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Spontaneous Abortion

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https://www.readbyqxmd.com/read/28629238/us-trends-in-abortion-and-preterm-birth
#1
Elena Rita Magro Malosso, Gabriele Saccone, Biagio Simonetti, Massimo Squillante, Vincenzo Berghella
BACKGROUND: A recent large meta-analysis concluded that prior surgical abortion was an independent risk factor for spontaneous preterm birth (PTB), while they found no significant correlation between PTB and medical abortion. OBJECTIVE: To evaluate the potential impact of changes in US abortion rates and practices on US incidence of PTB rate. STUDY DESIGN: This was an epidemiologic analysis of legal abortion and PTB data in the USA from 2003-2012...
June 19, 2017: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/28627774/decreased-expression-of-wnt2-in-villi-of-unexplained-recurrent-spontaneous-abortion-patients-may-cause-trophoblast-cell-dysfunction-via-downregulated-wnt-%C3%AE-catenin-signaling-pathway
#2
Ning Li, Shuhong Li, Yanwei Wang, Jiahui Wang, Kai Wang, Xin Liu, Yan Li, Juan Liu
WNT2 has been reported to be important for placental development, especially for the proper vascularization of the placenta. However, its precise role in first-trimester trophoblast cells is still unknown. WNT2 expression in the villous tissues of unexplained recurrent spontaneous abortion (URSA) patients was compared with that of healthy women by Western blot. The function of WNT2 in HTR-8/SVneo trophoblast cells was evaluated by altering the cellular WNT2 level through overexpression and shRNA knockdown. The molecular mechanism of the effect of WNT2 on trophoblast cells was investigated...
June 19, 2017: Cell Biology International
https://www.readbyqxmd.com/read/28627638/meiotic-defects-and-decreased-expression-of-genes-located-around-the-chromosomal-breakpoint-in-the-testis-of-a-patient-with-a-novel-46-x-t-y-1-p11-3-p31-translocation
#3
Guangyuan Li, Furhan Iqbal, Liu Wang, Zhipeng Xu, Xiaoyan Che, Wen Yu, Liang Shi, Tonghang Guo, Guixiang Zhou, Xiaohua Jiang, Huan Zhang, Yuanwei Zhang, Dexin Yu
Balanced translocations are known to be associated with infertility, spontaneous abortions and birth defects in mammals. Spermatocyte spreading and immunostaining were applied to detect meiotic prophase I progression, homologous chromosome pairing, synapsis and recombination in an azoospermic reciprocal translocation 46,X,t(Y;1)(p11.3;p31) carrier. Histological examination of testicular sections revealed a severely reduced number of germ cells with no spermatids or sperm in the carrier. A significant reduction in XY recombination was observed in the patient...
June 14, 2017: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/28620370/environmental-t4-family-bacteriophages-evolve-to-escape-abortive-infection-via-multiple-routes-in-a-bacterial-host-employing-altruistic-suicide-through-type-iii-toxin-antitoxin-systems
#4
Bihe Chen, Chidiebere Akusobi, Xinzhe Fang, George P C Salmond
Abortive infection is an anti-phage mechanism employed by a bacterium to initiate its own death upon phage infection. This reduces, or eliminates, production of viral progeny and protects clonal siblings in the bacterial population by an act akin to an "altruistic suicide." Abortive infection can be mediated by a Type III toxin-antitoxin system called ToxINPa consisting of an endoribonuclease toxin and RNA antitoxin. ToxINPa is a heterohexameric quaternary complex in which pseudoknotted RNA inhibits the toxicity of the toxin until infection by certain phages causes destabilization of ToxINPa, leading to bacteriostasis and, eventually, lethality...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28617148/outcomes-of-ivf-cycles-coupled-with-pgs-by-acgh-of-embryos-from-donor-and-autologous-oocytes-transferred-after-vitrification-to-women-of-advanced-maternal-age
#5
Elena M Fedorova, Svetlana A Shlykova, Ksenia V Shunkina, Olga G Zaitceva, Elena N Lapina, Taras V Yanchuk, Alla S Kalugina
It is well documented that aneuploidy rate in preimplantation embryos increases with the mother's age, and at the same time the number of oocytes diminishes. Consequently, for patients of advanced maternal age two options are available to overcome these limitations: use of oocytes from young donors, or use of own oocytes coupled with preimplantation genetic screening (PGS) for 24 chromosomes. However, it is not clear which strategy might be more effective. The aim of this retrospective study was to evaluate outcomes of IVF cycles coupled with transfer of vitrified embryos from donor or autologous oocytes, both with or without PGS...
