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https://www.readbyqxmd.com/read/29347440/cooling-beyond-the-boundary-value-in-supercritical-fluids-under-vibration
#1
D Sharma, A Erriguible, S Amiroudine
Supercritical fluids when subjected to simultaneous quench and vibration have been known to cause various intriguing flow phenomena and instabilities depending on the relative direction of temperature gradient and vibration. Here we describe a surprising and interesting phenomenon wherein temperature in the fluid falls below the imposed boundary value when the walls are quenched and the direction of vibration is normal to the temperature gradient. We define these regions in the fluid as sink zones, because they act like sink for heat within the fluid domain...
December 2017: Physical Review. E
https://www.readbyqxmd.com/read/29346330/formulation-of-poloxamers-for-drug-delivery
#2
REVIEW
Andrew M Bodratti, Paschalis Alexandridis
Poloxamers, also known as Pluronics®, are block copolymers of poly(ethylene oxide) (PEO) and poly(propylene oxide) (PPO), which have an amphiphilic character and useful association and adsorption properties emanating from this. Poloxamers find use in many applications that require solubilization or stabilization of compounds and also have notable physiological properties, including low toxicity. Accordingly, poloxamers serve well as excipients for pharmaceuticals. Current challenges facing nanomedicine revolve around the transport of typically water-insoluble drugs throughout the body, followed by targeted delivery...
January 18, 2018: Journal of Functional Biomaterials
https://www.readbyqxmd.com/read/29345409/how-i-investigate-monocytosis
#3
REVIEW
D T Lynch, J Hall, K Foucar
Monocytosis is a common finding that is caused by a wide variety of neoplastic and non-neoplastic conditions. The adequate evaluation of monocytosis involves the integration of laboratory data, morphology, clinical findings, and the judicious use of ancillary studies. We review the literature on monocytosis, including the 2017 revised 4th edition of the World Health Organization classification of hematopoietic neoplasms. We present a review of monocytosis with practical guidelines on how to approach both routine and challenging cases...
January 18, 2018: International Journal of Laboratory Hematology
https://www.readbyqxmd.com/read/29345138/a-four-step-synthesis-of-%C3%A2-%C3%AE-lycorane-via-pd0-catalyzed-double-c-sp2-h-c-sp3-h-arylation
#4
Ronan Rocaboy, David Dailler, Olivier Baudoin
An expedient synthesis of lycorine alkaloids is reported using a palladium(0)-catalyzed double C-X/C-H arylation as the key step. The selectivity of this reaction was controlled through the judicious choice of the two halogen atoms, and its generality was demonstrated through the construction of various substituted pyrrolophenanthridinones. A selective arene hydrogenation allowed for the completion of the synthesis of (±)-γ-lycorane in just four steps from commercially available precursors.
January 18, 2018: Organic Letters
https://www.readbyqxmd.com/read/29343899/flap-cover-in-a-patient-with-severe-haemophilia-type-a
#5
Narender Manickavachakan, Sunderraj Ellur, Vijay Thomas Mattyoo Joseph, Jonathan Victor, Cecil R Ross
Haemophilia A is a rare haematological disorder due to deficiency of Factor VIII, causing an abnormal coagulation response to injury. In severe haemophilia A, Factor VIII level is < 1%, often manifesting with spontaneous bleeding into joints. Judicious use of recombinant Factor VIII therapy to maintain adequate levels in the intraoperative, immediate and late post-operative periods, together with adjuvant pro-coagulants, can ensure a safe outcome following surgery. We describe the successful management of one such patient suffering from Marjolin's ulcer of the right gluteal region, who needed wide local excision followed by flap cover...
May 2017: Indian Journal of Plastic Surgery: Official Publication of the Association of Plastic Surgeons of India
https://www.readbyqxmd.com/read/29343557/dicer1-and-associated-conditions-%C3%A2-identification-of-at-risk-individuals-and-recommended-surveillance-strategies
#6
Kris Ann P Schultz, Gretchen M Williams, Junne Kamihara, Douglas R Stewart, Anne K Harris, Andrew J Bauer, Joyce Turner, Rachana Shah, Katherine Schneider, Kami Wolfe Schneider, Ann Garrity Carr, Laura A Harney, Shari Baldinger, A Lindsay Frazier, Daniel Orbach, Dominik T Schneider, David Malkin, Louis P Dehner, Yoav H Messinger, Ashley Hill
Pathogenic germline DICER1 variants cause a hereditary cancer predisposition syndrome with a variety of manifestations. In addition to conferring increased cancer risks for pleuropulmonary blastoma (PPB) and ovarian sex cord-stromal tumors, particularly Sertoli-Leydig cell tumor, individuals with pathogenic germline DICER1 variants may also develop lung cysts, cystic nephroma, renal sarcoma and Wilms tumor, nodular hyperplasia of the thyroid, nasal chondromesenchymal hamartoma, ciliary body medulloepithelioma, genitourinary embryonal rhabdomyosarcoma and brain tumors including pineoblastoma and pituitary blastoma...
