keyword
https://read.qxmd.com/read/38476758/case-report-a-rare-case-of-intramedullary-spinal-cord-abscess-with-brain-abscess-caused-by-klebsiella-pneumoniae-underwent-surgical-intervention
#21
Wenjuan Zhang, Xiangyu Guo, Xuejun Xu, Bing Deng
BACKGROUND: Intramedullary Spinal Cord Abscess (ISCA) is an uncommon infectious disease of the central nervous system. Since its first report in 1830, there have been very few documented cases associated with it. Here, we present a case of ISCA with cerebral abscess caused by Klebsiella pneumoniae. CASE PRESENTATION: A 55-year-old male patient presented with head and neck pain, fever, and left limb weakness for 5 days. The diagnosis of ISCA with brain abscess caused by Klebsiella pneumoniae was confirmed through sputum culture, cerebrospinal fluid gene test, pus culture, and magnetic resonance imaging (MRI) as well as computerized tomography (CT) scan...
2024: Frontiers in Surgery
https://read.qxmd.com/read/38476506/evaluation-of-pulmonary-function-tests-dyspnea-scores-and-antibody-levels-at-the-six-month-follow-up-of-patients-hospitalized-for-covid-19-pneumonia
#22
JOURNAL ARTICLE
Kadir Özmen, Mehmet Meral, Bugra Kerget, Elif Yılmazel Uçar, Leyla Sağlam, Murat Özmen
BACKGROUND: Coronavirus disease 2019 (COVID-19) causes various signs and symptoms, especially lung involvement, during acute infection and in the long term. In this study, we evaluated the follow-up results of patients with chronic COVID-19 over a 24-week period. METHODS: The study included a total of 100 post-COVID-19 patients (confirmed by real-time polymerase chain reaction (PCR) of a nasopharyngeal swab) who presented to the post-COVID-19 outpatient clinic with chronic COVID-19 symptoms 12 weeks after diagnosis, between April and June 2021...
March 2024: Curēus
https://read.qxmd.com/read/38476447/multiple-pulmonary-cavities-in-an-immunocompetent-patient-a-case-report-and-literature-review
#23
Zihan Guo, Anli Zuo, Xinyi Liu, Yunxiu Jiang, Shuran Yang, Degan Lu
Legionella pneumonia (LP) is a relatively uncommon yet well-known type of atypical community-acquired pneumonia (CAP). It is characterized by a rapid progression to severe pneumonia and can be easily misdiagnosed. In most patients, chest computed tomography (CT) showed patchy infiltration, which may progress to lobar infiltration or even lobar consolidation. While pulmonary cavities are commonly observed in immunocompromised patients with LP, they are considered rare in immunocompetent individuals. Herein, we present a case of LP in an immunocompetent patient with multiple cavities in both lungs...
2024: Frontiers in Medicine
https://read.qxmd.com/read/38476159/current-approach-to-dysphagia-a-review-focusing-on-esophageal-motility-disorders-and-their-treatment
#24
REVIEW
André Mascarenhas, Rui Mendo, Catarina O'Neill, Ana Rita Franco, Raquel Mendes, Inês Simão, José Pedro Rodrigues
BACKGROUND: Dysphagia is a prevalent condition which may severely impact the patient's quality of life. However, there are still lacking standardized therapeutic options for esophageal motility disorders. SUMMARY: Dysphagia is defined as a subjective sensation of difficulty swallowing which can result from oropharyngeal or esophageal etiologies. Regarding esophageal dysphagia, after excluding structural causes and esophageal mucosal lesions, high-resolution manometry (HRM) is the gold standard for the diagnosis of esophageal motility disorders...
December 2023: GE Portuguese Journal of Gastroenterology
https://read.qxmd.com/read/38471817/assessment-of-risk-adjusted-mortality-ratio-ramr-in-bloodstream-infections-using-all-patient-refined-diagnosis-related-groups-apr-drgs
#25
JOURNAL ARTICLE
Guillermo Maestro De La Calle, Jorge Vélez, Javier Mateo Flores, Noelia García Barrio, María Ángeles Orellana, Víctor Quirós-González, Carlos Lumbreras Bermejo, José Luis Bernal
OBJECTIVES: To calculate a risk-adjusted mortality ratio (RAMR) for bloodstream infections (BSIs) using all-patient refined diagnosis-related groups (APR-DRGs) and compare it with the crude mortality rate (CMR). METHODS: Retrospective observational study of prevalent BSI at our institution from January 2019 to December 2022. In-hospital mortality was adjusted with a binary logistic regression model adjusting for sex, age, admission type and mortality risk for the hospitalization episode according to the four severity levels of APR DRGs...