June 15, 2017: Gynecological Endocrinology
https://www.readbyqxmd.com/read/28616412/assessing-the-presence-of-chlamydia-trachomatis-genome-in-pregnant-women-with-spontaneous-abortion-using-polymerase-chain-reaction-method-in-yasuj-first-report-from-southwest-of-iran
#6
Alborz Jahangiri Sisakht, Navid Omidifar, Nahid Mohamadkhani, Maryam Karimpoorfard, Mohammad Kargar, Mansoureh Shokripour
CONTEXT: Chlamydia trachomatis is one of the most prevalent factors of sexually transmitted diseases worldwide, which causes abortion, premature rupture of membrane, uterine cervicitis, pelvic inflammatory diseases, and ectopic pregnancy. AIMS: The aim of this study was to investigate the presence of C. trachomatis genome in pregnant women with abortion in Yasuj, Iran. SETTINGS AND DESIGN: This is a descriptive-analytical study in Shahid Mofateh Gyneco-obstetrics clinic and Emam sajjad Hospital...
2017: Journal of Education and Health Promotion
https://www.readbyqxmd.com/read/28609762/increased-toll-like-receptor-myeloid-differentiation-factor-88-expression-at-the-maternal-fetal-interface-is-associated-with-spontaneous-abortion
#7
Mengzhou He, Yuan Zhou, Min Jiang, Fanfan Li, Meitao Yang, Yao Fan, Dongrui Deng
AIMS: Toll-like receptors (TLRs) form a group of pattern recognition receptors that play a major role in maintaining innate host immunity. Myeloid differentiation factor 88 (MyD88) is an adaptor molecule that is essential for signaling via the TLR family. To analyze the mechanism of the imbalance in the innate immune system mediated by TLRs-MyD88 in spontaneous abortion, we detected the expression of TLR-2, TLR-4, TLR-7, and MyD88 in placentae and deciduas. METHODS: The expression of TLR-2, TLR-4, TLR-7, and MyD88 in the placentae and deciduas of abortion-prone mice (n = 10) and normal pregnant mice (n = 10) were analyzed by immunochemistry, western blot, and real-time polymerase chain reaction...
June 14, 2017: Gynecologic and Obstetric Investigation
https://www.readbyqxmd.com/read/28602043/efficacy-of-first-trimester-ultrasound-parameters-for-prediction-of-early-spontaneous-abortion
#8
Mamta Rath Datta, Ankush Raut
OBJECTIVE: To assess first-trimester ultrasound measurements for the prediction of early spontaneous abortion. METHODS: In a prospective observational study in Jamshedpur, India, women with a singleton pregnancy of 42-76 days were enrolled between November 2014 and April 2016. Inclusion criteria were spontaneous conception, embryonic cardiac activity, and regular menstrual cycle. Fetal crown-to-rump length (CRL), gestational sac diameter (GSD), yolk sac diameter (YSD), and fetal heart rate (FHR) were measured by transvaginal ultrasonography...
June 11, 2017: International Journal of Gynaecology and Obstetrics
https://www.readbyqxmd.com/read/28600063/molecular-cytogenetic-characterization-of-mosaicism-for-a-small-supernumerary-marker-chromosome-derived-from-chromosome-7-in-the-male-partner-of-a-phenotypically-normal-couple-with-repeated-spontaneous-abortions
#9
Chih-Ping Chen, Ming Chen, Yuh-Ming Hwu, Shun-Ping Chang, Shin-Wen Chen, Shih-Ting Lai, Chen-Chi Lee, Wayseen Wang
No abstract text is available yet for this article.
June 2017: Taiwanese Journal of Obstetrics & Gynecology
https://www.readbyqxmd.com/read/28600033/evaluation-of-hla-g-14-bp-ins-del-and%C3%A2-3142g-c-polymorphisms-with-susceptibility-to-recurrent-spontaneous-abortion
#10
Mohammad Hashemi, Mojgan Mokhtari, Safura Khazaeian, Gholamreza Bahari, Maryam Rezaei, Alireza Nakhaee, Mohsen Taheri
OBJECTIVE: HLA-G is critically important for successful implantation during pregnancy. Increasing evidence supposed that HLA-G plays a key role in tolerance of the semi-allogeneic graft in pregnancy by inhibiting the cytotoxic functions of T and NK cells. The present study aimed to evaluate the impact of HLA-G rs1063320 (+3142G>C) and 14-bp insertion (ins)/deletion (del) polymorphisms on recurrent spontaneous abortion (RSA). MATERIALS AND METHODS: Genomic DNA from 93 RSA patients and 93 normal fertile women was isolated using the salting out method...
