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Spontaneous Abortion

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https://www.readbyqxmd.com/read/28444434/quantitative-anatomy-of-the-primary-ossification-center-of-the-femoral-shaft-in-human-fetuses
#1
Mariusz Baumgart, Marcin Wiśniewski, Magdalena Grzonkowska, Mateusz Badura, Bogdan Małkowski, Michał Szpinda
PURPOSE: Early clinical distinction of congenital defects in the femur is extremely important, as it determines the prognosis of the development of the lower limb. This study was performed to quantitatively examine the primary center of ossification in the femoral shaft with respect to its linear, planar, and volumetric parameters. MATERIALS AND METHODS: Using methods of CT, digital-image analysis, and statistics, the size of the primary ossification center of the femoral shaft in 47 spontaneously aborted human fetuses aged 17-30 weeks was studied...
April 25, 2017: Surgical and Radiologic Anatomy: SRA
https://www.readbyqxmd.com/read/28443481/impact-of-abnormal-dna-methylation-of-imprinted-loci-on-human-spontaneous-abortion
#2
Yudong Liu, Yan Tang, Desheng Ye, Weixu Ma, Shuxian Feng, Xuelan Li, Xingyu Zhou, Xin Chen, Shiling Chen
Currently, there is a growing concern regarding the safety of assisted reproductive technology (ART) due to increased risk of spontaneous abortion (SA) and imprinting disorders in ART-conceived offspring. Early investigations suggested that aberrant genetic imprinting may be related to pregnancy loss; however, few studies have used human tissue specimens. Here the DNA methylation patterns of 3 imprinted genes, including maternally inherited GRB10 and the paternally inherited IGF2 and PEG3 genes, were evaluated in human chorionic villus samples by pyrosequencing and bisulfite sequencing polymerase chain reaction...
January 1, 2017: Reproductive Sciences
https://www.readbyqxmd.com/read/28441992/safety-of-a-c1-inhibitor-concentrate-in-pregnant-women-with-hereditary-angioedema
#3
James Fox, Arthur B Vegh, Inmaculada Martinez-Saguer, Walter A Wuillemin, Jonathan Edelman, Debora Williams-Herman, Mikhail Rojavin, Tanja Rosenberg
BACKGROUND: Increased estrogen levels during pregnancy can exacerbate hereditary angioedema (HAE), yet disease and treatment ramifications remain poorly studied in pregnant women. OBJECTIVE: Data from the international Berinert Patient Registry were used to evaluate outcomes of pregnancies exposed to plasma-derived, pasteurized, nanofiltered C1-inhibitor concentrate (pnfC1-INH) during routine HAE management. METHODS: This observational registry, conducted between 2010 and 2014 at 30 U...
May 1, 2017: Allergy and Asthma Proceedings:
https://www.readbyqxmd.com/read/28431992/genomic-answers-for-recurrent-spontaneous-abortion-in-saudi-arabia-an-array-comparative-genomic-hybridization-approach
#4
Sajjad Karim, Hasan Salleh Jamal, Abdullraheem Rouzi, Mohammed Salleh M Ardawi, Hans-Juergen Schulten, Zeenat Mirza, Nuha A Alansari, Maha M Al-Quaiti, Heba Abusamra, Muhammad Imran Naseer, Rola Turki, Adeel Gulzar Chaudhary, Mamdooh Gari, Adel Mohammed Abuzenadah, Mohammed Hussain Al-Qhatani
To study the genomics/genetic factors associated with recurrent spontaneous abortion (RSA), as ∼50% of RSA are unexplained. However, chromosome abnormalities have been reported to play major role in RSA. We performed whole genome array-CGH based genomic analysis of forty four Saudi RSA patients to identify potential molecular and chromosomal abnormalities. We identified a total of 845 alterations, usually not detected by classic cytogenetic methods, in different genomic regions using a cut off value of -0...
April 18, 2017: Reproductive Biology
https://www.readbyqxmd.com/read/28429137/women-s-alcohol-consumption-and-cumulative-incidence-of-live-birth-following-in-vitro-fertilization
#5
L E Dodge, S A Missmer, K L Thornton, M R Hacker
OBJECTIVE: The objective of this study was to determine the effect of alcohol consumption on outcomes among women undergoing in vitro fertilization (IVF). DESIGN: This study is a retrospective cohort study. SETTING: This study was performed in a private academically affiliated IVF center. PATIENTS: Patients included women presenting for their first IVF cycle from July 2004 through October 2012. INTERVENTION: Women completed self-administered questionnaires before their first IVF cycle, which included report of usual alcohol consumption...
