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Tc 99

Shirmir D Branch, Amanda D French, Amanda M Lines, Brian M Rapko, William R Heineman, Samuel A Bryan
A protocol is presented that allows for the quantitative conversion and subsequent in situ spectroscopic analysis of [Re(CO)3]+ species in simulated Hanford tank waste. In this test case, the non-radioactive metal rhenium, is substituted for technetium (Tc-99), a weak beta emitter, to demonstrate proof of concept for a method to measure a non-pertechnetate form of technetium in Hanford tank waste. The protocol encompasses adding a simulated waste sample containing the non-emissive [Re(CO)3]+ species to a developer solution that enables the rapid, quantitative conversion of the non-emissive species to a luminescent species which can then be detected spectroscopically...
December 14, 2017: Environmental Science & Technology
Mehravar Rafati, Hemmatollah Rouhani, Ahmad Bitarafan-Rajabi, Mahsa Noori-Asl, Bagher Farhood, Hadi Taleshi Ahangari
BACKGROUND: Compton-scattered photons transfer incorrect spatial information. These photons are detected in used photo-peak energy window. In this study, three scatter correction procedures including dual-energy window (DEW), three energy window (TEW), and new approach were evaluated, and then the best procedure based on simulation and clinical conditions introduced. MATERIALS AND METHODS: In this study, simulation projections and three-dimensional nonuniform rational B-spline-based Cardiac-Torso phantoms were produced by GEANT4 application for emission tomography simulation code...
October 2017: Journal of Cancer Research and Therapeutics
Tao Jiang, Guoliang Qiao, Xiao Zheng, Zhen Wen, Dongxue Zhang
The relationship between Type 2 Diabetes Mellitus(T2DM) and cancer risk has been investigated for more than a decade. Many types of cancer were confirmed to be related with T2DM. The aim of this study is to identify the relationship between T2DM and the prevalence and long-term survivals of Thyroid Carcinoma(TC) using propensity score matching. In present study, 1658 thyroid nodule patients who were diagnosis in Beijing Shijitan hospital were divided into two groups: the TC group (N = 455, 27.4%), and the benign thyroid nodule(BTN) group (N = 1203, 73...
November 14, 2017: Oncotarget
Georgia Keramida, Emma Wroe, Nicola Winterman, Mark Aplin, A Michael Peters
Background Following convection from blood capillaries, plasma proteins are transported to loco-regional lymph nodes in two stages: first, uptake into peripheral lymphatics, and second, transport to nodes. Purpose To introduce a new parameter of lymphatic function that quantifies stage 2 - lymphatic drainage efficiency (LDE). Material and Methods Percentage injected activity (IIQ) in ilio-inguinal nodes 150 min following subcutaneous foot web-space injection of Tc-99 m-nanocolloid was measured in 102 patients undergoing lymphoscintigraphy using a method in which a standard is placed by image guidance over the nodes...
January 1, 2017: Acta Radiologica
Hongna Li, Binxu Li, Zhiguo Zhang, Changxiong Zhu, Yunlong Tian, Jing Ye
The evolution of microbial communities during the electrokinetic treatment of antibiotic-polluted soil (EKA) was investigated with chlortetracycline (CTC), oxytetracycline (OTC) and tetracycline (TC) as template antibiotics. The total population of soil microorganisms was less affected during the electrokinetic process, while living anti-CTC, anti-OTC, anti-TC and anti-MIX bacteria were inactivated by 10.48%, 31.37%, 34.76%, and 22.08%, respectively, during the 7-day treatment compared with antibiotic-polluted soil without an electric field (NOE)...
November 30, 2017: Ecotoxicology and Environmental Safety
Karen Axten, Kerri Hawkins, David J Tybor, Josh Bernoff, Wayne Altman
BACKGROUND: Increasing weight-related illness in the United States has led to 120,000 preventable deaths annually and soaring medical costs. Treating patients in a group setting may be more effective than traditional care (TC) in achieving behavioral change. We studied a wellness-group (WG) model to determine whether it could generate sustained behavioral change and weight loss in a subset of patients. METHODS: 99 patients with a body mass index (BMI) >30 kg/m2 from 1 family practice volunteered to participate in a 15-visit WG co-led by a family physician and dietitian...
November 2017: Journal of the American Board of Family Medicine: JABFM
Mike Sathekge, Osvaldo Garcia-Perez, Diana Paez, Noura El-Haj, Taylor Kain-Godoy, Ismaheel Lawal, Enrique Estrada-Lobato
OBJECTIVE: To determine the added value of CT over planar and SPECT-only imaging in the diagnosis of musculoskeletal infection using (99m)Tc-UBI 29-4. MATERIALS AND METHODS: 184 patients with suspected musculoskeletal infection who underwent planar and SPECT/CT imaging with (99m)Tc-UBI 29-41 were included. Planar, SPECT-only and SPECT/CT images were reviewed by two independent analysts for presence of bone or soft tissue infection. Final diagnosis was confirmed with tissue cultures, surgery/histology or clinical follow-up...
