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https://www.readbyqxmd.com/read/28230886/thermolysis-and-radiofluorination-of-diaryliodonium-salts-derived-from-anilines
#1
Ethan J Linstad, Amy L Vāvere, Bao Hu, Jayson J Kempinger, Scott E Snyder, Stephen G DiMagno
Aniline-derived diaryliodonium salts were synthesized and functionalized in good to excellent yields by judicious utilization of electron-withdrawing protecting groups. This simple approach opens another route to radiolabeling amino arenes in relatively complex molecules, such as flutemetamol.
February 23, 2017: Organic & Biomolecular Chemistry
https://www.readbyqxmd.com/read/28225845/-judicial-institutions-of-medical-experts
#2
Roberto Lm Godoy
This article considers the evolutive process that judicial organisms of medical experts have experienced in Argentina since their creation and formulates a proposal for its adequacy and modernization. Due to multiple and various evolutive factors, judicial organisms managing medicolegal expert activities show, nowadays, signals that a structural and dynamic reform is needed. They remain as organizational units of Public Administration and their effectiveness and efficiency depends not only of a scientific criteria but a managing one...
May 2016: Vertex: Revista Argentina de Psiquiatriá
https://www.readbyqxmd.com/read/28225697/who-should-ration
#3
Philip M Rosoff
A principal component of physician decision making is judging what interventions are clinically appropriate. Due to the inexorable and steady increase of health care costs in the US, physicians are constantly being urged to exercise judicious financial stewardship with due regard for the financial implications of what they prescribe. When applied on a case-by-case basis, this otherwise reasonable approach can lead to either inadvertent or overt and arbitrary restriction of interventions for some patients rather than others on the basis of clinically irrelevant characteristics such as ethnicity, gender, age, or skin color...
February 1, 2017: AMA Journal of Ethics
https://www.readbyqxmd.com/read/28224437/baseline-hbv-load-increases-the-risk-of-anti-tuberculous-drug-induced-hepatitis-flares-in-patients-with-tuberculosis
#4
Chun-Hui Zhu, Man-Zhi Zhao, Guang Chen, Jun-Ying Qi, Jian-Xin Song, Qin Ning, Dong Xu
Hepatitis associated anti-tuberculous treatment (HATT) has been a main obstacle in managing patients co-infected with Mycobacterium tuberculosis and hepatitis B virus (HBV). Therefore, we evaluated the factors related to the severity of adverse effects during HATT, especially those associated with liver failure. A retrospective study was carried out at Tongji Hospital from 2007 to 2012. Increases in serum transaminase levels of >3, 5, and 10 times the upper limit of normal (ULN) were used to define liver damage as mild, moderate, and severe, respectively...
February 2017: Journal of Huazhong University of Science and Technology. Medical Sciences
https://www.readbyqxmd.com/read/28224148/hypercrosslinked-porous-polymer-materials-design-synthesis-and-applications
#5
REVIEW
Liangxiao Tan, Bien Tan
Hypercrosslinked polymers (HCPs) are a series of permanent microporous polymer materials initially reported by Davankov, and have received an increasing level of research interest. In recent years, HCPs have experienced rapid growth due to their remarkable advantages such as diverse synthetic methods, easy functionalization, high surface area, low cost reagents and mild operating conditions. Judicious selection of monomers, appropriate length crosslinkers and optimized reaction conditions yielded a well-developed polymer framework with an adjusted porous topology...
February 22, 2017: Chemical Society Reviews
https://www.readbyqxmd.com/read/28220867/other-regarding-attention-focus-modulates-third-party-altruistic-choice-an-fmri-study
#6
Bastian David, Yang Hu, Frank Krüger, Bernd Weber
Third-party altruistic decision-making has been shown to be modulated by other-regarding attention (e.g., focusing on the offender's crime or the victim's situation especially in judicial judgment). However, the neural mechanisms underlying this modulation remain poorly understood. In this fMRI study, participants voluntarily decided if they wanted to punish the first-party offender or help the second-party victim using their own monetary endowment in an unfair context. Particularly, before deciding they were asked to focus on the (un)fairness of the offender proposing the offer (offender-focused block, OB), the feeling of the victim receiving this offer (victim-focused block, VB), or without any specific focus (baseline block, BB)...
February 21, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28219967/expert-witness-participation-in-civil-and-criminal-proceedings
#7
Stephan R Paul, Sandeep K Narang
The interests of the public and both the medical and legal professions are best served when scientifically sound and unbiased expert witness testimony is readily available in civil and criminal proceedings. As members of the medical community, patient advocates, and private citizens, pediatricians have ethical and professional obligations to assist in the civil and criminal judicial processes. This policy statement offers recommendations on advocacy, education, research, qualifications, standards, and ethical business practices all aimed at improving expert testimony...
