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https://www.readbyqxmd.com/read/27908622/biomonitoring-of-persistent-organic-pollutants-pops-in-child-populations-living-near-contaminated-sites-in-mexico
#1
R Flores-Ramírez, F J Pérez-Vázquez, M Rodríguez-Aguilar, S E Medellín-Garibay, E Van Brussel, A C Cubillas-Tejeda, L Carrizales-Yáñez, F Díaz-Barriga
The aim of this study was to conduct a POP biomonitoring programme for children in high-risk areas. We evaluated 247 serum samples from children between the ages of 6 and 12years old from two zones in Mexico: (1) indigenous zones, which included Cuatlamayan (CUA), Tocoy (TOC), and Santa Maria Picula (SAM); and (2) industrial zones, which included Tercera Chica (TC), Industrial San Luis (IND) and Rincon de San Jose (SJR); Mundo Nuevo (MN); and Alpuyeca (ALP). Our results showed that α-endosulfan was similar to CUA, TOC, SAM, TC and MN (178...
November 28, 2016: Science of the Total Environment
https://www.readbyqxmd.com/read/27895949/primary-ewing-s-sarcoma-of-the-spine-in-a-two-year-old-boy
#2
Ali J Electricwala, Jaffer T Electricwala
Ewing's Sarcoma (ES) is a highly malignant bone tumour. It may involve any part of the skeleton but the most frequent parts are the ilium and diaphysis of femur and tibia (Alfeeli et al., 2005; Zhu et al., 2012). Primary ES of the spine is extremely rare (Yan et al., 2011). It accounts for only 3.5 to 14.9 percent of all primary bone sarcomas. The age of presentation ranges from 12 to 24 years (median 21 years) (Ferguson, 1999; Sharafuddin et al., 1992; Klimo Jr. et al., 2009). We report an unusual case of primary ES of the spine in a two-year-old boy, who presented to us with paraparesis and features of cauda equina syndrome...
2016: Case Reports in Orthopedics
https://www.readbyqxmd.com/read/27890514/effectiveness-of-radiolabelled-somatostatin-analogues-90-y-dotatoc-and-177-lu-dotatate-in-patients-with-metastatic-neuroendocrine-tumours-a-single-centre-experience-in-mexico
#3
S S Medina-Ornelas, F O García-Pérez
OBJECTIVE: To determine the effectiveness of therapy with the radiolabelled somatostatin analogues, (90)Y-DOTATOC and (177)Lu-DOTATATE, in the treatment of metastatic neuroendocrine tumours with progression to first-line treatment. MATERIAL AND METHODS: A study was conducted on 30 patients diagnosed with neuroendocrine tumours (gastroenteropancreatic, bronchopulmonary, MEN2A, MEN2B, phaeochromocytoma, and paraganglioma) with metastatic disease diagnosed by the pathology department, with progression to first-line treatment, and recruited from December 2014 to February 2016...
November 24, 2016: Revista Española de Medicina Nuclear e Imagen Molecular
https://www.readbyqxmd.com/read/27886674/pri-mir-34b-c-rs4938723-polymorphism-is-associated-with-the-risk-of-childhood-acute-lymphoblastic-leukemia
#4
Mohammad Hashemi, Gholamreza Bahari, Majid Naderi, Simin Sadeghi-Bojd, Mohsen Taheri
MicroRNAs (miRNAs), small noncoding regulatory RNAs, are key regulators of gene expression. The impact of Pri-miR-34b/c rs4938723 variant on development of various cancers is still controversial. In the present study, we examined whether a rs4938723 variant located at the promoter region of Pri-miR-34b/c is associated with childhood ALL. A total of 110 children with acute lymphoblastic leukemia (ALL) and 120 healthy children were recruited to participate in this study. The rs4938723 variant was genotyped by polymerase chain reaction restriction fragment length polymorphism (PCR-RFLP) method...
November 2016: Cancer Genetics
https://www.readbyqxmd.com/read/27882096/association-between-clusterin-gene-polymorphism-rs11136000-and-late-onset-alzheimer-s-disease-susceptibility-a-review-and-meta-analysis-of-case-control-studies
#5
Wenjin Du, Jiping Tan, Wei Xu, Jinwen Chen, Luning Wang
The present study aimed to evaluate the association between rs11136000 in clusterin (CLU) and late-onset Alzheimer's disease (LOAD) by meta-analysis. Several databases including PubMed, EMbase, CBMdisc and CMCC were searched for relevant case-control studies based on defined selection criteria. Odds ratios (OR) and 95% confidence interval (CI) of the rs11136000 genotype and allele distribution were analyzed with RevMan and Stata software. The control population and heterogeneity between populations were examined in the selected studies using the Hardy-Weinberg equilibrium...
