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https://www.readbyqxmd.com/read/28419491/intrinsic-neural-activity-differences-among-psychotic-illnesses
#1
Matthew E Hudgens-Haney, Lauren E Ethridge, Justin B Knight, Jennifer E McDowell, Sarah K Keedy, Godfrey D Pearlson, Carol A Tamminga, Matcheri S Keshavan, John A Sweeney, Brett A Clementz
Individuals with psychosis have been reported to show either reduced or augmented brain responses under seemingly similar conditions. It is likely that inconsistent baseline-adjustment methods are partly responsible for this discrepancy. Using steady-state stimuli during a pro/antisaccade task, this study addressed the relationship between nonspecific and stimulus-related neural activity, and how these activities are modulated as a function of cognitive demands. In 98 psychosis probands (schizophrenia, schizoaffective disorder, and bipolar disorder with psychosis), neural activity was assessed during baseline and during a 5-s period in preparation for the pro/antisaccade task...
April 17, 2017: Psychophysiology
https://www.readbyqxmd.com/read/28415008/bipolar-mood-state-reflected-in-cortico-amygdala-resting-state-connectivity-a-cohort-and-longitudinal-study
#2
Roscoe O Brady, Allison Margolis, Grace A Masters, Matcheri Keshavan, Dost Öngür
BACKGROUND: Using resting-state functional magnetic resonance imaging (rsfMRI), we previously compared cohorts of bipolar I subjects in a manic state to those in a euthymic state to identify mood state-specific patterns of cortico-amygdala connectivity. Our results suggested that mania is reflected in the disruption of emotion regulation circuits. We sought to replicate this finding in a group of subjects with bipolar disorder imaged longitudinally across states of mania and euthymia METHODS: We divided our subjects into three groups: 26 subjects imaged in a manic state, 21 subjects imaged in a euthymic state, and 10 subjects imaged longitudinally across both mood states...
March 28, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/28386521/micrornas-as-biomarkers-for-psychiatric-conditions-a-review-of-current-research
#3
REVIEW
Anoop Narahari, Mariyah Hussain, Venkatesh Sreeram
Neural-derived exosomes can be used as diagnostic markers to screen for various psychiatric conditions. These intravenously injected exosomes carry the potential to cross the blood brain barrier and deliver miRNA molecules specifically to neurons, microglia, and oligodendrocytes in the brain, resulting in specific gene knockdown. Here the authors review and discuss the current research on microRNA molecules and the therapeutic roles they may potentially play in treating depression, bipolar disorder, and schizophrenia...
January 2017: Innovations in Clinical Neuroscience
https://www.readbyqxmd.com/read/28371745/homocysteine-as-a-peripheral-biomarker-in-bipolar-disorder-a-meta-analysis
#4
E Salagre, A F Vizuete, M Leite, D J Brownstein, A McGuinness, F Jacka, S Dodd, B Stubbs, C A Köhler, E Vieta, A F Carvalho, M Berk, B S Fernandes
BACKGROUND: Bipolar disorder (BD) is a psychiatric disorder with an uncertain aetiology. Recently, special attention has been given to homocysteine (Hcy), as it has been suggested that alterations in 1-carbon metabolism might be implicated in diverse psychiatric disorders. However, there is uncertainty regarding possible alterations in peripheral Hcy levels in BD. METHODS: This study comprises a meta-analysis comparing serum and plasma Hcy levels in persons with BD and healthy controls...
March 1, 2017: European Psychiatry: the Journal of the Association of European Psychiatrists
https://www.readbyqxmd.com/read/28345388/cortisol-levels-in-fingernails-neurocognitive-performance-and-clinical-variables-in-euthymic-bipolar-i-disorder
#5
Andres Herane-Vives, Anthony J Cleare, Chin-Kuo Chang, Valeria de Angel, Andrew Papadopoulos, Susanne Fischer, Rozmin Halari, Eric Y W Cheung, Allan H Young
OBJECTIVES: Neurocognitive impairment has been found in bipolar patients. Hypercortisolemia is one possible cause but there has been no agreement on this. Previous sampling methods assessed only acute cortisol levels, whereas the association between cortisol and psychopathology might be better understood by investigating chronic levels. Fingernails are a novel method for measuring chronic cortisol concentration (CCC). Here, we measured CCC in euthymic bipolar disorder I (BD-I) patients and healthy controls using fingernails to investigate whether differences in CCC influenced neurocognitive performance...
