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https://www.readbyqxmd.com/read/29031085/a-study-on-the-extrinsic-sensitivity-and-counting-efficiency-of-a-gamma-camera-for-a-cylindrical-source-and-a-rectangular-detector
#1
Rukiye Çakır Haliloğlu, Özlem Karadeniz, Hatice Durak
In this work, the extrinsic counting efficiency and extrinsic sensitivity of a cylindrical source and a gamma camera with a rectangular detector were determined using homogeneous Tc-99(m). Scattered radiation effects were evaluated by both analyzing the energy spectrum of (99m)Tc for the scatter fraction and plotting the extrinsic counting efficiency and sensitivity. It is found that the scattered fraction values increased with increasing source thickness. Calculated extrinsic sensitivity shows a gradually decreasing trend with increasing source thickness...
October 4, 2017: Applied Radiation and Isotopes
https://www.readbyqxmd.com/read/29028914/trajectory-of-total-cholesterol-in-the-last-years-of-life-over-age-80-years-cohort-study-of-99-758-participants
#2
Judith Charlton, Rathi Ravindrarajah, Shota Hamada, Stephen H Jackson, Martin C Gulliford
Background: Epidemiological studies suggest that lower total cholesterol (TC) may be associated with higher mortality. This study aimed to evaluate whether a decline in total cholesterol before death might account for the association of TC with mortality over age 80 years. Methods: Cohort study using primary care electronic health records of 99,758 participants aged 80 to 105 years from the UK Clinical Practice Research Datalink (CPRD). Hazard ratios (HR) for all-cause mortality were adjusted for age, gender, frailty, comorbidity, blood pressure and smoking...
September 27, 2017: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
https://www.readbyqxmd.com/read/28994595/pertechnetate-induced-addition-of-sulfide-in-small-olefinic-acids-formation-of-tco-dimercaptosuccinate-2-5-and-tco-mercaptosuccinate-2-3-analogues
#3
Kimberly M Reinig, Rachel Seibert, Daniel Velazquez, Jakob Baumeister, Firouzeh Najafi Khosroshahi, Wei Wycoff, Jeff Terry, John E Adams, Carol A Deakyne, Silvia S Jurisson
Technetium-99 ((99)Tc) is important to the nuclear fuel cycle as a long-lived radionuclide produced in ∼6% fission yield from (235)U or (239)Pu. In its most common chemical form, namely, pertechnetate ((99)TcO4(-)), it is environmentally mobile. In situ hydrogen sulfide reduction of pertechnetate has been proposed as a potential method to immobilize environmental (99)TcO4(-) that has entered the environment. Reactions of (99)TcO4(-) with sulfide in solution result in the precipitation of Tc2S7 except when olefinic acids, specifically fumaric or maleic acid, are present; a water-soluble (99)Tc species forms...
October 10, 2017: Inorganic Chemistry
https://www.readbyqxmd.com/read/28993832/-diagnostics-and-treatment-of-primary-hyperparathyroidism
#4
C Nies
Primary hyperparathyroidism is a disease that occurs more frequently than generally thought and is often overlooked. Classical symptoms are bone pain and osteoporosis, renal calculi and peptic ulcers. Many patients are asymptomatic or have unspecific complaints. It is easy to establish the biochemical diagnosis based on calcium and parathormone (PTH) levels and 24-h urine calcium excretion. The most sensitive localization procedures for parathyroid adenomas are sonography and Tc-99(m)-MIBI scintigraphy. The indication for surgery is undisputed in symptomatic patients; however, there is controversy concerning patients without classical symptoms...
October 9, 2017: Der Chirurg; Zeitschrift Für Alle Gebiete der Operativen Medizen
https://www.readbyqxmd.com/read/28952617/-tc-ii-no-trifluoroacetate-4f-2-synthesis-and-reactions
#5
S M Balasekaran, A Hagenbach, M Drees, U Abram
Fluoridotetrakis(trifluoroacetato)nitrosyltechnetate(ii) was prepared by the dissolution of Cs2[Tc(NO)F5] in trifluoroacetic acid and addition of (NBu4)F·3H2O. The compound crystallizes as a mixed Cs(+)/NBu4(+) salt in the form of green crystals. Unlike the [Tc(NO)F5](2-) salts, the product is soluble in organic solvents and can be used as a precursor for ongoing ligand exchange procedures with organic ligands. The corresponding reactions with triphenylphosphine (PPh3), 1,2-bis(diphenylphosphino)ethane (DPPE) or pyridyldiphenylphosphine (pyPPh2) give technetium(i) complexes of the compositions Cs[Tc(NO)(PPh3)2(CF3COO)2F], [Tc(NO)(DPPE)2(OOCCF3)](PF6) and [Tc(NO)(κN,P-pyPPh2)(κP-pyPPh2)(CF3COO)2]...