June 2017: Taiwanese Journal of Obstetrics & Gynecology
https://www.readbyqxmd.com/read/28599391/association-between-genital-mycoplasmas-acute-chorioamnionitis-and-fetal-pneumonia-in-spontaneous-abortions
#11
Maria Agnese Latino, Giovanni Botta, Claudia Badino, Daniela De Maria, Annalisa Petrozziello, Alessandra Sensini, Christian Leli
AIM: Ureaplasma parvum, Ureaplasma urealyticum and Mycoplasma hominis are also known as genital mycoplasmas. Acute chorioamnionitis is an inflammation of the placenta associated with miscarriage. We retrospectively evaluated a possible association between genital mycoplasmas detection, acute chorioamnionitis and fetal pneumonia from second and third trimester spontaneous abortions. METHODS: One hundred and thirty placenta and fetal lung samples were evaluated for histological examination...
May 25, 2017: Journal of Perinatal Medicine
https://www.readbyqxmd.com/read/28595591/effect-of-race-and-ethnicity-on-utilization-and-outcomes-of-assisted-reproductive-technology-in-the-usa
#12
Alice J Shapiro, Sarah K Darmon, David H Barad, David F Albertini, Norbert Gleicher, Vitaly A Kushnir
BACKGROUND: The purpose of this study was to determine the utilization and live birth rates of assisted reproductive technology (ART) modalities among various racial and ethnic groups in recent years. METHODS: We reviewed ART data reported to the Society for Assisted Reproductive Technologies Clinic Outcome Reporting System (SART CORS) for autologous ART and third-party ART (3ART) cycles which involved donor oocytes, sperm, embryos and gestational carrier, performed in the U...
June 8, 2017: Reproductive Biology and Endocrinology: RB&E
https://www.readbyqxmd.com/read/28588636/a-case-of-spontaneous-abortion-related-to-ovarian-endometriosis-in-a-golden-retriever-dog
#13
M A Demirel
This report describes a case of spontaneous abortion in a 4-year-old Golden Retriever dog with ovarian endometriosis. Clinical findings indicated that there was not any senstivity in the abdomen and the viability parameters were within the reference values. On vaginal examination, serosanguineous discharge was determined. Ultrasonographic examination revealed that no fetus was observed in cornu uteri and an hypoechoic cystic structure, measuring 3.2 × 3.4 cm was found behind the left kidney. Ovarian cyst was suspected, and then ovariohysterectomy was performed...
2017: Iranian journal of veterinary research
https://www.readbyqxmd.com/read/28587344/acquired-uterine-arteriovenous-fistula-due-to-a-previous-cornual-pregnancy-with-placenta-accreta-a-case-report
#14
Dongdong Guan, Jie Wang, Liju Zong, Shan Li, You-Zhong Zhang
The present report describes a case of an acquired uterine arteriovenous fistula, which, following surgery and postoperative pathological analysis, was confirmed as a previous cornual pregnancy with placenta accreta. The patient was a 37-year-old woman (gravida 3; para 2) who had previously delivered two children via cesarean section (in 2004 and 2010, respectively) and also had a spontaneous abortion (2008). She had experienced continuous menstrual bleeding for ~20 days and had a history of prolonged (~30 days) vaginal bleeding 13 months earlier...
June 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28584200/efficacy-of-different-treatment-regimens-for-antiphospholipid-syndrome-related-recurrent-spontaneous-abortion
#15
Sheng-Long Ye, Xun-Ke Gu, Li-Yuan Tao, Ji-Mei Cong, Yong-Qing Wang
BACKGROUND: Antiphospholipid syndrome (APS)-related immune factors are considered as an important cause of recurrent spontaneous abortion (RSA). Anticoagulant and anti-inflammatory treatments are believed to effectively improve adverse pregnancy outcomes by affecting the abnormal autoimmune response of the maternal-fetal interface. The aim of this study was to observe the clinical characteristics and treatment outcomes of anticoagulant regimens and anti-inflammatory plus anticoagulation regimens for APS-related RSA...
