keyword
https://read.qxmd.com/read/38531835/identifying-plasma-metabolic-characteristics-of-major-depressive-disorder-bipolar-disorder-and-schizophrenia-in-adolescents
#1
JOURNAL ARTICLE
Bangmin Yin, Yuping Cai, Teng Teng, Xiaolin Wang, Xueer Liu, Xuemei Li, Jie Wang, Hongyan Wu, Yuqian He, Fandong Ren, Tianzhang Kou, Zheng-Jiang Zhu, Xinyu Zhou
Major depressive disorder (MDD), bipolar disorder (BD), and schizophrenia (SCZ) are classified as major mental disorders and together account for the second-highest global disease burden, and half of these patients experience symptom onset in adolescence. Several studies have reported both similar and unique features regarding the risk factors and clinical symptoms of these three disorders. However, it is still unclear whether these disorders have similar or unique metabolic characteristics in adolescents. We conducted a metabolomics analysis of plasma samples from adolescent healthy controls (HCs) and patients with MDD, BD, and SCZ...
March 26, 2024: Translational Psychiatry
https://read.qxmd.com/read/38519416/effects-of-erythropoietin-on-cognitive-impairment-and-prefrontal-cortex-activity-across-affective-disorders-a-randomized-double-blinded-placebo-controlled-trial
#2
JOURNAL ARTICLE
Julian Macoveanu, Jeff Zarp Petersen, Johanna Mariegaard, Andreas Elleby Jespersen, Katrine Cramer, Caroline Fussing Bruun, Helle Østergaard Madsen, Martin Balslev Jørgensen, Maj Vinberg, Patrick M Fisher, Gitte Moos Knudsen, Ida Hageman, Hannelore Ehrenreich, Lars Vedel Kessing, Kamilla Woznica Miskowiak
BACKGROUND: Persistent cognitive impairment is frequent across bipolar disorder (BD) and major depressive disorder (MDD), highlighting an urgent need for pro-cognitive treatments. AIM: This study investigated effects of erythropoietin (EPO) on cognitive impairment and dorsal prefrontal cortex (dPFC) activity in affective disorders. METHODS: In this randomized, double-blinded, placebo-controlled trial, cognitively impaired patients with remitted BD or MDD received 1 weekly recombinant human EPO (40,000 IU/mL) or saline infusion for a 12-week period...
March 22, 2024: Journal of Psychopharmacology
https://read.qxmd.com/read/38515671/arginine-metabolomics-in-mood-disorders
#3
JOURNAL ARTICLE
Angelo Zinellu, Sara Tommasi, Stefania Sedda, Arduino A Mangoni
Alterations of nitric oxide (NO) homeostasis have been described in mood disorders. However, the analytical challenges associated with the direct measurement of NO have prompted the search for alternative biomarkers of NO synthesis. We investigated the published evidence of the association between these alternative biomarkers and mood disorders (depressive disorder or bipolar disorder). Electronic databases were searched from inception to the June 30, 2023. In 20 studies, there was a trend towards significantly higher asymmetric dimethylarginine (ADMA) in mood disorders vs...
March 30, 2024: Heliyon
https://read.qxmd.com/read/38510807/exploring-hub-genes-and-crucial-pathways-linked-to-oxidative-stress-in-bipolar-disorder-depressive-episodes-through-bioinformatics-analysis
#4
JOURNAL ARTICLE
Shasha Wu, Haiyang Hu, Yilin Li, Yan Ren
BACKGROUND: Bipolar disorder (BD) is a complex and serious psychiatric condition primarily characterized by bipolar depression, with the underlying genetic determinants yet to be elucidated. There is a substantial body of literature linking psychiatric disorders, including BD, to oxidative stress (OS). Consequently, this study aims to assess the relationship between BD and OS by identifying key hub genes implicated in OS pathways. METHODS: We acquired gene microarray data from GSE5392 through the Gene Expression Omnibus (GEO)...
