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https://www.readbyqxmd.com/read/27922851/future-prospects-for-new-vaccines-against-sexually-transmitted-infections
#1
Sami L Gottlieb, Christine Johnston
PURPOSE OF REVIEW: This review provides an update on the need, development status, and important next steps for advancing development of vaccines against sexually transmitted infections (STIs), including herpes simplex virus (HSV), Neisseria gonorrhoeae (gonorrhea), Chlamydia trachomatis (chlamydia), and Treponema pallidum (syphilis). RECENT FINDINGS: Global estimates suggest that more than a million STIs are acquired every day, and many new and emerging challenges to STI control highlight the critical need for development of new STI vaccines...
December 2, 2016: Current Opinion in Infectious Diseases
https://www.readbyqxmd.com/read/27905140/herpes-simplex-infection-simulating-richter-transformation-a-series-of-four-cases-and-review-of-the-literature
#2
Alireza Salem, Sanam Loghavi, Joseph D Khoury, Rose Lou Marie C Agbay, Jeffrey L Jorgensen, Jeffrey L Medeiros
AIMS: Richter transformation (RT) occurs in 5-10% of patients with chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL) and is associated with a poor outcome. Histologic manifestations of RT are variable and include an increase in the proportion of large cells including prolymphocytes, immunoblasts and other pleomorphic cells along with an increased proliferation rate and often necrosis. Rarely, superimposed Herpes simplex virus (HSV) infection involving lymph nodes in patients with CLL/SLL may mimic RT clinically and histologically...
December 1, 2016: Histopathology
https://www.readbyqxmd.com/read/27894330/marek-s-disease-in-chickens-a-review-with-focus-on-immunology
#3
REVIEW
Nitish Boodhoo, Angila Gurung, Shayan Sharif, Shahriar Behboudi
Marek's disease (MD), caused by Marek's disease virus (MDV), is a commercially important neoplastic disease of poultry which is only controlled by mass vaccination. Importantly, vaccines that can provide sterile immunity and inhibit virus transmission are lacking; such that vaccines are only capable of preventing neuropathy, oncogenic disease and immunosuppression, but are unable to prevent MDV transmission or infection, leading to emergence of increasingly virulent pathotypes. Hence, to address these issues, developing more efficacious vaccines that induce sterile immunity have become one of the important research goals for avian immunologists today...
November 28, 2016: Veterinary Research
https://www.readbyqxmd.com/read/27853930/a-systematic-review-of-oral-herpetic-viral-infections-in-cancer-patients-commonly-used-outcome-measures-and-interventions
#4
Sharon Elad, Vinisha Ranna, Anura Ariyawardana, Maria Elvira Pizzigatti Correa, Vanessa Tilly, Raj G Nair, Tanya Rouleau, Richard M Logan, Andres Pinto, Veronica Charette, Debbie P Saunders, Siri Beier Jensen
PURPOSE: To review the literature for outcome measures for oral viral infections in cancer patients. A secondary aim was to update the Multinational Association of Supportive Care in Cancer/International Society of Oral Oncology (MASCC/ISOO) clinical practice guidelines for the management of oral viral infections in cancer patients. METHODS: Databases were searched for articles published in the English language, 1981-2013. Studies that met the eligibility criteria were reviewed systematically...
November 16, 2016: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
https://www.readbyqxmd.com/read/27824221/school-based-interventions-for-preventing-hiv-sexually-transmitted-infections-and-pregnancy-in-adolescents
#5
REVIEW
Amanda J Mason-Jones, David Sinclair, Catherine Mathews, Ashraf Kagee, Alex Hillman, Carl Lombard
BACKGROUND: School-based sexual and reproductive health programmes are widely accepted as an approach to reducing high-risk sexual behaviour among adolescents. Many studies and systematic reviews have concentrated on measuring effects on knowledge or self-reported behaviour rather than biological outcomes, such as pregnancy or prevalence of sexually transmitted infections (STIs). OBJECTIVES: To evaluate the effects of school-based sexual and reproductive health programmes on sexually transmitted infections (such as HIV, herpes simplex virus, and syphilis), and pregnancy among adolescents...
