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https://www.readbyqxmd.com/read/28533635/tc-99m-ethylenedicysteine-and-tc-99m-dimercaptosuccinic-acid-scintigraphy-comparison-of-the-two-for-detection-of-scarring-and-differential-cortical-function
#1
Anitha Dharmalingam, Shwetal U Pawar, Sandesh V Parelkar, Suruchi S Shetye, Mangala K Ghorpade, Gundu H Tilve
CONTEXT: The differential cortical function obtained by Tc-99m EC is comparable to that of Tc-99m DMSA. However, identification of scars on Tc-99m EC images needs to be studied. AIMS: The aim of the study is to evaluate role of Tc-99m EC for detection of scarring and differential cortical function by comparing with Tc-99m DMSA. SETTINGS AND DESIGN: Prospective observational study of recurrent UTI; minimum 6 weeks after acute episode; when urine examination is negative for pus cells...
April 2017: Indian Journal of Nuclear Medicine: IJNM: the Official Journal of the Society of Nuclear Medicine, India
https://www.readbyqxmd.com/read/28506974/assessment-of-reimbursement-in-a-community-hospital-based-pharmacist-managed-outpatient-transition-clinic
#2
Jinjie Huang, Ruthan Tattersall, Kristin Morse, Julia Nickerson-Troy, Elizabeth Clements, Lindsay Celauro, Amanda Lovell
PURPOSE: The assessment of reimbursement for and time spent on patient visits in a newly implemented, outpatient pharmacist-managed transition clinic (TC) was studied. METHODS: A retrospective chart review was conducted on clinic visits that occurred during January 1 to December 31, 2015. Patients who had at least one TC visit during the study period were included. Any visit with no response from insurance by March 31, 2016, was excluded. Services provided by the TC were billed using a facility fee billing model...
June 1, 2017: American Journal of Health-system Pharmacy: AJHP
https://www.readbyqxmd.com/read/28506419/radioguided-thyroidectomy-for-follicular-tumors-multicentric-experience
#3
D Parmeggiani, C Gambardella, R Patrone, A Polistena, M De Falco, R Ruggiero, R Cirocchi, A Sanguinetti, V Cuccurullo, M Accardo, N Avenia, G Docimo, S Tolone, V Bassi, L Docimo, G Conzo
BACKGROUND: The diagnosis of thyroid nodular diseases requires an integrated approach that has been widely established over the past years. This strategy includes: ultrasonography (US) with; implemented Color-Power-Doppler, conventional scintigraphy also with positive indicators, specific pathological studies targeted by immunohistochemically-assays, and the fine needle; aspiration biopsy (FNAB), which, usually, in case of "Follicular Lesions" (10-20%) findings is; unable to distinguish carcinoma from follicular adenoma, then indicating the necessity of surgery to; obtain a correct diagnosis...
May 2017: International Journal of Surgery
https://www.readbyqxmd.com/read/28492323/a-mixed-ring-sandwich-complex-from-unexpected-ring-contraction-in-re-%C3%AE-6-c6h5br-%C3%AE-6-c6r6-pf6
#4
Giuseppe Meola, Henrik Braband, Daniel Hernández-Valdés, Carla Gotzmann, Thomas Fox, Bernhard Spingler, Roger Alberto
The contraction of coordinated aromatic hydrocarbons is a rare reactivity pattern in organometallic chemistry. We describe the conversion of a bromobenzene coordinated to a Re(I) center into a cyclopentadienyl aldehyde. Under mildly alkaline conditions, the expected phenol complex is formed with Re and (99)Tc but under strong basic conditions; ring contraction occurs in close to quantitative yields for Re only. A mechanism for this unprecedented reaction is proposed based on (1)H and (2)H NMR spectra and density functional theory calculations...
