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Carcinoma oesophagus

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https://www.readbyqxmd.com/read/29774147/social-group-disparities-in-the-incidence-and-prognosis-of-oesophageal-cancer
#1
REVIEW
Shao-Hua Xie, Jesper Lagergren
There are substantial disparities in the incidence and prognosis of oesophageal cancer across social population groups, including sex, race/ethnicity, geographical location and socio-economic status. Both squamous cell carcinoma and adenocarcinoma of the oesophagus are more common in men than in women, but the male predominance in adenocarcinoma is stronger and less well understood. The varying incidence and prognosis of oesophageal cancer across racial/ethnic groups show distinct patterns by histological type...
April 2018: United European Gastroenterology Journal
https://www.readbyqxmd.com/read/29760376/the-novel-19q13-krab-zinc-finger-tumour-suppressor-znf382-is-frequently-methylated-in-oesophageal-squamous-cell-carcinoma-and-antagonises-wnt-%C3%AE-catenin-signalling
#2
Chong Zhang, Tingxiu Xiang, Shuman Li, Lin Ye, Yixiao Feng, Lijiao Pei, Lili Li, Xiangyu Wang, Ran Sun, Qian Tao, Guosheng Ren
Zinc finger proteins (ZFPs) are the largest transcription factor family in mammals. About one-third of ZFPs are Krüppel-associated box domain (KRAB)-ZFPs and involved in the regulation of cell differentiation/proliferation/apoptosis and neoplastic transformation. We recently identified ZNF382 as a novel KRAB-ZFP epigenetically inactivated in multiple cancers due to frequent promoter CpG methylation. However, its epigenetic alterations, biological functions/mechanism and clinical significance in oesophageal squamous cell carcinoma (ESCC) are still unknown...
May 14, 2018: Cell Death & Disease
https://www.readbyqxmd.com/read/29737322/robotic-assisted-minimally-invasive-oesophagectomy-for-cancer-an-initial-experience
#3
Chinnusamy Palanivelu, Sumanta Dey, Sandeep Sabnis, Raghavendra Gupta, Bharath Cumar, Saravana Kumar, Ramesh Natarajan, Parthasarathi Ramakrishnan
Background: The morbidity related to radical oesophagectomy can be reduced by adopting minimally invasive techniques. Over 250 thoraco-laparoscopic oesophagectomy (TLE) was done in our centre over the last 15 years, before adopting robotic surgery as the latest innovation in the field of minimally invasive surgery. Here, we share our initial experience of robotic-assisted minimally invasive oesophagectomy (RAMIE) for carcinoma oesophagus. Methods: A prospective observational study conducted from February to December 2017...
May 4, 2018: Journal of Minimal Access Surgery
https://www.readbyqxmd.com/read/29725274/her-2-protein-overexpression-in-patients-with-gastric-and-oesophageal-adenocarcinoma-at-a-tertiary-care-facility-in-ghana
#4
David Larbi Simpong, Richard Harry Asmah, Cecilia Krampah, Patrick Kafui Akakpo, Patrick Adu, Du-Bois Asante, Simon Naporo, Andrew Anthony Adjei, Richard Kwasi Gyasi
The prognosis of gastric and oesophageal adenocarcinoma remains generally poor. However, mounting evidence suggests a positive role of human epidermal growth factor receptor-2 (HER-2) expression in the prognosis of patients with these cancers. In this work, the patterns of HER-2 protein expression were determined in patients with gastric or oesophageal adenocarcinoma. Retrospectively, we reviewed records of gastric and oesophageal biopsies received from 2008 to 2012 and their corresponding archived formalin-fixed paraffin-embedded tissue blocks selected for immunohistochemical analysis...
2018: TheScientificWorldJournal
https://www.readbyqxmd.com/read/29708994/profiles-of-patient-and-tumour-characteristics-in-relation-to-health-related-quality-of-life-after-oesophageal-cancer-surgery
#5
Poorna Anandavadivelan, Anna Wikman, Asif Johar, Pernilla Lagergren
Strong deterioration in health-related quality of life (HRQOL) is a major concern in a sub-group of long-term oesophageal cancer survivors. This study aimed to identify potential clustering of patients and tumour variables that predicts such deterioration. Patient and tumour variables were collected in a prospective cohort of patients who underwent surgery for oesophageal cancer in Sweden 2001-2005. Latent cluster analysis identified statistically significant clustering of these variables. Multivariable logistic regression adjusted for age, BMI, tumour stage and marital status was used to determine odds ratios (ORs) with 95% confidence intervals (CIs) between patient profiles and HRQOL at 3 and 5 years from surgery...
