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https://www.readbyqxmd.com/read/28323033/application-of-mathematical-models-to-metronomic-chemotherapy-what-can-be-inferred-from-minimal-parameterized-models
#1
Urszula Ledzewicz, Heinz Sch Attler
Metronomic chemotherapy refers to the frequent administration of chemotherapy at rela-tively low, minimally toxic doses without prolonged treatment interruptions. Different from conventional or maximum-tolerated-dose chemotherapy which aims at an eradication of all malignant cells, in a metronomic dosing the goal often lies in the long-term management of the disease when eradication proves elusive. Mathematical modeling and subsequent analysis (theoretical as well as numerical) have become an increasingly more valuable tool (in silico) both for determining conditions under which specific treatment strategies should be preferred and for numerically optimizing treatment regimens...
March 16, 2017: Cancer Letters
https://www.readbyqxmd.com/read/28298820/the-efficacy-of-transgingival-probing-in-class-ii-buccal-furcation-defects-treated-by-guided-tissue-regeneration
#2
Monika Bansal, Tej Bali Singh
BACKGROUND: The objectives of the present study were to establish transgingival probing as an evaluating method in the clinical studies of periodontal regenerative techniques and to compare the effectiveness of transgingival probing to the surgical entry. MATERIALS AND METHODS: Ten systemically healthy persons (20-50 years) with moderate to severe chronic periodontitis participated in this study. These cases were recruited into the study only when they fulfilled the eligibility criteria...
July 2016: Journal of Indian Society of Periodontology
https://www.readbyqxmd.com/read/28297312/anatomy-based-definition-of-point-a-utilizing-three-dimensional-volumetric-imaging-approach-for-high-dose-rate-hdr-intracavitary-brachytherapy-dose-prescription-when-treating-cervical-cancer-using-limited-resources
#3
Manish K Goyal, D V Rai, Than S Kehwar, Jayanand Manjhi, Bret H Heintz, Kathleen L Shide, Jerry L Barker
This study was designed to determine whether volumetric imaging could identify consistent alternative prescription methods to Manchester/point A when prescribing radiation dose in the treatment of cervical cancer using HDR intracavitary brachytherapy (ICBT). One hundred and twenty-five treatment plans of 25 patients treated for carcinoma of the cervix were reviewed retrospectively. Each patient received 5 fractions of HDR ICBT following initial cisplatin-based pelvic chemoradiation, and radiation dose was originally prescribed to point A (ICRU-38)...
November 2016: Journal of Applied Clinical Medical Physics
https://www.readbyqxmd.com/read/28291911/reproducibility-of-patient-setup-in-the-seated-treatment-position-a-novel-treatment-chair-design
#4
Rachel E McCarroll, Beth M Beadle, Danna Fullen, Peter A Balter, David S Followill, Francesco C Stingo, Jinzhong Yang, Laurence E Court
Radiotherapy in a seated position may be indicated for patients who are unable to lie on the treatment couch for the duration of treatment, in scenarios where a seated treatment position provides superior anatomical positioning and dose distributions, or for a low-cost system designed using a fixed treatment beam and rotating seated patient. In this study, we report a novel treatment chair that was constructed to allow for three-dimensional imaging and treatment delivery while ensuring robust immobilization, providing reproducibility equivalent to that in the traditional supine position...
January 2017: Journal of Applied Clinical Medical Physics
https://www.readbyqxmd.com/read/28280738/ultrasound-guided-obturator-nerve-block-a-focused-review-on-anatomy-and-updated-techniques
#5
REVIEW
Takayuki Yoshida, Tatsuo Nakamoto, Takahiko Kamibayashi
This review outlines the anatomy of the obturator nerve and the indications for obturator nerve block (ONB). Ultrasound-guided ONB techniques and unresolved issues regarding these procedures are also discussed. An ONB is performed to prevent thigh adductor jerk during transurethral resection of bladder tumor, provide analgesia for knee surgery, treat hip pain, and improve persistent hip adductor spasticity. Various ultrasound-guided ONB techniques can be used and can be classified according to whether the approach is distal or proximal...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28255617/immobile-cerebral-veins-in-the-context-of-positional-brain-shift-an-undescribed-risk-factor-for-acute-subdural-hemorrhage
#6
Satoshi Tsutsumi, Hideo Ono, Yukimasa Yasumoto
BACKGROUND: Changes in head position are thought to cause a degree of brain shift in the intracranial cavity. However, little is known on the concurrent shift of the cerebral veins. The present study aimed to investigate the positional shift of the cerebral veins that accompanies brain shift. METHODS: Sagittal T2-weighted magnetic resonance imaging was performed on 21 consecutive patients lying in the supine and prone positions, using the same sequence. For each patient, imaging data were obtained for the two positions as a pair of images with morphologically best-matched cerebral contours...
