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Tc 99

Sara Fuentes, Andrés Gómez-Fraile, Isabel Carrillo-Arroyo, Daniel Cabezalí-Barbancho, Cristina Tordable-Ojeda
OBJECTIVES: In recent years, different studies have mentioned the recurrence of vesicoureteral reflux (VUR) endoscopically resolved, an exceptional event after open surgery. The aim of this study is to describe the evolution of the cases of recurrence identified in our center to assess the importance of this event. METHOD: We have identified the cases of VUR that recurred after successful endoscopic treatment in our anesdepartment. We have analyzed diagnostic tests, management and final outcome...
June 2018: Archivos Españoles de Urología
Yanjun Wu, Li Zhang, Jing Liang, Qinyang Jiang, Yafen Guo, Ganqiu Lan
AIMS/INTRODUCTION: Streptozotocin (STZ) is a permanent diabetogenic compound and often used in animal diabetes modeling. The aim of this study is to compare the liver transcriptome of type 2 diabetes models (T2DM) in Guangxi Bama Mini-pig (GBM pig) induced by STZ or Non-STZ. RESEARCH DESIGN AND METHODS: 22 female GBM pigs were divided into 4 groups. Ctr group (4 pigs): standard diets; DM1_HH group (10 pigs): high fat and high carbohydrate diets; DM2_HS group (4 pigs): high fat and high carbohydrate diets + STZ; DM3_SH group (4 pigs): STZ + high fat and high carbohydrate diets...
June 6, 2018: Gene
Ning-Hu Liu, Meng-Jie Dong, Hao Liu, Xi-Li Lu, Dan Tian, Jun Zhang, Jun Yang, Jun-Hui Sun, Li-Hua Wu, Jian-Li Bi, Bo Zhang
OBJECTIVE: The aim was to perform exploratory research on the application of technetium phytate (Tc-Phy) portal perfusion index (PPI) imaging in predicting the complications of hepatitis B cirrhosis and their severity. PATIENTS AND METHODS: A total of 65 hepatitis B cirrhosis patients were stratified, respectively, into three groups from classes A to C according to Child-Pugh scores and five groups from stages 1 to 5 according to the five-stage prognostic system...
June 6, 2018: Nuclear Medicine Communications
Sayandev Chatterjee, Gabriel B Hall, Mark H Engelhard, Yingge Du, Nancy M Washton, Wayne W Lukens, Sungsik Lee, Carolyn I Pearce, Tatiana G Levitskaia
Understanding fundamental Tc chemistry is important to both the remediation of nuclear waste and the reprocessing of nuclear fuel; however, current knowledge of the electronic structure and spectral signatures of low-valent Tc compounds significantly lags behind the remainder of the d-block elements. In particular, identification and treatment of Tc speciation in legacy nuclear waste is challenging due to the lack of reference data especially for Tc compounds in the less common oxidation states (I-VI). In an effort to establish a spectroscopic library corresponding to the relevant conditions of extremely high ionic strength typical for the legacy nuclear waste, compounds with the general formula of [ fac-Tc(CO)3 (OH2 )3- n (OH) n ]1- n (where n = 0-3) were examined by a range of spectroscopic techniques including 99 Tc/13 C NMR, IR, XPS, and XAS...
June 5, 2018: Inorganic Chemistry
Tiffany Crider, Derrick Eng, Pooja R Sarkar, Janet Cordero, John Claude Krusz, Subhendra N Sarkar
OBJECTIVE: MRI and CT scans are usually normal in mild traumatic brain injury (mTBI) although 15-20% of such patients suffer for months from fatigue, headache, anxiety, sleep and other disorders. mTBI is suspected to be a cerebrovascular injury, similar to moderate and severe TBI. Brain SPECT is more sensitive and shows perfusion abnormalities immediately after mTBI. This work explores the perfusion abnormalities for young patients suffering from fatigue several months after mTBI. PATIENTS AND METHODS: Twelve mTBI patients (age:8-36 yr, 4 male) with no history of fatigue prior to trauma were prospectively studied following onset of fatigue 6-12 months after mTBI utilizing 99 m-Tc ECD brain SPECT with early and delayed radiotracer imaging...