2018: PloS One
https://www.readbyqxmd.com/read/29679113/increased-evidence-for-the-prognostic-value-of-fdg-uptake-on-late-treatment-pet-in-non-tumour-affected-oesophagus-in-irradiated-patients-with-oesophageal-carcinoma
#6
Yimin Li, Frank Hofheinz, Christian Furth, Chen Lili, Wu Hua, Pirus Ghadjar, Sebastian Zschaeck
PURPOSE: 18 F-FDG uptake in irradiated non-tumour-affected oesophagus (NTO) on restaging PET is a potential surrogate for the measurement of radiation-induced inflammation. Radiation-induced inflammation itself has been shown to be of high prognostic relevance in patients undergoing preoperative radiochemotherapy (RCT) for locally advanced oesophageal cancer. We assessed the prognostic relevance of FDG uptake in the NTO in an independent cohort of patients treated with definitive RCT...
April 21, 2018: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/29665326/towards-developing-a-meaningful-grading-system-for-cervical-squamous-cell-carcinoma
#7
W Glenn McCluggage
Cervical cancer is one of the commonest cancers worldwide, especially in developing countries. In early stage disease, a variety of pathological parameters are of prognostic value but currently this does not include tumour grade which, for a number of reasons, is of limited or no value in cervical squamous cell carcinomas. In a recent article in this journal, Jesinghaus and colleagues investigated a novel histopathological grading system based on tumour budding and cell nest size, which has been shown to outperform conventional grading systems for squamous cell carcinoma at several other sites such as lung, oral cavity, and oesophagus in terms of patient prognostication...
April 2018: Journal of Pathology. Clinical Research
https://www.readbyqxmd.com/read/29615371/intraluminal-brachytherapy-boost-following-external-beam-radiotherapy-with-concurrent-chemotherapy-of-oesophagus-carcinoma-results-of-a-prospective-observational-study
#8
P Nag, O P Gurjar, V Bhandari, K L Gupta, P Bagdare, H Goyal
PURPOSE: The main objective of our study is to evaluate response and toxicity profile in patients receiving external beam radiotherapy with concurrent chemotherapy followed by intraluminal brachytherapy boost for a carcinoma of the oesophagus. MATERIAL AND METHODS: Twenty patients with biopsy-proven carcinoma of the oesophagus received external beam radiotherapy (50Gy in 25 fractions) with concurrent chemotherapy (cisplatin: 40mg/m2 ). After a gap of two to three weeks, intraluminal brachytherapy (10Gy in two fractions each 1 week apart by a high dose rate60 Co source) was given...
March 31, 2018: Cancer Radiothérapie: Journal de la Société Française de Radiothérapie Oncologique
https://www.readbyqxmd.com/read/29573846/a-prospective-phase-i-ii-study-of-docetaxel-cisplatin-and-continuous-capecitabine-in-advanced-oesophago-gastric-cancer-nwcog-3
#9
S Gollins, S Massalha, A Mullard, R M Williams, A Lloyd, J Morris, A Garcia-Alonso
AIMS: This open-label prospective phase I/II dose-escalation study determined the maximum tolerated dose (MTD) and then evaluated response, safety and feasibility of a novel combination of docetaxel, cisplatinum and capecitabine (DCC) in chemotherapy-naive patients with advanced oesophago-gastric carcinoma. MATERIALS AND METHODS: Patients with adenocarcinoma or squamous cell carcinoma of the oesophagus or stomach, of good performance status, deemed too advanced for curative treatment, were given systematically increasing doses of 3 weekly DCC to ascertain the MTD...
March 21, 2018: Clinical Oncology: a Journal of the Royal College of Radiologists
https://www.readbyqxmd.com/read/29573787/tumour-motion-of-oesophageal-squamous-cell-carcinoma-evaluated-by-cine-mri-associated-with-tumour-location
#10
H-Y Zhou, J-G Zhang, R Li, X-M Zhang, T-W Chen, N Liu, Y Jiang, L Wu
AIM: To evaluate the association between oesophageal tumour motion and tumour location using cine magnetic resonance imaging (MRI). MATERIALS AND METHODS: Thirty-three consecutive patients with oesophageal squamous cell carcinoma were enrolled, and underwent cine MRI of oesophageal tumours. The maximum displacements in the anterior-posterior (A-P), superior-inferior (S-I), and left-right (L-R) directions of the tumours were assessed statistically to show their associations with tumour location...