March 3, 2017: Surgical and Radiologic Anatomy: SRA
https://www.readbyqxmd.com/read/28229272/prophylactic-implantable-cardioverter-defibrillator-in-heart-failure-the-growing-evidence-for-all-or-primum-non-nocere-for-some
#7
REVIEW
Khang-Li Looi, Nigel Lever, Anthony Tang, Sharad Agarwal
Heart failure (HF) is a common health problem and has reached epidemic in many western countries. Despite the current era of HF treatment, the risk of sudden cardiac death (SCD) in HF remains significant. Implantable cardioverter defibrillator (ICD) support has been shown to reduce the risk of SCD in patients with HF and impaired left ventricular function. Prophylactic ICD implantation in HF patients seems a logical step to reduce mortality through a reduction in SCD. However, ICD implantation is an invasive procedure, and both short- and long-term complications can occur...
February 23, 2017: Heart Failure Reviews
https://www.readbyqxmd.com/read/28228938/physical-activity-levels-in-locally-advanced-rectal-cancer-patients-following-neoadjuvant-chemoradiotherapy-and-an-exercise-training-programme-before-surgery-a-pilot-study
#8
Lisa Loughney, Malcolm A West, Borislav D Dimitrov, Graham J Kemp, Michael Pw Grocott, Sandy Jack
BACKGROUND: The aim of this pilot study was to measure changes in physical activity level (PAL) variables, as well as sleep duration and efficiency in people with locally advanced rectal cancer (1) before and after neoadjuvant chemoradiotherapy (CRT) and (2) after participating in a pre-operative 6-week in-hospital exercise training programme, following neoadjuvant CRT prior to major surgery, compared to a usual care control group. METHODS: We prospectively studied 39 consecutive participants (27 males)...
2017: Perioperative Medicine
https://www.readbyqxmd.com/read/28224992/diagnostic-exome-sequencing-in-266-dutch-patients-with-visual-impairment
#9
Lonneke Haer-Wigman, Wendy Ag van Zelst-Stams, Rolph Pfundt, L Ingeborgh van den Born, Caroline Cw Klaver, Joke Bgm Verheij, Carel B Hoyng, Martijn H Breuning, Camiel Jf Boon, Anneke J Kievit, Virginie Jm Verhoeven, Jan Wr Pott, Suzanne Ceh Sallevelt, Johanna M van Hagen, Astrid S Plomp, Hester Y Kroes, Stefan H Lelieveld, Jayne Y Hehir-Kwa, Steven Castelein, Marcel Nelen, Hans Scheffer, Dorien Lugtenberg, Frans Pm Cremers, Lies Hoefsloot, Helger G Yntema
Inherited eye disorders have a large clinical and genetic heterogeneity, which makes genetic diagnosis cumbersome. An exome-sequencing approach was developed in which data analysis was divided into two steps: the vision gene panel and exome analysis. In the vision gene panel analysis, variants in genes known to cause inherited eye disorders were assessed for pathogenicity. If no causative variants were detected and when the patient consented, the entire exome data was analyzed. A total of 266 Dutch patients with different types of inherited eye disorders, including inherited retinal dystrophies, cataract, developmental eye disorders and optic atrophy, were investigated...
February 22, 2017: European Journal of Human Genetics: EJHG
https://www.readbyqxmd.com/read/28213194/subcortical-mapping-using-an-electrified-cusa-in-pediatric-supratentorial-surgery
#10
Jonathan Roth, Akiva Korn, Yifat Bitan-Talmor, Rivka Kaufman, Margaret Ekstein, Shlomi Constantini
BACKGROUND: Intraoperative electrophysiology is increasingly used for various lesion resections, both in adult and pediatric brain surgery. Subcortical mapping is often used in adult surgery when lesions lie in proximity to the corticospinal tract (CST). We describe a novel technique of continuous subcortical mapping using an electrified Cavitron UltraSonic Aspirator (CUSA) in children with supratentorial lesions. METHODS: We evaluated the method of subcortical mapping using a CUSA as a stimulation probe...