2024: Frontiers in Psychiatry
https://read.qxmd.com/read/38505797/validating-the-efficacy-and-value-proposition-of-mental-fitness-vocal-biomarkers-in-a-psychiatric-population-prospective-cohort-study
#5
JOURNAL ARTICLE
Erik Larsen, Olivia Murton, Xinyu Song, Dale Joachim, Devon Watts, Flavio Kapczinski, Lindsey Venesky, Gerald Hurowitz
BACKGROUND: The utility of vocal biomarkers for mental health assessment has gained increasing attention. This study aims to further this line of research by introducing a novel vocal scoring system designed to provide mental fitness tracking insights to users in real-world settings. METHODS: A prospective cohort study with 104 outpatient psychiatric participants was conducted to validate the "Mental Fitness Vocal Biomarker" (MFVB) score. The MFVB score was derived from eight vocal features, selected based on literature review...
2024: Frontiers in Psychiatry
https://read.qxmd.com/read/38504593/the-emerging-neuroimmune-hypothesis-of-bipolar-disorder-an-updated-overview-of-neuroimmune-and-microglial-findings
#6
REVIEW
Adriano Chaves-Filho, Capri Eyres, Leonie Blöbaum, Antonia Landwehr, Marie-Ève Tremblay
Bipolar disorder (BD) is a severe and multifactorial disease, with onset usually in young adulthood, which follows a progressive course throughout life. Replicated epidemiological studies have suggested inflammatory mechanisms and neuroimmune risk factors as primary contributors to the onset and development of BD. While not all patients display overt markers of inflammation, significant evidence suggests that aberrant immune signaling contributes to all stages of the disease and seems to be mood phase dependent, likely explaining the heterogeneity of findings observed in this population...
March 19, 2024: Journal of Neurochemistry
https://read.qxmd.com/read/38503931/introducing-neurofilament-light-chain-measure-in-psychiatry-current-evidence-opportunities-and-pitfalls
#7
REVIEW
Francesco Bavato, Christian Barro, Laura K Schnider, Joel Simrén, Henrik Zetterberg, Erich Seifritz, Boris B Quednow
The recent introduction of new-generation immunoassay methods allows the reliable quantification of structural brain markers in peripheral matrices. Neurofilament light chain (NfL), a neuron-specific cytoskeletal component released in extracellular matrices after neuroaxonal impairment, is considered a promising blood marker of active brain pathology. Given its sensitivity to a wide range of neuropathological alterations, NfL has been suggested for the use in clinical practice as a highly sensitive, but unspecific tool to quantify active brain pathology...
March 19, 2024: Molecular Psychiatry
https://read.qxmd.com/read/38503928/associations-of-altered-leukocyte-ddr1-promoter-methylation-and-childhood-trauma-with-bipolar-disorder-and-suicidal-behavior-in-euthymic-patients
#8
JOURNAL ARTICLE
Beatriz Garcia-Ruiz, Esther Jiménez, Selena Aranda, Norma Verdolini, Alfonso Gutiérrez-Zotes, Cristina Sáez, Elisa Losantos, Silvia Alonso-Lana, Mar Fatjó-Vilas, Salvador Sarró, Llanos Torres, Francesco Panicalli, Caterina Del Mar Bonnin, Edith Pomarol-Clotet, Eduard Vieta, Elisabet Vilella
Altered DNA methylation (DNAm) patterns of discoidin domain receptor 1 (DDR1) have been found in the blood and brain of patients with schizophrenia (SCZ) and the brain of patients with bipolar disorder (BD). Childhood trauma (CT) is associated with changes in DNAm that in turn are related to suicidal behavior (SB) in patients with several psychiatric disorders. Here, using MassARRAY® technology, we studied 128 patients diagnosed with BD in remission and 141 healthy controls (HCs) to compare leukocyte DDR1 promoter DNAm patterns between patients and HCs and between patients with and without SB...