November 8, 2016: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/27793330/otorhinolaryngology-manifestations-secondary-to-oral-sex
#6
Claudia Fernández-López, Carmelo Morales-Angulo
INTRODUCTION: Over the last few years, oral and pharyngeal signs and symptoms due to oral sex have increased significantly. However, no review articles related to this subject have been found in the medical literature. The objective of our study was to identify otorhinolaryngological manifestations associated with orogenital/oroanal contact, both in adults and children, in the context of consensual sex or sexual abuse. METHODS: We performed a review of the medical literature on otorhinolaryngological pathology associated with oral sex published in the last 20 years in the PubMed database...
October 25, 2016: Acta Otorrinolaringológica Española
https://www.readbyqxmd.com/read/27761420/a-review-study-on-the-effect-of-iranian-herbal-medicines-against-in-vitro-replication-of-herpes-simplex-virus
#7
Mohammad-Taghi Moradi, Mahmoud Rafieian-Kopaei, Ali Karimi
OBJECTIVE: There are a number of published data indicating in vitro anti-HSV activity of some of Iranian herbal extracts with no systematic review to discuss these results. Therefore, this article was aimed to review and discuss the methods carried out and the phytochemistry and bioactivity of the extracts used and also conclusions provided in these publications. MATERIALS AND METHODS: Published articles both in English (from Medline, Science Direct, EMBASE, Scopus, Pro Quest, Google scholar, Cochrane Library) and in Persian (from SID, Iran Medex and Magiran) databases, from 1966 to October 2014 were incorporated in this review...
September 2016: Avicenna Journal of Phytomedicine
https://www.readbyqxmd.com/read/27746159/modulation-of-host-defence-against-bacterial-and-viral-infections-by-omega-3-polyunsaturated-fatty-acids
#8
REVIEW
Marie-Odile Husson, Delphine Ley, Céline Portal, Madeleine Gottrand, Thomas Hueso, Jean-Luc Desseyn, Frédéric Gottrand
OBJECTIVES: Although n-3 long-chain polyunsaturated fatty acids (n-3 LC-PUFAs) are used widely in the treatment of chronic inflammatory diseases, their effect in infectious disease requires a particular attention. METHODS: The present article discusses their anti-inflammatory and immune properties involved in the host defence and presents a systematic review of the effects of their oral administration on the prevention and outcome of experimental and clinical infections...
December 2016: Journal of Infection
https://www.readbyqxmd.com/read/27724886/school-based-sexual-health-education-interventions-to-prevent-sti-hiv-in-sub-saharan-africa-a-systematic-review-and-meta-analysis
#9
A Sadiq Sani, Charles Abraham, Sarah Denford, Susan Ball
BACKGROUND: School-based sexual health education has the potential to provide an inclusive and comprehensive approach to promoting sexual health among young people. We reviewed evaluations of school-based sexual health education interventions in sub-Saharan Africa to assess effectiveness in reducing sexually transmitted infections and promoting condom use. METHODS: We searched ten electronic databases, hand-searched key journals, and reference lists of included articles for potential studies...
October 10, 2016: BMC Public Health
https://www.readbyqxmd.com/read/27562285/-behcet-s-disease-and-infection
#10
M H Pei, M F Zhang
Behcet's disease (BD) is a systemic vasculitis of unknown etiology. Uveitis, which is common and therapeutically challenging, is the major ocular manifestation of BD. Researches have shown that, in addition to the genetic components (e.g. HLA-B51), environmental factors such as infection also play important roles in the pathogenesis of BD. In recent years, with the advances in bio-detecting technologies, accumulating evidence has shown an association between microbial infections and previously believed non-infectious immune disorders...