October 10, 2017: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/28938210/contribution-of-industrial-density-and-socioeconomic-status-to-the-spatial-distribution-of-thyroid-cancer-risk-in-hangzhou-china
#6
Xufeng Fei, Zhaohan Lou, George Christakos, Qingmin Liu, Yanjun Ren, Jiaping Wu
BACKGROUND: The thyroid cancer (TC) incidence in China has increased dramatically during the last three decades. Typical in this respect is the case of Hangzhou city (China), where 7147 new TC cases were diagnosed during the period 2008-2012. Hence, the assessment of the TC incidence risk increase due to environmental exposure is an important public health matter. METHODS: Correlation analysis, Analysis of Variance (ANOVA) and Poisson regression were first used to evaluate the statistical association between TC and key risk factors (industrial density and socioeconomic status)...
September 19, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28930871/reliability-and-measurement-error-of-tensiomyography-to-assess-mechanical-muscle-function-a-systematic-review
#7
Saúl Martín-Rodríguez, Irineu Loturco, Angus M Hunter, David Rodríguez-Ruiz, Diego Munguia-Izquierdo
Interest in studying mechanical skeletal muscle function through tensiomyography (TMG) has increased in recent years. This systematic review aimed to (a) report the reliability and measurement error of all TMG parameters [i.e., maximum radial displacement of the muscle belly (Dm), contraction time (Tc), delay time (Td), half-relaxation time (½ Tr), and sustained contraction time (Ts)] and (b) to provide critical reflection on how to perform accurate and appropriate measurements for informing clinicians, exercise professionals, and researchers...
September 11, 2017: Journal of Strength and Conditioning Research
https://www.readbyqxmd.com/read/28926500/occipital-lobe-and-posterior-cingulate-perfusion-in-the-prediction-of-dementia-with-lewy-body-pathology-in-a-clinical-sample
#8
Angus M J Prosser, Livia Tossici-Bolt, Christopher M Kipps
OBJECTIVE: The aim of this study was to investigate the diagnostic value of occipital lobe and posterior cingulate perfusion in predicting dopamine transporter imaging outcome using a quantitative measure of analysis. PATIENTS AND METHODS: In total, 99 patients with cognitive complaints who had undergone both technetium-99m-hexamethylpropyleneamine oxime single-photon emission computed tomography (Tc-HMPAO SPECT) and I ioflupane (I-FP-CIT also called DaTSCAN) imaging in a dementia diagnostic center were analyzed...
September 18, 2017: Nuclear Medicine Communications
https://www.readbyqxmd.com/read/28920466/annals-express-evaluation-of-common-paediatric-creatinine-based-glomerular-filtration-rate-gfr-estimating-equations-in-black-african-children-in-kwazulu-natal-south-africa
#9
Yashna Rampursat, Rajendra Bhimma, Elaene Naicker, Fozy Peer, Verena Gounden
Background The use of serum creatinine (S-Cr) equations for estimating glomerular filtration rate (GFR) is well known in adults and children. We evaluated the revised Schwartz creatinine based estimated GFR (eGFR) prediction equation in Black African children in KwaZulu-Natal, South Africa. Methods Review of medical records of all Black African patients aged 2-18 years old who have had GFR determined by intravenous Technetium-99m-diethylene-triamine-pentaacetate((9)(9)(m)Tc DTPA), for the period 1 January 2010 to 31 December 2014 at the Inkosi Albert Luthuli Central Hospital (IALCH), Durban, South Africa was performed...
January 1, 2017: Annals of Clinical Biochemistry
https://www.readbyqxmd.com/read/28916097/determination-of-99-tc-in-fresh-water-using-tru-resin-by-icp-ms
#10
Nicolas Guérin, Remi Riopel, Sheila Kramer-Tremblay, Nimal de Silva, Jack Cornett, Xiongxin Dai
Technetium-99 ((99)Tc) determination at trace level by inductively coupled plasma mass spectrometry (ICP-MS) is challenging because there is no readily available appropriate Tc isotopic tracer. A new method using Re as a recovery tracer to determine (99)Tc in fresh water samples, which does not require any evaporation step, was developed. Tc(VII) and Re(VII) were pre-concentrated on a small anion exchange resin (AER) cartridge from one litre of water sample. They were then efficiently eluted from the AER using a potassium permanganate (KMnO4) solution...