March 13, 2024: Journal of Antimicrobial Chemotherapy
https://read.qxmd.com/read/38471804/relevance-and-antimicrobial-resistance-profile-of-klebsiella-pneumoniae-in-neonatal-sepsis
#26
JOURNAL ARTICLE
Hui Ma, JingWen Xu, YanHong Zhang, RenYan Zhang, Jie Wu
BACKGROUND: Newborns are particularly susceptible to infection in hospitals, with neonatal sepsis being the most common infection symptom and the third leading cause of neonatal death. Klebsiella pneumoniae is a gram-negative bacterium of Enterobacteriaceae, which is a common pathogen of neonatal septicemia. In this study, we will analyze and evaluate the current status, clinical characteristics, and drug resistance of Klebsiella pneumoniae sepsis infection in Neonatal Intensive Care Unit (NICU), with the aim of providing effective basis for timely and accurate clinical diagnosis and treatment in clinical practice...
December 2024: Journal of Maternal-fetal & Neonatal Medicine
https://read.qxmd.com/read/38469308/case-report-successful-treatment-of-an-anti-d2r-and-dppx-antibody-associated-autoimmune-encephalitis-patient-with-high-dose-methylprednisolone-and-intravenous-immunoglobulin
#27
Zhangliang Lin, Feng Zhou, Lili Ni, Shiye Dong, Guoping Fu, Jiangman Zhao
BACKGROUND: Autoimmune encephalitis is a neurological condition caused by abnormal immune responses, manifesting as cognitive impairments, behavioral abnormalities, and seizures. Its diagnosis depends on the detecting neuronal surface antibodies in serum or cerebrospinal fluid. Despite recent advances in understanding, clinical recognition remains challenging, especially with rare antibodies such as anti-dopamine D2 receptor (D2R) and anti-dipeptidyl-peptidase-like protein 6 (DPPX) antibodies...
2024: Frontiers in Immunology
https://read.qxmd.com/read/38468399/postoperative-complications-of-surgery-for-cervical-spondylotic-myelopathy-with-and-without-athetoid-cerebral-palsy
#28
JOURNAL ARTICLE
Naohiro Tachibana, Nobuaki Michihata, Takeshi Oichi, Kosei Nagata, Hideki Nakamoto, Nozomu Ohtomo, Yuichi Yoshida, Koji Nakajima, Junya Miyahara, So Kato, Toru Doi, Yuki Taniguchi, Yoshitaka Matsubayashi, Sakae Tanaka, Hideo Yasunaga, Yasushi Oshima
STUDY DESIGN: Retrospective cohort study. OBJECTIVES: With the aging of the Japanese population, patients with athetoid cerebral palsy (ACP) are getting older, and the rate of surgery for CSM is increasing in ACP patients. However, postoperative complications of such surgery among adult patients with ACP have not been reported yet. We investigated postoperative complications of surgery for CSM with ACP and compared them with those of surgery for CSM without ACP using a national inpatient database of Japan...
March 11, 2024: Global Spine Journal
https://read.qxmd.com/read/38467994/cumulative-anticholinergic-burden-and-its-predictors-among-older-adults-with-alzheimer-s-disease-initiating-cholinesterase-inhibitors
#29
JOURNAL ARTICLE
Ashna Talwar, Satabdi Chatterjee, Jeffrey Sherer, Susan Abughosh, Michael Johnson, Rajender R Aparasu
BACKGROUND: Cumulative anticholinergic burden refers to the cumulative effect of multiple medications with anticholinergic properties. However, concomitant use of cholinesterase inhibitors (ChEIs) and anticholinergic burden can nullify the benefit of the treatment and worsen Alzheimer's disease (AD). A literature gap exists regarding the extent of the cumulative anticholinergic burden and associated risk factors in AD. Therefore, this study evaluated the prevalence and predictors of cumulative anticholinergic burden among patients with AD initiating ChEIs...
March 11, 2024: Drugs & Aging
https://read.qxmd.com/read/38465762/hypereosinophilic-syndrome-associated-with-multiple-thromboses-requiring-icu-admission-a-case-report
#30
JOURNAL ARTICLE
Islem Ouanes, Sarra Toumi, Yasser Ben Cheikh, Oussama Ben Rejeb, Nadia Mama
Hypereosinophilic syndrome (HES) is a leucoproliferative disorder, characterized by marked blood eosinophilia and organ damage due to tissue eosinophilia. Pulmonary involvement may lead to life-threatening acute respiratory failure and intensive care unit (ICU) admission. Association between eosinophilia and thromboembolism has been previously described. However, simultaneous venous and arterial thromboses are less reported. We report a case of a 25-year-old man, admitted to the ICU and developed acute respiratory failure, laboratory tests revealed hyperleukocytosis (39,700 /µL) with high eosinophil count (27393 /µl), Computed tomographic (CT) pulmonary angiography on admission showed a right pulmonary embolism and foci of splenic infarctions...