August 2016: [Zhonghua Yan Ke za Zhi] Chinese Journal of Ophthalmology
https://www.readbyqxmd.com/read/27516203/talimogene-laherparepvec-a-review-in-unresectable-metastatic-melanoma
#11
Karly P Garnock-Jones
Talimogene laherparepvec (Imlygic™) is a first-in-class oncolytic viral immunotherapy derived from herpes simplex virus type 1, which has been genetically modified to increase tumour selectivity and stimulate antitumour immune response. This article reviews the pharmacological properties of intralesional talimogene laherparepvec and its clinical efficacy and tolerability in patients with unresectable metastatic melanoma. In the phase III OPTiM trial, talimogene laherparepvec was more effective than subcutaneous human granulocyte-macrophage colony-stimulating factor (GM-CSF), both in patients with stage IIIB-IV melanoma [intention-to-treat (ITT) population] and in those with stage IIIB-IVM1a disease (in an exploratory subgroup analysis)...
October 2016: BioDrugs: Clinical Immunotherapeutics, Biopharmaceuticals and Gene Therapy
https://www.readbyqxmd.com/read/27515422/human-herpes-viruses-in-burn-patients-a-systematic-review
#12
Paul Wurzer, Ashley Guillory, Daryousch Parvizi, Robert P Clayton, Ludwik K Branski, Lars-P Kamolz, Celeste C Finnerty, David N Herndon, Jong O Lee
OBJECTIVE: The contribution of human herpes viruses, including herpes simplex virus (HSV), cytomegalovirus (CMV), and varicella zoster virus (VZV) to morbidity and mortality after burns remains controversial. This systematic review was undertaken to assess evidence of herpes virus-related morbidity and mortality in burns. MATERIALS AND METHODS: PubMed, Ovid, and Web of Science were searched to identify studies of HSV, CMV, or VZV infections in burn patients. Exclusion criteria included: A level of evidence (LoE) of IV or V; nonhuman in vivo studies; and non-English articles...
August 8, 2016: Burns: Journal of the International Society for Burn Injuries
https://www.readbyqxmd.com/read/27486853/oncolytic-virus-therapy-a-new-era-of-cancer-treatment-at-dawn
#13
REVIEW
Hiroshi Fukuhara, Yasushi Ino, Tomoki Todo
Oncolytic virus therapy is perhaps the next major breakthrough in cancer treatment following the success in immunotherapy using immune checkpoint inhibitors. Oncolytic viruses are defined as genetically engineered or naturally occurring viruses that selectively replicate in and kill cancer cells without harming the normal tissues. T-Vec (talimogene laherparepvec), a second-generation oncolytic herpes simplex virus type 1 (HSV-1) armed with GM-CSF, was recently approved as the first oncolytic virus drug in the USA and Europe...
October 2016: Cancer Science
https://www.readbyqxmd.com/read/27377298/bacterial-and-viral-infections-in-atopic-dermatitis-a-comprehensive-review
#14
Peck Y Ong, Donald Y M Leung
Atopic dermatitis (AD) is the most common allergic skin disease in the general population. It is a chronic inflammatory skin disease complicated by recurrent bacterial and viral infections that, when left untreated, can lead to significant complications. The current article will review immunologic and molecular mechanisms underlying the propensity of AD patients to microbial infections. These infections include Staphylococcus aureus (S. aureus) skin infections, eczema herpeticum, eczema vaccinatum, and eczema coxsackium...
July 5, 2016: Clinical Reviews in Allergy & Immunology
https://www.readbyqxmd.com/read/27343062/hsv-1-tegument-protein-and-the-development-of-its-genome-editing-technology
#15
REVIEW
Xingli Xu, Yanchun Che, Qihan Li
Herpes simplex virus 1 (HSV-1) is composed of complex structures primarily characterized by four elements: the nucleus, capsid, tegument and envelope. The tegument is an important viral component mainly distributed in the spaces between the capsid and the envelope. The development of viral genome editing technologies, such as the identification of temperature-sensitive mutations, homologous recombination, bacterial artificial chromosome, and the CRISPR/Cas9 system, has been shown to largely contribute to the rapid promotion of studies on the HSV-1 tegument protein...
