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https://www.readbyqxmd.com/read/28318080/hepatitis-e-and-pregnancy-current-state
#1
REVIEW
María Teresa Pérez-Gracia, Beatriz Suay-García, María Luisa Mateos-Lindemann
Hepatitis E virus (HEV) is responsible for more than 50% of acute viral hepatitis cases in endemic countries. Approximately 2 billion individuals live in hepatitis E-endemic areas and, therefore, are at risk of infection. According to World Health Organization, HEV causes about 20.1 million infections and 70 000 deaths every year. In developing countries with poor sanitation, this disease is transmitted through contaminated water and is associated with large outbreaks, affecting hundreds or thousands of people...
March 20, 2017: Reviews in Medical Virology
https://www.readbyqxmd.com/read/28306725/maternal-vitamin-d-insufficiency-and-risk-of-adverse-pregnancy-and-birth-outcomes-a-systematic-review-and-meta-analysis-of-longitudinal-studies
#2
A Kofi Amegah, Moses K Klevor, Carol L Wagner
BACKGROUND: Three previous reviews on the association of vitamin D insufficiency in pregnancy with preterm birth (PTB) and stillbirth were limited in scope and deemed inconclusive. With important new evidence accumulating, there is the need to update the previous estimates and assess evidence on other clinically important outcomes such as spontaneous abortion and Apgar score. We conducted a systematic review and meta-analysis to evaluate the quality and strength of the available evidence on the relations between vitamin D nutritional status, and pregnancy and birth outcomes...
2017: PloS One
https://www.readbyqxmd.com/read/28302748/smc5-6-is-required-for-the-formation-of-segregation-competent-bivalent-chromosomes-during-meiosis-i-in-mouse-oocytes
#3
Grace Hwang, Fengyun Sun, Marilyn O'Brien, John J Eppig, Mary Ann Handel, Philip W Jordan
SMC complexes include three major classes: cohesin, condensin, and SMC5/6. However, the localization pattern and genetic requirements for the SMC5/6 complex during mammalian oogenesis had not previously been examined. In mouse oocytes, the SMC5/6 complex is enriched at the pericentromeric heterochromatin, and also localizes along chromosome arms during meiosis. The infertility phenotypes of females with a Zp3-Cre-driven conditional knockout (cKO) of Smc5 demonstrated that maternally expressed SMC5 protein is essential for early embryogenesis...
March 16, 2017: Development
https://www.readbyqxmd.com/read/28301909/thrombin-activatable-fibrinolysis-inhibitor-gene-polymorphism-tafi1040c-t-in-women-with-recurrent-spontaneous-abortion
#4
Nabil ElDanasori, Nelly Abulata, Iman A Shaheen, Alaa M ElGendy, Waleed El-Khayat
Recurrent spontaneous abortion (RSA) is defined as 3 or more consecutive pregnancy failures. Thrombin-activatable fibrinolysis inhibitor (TAFI) is a plasma zymogen that regulates both fibrinolysis and inflammation. The TAFI 1040C/T polymorphism could alter the circulating levels of TAFI with a reduced capacity to remove the fibrin clots from the circulation; therefore, it could be considered a molecular risk factor for RSA. The TAFI 1040C/T polymorphism was studied in 50 patients with RSA by polymerase chain reaction-restriction fragment length polymorphism technique and compared to 50 age- and gender-matched healthy volunteers as a control group to verify its possible association with RSA...
January 1, 2017: Clinical and Applied Thrombosis/hemostasis
https://www.readbyqxmd.com/read/28299234/different-sonographic-faces-of-ectopic-pregnancy
#5
Charu Chanana, Nishant Gupta, Itisha Bansal, Kusum Hooda, Pranav Sharma, Mohit Gupta, Darshan Gandhi, Yogesh Kumar
Vaginal bleeding in the first trimester has wide differential diagnoses, the most common being a normal early intrauterine pregnancy, with other potential causes including spontaneous abortion and ectopic pregnancy. The incidence of ectopic pregnancy is approximately 2% of all reported pregnancies and is one of the leading causes of maternal mortality worldwide. Clinical signs and symptoms of ectopic pregnancy are often nonspecific. History of pelvic pain with bleeding and positive β-human chorionic gonadotropin should raise the possibility of ectopic pregnancy...
