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Abhijit S Nair, Vibhavari Milind Naik, Basanth Kumar Rayani
No abstract text is available yet for this article.
October 2017: Indian Journal of Critical Care Medicine
Maria Azpiroz-Zabala, Matthieu J B Cartigny, Peter J Talling, Daniel R Parsons, Esther J Sumner, Michael A Clare, Stephen M Simmons, Cortis Cooper, Ed L Pope
Seabed-hugging flows called turbidity currents are the volumetrically most important process transporting sediment across our planet and form its largest sediment accumulations. We seek to understand the internal structure and behavior of turbidity currents by reanalyzing the most detailed direct measurements yet of velocities and densities within oceanic turbidity currents, obtained from weeklong flows in the Congo Canyon. We provide a new model for turbidity current structure that can explain why these are far more prolonged than all previously monitored oceanic turbidity currents, which lasted for only hours or minutes at other locations...
October 2017: Science Advances
Bryon N Hughson, Ina Anreiter, Nicholas L Jackson Chornenki, Keith R Murphy, William W Ja, Robert Huber, Marla B Sokolowski
We introduce a high-resolution adult foraging assay (AFA) that relates pre- and post-ingestive walking behavior to individual instances of food consumption. We explore the utility of the AFA by taking advantage of established rover and sitter strains known to differ in a number of feeding-related traits. The AFA allows us to effectively distinguish locomotor behavior in Fed and Food-Deprived (FD) rover and sitter foragers. We found that rovers exhibit more exploratory behavior into the center of an arena containing sucrose drops compared to sitters who hug the edges of the arena and exhibit thigmotaxic behavior...
August 30, 2017: Journal of Insect Physiology
Cléria Rodrigues Ferreira, Denis Fabiano de Souza, Thulio Marques Cunha, Marcelo Tavares, Samir Seme Arab Reis, Reginaldo Santos Pedroso, Denise Von Dolinger de Brito Röder
OBJECTIVES: The aim of this study was to evaluate the impact of a bundle called FAST HUG in ventilator-associated pneumonia, weigh the healthcare costs of ventilator-associated pneumonia patients in the intensive care unit, and hospital mortality due to ventilator-associated pneumonia. MATERIAL AND METHODS: The study was performed in a private hospital that has an 8-bed intensive care unit. It was divided into two phases: before implementing FAST HUG, from August 2011 to August 2012 and after the implementation of FAST HUG, from September 2012 to December 2013...
May 2016: Brazilian Journal of Infectious Diseases
Enrique Monares Zepeda, Carlos Alfredo Galindo Martín
Implementing a nutrition support protocol in critical care is a complex and dynamic process that involves the use of evidence, education programs and constant monitoring. To facilitate this task we developed a mnemonic tool called the Nutritional FAST HUG (F: feeding, A: analgesia, S: stools, T: trace elements, H: head of bed, U: ulcers, G: glucose control) with a process also internally developed (both modified from the mnemonic proposed by Jean Louis Vincent) called MIAR (M: measure, I: interpret, A: act, R: reanalysis) showing an easy form to perform medical rounds at the intensive care unit using a systematic process...
May 1, 2015: Nutrición Hospitalaria: Organo Oficial de la Sociedad Española de Nutrición Parenteral y Enteral
P Morlière, G L Hug, L K Patterson, J-C Mazière, J Ausseil, J-L Dupas, J-P Ducroix, R Santus, P Filipe
BACKGROUND: Excess 5-aminolevulinic acid (ALA) and α-aminoacetone (AA) are implicated in ketosis, porphyrinpathies and diabetes. Pathologic manifestations involve O₂⁻, H₂O₂, OH, enoyl radicals (ALA and AA) and their oxidation end products. METHODS: To characterize enoyl radicals resulting from reaction of OH radicals with ALA and AA, micromolar OH concentrations were produced by pulse radiolysis of ALA and AA in aqueous solutions. RESULTS: ALA and AA react with OH at k=1...
October 2014: Biochimica et Biophysica Acta
Pierre de Goumoens, Stéphane Genevay, Enrico Tessitore, Maroun Zaarour, John Michael Duff, Antonio Faundez, Constantin Schizas, Maximilian Schindler, Davide Zoccatelli, Antonio Foletti, Iohn Norberg, Liliana Belgrand, Anne-Claude Griesser, Gerit Kulik
Back pain is a considerable economical burden in industrialised countries. Its management varies widely across countries, including Switzerland. Thus, the University Hospital and University of Lausanne (CHUV) recently improved intern processes of back pain care. In an already existing collaborative context, the two university hospitals in French-speaking Switzerland (CHUV, University Hospital of Geneva), felt the need of a medical consensus, based on a common concept. This inter-hospital consensus produced three decisional algorithms that bear on recent concepts of back pain found in literature...