February 20, 2017: Pediatrics
https://www.readbyqxmd.com/read/28219964/expert-witness-participation-in-civil-and-criminal-proceedings
#8
Sandeep K Narang, Stephan R Paul
The interests of the public and both the medical and legal professions are best served when scientifically sound and unbiased expert witness testimony is readily available in civil and criminal proceedings. As members of the medical community, patient advocates, and private citizens, pediatricians have ethical and professional obligations to assist in the civil and criminal judicial processes. This technical report explains how the role of the expert witness differs in civil and criminal proceedings, legal and ethical standards for expert witnesses, and strategies that have been employed to deter unscientific and irresponsible testimony...
February 20, 2017: Pediatrics
https://www.readbyqxmd.com/read/28218409/development-of-haemostatic-decontaminants-for-treatment-of-wounds-contaminated-with-chemical-warfare-agents-3-evaluation-of-in-vitro-topical-decontamination-efficacy-using-damaged-skin
#9
Helen L Lydon, Charlotte A Hall, Christopher H Dalton, J Kevin Chipman, John S Graham, Robert P Chilcott
Previous studies have demonstrated that haemostatic products with an absorptive mechanism of action retain their clotting efficiency in the presence of toxic materials and are effective in decontaminating chemical warfare (CW) agents when applied to normal, intact skin. The purpose of this in vitro study was to assess three candidate haemostatic products for effectiveness in the decontamination of superficially damaged porcine skin exposed to the radiolabelled CW agents, soman (GD), VX and sulphur mustard (HD)...
February 20, 2017: Journal of Applied Toxicology: JAT
https://www.readbyqxmd.com/read/28216782/indian-psychiatric-society-survey-on-clinical-practice-guidelines
#10
Sandeep Grover, Ajit Avasthi
AIM: This survey aimed to assess the utility of the earlier published clinical practice guidelines (CPGs) by IPS and to understand the expectations of members of Indian Psychiatric Society from the proposed revised CPGs. In addition, the survey also evaluated the current level of practice of psychiatry in terms of availability of different investigation facilities, prescription patterns in terms of use of polypharmacy, and competence in carrying out certain nonpharmacological treatments...
January 2017: Indian Journal of Psychiatry
https://www.readbyqxmd.com/read/28215168/contributions-of-the-interaction-between-dietary-protein-and-gut-microbiota-to-intestinal-health
#11
Ning Ma, Yanan Tian, Yi Wu, Xi Ma
There is growing recognition that composition and metabolic activity of the gut microbiota can be modulated by the dietary proteins which in turn impact health. The amino acid composition and digestibility of proteins, which are influenced by its source and amount of intake, play a pivotal role in determining the microbiota. Reciprocally, it appears that the gut microbiota is also able to affect protein metabolism which give rise to the view that function between the microbiota and protein can proceed in both directions...
February 16, 2017: Current Protein & Peptide Science
https://www.readbyqxmd.com/read/28213874/disease-burden-of-human-papillomavirus-infection-in-the-netherlands-1989-2014-the-gap-between-females-and-males-is-diminishing
#12
Scott A McDonald, Venetia Qendri, Johannes Berkhof, Hester E de Melker, Johannes A Bogaards
PURPOSE: Besides cervical cancer, HPV infection is linked to a multitude of diseases in both males and females, suggesting that vaccination programmes should be re-evaluated, with a judicious assessment made of the disease burden stratified by sex, age, and genotype. Projections of burden into the near future are also needed to provide a benchmark for evaluating the impact of vaccination programmes, and to assess the need for scaling-up preventive measures. METHODS: Using the disability-adjusted life-years (DALY) measure, we estimated the total HPV-associated disease burden in the Netherlands...
February 17, 2017: Cancer Causes & Control: CCC
https://www.readbyqxmd.com/read/28212933/surfactant-modified-chitosan-beads-for-cadmium-ion-adsorption
#13
Preeti Pal, Anjali Pal
Cadmium is one of the most toxic heavy metals, which has been classified as human carcinogen and tetratogen. In the present study chitosan (CS) beads are modified, in a novel way, using sodium dodecyl sulfate (SDS), a well known anionic surfactant. The concentration of SDS has been judiciously selected to form surfactant bilayers on CS surface. These modified beads are designated as surfactant-modified chitosan (SMCS) beads. The adsorbent has been characterized by scanning electron microscopy (SEM), Fourier transform infrared spectroscopy (FTIR), and X-ray diffraction (XRD)...
February 14, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28208999/experience-from-classroom-teaching-to-clinical-practice-regarding-shortened-dental-arch-sda-concept-among-dentists-a-questionnaire-study
#14
Ritu Gupta, Ravneet Malhi, Basavaraj Patthi, Ashish Singla, Chandrasheker Janakiram, Venisha Pandita, Monika Prasad, Jishnu Krishna Kumar
INTRODUCTION: Periodontal disease and dental caries are the common oral conditions which cause loss of teeth, mostly molars. This further leads to Shortening of Dental Arch and Shortened Dental Arch (SDA) concept provides the overall requirements of functional dentition at reduced cost without compromising the health. AIM: The aim of the present study was to assess the Knowledge, Attitude and Practices (KAP) towards SDA concept among dentists of Ghaziabad city (Uttar Pradesh, India)...