November 21, 2017: Annals of Nuclear Medicine
Rapat Pittayanon, Rungsun Rerknimitr, Alan Barkun
BACKGROUND AND AIM: Endoscopic hemostatic techniques remain poorly effective for GI tumor bleeding. We assessed Tc-325 (Hemospray) for this indication and determined possible predictors of decreased recurrent bleeding and improved 6-month survival in affected patients. METHODS: This retrospective study identified 99 patients with active malignant GI bleeding (primary or metastatic) treated with Tc-325. Eleven patients were excluded because of incomplete data. Data on patient characteristics and possible predictive factors of early (72-hour) and delayed (7, 14 and 30-day) recurrent bleeding, as well as six-month survival, were collected...
November 17, 2017: Gastrointestinal Endoscopy
Reza Daryabeygi-Khotbehsara, Mahdieh Golzarand, Mohammad Payam Ghaffari, Kurosh Djafarian
BACKGROUND & OBJECTIVE(S): Global prevalence of type 2 diabetes (T2D) is very high and is currently growing alarmingly. With respect to recent researchers' attention to the potential role of herbal medicine in disease prevention and management, the present meta-analysis review investigates the effectiveness of Nigella sativa (N. sativa), a popular herb, in T2D. METHODS: Literature search was conducted covering PubMed/Medline, Scopus, and Cochrane Registry of Clinical Trials up to February 2017 to obtain the relevant published intervention studies...
December 2017: Complementary Therapies in Medicine
Rakhee Vatsa, Jaya Shukla, Bhagwant Rai Mittal, Apurva Sood, Raman Kumar Joshi, Kanchan Palarwal, Priya Bhusari, Manish Modi
Purpose of Study: Loss of dopamine neurons in the brain is a characteristic feature of Parkinson's disease (PD). TRODAT-1 is a tropane derivative that binds to dopamine transporter (DAT) receptors. It can be used for noninvasive in vivo imaging of DAT receptors leading to the early detection of PD. The present study aims to optimize the in-house radiolabeling of TRODAT-1 with Tc-99 m in hospital radiopharmacy set up along with performing single-photon emission computed tomography/computed tomography imaging in patients with PD...
October 2017: Indian Journal of Nuclear Medicine: IJNM: the Official Journal of the Society of Nuclear Medicine, India
Valerii P Tarasov, Gayana А Kirakosyan, Konstantin E German
(99) Tc NMR has been suggested as an original method of evaluating the content of oxygen isotopes in oxygen-18 enriched water, a precursor for the production of radioisotope fluorine-18 used in positron emission tomography. To this end, solutions of NH4 TcO4 or NaTcO4 (up to 0.28 mol/L) with natural abundance of oxygen isotopes in virgin or recycled (18) O-enriched water have been studied by (99) Tc NMR. The method is based on (16) O/(17) O/(18) O intrinsic isotope effects in the (99) Tc NMR chemical shifts and the statistical distribution of oxygen isotopes in the coordination sphere of TcO4(-) and makes it possible to quantify the composition of enriched water by measuring the relative intensities of the (99) Tc NMR signals of the Tc(16) O4 - n(18) On(-) isotopologues...
November 11, 2017: Magnetic Resonance in Chemistry: MRC
Jason M Etchegaray, Madelene J Ottosen, Theresa Dancsak, Eric J Thomas
OBJECTIVES: We sought to examine the association between willingness of health-care professionals to speak up about patient safety concerns and their perceptions of two types of organizational culture (ie, safety and teamwork) and understand whether nursing professionals and other health-care professionals reported the same barriers to speaking up about patient safety concerns. METHODS: As part of an annual safety culture survey in a large health-care system, we asked health-care professionals to tell us about the main barriers that prevent them from speaking up about patient safety concerns...
November 4, 2017: Journal of Patient Safety
Zbigniew Tymiński, Paweł Saganowski, Ewa Kołakowska, Anna Listkowska, Tomasz Ziemek, Daniel Cacko, Tomasz Dziel
The gamma emitting impurities in (99m)Tc solution obtained from enriched molybdenum (100)Mo metallic target after its irradiation in a cyclotron were measured using a high-purity germanium (HPGe) detector. The radioactivity range of tested samples of (99m)Tc was rather low, in the range from 0.34 to 2.39 MBq, thus creating a challenge to investigate the standard measurement HPGe system for impurity detection and quantification. In the process of (99m)Tc separation from irradiated target the AnaLig® Tc-02 resin, Dionex H(+) and Alumina A columns were used...