July 2018: Clinical Neurology and Neurosurgery
P van Hagen, R de Jonge, M I van Berge Henegouwen, G J Hötte, E P van der Stok, J Lindemans, J J B van Lanschot, B P L Wijnhoven
The aim of this study is to determine the prevalence and incidence of vitamin B12 deficiency after esophagectomy for cancer. It is unknown if patients after esophagectomy with gastric tube reconstruction are at an increased risk for vitamin B12 deficiency. A cross-sectional cohort (group A) and a prospective cohort (group B) of patients who underwent esophagectomy for cancer in two tertiary referral centers in the Netherlands were included. Serum levels of holo-transcobalamin (Holo-TC) and methyl malonic acid (MMA) were determined...
December 1, 2017: Diseases of the Esophagus: Official Journal of the International Society for Diseases of the Esophagus
Won-Seok Kim, Sangsoo Han, Jinmo Ahn, Wooyong Um
Batch adsorption, batch diffusion, and flow-through column experiments were conducted using groundwater and fractured rock collected in unsaturated zone to increase our understanding of sorption and transport behavior of radionuclides. Increasing Kd values were observed in the sequence 90 Sr, 99 Tc, and 3 H regardless of the geological media tested. For all sorbing radionuclides, Kd values for the fracture-filling/coating material were observed to be higher than those for without fracture-filling/coating material regardless of the groundwater...
May 23, 2018: Environmental Geochemistry and Health
Benjamin Hentze, Thomas Muders, Henning Luepschen, Enn Maripuu, Göran Hedenstierna, Christian Putensen, Marian Walter, Steffen Leonhardt
Electrical impedance tomography (EIT) is a noninvasive imaging modality that allows real-time monitoring of regional lung ventilation (V) in intensive care patients at bedside. However, for improved guidance of ventilation therapy it would be beneficial to obtain regional ventilation-to-perfusion ratio (V/Q) by EIT. In order to further explore the feasibility, we first evaluate a model-based approach, based on semi-negative matrix factorization and a gamma-variate model, to extract regional lung perfusion (Q) from EIT measurements...
May 24, 2018: Physiological Measurement
Małgorzata Wrzesień
BACKGROUND: A radiopharmaceutical is a combination of a non-radioactive compound with a radioactive isotope. Two isotopes: technetium- 99m (<sup>99m</sup>Tc) and fluorine-18 (<sup>18</sup>F) are worth mentioning on the rich list of isotopes which have found numerous medical applications. Their similarity is limited only to the diagnostic area of applicability. The type and the energy of emitted radiation, the half-life and, in particular, the production method demonstrate their diversity...
May 22, 2018: Medycyna Pracy
Christian Than, Laura Seidl, Danijel Tosovic, J Mark Brown
This study investigated test-retest reliability of mechanomyography (MMG) on lumbar paraspinal muscles. Healthy male and female subjects (mean ± standard deviation, 25 ± 9.4 years, BMI 21.8 ± 2.99, n = 34) were recruited. Two test sessions (one week apart) consisted of MMG (laser displacement sensor (LDS)) muscle evaluations over the 10 lumbar facet joints, and 2 bilateral sacral sites, in anatomical extension and flexion. Two-way repeated measures ANOVA with Tukey's post hoc showed no significant differences between testing sessions for the same position (p > 0...