March 19, 2024: Molecular Psychiatry
https://read.qxmd.com/read/38499279/affective-disorders-and-the-loudness-dependence-of-the-auditory-evoked-potential-serotonin-and-beyond
#9
REVIEW
Paul J Fitzgerald
Identifying additional noninvasive biomarkers for affective disorders, such as unipolar major depressive disorder (MDD) and bipolar disorder (BD), could aid in the diagnosis and treatment of these prevalent and debilitating neuropsychiatric conditions. One such candidate biomarker is the loudness dependence of the auditory evoked potential (LDAEP), an event-related potential that measures responsiveness of the auditory cortex to different intensities of sound. The LDAEP has been associated with MDD and BD, including therapeutic response to particular classes of antidepressant drugs, while also correlating with several other neuropsychiatric disorders...
March 16, 2024: Neuroscience Letters
https://read.qxmd.com/read/38484669/olink-proteomics-analysis-uncovers-inflammatory-proteins-in-patients-with-different-states-of-bipolar-disorder
#10
JOURNAL ARTICLE
Fangming Xu, Yu Su, Xiaobo Wang, Tianle Zhang, Tingting Xie, Yumei Wang
STUDY DESIGN: A prospective study. BACKGROUND: This study aims to investigate the relationship between different states of bipolar disorder (BD) and plasma inflammatory proteins, which may be used as their biomarkers. MATERIALS AND METHODS: We totally collected admission plasma from 16 healthy subjects and 32 BD patients, including 16 patients with BD manic episodes (BD-M) and 16 patients with BD depressive episodes (BD-D). Ten samples in each group were analyzed by proximity extension assays of 92 inflammation-related proteins, and all samples were verified by ELISA...
March 13, 2024: International Immunopharmacology
https://read.qxmd.com/read/38482990/ligand-gated-ion-channels-as-potential-biomarkers-for-adt-mediated-cognitive-decline-in-prostate-cancer-patients
#11
JOURNAL ARTICLE
Shiv Verma, Vaibhav Singh, VijayKrishna Nagampalli, Lee E Ponsky, Chiang-Shan R Li, Herta Chao, Sanjay Gupta
Men with prostate cancer are at increased risk of developing cognitive decline by the use of second-generation androgen signaling inhibitors. To date, reliable and sensitive biomarkers that could distinguish men at high risk of cognitive dysfunction under androgen deprivation therapy (ADT) have not been characterized. We used high-throughput transcriptional profiling utilizing human prostate cancer cell culture models mimicking ADT, biomarker selection using minimal common oncology data elements-cytoscape, and bioinformatic analyses employing Advaita® iPathwayGuide and DisGeNET for identification of disease-related gene associations...
March 14, 2024: Molecular Carcinogenesis
https://read.qxmd.com/read/38470559/biomarkers-of-bipolar-disorder-in-late-life-an-evidence-based-systematic-review
#12
REVIEW
R Chancel, J Lopez-Castroman, E Baca-Garcia, R Mateos Alvarez, Ph Courtet, I Conejero
PURPOSE OF REVIEW: Review the current evidence on biomarkers for bipolar disorder in the older adults. We conducted a systematic search of PubMed MEDLINE, PsycINFO, and Web of Science databases using the MeSH search terms "Biomarkers", "Bipolar Disorder", "Aged" and and "Aged, 80 and over". Studies were included if they met the following criteria: (1) the mean age of the study population was 50 years old or older, (2) the study included patients with bipolar disorder, and (3) the study examined one type of biomarkers or more including genetic, neuroimaging, and biochemical biomarkers...
