keyword
MENU ▼
Read by QxMD icon Read
search

α2 receptor

keyword
https://www.readbyqxmd.com/read/29146976/association-of-a-variant-in-the-gene-encoding-for-erv1-chemr23-with-reduced-inflammation-in-visceral-adipose-tissue-from-morbidly-obese-individuals
#1
Cristina López-Vicario, Bibiana Rius, José Alcaraz-Quiles, Ana González-Périz, Ana Isabel Martínez-Puchol, Mireia Casulleras, Marta Duran-Güell, Ainitze Ibarzabal, Ricard Corcelles, Andrés Laguna-Fernández, Magnus Back, Esther Titos, Joan Clària
Obesity comorbidities are closely associated with chronic low-grade adipose tissue inflammation. A number of SNPs associated with inflammation has been identified, underscoring the impact of genetic determinants on this process. Here, we screened SNPs in genes with pro-inflammatory (IL-1β, IL-6, STAT3 and JAK2), anti-inflammatory (IL-10 and SOCS3) and pro-resolving (ERV1/ChemR23) properties in 101 obese and 99 non-obese individuals. Among the SNPs analyzed, we identified that individuals carrying a C allele in the rs1878022 polymorphism of the ERV1/ChemR23 gene, which encodes for the receptor of the pro-resolving mediator RvE1, had increased ERV1/ChemR23 protein expression and reduced levels of the inflammatory cytokine IL-6 in adipose tissue...
November 16, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29146239/innately-activated-tlr4-signal-in-the-nucleus-accumbens-is-sustained-by-crf-amplification-loop-and-regulates-impulsivity
#2
Irina Balan, Kaitlin T Warnock, Adam Puche, Marjorie C Gondre-Lewis, Laure Aurelian
Cognitive impulsivity is a heritable trait believed to represent the behavior that defines the volition to initiate alcohol drinking. We have previously shown that a neuronal Toll-like receptor 4 (TLR4) signal located in the central amygdala (CeA) and ventral tegmental area (VTA) controls the initiation of binge drinking in alcohol-preferring P rats, and TLR4 expression is upregulated by alcohol-induced corticotropin-releasing factor (CRF) at these sites. However, the function of the TLR4 signal in the nucleus accumbens shell (NAc-shell), a site implicated in the control of reward, drug-seeking behavior and impulsivity and the contribution of other signal-associated genes, are still poorly understood...
November 13, 2017: Brain, Behavior, and Immunity
https://www.readbyqxmd.com/read/29146181/proximity-labeling-of-cis-ligands-of-cd22-siglec-2-reveals-stepwise-%C3%AE-2-6-sialic-acid-dependent-and-independent-interactions
#3
Amin Alborzian Deh Sheikh, Chizuru Akatsu, Akihiro Imamura, Hajjaj H M Abdu-Allah, Hiromu Takematsu, Hiromune Ando, Hideharu Ishida, Takeshi Tsubata
Lectins expressed on the cell surface are often bound and regulated by the membrane molecules containing the glycan ligands on the same cell (cis-ligands). However, molecular nature and function of cis-ligands are generally poorly understood partly because of weak interaction between lectins and glycan ligands. Cis-ligands are most extensively studied in CD22 (also known as Siglec-2), an inhibitory B lymphocyte receptor specifically recognizing α2,6 sialic acids. CD22, CD45 and IgM are suggested to be ligands of CD22...
November 13, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29140707/grapefruit-flavonoid-naringenin-regulates-the-expression-of-lxr%C3%AE-in-thp-1-macrophages-by-modulating-amp-activated-protein-kinase
#4
Javier Saenz, Consuelo Santa-María, Maria Edith Reyes-Quiroz, Isabel Geniz, Juan Jiménez, Francisco Sobrino, Gonzalo Alba
The present work investigates the modulation of grapefruit flavonoid naringenin over Liver X Receptor alpha (LXRα) and its target genes in THP-1 macrophages, focusing on AMP-activated protein kinase (AMPK) implication. Naringenin induced LXRα at mRNA and protein levels besides influencing the expression of LXRα target genes ABCA1, ABCG1 (ATP-binding cassette A1 and G1), and SREBP1c (sterol response element binding protein 1c) in THP-1 macrophages. The increased LXRα mRNA and protein expression was reverted when AMPK was inhibited by its chemical inhibitor, compound C or by transfection with AMPK α1 and α2 siRNA...