March 27, 2017: World Journal of Biological Psychiatry
https://www.readbyqxmd.com/read/28294459/identifying-dynamic-functional-connectivity-biomarkers-using-gig-ica-application-to-schizophrenia-schizoaffective-disorder-and-psychotic-bipolar-disorder
#6
Yuhui Du, Godfrey D Pearlson, Dongdong Lin, Jing Sui, Jiayu Chen, Mustafa Salman, Carol A Tamminga, Elena I Ivleva, John A Sweeney, Matcheri S Keshavan, Brett A Clementz, Juan Bustillo, Vince D Calhoun
Functional magnetic resonance imaging (fMRI) studies have shown altered brain dynamic functional connectivity (DFC) in mental disorders. Here, we aim to explore DFC across a spectrum of symptomatically-related disorders including bipolar disorder with psychosis (BPP), schizoaffective disorder (SAD), and schizophrenia (SZ). We introduce a group information guided independent component analysis procedure to estimate both group-level and subject-specific connectivity states from DFC. Using resting-state fMRI data of 238 healthy controls (HCs), 140 BPP, 132 SAD, and 113 SZ patients, we identified measures differentiating groups from the whole-brain DFC and traditional static functional connectivity (SFC), separately...
May 2017: Human Brain Mapping
https://www.readbyqxmd.com/read/28291257/integrated-transcriptome-and-methylome-analysis-in-youth-at-high-risk-for-bipolar-disorder-a-preliminary-analysis
#7
G R Fries, J Quevedo, C P Zeni, I F Kazimi, G Zunta-Soares, D E Spiker, C L Bowden, C Walss-Bass, J C Soares
First-degree relatives of patients with bipolar disorder (BD), particularly their offspring, have a higher risk of developing BD and other mental illnesses than the general population. However, the biological mechanisms underlying this increased risk are still unknown, particularly because most of the studies so far have been conducted in chronically ill adults and not in unaffected youth at high risk. In this preliminary study we analyzed genome-wide expression and methylation levels in peripheral blood mononuclear cells from children and adolescents from three matched groups: BD patients, unaffected offspring of bipolar parents (high risk) and controls (low risk)...
March 14, 2017: Translational Psychiatry
https://www.readbyqxmd.com/read/28264765/a-functional-connectivity-comparison-between-attention-deficit-hyperactivity-disorder-and-bipolar-disorder-in-medication-na%C3%A3-ve-adolescents-with-mood-fluctuation-and-attention-problems
#8
Young Don Son, Doug Hyun Han, Sun Mi Kim, Kyung Joon Min, Perry F Renshaw
In order to compare patterns of connectivity between affective and attention networks in adolescents with bipolar disorder (BD) and attention deficit hyperactivity disorder (ADHD), we investigated differences in resting state functional connectivity (RSFC) between these populations. Study participants were medication-naïve adolescents (aged 13-18 years) with BD (N=22) or ADHD (N=25) and age- and sex-matched healthy adolescents (healthy controls [HC]) (N=22). Forty-seven adolescents with mood fluctuation and attention problems showed increased functional correlation (FC) between two pairs of regions within the affective network (AFN), compared to 22 HC: the left orbitofrontal cortex (OFC) to the left thalamus and the left OFC to the right thalamus...
February 17, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/28230325/serum-phosphatidylinositol-as-a-biomarker-for-bipolar-disorder-liability
#9
Emma Em Knowles, Peter J Meikle, Kevin Huynh, Harald Hh Göring, Rene L Olvera, Samuel R Mathias, Ravi Duggirala, Laura Almasy, John Blangero, Joanne E Curran, David C Glahn
OBJECTIVES: Individuals with bipolar disorder (BPD) exhibit alterations in their phospholipid levels. It is unclear whether these alterations are a secondary consequence of illness state, or if phospholipids and illness risk overlap genetically. If the latter were true, then phospholipids might provide key insights into the pathophysiology of the illness. Therefore, we rank-ordered phospholipid classes by their genetic overlap with BPD risk in order to establish which class might be most informative in terms of increasing our understanding of illness pathophysiology...
February 23, 2017: Bipolar Disorders
https://www.readbyqxmd.com/read/28225367/progranulin-gene-variation-affects-serum-progranulin-levels-differently-in-danish-bipolar-individuals-compared-with-healthy-controls
#10
Henriette N Buttenschøn, Marit N Nielsen, Gangadaar Thotakura, Chris W Lee, Anders Nykjær, Ole Mors, Simon Glerup
OBJECTIVES: The identification of peripheral biomarkers for bipolar disorder is of great importance and has the potential to improve diagnosis, treatment and prognosis. Recent studies have reported lower plasma progranulin levels in bipolar individuals compared with controls and association with single nucleotide polymorphisms (SNPs) within the progranulin gene (GRN). In the present study, we investigated the effect of GRN and sortilin (SORT1) gene variation on serum progranulin levels in bipolar individuals and controls...
