keyword
MENU ▼
Read by QxMD icon Read
search

airway vagal

keyword
https://www.readbyqxmd.com/read/27820848/acid-sensing-ion-channel-1a-contributes-to-airway-hyperreactivity-in-mice
#1
Leah R Reznikov, David K Meyerholz, Ryan J Adam, Mahmoud Abou Alaiwa, Omar Jaffer, Andrew S Michalski, Linda S Powers, Margaret P Price, David A Stoltz, Michael J Welsh
Neurons innervating the airways contribute to airway hyperreactivity (AHR), a hallmark feature of asthma. Several observations suggested that acid-sensing ion channels (ASICs), neuronal cation channels activated by protons, might contribute to AHR. For example, ASICs are found in vagal sensory neurons that innervate airways, and asthmatic airways can become acidic. Moreover, airway acidification activates ASIC currents and depolarizes neurons innervating airways. We found ASIC1a protein in vagal ganglia neurons, but not airway epithelium or smooth muscle...
2016: PloS One
https://www.readbyqxmd.com/read/27685879/critical-airway-compromise-due-to-a-massive-vagal-schwannoma
#2
A M McDermott, M Sadadcharam, B J Manning, P Sheahan
We describe the case of a 37-year-old man with a slowly enlarging neck lump and compressive symptoms. He presented to a separate institution 10 years prior where an observational approach was advocated. Following preoperative investigations and embolization, an 11cm vagal schwannoma was excised and vagus nerve was sacrificed. Although conservative management is appropriate for a select patient population, surgical excision is treatment of choice for cervical neurogenic tumours and paraganglionomas and must be considered in young patients or rapidly expanding tumours to avoid compressive symptoms, as in this case...
2016: Irish Medical Journal
https://www.readbyqxmd.com/read/27621379/w-ritchie-russell-a-b-baker-and-fred-plum-pioneers-of-ventilatory-management-in-poliomyelitis
#3
Eelco F M Wijdicks
Historically, neurologists were not involved in the day-to-day management of critically ill patients with bulbar poliomyelitis, but some were. The major contributions of 3 neurologists-W. Ritchie Russell, A.B. Baker, and Fred Plum-in the respiratory management of poliomyelitis have not been recognized. Russell's work was instrumental in identifying multiple types of poliomyelitis defined by their respiratory needs, and he advised treatment that varied from simple postural drainage to use of respirators. He participated in the development of the Radcliffe respiratory pump...
September 13, 2016: Neurology
https://www.readbyqxmd.com/read/27607589/assessing-the-effects-of-a-new-cervical-pillow-on-pain-and-sleep-quality-in-recreational-athletes-with-chronic-mechanical-neck-pain-a-preliminary-comparative-study
#4
Alessandra Di Cagno, Carlo Minganti, Federico Quaranta, Eugenio M Pistone, Federica Fagnani, Giovanni Fiorilli, Arrigo Giombini
BACKGROUND: The aim of this intervention study was to determine the effects of a new experimental cervical pillow, on symptomatic adults affected by chronic mechanical neck pain. METHODS: Twelve recreational athletes of both sexes (mean age 40.5 years; range 35-55), affected by grade II chronic mechanical neck pain, were evaluated with a daily diary type of self- report questionnaire, which incorporated an 11-point Numerical Rating Pain Scale, to collect the primary outcome measures of pre and post-sleep neck pain and with the Neck Pain Disability Scale...
September 8, 2016: Journal of Sports Medicine and Physical Fitness
https://www.readbyqxmd.com/read/27497331/sudden-death-due-to-rupture-of-the-right-internal-carotid-artery-in-neurofibromatosis-type-1-a-case-report
#5
Yue Liang, Fang Tong, Lin Zhang, Wenhe Li, Yiwu Zhou
Vascular involvement is a well-recognized manifestation of neurofibromatosis type 1 (NF1) which has the potential to be fatal when disrupted. We here present a case of sudden death due to the fatal arterial rupture resulted from infiltration of the neurofibromas. A 42-year-old man who suffered from NF1 presented a 1-h history of sudden onset of pain in his right cervical region. His condition worsened and became unconscious on his way to the emergency room. Despite resuscitation efforts, he died 30min later without regaining consciousness...