February 14, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28212433/elevated-gm3-plasma-concentration-in-idiopathic-parkinson-s-disease-a-lipidomic-analysis
#11
Robin B Chan, Adler J Perotte, Bowen Zhou, Christopher Liong, Evan J Shorr, Karen S Marder, Un J Kang, Cheryl H Waters, Oren A Levy, Yimeng Xu, Hong Bin Shim, Itsik Pe'er, Gilbert Di Paolo, Roy N Alcalay
Parkinson's disease (PD) is a common neurodegenerative disease whose pathological hallmark is the accumulation of intracellular α-synuclein aggregates in Lewy bodies. Lipid metabolism dysregulation may play a significant role in PD pathogenesis; however, large plasma lipidomic studies in PD are lacking. In the current study, we analyzed the lipidomic profile of plasma obtained from 150 idiopathic PD patients and 100 controls, taken from the 'Spot' study at Columbia University Medical Center in New York. Our mass spectrometry based analytical panel consisted of 520 lipid species from 39 lipid subclasses including all major classes of glycerophospholipids, sphingolipids, glycerolipids and sterols...
2017: PloS One
https://www.readbyqxmd.com/read/28209152/municipal-resources-and-patient-outcomes-through-the-first-year-after-a-hip-fracture
#12
Sabine Ruths, Valborg Baste, Marit Stordal Bakken, Lars Birger Engesæter, Stein Atle Lie, Siren Haugland
BACKGROUND: Hip fractures represent major critical events for older people, and put huge demands on economic and personnel resources. Most hip fracture patients are in need of postoperative rehabilitation services. Through the Coordination Reform, the municipalities in Norway were given increased responsibility for community-based treatment and rehabilitation after surgery. The purpose of this study was to examine associations between municipal resources and patient outcomes through the first year after a hip fracture, focusing on survival and health-related quality of life...
February 16, 2017: BMC Health Services Research
https://www.readbyqxmd.com/read/28168820/counter-intuitive-moral-judgement-following-traumatic-brain-injury
#13
Dane A Rowley, Miles Rogish, Timothy Alexander, Kevin J Riggs
Several neurological patient populations, including traumatic brain injury (TBI), appear to produce an abnormally 'utilitarian' pattern of judgements to moral dilemmas; they tend to make judgements that maximize the welfare of the majority, rather than deontological judgements based on the following of moral rules (e.g., do not harm others). However, this patient research has always used extreme dilemmas with highly valued moral rules (e.g., do not kill). Data from healthy participants, however, suggest that when a wider range of dilemmas are employed, involving less valued moral rules (e...
February 7, 2017: Journal of Neuropsychology
https://www.readbyqxmd.com/read/28166824/in-lab-versus-at-home-activity-recognition-in-ambulatory-subjects-with-incomplete-spinal-cord-injury
#14
Mark V Albert, Yohannes Azeze, Michael Courtois, Arun Jayaraman
BACKGROUND: Although commercially available activity trackers can aid in tracking therapy and recovery of patients, most devices perform poorly for patients with irregular movement patterns. Standard machine learning techniques can be applied on recorded accelerometer signals in order to classify the activities of ambulatory subjects with incomplete spinal cord injury in a way that is specific to this population and the location of the recording-at home or in the clinic. METHODS: Subjects were instructed to perform a standardized set of movements while wearing a waist-worn accelerometer in the clinic and at-home...
February 6, 2017: Journal of Neuroengineering and Rehabilitation
https://www.readbyqxmd.com/read/28159099/neurologic-diseases-and-sleep
#15
REVIEW
Daniel A Barone, Sudansu Chokroverty
Sleep disorders and neurologic illness are common and burdensome in their own right; when combined, they can have tremendous negative impact at an individual level as well as societally. The socioeconomic burden of sleep disorders and neurologic illness can be identified, but the real cost of these conditions lies far beyond the financial realm. There is an urgent need for comprehensive care and support systems to help with the burden of disease. Further research in improving patient outcomes in those who suffer with these conditions will help patients and their families, and society in general...