May 11, 2017: Inorganic Chemistry
https://www.readbyqxmd.com/read/28478682/fully-automated-system-for-99-tc-monitoring-in-hospital-and-urban-residues-a-simple-approach-to-waste-management
#5
Marina Villar, Antoni Borràs, Jessica Avivar, Fernando Vega, Víctor Cerdà, Laura Ferrer
(99)Tc is an artificial beta emitter widely used in nuclear medicine for diagnostic tests. A fully automated and rapid system for (99)Tc monitoring is introduced with the aim to improve hospital residues management. This system can also be helpful for controlling urban wastewater. Figures of merit similar to those obtained with liquid scintillation counting were achieved by exploiting a simple, economic, and portable system with spectrophotometric detection. The combination of flow analysis techniques, i.e...
May 16, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/28460506/-clinical-characteristics-in-gout-patients-with-different-body-mass-index
#6
L D Ma, R X Sun, Y Xin, Y Wang, C G Li, T Liu, X Y Cheng, Z T Jia
Objective: Obesity is one of the risk factors for gout. The aim of the present study was to evaluate clinical characteristics of gout patients with different BMI. Methods: A total of 5 104 patients with gout were enrolled and divided into three groups according to the BMI. The clinical information was collected and relevant biochemical indices were detected. SPSS software was applied for the statistical analyses. Results: There were significant differences in the ratios of gender, regular exercise, hypertension, tophus, renal insufficiency, hyperlipidemia, impaired glucose metabolism, liver dysfunction among the three groups (all P<0...
May 1, 2017: Zhonghua Nei Ke za Zhi [Chinese Journal of Internal Medicine]
https://www.readbyqxmd.com/read/28458704/association-of-helicobacter-pylori-infection-with-metabolic-parameters-and-dietary-habits-among-medical-undergraduate-students-in-southeastern-of-iran
#7
Omid Eslami, Mansour Shahraki, Touran Shahraki, Hossein Ansari
BACKGROUND: To date, there is still inconclusive evidence on the extra-gastric manifestations of Helicobacter pylori (H.pylori) infection. This study aimed to determine whether there is an association between H.pylori infection with metabolic syndrome and dietary habits among medical undergraduate students in south-eastern of Iran, Zahedan. MATERIALS AND METHODS: This cross-sectional study was done among 363 undergraduate students in Zahedan University of Medical Sciences during spring 2014...
2017: Journal of Research in Medical Sciences: the Official Journal of Isfahan University of Medical Sciences
https://www.readbyqxmd.com/read/28443689/recent-achievements-in-tc-99m-radiopharmaceutical-direct-production-by-medical-cyclotrons
#8
Alessandra Boschi, Petra Martini, Micol Pasquali, Licia Uccelli
(99m)Tc is the most commonly used radionuclide in the field of diagnostic imaging, a noninvasive method intended to diagnose a disease, assess the disease state and monitor the effects of treatments. Annually, the use of (99m)Tc, covers about 85% of nuclear medicine applications. This isotope releases gamma rays at about the same wavelength as conventional X-ray diagnostic equipment, and owing to its short half-life (t½ = 6 hours) is ideal for diagnostic nuclear imaging. A patient can be injected with a small amount of (99m)Tc and within 24 hours almost 94% of the injected radionuclide would have decayed and left the body, limiting the patient's radiation exposure...
April 26, 2017: Drug Development and Industrial Pharmacy
https://www.readbyqxmd.com/read/28442395/association-of-genetic-variations-in-il-6-il-6r-pathway-genes-with-gastric-cancer-risk-in-a-chinese-population
#9
Jian-Zhi Zhang, Chang-Ming Liu, Hui-Ping Peng, Ying Zhang
Interleukin-6 (IL-6) and its receptor (IL-6R) were regarded to be responsible for the occurrence of gastric cancer for their regulation roles in the inflammation. The genetic variations in these two genes (IL-6: rs6949149, rs1800796, rs10499563 and IL-6R:rs2228145) have been suggested to be associated with gastric cancer risk. However, the published results were inconsistent among subjects of different ethnicity. To evaluate such an association in Chinese population, we carried out this case-control study based on 473 patients with gastric cancer and 474 healthy controls, whose genotype were detected by the Sequenom MassARRAY platform, and Helicobacter pylori infection was assessed by immunogold testing kit...
