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https://www.readbyqxmd.com/read/28821087/in-vivo-antihyperlipidemic-and-antioxidant-activity-of-porphyran-in-hyperlipidemic-mice
#1
Xiaomei Wang, Weida Li, Li Xiao, Chundong Liu, Huimin Qi, Zhongshan Zhang
The hypolipidemic and antioxidant effects of porphyran from the red algae Porphyra haitanensis as a dietary supplement were evaluated in mice. The levels of serum TC, TG and LDL-C in MP group increased significantly (p<0.05 or p<0.01) by 28.5%, 29.4% and 33.5% compared with the model group. These significant rises were accompanied by significant declines of plasma HDL-C by 21.6% compared with the model group. In addition, the liver content of malondialdehyde significantly decreased, while the superoxide dismutase, catalase, glutathione peroxidase activities significantly increased...
October 15, 2017: Carbohydrate Polymers
https://www.readbyqxmd.com/read/28811778/effects-of-blood-lipid-stability-on-progression-of-carotid-atherosclerosis
#2
Yu Ding, Bo Li, Feng Tian, Shanshan Zhou, Yundai Chen
OBJECTIVE: To evaluate the effects of blood lipid stability on progression of carotid atherosclerosis. METHODS: A total of 416 patients who had physical examination in our hospital annually from January 2010 to December 2015 were selected and divided into a progression group (n=216) and a non-progression group (n=200) according to the intima-media thickness measured by carotid ultrasound. The levels of lipid-related parameters within five years were retrospectively analyzed to calculate the smoothness index (SI = x±/s)...
May 2017: Pakistan Journal of Medical Sciences Quarterly
https://www.readbyqxmd.com/read/28810550/2d-sti-combined-with-gated-99-tc-m-mibi-mpi-for-the-diagnosis-of-myocardial-ischemia-in-hypercholesterolemia-patients
#3
Yi Song, Rui-Fang Zhang, Yu Liu
This study aimed to investigate the reliability of ultrasound two-dimensional speckle tracking imaging (2D-STI) for the evaluation of myocardial ischemia in familial hypercholesterolemia (FH) patients. We recruited 28 patients clinically diagnosed with homozygous familial hypercholesterolemia (HoFH) and subjected them to 2D-STI, gated transthoracic Doppler echocardiography (TTDE), and (99)Tc(m)-methoxyisobutylisonitrile myocardial perfusion imaging ((99)Tc(m)-MIBI MPI). The sensitivity, specificity and diagnostic accordance rate of TTDE and 2D-STI for myocardial ischemia in HoFH patients were compared with the (99)Tc(m)-MIBI scores...
August 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28807325/radioguided-surgery-in-primary-hyperparathyroidism-results-and-correlation-with-intraoperative-histopathologic-diagnosis
#4
Juan P Suárez, María L Domínguez, Francisco J de Santos, José M González, Nuria Fernández, Fidel J Enciso
INTRODUCTION AND OBJECTIVES: Radioguided surgery is a minimally invasive surgical technique for the treatment of primary hyperparathyroidism. The goals of our study were to evaluate the rate of success and compare the results with intraoperative histological analysis. METHODS: We retrospectively studied 84 patients with primary parathyroidism who had undergone radioguided surgery. All the patients had a positive parathyroid scintigraphy prior to surgery. An intravenous injection of Tc-99m sestamibi was administered before surgery, and radioguided location of the pathologic parathyroid tissue was performed using an intraoperative gamma probe, applying the "20% rule"...
August 11, 2017: Acta Otorrinolaringológica Española
https://www.readbyqxmd.com/read/28796034/the-association-between-xpg-polymorphisms-and-cancer-susceptibility-evidence-from-observational-studies
#5
Cuihong Han, Xiaoyi Huang, Ruixi Hua, Shujie Song, Lihua Lyu, Na Ta, Jinhong Zhu, Peixi Zhang
BACKGROUND: Exposure to environmental carcinogens can cause damages to DNA. If not properly repaired, the DNA damages may increase the risk of carcinogenesis. Xeroderma pigmentosum group G (XPG) gene is an essential gene in the nucleotide excision repair (NER) pathway. The association between XPG polymorphisms and cancer susceptibility has been the focus of attention in the molecular epidemiology of cancer. However, the conclusions have been divergent. Therefore, we conducted a comprehensive meta-analysis to precisely evaluate the association of 3 frequently investigated XPG polymorphisms (rs751402, rs873601, and rs2296147) with cancer risk...
