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bipolar disorder biomarkers

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https://www.readbyqxmd.com/read/28986182/on-the-transdiagnostic-nature-of-peripheral-biomarkers-in-major-psychiatric-disorders-a-systematic-review
#1
REVIEW
Jairo Vinícius Pinto, Thiago C Moulin, Olavo B Amaral
The search for biomarkers has been a leading endeavor in biological psychiatry. To analyze its evolution over the years, we performed a systematic review to evaluate (a) the most studied peripheral molecular markers in major psychiatric disorders, (b) the main features of studies proposing them as biomarkers and (c) whether their patterns of variation are similar across disorders. Of the six molecules most commonly studied as plasmatic markers of schizophrenia, major depressive disorder or bipolar disorder, five (BDNF, TNF-alpha, IL-6, C-reactive protein and cortisol) were the same across diagnoses...
October 3, 2017: Neuroscience and Biobehavioral Reviews
https://www.readbyqxmd.com/read/28969861/the-mirnome-of-bipolar-disorder
#2
REVIEW
Gabriel R Fries, Andre F Carvalho, Joao Quevedo
BACKGROUND: Epigenetic mechanisms have been suggested to play a key role in the pathophysiology of bipolar disorder (BD), among which microRNAs (miRNAs) may be of particular significance according to recent studies. We aimed to summarize miRNA studies in BD to identify consistent findings, limitations, and future directions of this emerging field. METHODS: We performed a comprehensive search on PUBMED and Medline for studies investigating an association between BD and miRNAs...
September 23, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/28968199/meta-analysis-of-central-and-peripheral-%C3%AE-aminobutyric-acid-levels-in-patients-with-unipolar-and-bipolar-depression
#3
Bruno Romeo, Walid Choucha, Philippe Fossati, Jean-Yves Rotge
BACKGROUND: Many studies have measured central and peripheral γ-aminobutyric acid (GABA) levels in patients with depression. We performed a meta-analysis to provide an objective overview of GABA changes in those with unipolar or bipolar depression. METHODS: After a systematic database search, original data were extracted with the help of seminal authors to calculate standardized mean differences. We compared GABA levels between patients with current major depressive episodes and controls, between euthymic patients and controls, and in patients before and after treatment...
October 2, 2017: Journal of Psychiatry & Neuroscience: JPN
https://www.readbyqxmd.com/read/28960527/diffusion-entropy-a-potential-neuroimaging-biomarker-of-bipolar-disorder-in-the-temporal-pole
#4
Karl Spuhler, Elizabeth Bartlett, Jie Ding, Christine DeLorenzo, Ramin Parsey, Chuan Huang
Despite much research, bipolar depression remains poorly understood, with no clinically useful biomarkers for its diagnosis. The paralimbic system has become a target for biomarker research, with paralimbic structural connectivity commonly reported to distinguish bipolar patients from controls in tractography-based diffusion MRI studies, despite inconsistent findings in voxel-based studies. The purpose of this analysis was to validate existing findings with traditional diffusion MRI metrics and investigate the utility of a novel diffusion MRI metric, entropy of diffusion, in the search for bipolar depression biomarkers...
September 28, 2017: Synapse
https://www.readbyqxmd.com/read/28944987/the-international-society-for-bipolar-disorders-task-force-report-on-pediatric-bipolar-disorder-knowledge-to-date-and-directions-for-future-research
#5
REVIEW
Benjamin I Goldstein, Boris Birmaher, Gabrielle A Carlson, Melissa P DelBello, Robert L Findling, Mary Fristad, Robert A Kowatch, David J Miklowitz, Fabiano G Nery, Guillermo Perez-Algorta, Anna Van Meter, Cristian P Zeni, Christoph U Correll, Hyo-Won Kim, Janet Wozniak, Kiki D Chang, Manon Hillegers, Eric A Youngstrom
OBJECTIVES: Over the past two decades, there has been tremendous growth in research regarding bipolar disorder (BD) among children and adolescents (ie, pediatric BD [PBD]). The primary purpose of this article is to distill the extant literature, dispel myths or exaggerated assertions in the field, and disseminate clinically relevant findings. METHODS: An international group of experts completed a selective review of the literature, emphasizing areas of consensus, identifying limitations and gaps in the literature, and highlighting future directions to mitigate these gaps...
September 25, 2017: Bipolar Disorders
https://www.readbyqxmd.com/read/28929992/mood-disorders-and-circulating-levels-of-inflammatory-markers-in-a-longitudinal-population-based-study
#6
J Glaus, R von Känel, A M Lasserre, M-P F Strippoli, C L Vandeleur, E Castelao, M Gholam-Rezaee, C Marangoni, E-Y N Wagner, P Marques-Vidal, G Waeber, P Vollenweider, M Preisig, K R Merikangas
BACKGROUND: There has been increasing evidence that chronic low-grade inflammation is associated with mood disorders. However, the findings have been inconsistent because of heterogeneity across studies and methodological limitations. Our aim is to prospectively evaluate the bi-directional associations between inflammatory markers including interleukin (IL)-6, tumor necrosis factor (TNF)-α and high sensitivity C-reactive protein (hsCRP) with mood disorders. METHODS: The sample consisted of 3118 participants (53...
