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https://www.readbyqxmd.com/read/27914787/elevation-of-yap-promotes-the-epithelial-mesenchymal-transition-and-tumor-aggressiveness-in-colorectal-cancer
#1
Hsiang-Hsi Ling, Chih-Chia Kuo, Bo-Xing Lin, Yen-Hua Huang, Cheng-Wei Lin
Tumor metastasis is the leading cause of death in cancer patients. Identifying metastatic biomarkers in tumor cells would help cancer diagnoses and the development of therapeutic targets. Yes-associated protein (YAP) plays an important role in organ development and has gained much attention in tumorigenesis. However, the role of YAP and the underlying mechanism in tumor metastasis of colorectal cancer (CRC) is still unclear. In this study, we generated metastatic 116-LM cells from the HCT116 CRC cell line. We found that the capacity for tumor aggressiveness was elevated in 116-LM cells and identified that YAP and its mRNA level were upregulated in 116-LM cells...
November 30, 2016: Experimental Cell Research
https://www.readbyqxmd.com/read/27898034/emerging-non-canonical-functions-and-regulation-by-p53-p53-and-stemness
#2
REVIEW
David J Olivos, Lindsey D Mayo
Since its discovery nearly 40 years ago, p53 has ascended to the forefront of investigated genes and proteins across diverse research disciplines and is recognized most exclusively for its role in cancer as a tumor suppressor. Levine and Oren (2009) reviewed the evolution of p53 detailing the significant discoveries of each decade since its first report in 1979. In this review, we will highlight the emerging non-canonical functions and regulation of p53 in stem cells. We will focus on general themes shared among p53's functions in non-malignant stem cells and cancer stem-like cells (CSCs) and the influence of p53 on the microenvironment and CSC niche...
November 26, 2016: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/27894095/microrna-182-drives-colonization-and-macroscopic-metastasis-via-targeting-its-suppressor-snai1-in-breast-cancer
#3
Yun Zhan, Xukun Li, Xiaoshuan Liang, Lin Li, Bangrong Cao, Baona Wang, Jianlin Ma, Fang Ding, Xiang Wang, Da Pang, Zhihua Liu
Metastasis is a multi-step process. Tumor cells occur epithelial-mesenchymal transition (EMT) to start metastasis, then, they need to undergo a reverse progression of EMT, mesenchymal-epithelial transition (MET), to colonize and form macrometastases at distant organs to complete the whole process of metastasis. Although microRNAs (miRNAs) functions in EMT process are well established, their influence on colonization and macrometastases formation remains unclear. Here, we established an EMT model in MCF-10A cells with SNAI1 overexpression, and characterized some EMT-related microRNAs...
November 24, 2016: Oncotarget
https://www.readbyqxmd.com/read/27878251/glyceraldehyde-3-phosphate-dehydrogenase-promotes-cancer-growth-and-metastasis-through-upregulation-of-snail-expression
#4
Kaiyan Liu, Zhenjie Tang, Amin Huang, Ping Chen, Panpan Liu, Jing Yang, Wenhua Lu, Jianwei Liao, Yicheng Sun, Shijun Wen, Yumin Hu, Peng Huang
Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) plays an important role in multiple cellular functions including metabolism and gene transcription. Our previous study showed that GAPDH expression was elevated in colon cancer and further upregulated in liver metastatic tissues, suggesting a possilbe role of GAPDH in promoting cancer metastasis. The present study was designed to investigate the underlying mechanism, using multiple experimental approaches including genetic silencing of GAPDH expression by short hairpin RNA (shRNA) and biochemcial/molecular analyses of the key events involved in glycolytic metabolism and epithelial-mesenchymal transition (EMT)...
November 18, 2016: International Journal of Oncology
https://www.readbyqxmd.com/read/27869122/celf1-is-a-central-node-in-post-transcriptional-regulatory-programmes-underlying-emt
#5
Arindam Chaudhury, Shebna Cheema, Joseph M Fachini, Natee Kongchan, Guojun Lu, Lukas M Simon, Tao Wang, Sufeng Mao, Daniel G Rosen, Michael M Ittmann, Susan G Hilsenbeck, Chad A Shaw, Joel R Neilson
The importance of translational regulation in tumour biology is increasingly appreciated. Here, we leverage polyribosomal profiling to prospectively define translational regulatory programs underlying epithelial-to-mesenchymal transition (EMT) in breast epithelial cells. We identify a group of ten translationally regulated drivers of EMT sharing a common GU-rich cis-element within the 3'-untranslated region (3'-UTR) of their mRNA. These cis-elements, necessary for the regulatory activity imparted by these 3'-UTRs, are directly bound by the CELF1 protein, which itself is regulated post-translationally during the EMT program...
