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https://www.readbyqxmd.com/read/28319500/clinical-response-profile-of-metastatic-advanced-pulmonary-neuroendocrine-tumors-to-peptide-receptor-radionuclide-therapy-with-177lu-dotatate
#1
Rahul V Parghane, Sanjay Talole, Kumar Prabhash, Sandip Basu
OBJECTIVES: The aims of this study were to perform multiparametric response assessment of metastatic/advanced pulmonary neuroendocrine tumors (NETs) to Lu-DOTATATE peptide receptor radionuclide therapy (PRRT) (clinical, biochemical, molecular/structural imaging, and survival assessment) and to study the relationship between response, mortality, and overall survival with dual-tracer molecular imaging parameters. METHODS: Twenty-two patients (6 women, 16 men; median age, 44 years; range, 16-72 years) of histopathologically proven pulmonary NETs with metastatic/advanced disease were included and analyzed retrospectively...
March 17, 2017: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/28292275/a-preliminary-investigation-on-single-nucleotide-polymorphism-rs2287622-of-bile-salt-export-pump-gene-in-patients-with-chronic-hepatitis-c-virus-infection-in-hunan-china
#2
Jian-Hua Lei, Xu Yang, Xin-Qiang Xiao, Zi Chen, Feng Peng
BACKGROUND: European researchers have underscored associations between single nucleotide polymorphism (SNP) rs2287622 of the hepatobiliary bile salt export pump (BSEP) gene and the risk of hepatitis C virus (HCV) infection. The distributions of SNP rs2287622 are racially specific. This study was aimed to preliminarily investigate the distribution of BSEP gene SNP rs2287622 in the Han patients with chronic HCV-infection (CHC) in Hunan, China. METHODS: BSEP gene SNP rs2287622 of 165 CHC patients, 99 patients with chronic hepatitis B virus infection (CHB) and 99 healthy individuals were analyzed by polymerase chain reaction-restriction fragment length polymorphism analysis and nucleotide sequencing...
March 14, 2017: BMC Gastroenterology
https://www.readbyqxmd.com/read/28280976/indicators-of-lung-shunt-fraction-determined-by-technetium-99%C3%A2-m-macroaggregated-albumin-in-patients-with-hepatocellular-carcinoma
#3
Joseph Ralph Kallini, Ahmed Gabr, Ryan Hickey, Laura Kulik, Kush Desai, Yihe Yang, Vanessa L Gates, Ahsun Riaz, Riad Salem, Robert J Lewandowski
PURPOSE: To determine the correlation of pre-procedural and imaging characteristics with lung shunt fraction (LSF) measured by technetium-99 m macroaggregated albumin ((99m)Tc-MAA) scan in patients with hepatocellular carcinoma. METHODS: A retrospective study was conducted of 428 subjects with hepatocellular carcinoma from 2004 to 2011 assessed for lung shunting by (99m)Tc-MAA scan. Baseline characteristics included age, gender, ethnicity, tumor burden, maximum dimension, number of lesions, presence of extrahepatic metastases, macrovascular (hepatic and portal vein) invasion, ascites on imaging, laboratory values, and alpha-fetoprotein (AFP)...
March 9, 2017: Cardiovascular and Interventional Radiology
https://www.readbyqxmd.com/read/28273234/non-hdl-cholesterol-is-a-good-predictor-of-the-risk-of-increased-arterial-stiffness-in-postmenopausal-women-in-an-urban-brazilian-population
#4
Rafael de Oliveira Alvim, Carlos Alberto Mourao-Junior, Géssica Lopes Magalhães, Camila Maciel de Oliveira, José Eduardo Krieger, José Geraldo Mill, Alexandre Costa Pereira
OBJECTIVES: Increased arterial stiffness is an important determinant of the risk of cardiovascular disease. Lipid profile impairment, especially hypercholesterolemia, is associated with stiffer blood vessels. Thus, the aim of this study was to determine which of the five circulating lipid components (high-density lipoprotein cholesterol (HDL-C), non-high-density lipoprotein cholesterol (non-HDL-C), low-density lipoprotein cholesterol (LDL), total cholesterol (TC) and triglycerides) is the best predictor of increased arterial stiffness in an urban Brazilian population...
