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https://www.readbyqxmd.com/read/28645090/the-impact-of-tidal-and-mesoscale-eddy-advection-on-the-long-term-dispersion-of-99-tc-from-sellafield
#1
Magne Simonsen, Øyvind Saetra, Pål Erik Isachsen, Ole Christian Lind, Hilde Kristin Skjerdal, Brit Salbu, Hilde Elise Heldal, Justin P Gwynn
In the present work, numerical models are used to study the fate of the (99)Tc discharges from Sellafield with a specific focus on the role of mesoscale eddy and tidal advection on the transport and dispersion of this radionuclide. Transport estimates are made with an ocean model that resolves a large part of the ocean mesoscale eddy field and also includes tides. Equivalent estimates are also computed with another model in which these processes are either absent or parametrized. Comparison with field observations shows that the coarse-resolution model can reproduce the general features of the observed time-space (99)Tc distribution if the diffusivity in its eddy parametrization scheme is suitably chosen...
June 20, 2017: Journal of Environmental Radioactivity
https://www.readbyqxmd.com/read/28622639/an-investigation-into-the-rapid-removal-of-tetracycline-using-multilayered-graphene-phase-biochar-derived-from-waste-chicken-feather
#2
Huiqin Li, Jingtao Hu, Yue Meng, Jinhua Su, Xiaojing Wang
This study investigated the removal of tetracycline (TC) using multilayered graphene-phase biochar (MGB) derived from waste chicken feather. MGB was produced through a two-stage carbonization and KOH-activation method. MGB was characterized by scanning electron microscopy (SEM), transmission electron microscope (TEM), Fourier transform infrared (FT-IR), Raman spectra, Zeta potential and elemental analysis. Various chemical functional groups were demonstrated on the surface of MGB. MGB was featured by a very large BET surface area of 1838m(2)/g...
June 13, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28622166/quantitative-analysis-of-iodine-image-of-dual-energy-computed-tomography-at-rest-comparison-with-99mtc-tetrofosmin-stress-rest-single-photon-emission-computed-tomography-myocardial-perfusion-imaging-as-the-reference-standard
#3
Takehiro Nakahara, Takuji Toyama, Masahiro Jinzaki, Ryotaro Seki, Yuichiro Saito, Tetsuya Higuchi, Minoru Yamada, Masashi Arai, Yoshito Tsushima, Sachio Kuribayashi, Masahiko Kurabayashi
PURPOSE: Dual-energy computed tomography (DECT) can be used for visual determination of iodine distribution in the myocardium (iodine image); however, the accuracy and reproducibility of the process remains debatable. Because of the low contrast-to-noise ratio of CT, we hypothesized that quantitative measurement may be more accurate for detecting myocardial ischemia. In this study, we evaluated our quantitative method by comparing it with visual analysis using Tc-tetrofosmin (TF) stress-rest single-photon emission computed tomography (SPECT) myocardial perfusion imaging (MPI) as the reference standard...
June 15, 2017: Journal of Thoracic Imaging
https://www.readbyqxmd.com/read/28599673/low-hdl-cholesterol-among-hiv-1-infected-and-hiv-1-uninfected-individuals-in-nairobi-kenya
#4
Anne Njoroge, B L Guthrie, Rose Bosire, Mark Wener, James Kiarie, Carey Farquhar
BACKGROUND: Antiretroviral treatment (ART) is associated with dyslipidemia yet little is known about the burden of dyslipidemia in the absence of ART in sub-Saharan Africa. We compared the prevalence and risk factors for dyslipidemia among HIV-infected ART-naïve adults and their uninfected partners in Nairobi, Kenya. METHODS: Non-fasting total cholesterol (TC) and high density lipoprotein cholesterol (HDL) levels were measured by standard lipid spectrophotometry on thawed plasma samples obtained from HIV-infected participants and their uninfected partners...
June 9, 2017: Lipids in Health and Disease
https://www.readbyqxmd.com/read/28575794/-99m-tc-labeled-psma-inhibitor-biokinetics-and-radiation-dosimetry-in-healthy-subjects-and-imaging-of-prostate-cancer-tumors-in-patients
#5
Clara Santos-Cuevas, Jenny Davanzo, Guillermina Ferro-Flores, Francisco O García-Pérez, Blanca Ocampo-García, Eleazar Ignacio-Alvarez, Edgar Gómez-Argumosa, Martha Pedraza-López
The prostate-specific membrane antigen (PSMA) is expressed in epithelial cells of the prostate and highly overexpressed in 95% of advanced prostate cancers. The aims of this study was to estimate the biokinetics and dosimetry of (99m)Tc-EDDA/HYNIC-iPSMA ((99m)Tc-labeled PSMA inhibitor) in eight healthy subjects and evaluate its usefulness as a tumor-imaging agent in eight prostate cancer patients. METHODS: (99m)Tc-EDDA/HYNIC-iPSMA was obtained from a lyophilized formulation with radiochemical purities >98%, determined by reversed-phase HPLC and ITLC-SG analyses...