May 12, 2018: Journal of Electromyography and Kinesiology
Qinghua Li, Rongqing Sun, Hongdi Lyu, Dexin Shen, Qing Hu, Haiwei Wang, Nannan Wang, Jin Yan, Jing Wang
OBJECTIVE: To observe the effect of different core temperatures (Tc) after heat strike on serum inflammatory cytokines and multiple organ dysfunction syndrome (MODS) in rat. METHODS: 120 male Sprague-Dawley (SD) rats were randomly divided into normal control group (n = 30) and heat strike group (n = 90). The rats in heat strike group were put into simulated thermal climate animal module after adaptive training. The module temperature was raised to 39 centigrade in 30 minutes with 65% humidity...
May 2018: Zhonghua Wei Zhong Bing Ji Jiu Yi Xue
A Nemcova, A Jirkovska, M Dubsky, R Bem, V Fejfarova, V Woskova, A Pysna, M Buncova
Perfusion scintigraphy with technetium-99-methoxy-isobutyl-isonitrile ((99m)Tc-MIBI) is often used for assessing myocardial function but the number of studies concerning lower limb perfusion is limited. The aim of our study was to assess whether (99m)Tc-MIBI was an eligible method for evaluation of the effect of cell therapy on critical limb ischemia (CLI) in diabetic patients. (99m)Tc-MIBI of calf muscles was performed before and 3 months after autologous cell therapy (ACT) in 24 diabetic patients with CLI...
May 10, 2018: Physiological Research
J L Fan, F P Wang, S Wang, X L Liu, X N Wu, W Chen, L P Chen, W X Li
Objective: Investigate the effects of inducible ppp2r1a knockout on main physiological function in adult mice and study the mechanism. Methods: Ppp2r1a(flox/flox) mice and CAGG-CreER mice were hybridized to obtain 20 CAGG-CreER ppp2r1a(flox/flox) and 20 mice in homozygous group. Two groups of mice were divided into 4 groups respectively, finally we got 8 groups with 5 mice in each group. Tamoxifen was injected intraperitoneally to acquire inducible ppp2r1a knockout mice. The knockout efficiency of PP2A Aα in vital organs was measured by Western blot...
May 6, 2018: Zhonghua Yu Fang Yi Xue za Zhi [Chinese Journal of Preventive Medicine]
James H Yiin, Jeri L Anderson, Stephen J Bertke, David J Tollerud
OBJECTIVE: To examine dose-response relationships between internal uranium exposures and select outcomes among a cohort of uranium enrichment workers. METHODS: Cox regression was conducted to examine associations between selected health outcomes and cumulative internal uranium with consideration for external ionizing radiation, work-related medical X-rays and contaminant radionuclides technetium (99 Tc) and plutonium (239 Pu) as potential confounders. RESULTS: Elevated and monotonically increasing mortality risks were observed for kidney cancer, chronic renal diseases, and multiple myeloma, and the association with internal uranium absorbed organ dose was statistically significant for multiple myeloma...
May 9, 2018: American Journal of Industrial Medicine
Sandor Demeter, Roman Szweda, Judy Patterson, Marine Grigoryan
Given potential worldwide shortages of fission sourced 99 Mo/99m Tc medical isotopes there is increasing interest in alternate production strategies. A neutron activated 99 Mo source was utilized in a single center phase III open label study comparing 99m Tc, as 99m Tc Methylene Diphosphonate ([99m Tc]Tc-MDP), obtained from solvent generator separation of neutron activation produced 99 Mo, versus nuclear reactor produced 99 Mo (e.g., fission sourced) in oncology patients for which an [99m Tc]Tc-MDP bone scan would normally have been indicated...
2018: Journal of Radioanalytical and Nuclear Chemistry
Mara M Watson, Ayman F Seliman, Valery N Bliznyuk, Timothy A DeVol
Water can become contaminated as a result of a leak from a nuclear facility, such as a waste facility, or from clandestine nuclear activity. Low-level on-line radiation monitoring is needed to detect these events in real time. A Bayesian control chart method, Shiryaev-Roberts (SR) procedure, was compared with classical methods, 3-σ and cumulative sum (CUSUM), for quantifying an accumulating signal from an extractive scintillating resin flow-cell detection system. Solutions containing 0.10-5.0 Bq/L of 99 Tc, as T99cO4 - were pumped through a flow cell packed with extractive scintillating resin used in conjunction with a Beta-RAM Model 5 HPLC detector...