January 17, 2018: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/29343286/diagnosis-and-management-of-transthyretin-familial-amyloid-polyneuropathy-in-japan-red-flag-symptom-clusters-and-treatment-algorithm
#7
REVIEW
Yoshiki Sekijima, Mitsuharu Ueda, Haruki Koike, Sonoko Misawa, Tomonori Ishii, Yukio Ando
Hereditary ATTR (ATTRm) amyloidosis (also called transthyretin-type familial amyloid polyneuropathy [ATTR-FAP]) is an autosomal-dominant, adult-onset, rare systemic disorder predominantly characterized by irreversible, progressive, and persistent peripheral nerve damage. TTR gene mutations (e.g. replacement of valine with methionine at position 30 [Val30Met (p.Val50Met)]) lead to destabilization and dissociation of TTR tetramers into variant TTR monomers, which form amyloid fibrils that deposit in peripheral nerves and various organs, giving rise to peripheral and autonomic neuropathy and several non-disease specific symptoms...
January 17, 2018: Orphanet Journal of Rare Diseases
https://www.readbyqxmd.com/read/29341305/plasmid-templated-control-of-dna-cyclodextrin-nanoparticle-morphology-through-molecular-vector-design-for-effective-gene-delivery
#8
Laura Gallego-Yerga, Juan M Benito, Laura Blanco-Fernández, María Martínez-Negro, Itziar Vélaz, Emilio Aicart, Elena Junquera, Carmen Ortiz Mellet, Conchita Tros de Ilarduya, Jose M Garcia Fernandez
Engineering self-assembled superstructures through complexation of plasmid DNA (pDNA) and single-isomer nanometric size macromolecules (molecular nanoparticles) is a promising strategy for gene delivery. Notably, the functionality and overall architecture of the vector can be precisely moulded at the atomic level by chemical tailoring, enabling unprecedented opportunities for structure/self-assembling/pDNA delivery relationship studies. Beyond this notion, by judiciously preorganizing the functional elements in cyclodextrin (CD)-based molecular nanoparticles through covalent dimerization, here we demonstrate that the morphology of the resulting nanocomplexes (CDplexes) can be tuned, from spherical to ellipsoidal, rod-type or worm-like nanoparticles, which makes it possible to gain understanding of their shape-dependent transfection properties...
January 17, 2018: Chemistry: a European Journal
https://www.readbyqxmd.com/read/29341236/induced-earthquakes-from-long-term-gas-extraction-in-groningen-the-netherlands-statistical-analysis-and-prognosis-for-acceptable-risk-regulation
#9
Charles Vlek
Recently, growing earthquake activity in the northeastern Netherlands has aroused considerable concern among the 600,000 provincial inhabitants. There, at 3 km deep, the rich Groningen gas field extends over 900 km2 and still contains about 600 of the original 2,800 billion cubic meters (bcm). Particularly after 2001, earthquakes have increased in number, magnitude (M, on the logarithmic Richter scale), and damage to numerous buildings. The man-made nature of extraction-induced earthquakes challenges static notions of risk, complicates formal risk assessment, and questions familiar conceptions of acceptable risk...
January 16, 2018: Risk Analysis: An Official Publication of the Society for Risk Analysis
https://www.readbyqxmd.com/read/29340102/the-impact-of-antibiotic-usage-on-the-efficacy-of-chemoimmunotherapy-is-contingent-on-the-source-of-tumor-reactive-t-cells
#10
Michal P Kuczma, Zhi-Chun Ding, Tao Li, Tsadik Habtetsion, Tingting Chen, Zhonglin Hao, Locke Bryan, Nagendra Singh, James N Kochenderfer, Gang Zhou
In recent years the combined use of chemotherapy and immunotherapy, collectively termed chemoimmunotherapy, has emerged as a promising treatment option for patients with cancer. Antibiotics are commonly used to reduce infection-related complications in patients undergoing chemotherapy. Intriguingly, accumulating evidence has implicated gut microbiota as a critical determinant of host antitumor immune responses, raising the question as to whether the use of broad-spectrum antibiotics would invariably diminish tumor response to chemoimmunotherapies...