February 20, 2017: Psychiatric Genetics
https://www.readbyqxmd.com/read/28205606/differential-abnormal-pattern-of-anterior-cingulate-gyrus-activation-in-unipolar-and-bipolar-depression-an-fmri-and-pattern-classification-approach
#11
Christian Bürger, Ronny Redlich, Dominik Grotegerd, Susanne Meinert, Katharina Dohm, Ilona Schneider, Dario Zaremba, Katharina Förster, Judith Alferink, Jens Bölte, Walter Heindel, Harald Kugel, Volker Arolt, Udo Dannlowski
Distinguishing bipolar disorder from major depressive disorder is a major challenge in psychiatric treatment. Consequently, there has been growing interest in identifying neuronal biomarkers of disorder-specific pathophysiological processes to differentiate affective disorders. Thirty-six depressed bipolar patients, 36 depressed unipolar patients and 36 matched healthy controls participated in an fMRI-experiment. Emotional faces served as stimuli in a matching task. We investigated neural activation towards angry, fearful and happy faces focusing on prototypical regions related to emotion processing, ie the amygdala and the anterior cingulate gyrus (ACG)...
February 16, 2017: Neuropsychopharmacology: Official Publication of the American College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/28199074/inflammatory-markers-and-brain-derived-neurotrophic-factor-as-potential-bridges-linking-bipolar-disorder-and-cardiovascular-risk-among-adolescents
#12
Jessica K Hatch, Gustavo Scola, Omodele Olowoyeye, Jordan E Collins, Ana C Andreazza, Alan Moody, Anthony J Levitt, Bradley H Strauss, Krista L Lanctot, Benjamin I Goldstein
OBJECTIVE: Bipolar disorder (BD) is associated with increased rates of cardiovascular disease (CVD). Brain-derived neurotrophic factor (BDNF) and inflammatory markers are leading biomarkers in BD. We examined whether these biomarkers underlie the link between BD and CVD proxies among adolescents with bipolar spectrum disorders. METHODS: Subjects were 60 adolescents, 13-19 years old (40 with BD and 20 healthy controls [HCs]). Semistructured interviews determined diagnoses based on DSM-IV...
February 14, 2017: Journal of Clinical Psychiatry
https://www.readbyqxmd.com/read/28186315/sleep-study-in-disruptive-mood-dysregulation-disorder-and-bipolar-children
#13
Xavier Estrada-Prat, Ion Álvarez-Guerrico, María J Bleda-Hernández, Ester Camprodon-Rosanas, Santiago Batlle-Vila, Elena Pujals-Altes, María T Nascimento-Osorio, Luís M Martín-López, Enric Álvarez-Martínez, Víctor Pérez-Solá, Soledad Romero-Cela
INTRODUCTION: Decreased need for sleep has been proposed as a core symptom of mania and it has been associated with the pathogenesis of Bipolar Disorder. The emergence of Disruptive Mood Dysregulation Disorder (DMDD) as a new diagnostic has been controversial and much has been speculated about its relationship with the bipolar spectrum. REM sleep fragmentation could be a biomarker of affective disorders and it would help us to differentiate them from other disorders. METHOD: Polysomnographic cross-sectional study of children with DMDD, bipolar disorder and Attention Deficit Hyperactivity Disorder (ADHD)...
January 2017: Actas Españolas de Psiquiatría
https://www.readbyqxmd.com/read/28159382/the-putative-role-of-neuronal-network-synchronization-as-a-potential-biomarker-for-bipolar-disorder-a-review-of-eeg-studies
#14
REVIEW
E Maggioni, A M Bianchi, A C Altamura, Jair C Soares, P Brambilla
Impaired intra-hemispheric and inter-hemispheric communication play a major role in the pathophysiology and cognitive disturbances of bipolar disorder (BD). Brain connectivity in BD has been largely investigated using magnetic resonance imaging (MRI) techniques, which have found alterations in prefronto-limbic coupling. In contrast, evidence for functional neural circuitry abnormalities in BD is less consistent. Indeed, just a few studies employing the electroencephalographic (EEG) technique, enabling the exploration of oscillatory brain dynamics, addressed this issue...
January 3, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/28108228/a-preliminary-study-of-endocannabinoid-system-regulation-in-psychosis-distinct-alterations-of-cnr1-promoter-dna-methylation-in-patients-with-schizophrenia
#15
Claudio D'Addario, Vincenzo Micale, Martina Di Bartolomeo, Tibor Stark, Mariangela Pucci, Alexandra Sulcova, Mariacarlotta Palazzo, Zuzana Babinska, Laura Cremaschi, Filippo Drago, A Carlo Altamura, Mauro Maccarrone, Bernardo Dell'Osso
Compelling evidence supports the involvement of the endocannabinoid system (ECS) in psychosis vulnerability. We here evaluated the transcriptional regulation of ECS components in human peripheral blood mononuclear cells (PBMCs) obtained from subjects suffering from bipolar disorder, major depressive disorder and schizophrenia, focusing in particular on the effects of DNA methylation. We observed selective alterations of DNA methylation at the promoter of CNR1, the gene coding for the type-1 cannabinoid receptor, in schizophrenic patients (N=25) with no changes in any other disorder...