November 15, 2017: Molecular Pharmaceutics
https://www.readbyqxmd.com/read/29138828/identification-of-risk-genes-associated-with-myocardial-infarction-based-on-the-recursive-feature-elimination-algorithm-and-support-vector-machine-classifier
#5
Xiaoqiang Yang
The aim of the present study was to identify risk genes in myocardial infarction. Microarray data GSE34198, containing data from the peripheral blood of 49 myocardial infarction samples and 48 corresponding control samples, were downloaded from the Gene Expression Omnibus database to screen the differentially expressed genes (DEGs). The DEGs were used to construct a protein‑protein interaction (PPI) network of patient samples, from which the feature genes were identified using the neighboring score method...
November 14, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29138105/adrenergic-receptor-agonists-modulation-of-dopaminergic-and-non-dopaminergic-neurons-in-the-ventral-tegmental-area
#6
Kamil Pradel, Tomasz Blasiak, Wojciech B Solecki
The ventral tegmental area (VTA) neuronal population consists of dopaminergic (DAergic) and non-DAergic neurons (mainly GABAergic), the activity of which is intertwined with VTA behavioural functions. Both DAergic and GABAergic neurons in the VTA have been shown to express adrenergic receptors (ARs) and respond to AR stimulation. The aim of the present study was to demonstrate the effects of selective AR agonists on DAergic and non-DAergic neuronal activity in the central and lateral parts of the VTA using in vivo electrophysiological recording combined with microiontophoretic drug application in anaesthetized rats...
November 11, 2017: Neuroscience
https://www.readbyqxmd.com/read/29133347/analysis-of-the-human-mucosal-response-to-cholera-reveals-sustained-activation-of-innate-immune-signaling-pathways
#7
Daniel L Bourque, Taufiqur Rahman Bhuiyan, Diane P Genereux, Rasheduzzaman Rashu, Crystal N Ellis, Fahima Chowdhury, Ashraful I Khan, Nur Haq Alam, Anik Paul Lazina Hossain, Leslie M Mayo-Smith, Richelle C Charles, Ana A Weil, Regina C LaRocque, Stephen B Calderwood, Edward T Ryan, Elinor K Karlsson, Firdausi Qadri, Jason B Harris
To better understand the innate immune response to Vibrio cholerae infection, we tracked gene expression in the duodenal mucosa of eleven Bangladeshi adults with cholera, using biopsies obtained immediately after rehydration and at 30 and 180 days later. We identified differentially expressed genes and performed an analysis to predict differentially regulated pathways and upstream regulators. During acute cholera, there was a broad increase in the expression of genes associated with innate immunity, including activation of the NF-κB, MAPK, and TLR-mediated signaling pathways, which unexpectedly persisted even 30 days after infection...
November 13, 2017: Infection and Immunity
https://www.readbyqxmd.com/read/29118117/a-y161f-hemagglutinin-substitution-increases-thermostability-and-improves-yields-of-2009-h1n1-influenza-a-virus-in-cells
#8
Feng Wen, Lei Li, Nan Zhao, Meng-Jung Chiang, Hang Xie, Jim Cooley, Richard Webby, Peng George Wang, Xiu-Feng Wan
Vaccination is the primary strategy for influenza prevention and control. Yet egg-based vaccines, the predominant production platform, have several disadvantages including the emergence of viral antigenic variants that can be induced during egg passage. These limitations have prompted development of cell-based vaccines which themselves are not without issue. Most importantly, vaccine seed viruses often do not grow efficiently in mammalian cell lines. Here we aimed to identify novel high-yield signatures for influenza viruses in continuous Madin-Darby canine kidney (MDCK) and Vero cells...
