, very important and irreplaceable proof in every case. Judicial body consults with forensic medicine specialist or specialists if there are circumstances for settlement of which there is a need of classified informations - art...
2017: Wiadomości Lekarskie: Organ Polskiego Towarzystwa Lekarskiego
https://www.readbyqxmd.com/read/28707416/engaging-the-terminal-promoting-halogen-bonding-interactions-with-uranyl-oxo-atoms
#13
Korey P Carter, Mark Kalaj, Robert Gian Surbella Iii, Lucas C Ducati, Jochen Autschbach, Christopher L Cahill
Engaging the nominally terminal oxo atoms of the linear uranyl (UO22+) cation in non-covalent interactions represents both a significant challenge and opportunity within the field of actinide hybrid materials. We have developed an approach for promoting oxo atom participation in a range of non-covalent interactions through judicious choice of electron donating equatorial ligands and appropriately polarizable halogen-donor atoms. As such, we have generated a family of uranyl hybrid materials based on a combination of 2,5-dihalobenzoic acid and aromatic, chelating N-donor ligands...
July 13, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/28704304/arterial-tree-anomalies-in-patients-with-clubfoot-an-investigation-carried-out-at-soba-university-hospital
#14
Samir Shaheen, Mustafa E H Bahar, Almigdad H A Mohammed, Sara F A Elbadri, Ashok Johari
Vascular deficiencies and reduced perfusion of the anterior tibial artery and the dorsalis pedis artery were suggested as causes of congenital talipes equino varus (CTEV). In this study, we assessed the prevalence of arterial abnormalities in patients with CTEV (50 patients; 74 feet) compared with a normal control group (16 patients; 32 feet) by Doppler ultrasound and Ankle Brachial Index. The flow was normal in the control group and was deficient in 39.19% of clubfoot patients. In severe clubfoot cases, the deficiency was found to an extent of 76...
July 12, 2017: Journal of Pediatric Orthopedics. Part B
https://www.readbyqxmd.com/read/28700367/open-adoption-placement-by-birth-mothers-in-their-twenties
#15
Lynn B Clutter
PURPOSE: The purpose of this study was to summarize birth mothers' descriptions of unplanned pregnancy experienced in their twenties and how open adoption influenced their lives. STUDY DESIGN AND METHODS: Naturalistic inquiry was used with purposive sampling from one agency and telephone interviews of women who experienced unplanned pregnancy in their twenties and relinquishment through open adoption. Recorded, transcribed, and deidentified interviews were analyzed for qualitative themes...
July 11, 2017: MCN. the American Journal of Maternal Child Nursing
https://www.readbyqxmd.com/read/28697159/outpatient-parenteral-antimicrobial-therapy-and-judicious-use-of-pediatric-emergency-resources
#16
Michael Xu, Quynh Doan
BACKGROUND: Pediatric returns to the emergency department (RTED) vary between 3% and 13% of the total ED volume of visits. However, the incidence and contribution of scheduled RTED on pediatric emergency department (PED) utilization is less clear. Antimicrobial stewardship programs on inpatient wards have been shown to improve judicious use of outpatient parenteral antimicrobial therapy (OPAT) in upon discharge. The implementation of such programs in PEDs has yet to be reported. The objectives of this study are to quantify the burden of scheduled RTED for OPAT on PED utilization and to examine how frequently OPAT use are supported by published practice standards for 3 common pediatric infections-cellulitis, pneumonia, and urinary tract infections...
July 11, 2017: Pediatric Emergency Care
https://www.readbyqxmd.com/read/28696457/control-of-the-light-response-in-supramolecular-metallopolymeric-gels-by-tuning-the-coordination-metal
#17
Etienne Borré, Jean-François Stumbé, Stéphane Bellemin-Laponnaz, Matteo Mauro
Two novel supramolecular metallo-heteropolymers bearing a photo-isomerizable telechelic bis-terpyridine ligand and either Fe(ii) or Co(ii) coordination metal were synthesized. Both polymers induced gelation of organic solvents at a concentration as low as 0.12 wt% yielding thixotropic gels. Judicious choice of the electronic and photophysical properties of both ditopic ligand and metal ion enabled to achieve control over photomechanical response in supramolecular organogels upon UV light irradiation through molecular design...
July 11, 2017: Chemical Communications: Chem Comm
https://www.readbyqxmd.com/read/28691774/bite-mark-analysis-in-foodstuffs-and-inanimate-objects-and-the-underlying-proofs-for-validity-and-judicial-acceptance
#18
Fernando Rivera-Mendoza, Stella Martín-de-Las-Heras, Pablo Navarro-Cáceres, Gabriel M Fonseca
Even though one of the first bite mark cases was Doyle v. State in 1954 (a bitten cheese case), the research has focused on bite marks inflicted in human skin. As published Papers, Case Reports, or Technical Notes can constitute precedents which are relied upon in making the legal arguments and a considerable amount of case law exists in this area, we present a systematic review on bite mark analysis in foodstuffs and inanimate objects and their underlying proofs for validity and judicial acceptance according to Daubert rulings...
July 10, 2017: Journal of Forensic Sciences
https://www.readbyqxmd.com/read/28688829/risk-factors-for-hospital-acquisition-of-trimethoprim-sulfamethoxazole-resistant-stenotrophomonas-maltophilia-in-adults-a-matched-case-control-study
#19
Ching-Hsun Wang, Jung-Chung Lin, Feng-Yee Chang, Ching-Mei Yu, Wei-San Lin, Kuo-Ming Yeh
BACKGROUND/PURPOSE: The emergence of trimethoprim-sulfamethoxazole resistant Stenotrophomonas maltophilia (TSRSM) represents a serious threat to patients. The aim of current study was to identify risk factors associated with hospital-acquired TSRSM occurrence in adult inpatients. METHODS: We conducted a matched case-control study in Tri-Service General Hospital, Taipei, Taiwan. From January 2014 through June 2015, case patients with TSRSM and control patients with trimethoprim-sulfamethoxazole susceptible S...
June 28, 2017: Journal of Microbiology, Immunology, and Infection, Wei Mian Yu Gan Ran za Zhi
https://www.readbyqxmd.com/read/28687464/antibiotic-stewardship-in-the-retail-clinic-setting-implementation-in-1100-clinics-nationwide
#20
Jennifer M Polinski, Sandra L Harmon, Kimberly J Henderson, Tobias Barker, Andrew Sussman, Nancy J Gagliano
In light of increasing antibiotic resistance and a slowed antibiotic development pipeline, stewardship is more urgent than ever. To date, most stewardship guidelines and best practice recommendations for implementation focus on local or regional health care organizations. CVS MinuteClinic has implemented a consistent, evidence-based stewardship approach in its >1100 clinics in 33 states. The approach is associated with higher quality antibiotic use than that in primary care practices and emergency departments...
July 4, 2017: Healthcare
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