January 17, 2017: Schizophrenia Research
https://www.readbyqxmd.com/read/28088747/decreased-s100b-serum-levels-after-treatment-in-bipolar-patients-in-a-manic-phase
#16
Meng-Chang Tsai, Tiao-Lai Huang
BACKGROUND: Previous studies have suggested that patients with bipolar disorder might have brain damage. The aim of this study was to investigate the serum levels of brain injury biomarkers and S100A10 in bipolar patients in a manic phase, and evaluate the changes in S100B, neuron specific enolase (NSE), heat shock protein 70 (HSP70) and S100A10 after treatment. METHOD: We consecutively enrolled 17 bipolar inpatients in a manic phase and 30 healthy subjects. Serum brain injury biomarkers and S100A10 were measured with assay kits...
January 3, 2017: Comprehensive Psychiatry
https://www.readbyqxmd.com/read/28077175/structural-correlates-of-trait-impulsivity-in-patients-with-bipolar-disorder-and-healthy-controls-a-surface-based-morphometry-study
#17
P C Tu, Y H Kuan, C T Li, T P Su
BACKGROUND: Patients with bipolar disorder (BD) frequently exhibit impulsive behaviors independent of their mood state, and trait impulsivity is increasingly recognized as a crucial BD biomarker. This study aimed to investigate structural correlates of trait impulsivity measured using the Barratt Impulsiveness Scale (BIS) in healthy controls (HCs) and patients with BD. METHOD: We recruited 59 patients diagnosed with BD I or BD II (35.3 ± 8.5 years) and 56 age- and sex-matched HCs (33...
January 12, 2017: Psychological Medicine
https://www.readbyqxmd.com/read/28049075/abnormal-brain-oscillations-persist-after-recovery-from-bipolar-depression
#18
P Canali, S Casarotto, M Rosanova, G Sferrazza-Papa, A G Casali, O Gosseries, M Massimini, E Smeraldi, C Colombo, F Benedetti
When directly perturbed in healthy subjects, premotor cortical areas generate electrical oscillations in the beta range (20-40Hz). In schizophrenia, major depressive disorder and bipolar disorder (BD), these oscillations are markedly reduced, in terms of amplitude and frequency. However, it still remains unclear whether these abnormalities can be modulated over time, or if they can be still observed after treatment. Here, we employed transcranial magnetic stimulation (TMS) combined with EEG to assess the frontal oscillatory activity in eighteen BD patients before/after antidepressant treatments (sleep deprivation and light therapy), relative to nine healthy controls...
March 2017: European Psychiatry: the Journal of the Association of European Psychiatrists
https://www.readbyqxmd.com/read/28030612/distinct-and-shared-endophenotypes-of-neural-substrates-in-bipolar-and-major-depressive-disorders
#19
Toshio Matsubara, Koji Matsuo, Kenichiro Harada, Masayuki Nakano, Mami Nakashima, Toshio Watanuki, Kazuteru Egashira, Matakazu Furukawa, Naofumi Matsunaga, Yoshifumi Watanabe
Little is known about disorder-specific biomarkers of bipolar disorder (BD) and major depressive disorder (MDD). Our aim was to determine a neural substrate that could be used to distinguish BD from MDD. Our study included a BD group (10 patients with BD, 10 first-degree relatives (FDRs) of individuals with BD), MDD group (17 patients with MDD, 17 FDRs of individuals with MDD), and 27 healthy individuals. Structural and functional brain abnormalities were evaluated by voxel-based morphometry and a trail making test (TMT), respectively...
2016: PloS One
https://www.readbyqxmd.com/read/27996307/clock-genes-associate-with-white-matter-integrity-in-depressed-bipolar-patients
#20
Irene Bollettini, Elisa Maria Teresa Melloni, Veronica Aggio, Sara Poletti, Cristina Lorenzi, Adele Pirovano, Benedetta Vai, Sara Dallaspezia, Cristina Colombo, Francesco Benedetti
Human genetic studies have implicated specific genes that constitute the molecular clock in the manifestation of bipolar disorder (BD). Among the clock genes involved in the control system of circadian rhythms, CLOCK 3111 T/C and Period3 (PER3) influence core psychopathological features of mood disorders, such as patterns of sleep, rest, and activity, diurnal preference, cognitive performances after sleep loss, age at the onset of the illness, and response to antidepressant treatment. Furthermore, several studies pointed out that bipolar symptomatology is associated with dysfunctions in white matter (WM) integrity, suggesting these structural alterations as a possible biomarker of the disorder...
2017: Chronobiology International
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