April 22, 2017: Gene
https://www.readbyqxmd.com/read/28434010/dynamic-analysis-of-kidney-function-and-its-correlation-with-nutritional-indicators-in-a-large-sample-of-hospitalized-elderly-patients
#10
Li Qingping, Wei Ribao, Wang Yang, Su Tingyu, Yang Xi, Huang Mengjie, Miao Hui, Chen Xiangmei
BACKGROUND The aim of this study was to analyze changes in kidney function and its correlation with nutritional metabolism indicators in hospitalized elderly patients in a large medical center over the past 7 years. MATERIAL AND METHODS The renal function of patients over 60 years old in the Chinese PLA General Hospital in 2008, 2011, and 2014 were comparatively analyzed. The hemoglobin, serum albumin, triglycerides, cholesterol, uric acid, and urea nitrogen data were collected and used as the nutritional metabolism indicators...
April 23, 2017: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/28423195/noninvasive-imaging-of-c-rgd-2-9r-as-a-potential-delivery-carrier-for-transfection-of-sirna-in-malignant-tumors
#11
Xue Qi Chen, Meng Liu, Rong Fu Wang, Ping Yan, Chun Li Zhang, Chao Ma, Qian Zhao, Lei Yin, Guang Yu Zhao, Feng Qin Guo
The purpose of our study was to develop and evaluate a novel integrin αv β3 -specific delivery carrier for transfection of siRNA in malignant tumors. We adopted arginine-glycine-aspartate (RGD) motif as a tissue target for specific recognition of integrin αν β3 . A chimaeric peptide was synthesized by adding nonamer arginine residues (9R) at the carboxy terminus of cyclic-RGD dimer, designated as c(RGD)2 -9R, to enable siRNA binding. To test the applicability of the delivery carrier in vivo, c(RGD)2 -9R was labeled with radionuclide of technetium-99 m...
April 18, 2017: Journal of Labelled Compounds & Radiopharmaceuticals
https://www.readbyqxmd.com/read/28411971/mdrd-or-ckd-epi-for-glomerular-filtration-rate-estimation-in-living-kidney-donors
#12
Carla Burballa, Marta Crespo, Dolores Redondo-Pachón, María José Pérez-Sáez, Marisa Mir, Carlos Arias-Cabrales, Albert Francés, Lluis Fumadó, Lluis Cecchini, Julio Pascual
INTRODUCTION: The evaluation of the measured Glomerular Filtration Rate (mGFR) or estimated Glomerular Filtration Rate (eGFR) is key in the proper assessment of the renal function of potential kidney donors. We aim to study the correlation between glomerular filtration rate estimation equations and the measured methods for determining renal function. MATERIAL AND METHODS: We analysed the relationship between baseline GFR values measured by Tc-(99)m-DTPA (diethylene-triamine-pentaacetate) and those estimated by the four-variable Modification of Diet in Renal Disease (MDRD4) and Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equations in a series of living donors at our institution...
April 12, 2017: Nefrología: Publicación Oficial de la Sociedad Española Nefrologia
https://www.readbyqxmd.com/read/28408704/changing-use-patterns-for-99m-tc-maa-from-2000-to-2015
#13
James A Ponto
Since the early 2000's, evaluation of pulmonary embolism (PE) has shifted from (99m)Tc macroaggregated albumin (MAA) perfusion lung scans to CT angiography (CTA). (99m)Tc MAA continues to be used in patients with contraindications to CTA and for other uses. A reduced number of MAA particles is used in patients with pulmonary hypertension (PH) or other risk factors. This study assessed the changing use patterns for (99m)Tc MAA by comparing snap-shots of procedures in 2000 and in 2015 in one institution. Methods: Records for all patients receiving (99m)Tc MAA in the year 2000 and in 2015 were reviewed, making note of the imaging procedure, any contraindication to CTA, and if a reduced number of MAA particles was used...