November 2016: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/27876284/calculation-of-tumour-and-normal-tissue-biological-effective-dose-in-90-y-liver-radioembolization-with-different-dosimetric-methods
#6
Elena Gallio, Elisa Richetta, Monica Finessi, Michele Stasi, Riccardo Emanuele Pellerito, Gianni Bisi, Roberto Ropolo
PURPOSE: Radioembolization with (90)Y microspheres is an effective treatment for unresectable liver tumours. Two types of microspheres are available: resin (SIR-Spheres®) and glass (Theraspheres®). The aim of this study is to compare biological effective dose (BED) values obtained with three different dosimetric methods. METHODS: 29 HCC patients were included in this study: 15 were treated with resin(mean injected activity 1.5GBq, range 0.8-2.7GBq) and 14 with glass microspheres (2...
November 18, 2016: Physica Medica: PM
https://www.readbyqxmd.com/read/27874119/-99m-tc-conjugated-manganese-based-mesoporous-silica-nanoparticles-for-spect-ph-responsive-mri-and-anti-cancer-drug-delivery
#7
Hongbo Gao, Xiaohang Liu, Wei Tang, Dechao Niu, Bingni Zhou, Hua Zhang, Wei Liu, Bingxin Gu, Xiaobao Zhou, Yingying Zheng, Yiyun Sun, Xiaobo Jia, Liangping Zhou
In recent decades, hybrid imaging techniques that exploit the advantages of multiple imaging technologies have aroused extensive attention due to the deficiencies of single imaging modes. Along with the development of single photon emission computed tomography-magnetic resonance imaging (SPECT-MRI), it is currently necessary to develop a series of dual probes that can combine the outstanding sensitivity of SPECT with the high spatial resolution of MRI. Herein, the commonly used technetium-99 ((99m)Tc) was labelled on the surface of manganese oxide-based mesoporous silica nanoparticles (MnOx-MSNs) for use in SPECT-MRI dual-modal imaging...
December 1, 2016: Nanoscale
https://www.readbyqxmd.com/read/27862213/synthesis-and-preliminary-biological-evaluation-of-a-99m-tc-chlorambucil-derivative-as-a-potential-tumor-imaging-agent
#8
Jianguo Lin, Ling Qiu, Gaochao Lv, Ke Li, Wei Wang, Guiqing Liu, Xueyu Zhao, Shanshan Wang
Technetium-99 m-based radiopharmaceuticals have been used widely as diagnostic agents in the nuclear medicine. Chlorambucil (CLB) as one typical alkylating drug exhibits excellent inhibition effects against many human malignancies. In order to develop and explore a novel potential imaging agent for early diagnosis of tumors, tricarbonyl technetium-99 m and rhenium complexes based on the tridentate ligand dipicolylamine (DPA) bound to the chlorambucil pharmacophore were designed and synthesized: (99m) Tc-DPA-CLB (3) and Re-DPA-CLB (4)...
November 16, 2016: Journal of Labelled Compounds & Radiopharmaceuticals
https://www.readbyqxmd.com/read/27846041/factors-affecting-the-sensitivity-of-tc-99m-methoxyisobutylisonitrile-dual-phase-parathyroid-single-photon-emission-computed-tomography-in-primary-hyperparathyroidism
#9
Mine Araz, Derya Çayir, Mehmet Erdoğan, Bekir Uçan, Erman Çakal
OBJECTIVE: The aim of this study was to investigate the effects of thyroid diseases and regularly used medications on the sensitivity of Tc-99m methoxyisobutylisonitrile (MIBI) dual-phase parathyroid single photon emission computed tomography (SPECT) and to define indicatives of the result of the study. PATIENTS AND METHODS: Overall, 218 primary hyperparathyroidism patients (190 women, 28 men, mean age: 57±14 years) with thyroid-parathyroid ultrasonography and Tc-99m MIBI dual-phase parathyroid SPECT were retrospectively enrolled...
November 11, 2016: Nuclear Medicine Communications
https://www.readbyqxmd.com/read/27837548/left-ventricular-function-assessment-using-123-i-99m-tc-dual-isotope-acquisition-with-two-semi-conductor-cadmium-zinc-telluride-czt-cameras-a-gated-cardiac-phantom-study
#10
Tanguy Blaire, Alban Bailliez, Fayçal Ben Bouallegue, Dimitri Bellevre, Denis Agostini, Alain Manrique
BACKGROUND: The impact of increased energy resolution of cadmium-zinc-telluride (CZT) cameras on the assessment of left ventricular function under dual-isotope conditions ((99m)Tc and (123)I) remains unknown. The Amsterdam-gated dynamic cardiac phantom (AGATE, Vanderwilt techniques, Boxtel, The Netherlands) was successively filled with a solution of (123)I alone, (99m)Tc alone, and a mixture of (123)I and (99m)Tc. A total of 12 datasets was acquired with each commercially available CZT camera (DNM 530c, GE Healthcare and DSPECT, Biosensors International) using both energy windows ((99m)Tc or (123)I) with ejection fraction set to 33, 45, and 60 %...