November 21, 2016: Nature Communications
https://www.readbyqxmd.com/read/27862275/long-noncoding-rna-zfas1-promotes-the-progression-of-colonic-cancer-by-modulating-zeb1-expression
#6
Changyi Fang, Jianbao Zan, Ben Yue, Chenchen Liu, Chenglong He, Dongwang Yan
BACKGROUND AND AIM: Long non-coding RNA ZFAS1 (zinc finger antisense 1) is frequently amplified in hepatocellular carcinoma and promotes metastasis by increasing zinc finger E-box binding homeobox 1 (ZEB1), which can potentiate the progression of epithelial-to-mesenchymal transition (EMT). However, the expression pattern and role of ZFAS1 in colonic cancer remains unknown. The present study aimed to investigate the role of ZFAS1 and its clinical significance in colonic cancer. METHODS: Paired clinical colonic cancer tissue samples and clinicopathologic characteristics of 73 patients were analyzed...
November 11, 2016: Journal of Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/27837433/tlr4-mediated-galectin-1-production-triggers-epithelial-mesenchymal-transition-in-colon-cancer-cells-through-adam10-and-adam17-associated-lactate-production
#7
Ga Bin Park, Daejin Kim
Toll-like receptor 4 (TLR4) activation is a key contributor to the carcinogenesis of colon cancer. Overexpression of galectin-1 (Gal-1) also correlates with increased invasive activity of colorectal cancer. Lactate production is a critical predictive factor of risk of metastasis, but the functional relationship between intracellular lactate and Gal-1 expression in TLR4-activated colon cancer remains unknown. In this study, we investigated the underlying mechanism and role of Gal-1 in metastasis and invasion of colorectal cancer (CRC) cells after TLR4 stimulation...
November 12, 2016: Molecular and Cellular Biochemistry
https://www.readbyqxmd.com/read/27823633/inhibitory-effect-of-quercetin-on-colorectal-lung-metastasis-through-inducing-apoptosis-and-suppression-of-metastatic-ability
#8
Ji-Ye Kee, Yo-Han Han, Dae-Seung Kim, Jeong-Geon Mun, Jinbong Park, Mi-Young Jeong, Jae-Young Um, Seung-Heon Hong
BACKGROUND: Quercetin is a major dietary flavonoid found in a various fruits, vegetables, and grains. Although the inhibitory effects of quercetin have previously been observed in several types of cancer cells, the anti-metastatic effect of quercetin on colorectal metastasis has not been determined. PURPOSE: This study investigated whether quercetin exhibits inhibitory effect on colorectal lung metastasis. STUDY DESIGN: The effects of quercetin on cell viability, mitogen-activated protein kinases (MAPKs) activation, migration, invasion, epithelial-mesenchymal transition (EMT) and lung metastasis were investigated...
December 1, 2016: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
https://www.readbyqxmd.com/read/27783057/dissecting-the-heterogeneity-of-circulating-tumor-cells-in-metastatic-breast-cancer-going-far-beyond-the-needle-in-the-haystack
#9
REVIEW
Michela Bulfoni, Matteo Turetta, Fabio Del Ben, Carla Di Loreto, Antonio Paolo Beltrami, Daniela Cesselli
Although the enumeration of circulating tumor cells (CTC) defined as expressing both epithelial cell adhesion molecule and cytokeratins (EpCAM⁺/CK⁺) can predict prognosis and response to therapy in metastatic breast, colon and prostate cancer, its clinical utility (i.e., the ability to improve patient outcome by guiding therapy) has not yet been proven in clinical trials. Therefore, scientists are now focusing on the molecular characterization of CTC as a way to explore its possible use as a "surrogate" of tumor tissues to non-invasively assess the genomic landscape of the cancer and its evolution during treatment...
October 24, 2016: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/27742576/claudin-1-promotes-tnf-%C3%AE-induced-epithelial-mesenchymal-transition-and-migration-in-colorectal-adenocarcinoma-cells
#10
Ajaz A Bhat, Rizwan Ahmad, SrijayaPrakash B Uppada, Amar B Singh, Punita Dhawan
Epithelial-mesenchymal transition (EMT) is an important mechanism in cancer progression and malignancy including colorectal cancer (CRC). Importantly, inflammatory mediators are critical constituents of the local tumor environment and an intimate link between CRC progression and inflammation is now validated. We and others have reported key role of the deregulated claudin-1 expression in colon carcinogenesis including colitis-associated colon cancer (CAC). However, the causal association between claudin-1 expression and inflammation-induced colon cancer progression remains unclear...