August 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28795384/contribution-of-hepatobiliary-scintigraphy-in-assessing-alpps-most-suited-timing
#6
Stéphanie Truant, Clio Baillet, Anne Claire Deshorgue, Mehdi El Amrani, Damien Huglo, François-René Pruvot
To reduce post-hepatectomy liver failure (PHLF), associating liver partition and portal vein ligation for staged hepatectomy (ALPPS) has been recently developed for patients with a limited future remnant liver (FRL). Nevertheless, high morbi-mortality rates have been reported . The current study aimed to analyze the kinetics of FRL function in patients who were offered ALPPS. Serial SPECT (99 m)Tc-mebrofenin hepatobiliary scintigraphy (HBS) was performed in all patients before and after surgery as well as at inter-stage to quantitatively assess hepatic function [total liver (TL) and FRL]...
August 9, 2017: Updates in Surgery
https://www.readbyqxmd.com/read/28794654/retrospective-study-to-identify-trigeminal-cervical-ocular-referred-pain-as-a-new-causative-entity-of-ocular-pain
#7
Scheffer Cg Tseng, Anny Ms Cheng, Yao Fu
PURPOSE: To determine the prevalence and clinical characteristics of trigeminal-cervical (TC) ocular referred pain. METHODS: A retrospective study of 1,680 patients seen during 2002-2010 was performed in an ocular surface specialty center to identify patients with or without TC pain defined as ocular pain with ipsilateral trigger points located at the occipital region. Patients with refractory TC pain despite topical anesthetics and conventional treatments received interventional injection to each trigger point...
2017: Journal of Pain Research
https://www.readbyqxmd.com/read/28766633/structure-and-reactivities-of-rhenium-and-technetium-bis-arene-sandwich-complexes-m-%C3%AE-6-arene-2
#8
Giuseppe Meola, Henrik Braband, Sara Jordi, Thomas Fox, Olivier Blacque, Bernhard Spingler, Roger Alberto
Sandwich complexes are important building blocks in medicinal inorganic chemistry for group 6 and 8 elements but are almost unknown for the manganese triad. We present the syntheses and full characterization of the mixed-arene (99)Tc sandwich complexes [(99)Tc(η(6)-hmbz)(η(6)-C6H5-NH3)](PF6)2 and [(99)Tc(η(6)-hmbz)(η(6)-C6H5-Br)](PF6). Both comprise functionalities for conjugation to targeting molecules or for being included as substructures in pharmaceutically active lead compounds. Since η(6)-benzene ligands are too stably bound to be replaced with incoming ligands, we prepared naphthalene complexes [Re(η(6)-C6H6)(η(6)-napht)](+) and [Re(η(6)-napht)2](+)...
August 2, 2017: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/28732535/case-report-rare-skeletal-manifestations-in-a-child-with-primary-hyperparathyroidism
#9
Maulee Hiromi Arambewela, Kamani Danushka Liyanarachchi, Noel P Somasundaram, Aruna S Pallewatte, Gamini L Punchihewa
BACKGROUND: Primary hyperparathyroidism (PHPT) is uncommon among children with an incidence of 1:300,000. This diagnosis is often missed in children in contrast to adults where it is detected at a pre symptomatic stage due to routine blood investigations. Etiology of PHPT can be due to adenoma, hyperplasia or rarely carcinoma. CASE PRESENTATION: A 12 year old Sri Lankan girl presented with progressive difficulty in walking since 1 year. On examination she had bilateral genu valgum...
July 21, 2017: BMC Endocrine Disorders
https://www.readbyqxmd.com/read/28702615/thiourea-derivatives-as-chelating-agents-for-bioconjugation-of-rhenium-and-technetium
#10
J D Castillo Gomez, A Hagenbach, U I M Gerling-Driessen, B Koksch, N Beindorff, W Brenner, U Abram
Potential tetradentate thiocarbamoylbenzamidine derivatives H4L have been synthesized from the corresponding benzimidoyl chlorides and triglycine. They are suitable chelating agents for the oxidotechnetium(v) and oxidorhenium(v) cores and form stable, neutral [MO(HL)] complexes with an equatorial SN3 coordination sphere and an additional, uncoordinated carboxylic group, which can be used for bioconjugation. Representatives of the rhenium and (99)Tc products have been isolated and analyzed with spectroscopic methods and X-ray diffraction...