February 1, 2017: Clinics
https://www.readbyqxmd.com/read/28256606/strain-tuned-enhancement-of-ferromagnetic-tc-to-176%C3%A2-k-in-sm-doped-bimno3-thin-films-and-determination-of-magnetic-phase-diagram
#5
Eun-Mi Choi, Josée E Kleibeuker, Judith L MacManus-Driscoll
BiMnO3 is a promising multiferroic material but it's ferromagnetic TC is well below room temperature and the magnetic phase diagram is unknown. In this work, the relationship between magnetic transition temperature (TC) and the substrate induced (pseudo-) tetragonal distortion (ratio of out-of-plane to in-plane lattice parameters, c/a) in BiMnO3 thin films, lightly doped to optimize lattice dimensions, was determined. For c/a > 0.99, hidden antiferromagnetism was revealed and the magnetisation versus temperature curves showed a tail behaviour, whereas for c/a < 0...
March 3, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28256403/the-utility-of-99m-tc-dpd-scintigraphy-in-the-diagnosis-of-cardiac-amyloidosis-an-australian-experience
#6
Peter T Moore, Matthew K Burrage, Emily Mackenzie, W Philip Law, Dariusz Korczyk, Peter Mollee
BACKGROUND: The uptake of bone-seeking radiotracers in the amyloid heart is well recognised. 99(m)Tc-DPD has been shown to be highly sensitive for cardiac transthyretin (ATTR) amyloid in an overseas population, but is not registered for use in Australia. We explored its utility as a diagnostic tool within our population. METHODS: Patients diagnosed with AL and ATTR (wild-type and inherited) cardiac amyloidosis were prospectively recruited from the Princess Alexandra Hospital Amyloidosis Centre...
February 16, 2017: Heart, Lung & Circulation
https://www.readbyqxmd.com/read/28248864/association-of-total-cholesterol-and-hdl-c-levels-and-outcome-in-coronary-heart-disease-patients-with-heart-failure
#7
Qin Zhao, Jianfei Li, Jin Yang, Rongshan Li
The aim of the study was to evaluate associations of total cholesterol (TC) and high density lipoprotein cholesterol (HDL-C) levels with prognosis in coronary heart disease (CHD) patients with heart failure (HF).Patients who were angiographical-diagnosis of CHD and echocardiographical-diagnosis of left ventricular ejection fraction (LVEF) < 45% were enrolled. Baseline characteristics were collected and association of TC and HDL-C levels with rehospitalization for HF and all-cause mortality was assessed...
March 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28242981/hepatitis-c-virus-related-arthritis-bone-scintigraphic-appearances
#8
Gul Ege Aktas, Ali Sarikaya, Ozan Kandemir
A symptomatic joint involvement and arthralgia are frequent in patients with chronic hepatitis C virus (HCV) infection. However, HCV infection-related arthritis (HCVrA) affects up to 4-11% of the subjects suffering from disease. We reported a patient with HCVrA presented with the commonly accepted diagnostic clinical signs and laboratory parameters. The painful joints distinctly demonstrated increased uptake of Tc-99 m methylene diphosphonate in scintigraphy and normal findings in radiography.
January 2017: Indian Journal of Nuclear Medicine: IJNM: the Official Journal of the Society of Nuclear Medicine, India
https://www.readbyqxmd.com/read/28238581/correlation-of-technetium-99m-macroaggregated-albumin-and-yttrium-90-glass-microsphere-biodistribution-in-hepatocellular-carcinoma-a-retrospective-review-of-pretreatment-single-photon-emission-ct-and-posttreatment-positron-emission-tomography-ct
#9
Paul Haste, Mark Tann, Scott Persohn, Thomas LaRoche, Vasantha Aaron, Thibault Mauxion, Nikhil Chauhan, Matthew R Dreher, Matthew S Johnson
PURPOSE: To evaluate whether technetium-99 ((99m)Tc)-labeled macroaggregated albumin (MAA) can predict subsequent yttrium-90 ((90)Y) distribution and imaging response in patients with hepatocellular carcinoma (HCC). MATERIALS: Retrospective review was performed of records of 83 patients with HCC who underwent (90)Y glass microsphere radioembolization with (99m)Tc-MAA single photon emission computed tomography (SPECT) and (90)Y positron emission tomography (PET)/CT between January 2013 and December 2014...
February 23, 2017: Journal of Vascular and Interventional Radiology: JVIR
https://www.readbyqxmd.com/read/28229896/-99-m-tc-mebrofenin-hepatobiliary-scintigraphy-in-a-patient-with-a-bilio-pleural-bronchial-fistula
#10
V Marín-Oyaga, K Cohen-Castillo, C Gutierrez-Villamil, S Arevalo-Leal
No abstract text is available yet for this article.