November 8, 2017: Journal of Virology
https://www.readbyqxmd.com/read/29118027/heterogeneity-of-signal-transduction-by-na-k-atpase-%C3%AE-isoforms-role-of-src-interaction
#9
Hui Yu, Xiaoyu Cui, Jue Zhang, Joe X Xie, Moumita Banerjee, Sandrine V Pierre, Zijian Xie
Of the four Na/K-ATPase α isoforms, the ubiquitous α1 Na/K-ATPase possesses both ion transport and Src-dependent signaling functions. Mechanistically, we have identified two putative pairs of domain interactions between α1 Na/K-ATPase and Src that are critical for α1 signaling. Our subsequent report that α2 Na/K-ATPase lacks these putative Src-binding sites and fails to carry on Src-dependent signaling further supported our proposed model of direct interaction between α1 Na/K-ATPase and Src, but fell short of providing evidence for a causative role...
November 8, 2017: American Journal of Physiology. Cell Physiology
https://www.readbyqxmd.com/read/29113928/cerebral-malaria-causes-enduring-behavioral-and-molecular-changes-in-mice-brain-without-causing-gross-histopathological-damage
#10
Thaíze Lopes de Souza, Ana Claudia Beck Grauncke, Leandro Rodrigo Ribeiro, Fernanda Kulinski Mello, Sara Marchesan Oliveira, Fátima Brant, Fabiana S Machado, Mauro Schneider Oliveira
Malaria, parasitic disease considered a major health public problem, is caused by Plasmodium protozoan genus and transmitted by the bite of infected female Anopheles mosquito genus. Cerebral malaria (CM) is the most severe presentation of malaria, caused by P. falciparum and responsible for high mortality and enduring development of cognitive deficits which may persist even after cure and cessation of therapy. In the present study we evaluated selected behavioral, neurochemical and neuropathologic parameters after rescue from experimental cerebral malaria caused by P...
November 4, 2017: Neuroscience
https://www.readbyqxmd.com/read/29111111/anti-aggregation-effect-of-aroxyalkyl-derivatives-of-2-methoxyphenylpiperazine-is-due-to-their-5-ht2a-and-%C3%AE-2-adrenoceptor-antagonistic-properties-a-comparison-with-ketanserin-sarpogrelate-prazosin-yohimbine-and-arc239
#11
Monika Kubacka, Grzegorz Kazek, Magdalena Kotańska, Barbara Filipek, Anna Maria Waszkielewicz, Szczepan Mogilski
Serotonin (5-HT) and adrenaline acting at platelet 5-HT2A-serotoninergic and α2-adrenergic receptors are involved in platelet aggregation. We have evaluated the antagonistic potency at 5-HT2A, α2A-, and α2B-adrenoceptors as well as an anti-aggregation effect of aroxyalkyl derivatives of 2-methoxyphenylpiperazine and compared them with ketanserin, sarpogrelate, prazosin, yohimbine and ARC239 (2-[2-[4-(o-methoxyphenyl)-piperazin-1-yl]-ethyl]-4,4-dimethyl-1,3-(2H,4H)-isoquinolindione). Functional bioassays at cells expressing human receptors, revealed studied compounds to be moderate antagonists of 5-HT2A and α2-adrenoceptors, with around 2-7 times stronger antagonistic effect at α2B subtype than α2A subtype...
October 27, 2017: European Journal of Pharmacology
https://www.readbyqxmd.com/read/29109059/loop-f-of-the-gabaa-receptor-alpha-subunit-governs-gaba-potency
#12
Adrienn Pálvölgyi, Krisztina Móricz, Ágnes Pataki, Balázs Mihalik, Gábor Gigler, Katalin Megyeri, Szabolcs Udvari, István Gacsályi, Ferenc A Antoni
Gamma-amino butyric acid (GABA) is an abundant neurotransmitter in the CNS. GABAergic interneurons orchestrate pyramidal neurons in the cerebral cortex, and thus control learning and memory. Ionotropic receptors for GABA (GABAAR) are heteropentameric complexes of α, β and γ integral membrane-protein subunits forming Cl(-) -channels operated by GABA, which are vital for brain function and are important drug targets. However, knowledge on how GABAAR bind GABA is controversial. Structural biology versus functional modelling combined with site-directed mutagenesis suggest markedly different roles for loop F of the extracellular domain of the α-subunit when complexed with GABA...