October 5, 2023: La Tunisie Médicale
https://read.qxmd.com/read/38465756/c-reactive-protein-in-the-early-diagnosis-of-pneumonia-complicating-severe-blunt-chest-trauma
#31
JOURNAL ARTICLE
Becem Trabelsi, Sahar Ghorbel, Rania Ben Rabeh, Mahdi Bouassida, Mechaal Ben Ali
INTRODUCTION: The early diagnosis of pneumonia following severe blunt chest trauma (SBCT) allows the early prescription of antibiotics and initiation of adequate supportive care. AIM: To assess the usefulness of C-reactive protein (CRP) in the early diagnosis of pneumonia complicating SBCT. METHODS: We conducted a prospective study of patients admitted to trauma intensive care unit for SBCT between January 2020 and February 2023. Patients were divided into two groups according to whether or not they developed pneumonia...
October 5, 2023: La Tunisie Médicale
https://read.qxmd.com/read/38465144/ift140-mutation-and-end-stage-renal-disease-in-mainzer-saldino-syndrome-a-case-report
#32
Sara E Marhoon, Ali H Ali, Ali Husain, Ali A Alsudan, Eman G Elshabrawy
Mainzer-Saldino syndrome (MSS) or conorenal syndrome (CRS) is a rare autosomal recessive ciliopathy characterized by multiorgan affection, typically presents with a triad of nephronophthisis (NPHP), retinitis pigmentosa (RP), and cone-shaped epiphysis (CSE) with varying degrees of severity. A 20-month-old male is experiencing recurrent pneumonia attacks, an elevated serum creatinine level, proteinuria, and high anion gap partially compensated metabolic acidosis were incidentally discovered during one of his hospitalizations...
February 2024: Curēus
https://read.qxmd.com/read/38464923/clinical-evolution-of-antisynthetase-syndrome-associated-interstitial-lung-disease-after-covid-19-in-a-man-with-klinefelter-syndrome-a-case-report
#33
Xiang-Xiang Wu, Jian Cui, Shi-Yao Wang, Tian-Tian Zhao, Ya-Fei Yuan, Long Yang, Wei Zuo, Wen-Jian Liao
BACKGROUND: This study presents a case of rapidly developing respiratory failure due to antisynthetase syndrome (AS) following coronavirus disease 2019 (COVID-19) in a 33-year-old man diagnosed with Klinefelter syndrome (KS). CASE SUMMARY: A 33-year-old man with a diagnosis of KS was admitted to the Department of Pulmonary and Critical Care Medicine of a tertiary hospital in China for fever and shortness of breath 2 wk after the onset of COVID-19. Computed tomography of both lungs revealed diffuse multiple patchy heightened shadows in both lungs, accompanied by signs of partial bronchial inflation...
February 26, 2024: World Journal of Clinical Cases
https://read.qxmd.com/read/38464350/deep-learning-automation-of-radiographic-patterns-for-hallux-valgus-diagnosis
#34
EDITORIAL
Angela Hussain, Cadence Lee, Eric Hu, Farid Amirouche
Artificial intelligence (AI) and deep learning are becoming increasingly powerful tools in diagnostic and radiographic medicine. Deep learning has already been utilized for automated detection of pneumonia from chest radiographs, diabetic retinopathy, breast cancer, skin carcinoma classification, and metastatic lymphadenopathy detection, with diagnostic reliability akin to medical experts. In the World Journal of Orthopedics article, the authors apply an automated and AI-assisted technique to determine the hallux valgus angle (HVA) for assessing HV foot deformity...
February 18, 2024: World Journal of Orthopedics
https://read.qxmd.com/read/38463407/acute-pyelonephritis-by-scrub-typhus-a-rare-condition
#35
Debashis Priyadarshan Sahoo, Soumya Ranjan Pradhan, Gwenette War, Annu Gupta, Ruth K Tara
Scrub typhus is prevalent in tropical countries and can have a varied spectrum of presentations from pneumonia, gastroenteritis, lymphadenitis, meningitis, encephalitis, and acute kidney injury to multi-organ dysfunction syndrome. Urinary tract infections like cystitis and pyelonephritis are rarely reported. Here we present an atypical presentation of a 53-year-old female with diabetes mellitus who came to the outpatient department with complaints of high-grade fever, burning micturition, and left flank pain for three days and was initially treated outpatient basis with oral antibiotics...