December 2016: EJNMMI Physics
https://www.readbyqxmd.com/read/27834016/is-c-11-methionine-pet-ct-able-to-localise-sestamibi-negative-parathyroid-adenomas
#11
Theresia Weber, Martin Gottstein, Sabrina Schwenzer, Ambros Beer, Markus Luster
BACKGROUND: Patients with primary hyperparathyroidism (pHPT) and a negative preoperative Tc-99 sestamibi (MIBI) scintigraphy are considered to have a higher risk of persistent disease. The aim of this study was to assess whether additional imaging with C-11 methionine positron emission tomography/computed tomography (Met-PET/CT) is able to localise sestamibi-negative hyperfunctioning parathyroid glands. METHODS: In 50 patients (38 females, 12 males, age 13-81 years) with pHPT and negative localisation procedures such as ultrasound and sestamibi, a Met-PET/CT was performed before parathyroid surgery...
November 10, 2016: World Journal of Surgery
https://www.readbyqxmd.com/read/27833324/hepatocellular-carcinoma-with-intra-atrial-tumor-extension-identified-on-99m-tc-labeled-macroaggregated-albumin-single-photon-emission-computed-tomography-computed-tomography
#12
Piyush Chandra, Sneha Shah, Nilendu Purandare, Archi Agrawal, Venkatesh Rangarajan
(99)mTc macroaggregated albumin (MAA) scintigraphy is always performed before administration of (90)Y--microspheres for the treatment of liver tumors for hepatopulmonary shunt calculation. Tumor thrombus visualization in the hepatic vasculature is an infrequent finding on the (99)m Tc--MAA single photon emission computed tomography. We present a rare case of a hepatocellular carcinoma extending as a tumor thrombus through hepatic vein, inferior vena cava into the right atrium.
October 2016: Indian Journal of Nuclear Medicine: IJNM: the Official Journal of the Society of Nuclear Medicine, India
https://www.readbyqxmd.com/read/27833319/-99m-tc-methylene-diphosphonate-single-photon-emission-computed-tomography-computed-tomography-improves-the-diagnostic-accuracy-of-osteoid-osteoma
#13
Samuel Brian Squier, Jacob Ian Lewis, Joseph Matthew Accurso, Manoj Kumar Jain
We present a case of a 17-year-old football player who had previously received multiple facet joint injections for presumed secondary osteoarthritis. (99)mTc-methylene diphosphonate single-photon emission computed tomography/computed tomography imaging of the cervical spine demonstrated focal increased radiopharmaceutical activity in the right C2 lamina, which was associated with an osteolytic lesion with a central irregular sclerotic nidus. Surgical pathology confirmed an osteoid osteoma.
October 2016: Indian Journal of Nuclear Medicine: IJNM: the Official Journal of the Society of Nuclear Medicine, India
https://www.readbyqxmd.com/read/27833313/extraosseous-99m-tc-methylene-diphosphonate-uptake-on-bone-scan-unusual-scenario
#14
Shashwat Verma, Narvesh Kumar, Subhash Chand Kheruka, Sanjay Gambhir
In nuclear medicine, (99)mTc-methylene diphosphonate. (MDP) bone scan is one of the most commonly performed procedures. MDP uptake in nonosseous tissues is occasionally found in bone scan, and the knowledge of these kinds of extraosseous uptakes is of much clinical relevance. We report here two cases where bone scan showed extraosseous MDP uptake either hepatic or splenic apart from the physiological skeletal uptake.
October 2016: Indian Journal of Nuclear Medicine: IJNM: the Official Journal of the Society of Nuclear Medicine, India
https://www.readbyqxmd.com/read/27829576/mhealth-or-ehealth-efficacy-use-and-appreciation-of-a-web-based-computer-tailored-physical-activity-intervention-for-dutch-adults-a-randomized-controlled-trial
#15
Stefanie Gomez Quiñonez, Michel Jean Louis Walthouwer, Daniela Nadine Schulz, Hein de Vries
BACKGROUND: Until a few years ago, Web-based computer-tailored interventions were almost exclusively delivered via computer (eHealth). However, nowadays, interventions delivered via mobile phones (mHealth) are an interesting alternative for health promotion, as they may more easily reach people 24/7. OBJECTIVE: The first aim of this study was to compare the efficacy of an mHealth and an eHealth version of a Web-based computer-tailored physical activity intervention with a control group...