October 11, 2016: Experimental Cell Research
https://www.readbyqxmd.com/read/27662663/stc2-promotes-the-epithelial-mesenchymal-transition-of-colorectal-cancer-cells-through-akt-erk-signaling-pathways
#11
Bing Chen, Xiao Zeng, Yu He, Xixi Wang, Ziwei Liang, Jingjing Liu, Peng Zhang, Hongxia Zhu, Ningzhi Xu, Shufang Liang
The STC2 protein involves in carcinogenesis and progression of many cancers. It remains unclear how STC2 regulates the epithelial-mesenchymal transition (EMT) process and colorectal cancer (CRC) development. Here we systematically investigated STC2-activated early occurrence of EMT and CRC cell migration in vitro, clinical associations of STC2 with CRC development and patient survival. The secretion and expression level of STC2 were both greatly increased in EMT cells and CRC cells compared with the normal epithelial NCM460 cells...
September 20, 2016: Oncotarget
https://www.readbyqxmd.com/read/27650539/the-other-face-of-mir-17-92a-cluster-exhibiting-tumor-suppressor-effects-in-prostate-cancer
#12
Richard Ottman, Jenna Levy, Grizzle E Williams, Ratna Chakrabarti
miR-17-92a cluster miRNAs are transcribed from a polycistronic transcription unit C13orf25 that generates six mature miRNAs, miR-17, miR-18a, miR-19a, miR-19b, miR-20a and miR-92a that are overexpressed in lung and colon cancers. Here we show that the expression of miR-17-92a miRNAs are reduced in cancerous prostate tissues compared to uninvolved areas and also in aggressive prostate cancer cells. Restoration of expression of all members of miR-17-92a cluster showed, decreased expression of cell cycle regulatory proteins cyclin D1 and SSH1; and LIMK1 and FGD4 of RhoGTPase signaling pathway...
September 16, 2016: Oncotarget
https://www.readbyqxmd.com/read/27641329/fermt1-mediates-epithelial-mesenchymal-transition-to-promote-colon-cancer-metastasis-via-modulation-of-%C3%AE-catenin-transcriptional-activity
#13
C-C Liu, D-L Cai, F Sun, Z-H Wu, B Yue, S-L Zhao, X-S Wu, M Zhang, X-W Zhu, Z-H Peng, D-W Yan
We previously demonstrated that fermitin family member 1 (FERMT1) was significantly overexpressed in colon cancer (CC) and associated with poor metastasis-free survival. This study aimed to investigate the precise role of FERMT1 in CC metastasis and the mechanism by which FERMT1 is involved in the epithelial-mesenchymal transition (EMT). Correlations between FERMT1 and EMT markers (E-cadherin, Slug, N-cadherin and β-catenin) were examined via immunohistochemistry in a cohort of CC tissues and adjacent normal colon mucosae...
September 19, 2016: Oncogene
https://www.readbyqxmd.com/read/27630122/tp53-drives-invasion-through-expression-of-its-%C3%AE-133p53%C3%AE-variant
#14
Gilles Gadea, Nikola Arsic, Kenneth Fernandes, Alexandra Diot, Sébastien M Joruiz, Samer Abdallah, Valerie Meuray, Stéphanie Vinot, Christelle Anguille, Judit Remenyi, Marie P Khoury, Philip R Quinlan, Colin A Purdie, Lee B Jordan, Frances V Fuller-Pace, Marion de Toledo, Maïlys Cren, Alastair M Thompson, Jean-Christophe Bourdon, Pierre Roux
TP53 is conventionally thought to prevent cancer formation and progression to metastasis, while mutant TP53 has transforming activities. However, in the clinic, TP53 mutation status does not accurately predict cancer progression. Here we report, based on clinical analysis corroborated with experimental data, that the p53 isoform Δ133p53β promotes cancer cell invasion, regardless of TP53 mutation status. Δ133p53β increases risk of cancer recurrence and death in breast cancer patients. Furthermore Δ133p53β is critical to define invasiveness in a panel of breast and colon cell lines, expressing WT or mutant TP53...
September 15, 2016: ELife
https://www.readbyqxmd.com/read/27629879/the-high-expression-of-long-non-coding-rna-pandar-indicates-a-poor-prognosis-for-colorectal-cancer-and-promotes-metastasis-by-emt-pathway
#15
Min Lu, Zhuo Liu, Bo Li, Gang Wang, Dechuan Li, Yuping Zhu
BACKGROUND: Long non-coding RNAs (lncRNAs) have been shown to have crucial regulatory roles in human cancer biology. LncRNA PANDAR is a novel identified lncRNA that was previously reported to be increased in various cancers; however, its effect in colorectal cancer (CRC) remains unknown. The aim of this study was to explore the expression and role of lncRNA PANDAR in CRC. METHODS: The expression of lncRNA PANDAR was examined in CRC samples and cell lines by qRT-PCR...
