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Spontaneous Abortion

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https://www.readbyqxmd.com/read/29334801/bu-shen-yi-qi-formula-impairs-cytotoxicity-of-nk-cells-by-up-regulating-ido-expression-in-trophoblasts
#1
Shao-Liang Yang, Tian-Tian Niu, Xue-Lian Li, Da-Jin Li, Ming-Qing Li, Hai-Yan Wang
Recurrent spontaneous abortion (RSA) is a common health problem that affects about 5% of fertile women, when it occurs for unknown reasons, it is called unexplained recurrent spontaneous abortion (URSA). Traditional Chinese medicine, such as Bu-Shen-Yi-Qi formula which consists of Dangshen, Tusizi, Baizhu, Baishuo, Duzhong, Sangjisheng, Sugeng, and Tiaohuangqin, has played an invaluable role in the treatment of RSA since ancient times. However, the mechanism of how it takes effect is still not clear. To identify Bu-Shen-Yi-Qi formula could modulate immune condition at maternal-fetal interface via its effect on trophoblasts, HTR-8 of different treatment were co-cultured with peripheral or decidual natural killer (NK) cells, and the receptors such as NKP30 and NKP46 expression on NK cells were measured by flow cytometry (FCM)...
January 15, 2018: Gynecological Endocrinology
https://www.readbyqxmd.com/read/29334203/modeling-in-vitro-fertilization-data-considering-multiple-outcomes-observed-among-iranian-infertile-women
#2
Azadeh Ghaheri, Aliakbar Rasekhi, Reza Omani Samani, Ebrahim Hajizadeh
Background: Women undergoing in vitro fertilization (IVF) cycles should successfully go through multiple points during the procedure (i.e., implantation, clinical pregnancy, no spontaneous abortion and delivery) to achieve live births. In this study, data from multiple cycles and multiple points during the IVF cycle are collected for each individual to model the effects of factors associated with success at different stages of IVF cycles in Iranian infertile women. MATERIALS AND METHODS: This historical cohort study includes 996 assisted reproductive technology (ART) cycles of 511 infertile women...
April 2018: International Journal of Fertility & Sterility
https://www.readbyqxmd.com/read/29326375/group-b-streptococcus-septic-arthritis-of-the-hip-following-spontaneous-abortion
#3
Madeline Lyons, Elizabeth Zielinski, Jibanananda Satpathy
Group B streptococcus (GBS) infection of the hip in otherwise healthy adults is a rare entity that is previously only reported following peripartum gynaecological procedure and instrumentation. We report a case of infection of the hip with GBS following spontaneous abortion. Delay in identification of infection as the cause of pain ultimately leads to irreversible joint destruction. This case report will heighten the awareness of the first contact providers as well as orthopaedic surgeons to be more vigilant for possible septic complications associated with gynaecological procedures/complications and subsequent painful joints...
January 11, 2018: BMJ Case Reports
https://www.readbyqxmd.com/read/29325638/implantable-cardioverter-defibrillators-in%C3%A2-children-and-adolescents-with-brugada%C3%A2-syndrome
#4
M Cecilia Gonzalez Corcia, Juan Sieira, Gudrun Pappaert, Carlo de Asmundis, Gian Battista Chierchia, Mark La Meir, Andrea Sarkozy, Pedro Brugada
BACKGROUND: Young patients presenting with symptomatic Brugada syndrome have very high risks for ventricular arrhythmias and should be carefully considered for implantable cardioverter-defibrillator (ICD) placement. However, this therapy is associated with high rates of inappropriate shocks and device-related complications. OBJECTIVES: This study investigated clinical features, management, and long-term follow-up of young patients with Brugada syndrome and ICD. METHODS: Patients diagnosed with Brugada syndrome, who underwent implantation of an ICD at an age of ≤20 years, were studied...
January 16, 2018: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/29324606/obstetric-outcomes-after-failed-hysteroscopic-and-laparoscopic-sterilization-procedures
#5
Kristyn Brandi, Jake R Morgan, Michael K Paasche-Orlow, Rebecca B Perkins, OʼConnell Katharine White
OBJECTIVE: To compare obstetric outcomes after failed hysteroscopic and laparoscopic sterilization. METHODS: This retrospective cohort study examined pregnancy outcomes including live birth, preterm birth, stillbirth, spontaneous abortion, therapeutic abortion, ectopic pregnancies, and gestational trophoblastic disease using a commercial claims administrative database for the years 2007-2013. We used a Z-test to compare pregnancy outcomes per 100 person-years based on type of sterilization...