March 2024: Curēus
https://read.qxmd.com/read/38463387/case-report-pneumonia-caused-by-chlamydia-psittaci-and-cryptococcus-co-infection
#36
Anbing Zhang, Xiaoli Lao, Jinguang Liang, Xiuqiong Xia, Lei Ma, Jianping Liang
This study presents a rare case of pneumonia caused by a co-infection of Chlamydia psittaci and Cryptococcus , confirmed by metagenomic next-generation sequencing (mNGS). The patient, who had underlying chronic hepatitis B, had adopted a stray pigeon before the onset of the disease. The primary symptoms were fever, and a productive cough. The patient recovered following treatment with moxifloxacin and itraconazole. C. psittaci and Cryptococcus infections may both have been transmitted from the stray pigeon...
2024: Infection and Drug Resistance
https://read.qxmd.com/read/38462601/exosomal-circrnas-in-the-plasma-serve-as-novel-biomarkers-for-ipf-diagnosis-and-progression-prediction
#37
JOURNAL ARTICLE
Wenhua Gan, Wenwen Song, Yujuan Gao, Xuexue Zheng, Fengjuan Wang, Zirui Zhang, Ke Zen, Hongwei Liang, Xin Yan
BACKGROUND: Idiopathic Pulmonary Fibrosis (IPF) is a type of chronic interstitial pneumonia, often fatal, with elusive causes and a bleak prognosis. Its treatment options are limited and largely ineffective. Early detection and precise diagnosis are pivotal in managing the disease effectively and enhancing patient survival rates. Recently, the quest for trustworthy biomarkers for IPF has gained momentum. Notably, emerging studies indicate that circular RNAs (circRNAs) found in exosomes may hold significant potential as valuable diagnostic markers...
March 10, 2024: Journal of Translational Medicine
https://read.qxmd.com/read/38460615/zinc-deficiency-is-a-potential-risk-factor-for-covid-19-progression-to-pneumonia-requiring-oxygen-therapy
#38
JOURNAL ARTICLE
Koji Fujita, Kazuki Ocho, Tomoka Kadowaki, Takashi Yorifuji, Hideharu Hagiya, Fumio Otsuka
INTRODUCTION: Various risk factors for developing severe coronavirus disease 2019 (COVID-19) have been reported. However, studies on the nutritional-related risk factors are limited. In this study, we investigated the effects of serum zinc deficiency on the severity of COVID-19. METHODS: The study included a total of 60 COVID-19 patients who were admitted to Tsuyama Chuo Hospital between March 2020 and April 2021. We divided the patients into two categories based on serum levels of zinc (normal and latent zinc deficiency vs...
March 7, 2024: Journal of Infection and Chemotherapy: Official Journal of the Japan Society of Chemotherapy
https://read.qxmd.com/read/38460070/drug-gene-risk-stratification-in-patients-with-suspected-drug-induced-interstitial-lung-disease
#39
JOURNAL ARTICLE
Marjolein Drent, Petal A Wijnen, Naomi T Jessurun, Ankie M Harmsze, Otto Bekers, Aalt Bast
BACKGROUND: Pulmonary toxicity has been associated with drug use. This is often not recognized in clinical practice, and underestimated. OBJECTIVE: We aimed to establish whether polymorphisms in certain genes corresponding with a metabolic pathway of drug(s) used are associated with pulmonary toxicity in patients with suspected drug-induced interstitial lung disease (DI-ILD). METHODS: This retrospective observational study explored genetic variations in three clinically relevant cytochrome P450 (CYP) iso-enzymes (i...
March 9, 2024: Drug Safety: An International Journal of Medical Toxicology and Drug Experience
https://read.qxmd.com/read/38459147/neurosurgical-intervention-for-the-meckel-gruber-syndrome-a-systematic-review
#40
REVIEW
Jefferson Heber Marques Fontes Junior, Silvio Porto Junior, Hugo Nunes Pustilnik, Leonardo de Almeida Leão, Matheus Gomes da Silva da Paz, Taiane Brito Araujo, Fernanda Oliveira Gonçalves de Deus, Tancredo Alcântara, Jules Carlos Dourado, Leonardo Miranda de Avellar
INTRODUCTION: Meckel-Gruber Syndrome (MKS) is an autosomal recessive genetic disorder, notable for its triad of occipital encephalocele, polycystic renal dysplasia, and postaxial polydactyly. Identified by Johann Friederich Meckel in 1822, MKS is categorized as a ciliopathy due to gene mutations. Diagnosis is confirmed by the presence of at least two key features. The condition is incompatible with life, leading to death in the womb or shortly after birth. Recent studies have largely focused on the genetic aspects of MKS, with limited information regarding the impact of neurosurgical approaches, particularly in treating encephaloceles...
March 9, 2024: Child's Nervous System: ChNS: Official Journal of the International Society for Pediatric Neurosurgery
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