November 3, 2017: Neuropharmacology
https://www.readbyqxmd.com/read/29107054/selecting-the-correct-cellular-model-for-assessing-of-the-biological-response-of-collagen-based-biomaterials
#13
Natalia Davidenko, Samir Hamaia, Daniel V Bax, Jean-Daniel Malcor, Carlos F Schuster, Donald Gullberg, Richard W Farndale, Serena M Best, Ruth E Cameron
Accurate evaluation of the biological performance of biomaterials requires the correct assessment of their native-like cell ligation properties. However, cell attachment studies often overlook the details of the substrate-cell binding mechanisms, be they integrin-mediated or non-specific, and ignore the class- and species-specificities of the cell adhesion receptor involved. In this work we have used different collagen (Col) substrates (fibrillar collagens I, II and III and network-forming Col IV), containing different affinity cell-recognition motifs, to establish the influence of the receptor identity and species-specificity on collagen-cell interactive properties...
October 26, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/29103912/optimization-of-il13r%C3%AE-2-targeted-chimeric-antigen-receptor-t-cells-for-improved-anti-tumor-efficacy-against-glioblastoma
#14
Christine E Brown, Brenda Aguilar, Renate Starr, Xin Yang, Wen-Chung Chang, Lihong Weng, Brenda Chang, Aniee Sarkissian, Alfonso Brito, James F Sanchez, Julie R Ostberg, Massimo D'Apuzzo, Behnam Badie, Michael E Barish, Stephen J Forman
T cell immunotherapy is emerging as a powerful strategy to treat cancer and may improve outcomes for patients with glioblastoma (GBM). We have developed a chimeric antigen receptor (CAR) T cell immunotherapy targeting IL-13 receptor α2 (IL13Rα2) for the treatment of GBM. Here, we describe the optimization of IL13Rα2-targeted CAR T cells, including the design of a 4-1BB (CD137) co-stimulatory CAR (IL13BBζ) and a manufacturing platform using enriched central memory T cells. Utilizing orthotopic human GBM models with patient-derived tumor sphere lines in NSG mice, we found that IL13BBζ-CAR T cells improved anti-tumor activity and T cell persistence as compared to first-generation IL13ζ-CAR CD8(+) T cells that had shown evidence for bioactivity in patients...
October 5, 2017: Molecular Therapy: the Journal of the American Society of Gene Therapy
https://www.readbyqxmd.com/read/29102760/partial-inhibition-of-catecholamine-activity-and-enhanced-responsiveness-to-nmda-after-sustained-administration-of-vortioxetine
#15
Mohammad Ebrahimzadeh, Mostafa El Mansari, Pierre Blier
Vortioxetine is a multimodal drug that blocks serotonin (5-HT) reuptake and directly modulates 5-HT receptors. The effects of subacute and long-term administration of vortioxetine on various aspects of catecholamine and glutamate systems were investigated using single-unit extracellular recordings and microiontophoresis in the rat brain. The firing rate of dopamine (DA) neurons was significantly decreased (26%) after 14, but not 4 days of vortioxetine administration (vortioxetine-containing chow, 1.8 g/kg vortioxetine)...
November 13, 2017: Neuropharmacology
https://www.readbyqxmd.com/read/29102224/an-endogenous-tryptophan-photo-product-ficz-is-potentially-involved-in-photo-aging-by-reducing-tgf-%C3%AE-regulated-collagen-homeostasis
#16
Mika Murai, Gaku Tsuji, Akiko Hashimoto-Hachiya, Yoshihito Kawakami, Masutaka Furue, Chikage Mitoma
BACKGROUND: Persistent ultraviolet (UV) radiation in the form of sunlight causes photo-aging of the skin by reducing the production of type I collagen, the major constituent of the extracellular matrix of the dermis. Transforming growth factor (TGF)-β transforms dermal fibroblasts into α2-smooth muscle actin (ACTA2)-expressing myofibroblasts. Myofibroblasts produce a precursor form of type I collagen, type I procollagen (collagen I), consisting of pro-alpha1 (produced by the COL1A1 gene) and pro-alpha2 chains (produced by the COL1A2 gene)...