December 19, 2017: Oncotarget
https://www.readbyqxmd.com/read/29338100/fixing-the-conformation-of-calix-4arenes-when-are-three-carbons-not-enough
#11
Susan Matthews, Samy Cecioni, John E O'Brien, Colin J MacDonald, David L Hughes, Garth A Jones, Stephen H Ashworth, Sébastien Vidal
Calix[4]arenes are unique macrocycles that through judicious functionalisation at the lower-rim can be either fixed in one of four conformations or remain conformationally flexible. Introduction of propynyl or propenyl groups unexpectedly provides a new possibility; a unidirectional conformational switch, with the 1,3-alternate and 1,2-alternate conformers switching to the partial cone conformation, whilst the cone conformation is unchanged, under standard experimental conditions. Using 1H NMR kinetic studies, rates of switching have been shown to be dependent on the starting conformation, upper-rim substituent, where reduction in bulk enables faster switching, solvent and temperature with 1,2-alternate conformations switching fastest...
January 16, 2018: Chemistry: a European Journal
https://www.readbyqxmd.com/read/29336548/judicious-design-of-cationic-cyclometalated-ir-iii-complexes-for-photochemical-energy-conversion-and-optoelectronics
#12
Isaac N Mills, Jonathan A Porras, Stefan Bernhard
The exponential growth in published studies on phosphorescent metal complexes has been triggered by their utilization in optoelectronics, solar energy conversion, and biological labeling applications. Very recent breakthroughs in organic photoredox transformations have further increased the research efforts dedicated to discerning the inner workings and structure-property relationships of these chromophores. Initially, the principal focus was on the Ru(II)-tris-diimine complex family. However, the limited photostability and lack of luminescence tunability discovered in these complexes prompted a broadening of the research to include 5d transition metal ions...
January 16, 2018: Accounts of Chemical Research
https://www.readbyqxmd.com/read/29334163/isomerically-pure-star-shaped-triphenylene-perylene-hybrids-involving-highly-extended-%C3%AF-conjugation
#13
Edurne Nuin, Vicent Lloret, Konstantin Amsharov, Frank Hauke, Gonzalo Abellán, Andreas Hirsch
The synthesis and characterization of a new type of a highly conjugated heterocyclic π-chromophore, consisting of a central triphenylene core fused with three perylene-monoimide units (star-shaped molecule) is described. By judicious bay-functionalization with tert-butylphenoxy substituents, aggregation was completely prevented in common organic solvents, allowing for a straightforward purification and, for the very first time, the complete separation of the constitutional isomers by HPLC. Both isomers can be easily distinguished by means of several conventional spectroscopic techniques...
January 15, 2018: Chemistry: a European Journal
https://www.readbyqxmd.com/read/29333666/stable-high-index-faceted-pt-skin-on-zigzag-like-ptfe-nanowires-enhances-oxygen-reduction-catalysis
#14
Mingchuan Luo, Yingjun Sun, Xu Zhang, Yingnan Qin, Mingqiang Li, Yingjie Li, Chunji Li, Yong Yang, Lei Wang, Peng Gao, Gang Lu, Shaojun Guo
Selectively exposing active surfaces and judiciously tuning the near-surface composition of electrode materials represent two prominent means of promoting electrocatalytic performance. Here, a new class of Pt3 Fe zigzag-like nanowires (Pt-skin Pt3 Fe z-NWs) with stable high-index facets (HIFs) and nanosegregated Pt-skin structure is reported, which are capable of substantially boosting electrocatalysis in fuel cells. These unique structural features endow the Pt-skin Pt3 Fe z-NWs with a mass activity of 2.11 A mg-1 and a specifc activity of 4...
January 15, 2018: Advanced Materials
https://www.readbyqxmd.com/read/29332508/battered-wives-or-dependent-mothers-negotiating-familial-ideology-in-law
#15
Chulani Kodikara
More than a decade after its passing, Sri Lanka's Prevention of Domestic Violence Act (PDVA) remains a remedy of last resort for female survivors of intimate partner violence, as there is little support to take on a rights-defined identity as a battered woman both inside and outside the courtroom. However, large numbers of women are accessing the Maintenance Act of 1999 to exit violent relationships without the censure and stigma that attaches to the PDVA. The key to understanding this phenomenon is to consider how familial ideology works in unpredictable ways within the Sri Lankan judicial system...