May 25, 2017: Nuclear Medicine and Biology
https://www.readbyqxmd.com/read/28567292/euthyroid-athyroxinemia-a-novel-endocrine-syndrome
#6
Nicholas Woodhouse, Fatima Bahowairath, Omayma Elshafie
A 55-year-old female was referred with abnormal thyroid function tests (TFTs); the free thyroxine level (FT4) was undetectable <3.3 pmol/L (normal: 7.9-14.4), while her FT3, TSH and urinary iodine levels were normal. She was clinically euthyroid with a large soft lobulated goitre that had been present for more than thirty years. She received an injection of recombinant human TSH (rhTSH) following which there was a progressive rise of the FT3 and TSH levels to 23 pmol/L and >100 mIU/L respectively at 24 h, The FT4 however remained undetectable throughout...
2017: Endocrinology, Diabetes & Metabolism Case Reports
https://www.readbyqxmd.com/read/28559948/bone-scintigraphy-and-tenofovir-induced-osteomalacia-in-chronic-hepatitis-b
#7
Alex Khoo Cheen Hoe, Lee Yeong Fong
Tenofovir, used in the treatment of chronic hepatitis B and HIV, is known for its side effects on the kidneys and bones. We share interesting images of a patient with tenofovir-induced osteomalacia on Technetium-99 m hydroxymethyelene (Tc-99 m HDP) bone scintigraphy. Pattern recognition of this bone scintigraphy and correlation with the clinical history is essential to avoid misdiagnosis.
June 2017: Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/28559941/comparison-of-two-different-segmentation-methods-on-planar-lung-perfusion-scan-with-reference-to-quantitative-value-on-spect-ct
#8
Minseok Suh, Yeon-Koo Kang, Seunggyun Ha, Yong-Il Kim, Jin Chul Paeng, Gi Jeong Cheon, Samina Park, Young Tae Kim, Dong Soo Lee, E Edmund Kim, June-Key Chung
PURPOSE: Until now, there was no single standardized regional segmentation method of planar lung perfusion scan. We compared planar scan based two segmentation methods, which are frequently used in the Society of Nuclear Medicine, with reference to the lung perfusion single photon emission computed tomography (SPECT)/computed tomography (CT) derived values in lung cancer patients. METHODS: Fifty-five lung cancer patients (male:female, 37:18; age, 67.8 ± 10...
June 2017: Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/28553184/initial-experience-in-the-use-of-technetium-99-metastable-hydroxymethylene-diphosphonate-as-an-alternative-ventilation-agent-during-periods-of-interim-shortage
#9
Colin Raymond Young, Kalpna Prasad
Sporadic supply interruptions of select radiopharmaceuticals on the global market require consideration of alternative agents to support continuity of essential nuclear medicine examinations. During an acute shortage of Xenon-133 and technetium-99 metastable (Tc-99m) diethylene-triamine-pentaacetate (DTPA), our institution used aerosolized Tc-99m hydroxymethylene diphosphonate (HDP), a radiopharmaceutical traditionally used in bone scintigraphy, in lieu of traditional ventilation agents, for two cases of suspected pulmonary embolism...
April 2017: World Journal of Nuclear Medicine
https://www.readbyqxmd.com/read/28533635/tc-99m-ethylenedicysteine-and-tc-99m-dimercaptosuccinic-acid-scintigraphy-comparison-of-the-two-for-detection-of-scarring-and-differential-cortical-function
#10
Anitha Dharmalingam, Shwetal U Pawar, Sandesh V Parelkar, Suruchi S Shetye, Mangala K Ghorpade, Gundu H Tilve
CONTEXT: The differential cortical function obtained by Tc-99m EC is comparable to that of Tc-99m DMSA. However, identification of scars on Tc-99m EC images needs to be studied. AIMS: The aim of the study is to evaluate role of Tc-99m EC for detection of scarring and differential cortical function by comparing with Tc-99m DMSA. SETTINGS AND DESIGN: Prospective observational study of recurrent UTI; minimum 6 weeks after acute episode; when urine examination is negative for pus cells...