July 12, 2017: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/28693441/ckd-epi-creatinine-cystatin-c-glomerular-filtration-rate-estimation-equation-seems-more-suitable-for-chinese-patients-with-chronic-kidney-disease-than-other-equations
#11
Xiao-Hua Chi, Gui-Ping Li, Quan-Shi Wang, Yong-Shuai Qi, Kai Huang, Qian Zhang, Yao-Ming Xue
BACKGROUND: The aim of this study was to identify the optimal equation that accurately estimates the glomerular filtration rate (GFR) and the chronic kidney disease (CKD) stage in the Chinese population. METHODS: A total of 1296 Chinese patients aged 18-65 years old were enrolled in this study. The estimated GFRs (eGFRs) calculated separately by three Diet in Renal Disease (MDRD) equations and three Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equations were compared with the reference GFR (rGFR) measured by the (99)Tc(m)-DTPA renal dynamic imaging method...
July 10, 2017: BMC Nephrology
https://www.readbyqxmd.com/read/28688340/pesticide-tailwater-deeply-treated-by-tubular-porous-electrode-reactor-tper-purpose-for-discharging-and-cost-saving
#12
Yonghao Zhang, Kajia Wei, Anlin Xu, Weiqing Han, Xiuyun Sun, Jiansheng Li, Jinyou Shen, Lianjun Wang
Pesticide tailwater often contains residual and toxic contaminants of triazole fungicides (TFs) due to their poor biodegradability which will do great harm to local aquatic systems. For this case, a novel electrochemical reactor (TPER) equipped a tubular porous RuO2-Sb2O5-SnO2 electrode was assembled and then employed to deeply treat pesticide tailwater. Characterizations of the electrode studied by SEM, EDS and XRD analysis indicated that it owns a porous structure and a compact and crack-free surface. Influence of the porous structure on electrochemical property was examined by cyclic voltammetry and normal pulse voltammetry...
October 2017: Chemosphere
https://www.readbyqxmd.com/read/28685716/gene-variations-of-sixth-complement-component-affecting-tacrolimus-metabolism-in-patients-with-liver-transplantation-for-hepatocellular-carcinoma
#13
Jian-Hua Liao, Chang-Can Li, Shao-Han Wu, Jun-Wei Fan, Hai-Tao Gu, Zhao-Wen Wang
BACKGROUND: Orthotopic liver transplantation (OLT) improves the prognosis of patients with hepatocellular carcinoma (HCC). Moreover, the complement system is a powerful immune effector that can affect liver function and process of liver cirrhosis. However, studies correlating the complement system with tacrolimus metabolism after OLT are scarce. In this study, the role of single nucleotide polymorphisms (SNPs) associated with the sixth complement component (C6) in tacrolimus metabolism was investigated during the early stages of liver transplantation...
July 20, 2017: Chinese Medical Journal
https://www.readbyqxmd.com/read/28683236/the-results-of-parathyroid-hormone-assay-in-parathyroid-aspirates-in-preoperative-localization-of-parathyroid-adenomas-for-focused-parathyroidectomy-in-patients-with-negative-or-suspicious-technet%C3%A4-um-99-msestam%C3%A4-b%C3%A4-scans
#14
Aysenur Ozderya, Sule Temizkan, Kenan Cetin, Sule Ozugur, Aylin Ege Gul, Kadriye Aydin
OBJECTIVE: This study aims to evaluate the results of parathyroid hormone (PTH) assay in parathyroid aspirates to determine uniglandular disease by an endocrinologist-performed ultrasound in patients with discordant or negative technetium ((99m)Tc) sestamibi scans and to evaluate whether this pocedure increases the number of focused parathyroidectomy (FP). METHODS: We analyzed the data of 65 patients who underwent an endocrinologist-performed ultrasound (US) guided parathyroid fine needle aspiration (FNA) with PTH wash-out, retrospectively...
July 6, 2017: Endocrine Practice
https://www.readbyqxmd.com/read/28668711/dhea-and-dhea-s-levels-in-posttraumatic-stress-disorder-a-meta-analytic-review
#15
REVIEW
Mirjam van Zuiden, Sanne Q Haverkort, Zhonglin Tan, Joost Daams, Anja Lok, Miranda Olff
Differences in hypothalamic-pituitary-adrenocortical (HPA) functioning between patients with posttraumatic stress disorder (PTSD) and controls are among the most consistent neurobiological findings in PTSD. HPA-axis activation results in the output of various steroid hormones including dehydroepiandrosterone (DHEA), which is then converted into dehydroepiandrosterone sulfate (DHEA-S), with anti-glucocorticoid actions among its pleiotropic effects. To investigate whether there is evidence for consistent differences in basal DHEA and DHEA-s levels between individuals with and without PTSD, we performed random-effect meta-analyses aggregating findings of previously published studies...