December 2016: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28208859/diphtheroids-important-nosocomial-pathogens
#15
Reshmi Chandran, Dinju Raj Puthukkichal, Ethel Suman, Shashidhar Kotian Mangalore
INTRODUCTION: Diphtheroids are defined as aerobic, non-sporulating, pleomorphic Gram-positive bacilli which are more uniformly stained than Corynebacterium diphtheriae, lack the metachromatic granules and are arranged in a palisade manner. They are usually commensals of the skin and mucous membranes. They differ from C.diphtheriae in biochemical rea-ctions as well as in toxin production. Since, they are usually found as commensals on the skin, they are often considered as mere contaminants when isolated from clinical samples...
December 2016: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28205643/optical-switching-using-transition-from-dipolar-to-charge-transfer-plasmon-modes-in-ge2sb2te5-bridged-metallodielectric-dimers
#16
Arash Ahmadivand, Burak Gerislioglu, Raju Sinha, Mustafa Karabiyik, Nezih Pala
Capacitive coupling and direct shuttling of charges in nanoscale plasmonic components across a dielectric spacer and through a conductive junction lead to excitation of significantly different dipolar and charge transfer plasmon (CTP) resonances, respectively. Here, we demonstrate the excitation of dipolar and CTP resonant modes in metallic nanodimers bridged by phase-change material (PCM) sections, material and electrical characteristics of which can be controlled by external stimuli. Ultrafast switching (in the range of a few nanoseconds) between amorphous and crystalline phases of the PCM section (here Ge2Sb2Te5 (GST)) allows for designing a tunable plasmonic switch for optical communication applications with significant modulation depth (up to 88%)...
February 16, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28198732/intensive-blood-pressure-lowering-in-chronic-kidney-disease-the-time-has-come
#17
Marcel Ruzicka, Swapnil Hiremath
PURPOSE OF REVIEW: Release of the findings from the Systolic Blood Pressure Intervention Trial has resulted in a renewed examination of intensive blood pressure (BP) lowering. Only a few national hypertension guidelines (Canada and Australia) have changed recommendations, but considerable heterogeneity still exists with respect to the patient population to whom intensive BP lowering may apply. RECENT FINDINGS: There is fairly robust evidence that lower BP targets in nondiabetic chronic kidney disease (CKD) results in a decrease in heart failure and mortality...
February 13, 2017: Current Opinion in Nephrology and Hypertension
https://www.readbyqxmd.com/read/28195706/piezoelectric-micro-and-nanostructured-fibers-fabricated-from-thermoplastic-nanocomposites-using-a-fiber-drawing-technique-comparative-study-and-potential-applications
#18
Xin Lu, Hang Qu, Maksim Skorobogatiy
We report an all-polymer flexible piezoelectric fiber that uses both judiciously chosen geometry and advanced materials in order to enhance fiber piezoelectric response. The microstructured/nanostructured fiber features a soft hollow polycarbonate core surrounded by a spiral multilayer cladding consisting of alternating layers of piezoelectric nanocomposites (polyvinylidene enhanced with BaTiO3, PZT, or CNT) and conductive polymer (carbon-filled polyethylene). The conductive polymer layers serve as two electrodes, and they also form two spatially offset electric connectors on the fiber surface designed for the ease of connectorization...
February 14, 2017: ACS Nano
https://www.readbyqxmd.com/read/28195689/non-swelling-click-crosslinked-gelatin-and-peg-hydrogels-with-tunable-properties-using-pluronic-linkers
#19
Vinh X Truong, Kelly M Tsang, John S Forsythe
Swelling of hydrogels leads to a decrease in mechanical performance coupled with complications in solute diffusion. In addition, hydrogel swelling affects patient safety in biomedical applications such as compression of tissue and fluid blockage. A conventional strategy for suppressing swelling is to introduce a thermoresponsive polymer with a lower critical solution temperature (LCST) within the network structure to counter the water uptake at elevated temperature. However, altering the gels mechanical strength via modification of the network structure often affects the water uptake behavior and thus a non-swelling platform with tunable mechanical properties suitable for various biomedical applications is desirable...
February 14, 2017: Biomacromolecules
https://www.readbyqxmd.com/read/28182801/acute-kidney-injury-in-patients-treated-with-vancomycin-and-piperacillin-tazobactam-a-retrospective-cohort-analysis
#20
W Cliff Rutter, Donna R Burgess, Jeffery C Talbert, David S Burgess
BACKGROUND: Empiric antimicrobial therapy often consists of the combination of gram-positive coverage with vancomycin (VAN) and gram-negative coverage, specifically an antipseudomonal beta-lactam such as piperacillin-tazobactam (PTZ). Nephrotoxicity is commonly associated with VAN therapy; however, recent reports show higher nephrotoxicity rates among patients treated with the combination of VAN and PTZ. OBJECTIVE: This study evaluated the effect of the VAN/PTZ combination on acute kidney injury (AKI) compared to VAN and PTZ monotherapies...
February 2017: Journal of Hospital Medicine: An Official Publication of the Society of Hospital Medicine
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