February 17, 2017: Revista Española de Medicina Nuclear e Imagen Molecular
https://www.readbyqxmd.com/read/28221786/chemical-trends-in-solid-alkali-pertechnetates
#11
Jamie Weaver, Chuck Z Soderquist, Nancy M Washton, Andrew S Lipton, Paul L Gassman, Wayne W Lukens, Albert A Kruger, Nathalie A Wall, John S McCloy
Insight into the solid-state chemistry of pure technetium-99 ((99)Tc) oxides is required in the development of a robust immobilization and disposal system for nuclear waste stemming from the radiopharmaceutical industry, from the production of nuclear weapons, and from spent nuclear fuel. However, because of its radiotoxicity and the subsequent requirement of special facilities and handling procedures for research, only a few studies have been completed, many of which are over 20 years old. In this study, we report the synthesis of pure alkali pertechnetates (sodium, potassium, rubidium, and cesium) and analysis of these compounds by Raman spectroscopy, X-ray absorption spectroscopy (XANES and EXAFS), solid-state nuclear magnetic resonance (static and magic angle spinning), and neutron diffraction...
February 21, 2017: Inorganic Chemistry
https://www.readbyqxmd.com/read/28219209/-value-of-99-tc-m-mdp-spect-ct-in-clinical-decision-making-for-nasopharyngeal-carcinoma-and-a-comparison-of-the-values-of-different-imaging-techniques-for-diagnosing-skull-base-bone-invasion
#12
W Li, R S Zhang, L Q Zhang, B G Lu, W H Fu
Objective: To analyze the clinical value of SPECT/CT in diagnosis of skull base bone invasion and clinical decision-making for nasopharyngeal carcinoma (NPC), and to compare their diagnostic value with SPECT/CT, CT, MRI, and MRI combined with SPECT (MRI-SPECT) for skull base bone invasion. Methods: Before treatment, among 348 newly diagnosed NPC patients, CT scan was performed in 186 patients (group A) and the remaining 162 patients received MRI scan (group B). Clinical doctors then made clinical management decisions according to the CT or MRI results...
February 23, 2017: Zhonghua Zhong Liu za Zhi [Chinese Journal of Oncology]
https://www.readbyqxmd.com/read/28216520/examination-of-some-factors-affected-right-to-left-shunt-rate-and-the-normal-value-of-right-to-left-shunt-rate-in-lung-perfusion-scintigraphy
#13
Fumitoshi Nakamura, Masafumi Okabe, Takaaki Ono, Yousuke Sugimura, Naoko Muromoto, Ryou Suzuki, Taketoshi Okawada
PURPOSE: Diagnosis for right-to-left shunt was determined by the assessment of shunt-rate, which was obtained by using (99 m)Tc-macroaggregated albumin. However, it is difficult to diagnose right-to-left shunt, using the normal level of shunt-rate measured by using conventional methods. To solve this problem, we investigated ourselves the normal level of shunt-rate. METHOD: We researched 20 patients with pulmonary embolism, and they didn't have right-to-left shunt...
2017: Nihon Hoshasen Gijutsu Gakkai Zasshi
https://www.readbyqxmd.com/read/28212051/-99m-tc-mag3-image-wisely
#14
Andrew T Taylor, Russell D Folks, A K M Fazlur Rahman, Aruna Polsani, Eva V Dubovsky, Raghuveer Halkar, Amita Manatunga
Purpose To determine if commonly administered doses of technetium 99m ((99m)Tc) mertiatide (MAG3) in the range of 300-370 MBq (approximately 8-10 mCi) contribute to image interpretation and justify the resulting radiation exposure. Materials and Methods The respective institutional review boards approved this HIPAA-compliant study and waived informed consent. Baseline and furosemide (99m)Tc-MAG3 imaging examinations in 50 patients suspected of having renal obstruction and 48 patients suspected of having renovascular hypertension (RVH) were randomly selected from archived databases and were independently scored by three experienced readers without access to 2-second flow images...
February 17, 2017: Radiology
https://www.readbyqxmd.com/read/28188015/sensitivity-and-negative-predictive-value-for-sentinel-lymph-node-biopsy-in-women-with-early-stage-cervical-cancer
#15
Gloria Salvo, Pedro T Ramirez, Charles F Levenback, Mark F Munsell, Elizabeth D Euscher, Pamela T Soliman, Michael Frumovitz
OBJECTIVE: The role of sentinel lymph node (SLN) biopsy alone for staging of early-stage cervical cancer remains controversial. We aimed to determine the validity of this technique in women with early-stage cervical cancer. METHODS: We retrospectively reviewed women with early-stage cervical cancer who underwent SLN mapping followed by complete pelvic lymphadenectomy as part of initial surgical management from August 1997 through October 2015. All modes of surgical approach were included...