January 9, 2018: Obstetrics and Gynecology
https://www.readbyqxmd.com/read/29317300/mesenchymal-stem-cells-therapy-protects-fetuses-from-resorption-and-induces-th2-type-cytokines-profile-in-abortion-prone-mouse-model
#6
Amir Salek Farrokhi, Amir-Hassan Zarnani, Seyed Mohammad Moazzeni
The imbalance of Th1/Th2 cytokines is well known in recurrent spontaneous abortion (RSA) mouse model. Mesenchymal stem cells (MSCs) possess potent immunoregulatory properties that could modulate the Th1 cytokine responses in benefit of Th2 types. In this study, we aimed to analyze the local and systemic balance of Th1/Th2 cytokines following MSCs therapy. Syngeneic adipose derived MSCs were administered to abortion prone mice during the implantation window. The abortion rate was determined and IL-4, IL-6, IL-12, IL-2, IFN-γ and GM-CSF gene expression was evaluated by Real-Time-PCR in decidual and placental tissues of pregnant mice at day 13...
January 6, 2018: Transplant Immunology
https://www.readbyqxmd.com/read/29305462/type-i-interferons-instigate-fetal-demise-after-zika-virus-infection
#7
Laura J Yockey, Kellie A Jurado, Nitin Arora, Alon Millet, Tasfia Rakib, Kristin M Milano, Andrew K Hastings, Erol Fikrig, Yong Kong, Tamas L Horvath, Scott Weatherbee, Harvey J Kliman, Carolyn B Coyne, Akiko Iwasaki
Zika virus (ZIKV) infection during pregnancy is associated with adverse fetal outcomes, including microcephaly, growth restriction, and fetal demise. Type I interferons (IFNs) are essential for host resistance against ZIKV, and IFN-α/β receptor (IFNAR)-deficient mice are highly susceptible to ZIKV infection. Severe fetal growth restriction with placental damage and fetal resorption is observed after ZIKV infection of type I IFN receptor knockout (Ifnar1-/-) dams mated with wild-type sires, resulting in fetuses with functional type I IFN signaling...
January 5, 2018: Science Immunology
https://www.readbyqxmd.com/read/29288874/modeling-spike-wave-discharges-by-a-complex-network-of-neuronal-oscillators
#8
Tatiana M Medvedeva, Marina V Sysoeva, Gilles van Luijtelaar, Ilya V Sysoev
PURPOSE: The organization of neural networks and the mechanisms, which generate the highly stereotypical for absence epilepsy spike-wave discharges (SWDs) is heavily debated. Here we describe such a model which can both reproduce the characteristics of SWDs and dynamics of coupling between brain regions, relying mainly on properties of hierarchically organized networks of a large number of neuronal oscillators. MODEL: We used a two level mesoscale model. The first level consists of three structures: the nervus trigeminus serving as an input, the thalamus and the somatosensory cortex; the second level of a group of nearby situated neurons belonging to one of three modeled structures...
December 13, 2017: Neural Networks: the Official Journal of the International Neural Network Society
https://www.readbyqxmd.com/read/29287852/low-set-ears-and-associated-anomalies-in-human-foetuses
#9
Alfredo Nuñez-Castruita, Norberto López-Serna
OBJECTIVES: To determine the prevalence of low-set ears (LSE) in a group of human foetuses, to analyse the associated anomalies, and to review the development mechanisms possibly involved. METHODS: A total of 1759 human foetuses from spontaneous abortion were evaluated. Foetuses were obtained from the Foetuses and Embryos Collection of the Embryology Department of the Faculty of Medicine of the Autonomous University of Nuevo León. The Ethics Committee gave its approval for this study (EH-230-16)...
January 2018: International Journal of Pediatric Otorhinolaryngology
https://www.readbyqxmd.com/read/29282736/clinical-pitfalls-in-misoprostol-based-medical-management-of-first-trimester-induced-and-presumed-spontaneous-abortion
#10
Joseph R Wax, Kelley Conroy, Michael G Pinette, Christian Litton, Angelina Cartin
When administered inappropriately, first-trimester misoprostol management of induced or spontaneous abortion can result in loss or damage of a continuing pregnancy. Despite these serious consequences, such misoprostol exposures continue to occur. Unfortunately, contributing factors and preventive measures receive little attention. We describe the cases of 4 women in whom misoprostol was inappropriately administered during management of induced and presumed spontaneous abortion. In each case, careful adherence to published clinical guidance could have avoided the exposures...