July 2016: Legal Medicine
https://www.readbyqxmd.com/read/27492525/can-bronchial-asthma-with-an-highly-prevalent-airway-and-systemic-vagal-tone-be-considered-an-independent-asthma-phenotype-possible-role-of-anticholinergics
#6
Gennaro Liccardi, Antonello Salzillo, Luigino Calzetta, Mario Cazzola, Maria Gabriella Matera, Paola Rogliani
Recently, we studied occurrence and role of non-respiratory symptoms (n-RSs) before a worsening of asthma symptoms. Some n-RSs such as anxiety, reflux, heartburn, abdominal pain, which appeared within 3 h before the onset of an asthma attack, are the likely result of an imbalance between sympathetic/parasympathetic systems with an increase in cholinergic tone. Therefore, it is likely that some of these n-RSs induced by the increased cholinergic tone might be present related with specific parasympathetic-associated respiratory symptoms such as those elicited by airway narrowing...
August 2016: Respiratory Medicine
https://www.readbyqxmd.com/read/27451958/mechanisms-of-the-acute-effects-of-inhaled-ozone-in-humans
#7
REVIEW
Philip A Bromberg
Ambient air ozone (O3) is generated photochemically from oxides of nitrogen and volatile hydrocarbons. Inhaled O3 causes remarkably reversible acute lung function changes and inflammation. Approximately 80% of inhaled O3 is deposited on the airways. O3 reacts rapidly with CC double bonds in hydrophobic airway and alveolar surfactant-associated phospholipids and cholesterol. Resultant primary ozonides further react to generate bioactive hydrophilic products that also initiate lipid peroxidation leading to eicosanoids and isoprostanes of varying electrophilicity...
December 2016: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/27445853/inflammatory-role-of-ros-sensitive-amp-activated-protein-kinase-in-the-hypersensitivity-of-lung-vagal-c-fibers-induced-by-intermittent-hypoxia-in-rats
#8
Chang-Huan Yang, Yan-Jhih Shen, Ching Jung Lai, Yu Ru Kou
Obstructive sleep apnea (OSA), manifested by airway exposure to intermittent hypoxia (IH), is associated with excess reactive oxygen species (ROS) production in airways, airway inflammation, and hyperreactive airway diseases. The cause-effect relationship for these events remains unclear. We investigated the inflammatory role of ROS-sensitive AMP-activated protein kinase (AMPK) in IH-induced airway hypersensitivity mediated by lung vagal C fibers (LVCFs) in rats. Conscious rats were exposed to room air (RA) or IH with or without treatment with N-acetyl-L-cysteine (NAC, an antioxidant), Compound C (an AMPK inhibitor), ibuprofen (a cyclooxygenase inhibitor), or their vehicles...
2016: Frontiers in Physiology
https://www.readbyqxmd.com/read/27434663/limonene-and-its-ozone-initiated-reaction-products-attenuate-allergic-lung-inflammation-in-mice
#9
Jitka S Hansen, Asger W Nørgaard, Ismo K Koponen, Jorid B Sørli, Maya D Paidi, Søren W K Hansen, Per Axel Clausen, Gunnar D Nielsen, Peder Wolkoff, Søren Thor Larsen
Inhalation of indoor air pollutants may cause airway irritation and inflammation and is suspected to worsen allergic reactions. Inflammation may be due to mucosal damage, upper (sensory) and lower (pulmonary) airway irritation due to activation of the trigeminal and vagal nerves, respectively, and to neurogenic inflammation. The terpene, d-limonene, is used as a fragrance in numerous consumer products. When limonene reacts with the pulmonary irritant ozone, a complex mixture of gas and particle phase products is formed, which causes sensory irritation...
July 19, 2016: Journal of Immunotoxicology
https://www.readbyqxmd.com/read/27328978/activation-of-cannabinoid-cb1-receptors-suppresses-the-ros-induced-hypersensitivity-of-rat-vagal-lung-c-fiber-afferents
#10
Chou-Ming Yeh, Ting Ruan, Yu-Jung Lin, Tien-Huan Hsu
BACKGROUND: Reactive oxygen species (ROS), including H2O2, have been shown to induce hypersensitivity of vagal lung C-fibers (VLCFs) mainly through receptor potential ankyrin 1 (TRPA1) and P2X receptors. Cannabinoids (CBs) exert antinociceptive effects by binding to specific CB receptors, designated CB1 and CB2 (type 2) for type 1 and type 2, respectively. We investigated whether activation of CB receptors can suppress ROS-mediated VLCF hypersensitivity and, if so, what type(s) of CB receptors are involved...