June 20, 2017: Chinese Medical Journal
https://www.readbyqxmd.com/read/28583873/a-trade-off-between-catalytic-activity-and-protein-stability-determines-the-clinical-manifestations-of-glucose-6-phosphate-dehydrogenase-g6pd-deficiency
#16
Usa Boonyuen, Kamonwan Chamchoy, Thitiluck Swangsri, Thanyaphorn Junkree, Nicholas P J Day, Nicholas J White, Mallika Imwong
Glucose-6-phosphate dehydrogenase (G6PD) deficiency is the most common polymorphism and enzymopathy in humans, affecting approximately 400 million people worldwide. It is responsible for various clinical manifestations, including favism, hemolytic anemia, chronic non-spherocytic hemolytic anemia, spontaneous abortion, and neonatal hyperbilirubinemia. Understanding the molecular mechanisms underlying the severity of G6PD deficiency is of great importance but that of many G6PD variants are still unknown. In this study, we report the construction, expression, purification, and biochemical characterization in terms of kinetic properties and stability of five clinical G6PD variants-G6PD Bangkok, G6PD Bangkok noi, G6PD Songklanagarind, G6PD Canton+Bangkok noi, and G6PD Union+Viangchan...
June 3, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28578675/a-case-report-of-bicornis-bicollis-uterus-with-unilateral-cervical-atresia-an-unusual-aetiology-of-chronic-debilitating-pelvic-pain-in-a-cameroonian-teenager
#17
Julius Sama Dohbit, Esther Meka, Joel Noutakdie Tochie, Igor Kamla, Darolles Mwadjie, Pascal Foumane
BACKGROUND: Congenital uterine anomalies like bicornis or bicornuate uterus are relatively rare in sub-Saharan Africa. They are associated with an increased rate of spontaneous abortion, preterm delivery, and infertility. The occurrence of bicornis bicollis uterus with unilateral cervical atresia is exceptional and its management is controversial. We hereby report a rare cause of chronic pelvic pain in a Cameroonian teenager due to unilateral obstructive hematometra and hematosalpinx in the non-communicating horn of a bicornis bicollis uterus...
June 2, 2017: BMC Women's Health
https://www.readbyqxmd.com/read/28578152/examining-intendedness-among-pregnancies-ending-in-spontaneous-abortion
#18
Rachel Flink-Bochacki, Leslie A Meyn, Beatrice A Chen, Sharon L Achilles, Judy C Chang, Sonya Borrero
OBJECTIVES: Spontaneous abortion (SAB) affects over 1 million US women each year, yet little is known about the intendedness of these pregnancies. We examined prevalence and correlates of unintended and unwanted pregnancies ending in SAB. STUDY DESIGN: We used nationally-representative cross-sectional data of US women aged 15-44 from the 2011-2013 National Survey of Family Growth to examine pregnancies ending in SAB. We used modified Poisson regression models to evaluate associations between demographic and pregnancy characteristics with unintended and unwanted pregnancy...
May 31, 2017: Contraception
https://www.readbyqxmd.com/read/28571631/maternal-and-fetal-outcomes-of-anticoagulation-in-pregnant-women-with%C3%A2-mechanical-heart%C3%A2-valves
#19
Zachary L Steinberg, Clara P Dominguez-Islas, Catherine M Otto, Karen K Stout, Eric V Krieger
BACKGROUND: Anticoagulation for mechanical heart valves during pregnancy is essential to prevent thromboembolic events. Each regimen has drawbacks with regard to maternal or fetal risk. OBJECTIVES: This meta-analysis sought to estimate and compare the risk of adverse maternal and fetal outcomes in pregnant women with mechanical heart valves who received different methods of anticoagulation. METHODS: Studies were identified using a Medline search including all publications up to June 5, 2016...
June 6, 2017: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/28567059/intraplacental-choriocarcinoma-rare-or-underdiagnosed-report-of-2-cases-diagnosed-after-an-incomplete-miscarriage-and-a-preterm-spontaneous-vaginal-delivery
#20
Rita Ferraz Caldas, Paula Oliveira, Cátia Rodrigues, Inês Reis, Horácio Scigliano, Rosete Nogueira, Célia Araújo, Soledade Ferreira
Intraplacental choriocarcinoma is a rare malignant tumor diagnosed after an abortion, an ectopic pregnancy, or a term or preterm pregnancy or following the diagnosis of a hydatidiform mole. During pregnancy, it may be more common than reported, as most patients are asymptomatic and placental choriocarcinomas are usually inconspicuous macroscopically and are often mistaken for an infarct. Based upon a case study methodology, we describe 2 cases of intraplacental choriocarcinoma: the first case was identified in the product of a uterine curettage following an incomplete miscarriage and the second in one of the placentas of a bichorionic twin pregnancy...
2017: Case Reports in Medicine
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