December 28, 2017: Journal of Clinical Ultrasound: JCU
https://www.readbyqxmd.com/read/29282226/maternal-and-fetal-outcomes-of-pregnancies-in-women-with-atypical-hemolytic-uremic-syndrome
#11
Martina Gaggl, Christof Aigner, Dorottya Csuka, Ágnes Szilágyi, Zoltán Prohászka, Renate Kain, Natalja Haninger, Maarten Knechtelsdorfer, Raute Sunder-Plassmann, Gere Sunder-Plassmann, Alice Schmidt
Atypical HUS (aHUS) is a disorder most commonly caused by inherited defects of the alternative pathway of complement, or the proteins that regulate this pathway, and life-threatening episodes of aHUS can be provoked by pregnancy. We retrospectively and prospectively investigated 27 maternal and fetal pregnancy outcomes in 14 women with aHUS from the Vienna Thrombotic Microangiopathy Cohort. Seven pregnancies (26%) were complicated by pregnancy-associated aHUS (p-aHUS), of which three appeared to be provoked by infection, bleeding, and curettage, and three individuals were considered to have preeclampsia/HELLP syndrome before the definitive diagnosis of p-aHUS was made...
December 27, 2017: Journal of the American Society of Nephrology: JASN
https://www.readbyqxmd.com/read/29277063/effect-of-the-2015-nepal-earthquakes-on-symptoms-of-common-mental-disorders-among-women-who-are-pregnant
#12
Goma Kumari Khatri, Thach Duc Tran, Sushil Baral, Jane Fisher
BACKGROUND: Antenatal mental health problems are of concern globally not only because of the burden and limits to participation experienced by women but also because of risks for foetal neurocognitive development and adverse birth outcomes. The aim was to describe the indicative prevalence of and risk and protective factors for clinically-significant symptoms of antenatal common mental disorders (CMDs) among women who experienced the 2015 Nepal earthquakes during pregnancy. METHODS: A population-based cross-sectional study in Bhaktapur, one of 14 districts highly affected by the 2015 Nepal earthquakes...
December 9, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/29276412/association-between-coffee-or-caffeine-consumption-and-fecundity-and-fertility-a-systematic-review-and-dose-response-meta-analysis
#13
REVIEW
Julie Lyngsø, Cecilia Høst Ramlau-Hansen, Bjørn Bay, Hans Jakob Ingerslev, Adam Hulman, Ulrik Schiøler Kesmodel
Objective: The aim was to investigate whether coffee or caffeine consumption is associated with reproductive endpoints among women with natural fertility (ie, time to pregnancy [TTP] and spontaneous abortion [SAB]) and among women in fertility treatment (ie, clinical pregnancy rate or live birth rate). Design: This study was a systematic review and dose-response meta-analysis including data from case-control and cohort studies. Methods: An extensive literature search was conducted in MEDLINE and Embase, with no time and language restrictions...
2017: Clinical Epidemiology
https://www.readbyqxmd.com/read/29260525/-the-association-between-the-polymorphisms-of-mirna-biogenesis-related-genes-dicer-drosha-and-ran-and-unexplained-recurrent-spontaneous-abortion-in-chinese-women
#14
Mei Fu, Wen-Ming Xu, Tai-Zhou Qin, Ke-Hui Xu
OBJECTIVE: To explore the association between polymorphisms of miRNA biogenesis related gene DICER,DROSHA,RAN and unexplained recurrent spontaneous abortion (URSA) in Chinese women. METHODS: We recruited 217 patients with URSA (URSA group) and 390 healthy controls who were fertile women with history of more than one successful pregnancy outcome (control group) from June 2013 to December 2015 in the West China Second University Hospital of Sichuan University. The control group was recruited from regular physical examination and prepregnancy check for women of childbearing age during the same period...
November 2017: Sichuan da Xue Xue Bao. Yi Xue Ban, Journal of Sichuan University. Medical Science Edition
https://www.readbyqxmd.com/read/29243795/the-effect-on-clinical-results-of-adding-recombinant-lh-in-late-phase-of-ovarian-stimulation-of-patients-with-repeated-implantation-failure-a-pilot-study
#15
A Rahman, D Francomano, F Sagnella, F Lisi, C Manna
OBJECTIVE: To evaluate the efficacy of recombinant LH (r-LH) addition in the late phase of ovarian stimulation in patients with repeated implantation failure (RIF). PATIENTS AND METHODS: 66 infertile couples undergoing ICSI treatment due to male factor were allocated to group A (33) and to group B (33). Group A (29 subjects) received recombinant FSH (r-FSH) supplemented by r-LH in the late follicular phase starting the same day of GnRH-antagonist (GnRH-ant) administration, and group B (32 subjects) received r-FSH alone...