April 20, 2017: Journal of Assisted Reproduction and Genetics
https://www.readbyqxmd.com/read/28427089/editor-s-highlight-exposure-to-crvi-during-early-pregnancy-increases-oxidative-stress-and-disrupts-the-expression-of-antioxidant-proteins-in-placental-compartments
#6
Sakhila K Banu, Jone A Stanley, Kirthiram K Sivakumar, Robert J Taylor, Joe A Arosh, Robert C Burghardt
Epidemiologic studies document relationships between chromium VI (CrVI) exposure and increased risk of spontaneous abortion, stillbirth, preterm birth, and neonatal death in pregnant women. Environmental contamination with CrVI is a growing problem both in the United States and developing countries. CrVI is widely used in numerous industries. This study was designed to understand the mechanism of CrVI toxicity on placental oxidative stress and antioxidant (AOX) machinery. Pregnant mother rats were treated with or without CrVI (50 ppm K2Cr2O7) through drinking water from gestational day (GD) 9...
February 1, 2017: Toxicological Sciences: An Official Journal of the Society of Toxicology
https://www.readbyqxmd.com/read/28420494/molecular-regulation-and-role-of-angiogenesis-in-reproduction
#7
REVIEW
Momchil Rizov, Petya Andreeva, Ivanka Dimova
Angiogenesis is an essential process for proper functioning of the female reproductive system and for successful pregnancy realization. The multitude of factors required for physiological angiogenesis and the complexity of regulation of their temporal-spatial activities contribute to aberrations in human fertilization and pregnancy outcomes. In this study, we reviewed the current knowledge of the temporal expression patterns, functions, and regulatory mechanisms of angiogenic factors during foliculogenesis, early implantation/placentation and embryo development, as well as recurrent spontaneous abortions...
April 2017: Taiwanese Journal of Obstetrics & Gynecology
https://www.readbyqxmd.com/read/28418849/oncologic-and-obstetrical-outcomes-with-fertility-sparing-treatment-of-cervical-cancer-a-systematic-review-and-meta-analysis
#8
REVIEW
Qing Zhang, Wenhui Li, Margaux J Kanis, Gonghua Qi, Minghao Li, Xingsheng Yang, Beihua Kong
OBJECTIVE: The objectives of this study were to evaluate the rates of recurrence, survival and pregnancy, and characterize pregnancy outcomes of early-stage cervical cancer(eCC) treated with fertility-sparing methods such as cervical conization (CON) and radical trachelectomy(RT) with or without pelvic lymphadenectomy. STUDY DESIGN: This was a meta-analysis of observational studies analyzed by a random-effects model and a meta-regression to assess heterogeneity...
March 15, 2017: Oncotarget
https://www.readbyqxmd.com/read/28418090/natural-mortality-and-cause-of-death-analysis-of-the-captive-chimpanzee-pan-troglodytes-a-35-year-review
#9
REVIEW
Hannah Laurence, Shyamesh Kumar, Michael A Owston, Robert E Lanford, Gene B Hubbard, Edward J Dick
We present the spontaneous causes of mortality for 137 chimpanzees (Pan troglodytes) over a 35-year period. A record review of the pathology database was performed and a primary cause of mortality was determined for each chimpanzee. The most common causes of mortality were as follows: cardiomyopathy (40% of all mortalities), stillbirth/abortion, acute myocardial necrosis, chimpanzee-induced trauma, amyloidosis, and pneumonia. Five morphologic diagnoses accounted for 61% of mortalities: cardiomyopathy, hemorrhage, acute myocardial necrosis, amyloidosis, and pneumonia...
April 18, 2017: Journal of Medical Primatology
https://www.readbyqxmd.com/read/28412999/generation-of-an-induced-pluripotent-stem-cell-line-from-chorionic-villi-of-a-turner-syndrome-spontaneous-abortion
#10
Shagufta Parveen, M M Panicker, Pawan Kumar Gupta
A major cause of spontaneous abortions is chromosomal abnormality of foetal cells. We report the generation of an induced pluripotent stem cell line from the fibroblasts isolated from chorionic villi of an early spontaneously aborted foetus with Turner syndrome. The Turner syndrome villus induced pluripotent stem cell line is transgene free, retains the original XO karyotype, expresses pluripotency markers and undergoes trilineage differentiation. This pluripotent stem cell model of Turner syndrome should serve as a tool to study the developmental abnormalities of foetus and placenta that lead to early embryo lethality and profound symptoms like infertility in 45 XO survivors...