June 24, 2016: Virology Journal
https://www.readbyqxmd.com/read/27105564/the-global-roadmap-for-advancing-development-of-vaccines-against-sexually-transmitted-infections-update-and-next-steps
#16
Sami L Gottlieb, Carolyn D Deal, Birgitte Giersing, Helen Rees, Gail Bolan, Christine Johnston, Peter Timms, Scott D Gray-Owen, Ann E Jerse, Caroline E Cameron, Vasee S Moorthy, James Kiarie, Nathalie Broutet
In 2014, the World Health Organization, the US National Institutes of Health, and global technical partners published a comprehensive roadmap for development of new vaccines against sexually transmitted infections (STIs). Since its publication, progress has been made in several roadmap activities: obtaining better epidemiologic data to establish the public health rationale for STI vaccines, modeling the theoretical impact of future vaccines, advancing basic science research, defining preferred product characteristics for first-generation vaccines, and encouraging investment in STI vaccine development...
June 3, 2016: Vaccine
https://www.readbyqxmd.com/read/27056850/-cognitive-impairment-in-patients-with-bacterial-meningitis-and-encephalitides
#17
REVIEW
Satoshi Kamei
Cognitive impairments, including dementia, can present as first symptoms at the acute stage, and/or as sequelae in the chronic stages, in some patients with bacterial meningitis (BM) or encephalitides. BM and encephalitides are lifethreatening neurological emergencies, and early recognition, efficient decision-making, and rapid commencement of therapy can be lifesaving. Empirical therapy should be initiated promptly whenever BM or encephalitides are a probable diagnosis. In this article cognitive impairments, including dementia, presenting in patients with BM, Herpes simplex virus encephalitis (HSVE), Human herpesvirus-6 (HHV-6) encephalitis, and Anti N-methyl-d-aspartate (NMDA) receptor encephalitis are reviewed...
April 2016: Brain and Nerve, Shinkei Kenkyū No Shinpo
https://www.readbyqxmd.com/read/27043544/the-honolulu-liver-disease-cluster-at-the-medical-center-its-mysteries-and-challenges
#18
REVIEW
Rolf Teschke, Axel Eickhoff
In 2013, physicians at the Honolulu Queen's Medical Center (QMC) noticed that seven liver disease patients reported the use of OxyELITE Pro (OEP), a widely consumed dietary supplement (DS). Assuming a temporal association between OEP use and disease, they argued that OEP was the cause of this mysterious cluster. Subsequent reexamination, however, has revealed that this QMC cohort is heterogeneous and not a cluster with a single agent causing a single disease. It is heterogeneous because patients used multiple DS's and drugs and because patients appeared to have suffered from multiple liver diseases: liver cirrhosis, liver failure by acetaminophen, hepatotoxicity by non-steroidal antiinflammatory drugs (NSAIDs), resolving acute viral hepatitis by hepatitis B virus (HBV), herpes simplex virus (HSV), and varicella zoster virus (VZV), and suspected hepatitis E virus (HEV)...
2016: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/26999187/alphaherpesvirus-subversion-of-stress-induced-translational-arrest
#19
REVIEW
Renée L Finnen, Bruce W Banfield
In this article, we provide an overview of translational arrest in eukaryotic cells in response to stress and the tactics used specifically by alphaherpesviruses to overcome translational arrest. One consequence of translational arrest is the formation of cytoplasmic compartments called stress granules (SGs). Many viruses target SGs for disruption and/or modification, including the alphaherpesvirus herpes simplex virus type 2 (HSV-2). Recently, it was discovered that HSV-2 disrupts SG formation early after infection via virion host shutoff protein (vhs), an endoribonuclease that is packaged within the HSV-2 virion...
March 2016: Viruses
https://www.readbyqxmd.com/read/26985246/systemic-immunosuppression-in-high-risk-penetrating-keratoplasty-a-systematic-review
#20
REVIEW
Shveta Bali, Richard Filek, Francie Si, William Hodge
Cornea transplantation has a high success rate and typically only requires topical immunomodulation. However, in high-risk cases, systemic immunosuppression can be used. We conducted a systematic review on the efficacy and side effects of systemic immunosuppression for high-risk cornea transplantation. The study population was 18 years old or older with a high-risk transplant (two or more clock hours of cornea vascularization or a previous failed graft or a graft needed because of herpes simplex keratitis)...
April 2016: Journal of Clinical Medicine Research
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