October 2, 2017: Analytica Chimica Acta
https://www.readbyqxmd.com/read/28900995/-association-between-genetic-polymorphisms-and-variation-of-imatinib-pharmacokinetics-in-gastrointestinal-stromal-tumors
#11
Haibo Qiu, Wei Zhuang, Xueding Wang, Min Huang, Zhiwei Zhou
OBJECTIVE: To investigate the influence of metabolic enzymes polymorphisms on variations of imatinib (IM) pharmacokinetics in gastrointestinal stromal tumors (GIST) patients. METHODS: Clinical data of 118 Chinese GIST patients receiving 400 mg/d IM at Sun Yat-sen University Cancer Center between 2014 and 2016 were retrospectively analyzed. The plasma concentration of imatinib mesylate(IM) and its main metabolic N-demethyl imatinib (NDI) were determined by LC-MS/MS...
September 25, 2017: Zhonghua Wei Chang Wai Ke za Zhi, Chinese Journal of Gastrointestinal Surgery
https://www.readbyqxmd.com/read/28881275/residence-time-effects-on-technetium-reduction-in-slag-based-cementitious-materials
#12
Yuji Arai, Brian A Powell, D I Kaplan
A long-term disposal of technetium-99 ((99)Tc) has been considered in a type of cementitious formulation, slag-based grout, at the U.S. Department of Energy, Savannah River Site, Aiken SC, U.S.A. Blast furnace slag, which contains S and Fe electron donors, has been used in a mixture with fly ash, and Portland cement to immobilize (99)Tc(VII)O4(-)(aq) in low level radioactive waste via reductive precipitation reaction. However the long-term stability of Tc(IV) species is not clearly understood as oxygen gradually diffuses into the solid structure...
August 23, 2017: Journal of Hazardous Materials
https://www.readbyqxmd.com/read/28827905/clinical-utility-of-tc-99m-mibi-spect-ct-for-preoperative-localization-of-parathyroid-lesions
#13
Zeynep Gozde Ozkan, Seher Nilgun Unal, Serkan Kuyumcu, Yasemin Sanli, Mehmet Fatih Gecer, Beyza Ozcinar, Yasemin Senyurek Giles, Yesim Erbil
We aimed to demonstrate the role of SPECT/CT in preoperative localization of parathyroid lesions in patients with hyperparathyroidism who had technetium-99m (Tc-99m) methoxyisobutylisonitrile (MIBI) dual-phase parathyroid scintigraphy. We evaluated retrospectively the scintigraphic data of 103 patients who had parathyroidectomy after Tc-99m MIBI dual-phase parathyroid scintigraphy with SPECT/CT. The planar and SPECT/CT images were evaluated separately to determine their efficacy in localizing parathyroid lesions...
August 2017: Indian Journal of Surgery
https://www.readbyqxmd.com/read/28821087/in-vivo-antihyperlipidemic-and-antioxidant-activity-of-porphyran-in-hyperlipidemic-mice
#14
Xiaomei Wang, Weida Li, Li Xiao, Chundong Liu, Huimin Qi, Zhongshan Zhang
The hypolipidemic and antioxidant effects of porphyran from the red algae Porphyra haitanensis as a dietary supplement were evaluated in mice. The levels of serum TC, TG and LDL-C in MP group increased significantly (p<0.05 or p<0.01) by 28.5%, 29.4% and 33.5% compared with the model group. These significant rises were accompanied by significant declines of plasma HDL-C by 21.6% compared with the model group. In addition, the liver content of malondialdehyde significantly decreased, while the superoxide dismutase, catalase, glutathione peroxidase activities significantly increased...
October 15, 2017: Carbohydrate Polymers
https://www.readbyqxmd.com/read/28811778/effects-of-blood-lipid-stability-on-progression-of-carotid-atherosclerosis
#15
Yu Ding, Bo Li, Feng Tian, Shanshan Zhou, Yundai Chen
OBJECTIVE: To evaluate the effects of blood lipid stability on progression of carotid atherosclerosis. METHODS: A total of 416 patients who had physical examination in our hospital annually from January 2010 to December 2015 were selected and divided into a progression group (n=216) and a non-progression group (n=200) according to the intima-media thickness measured by carotid ultrasound. The levels of lipid-related parameters within five years were retrospectively analyzed to calculate the smoothness index (SI = x±/s)...