October 12, 2017: Applied Radiation and Isotopes
Phillip E Warwick, Ian W Croudace
This paper describes an early-stage evaluation of a purpose-designed extraction/detection system that can be deployed by non-specialists either on-site or as part of a mobile laboratory. The system comprises three main components; (1) an optimised compact extraction system for recovery of radionuclides from the waste form; (2) an extraction test strip designed to recover the radionuclides from the waste digest; (3) a scintillation-based detection system capable of quantification of alpha, low energy beta and high energy beta emitting radionuclides...
2017: Journal of Radioanalytical and Nuclear Chemistry
Pawel Gaca, Phillip E Warwick, Ian W Croudace
Liquid scintillation spectrometry is widely used for the analysis of alpha and beta emitting radionuclides. Robust calibration of liquid scintillation (LS) spectrometers is fundamental to accurate LS measurement but at the same time is time consuming and costly, particularly if a wide range of radionuclides are analysed by the laboratory. The frequency of the calibration varies in different laboratories and is based on many practical and operational factors. This work summarizes the observations regarding variations in 1220 Quantulus spectrometers efficiency calibrations performed annually using various radionuclides: (3)H (63)Ni, (55)Fe, (36)Cl, (45)Ca, (147)Pm, (241)Pu, (99)Tc for a period of 9 years and discusses the implication to calibration frequency...
2017: Journal of Radioanalytical and Nuclear Chemistry
Dapeng Wu, Guodong Zhu, Jin Zeng, Wenbin Song, Ke Wang, Xinyang Wang, Peng Guo, Dalin He
Renal cell carcinoma (RCC) is a common malignant tumor of the urinary system, the pathogenesis of RCC is still unclear. It is reported that genetic variations in telomere length related-genes TERT and TERC are involved in the many types of cancers. However, little is known about the association between TERT and TERC polymorphisms and susceptibility to RCC risk. To solve this problem, a total of 293 patients with primary renal cell carcinoma and 459 healthy people were recruited in our study. Six SNPs of TERC and TERT were genotyped, and association analysis was performed...
September 29, 2017: Oncotarget
Chengliang Xiao, Mark A Silver, Shuao Wang
In this Frontier article, we pursue the sequestration of radionuclides from aqueous solution by using recently emerging metal-organic framework (MOF) materials. The design of MOF materials and their corresponding sorption properties towards radionuclides ((137)Cs, (90)Sr, (238)U, (79)Se, and (99)Tc) as well as their interaction mechanisms are highlighted. The present challenges and future prospects of removing radionulides with MOFs as sorbents are also demonstrated.
November 3, 2017: Dalton Transactions: An International Journal of Inorganic Chemistry
Namrata S Patil, Luisella Righi, Hartmut Koeppen, Wei Zou, Stefania Izzo, Federica Grosso, Roberta Libener, Marco Loiacono, Valentina Monica, Consuelo Buttigliero, Silvia Novello, Priti S Hegde, Mauro Papotti, Marcin Kowanetz, Giorgio V Scagliotti
INTRODUCTION: Malignant pleural mesothelioma (MPM) is a rare, highly aggressive, relatively chemo- and radio-resistant malignancy with limited therapeutic options. Our objective was to investigate the prevalence of PD-L1 and the characteristics of immune environment in this disease. METHODS: A total of 99 archival tumors from advanced stage MPM were immunohistochemically tested in parallel for PD-L1 in two different laboratories; and 87 of these were profiled for immune gene expression profiling by NanoString analysis for 800 genes...
October 24, 2017: Journal of Thoracic Oncology
Rasoul Abdollahzadeh, Parisa Moradi Pordanjani, Farideh Rahmani, Fatemeh Mashayekhi, Asaad Azarnezhad, Yaser Mansoori
PURPOSE: The purpose of this study was to evaluate the association of VDR Apa-I, Bsm-I, Fok-I, Taq-I single nucleotide polymorphisms (SNPs) with multiple sclerosis (MS) risk in an Iranian Kurdish population. MATERIALS AND METHODS: A population including of 118 patients and 124 healthy matched controls were recruited to the study. Genotyping of the SNPs was accomplished using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). RESULTS: The frequency of allele T of Fok-I (P = 0...
November 16, 2017: International Journal of Neuroscience
Satoshi Chiba, Toshio Wakabayashi, Yoshiaki Tachi, Naoyuki Takaki, Atsunori Terashima, Shin Okumura, Tadashi Yoshida
Transmutation of long-lived fission products (LLFPs: (79)Se, (93)Zr, (99)Tc, (107)Pd, (129)I, and (135)Cs) into short-lived or non-radioactive nuclides by fast neutron spectrum reactors without isotope separation has been proposed as a solution to the problem of radioactive wastes disposal. Despite investigation of many methods, such transmutation remains technologically difficult. To establish an effective and efficient transmutation system, we propose a novel neutron moderator material, yttrium deuteride (YD2), to soften the neutron spectrum leaking from the reactor core...
October 24, 2017: Scientific Reports
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