March 12, 2024: Current Psychiatry Reports
https://read.qxmd.com/read/38469291/brain-imaging-derived-phenotypes-a-biomarker-for-the-onset-of-inflammatory-bowel-disease-and-a-potential-mediator-of-mental-complications
#13
JOURNAL ARTICLE
Fan Li, Qi Zhao, Tongyu Tang, Yuyuan Liu, Zhaodi Wang, Zhi Wang, Xiaoping Han, Zifeng Xu, Yu Chang, Yuqin Li
BACKGROUND AND AIMS: Inflammatory bowel disease (IBD), mainly categorized into Crohn's disease (CD) and ulcerative colitis (UC), is a chronic relapsing gastrointestinal disorder that significantly impairs patients' quality of life. IBD patients often experience comorbidities such as anxiety and depression, and the underlying mechanisms and treatment strategies remain areas of investigation. METHODS: We conducted a Mendelian randomization(MR) analysis utilizing brain image derived phenotypes (IDP) from the UK Biobank database to investigate the causal relationships between IBD and alterations in brain structural morphology and connectivity of neural tracts...
2024: Frontiers in Immunology
https://read.qxmd.com/read/38442480/comparative-study-of-sleep-and-circadian-rhythms-in-patients-presenting-unipolar-or-bipolar-major-depressive-episodes
#14
JOURNAL ARTICLE
Jeanne Leseur, Charlotte Boiret, Alix Romier, Balthazar Bazin, Louise Basquin, Emilie Stern, Guillaume Pineau, Michel Lejoyeux, Pierre A Geoffroy, Julia Maruani
Currently, there is a major challenge in distinguishing between unipolar and bipolar major depressive episode. A significant body of research has been dedicated to identifying biomarkers that can aid in this differentiation due to its crucial implications, particularly for therapeutic and prognostic purposes. Among the biomarkers of interest, markers related to sleep and circadian rhythms show promise and could potentially aid in making this distinction. Nevertheless, no study has simultaneously examined sleep-wake disorders, circadian rhythms, and seasonal patterns using both subjective and objective measures...
February 20, 2024: Psychiatry Research
https://read.qxmd.com/read/38428239/abnormal-functional-connectivity-of-the-intrinsic-networks-in-adolescent-bipolar-i-versus-bipolar-ii-disorder
#15
JOURNAL ARTICLE
Qian Xiao, Gui Zhang, Yuan Zhong
BACKGROUND: The symptoms of pediatric bipolar disorder (PBD)-I and PBD-II differ, but accurate identification at an early stage is difficult and may prevent effective treatment of this disorder. Therefore, it is urgent to elucidate a biological marker based on objective imaging indicators to help distinguish the two. Therefore, this research aims to compare the functional connectivity between PBD-I patient and PBD-II patient in different brain networks. METHODS: Our study enrolled 31 PBD-I and 23 PBD-II patients from 12 to 17 years of age...
February 23, 2024: Psychiatry Research. Neuroimaging
https://read.qxmd.com/read/38412788/correlation-of-potential-diagnostic-biomarkers-circulating-mirna-and-protein-of-bipolar-ii-disorder
#16
JOURNAL ARTICLE
Kuo-Wang Tsai, Yi-Fang Yang, Liang-Jen Wang, Chih-Chuan Pan, Cheng-Ho Chang, Yung-Chih Chiang, Tzu-Yun Wang, Ru-Band Lu, Sheng-Yu Lee
OBJECTIVES: We previously identified certain peripheral biomarkers of bipolar II disorder (BD-II) including circulating miRNAs (miR-7-5p, miR-142-3p, miR-221-5p, and miR-370-3p) and proteins (Matrix metallopeptidase 9 (MMP9), phenylalanyl-tRNA synthetase subunit beta (FARSB), peroxiredoxin 2 (PRDX2), carbonic anhydrase 1 (CA-1), and proprotein convertase subtilisin/kexin type 9 (PCSK9)). We try to explore the connection between these biomarkers. METHODS: We explored correlations between the peripheral levels of above circulating miRNAs and proteins in our previously collected BD-II (N = 96) patients and control (N = 115) groups...