September 1, 2017: Violence Against Women
https://www.readbyqxmd.com/read/29332434/relationship-between-antimicrobial-resistance-programs-and-antibiotic-dispensing-for-upper-respiratory-tract-infection-an-analysis-of-australian-data-between-2004-and-2015
#16
Jianyun Wu, Daniel Taylor, Ludmila Ovchinikova, Aine Heaney, Tessa Morgan, Jonathan Dartnell, Rachel Holbrook, Lauren Humphreys, Lynn Weekes, Suzanne Blogg
Objective NPS MedicineWise aims to ensure that medicines are prescribed and used in a manner consistent with current evidence-based best practice. A series of nationwide educational and advertising interventions for general practitioners and consumers were implemented in Australia between 2009 and 2015 with the aim of reducing antibiotic prescriptions for upper respiratory tract infections (URTIs). The work described in this paper quantifies the change in antibiotic dispensing following these interventions...
January 1, 2018: Journal of International Medical Research
https://www.readbyqxmd.com/read/29331280/-jurisdictions-on-the-reimbursement-of-new-medical-technologies-by-public-health-insurance-a-systematic-review
#17
REVIEW
Patricia Ex, Susanne Felgner, Cornelia Henschke
BACKGROUND: In Germany reimbursement for new medical technologies is often enforced before a social court. It is likely that these judicial decisions also affect the sickness funds' decisions on requests for reimbursement and thus patient access to new technologies in general. OBJECTIVES: The aim of this study was to identify the technologies that have repeatedly generated court actions and whether these actions have been successful. The focus was on differences between sectors, technology groups and indications...
January 10, 2018: Zeitschrift Für Evidenz, Fortbildung und Qualität Im Gesundheitswesen
https://www.readbyqxmd.com/read/29330250/the-intersection-of-national-immigration-and-healthcare-policy
#18
Jeffrey Douaiher, Douglas J Inciarte, Edibaldo Silva
Immigration policy and health care policy remain principal undertakings of the federal government. The two have recently been pursued independently in the judicial and legislative arenas. Unbeknownst to many policymakers, however, national immigration policy and health care policy are linked in ways that, if unattended, could undermine the well-being of a significant portion of the US population, specifically medically underserved rural and urban populations. Using current data from a workforce report of the Association of American Colleges and the published literature, we demonstrate the significant impact that contemporary immigration policy directives may have on the number and distribution of international medical graduates who currently provide-and by the year 2025 will provide-a significant portion of primary health care in the United States, especially in underserved small urban and rural communities...
January 2018: Journal of the American Board of Family Medicine: JABFM
https://www.readbyqxmd.com/read/29328727/exact-time-dependent-exchange-correlation-potential-in-electron-scattering-processes
#19
Yasumitsu Suzuki, Lionel Lacombe, Kazuyuki Watanabe, Neepa T Maitra
We identify peak and valley structures in the exact exchange-correlation potential of time-dependent density functional theory that are crucial for time-resolved electron scattering in a model one-dimensional system. These structures are completely missed by adiabatic approximations that, consequently, significantly underestimate the scattering probability. A recently proposed nonadiabatic approximation is shown to correctly capture the approach of the electron to the target when the initial Kohn-Sham state is chosen judiciously, and it is more accurate than standard adiabatic functionals but ultimately fails to accurately capture reflection...
December 29, 2017: Physical Review Letters
https://www.readbyqxmd.com/read/29328290/design-of-narrowband-bragg-spectral-filters-in-subwavelength-grating-metamaterial-waveguides
#20
Jiří Čtyroký, Juan Gonzalo Wangüemert-Pérez, Pavel Kwiecien, Ivan Richter, Ján Litvik, Jens H Schmid, Íñigo Molina-Fernández, Alejandro Ortega-Moñux, Milan Dado, Pavel Cheben
Properties of reflection and transmission spectral filters based on Bragg gratings in subwavelength grating (SWG) metamaterial waveguides on silicon-on-insulator platform have been analyzed using proprietary 2D and 3D simulation tools based on Fourier modal method and the coupled-mode theory. We also demonstrate that the coupled Bloch mode theory can be advantageously applied to design of Bragg gratings in SWG waveguides. By combining different techniques, including judiciously positioning silicon loading segments within the evanescent field of the SWG waveguide and making use of its dispersion properties, it is possible to attain sub-nanometer spectral bandwidths for both reflection and transmission filters in the wavelength range of 1550 nm while keeping minimum structural features of the filters as large as 100 nm...
January 8, 2018: Optics Express
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