March 2017: Stem Cell Research
https://www.readbyqxmd.com/read/28403953/risk-factors-of-preterm-birth-in-france-in-2010-and-changes-since-1995-results-from-the-french-national-perinatal-surveys
#11
C Prunet, M Delnord, M-J Saurel-Cubizolles, F Goffinet, B Blondel
OBJECTIVES: To investigate risk factors of total, spontaneous and induced preterm birth in 2010 and differences between 1995 and 2010. MATERIAL AND METHODS: The national perinatal surveys are based on a representative sample of births in France. We selected live-born singletons (n=14,326 in 2010 and 12,885 in 1995) and used multiple regression analyses to calculate adjusted odds ratios (aOR) for maternal sociodemographic characteristics, obstetric history, prenatal care and smoking...
January 2017: J Gynecol Obstet Hum Reprod
https://www.readbyqxmd.com/read/28398707/fetal-exposure-to-montelukast-and-congenital-anomalies-a-population-based-study-in-denmark
#12
Clara Cavero-Carbonell, Anne Vinkel-Hansen, Mª José Rabanque-Hernández, Carmen Martos, Ester Garne
BACKGROUND: The objective was to study pregnancy outcomes between groups of Danish women, with pregnancy ending between 1998 and 2009, according to their exposure to montelukast. METHODS: Cross-sectional observational study in Danish women, selecting live births and stillbirths (Birth Registry) and spontaneous abortions and induced terminations (Patient Registry). Montelukast exposure was obtained from the Prescription Registry (ATC code R03DC03). Exposure period was from 3 months before the last menstrual period until the end of the first trimester...
April 3, 2017: Birth Defects Res
https://www.readbyqxmd.com/read/28397981/a-randomized-trial-of-local-endometrial-injury-during-ovulation-induction-cycles
#13
Medhat E E Helmy, Mohammad A Maher, Nabih I Elkhouly, Mahmoud Ramzy
OBJECTIVE: To investigate the effect of endometrial injury on pregnancy outcomes among infertile women taking clomifene citrate. METHODS: A prospective randomized trial was undertaken at an Egyptian hospital between January 26, 2015, and July 17, 2016. Eligible women (≥1 year primary/secondary/unexplained infertility, aged 20-35 years, day-2 follicle-stimulating hormone <12 IU/L, normal prolactin/thyroid function/uterine cavity, ≥1 patent tube, male partner with normal semen count and motility, 3 cycles of clomifene citrate without success) were randomly allocated (1:1) using computer-generated numbers into intervention (received endometrial injury on cycle day 15-24) or control groups (sham procedure)...
April 11, 2017: International Journal of Gynaecology and Obstetrics
https://www.readbyqxmd.com/read/28395596/plasminogen-activator-inhibitor-1-polymorphism-confers-a-genetic-contribution-to-the-risk-of-recurrent-spontaneous-abortion-an-updated-meta-analysis
#14
Zhan Huang, Wenqian Tang, Zhikun Liang, Qiaopei Chen, Mingyi Li, Yingfeng Li, Shaoxing Lao, Huimin Pan, Liying Huang, Min Huang, Xuehua Hu, Jiangyang Zhao
Various studies have investigated the risk of recurrent spontaneous abortion (RSA) with plasminogen activator inhibitor-1 ( PAI-1) 4G/5G polymorphism. However, the results have been somewhat contradictory. Therefore, an updated meta-analysis based on 31 studies (5617 cases and 3952 controls) was undertaken to clarify this relationship. The degree of RSA risk was estimated using the odds ratio (OR) and the 95% confidence interval (CI). Overall, the random effects OR was 1.464 (95% CI: 1.269-1.690) for 4G versus 5G, 2...
January 1, 2017: Reproductive Sciences
https://www.readbyqxmd.com/read/28394550/refractory-bradycardia-a-rare-complication-of-carboprost-tromethamine-for-induction-of-abortion
#15
Jasna Čerkez Habek, Dubravko Habek, Dario Gulin
We report a first case of refractory several-hour sinus bradycardia, a rare but already described side effect of intramuscular administration of carboprost tromethamine to induce abortion for medical indication in a patient without cardiovascular and other diseases. After administration of atropine sulfate 3x0.5 mg intravenously without effect, the patient‘s sinus rhythm spontaneously normalized as carboprost was eliminated from the body (it has a 3-hour half-life). It is reasonable to believe that the specific prostaglandin underlay the etiology of bradycardia...