November 9, 2016: Journal of Medical Internet Research
https://www.readbyqxmd.com/read/27822851/spect-ct-comparison-of-lung-deposition-using-a-system-combining-a-vibrating-mesh-nebulizer-with-a-valved-holding-chamber-and-a-conventional-jet-nebulizer-a-randomized-cross-over-study
#16
Jonathan Dugernier, Michel Hesse, Rita Vanbever, Virginie Depoortere, Jean Roeseler, Jean-Bernard Michotte, Pierre-François Laterre, François Jamar, Gregory Reychler
PURPOSE: To compare in vivo the total and regional pulmonary deposition of aerosol particles generated by a new system combining a vibrating-mesh nebulizer with a specific valved holding chamber and constant-output jet nebulizer connected to a corrugated tube. METHODS: Cross-over study comparing aerosol delivery to the lungs using two nebulizers in 6 healthy male subjects: a vibrating-mesh nebulizer combined with a valved holding chamber (Aerogen Ultra®, Aerogen Ltd...
November 7, 2016: Pharmaceutical Research
https://www.readbyqxmd.com/read/27812743/glomerular-hyperfiltration-in-children-with-cancer-prevalence-and-a-hypothesis
#17
Neha S Kwatra, Holly J Meany, Sunil J Ghelani, David Zahavi, Nayan Pandya, Massoud Majd
BACKGROUND: Glomerular hyperfiltration has recently been reported in children with malignancies and has been attributed to increased solute from breakdown of tumor tissues. OBJECTIVE: To evaluate the prevalence of hyperfiltration in the pediatric oncology population and explore its pathophysiological mechanism. MATERIALS AND METHODS: Tc-99 m diethylenetriaminepentaacetic acid (DTPA) glomerular filtration rate (GFR) examinations (437 studies) and medical records of 177 patients <21 years of age diagnosed with a malignancy between January 2005 and October 2013 were retrospectively reviewed...
November 3, 2016: Pediatric Radiology
https://www.readbyqxmd.com/read/27799797/the-diagnostic-value-of-99-tc-m-2-2-methyl-5-nitro-1h-imidazol-1-yl-ethyl-dihydrogen-phosphate-hypoxia-imaging-and-its-evaluation-performance-for-radiotherapy-efficacy-in-non-small-cell-lung-cancer
#18
Yongkun Yang, Gaohua Han, Wansong Xu
BACKGROUND AND AIM: This study was designated to assess the diagnostic value of (99)Tc(M)-2-(2-methyl-5-nitro-1H-imidazol-1-yl) ethyl dihydrogen phosphate ((99)Tc(M)-MNLS) hypoxia imaging and its evaluation performance for radiotherapy efficacy in patients with non-small-cell lung cancer (NSCLC). PATIENTS AND METHODS: A total of 61 patients with NSCLC were selected for this study. All patients were injected with (99)Tc(M)-MNLS within 1 week prior to radiotherapy and they were injected with (99)Tc(M)-MNLS again 3 months after radiotherapy...
2016: OncoTargets and Therapy
https://www.readbyqxmd.com/read/27792232/technetium-incorporation-in-scheelite-insights-from-first-principles
#19
Matthew Ackerman, Eunja Kim, Philippe F Weck, Wendy Chernesky, Kenneth R Czerwinski
Atomistic investigations of crystalline scheelite, CaWO4, and (99)Tc-bearing scheelite, CaWO4:Tc, have been carried out using density functional theory. The lattice constants, bulk modulus, and volume compression data of CaWO4 have been calculated and compared with experimental data, with a focus on predictive understanding of (99)Tc incorporation in CaWO4. Defect formation energies have been computed for several possible interstitial (I) and substitutional (S) sites of (99)Tc in CaWO4. Both I(Oh) and S(W) sites were found to be energetically favourable for Tc doping...
October 28, 2016: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/27788707/-effect-of-jazf1-over-expression-on-high-fat-diet-induced-non-alcoholic-fatty-liver-disease
#20
W J Hu, W W Shen, X J Li, J Yao, Y J Jia, X Y Fan
Objective: To investigate the effects of juxtaposed with another zinc finger gene 1 (JAZF1) over-expression on the levels of pro-inflammatory cytokines in high-fat diet (HFD)-induced mouse fatty liver and its associated mechanisms. Methods: Twenty male C57BL/6J (3 weeks old) and 10 male JAZF1 transgenic (JAZF1-Tg) mice were randomly divided into three groups: wide-type with normal diet (NF group,n= 10), wide-type with high-fat diet (HF group,n= 10), and JAZF1-Tg with high-fat diet (HJ group,n= 10). All mice were fed with the corresponding diet for 12 weeks, and their food consumption and body weight were measured periodically...
August 20, 2016: Zhonghua Gan Zang Bing za Zhi, Zhonghua Ganzangbing Zazhi, Chinese Journal of Hepatology
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