October 2016: Pulmonary Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/27279650/vagal-afferent-innervation-of-the-airways-in-health-and-disease
#11
REVIEW
Stuart B Mazzone, Bradley J Undem
Vagal sensory neurons constitute the major afferent supply to the airways and lungs. Subsets of afferents are defined by their embryological origin, molecular profile, neurochemistry, functionality, and anatomical organization, and collectively these nerves are essential for the regulation of respiratory physiology and pulmonary defense through local responses and centrally mediated neural pathways. Mechanical and chemical activation of airway afferents depends on a myriad of ionic and receptor-mediated signaling, much of which has yet to be fully explored...
July 2016: Physiological Reviews
https://www.readbyqxmd.com/read/27242540/nadph-oxidase-derived-ros-induced-by-chronic-intermittent-hypoxia-mediates-hypersensitivity-of-lung-vagal-c-fibers-in-rats
#12
Chang-Huan Yang, Wei-Ling Zhuang, Yan-Jhih Shen, Ching Jung Lai, Yu Ru Kou
Obstructive sleep apnea (OSA), manifested by exposure to chronic intermittent hypoxia (CIH) and excess production of reactive oxygen species (ROS) in the airways, is associated with hyperreactive airway diseases. ROS, particularly when created by NADPH oxidase, are known to sensitize lung vagal C fibers (LVCFs), which may contribute to airway hypersensitivity pathogenesis. We investigated whether CIH augments the reflex and afferent responses of LVCFs to chemical stimulants and the roles of ROS and NADPH oxidase in such airway hypersensitivity...
2016: Frontiers in Physiology
https://www.readbyqxmd.com/read/27184303/changes-in-vagal-afferent-drive-alter-tracheobronchial-coughing-in-anesthetized-cats
#13
Michal Simera, Ivan Poliacek, Marcel Veternik, Lucia Babalova, Zuzana Kotmanova, Jan Jakus
Unilateral cooling of the vagus nerve (<5°C, blocking mainly conductivity of myelinated fibers) and unilateral vagotomy were employed to reduce cough afferent drive in order to evaluate the effects of these interventions on the temporal features of the cough reflex. Twenty pentobarbitone anesthetized, spontaneously breathing cats were used. Cough was induced by mechanical stimulation of the tracheobronchial airways. The number of coughs during vagal cooling was significantly decreased (p<0.001). Inspiratory cough efforts were reduced by approximately 30% (p<0...
August 2016: Respiratory Physiology & Neurobiology
https://www.readbyqxmd.com/read/27168016/a-method-to-target-and-isolate-airway-innervating-sensory-neurons-in-mice
#14
Melanie Maya Kaelberer, Sven-Eric Jordt
Somatosensory nerves transduce thermal, mechanical, chemical, and noxious stimuli caused by both endogenous and environmental agents. The cell bodies of these afferent neurons are located within the sensory ganglia. Sensory ganglia innervate a specific organ or portion of the body. For instance, the dorsal root ganglia (DRG) are located in the vertebral column and extend processes throughout the body and limbs. The trigeminal ganglia are located in the skull and innervate the face, and upper airways. Vagal afferents of the nodose ganglia extend throughout the gut, heart, and lungs...
2016: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/27133202/intracerebroventricular-injections-of-dronabinol-a-cannabinoid-receptor-agonist-does-not-attenuate-serotonin-induced-apnea-in-sprague-dawley-rats
#15
Michael W Calik, David W Carley
BACKGROUND: Evidence suggests that vagal nerve activity may play a role in sleep apnea induction. In anesthetized rats, dronabinol, a cannabinoid (CB) receptor agonist, injected into the nodose ganglia attenuates reflex apnea and increases genioglossus activity, and reflex apnea attenuation is blocked by systemic pre-treatment with cannabinoid type 1 and/or type 2 receptor antagonists. However, it is unclear whether dronabinol has similar effects in the central nervous system; CB receptors are widely distributed in the brain, especially on neuronal circuitry important for respiration and upper airway activation...
2016: Journal of Negative Results in Biomedicine
https://www.readbyqxmd.com/read/27049312/vagal-nerve-stimulation-attenuates-il-6-and-tnf%C3%AE-expression-in-respiratory-regions-of-the-developing-rat-brainstem
#16
Rhaya L Johnson, Samuel T Murray, David K Camacho, Christopher G Wilson
Pre-term infants are at greater risk for systemic infection due to an underdeveloped immune system. Airway infection results in immune up-regulation of early pro-inflammatory cytokines interleukin-1β (IL-1β), interleukin-6 (IL-6) and tumor necrosis factor-α (TNFα) in the brainstem. Current treatment for neonatal infection involves antibiotic administration. We previously showed that LPS injected into the trachea of neonatal rats causes changes in breathing and in IL-1β expression in the nucleus tractus solitarii (NTS) and hypoglossal motor nucleus (XII)...