June 2016: Acta Clinica Croatica
https://www.readbyqxmd.com/read/28387948/correlations-between-intimate-partner-violence-and-spontaneous-abortion-stillbirth-and-neonatal-death-in-rural-malawi
#16
Nisha Rao, Abigail Turner, Bryna Harrington, Patrick Nampandeni, Venson Banda, Alison Norris
OBJECTIVE: To characterize associations between intimate partner violence (IPV) and adverse delivery outcomes among married Malawian women. METHODS: In the present secondary analysis of an ongoing project investigating sexual and reproductive health decision making in rural, Lilongwe District, Malawi, married women who had experienced at least one pregnancy were interviewed between July 15, 2014, and February 25, 2015. Associations between physical IPV experienced with participants' current partners and history of adverse delivery outcomes (spontaneous abortions, stillbirths, and neonatal deaths) were examined using log-binomial regression...
April 7, 2017: International Journal of Gynaecology and Obstetrics
https://www.readbyqxmd.com/read/28387857/pregnancy-in-polymyositis-or-dermatomyositis-retrospective-results-from-a-tertiary-centre-in-china
#17
Zhiqiang Zhong, Fuan Lin, Jing Yang, Fengchun Zhang, Xiaofeng Zeng, Xin You
Objective: . To examine if patients with PM/DM are at higher risk of complicated pregnancies. Methods: . In a retrospective cohort in a large tertiary centre in North China, the outcomes of 144 pregnancies were evaluated in 62 women with PM/DM. Generalized linear mixed effect models were fitted to assess the effect of pregnancy occurring after disease on pregnancy outcomes including preterm birth (PTB), abortion (spontaneous or induced) and normal delivery. Adjustment for confounding factors including parity, maternal age and pregnancy-disease interval were achieved with a multivariable model...
April 5, 2017: Rheumatology
https://www.readbyqxmd.com/read/28384539/follow-up-after-early-medical-abortion-comparing-clinical-assessment-with-self-assessment-in-a-rural-hospital-in-northern-norway
#18
Carl-Gustav Mählck, Torbjörn Bäckström
OBJECTIVES: A follow-up study was performed on women who had requested medical abortions in a rural hospital in northern Norway to compare clinical assessment with self-assessment of early medical abortion in terms of safety. STUDY DESIGN: During the three-year study period, 392 women requested termination of pregnancy. After excluding those who changed their mind, those who had a spontaneous miscarriage, those who were referred to a central hospital for a two-stage abortion, and those who had the abortion performed surgically, 242 cases remained, and all the medical files were reviewed...
March 29, 2017: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/28383615/seroprevalence-of-hev-antibodies-in-a-sample-of-pregnant-women-in-the-city-of-messina
#19
V La Fauci, A Facciolà, R Riso, S Calimeri, D Lo Giudice, R Squeri
BACKGROUND: Hepatitis E virus (HEV) is widespread in developing countries and the disease is also increasing in the developed ones. This infection in pregnancy can cause spontaneous abortion and neonatal death in 56% of newborns. STUDY DESIGN: The study was conducted on a sample of 352 pregnant women, 326 Italian and 26 foreign, in order to confirm the presence of HEV in our territory, to analyze wrong habits of the population and to suggest preventive actions against the risk to contract the infection during pregnancy...
May 2017: Annali di Igiene: Medicina Preventiva e di Comunità
https://www.readbyqxmd.com/read/28381301/meanings-of-abortion-in-context-accounts-of-abortion-in-the-lives-of-women-diagnosed-with-breast-cancer
#20
Maggie Kirkman, Carmel Apicella, Jillian Graham, Martha Hickey, John L Hopper, Louise Keogh, Ingrid Winship, Jane Fisher
BACKGROUND: A breast cancer diagnosis and an abortion can each be pivotal moments in a woman's life. Research on abortion and breast cancer deals predominantly with women diagnosed during pregnancy who might be advised to have an abortion. The other-discredited but persistent-association is that abortions cause breast cancer. The aim here was to understand some of the ways in which women themselves might experience the convergence of abortion and breast cancer. METHODS: Among 50 women recruited from the Australian Breast Cancer Family Study and interviewed in depth about what it meant to have a breast cancer diagnosis before the age of 41, five spontaneously told of having or contemplating an abortion...
April 5, 2017: BMC Women's Health
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