October 16, 2017: Journal of Dermatological Science
https://www.readbyqxmd.com/read/29078341/alk-and-ltk-ligands-are-essential-for-iridophore-development-in-zebrafish-mediated-by-the-receptor-tyrosine-kinase-ltk
#17
Elizabeth S Mo, Qianni Cheng, Andrey V Reshetnyak, Joseph Schlessinger, Stefania Nicoli
Anaplastic lymphoma kinase (Alk) and leucocyte tyrosine kinase (Ltk) were identified as "orphan" receptor tyrosine kinases (RTKs) with oncogenic potential. Recently ALKAL1 and ALKAL2 (also named "augmentor-β" and "augmentor-α" or "FAM150A" and "FAM150B," respectively) were discovered as physiological ligands of Alk and Ltk. Here, we employ zebrafish as a model system to explore the physiological function and to characterize in vivo links between Alk and Ltk with their ligands. Unlike the two ligands encoded by mammalian genomes, the zebrafish genome contains three genes: aug-α1, aug-α2, and aug-β Our experiments demonstrate that these ligands play an important role in zebrafish pigment development...
October 23, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29070432/corrigendum-to-prodepressant-and-anxiogenic-like-effects-of-serotonin-selective-but-not-noradrenaline-selective-antidepressant-agents-in-mice-lacking-%C3%AE-2-containing-gabaa-receptors-behav-brain-res-332-2017-172-179
#18
Rebecca S Benham, Nishani B Hewage, Raymond F Suckow, Elif Engin, Uwe Rudolph
No abstract text is available yet for this article.
October 22, 2017: Behavioural Brain Research
https://www.readbyqxmd.com/read/29069780/induction-of-gd3-%C3%AE-1-adrenergic-receptor-transglutaminase-2-mediated-erythroid-differentiation-in-chronic-myelogenous-leukemic-k562-cells
#19
Sun-Hyung Ha, Sung-Koo Kang, Hyunju Choi, Choong-Hwan Kwak, Fukushi Abekura, Jun-Young Park, Kyung-Min Kwon, Hyeun-Wook Chang, Young-Choon Lee, Ki-Tae Ha, Bo Kyeng Hou, Tae-Wook Chung, Cheorl-Ho Kim
The disialic acid-containing glycosphingolipid GD3 recruited membrane transglutaminase 2 (TG2) as a signaling molecule for erythroid differentiation in human chronic myelogenous leukemia (CML) K562 cells. The α1-adrenergic receptor (α1-AR)/TG2-mediated signaling pathway regulated GD3 functions, including gene expression and production, to differentiate CML K562 cells into erythroid lineage cells. Epinephrine, an AR agonist, increased membrane recruitment as well as GTP-photoaffinity of TG2, inducing GD3 synthase gene expression...
September 22, 2017: Oncotarget
https://www.readbyqxmd.com/read/29069083/rhogef9-splice-isoforms-influence-neuronal-maturation-and-synapse-formation-downstream-of-%C3%AE-2-gabaa-receptors
#20
Claire de Groot, Amalia Floriou-Servou, Yuan-Chen Tsai, Simon Früh, Manuela Kohler, Georgia Parkin, Cornelia Schwerdel, Giovanna Bosshard, Kai Kaila, Jean-Marc Fritschy, Shiva K Tyagarajan
In developing brain neuronal migration, dendrite outgrowth and dendritic spine outgrowth are controlled by Cdc42, a small GTPase of the Rho family, and its activators. Cdc42 function in promoting actin polymerization is crucial for glutamatergic synapse regulation. Here, we focus on GABAergic synapse-specific activator of Cdc42, collybistin (CB) and examine functional differences between its splice isoforms CB1 and CB2. We report that CB1 and CB2 differentially regulate GABAergic synapse formation in vitro along proximal-distal axis and adult-born neuron maturation in vivo...
October 2017: PLoS Genetics
keyword
keyword
107008
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"