March 21, 2018: Clinical Radiology
https://www.readbyqxmd.com/read/29563637/trends-and-projections-in-adenocarcinoma-and-squamous-cell-carcinoma-of-the-oesophagus-in-england-from-1971-to-2037
#11
Judith Offman, Francesca Pesola, Peter Sasieni
BACKGROUND: The aim of this study was to assess the incidence and trends of oesophageal adenocarcinomas (OACs) and squamous cell carcinomas (OSCCs) in England from 1971 to 2037. METHODS: Data on 220,026 oesophageal cancers diagnosed in England between 1971 and 2013 were extracted. Multiple imputation was used to predict morphology data were missing. Incidence rates were modelled and extrapolated to 2037 using age-period-cohort models. RESULTS: The OAC age-standardised incidence rate (ASRs) increase was greatest from 1972 to 1992 (from 4...
May 2018: British Journal of Cancer
https://www.readbyqxmd.com/read/29446982/development-of-an-omentum-cultured-oesophageal-scaffold-reinforced-by-a-3d-printed-ring-feasibility-of-an-in-vivo-bioreactor
#12
Eun-Jae Chung, Hyung Woo Ju, Yeung Kyu Yeon, Ji Seung Lee, Young Jin Lee, Ye Been Seo, Park Chan Hum
Current treatments of oesophageal diseases, such as carcinoma, congenital abnormality or trauma, require surgical intervention and oesophageal reconstruction with the stomach, jejunum or colon. However, serious side effects are possible with each treatment option. Despite tissue engineering promising to be an effective regenerative strategy, no functional solution currently exists for oesophageal reconstruction. Here, we developed an omentum-cultured oesophageal scaffold reinforced by a 3D-printed ring. The nano-structured scaffolds were wrapped into the omentum of rats and orthotopically transplanted for the repair of circumferential oesophageal defects two weeks later...
February 15, 2018: Artificial Cells, Nanomedicine, and Biotechnology
https://www.readbyqxmd.com/read/29402786/rigid-triple-endoscopy-improves-clinical-staging-of-primary-head-and-neck-cancer
#13
Shachi J Sharma, Jens J Linke, Tobias Kroll, Nora Wuerdemann, Jens P Klussmann, Orlando Guntinas-Lichius, Claus Wittekindt
BACKGROUND: Correct pre-therapeutic staging of the first primary carcinoma (FPC) and detection of simultaneous second primary carcinomas (SSPCs) decisively influence therapy and prognosis of head and neck squamous cell carcinomas (HNSCC). The aim of this study was to determine the benefit of pre-therapeutic triple endoscopy for detection of SSPC and pre-therapeutic T category. METHODS: A cohort of 234 HNSCC patients with completed triple endoscopy was reviewed, focusing on pre-therapeutic T category and SSPC...
2018: Oncology Research and Treatment
https://www.readbyqxmd.com/read/29300814/body-mass-index-and-20-specific-cancers-re-analyses-of-dose-response-meta-analyses-of-observational-studies
#14
E K Choi, H B Park, K H Lee, J H Park, M Eisenhut, H J van der Vliet, G Kim, J I Shin
Background: Objectives were to provide an overview and understand the strength of evidence and extent of potential biases and validity of claimed associations between body mass index (BMI) and risk of developing cancer. Methods: We carried out an umbrella review and comprehensively re-analyzed the data of dose-response meta-analyses on associations between BMI and risk of 20 specific cancers (bladder, brain, breast, colonic, rectal, endometrial, gallbladder, gastric, leukemia, liver, lung, melanoma, multiple myeloma, non-Hodgkins lymphoma, esophagus, ovarian, pancreatic, prostate, renal, thyroid) by adding big data or missed individual studies...
March 1, 2018: Annals of Oncology: Official Journal of the European Society for Medical Oncology
https://www.readbyqxmd.com/read/29275315/clinical-and-prognostic-analysis-of-hypopharyngeal-squamous-cell-carcinoma-with-synchronous-and-metachronous-multiple-malignancies
#15
Keisuke Yamamoto, Kenichi Takano, Atsushi Kondo, Makoto Kurose, Kazufumi Obata, Tetsuo Himi
BACKGROUND/AIM: To analyze the clinical features and prevalence of synchronous and metachronous second primary malignancies (SPMs) in patients with hypopharyngeal squamous cell carcinoma (HSCC), their associated risk factors, and cause-specific mortality. PATIENTS AND METHODS: We retrospectively reviewed 136 patients treated with curative intent at our hospital. Statistical analyses were performed to determine factors predictive of SPM and cause-specific mortality...