April 13, 2017: Journal of Nuclear Medicine Technology
https://www.readbyqxmd.com/read/28403948/association-between-early-pregnancy-vitamin-d-status-and-changes-in-serum-lipid-profiles-throughout-pregnancy
#14
Jaqueline Lepsch, Ilana Eshriqui, Dayana Rodrigues Farias, Juliana S Vaz, Amanda C Cunha Figueiredo, Amanda Rodrigues Amorim Adegboye, Alex Brito, Rana Mokhtar, Lindsay H Allen, Michael F Holick, Gilberto Kac
OBJECTIVE: To evaluate the associations between first trimester 25-hydroxyvitamin D [25(OH)D] status and changes in high-density lipoprotein cholesterol (HDL-c), low-density lipoprotein cholesterol (LDL-c), total cholesterol (TC), triglyceride (TG) concentrations, TG/HDL-c, and TC/HDL-c ratios throughout pregnancy. We hypothesized that first trimester 25(OH)D inadequacy is associated with lower concentrations of HDL-c and higher LDL-c, TC, TG, TG/HDL-c, and TC/HDL-c ratios throughout pregnancy...
May 2017: Metabolism: Clinical and Experimental
https://www.readbyqxmd.com/read/28387769/-99-tc-m-octreotide-scintigraphy-and-serum-eye-muscle-antibodies-in-evaluation-of-active-thyroid-associated-ophthalmopathy
#15
B Sun, Z Zhang, C Dong, Y Zhang, C Yan, S Li
PurposeAs an autoimmune inflammatory disorder, active thyroid-associated ophthalmopathy (TAO) is managed optimally by immunosuppression. In this study, we aimed to evaluate octreotide scintigraphy and the level of serum extraocular muscle antibodies in TAO activity.Patients and methodsThis prospective study comprised 304 patients with active TAO (the clinical activity score; CAS≥3), 73 with inactive TAO (CAS<3), 128 with Graves' disease (GD) without ophthalmopathy, and 100 healthy subjects. Moderate-to-severe active TAO patients (CAS≥5) received intravenous injection of methylprednisolone; mild active patients (3≤CAS≤4) received periocular injection of triamcinolone acetonide...
May 2017: Eye
https://www.readbyqxmd.com/read/28385932/can-we-predict-which-dysplastic-hips-will-require-acetabular-augmentation-during-total-hip-arthroplasty-based-on-pre-operative-radiographs
#16
A G Marsh, A Nisar, M El Refai, S Patil, R M D Meek
AIMS: The purpose of this study was to evaluate whether an innovative templating technique could predict the need for acetabular augmentation during primary total hip arthroplasty for patients with dysplastic hips. PATIENTS AND METHODS: We developed a simple templating technique to estimate acetabular component coverage at total hip arthroplasty, the True Cup: False Cup (TC:FC) ratio. We reviewed all patients with dysplastic hips who underwent primary total hip arthroplasty between 2005 and 2012...
April 2017: Bone & Joint Journal
https://www.readbyqxmd.com/read/28369797/the-likelihood-of-coliform-bacteria-in-nj-domestic-wells-based-on-precipitation-and-other-factors
#17
Nicholas A Procopio, Thomas B Atherholt, Sandra M Goodrow, Lori A Lester
The influence of precipitation on coliform bacteria detection rates in domestic wells was investigated using data collected through the New Jersey Private Well Testing Act. Measured precipitation data from the National Weather Service (NWS) monitoring stations was compared to estimated data from the Multisensor Precipitation Estimate (MPE) in order to determine which source of data to include in the analyses. A strong concordance existed between these two precipitations datasets; therefore, MPE data was utilized as it is geographically more specific to individual wells...