2017: Journal of Clinical Imaging Science
https://www.readbyqxmd.com/read/28298162/expression-and-significance-of-dendritic-cells-and-th17-treg-in-serum-and-placental-tissues-of-patients-with-intrahepatic-cholestasis-of-pregnancy
#6
Xiang Kong, Yan Kong, Fangyuan Zhang, Tingting Wang, Xiaotong Zhu
PURPOSE: Dendritic cells (DCs) are involved in immune system, which can also regulate the differentiation of T helper 17 (Th17) and regulatory T cells (Treg). DCs and Th17/Treg participate in preeclampsia and recurrent spontaneous abortion (RSA), but there is still lack of research in intrahepatic cholestasis of pregnancy (ICP). The aim was to evaluate the expression and significance of CD83(+)DCs, CD1a(+)DCs, interleukin-17 (IL-17) and IL-35 in serum and placental tissues of patients with ICP...
March 15, 2017: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/28297732/frequency-of-chromosomal-abnormalities-in-products-of-conception
#7
Thaís Mesquita Alves Teles, Carolina Maria Marques de Paula, Mariana Gontijo Ramos, Helena B B L Martins da Costa, Cyntia Roberta Almeida Andrade, Sarah Abreu Coxir, Maria Lectícia Firpe Penna
Purpose To describe the frequencies of chromosomal abnormalities found in abortion material, and to observe its correlation to maternal age. Methods A retrospective study was conducted based on data obtained from the databank of a medical genetics laboratory in Belo Horizonte, MG, Brazil. A total of 884 results from products of conception analysis were included, 204 of which were analyzed by cytogenetics, and 680 by molecular biology based on quantitative fluorescence polymerase chain reaction (QF-PCR)...
March 15, 2017: Revista Brasileira de Ginecologia e Obstetrícia
https://www.readbyqxmd.com/read/28295470/preconception-tsh-levels-and-pregnancy-outcomes-a-population-based-cohort-study-in-184-611-women
#8
Shi Chen, Xiang Zhou, Huijuan Zhu, Hongbo Yang, Fengying Gong, Linjie Wang, Man Zhang, Yu Jiang, Chengsheng Yan, Jianqiang Li, Qing Wang, Shikun Zhang, Hui Pan
BACKGROUND: Whether subclinical hypothyroidism adversely impacts pregnancy outcomes is inconclusive, and limited data are available on the optimal TSH range in women planning pregnancy. OBJECTIVE: To investigate the association between maternal preconception TSH levels and pregnancy outcomes. DESIGN: Population-based cohort study. METHODS: From 2010 to 2012, the free National Pre-pregnancy Checkups Project recruited 248,501 pairs of volunteer couples across China, of which 184,611women, who subsequently became pregnant, were studied...
March 15, 2017: Clinical Endocrinology
https://www.readbyqxmd.com/read/28292826/arrhythmia-risk-and-%C3%AE-blocker-therapy-in-pregnant-women-with-long-qt-syndrome
#9
Kohei Ishibashi, Takeshi Aiba, Chizuko Kamiya, Aya Miyazaki, Heima Sakaguchi, Mitsuru Wada, Ikutaro Nakajima, Koji Miyamoto, Hideo Okamura, Takashi Noda, Toshifumi Yamauchi, Hideki Itoh, Seiko Ohno, Hideki Motomura, Yoshiharu Ogawa, Hiroko Goto, Takaomi Minami, Nobue Yagihara, Hiroshi Watanabe, Kanae Hasegawa, Akihiro Terasawa, Hitoshi Mikami, Kayo Ogino, Yukiko Nakano, Sato Imashiro, Yosuke Fukushima, Yoshimitsu Tsuzuki, Koko Asakura, Jun Yoshimatsu, Isao Shiraishi, Shiro Kamakura, Yoshihiro Miyamoto, Satoshi Yasuda, Takashi Akasaka, Minoru Horie, Wataru Shimizu, Kengo Kusano
BACKGROUND: Pregnancy is one of the biggest concerns for women with long QT syndrome (LQTS). OBJECTIVES: This study investigated pregnancy-related arrhythmic risk and the efficacy and safety of β-blocker therapy for lethal ventricular arrhythmias in pregnant women with LQTS (LQT-P) and their babies. METHODS: 136 pregnancies in 76 LQT-P (29±5 years old; 22 LQT1, 36 LQT2, one LQT3, and 17 genotype-unknown) were enrolled. We retrospectively analysed their clinical and electrophysiological characteristics and pregnancy outcomes in the presence (BB group: n=42) or absence of β-blocker therapy (non-BB group: n=94)...
March 14, 2017: Heart: Official Journal of the British Cardiac Society
https://www.readbyqxmd.com/read/28289463/antenatal-characteristics-of-roma-female-population-in-virovitica-podravina-county-croatia
#10
Jadranko Šegregur, Domagoj Šegregur
INTRODUCTION: This study reports about antenatal characteristics of Roma minority population. The study was designed to investigate data about health behaviours known to be associated with reproductive outcomes of Roma women that have very good living conditions and relatively high resource availability. METHODS: A retrospective study included 204 Roma and 408 non-Roma hospitalised singleton births that occurred in the Maternity Ward of the General Hospital Virovitica in the period from 1991 to 2010...