January 2018: In Vivo
https://www.readbyqxmd.com/read/29258858/emerging-biomarkers-for-immunomodulatory-cancer-treatment-of-upper-gastrointestinal-pancreatic-and-hepatic-cancers
#16
REVIEW
Belinda Lee, Ryan Hutchinson, Hui-Li Wong, Jeanne Tie, Tracy Putoczki, Ben Tran, Peter Gibbs, Michael Christie
Carcinomas of the oesophagus, stomach, pancreas and liver are common and account for a disproportionately high number of cancer deaths. There is a need for new treatment options for patients with advanced disease. Immunomodulatory treatments including immune checkpoint blockade offer a promising new approach, with efficacy shown in other solid tumour types. However, only a small proportion of patients with carcinomas of the oesophagus, stomach, pancreas and liver have responded to single agent checkpoint inhibitors, and there is a need for markers that are predictive of response to guide treatment of individual patients...
December 16, 2017: Seminars in Cancer Biology
https://www.readbyqxmd.com/read/29212656/the-relevance-and-implications-of-signet-ring-cell-adenocarcinoma-of-the-oesophagus
#17
REVIEW
Christopher William Bleaney, Mickhaiel Barrow, Stephen Hayes, Yeng Ang
AIM: To review the current understanding of signet-ring type oesophageal adenocarcinoma including evidence for prognosis. METHODS: We conducted a literature search of nine healthcare literature databases for articles detailing the biology and clinical outcomes of signet-ring cell adenocarcinoma of the oesophagus. The impact of signet-ring cell morphology was analysed and detailed in written text and tabular format. Current understanding of the biology of signet-ring cell adenocarcinoma of the oesophagus was summarised...
March 2018: Journal of Clinical Pathology
https://www.readbyqxmd.com/read/29201878/radiotherapy-treatment-strategies-for-squamous-cell-carcinoma-of-the-cervical-oesophagus-moving-toward-better-outcomes
#18
EDITORIAL
Pierfrancesco Franco, Francesca Arcadipane, Paolo Strignano, Renato Romagnoli, Umberto Ricardi
No abstract text is available yet for this article.
November 2017: Annals of Translational Medicine
https://www.readbyqxmd.com/read/29177066/non-acid-gastro-oesophageal-reflux-is-associated-with-squamous-cell-carcinoma-of-the-oesophagus
#19
Mpho Kgomo, Taole R Mokoena, James A Ker
Introduction: Squamous cell carcinoma of the oesophagus is a common cancer among South Africans. Due to the absence of effective screening and surveillance programme for early detection and late presentation, squamous cell carcinoma of the oesophagus is usually diagnosed at an advanced stage or when metastasis has already occurred. The 5-year survival is often quoted at 5%-10%, which is poor. Objectives: To determine the association between oesophageal squamous cell carcinoma (OSCC) and non-acid gastro-oesophageal reflux disease...
2017: BMJ Open Gastroenterology
https://www.readbyqxmd.com/read/29128908/a-phase-ii-study-evaluating-combined-neoadjuvant-cetuximab-and-chemotherapy-followed-by-chemoradiotherapy-and-concomitant-cetuximab-in-locoregional-oesophageal-cancer-patients
#20
Maria Alsina, Fernando Rivera, Francisco Javier Ramos, Maica Galán, Rafael López, Pilar García-Alfonso, José Enrique Alés-Martinez, Bernardo Queralt, Antonio Antón, Alfredo Carrato, Cristina Grávalos, Maria José Méndez-Vidal, Carlos López, Inmaculada Ruiz de Mena, Josep Tabernero, Jordi Giralt, Enrique Aranda
BACKGROUND: Pre-operative chemoradiotherapy using a 5-fluorouracil (5-FU)/cisplatin backbone is widely used to improve surgical outcomes in locoregional oesophageal cancer patients, despite a non-negligible failure rate. OBJECTIVE: We evaluated intensification of this approach to improve patient outcomes by adding cetuximab to induction 5-FU/cisplatin/docetaxel (TPF) and to chemoradiotherapy in a phase II study. PATIENTS AND METHODS: Between November 2006 and April 2009, 50 patients with stage II-IVa squamous cell carcinoma (SCC) or adenocarcinoma of the oesophagus or gastro-oesophageal junction initiated three TPF/cetuximab cycles...
February 2018: Targeted Oncology
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