March 29, 2017: Ground Water
https://www.readbyqxmd.com/read/28351009/the-influence-of-citrate-and-oxalate-on-99-tc-vii-cs-np-v-and-u-vi-sorption-to-a-savannah-river-site-soil
#18
D Montgomery, K Barber, N Edayilam, K Oqujiuba, S Young, T Biotidara, A Gathers, M Danjaji, N Tharayil, N Martinez, B Powell
Batch sorption experiments were conducted with 0.5-50 ppb (99)Tc, (133)Cs, (237)Np and U in the presence and absence of citrate and/or oxalate in a 25 g/L Savannah River Site (SRS) soil suspension. Citrate and oxalate were the ligands of choice due to their relevancy to plant exudates, the nuclides were selected for their wide range of biogeochemical behavior, and the soil from SRS was selected as a model Department of Energy (DOE) site soil. Batch samples were continually mixed on a rotary shaker and maintained at a pH of approximately 5...
June 2017: Journal of Environmental Radioactivity
https://www.readbyqxmd.com/read/28340513/mendelian-randomisation-implicates-hyperlipidaemia-as-a-risk-factor-for-colorectal-cancer
#19
Henry Rodriguez-Broadbent, Philip J Law, Amit Sud, Kimmo Palin, Sari Tuupanen, Alexandra Gylfe, Ulrika A Hänninen, Tatiana Cajuso, Tomas Tanskanen, Johanna Kondelin, Eevi Kaasinen, Antti-Pekka Sarin, Samuli Ripatti, Johan G Eriksson, Harri Rissanen, Paul Knekt, Eero Pukkala, Pekka Jousilahti, Veikko Salomaa, Aarno Palotie, Laura Renkonen-Sinisalo, Anna Lepistö, Jan Böhm, Jukka-Pekka Mecklin, Nada A Al-Tassan, Claire Palles, Lynn Martin, Ella Barclay, Susan M Farrington, Maria N Timofeeva, Brian F Meyer, Salma M Wakil, Harry Campbell, Christopher G Smith, Shelley Idziaszczyk, Timothy S Maughan, Richard Kaplan, Rachel Kerr, David Kerr, Michael N Passarelli, Jane C Figueiredo, Daniel D Buchanan, Aung K Win, John L Hopper, Mark A Jenkins, Noralane M Lindor, Polly A Newcomb, Steven Gallinger, David Conti, Fred Schumacher, Graham Casey, Lauri A Aaltonen, Jeremy P Cheadle, Ian P Tomlinson, Malcolm G Dunlop, Richard S Houlston
While elevated blood cholesterol has been associated with an increased risk of colorectal cancer (CRC) in observational studies, causality is uncertain. Here we apply a Mendelian randomisation (MR) analysis to examine the potential causal relationship between lipid traits and CRC risk. We used single nucleotide polymorphisms (SNPs) associated with blood levels of total cholesterol (TC), triglyceride (TG), low-density lipoprotein (LDL), and high-density lipoprotein (HDL) as instrumental variables (IV). We calculated MR estimates for each risk factor with CRC using SNP-CRC associations from 9,254 cases and 18,386 controls...
March 24, 2017: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/28337529/the-impact-of-repeated-cycles-of-radioligand-therapy-using-177-lu-lu-psma-617-on-renal-function-in-patients-with-hormone-refractory-metastatic-prostate-cancer
#20
Anna Yordanova, Anja Becker, Elisabeth Eppard, Stefan Kürpig, Christian Fisang, Georg Feldmann, Markus Essler, Hojjat Ahmadzadehfar
BACKGROUND: [(177)Lu]Lu-PSMA-617 is a well-tolerated therapy for the treatment of metastatic prostate cancer. However, because of the mainly renal excretion of the tracer, the kidneys are one of the most limiting organs. The purpose of this study was to examine the post-therapeutic changes in renal function over time and to identify risk factors for developing renal toxicity. We also tested the reliability of markers for renal function monitoring. METHODS: Fifty-five patients with castrate-resistant metastatic prostate cancer treated with at least three cycles of [(177)Lu]Lu-PSMA-617 were investigated...
March 23, 2017: European Journal of Nuclear Medicine and Molecular Imaging
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