June 15, 2017: Psychoneuroendocrinology
https://www.readbyqxmd.com/read/28664482/prognostic-value-of-a-faster-low-radiation-myocardial-perfusion-spect-protocol-in-a-czt-camera
#16
Ronaldo S L Lima, Thaís R Peclat, Ana Carolina A H Souza, Aline M K Nakamoto, Felipe M Neves, Victor F Souza, Letícia B Glerian, Andrea De Lorenzo
To determine the prognostic value of a new, ultrafast, low dose myocardial perfusion SPECT (MPS) protocol in a cadmium-zinc telluride (CZT) camera. CZT cameras have introduced significant progress in MPS imaging, offering high-quality images despite lower doses and scan time. Yet, it is unknown if, with such protocol changes, the prognostic value of MPS is preserved. Patients had a 1-day 99 m-Tc-sestamibi protocol, starting with the rest (185-222 MBq) followed by stress (666-740 MBq). Acquisition times were 6 and 3 min, respectively...
June 29, 2017: International Journal of Cardiovascular Imaging
https://www.readbyqxmd.com/read/28658791/ectopic-parathyroid-adenoma-presenting-as-a-mediastinal-mass
#17
Aneesha Vaidya, Mangala Gouri, H M Sudha, Vijaya Mysorekar, Avinash Balekudura
A parathyroid adenoma present in an ectopic site, in the anterior mediastinum, is a rare cause of persistent hyperparathyroidism. Though its occurrence in the mediastinum is unusual, existence has been noted in literature for more than a century. We describe a case of a 35-year-old male presenting with complaints of pain abdomen, clinically diagnosed as acute necrotizing pancreatitis, with raised serum calcium. Patient received symptomatic treatment for the pancreatitis which subsided. However, high levels of serum calcium persisted...
May 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28645090/the-impact-of-tidal-and-mesoscale-eddy-advection-on-the-long-term-dispersion-of-99-tc-from-sellafield
#18
Magne Simonsen, Øyvind Saetra, Pål Erik Isachsen, Ole Christian Lind, Hilde Kristin Skjerdal, Brit Salbu, Hilde Elise Heldal, Justin P Gwynn
In the present work, numerical models are used to study the fate of the (99)Tc discharges from Sellafield with a specific focus on the role of mesoscale eddy and tidal advection on the transport and dispersion of this radionuclide. Transport estimates are made with an ocean model that resolves a large part of the ocean mesoscale eddy field and also includes tides. Equivalent estimates are also computed with another model in which these processes are either absent or parametrized. Comparison with field observations shows that the coarse-resolution model can reproduce the general features of the observed time-space (99)Tc distribution if the diffusivity in its eddy parametrization scheme is suitably chosen...
June 20, 2017: Journal of Environmental Radioactivity
https://www.readbyqxmd.com/read/28622639/an-investigation-into-the-rapid-removal-of-tetracycline-using-multilayered-graphene-phase-biochar-derived-from-waste-chicken-feather
#19
Huiqin Li, Jingtao Hu, Yue Meng, Jinhua Su, Xiaojing Wang
This study investigated the removal of tetracycline (TC) using multilayered graphene-phase biochar (MGB) derived from waste chicken feather. MGB was produced through a two-stage carbonization and KOH-activation method. MGB was characterized by scanning electron microscopy (SEM), transmission electron microscope (TEM), Fourier transform infrared (FT-IR), Raman spectra, Zeta potential and elemental analysis. Various chemical functional groups were demonstrated on the surface of MGB. MGB was featured by a very large BET surface area of 1838m(2)/g...
June 13, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28622166/quantitative-analysis-of-iodine-image-of-dual-energy-computed-tomography-at-rest-comparison-with-99mtc-tetrofosmin-stress-rest-single-photon-emission-computed-tomography-myocardial-perfusion-imaging-as-the-reference-standard
#20
Takehiro Nakahara, Takuji Toyama, Masahiro Jinzaki, Ryotaro Seki, Yuichiro Saito, Tetsuya Higuchi, Minoru Yamada, Masashi Arai, Yoshito Tsushima, Sachio Kuribayashi, Masahiko Kurabayashi
PURPOSE: Dual-energy computed tomography (DECT) can be used for visual determination of iodine distribution in the myocardium (iodine image); however, the accuracy and reproducibility of the process remains debatable. Because of the low contrast-to-noise ratio of CT, we hypothesized that quantitative measurement may be more accurate for detecting myocardial ischemia. In this study, we evaluated our quantitative method by comparing it with visual analysis using Tc-tetrofosmin (TF) stress-rest single-photon emission computed tomography (SPECT) myocardial perfusion imaging (MPI) as the reference standard...
June 15, 2017: Journal of Thoracic Imaging
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