March 2017: Sleep Medicine Clinics
https://www.readbyqxmd.com/read/28154960/radiological-features-for-the-approach-in-trans-sphenoidal-pituitary-surgery
#16
Victoria Twigg, Simon D Carr, Ramkishan Balakumar, Saurabh Sinha, Showkat Mirza
INTRODUCTION: In order to perform trans-sphenoidal endoscopic pituitary surgery safely and efficiently it is important to identify anatomical and pituitary disease features on the pre-operative CT and MRI scans; thereby minimising the risk to surrounding structures and optimising outcomes. We aim to create a checklist to streamline pre-operative planning. METHODS: We retrospectively reviewed pre-operative CT and MRI scans of 100 adults undergoing trans-sphenoidal endoscopic pituitary surgery...
February 2, 2017: Pituitary
https://www.readbyqxmd.com/read/28150051/atypical-presentation-of-a-cervical-synovial-cyst
#17
Daniela Linhares, João Lobo, Rui Pinto, Nuno Neves
INTRODUCTION: Synovial cysts of the cervical spine are rare. These lesions have been associated with other spinal conditions as osteoarthritis, spondylolisthesis, and disc degeneration, with authors postulating a possible link with segmental spinal instability. This study aims to describe an atypically presenting case of a cervical synovial cyst. CASE REPORT: A 65-year-old man presented with complaints of cervical radicular pain (VAS of 7) that evolved with development of paresthesia and muscular weakness, compatible with C8 right compression...
February 1, 2017: European Spine Journal
https://www.readbyqxmd.com/read/28148207/clinical-cancer-advances-2017-annual-report-on-progress-against-cancer-from-the-american-society-of-clinical-oncology
#18
Harold J Burstein, Lada Krilov, Jeanny B Aragon-Ching, Nancy N Baxter, E Gabriela Chiorean, Warren Allen Chow, John Frederick De Groot, Steven Michael Devine, Steven G DuBois, Wafik S El-Deiry, Andrew S Epstein, John Heymach, Joshua Adam Jones, Deborah K Mayer, Rebecca A Miksad, Nathan A Pennell, Michael S Sabel, Richard L Schilsky, Lynn Mara Schuchter, Nadine Tung, Karen Marie Winkfield, Lori J Wirth, Don S Dizon
A MESSAGE FROM ASCO'S PRESIDENT I am pleased to present Clinical Cancer Advances 2017, which highlights the most promising advances in patient-oriented cancer research over the past year. The report gives us an opportunity to reflect on what an exciting time it is for cancer research and how swiftly our understanding of cancer has improved. One year ago, the White House announced the national Cancer Moonshot program to accelerate progress against cancer. This shared vision of progress has reinvigorated the research community, identified new areas of scientific collaboration, and raised our ambitions regarding what may be possible beyond the progress we have already made...
February 1, 2017: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/28134668/factors-predicting-pelvic-lymph-node-metastasis-relapse-and-disease-outcome-in-pattern-c-endocervical-adenocarcinomas
#19
Isabel Alvarado-Cabrero, Andres A Roma, Kay J Park, Joanne K L Rutgers, Elvio G Silva
A pattern-based classification system has recently been proposed for invasive endocervical adenocarcinoma (EAC), which is predictive of the risk for lymph node metastases (LNM). The main utility of the system lies in separating cases with very low risk for LNM (pattern A) from those with higher risk (pattern B and C). Different growth patterns (GPs) are found in pattern C cases. The aim of the study was to evaluate the effect of GP on the behavior of pattern C EAC. By reevaluating 189 pattern C EACs, we documented 6 architectural GPs: diffuse destructive (DD), confluent (CON), extensive linear destructive (ELD), band-like lymphocytic infiltrate (BLL), solid (SOL), and micropapillary (MP)...
January 27, 2017: International Journal of Gynecological Pathology
https://www.readbyqxmd.com/read/28113163/what-lies-within-the-human-body-might-well-be-one-of-the-best-sources-for-new-antibiotics
#20
Shannon Fischer
In 1991, a group of Italian researchers announced that they had isolated a new antibiotic from a chemical soup brewed with a soil-dwelling bacteria called Planobispora rosea. The drug was a type of thiopeptide, effective against grampositive bacteria like Staphylococcus aureus, P. acnes, and C. difficile but uncooperative in terms of being harnessed for human medicines. Little came of that work until around 2012, when pharma giant Novartis reported that it had begun to experiment with the original drug's structure, ultimately creating a semisynthetic version with enough solubility that it could be effectively administered to human patients...
September 2016: IEEE Pulse
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