April 30, 2018: Journal of Environmental Radioactivity
Amanda R Lawter, Whitney L Garcia, Ravi K Kukkadapu, Odeta Qafoku, Mark E Bowden, Sarah A Saslow, Nikolla P Qafoku
At the Hanford Site in southeastern Washington, discharge of radionuclide laden liquid wastes resulted in vadose zone contamination, providing a continuous source of these contaminants to groundwater. The presence of multiple contaminants (i.e., 99 Tc and 129 I) increases the complexity of finding viable remediation technologies to sequester contaminants in situ and protect groundwater. Although previous studies have shown the efficiency of zero valent iron (ZVI) and sulfur modified iron (SMI) in reducing mobile Tc(VII) to immobile Tc(IV) and iodate incorporation into calcite, the coupled effects from simultaneously using these remedial technologies have not been previously studied...
April 30, 2018: Science of the Total Environment
Y Watanabe, E Sharwood, B Goodwin, M K Creech, H Y Hassan, M G Netea, M Jaeger, A Dumitrescu, S Refetoff, T Huynh, R E Weiss
BACKGROUND: Congenital hypothyroidism (CH) has an incidence of approximately 1:3000, but only 15% have mutations in the thyroid hormone synthesis pathways. Genetic analysis allows for the precise diagnosis. CASE PRESENTATION: A 3-week old girl presented with a large goiter, serum TSH > 100 mIU/L (reference range: 0.7-5.9 mIU/L); free T4  < 3.2 pmol/L (reference range: 8.7-16 pmol/L); thyroglobulin (TG) 101 μg/L. Thyroid Tc-99 m scan showed increased radiotracer uptake...
May 2, 2018: BMC Medical Genetics
Yun-Dong Xie, Zi-Zhang Chen, Na Li, Wen-Fang Lu, Yan-Hong Xu, Yuan-Yuan Lin, Li-Hua Shao, Qiu-Tang Wang, Li-Ying Guo, Yu-Qiong Gao, Guang-De Yang, Yi-Ping Li, Xiao-Li Bian
Hydroxytyrosol (HT) is a natural polyphenol antioxidant that exists in olive oil. In the study of multifunctional hypolipidemic of nicotinic derivatives, we found that hydroxytyrosol nicotinate (HT-N) incorporation of niacin with HT displayed ?-glucosidase inhibitory activities in vitro, such as yeast ?-glucosidase (IC50 ?=?117.72??M) and rat intestinal ?-glucosidases maltase (IC50 ?=?31.86??M) and sucrase (IC50 ?=?22.99??M), and had a good control of postprandial blood glucose (PBG). HT-N shown significantly hypoglycemic action by 16...
March 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
Shinichiro Doi, Hiroshi Iwata, Hideki Wada, Takehiro Funamizu, Jun Shitara, Hirohisa Endo, Ryo Naito, Hirokazu Konishi, Shuta Tsuboi, Manabu Ogita, Tomotaka Dohi, Takatoshi Kasai, Shinya Okazaki, Kikuo Isoda, Katsumi Miyauchi, Hiroyuki Daida
OBJECTIVE: No nutritional index has been firmly established yet in patients with coronary artery disease (CAD). In this study, we propose a simple to calculate nutritional indicator in patients who underwent percutaneous coronary intervention (PCI) by using parameters routinely measured in CAD and evaluated its prognostic implication. METHODS: This study is a retrospective observational analysis of a prospective database. The subjects were consecutive 3567 patients underwent their first PCI between 2000 and 2013 at Juntendo University Hospital in Tokyo...
July 1, 2018: International Journal of Cardiology
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