March 1, 2017: Zdravstveno Varstvo
https://www.readbyqxmd.com/read/28286178/vagus-nerve-stimulation-suppresses-acute-noxious-activation-of-trigeminocervical-neurons-in-animal-models-of-primary-headache
#11
Simon Akerman, Bruce Simon, Marcela Romero-Reyes
Vagus nerve stimulation (VNS) has been reported to be effective in the abortive treatment of both migraine and cluster headache. Using validated animal models of acute dural-intracranial (migraine-like) and trigeminal-autonomic (cluster-like) head pain we tested whether VNS suppresses ongoing and nociceptive-evoked firing of trigeminocervical neurons to explain its abortive effects in migraine and cluster headache. Unilateral VNS was applied invasively via hook electrodes placed on the vagus nerve. A single dose of ipsilateral or contralateral VNS, to trigeminal recording and dural-stimulating side, suppressed ongoing spontaneous and noxious dural-evoked trigeminocervical neuronal firing...
March 9, 2017: Neurobiology of Disease
https://www.readbyqxmd.com/read/28277142/effects-of-human-chorionic-gonadotropin-estradiol-and-progesterone-on-interleukin-18-expression-in-human-decidual-tissues
#12
Fang Wang, Hong Zhu, Bing Li, Mingxing Liu, Dan Liu, Meilian Deng, Yanming Wang, Xuefeng Xia, Qingping Jiang, Dunjin Chen
Interleukin (IL)-18 is a proinflammatory cytokine which mediates a myriad of inflammatory responses during pregnancy. Changes in IL-18 levels have been linked to complications during pregnancy. This study was designed to assess the effects of estradiol, human chorionic gonadotropin (hCG), and progesterone on IL-18 expression in human decidual tissues. Uterine deciduas from women with normal pregnancy, spontaneous abortion, and progesterone treated spontaneous abortion were collected, and the effects of hormones on the viability of decidual cells and IL-18 secretion were detected by MTT and ELISA assays...
February 11, 2017: Gynecological Endocrinology
https://www.readbyqxmd.com/read/28277115/does-premature-elevated-progesterone-on-the-day-of-trigger-increase-spontaneous-abortion-rates-in-fresh-and-subsequent-frozen-embryo-transfers
#13
Mae Healy, George Patounakis, Austin Zanelotti, Kate Devine, Alan DeCherney, Michael Levy, Micah J Hill
Recent evidence has shown elevated progesterone (P) advances the endometrium in fresh ART cycles, creating asynchrony with the embryo and thus implantation failure and decreased live birth rates. If the window of implantation is closing as the embryo attempts to implant, there may be difficulty with trophoblastic invasion, leading to failure of early pregnancies. Our objective was to evaluate if P on the day of trigger was associated with spontaneous abortion (SAB) rates in fresh ART transfers. This was a retrospective cohort study involving fresh autologous and FET cycles from 2011 to 2013...
March 2, 2017: Gynecological Endocrinology
https://www.readbyqxmd.com/read/28272721/the-study-of-the-relationship-between-aberrant-expression-of-hot-shock-protein-70-hsp70-and-spontaneous-abortion
#14
Y-B Peng, H Liu, S-H Huang, H Lai, Q Zhou, Y Luo, Z-Y Zhang, B-R Xi, X Ouyang
OBJECTIVE: The present study is aimed to explore the relationship between aberrant expression of heat shock protein 70 (HSP) and spontaneous abortion. PATIENTS AND METHODS: 50 patients with spontaneous abortion and 50 patients with induced abortion were continuously selected based on the nearest matching principle, and the proportion of age and gestational age was 1:1. The decidual tissues were obtained, and the cell apoptosis was determined by TUNEL assay. Further, the expression of HSP70 was assayed by immune-histochemical staining, and the expression of HSP70 mRNA was detected by the RT-PCR approach...
February 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/28264624/age-specific-ivf-outcomes-in-infertile-women-with-baseline-fsh-levels-%C3%A2-20-miu-ml
#15
Vitaly A Kushnir, Maxie Safdie, Sarah K Darmon, David F Albertini, David H Barad, Norbert Gleicher
INTRODUCTION: Infertile women with severely diminished ovarian reserve who have low birth chances with in vitro fertilization (IVF) are often denied treatment with autologous oocytes. This study was designed to determine age-specific treatment efficacy and clinical characteristics of infertile women with severely diminished ovarian reserve who had live birth following IVF with autologous oocytes. METHODS: This retrospective cohort study investigated 291 infertile women who underwent 482 IVF cycles with autologous oocytes during 2004 to 2016 at our academically affiliated private fertility center...