April 30, 2014: Revue Médicale Suisse
Paul Borer, Stephan J Hug
Colloidal mineral-phases play an important role in the adsorption, transport and transformation of organic and inorganic compounds in the atmosphere and in aqueous environments. Artificial UV-light and sunlight can induce electron transfer reactions between metal ions of the solid phases and adsorbed compounds, leading to their transformation and degradation. To investigate different possible photo-induced oxidation pathways of dicarboxylates adsorbed on iron(III)(hydr)oxide surfaces, we followed UV-A induced photoreactions of oxalate, malonate, succinate and their corresponding α-hydroxy analogues tartronate and malate with in situ ATR-FTIR spectroscopy in immersed particle layers of lepidocrocite, goethite, maghemite and hematite at pH 4...
February 15, 2014: Journal of Colloid and Interface Science
Dharshi Karalapillai, Ian Baldwin, Gillian Dunnachie, Cameron Knott, Glenn Eastwood, John Rogan, Erin Carnell, Daryl Jones
BACKGROUND: Patients admitted to intensive care units have complex care needs. Accordingly, communication and handover of the medical care plan is very important. OBJECTIVE: To assess changes in ICU nurses' understanding of the medical daily care plan after development and implementation of a pro forma to improve documentation and communication of the plan. DESIGN, SETTING AND PARTICIPANTS: The study was conducted between February and November 2012 in a mixed medical-surgical, 18-bed, closed ICU in a teaching hospital...
June 2013: Critical Care and Resuscitation: Journal of the Australasian Academy of Critical Care Medicine
Guolin Li, Wang Shi, Hui Hug, Yaqin Chen, Li Liu, Dazhong Yin
BACKGROUND: Nonalcoholic fatty liver disease (NAFLD) is associated with the increased burden of kidney. However, there is still no large population study to explore the potential relationship between NAFLD and mild kidney function damage (MKFD) after adjusted for confounding factors. This study is to test the hypothesis that NAFLD is associated with MKFD under controlling the effects of confounding factors. MATERIALS AND METHODS: Levels of serum fasting glucose, creatinine, cholesterol, triglyceride, alanine aminotransferase and aspartate aminotransferase were analyzed from 1412 Chinese Han adults...
2012: Biochemia Medica: časopis Hrvatskoga Društva Medicinskih Biokemičara
Oliver Herrmann, Andreas Hug, Julian Bösel, Juliana Johanna Petersen, Marius Hartmann, Stefan Rohde, Martin Bendszus, Peter Arthur Ringleb, Werner Hacke, Roland Veltkamp
BACKGROUND: As intravenous thrombolysis frequently fails to recanalize occluded proximal intracerebral arteries, interventional recanalization therapy is increasingly being considered as treatment option in acute ischemic stroke patients. The optimal periprocedural patient management for these interventions is currently unknown. The aim of this study was to identify factors delaying door-to-treatment times, and to evaluate the effect of a fast-track intubation standard operating procedure (I-SOP) on door-to-angiography time...
December 2012: Neurocritical Care
Giovanni Fava, Lamberto Widesott, Francesco Fellin, Maurizio Amichetti, Valentina Viesi, Antony J Lomax, Lydia Lederer, Eugen B Hug, Claudio Fiorino, Giovannella Salvadori, Nadia Di Muzio, Marco Schwarz
PURPOSE: We estimated the potential advantage of remote positioning (RP) vs. in-room positioning (IP) for a proton therapy facility in terms of patient throughput. MATERIALS AND METHODS: Monte Carlo simulations of facilities with one, two or three gantries were performed. A sensitivity analysis was applied by varying the imaging and setup correction system (ICS), the speed of transporters (for RP) and beam switching time. Possible advantages of using three couches (for RP) or of switching the beam between fields was also investigated...
April 2012: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
Richat Abbas, Bruce A Hug, Cathie Leister, Myriam El Gaaloul, Stephan Chalon, Daryl Sonnichsen
PURPOSE: Bosutinib (SKI-606), a dual Src/Abl tyrosine kinase inhibitor, is in clinical development for the treatment of patients with chronic myelogenous leukemia (CML). To support clinical development, we conducted a dose-escalation and food-effect evaluation of safety, tolerability, and pharmacokinetics (PK) of bosutinib in healthy adults. METHODS: This was a randomized, double-blind, placebo-controlled, single-ascending dose, sequential-group study of oral bosutinib...
January 2012: Cancer Chemotherapy and Pharmacology
G E Schröder-Turk, W Mickel, S C Kapfer, M A Klatt, F M Schaller, M J F Hoffmann, N Kleppmann, P Armstrong, A Inayat, D Hug, M Reichelsdorfer, W Peukert, W Schwieger, K Mecke
Predicting physical properties of materials with spatially complex structures is one of the most challenging problems in material science. One key to a better understanding of such materials is the geometric characterization of their spatial structure. Minkowski tensors are tensorial shape indices that allow quantitative characterization of the anisotropy of complex materials and are particularly well suited for developing structure-property relationships for tensor-valued or orientation-dependent physical properties...