April 2017: Gynecologic Oncology
https://www.readbyqxmd.com/read/28187392/reductive-immobilization-of-pertechnetate-in-soil-and-groundwater-using-synthetic-pyrite-nanoparticles
#16
Lijuan Huo, Wenbo Xie, Tianwei Qian, Xiaohong Guan, Dongye Zhao
Radioactive technetium ((99)Tc) is of intense concern because of its toxicity and high mobility in the environment. Reduction of Tc(VII) to Tc(IV) decreases the mobility and availability of technetium in soil and groundwater. In this study, pyrite nanoparticles (FeS2) were synthesized, characterized and tested for immobilizing/removing (99)Tc(VII) in soil and groundwater through batch and column experiments. Influences of particle dosage, dissolved organic matter (DOM), and pH on the reductive immobilization kinetics were examined...
May 2017: Chemosphere
https://www.readbyqxmd.com/read/28181084/vermicompost-as-a-natural-adsorbent-evaluation-of-simultaneous-metals-pb-cd-and-tetracycline-adsorption-by-sewage-sludge-derived-vermicompost
#17
Xin He, Yaxin Zhang, Maocai Shen, Ye Tian, Kaixuan Zheng, Guangming Zeng
The simultaneous adsorption of heavy metals (Pb, Cd) and organic pollutant (tetracycline (TC)) by a sewage sludge-derived vermicompost was investigated. The maximal adsorption capacity for Pb, Cd, and TC in a single adsorptive system calculated from Langmuir equation was 12.80, 85.20, and 42.94 mg L(-1), while for mixed substances, the adsorption amount was 2.99, 13.46, and 20.89 mg L(-1), respectively. The adsorption kinetics fitted well to the pseudo-second-order model, implying chemical interaction between adsorbates and functional groups, such as -COOH, -OH, -NH, and -CO, as well as the formation of organo-metal complexes...
February 8, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28181032/comprehensive-evaluation-of-chemiluminescent-immunoassays-for-the-laboratory-diagnosis-of-clostridium-difficile-infection
#18
A Makristathis, I Zeller, D Mitteregger, M Kundi, A M Hirschl
For the microbiological diagnosis of a Clostridium (C.) difficile infection (CDI), a two-test algorithm consisting of a C. difficile glutamate dehydrogenase (GDH)-immunoassay followed by a toxin-immunoassay in positive cases is widely used. In this study, two chemiluminescent immunoassays (CLIAs), one for GDH and the other for the toxins A and B, have been evaluated systematically using appropriate reference methods. Three-hundred diarrhoeal stool specimens submitted for CDI diagnosis were analysed by the LIAISON CLIAs (DiaSorin)...
February 8, 2017: European Journal of Clinical Microbiology & Infectious Diseases
https://www.readbyqxmd.com/read/28171870/methylene-tetrahydrofolate-reductase-mthfr-rs868014-polymorphism-regulated-by-mir-1203-associates-with-risk-and-short-term-outcome-of-ischemic-stroke
#19
Wei He, Minzhi Lu, Guoqing Li, Zhigang Sun, Dinghua Liu, Lujun Gu
BACKGROUND/AIMS: Genetic polymorphisms of methylene tetrahydrofolate reductase (MTHFR) were associated with ischemic stroke risk. This study analyzed MTHFR polymorphisms at the 3'-untranslated region for association with risk and outcome of ischemic stroke in a Chinese Han population. METHODS: 500 patients and 600 healthy volunteers were enrolled for MTHFR rs868014 genotyping identified bioinformatically. The binding of miR-1203 to MTHFR rs868014 was determined by luciferase assay, MTHFR expression was assessed using qRT-PCR, and plasma homocysteine levels were assayed by ELISA...
February 8, 2017: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/28159228/isobaric-dilution-analysis-as-a-calibration-tool-for-long-lived-radionuclides-in-icp-ms
#20
David Clases, Marvin Birka, Michael Sperling, Andreas Faust, Uwe Karst
A novel quantification method named isobaric dilution analysis (IBDA) is introduced for internal calibration using inductively coupled plasma mass spectrometry (ICP-MS). Unlike isotope dilution analysis (IDA), where a sample to be analysed for a target analyte element is spiked with an isotopically enriched solution of the same element, IBDA uses the fact that conventional mass analysers cannot distinguish between two isobaric isotopes of different elements. Therefore, in IBDA, the sample with the element of interest is spiked with a solution of a different element, which shares at least one isobaric isotope and shows similar chemical properties resulting in a similar response...
March 2017: Journal of Trace Elements in Medicine and Biology
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