April 2017: Indian Journal of Nuclear Medicine: IJNM: the Official Journal of the Society of Nuclear Medicine, India
https://www.readbyqxmd.com/read/28506974/assessment-of-reimbursement-in-a-community-hospital-based-pharmacist-managed-outpatient-transition-clinic
#11
Jinjie Huang, Ruthan Tattersall, Kristin Morse, Julia Nickerson-Troy, Elizabeth Clements, Lindsay Celauro, Amanda Lovell
PURPOSE: The assessment of reimbursement for and time spent on patient visits in a newly implemented, outpatient pharmacist-managed transition clinic (TC) was studied. METHODS: A retrospective chart review was conducted on clinic visits that occurred during January 1 to December 31, 2015. Patients who had at least one TC visit during the study period were included. Any visit with no response from insurance by March 31, 2016, was excluded. Services provided by the TC were billed using a facility fee billing model...
June 1, 2017: American Journal of Health-system Pharmacy: AJHP
https://www.readbyqxmd.com/read/28506419/radioguided-thyroidectomy-for-follicular-tumors-multicentric-experience
#12
D Parmeggiani, C Gambardella, R Patrone, A Polistena, M De Falco, R Ruggiero, R Cirocchi, A Sanguinetti, V Cuccurullo, M Accardo, N Avenia, G Docimo, S Tolone, V Bassi, L Docimo, G Conzo
BACKGROUND: The diagnosis of thyroid nodular diseases requires an integrated approach that has been widely established over the past years. This strategy includes: ultrasonography (US) with; implemented Color-Power-Doppler, conventional scintigraphy also with positive indicators, specific pathological studies targeted by immunohistochemically-assays, and the fine needle; aspiration biopsy (FNAB), which, usually, in case of "Follicular Lesions" (10-20%) findings is; unable to distinguish carcinoma from follicular adenoma, then indicating the necessity of surgery to; obtain a correct diagnosis...
May 2017: International Journal of Surgery
https://www.readbyqxmd.com/read/28492323/a-mixed-ring-sandwich-complex-from-unexpected-ring-contraction-in-re-%C3%AE-6-c6h5br-%C3%AE-6-c6r6-pf6
#13
Giuseppe Meola, Henrik Braband, Daniel Hernández-Valdés, Carla Gotzmann, Thomas Fox, Bernhard Spingler, Roger Alberto
The contraction of coordinated aromatic hydrocarbons is a rare reactivity pattern in organometallic chemistry. We describe the conversion of a bromobenzene coordinated to a Re(I) center into a cyclopentadienyl aldehyde. Under mildly alkaline conditions, the expected phenol complex is formed with Re and (99)Tc but under strong basic conditions; ring contraction occurs in close to quantitative yields for Re only. A mechanism for this unprecedented reaction is proposed based on (1)H and (2)H NMR spectra and density functional theory calculations...
May 11, 2017: Inorganic Chemistry
https://www.readbyqxmd.com/read/28478682/fully-automated-system-for-99-tc-monitoring-in-hospital-and-urban-residues-a-simple-approach-to-waste-management
#14
Marina Villar, Antoni Borràs, Jessica Avivar, Fernando Vega, Víctor Cerdà, Laura Ferrer
(99)Tc is an artificial beta emitter widely used in nuclear medicine for diagnostic tests. A fully automated and rapid system for (99)Tc monitoring is introduced with the aim to improve hospital residues management. This system can also be helpful for controlling urban wastewater. Figures of merit similar to those obtained with liquid scintillation counting were achieved by exploiting a simple, economic, and portable system with spectrophotometric detection. The combination of flow analysis techniques, i.e...
June 6, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/28460506/-clinical-characteristics-in-gout-patients-with-different-body-mass-index
#15
L D Ma, R X Sun, Y Xin, Y Wang, C G Li, T Liu, X Y Cheng, Z T Jia
Objective: Obesity is one of the risk factors for gout. The aim of the present study was to evaluate clinical characteristics of gout patients with different BMI. Methods: A total of 5 104 patients with gout were enrolled and divided into three groups according to the BMI. The clinical information was collected and relevant biochemical indices were detected. SPSS software was applied for the statistical analyses. Results: There were significant differences in the ratios of gender, regular exercise, hypertension, tophus, renal insufficiency, hyperlipidemia, impaired glucose metabolism, liver dysfunction among the three groups (all P<0...