February 21, 2024: Journal of Psychiatric Research
https://read.qxmd.com/read/38396428/innovative-neuroimaging-biomarker-distinction-of-major-depressive-disorder-and-bipolar-disorder-through-structural-connectome-analysis-and-machine-learning-models
#17
JOURNAL ARTICLE
Yang Huang, Jingbo Zhang, Kewei He, Xue Mo, Renqiang Yu, Jing Min, Tong Zhu, Yunfeng Ma, Xiangqian He, Fajin Lv, Du Lei, Mengqi Liu
Major depressive disorder (MDD) and bipolar disorder (BD) share clinical features, which complicates their differentiation in clinical settings. This study proposes an innovative approach that integrates structural connectome analysis with machine learning models to discern individuals with MDD from individuals with BD. High-resolution MRI images were obtained from individuals diagnosed with MDD or BD and from HCs. Structural connectomes were constructed to represent the complex interplay of brain regions using advanced graph theory techniques...
February 10, 2024: Diagnostics
https://read.qxmd.com/read/38392971/lipids-in-psychiatric-disorders-functional-and-potential-diagnostic-role-as-blood-biomarkers
#18
REVIEW
Yana Zorkina, Valeria Ushakova, Aleksandra Ochneva, Anna Tsurina, Olga Abramova, Valeria Savenkova, Anna Goncharova, Irina Alekseenko, Irina Morozova, Daria Riabinina, Georgy Kostyuk, Anna Morozova
Lipids are a crucial component of the human brain, serving important structural and functional roles. They are involved in cell function, myelination of neuronal projections, neurotransmission, neural plasticity, energy metabolism, and neuroinflammation. Despite their significance, the role of lipids in the development of mental disorders has not been well understood. This review focused on the potential use of lipids as blood biomarkers for common mental illnesses, such as major depressive disorder, anxiety disorders, bipolar disorder, and schizophrenia...
January 23, 2024: Metabolites
https://read.qxmd.com/read/38377667/distinguishing-schizophrenia-and-bipolar-disorder-through-a-multiclass-classification-model-based-on-multimodal-neuroimaging-data
#19
JOURNAL ARTICLE
Ming Chen, Xiaowei Xia, Zhuang Kang, Zhinan Li, Jiamin Dai, Junyan Wu, Cai Chen, Yong Qiu, Tong Liu, Yanxi Liu, Ziyi Zhang, Qingni Shen, Sichu Tao, Zixin Deng, Ying Lin, Qinling Wei
This study aimed to identify neural biomarkers for schizophrenia (SZ) and bipolar disorder (BP) by analyzing multimodal neuroimaging. Utilizing data from structural magnetic resonance imaging (sMRI), diffusion tensor imaging (DTI), and resting-state functional magnetic resonance imaging (rs-fMRI), multiclass classification models were created for SZ, BP, and healthy controls (HC). A total of 113 participants (BP: 31, SZ: 39, and HC: 43) were recruited under strict enrollment control, from which 272, 200, and 1875 features were extracted from sMRI, DTI, and rs-fMRI data, respectively...
February 15, 2024: Journal of Psychiatric Research
https://read.qxmd.com/read/38371166/alterations-of-gastrointestinal-microbe-composition-in-various-human-diseases-and-its-significance-in-the-early-diagnosis-of-diseases
#20
REVIEW
Aman Agrawal, Ashish Anjankar
A 100 trillion bacteria, viruses, fungi, and archaea make up the human gut microbe. It has co-evolved with its human host and carries out essential tasks that improve general health. The relationship between gastrointestinal microbes and human health has been a growing field of interest and research in recent times. The gastrointestinal microbes are connected by complex networks and connections, and the host has given birth to the gut-microbe-brain axis, which shows the crucial effect that this circumstance could have on the health and diseases of the brain and spinal cord (or the central nervous system [CNS])...
January 2024: Curēus
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