January 1, 2017: Reproductive Sciences
https://www.readbyqxmd.com/read/28262231/antiphospholid-antibodies-and-the-risk-of-pregnancy-complications
#16
Jean-Christophe Gris, Sylvie Bouvier, Eva Nouvellon, Géraldine Lissalde-Lavigne, Erick Mercier, Jean-Pierre Balducchi, Pierre Marès
Antiphospholipid antibodies (APLAbs) are generally considered as risk factors for foetal death, for premature birth ≤34weeks due to severe pre-eclampsia or severe placental insufficiency and for recurrent consecutive spontaneous abortions <10weeks. Among these three obstetrical morbidities, only the first one is however not regularly questioned. The coexistence of an inflammatory disease and/or of thrombotic manifestations increases the obstetrical risks. Among the three criteria APLAbs, i.e. lupus anticoagulant (LA), anticardiolipin (aCL) Abs, anti-β2 glycoprotein-I (aβ2GP1)Abs, LA seems the more widely associated to clinical risks, the clinical impact of aβ2GP1Abs is progressively defined and the pejorative impact of triple positivity is still discussed...
March 2017: Thrombosis Research
https://www.readbyqxmd.com/read/28259178/factors-associated-with-spontaneous-abortion-a-cross-sectional-study-of-chinese-populations
#17
Danni Zheng, Chunyan Li, Taiwen Wu, Kun Tang
BACKGROUND: Spontaneous abortion (SA) is one of the prevalent negative reproductive outcomes among women around the world, which is a great challenge faced by maternal health promotion. The present study is aimed to explore the association between SA and socioeconomic status (SES) and provides reference for policy makers to improve strategies on maternal health promotion. METHODS: A cross-sectional analysis was conducted with baseline data from a large-scale population-based cohort study of 0...
March 4, 2017: Reproductive Health
https://www.readbyqxmd.com/read/28258586/pre-implantation-genetic-screening-among-women-experiencing-recurrent-failure-of-in-vitro-fertilization
#18
Safak Hatirnaz, Alev Ozer, Ebru Hatirnaz, Melahat Atasever, Serdar Başaranoglu, Mine Kanat-Pektas, Murat Api
OBJECTIVE: To determine the efficiency of pre-implantation genetic screening (PGS) among women scheduled to undergo intracytoplasmic sperm injection who had experienced recurrent in vitro fertilization (IVF) failure. METHODS: The present retrospective cohort study reviewed the medical records of consecutive women who had experienced recurrent IVF failure and had presented at a private IVF facility in Trabzon Province, Turkey, to undergo intracytoplasmic sperm injection between May 1, 2012, and December 31, 2014...
March 3, 2017: International Journal of Gynaecology and Obstetrics
https://www.readbyqxmd.com/read/28256367/impact-of-systemic-lupus-erythematosus-on-maternal-and-fetal-outcomes-following-pregnancy-a-meta-analysis-of-studies-published-between-years-2001-2016
#19
REVIEW
Pravesh Kumar Bundhun, Mohammad Zafooruddin Sani Soogund, Feng Huang
BACKGROUND: Previous research has already shown systemic lupus erythematosus (SLE) to have severe consequences on pregnancy outcomes. However, insufficient number of participants, which were mainly limited to one particular region, limited outcomes analyzed and lack of evidence based analysis to support systematic reviews of the literature were the limitations observed. Therefore, by improving these limitations, we aimed to systematically show the impact of SLE on maternal and fetal outcomes following pregnancy...
February 27, 2017: Journal of Autoimmunity
https://www.readbyqxmd.com/read/28254221/progesterone-estradiol-ratio-0-25-on-the-day-of-human-chorionic-gonadotropin-administration-is-associated-with-adverse-pregnancy-outcomes-in-prolonged-protocols-for-in%C3%A2-vitro-fertilization-intracytoplasmic-sperm-injection
#20
Yuan Li, Keli Luo, Yi Tang, Ge Lin, Guangxiu Lu, Fei Gong
OBJECTIVE: It has been suggested that a progesterone/estradiol ratio (P/E2) ≥ 1.0 on the day of human chorionic gonadotropin (hCG) administration indicates premature luteinization and might be associated with an adverse pregnancy; however, a lower limit of this ratio has not been determined. We aimed to identify a lower limit of P/E2 that correlates significantly with an increase in adverse pregnancies in patients undergoing a prolonged in vitro fertilization/intracytoplasmic sperm injection therapy...
February 2017: Taiwanese Journal of Obstetrics & Gynecology
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