May 1, 2017: Zhonghua Nei Ke za Zhi [Chinese Journal of Internal Medicine]
https://www.readbyqxmd.com/read/28458704/association-of-helicobacter-pylori-infection-with-metabolic-parameters-and-dietary-habits-among-medical-undergraduate-students-in-southeastern-of-iran
#16
Omid Eslami, Mansour Shahraki, Touran Shahraki, Hossein Ansari
BACKGROUND: To date, there is still inconclusive evidence on the extra-gastric manifestations of Helicobacter pylori (H.pylori) infection. This study aimed to determine whether there is an association between H.pylori infection with metabolic syndrome and dietary habits among medical undergraduate students in south-eastern of Iran, Zahedan. MATERIALS AND METHODS: This cross-sectional study was done among 363 undergraduate students in Zahedan University of Medical Sciences during spring 2014...
2017: Journal of Research in Medical Sciences: the Official Journal of Isfahan University of Medical Sciences
https://www.readbyqxmd.com/read/28443689/recent-achievements-in-tc-99m-radiopharmaceutical-direct-production-by-medical-cyclotrons
#17
Alessandra Boschi, Petra Martini, Micol Pasquali, Licia Uccelli
(99m)Tc is the most commonly used radionuclide in the field of diagnostic imaging, a noninvasive method intended to diagnose a disease, assess the disease state and monitor the effects of treatments. Annually, the use of (99m)Tc, covers about 85% of nuclear medicine applications. This isotope releases gamma rays at about the same wavelength as conventional X-ray diagnostic equipment, and owing to its short half-life (t½ = 6 h) is ideal for diagnostic nuclear imaging. A patient can be injected with a small amount of (99m)Tc and within 24 h almost 94% of the injected radionuclide would have decayed and left the body, limiting the patient's radiation exposure...
May 15, 2017: Drug Development and Industrial Pharmacy
https://www.readbyqxmd.com/read/28442395/association-of-genetic-variations-in-il-6-il-6r-pathway-genes-with-gastric-cancer-risk-in-a-chinese-population
#18
Jian-Zhi Zhang, Chang-Ming Liu, Hui-Ping Peng, Ying Zhang
Interleukin-6 (IL-6) and its receptor (IL-6R) were regarded to be responsible for the occurrence of gastric cancer for their regulation roles in the inflammation. The genetic variations in these two genes (IL-6: rs6949149, rs1800796, rs10499563 and IL-6R: rs2228145) have been suggested to be associated with gastric cancer risk. However, the published results were inconsistent among subjects of different ethnicity. To evaluate such an association in Chinese population, we carried out this case-control study based on 473 patients with gastric cancer and 474 healthy controls, whose genotypes were detected by the Sequenom MassARRAY platform, and Helicobacter pylori infection was assessed by immunogold testing kit...
August 5, 2017: Gene
https://www.readbyqxmd.com/read/28434010/dynamic-analysis-of-kidney-function-and-its-correlation-with-nutritional-indicators-in-a-large-sample-of-hospitalized-elderly-patients
#19
Li Qingping, Wei Ribao, Wang Yang, Su Tingyu, Yang Xi, Huang Mengjie, Miao Hui, Chen Xiangmei
BACKGROUND The aim of this study was to analyze changes in kidney function and its correlation with nutritional metabolism indicators in hospitalized elderly patients in a large medical center over the past 7 years. MATERIAL AND METHODS The renal function of patients over 60 years old in the Chinese PLA General Hospital in 2008, 2011, and 2014 were comparatively analyzed. The hemoglobin, serum albumin, triglycerides, cholesterol, uric acid, and urea nitrogen data were collected and used as the nutritional metabolism indicators...
April 23, 2017: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/28423195/noninvasive-imaging-of-c-rgd-2-9r-as-a-potential-delivery-carrier-for-transfection-of-sirna-in-malignant-tumors
#20
Xue Qi Chen, Meng Liu, Rong Fu Wang, Ping Yan, Chun Li Zhang, Chao Ma, Qian Zhao, Lei Yin, Guang Yu Zhao, Feng Qin Guo
The purpose of our study was to develop and evaluate a novel integrin αv β3 -specific delivery carrier for transfection of siRNA in malignant tumors. We adopted arginine-glycine-aspartate (RGD) motif as a tissue target for specific recognition of integrin αν β3 . A chimaeric peptide was synthesized by adding nonamer arginine residues (9R) at the carboxy terminus of cyclic-RGD dimer, designated as c(RGD)2 -9R, to enable siRNA binding. To test the applicability of the delivery carrier in vivo, c(RGD)2 -9R was labeled with radionuclide of technetium-99 m...
April 18, 2017: Journal of Labelled Compounds & Radiopharmaceuticals
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