June 17, 2011: Advanced Materials
Richat Abbas, Bruce A Hug, Cathie Leister, Jaime Burns, Daryl Sonnichsen
AIM: The primary objective was to evaluate the pharmacokinetics of a single dose of neratinib, a potent, low-molecular-weight, orally administered, irreversible pan-ErbB (ErbB-1, -2, -4) receptor tyrosine kinase inhibitor, during co-administration with ketoconazole, a potent CYP3A4 inhibitor. METHODS: This was an open-label, randomized, two-period, crossover study. Fasting healthy adults received a single oral dose of neratinib 240 mg alone and with multiple oral doses of ketoconazole 400 mg...
April 2011: British Journal of Clinical Pharmacology
Richat Abbas, Bruce A Hug, Cathie Leister, Jaime Burns, Daryl Sonnichsen
Bosutinib (SKI-606), a dual inhibitor of Src and Abl tyrosine kinases, is being developed for the treatment of chronic myelogenous leukemia. The effect of coadministration of ketoconazole on the pharmacokinetic (PK) profile of bosutinib was evaluated in an open-label, randomized, 2-period, crossover study. Healthy subjects (fasting) received a single dose of oral bosutinib 100 mg alone and with multiple once-daily doses of oral ketoconazole 400 mg. PK sampling occurred through 96 hours. The least square geometric mean treatment ratios (90% confidence interval [CI]) of C(max(bosutinib+ketoconazole))/C(max(bosutinib alone)), AUC(T(bosutinib+ketoconazole))/AUC(T(bosutinib alone)), and AUC((bosutinib+ketoconazole))/AUC((bosutinib alone)) were assessed...
December 2011: Journal of Clinical Pharmacology
Anna Lewandowska, Gordon L Hug, Gerald Hörner, Tomasz Pedzinski, Piotr Filipiak, Bronislaw Marciniak
The dynamics of the bimolecular quenching of triplet excited benzophenone by anisole was studied by nanosecond flash photolysis. We carried out a detailed study of the solvent dependence of the reaction rates and efficiencies in a number of protic and non-protic solvents. These studies were augmented by theoretical modelling and experimental investigation of solute/solvent interactions in the triplet excited and the ground state, respectively. The triplet quenching that follows Stern-Volmer kinetics in all cases is profoundly dependent on the nature of the solvent, with the highest reactivity being consistently found in protic solvents...
July 12, 2010: Chemphyschem: a European Journal of Chemical Physics and Physical Chemistry
Timolaos Rizos, Ekkehart Jenetzky, Christian Herweh, Andreas Hug, Werner Hacke, Thorsten Steiner, Roland Veltkamp
OBJECTIVE: Rapid reversal of the anticoagulatory effect of vitamin K antagonists represents the primary emergency treatment for oral anticoagulant-related intracerebral hemorrhage (OAC-ICH). Predicting the amount of prothrombin complex concentrate (PCC) needed to reverse OAC in individual patients is difficult, and repeated international normalized ratio (INR) measurements in central laboratories (CLs) are time-consuming. Accuracy and effectiveness of point-of-care INR coagulometers (POCs) for INR reversal in OAC-ICH have not been evaluated...
June 2010: Annals of Neurology
P T Heighes, G S Doig, E A Sweetman, F Simpson
International quality improvement initiatives such as Fast-Hug bring a focus on improving the delivery of early enteral nutrition to critically ill patients, however surveys demonstrate current practice remains variable. One way to reduce variability in practice is to provide strong evidence to convince clinicians to change. The purpose of this overview was to identify current best evidence supporting the delivery of early enteral nutrition in critical illness. We sought high-quality evidence in the form of systematic reviews containing meta-analyses of randomised controlled trials...
January 2010: Anaesthesia and Intensive Care
Paulo Filipe, Larry K Patterson, David M Bartels, Gordon L Hug, João P Freitas, Jean-Claude Mazière, René Santus, Patrice Morlière
In the minor fraction of HDL3 containing alpha-tocopherol (alphaTocOH), selective one-electron oxidation of Trp and Tyr residues of apolipoproteins A-I and A-II by *Br2- radical-anions produces the corresponding semioxidized species, TyrO* and *Trp. Repair of TyrO* by endogenous alphaTocOH generates the alpha-tocopheroxyl radical (alphaTocO*). Fast spectroscopic studies show that two populations representing 80% of alphaTocO* initially formed are repaired over several seconds with rate constants of 3.0 x 10(6) and 1...
December 11, 2007: Biochemistry
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