September 14, 2016: Journal of Cancer Research and Clinical Oncology
https://www.readbyqxmd.com/read/27613838/numb-like-numbl-downregulation-increases-tumorigenicity-cancer-stem-cell-like-properties-and-resistance-to-chemotherapy
#16
José M García-Heredia, Eva M Verdugo Sivianes, Antonio Lucena-Cacace, Sonia Molina-Pinelo, Amancio Carnero
NumbL, or Numb-like, is a close homologue of Numb, and is part of an evolutionary conserved protein family implicated in some important cellular processes. Numb is a protein involved in cell development, in cell adhesion and migration, in asymmetric cell division, and in targeting proteins for endocytosis and ubiquitination. NumbL exhibits some overlapping functions with Numb, but its role in tumorigenesis is not fully known. Here we showed that the downregulation of NumbL alone is sufficient to increase NICD nuclear translocation and induce Notch pathway activation...
August 23, 2016: Oncotarget
https://www.readbyqxmd.com/read/27613835/mechanism-of-suppressors-of-cytokine-signaling-1-inhibition-of-epithelial-mesenchymal-transition-signaling-through-ros-regulation-in-colon-cancer-cells-suppression-of-src-leading-to-thioredoxin-up-regulation
#17
Sung-Hoon Jung, Su-Min Kim, Choong-Eun Lee
Reactive oxygen species (ROS) participate in malignant progression of cancers including epithelial-mesenchymal transition (EMT). We have investigated the role of suppressors of cytokine signaling (SOCS)1 as an inhibitor of ROS-induced EMT using colon cancer cell lines transduced with SOCS1 and shSOCS1. Hydrogen peroxide treatment induced EMT features such as elevation of vimentin and Snail with a corresponding reduction of E-cadherin. The EMT markers are significantly decreased upon SOCS1 over-expression while increased under SOCS1 knock-down...
August 23, 2016: Oncotarget
https://www.readbyqxmd.com/read/27612479/upregulation-of-annexin-a1-expression-by-butyrate-in-human-melanoma-cells-induces-invasion-by-inhibiting-e-cadherin-expression
#18
Jimin Shin, In-Sung Song, Jhang Ho Pak, Sung-Wuk Jang
Epithelial to mesenchymal transition (EMT) is a critical step in the metastasis of epithelial cancer cells. Butyrate, which is produced from dietary fiber by colonic bacterial fermentation, has been reported to influence EMT. However, some studies have reported that butyrate promotes EMT, while others have reported an inhibitory effect. To clarify these controversial results, it is necessary to elucidate the mechanism by which butyrate can influence EMT. In this study, we examined the potential role of annexin A1 (ANXA1), which was previously reported to promote EMT in breast cancer cells, as a mediator of EMT regulation by butyrate...
September 10, 2016: Tumour Biology: the Journal of the International Society for Oncodevelopmental Biology and Medicine
https://www.readbyqxmd.com/read/27611932/exosomes-secreted-from-human-colon-cancer-cells-influence-the-adhesion-of-neighboring-metastatic-cells-role-of-microrna-210
#19
Elisabetta Bigagli, Cristina Luceri, Daniele Guasti, Lorenzo Cinci
Cancer-secreted exosomes influence tumor microenvironment and support cancer growth and metastasis. MiR-210 is frequently up-regulated in colorectal cancer tissues and correlates with metastatic disease. We investigated whether exosomes are actively released by HCT-8 colon cancer cells, the role of exosomal miR-210 in the cross-talk between primary cancer cells and neighboring metastatic cells and its contribution in regulating epithelial-mesenchymal transition (EMT) and mesenchymal-epithelial transition (MET)...
August 11, 2016: Cancer Biology & Therapy
https://www.readbyqxmd.com/read/27600678/bmi-1-promotes-the-invasion-and-migration-of-colon-cancer-stem-cells-through-the-downregulation-of-e-cadherin
#20
Zefeng Zhang, Xiaoling Bu, Hao Chen, Qiyi Wang, Weihong Sha
Metastasis and recurrence are the challenges of cancer therapy. Recently, mounting evidence has suggested that cancer stem cells (CSCs) and epithelial-mesenchymal transition (EMT) are critical factors in tumor metastasis and recurrence. The oncogene, Bmi-1, promotes the development of hematologic malignancies and many solid tumors. The aim of the present study was to elucidate the mechanisms through which Bmi-1 promotes the invasion and migration of colon CSCs (CCSCs) using the HCT116 colon cancer cell line...
October 2016: International Journal of Molecular Medicine
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