Liang Fang, Li Zhang, Mengran Wang, Yuhao He, Jiao Yang, Zengjin Huang, Ying Tan, Ke Fang, Jun Li, Zhiyuan Sun, Yanping Li, Yisen Tang, Weizheng Liang, Huanhuan Cui, Qionghua Zhu, Zhe Wu, Yiming Li, Yuhui Hu, Wei Chen
UNLABELLED: Epithelial-mesenchymal transition (EMT) is a fundamental cellular process frequently hijacked by cancer cells to promote tumor progression, especially metastasis. EMT is orchestrated by a complex molecular network acting at different layers of gene regulation. In addition to transcriptional regulation, posttranscriptional mechanisms may also play a role in EMT. Here, we performed a pooled CRISPR screen analyzing the influence of 1,547 RNA-binding proteins on cell motility in colon cancer cells and identified multiple core components of P-bodies (PB) as negative modulators of cancer cell migration...
March 4, 2024: Cancer Research