July 15, 2016: Respiratory Physiology & Neurobiology
https://www.readbyqxmd.com/read/26973533/activation-of-trpv4-regulates-respiration-through-indirect-activation-of-bronchopulmonary-sensory-neurons
#17
Qihai David Gu, Charles R Moss, Kristen L Kettelhut, Carolyn A Gilbert, Hongzhen Hu
Transient receptor potential vanilloid receptor 4 (TRPV4) is a calcium-permeable non-selective cation channel implicated in numerous physiological and pathological functions. This study aimed to investigate the effect of TRPV4 activation on respiration and to explore the potential involvement of bronchopulmonary sensory neurons. Potent TRPV4 agonist GSK1016790A was injected into right atrium in anesthetized spontaneously breathing rats and the changes in breathing were measured. Patch-clamp recording was performed to investigate the effect of GSK1016790A or another TRPV4 activator 4α-PDD on cultured rat vagal bronchopulmonary sensory neurons...
2016: Frontiers in Physiology
https://www.readbyqxmd.com/read/26957719/influence-of-bilevel-positive-airway-pressure-on-autonomic-tone-in-hospitalized-patients-with-decompensated-heart-failure
#18
Diego Lacerda, Dirceu Costa, Michel Reis, Evelim Leal de F Dantas Gomes, Ivan Peres Costa, Audrey Borghi-Silva, Aline Marsico, Roberto Stirbulov, Ross Arena, Luciana Maria Malosá Sampaio
[Purpose] This study evaluated the effect of Bilevel Positive Airway (BiPAP) on the autonomic control of heart rate, assessed by heart rate variability (HRV), in patients hospitalized with decompensated heart failure. [Subjects and Methods] This prospective cross-sectional study included 20 subjects (age: 69±8 years, 12 male, left ventricular ejection fraction: 36 ±8%) diagnosed with heart failure who were admitted to a semi-intensive care unit with acute decompensation. Date was collected for HRV analysis during: 10 minutes spontaneous breathing in the resting supine position; 30 minutes breathing with BiPAP application (inspiratory pressure = 20 cmH2O and expiratory pressure = 10 cmH2O); and 10 minutes immediately after removal of BiPAP, during the return to spontaneous breathing...
January 2016: Journal of Physical Therapy Science
https://www.readbyqxmd.com/read/26933707/dyspnoea-pathophysiology-and-a-clinical-approach
#19
REVIEW
C B I Coccia, G H Palkowski, B Schweitzer, T Motsohi, N A B Ntusi
Dyspnoea, also known as shortness of breath or breathlessness, is a subjective awareness of the sensation of uncomfortable breathing. It may be of physiological, pathological or social origin. The pathophysiology of dyspnoea is complex, and involves the activation of several pathways that lead to increased work of breathing, stimulation of the receptors of the upper or lower airway, lung parenchyma, or chest wall, and excessive stimulation of the respiratory centre by central and peripheral chemoreceptors. Activation of these pathways is relayed to the central nervous system via respiratory muscle and vagal afferents, which are consequently interpreted by the individual in the context of the affective state, attention, and prior experience, resulting in the awareness of breathing...
January 2016: South African Medical Journal, Suid-Afrikaanse Tydskrif Vir Geneeskunde
https://www.readbyqxmd.com/read/26926080/effect-of-transient-receptor-potential-vanilloid-1-on-cough-hypersensitivity-induced-by-particulate-matter-2-5
#20
Haining Lv, Jianliang Yue, Zhe Chen, Senlin Chai, Xu Cao, Jie Zhan, Zhenjun Ji, Hui Zhang, Rong Dong, Kefang Lai
AIMS: The mechanism of cough hypersensitivity induced by particulate matter 2.5 (PM2.5) remains elusive. The current study was designed to explore the effect of transient receptor potential vanilloid-1 (TRPV1) on cough hypersensitivity in airway and central nervous system. MAIN METHODS: The PM2.5-induced chronic cough model of guinea pig was established by exposure to different doses of PM2.5 for three weeks. After exposure, the animals were microinjected with TRPV1 agonist capsaicine, antagonist capsazepine in the dorsal vagal complex respectively...
April 15, 2016: Life Sciences
keyword
keyword
107006
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"