December 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/29241391/analysis-of-cystic-hygroma-diagnosed-in-the-prenatal-period-5-years-experience-at-a-tertiary-hospital-in-southeastern-turkey
#16
Hüseyin Çağlayan Özcan, Mete Gurol Uğur, Özcan Balat, Seyhun Sucu, Neslihan Bayramoğlu Tepe, Ebru Öztürk, Özge Kömürcü Karuserci, Tanyeli Güneyligil Kazaz
PURPOSE: Our aim was to evaluate the association of cystic hygroma (CH) with fetal malformations and also to investigate the outcome of fetuses with CH diagnosed in the prenatal period. METHODS: We divided the CH patients into two main groups as isolated CH or CH associated with the congenital structural abnormality (CSA) by measuring the thickness of CH and showing other fetal abnormalities. Pregnancy outcomes were recorded as spontaneous abortion, elective termination, intrauterine death, live birth, postnatal death, and lost to follow-up...
December 27, 2017: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/29238894/a-nonparametric-maximum-likelihood-approach-for-survival-data-with-observed-cured-subjects-left-truncation-and-right-censoring
#17
Jue Hou, Christina D Chambers, Ronghui Xu
We consider observational studies in pregnancy where the outcome of interest is spontaneous abortion (SAB). This at first sight is a binary 'yes' or 'no' variable, albeit there is left truncation as well as right-censoring in the data. Women who do not experience SAB by gestational week 20 are 'cured' from SAB by definition, that is, they are no longer at risk. Our data is different from the common cure data in the literature, where the cured subjects are always right-censored and not actually observed to be cured...
December 13, 2017: Lifetime Data Analysis
https://www.readbyqxmd.com/read/29238403/mosaicism-for-structural-non-centromeric-autosomal-rearrangement-in-prenatal-diagnoses-evidence-for-sex-specific-selection-against-chromosomal-abnormalities
#18
REVIEW
Natalia V Kovaleva, Philip D Cotter
Background: Mosaicism for chromosome rearrangements is common in preimplantation diagnoses, yet is rare in prenatal diagnoses as well as in other groups of patients referred to cytogenetic testing. Consequently, there is a lack of detailed studies on this kind of mosaicism in all groups of patients. Previous reports have identified a deficit of males among asymptomatic carriers of N/unbalanced Rea. Three mechanisms were proposed for explaining this phenomenon, including a high instability in the early female embryonic development, a male-specific selection against abnormal cells in the early embryo development, or a high intrauterine lethality of male carriers...
2017: Molecular Cytogenetics
https://www.readbyqxmd.com/read/29237347/pregnancy-history-influences-the-level-of-autophagy-in-peripheral-blood-mononuclear-cells-from-pregnant-women
#19
Aswathi Jayaram, Tomi Kanninen, Giovanni Sisti, Steven R Inglis, Nurah Morgan, Steven S Witkin
OBJECTIVE: Maternal immune responses are altered during pregnancy and differ between nulliparous and multiparous women. The influence of a prior gestation on autophagy in peripheral blood mononuclear cells (PBMCs) from pregnant women has not been determined and is the subject of this investigation. METHODS: Peripheral blood mononuclear cells were isolated from 212 pregnant women and immediately lysed in the presence of protease inhibitors, and the extent of autophagy was determined by quantitation of the concentration of p62 (sequestosome-1) in the lysates by enzyme-linked immunosorbent assay (ELISA)...
January 1, 2017: Reproductive Sciences
https://www.readbyqxmd.com/read/29222350/leflunomide-use-during-pregnancy-and-the-risk-of-adverse-pregnancy-outcomes
#20
Anick Bérard, Jin-Ping Zhao, Irene Shui, Susan Colilla
OBJECTIVES: Leflunomide is known to be embryotoxic and teratogenic in rodents. However, there is less evidence in humans. We quantified the risk of major congenital malformation (MCM), prematurity, low birth weight (LBW) and spontaneous abortion associated with leflunomide exposure during pregnancy in humans. METHODS: From a cohort of 289 688 pregnancies in Montreal, Quebec, Canada, from 1998 to 2015, first-trimester leflunomide exposure and other antirheumatic drug exposures were studied for their association with MCM and spontaneous abortions...
December 8, 2017: Annals of the Rheumatic Diseases
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