May 2017: Pakistan Journal of Medical Sciences Quarterly
https://www.readbyqxmd.com/read/28810550/2d-sti-combined-with-gated-99-tc-m-mibi-mpi-for-the-diagnosis-of-myocardial-ischemia-in-hypercholesterolemia-patients
#16
Yi Song, Rui-Fang Zhang, Yu Liu
This study aimed to investigate the reliability of ultrasound two-dimensional speckle tracking imaging (2D-STI) for the evaluation of myocardial ischemia in familial hypercholesterolemia (FH) patients. We recruited 28 patients clinically diagnosed with homozygous familial hypercholesterolemia (HoFH) and subjected them to 2D-STI, gated transthoracic Doppler echocardiography (TTDE), and (99)Tc(m)-methoxyisobutylisonitrile myocardial perfusion imaging ((99)Tc(m)-MIBI MPI). The sensitivity, specificity and diagnostic accordance rate of TTDE and 2D-STI for myocardial ischemia in HoFH patients were compared with the (99)Tc(m)-MIBI scores...
August 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28807325/radioguided-surgery-in-primary-hyperparathyroidism-results-and-correlation-with-intraoperative-histopathologic-diagnosis
#17
Juan P Suárez, María L Domínguez, Francisco J de Santos, José M González, Nuria Fernández, Fidel J Enciso
INTRODUCTION AND OBJECTIVES: Radioguided surgery is a minimally invasive surgical technique for the treatment of primary hyperparathyroidism. The goals of our study were to evaluate the rate of success and compare the results with intraoperative histological analysis. METHODS: We retrospectively studied 84 patients with primary parathyroidism who had undergone radioguided surgery. All the patients had a positive parathyroid scintigraphy prior to surgery. An intravenous injection of Tc-99m sestamibi was administered before surgery, and radioguided location of the pathologic parathyroid tissue was performed using an intraoperative gamma probe, applying the "20% rule"...
August 11, 2017: Acta Otorrinolaringológica Española
https://www.readbyqxmd.com/read/28796034/the-association-between-xpg-polymorphisms-and-cancer-susceptibility-evidence-from-observational-studies
#18
REVIEW
Cuihong Han, Xiaoyi Huang, Ruixi Hua, Shujie Song, Lihua Lyu, Na Ta, Jinhong Zhu, Peixi Zhang
BACKGROUND: Exposure to environmental carcinogens can cause damages to DNA. If not properly repaired, the DNA damages may increase the risk of carcinogenesis. Xeroderma pigmentosum group G (XPG) gene is an essential gene in the nucleotide excision repair (NER) pathway. The association between XPG polymorphisms and cancer susceptibility has been the focus of attention in the molecular epidemiology of cancer. However, the conclusions have been divergent. Therefore, we conducted a comprehensive meta-analysis to precisely evaluate the association of 3 frequently investigated XPG polymorphisms (rs751402, rs873601, and rs2296147) with cancer risk...
August 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28795384/contribution-of-hepatobiliary-scintigraphy-in-assessing-alpps-most-suited-timing
#19
Stéphanie Truant, Clio Baillet, Anne Claire Deshorgue, Mehdi El Amrani, Damien Huglo, François-René Pruvot
To reduce post-hepatectomy liver failure (PHLF), associating liver partition and portal vein ligation for staged hepatectomy (ALPPS) has been recently developed for patients with a limited future remnant liver (FRL). Nevertheless, high morbi-mortality rates have been reported . The current study aimed to analyze the kinetics of FRL function in patients who were offered ALPPS. Serial SPECT (99 m)Tc-mebrofenin hepatobiliary scintigraphy (HBS) was performed in all patients before and after surgery as well as at inter-stage to quantitatively assess hepatic function [total liver (TL) and FRL]...
August 9, 2017: Updates in Surgery
https://www.readbyqxmd.com/read/28794654/retrospective-study-to-identify-trigeminal-cervical-ocular-referred-pain-as-a-new-causative-entity-of-ocular-pain
#20
Scheffer Cg Tseng, Anny Ms Cheng, Yao Fu
PURPOSE: To determine the prevalence and clinical characteristics of trigeminal-cervical (TC) ocular referred pain. METHODS: A retrospective study of 1,680 patients seen during 2002-2010 was performed in an ocular surface specialty center to identify patients with or without TC pain defined as ocular pain with ipsilateral trigger points located at the occipital region. Patients with refractory TC pain despite topical anesthetics and conventional treatments received interventional injection to each trigger point...
2017: Journal of Pain Research
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