September 20, 2017: Psychological Medicine
https://www.readbyqxmd.com/read/28910601/identification-of-plasma-biomarkers-for-distinguishing-bipolar-depression-from-major-depressive-disorder-by-itraq-coupled-lc-ms-ms-and-bioinformatics-analysis
#7
Juanjuan Ren, Guoqing Zhao, Xiujia Sun, Hongmei Liu, Ping Jiang, Jun Chen, Zhiguo Wu, Daihui Peng, Yiru Fang, Chen Zhang
It is important to differentiate between bipolar disorder (BD) and major depressive disorder (MDD) in the first depressive episode because of the potential treatment implications. Previous studies have mainly focused on the different clinical features or pathological biomarkers to distinguish these two diseases; however, a better understanding of the proteomics profiling of BD may help aid future therapeutic strategies. Here, we applied isobaric tags for relative and absolute quantification (iTRAQ) technology combined with liquid chromatography-tandem mass spectrometry (LC-MS/MS) to identify differentially expressed proteins between MDD and bipolar depression (BP)...
September 5, 2017: Psychoneuroendocrinology
https://www.readbyqxmd.com/read/28895492/low-cardiac-vagal-tone-index-by-heart-rate-variability-differentiates-bipolar-from-major-depression
#8
Brandon Hage, Briana Britton, David Daniels, Keri Heilman, Stephen W Porges, Angelos Halaris
OBJECTIVES: Major depressive disorder (MDD) and depression in bipolar disorder (BD) are often difficult to distinguish from each other. Autonomic nervous system (ANS) dysregulation is associated with various depressive symptoms and inflammatory response disinhibition. The beat-to-beat pattern of heart rate (Heart Rate Variability) (HRV) offers a noninvasive portal to ANS function and provides a reliable index of resting cardiac vagal tone. We quantified HRV and measured inflammatory biomarkers in MDD and BD patients in an effort to derive potential diagnostic criteria for MDD and BD...
September 12, 2017: World Journal of Biological Psychiatry
https://www.readbyqxmd.com/read/28892068/dysregulation-of-objectively-assessed-24-hour-motor-activity-patterns-as-a-potential-marker-for-bipolar-i-disorder-results-of-a-community-based-family-study
#9
H Shou, L Cui, I Hickie, D Lameira, F Lamers, J Zhang, C Crainiceanu, V Zipunnikov, K R Merikangas
There has been a growing number of studies that have employed actigraphy to investigate differences in motor activity in mood disorders. In general, these studies have shown that people with bipolar disorders (BPDs) tend to exhibit greater variability and less daytime motor activity than controls. The goal of this study was to examine whether patterns of motor activity differ in euthymic individuals across the full range of mood disorder subtypes (Bipolar I (BPI), Bipolar II (BPII) and major depression (MDD)) compared with unaffected controls in a community-based family study of mood spectrum disorders...
August 22, 2017: Translational Psychiatry
https://www.readbyqxmd.com/read/28867391/are-there-differences-in-lipid-peroxidation-and-immune-biomarkers-between-major-depression-and-bipolar-disorder-effects-of-melancholia-atypical-depression-severity-of-illness-episode-number-suicidal-ideation-and-prior-suicide-attempts
#10
Magdalena Sowa-Kućma, Krzysztof Styczeń, Marcin Siwek, Paulina Misztak, Rafał J Nowak, Dominika Dudek, Janusz K Rybakowski, Gabriel Nowak, Michael Maes
BACKGROUND: There is evidence that major depression (MDD) and bipolar disorder (BD) are accompanied by activated immune & oxidative (I&O) pathways. METHODS: To compare I&O biomarkers between MDD and BD we assessed serum levels of thiobarbituric acid reactive substances (TBARS; a lipid peroxidation marker), soluble interleukin-2 receptor (sIL-2R), sIL-6R, IL-α, sIL-1R antagonist (sIL-1RA), tumor necrosis factor receptor 60kDa/80kDa (sTNFR60/R80) in 114 MDD and 133 BD patients, and 50 healthy controls...
September 1, 2017: Progress in Neuro-psychopharmacology & Biological Psychiatry
https://www.readbyqxmd.com/read/28864122/biological-aspects-and-candidate-biomarkers-for-rapid-cycling-in-bipolar-disorder-a-systematic-review
#11
REVIEW
Massimiliano Buoli, Marta Serati, A Carlo Altamura
Rapid-cycling bipolar disorder represents a frequent severe subtype of illness which has been associated with poor response to pharmacological treatment. Aim of the present article is to provide an updated review of biological markers associated with rapid-cycling bipolar disorder. A research in the main database sources has been conducted to identify relevant papers about the topic. Rapid-cycling bipolar disorder patients seem to have a more frequent family history for bipolar spectrum disorders (d range: 0...
August 24, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/28861763/prediction-of-vulnerability-to-bipolar-disorder-using-multivariate-neurocognitive-patterns-a-pilot-study
#12
Mon-Ju Wu, Benson Mwangi, Ives Cavalcante Passos, Isabelle E Bauer, Bo Cao, Thomas W Frazier, Giovana B Zunta-Soares, Jair C Soares
Bipolar disorder (BD) is a common disorder with high reoccurrence rate in general population. It is critical to have objective biomarkers to identify BD patients at an individual level. Neurocognitive signatures including affective Go/No-go task and Cambridge Gambling task showed the potential to distinguish BD patients from health controls as well as identify individual siblings of BD patients. Moreover, these neurocognitive signatures showed the ability to be replicated at two independent cohorts which indicates the possibility for generalization...
September 1, 2017: International Journal of Bipolar Disorders
https://www.readbyqxmd.com/read/28861306/the-predictive-value-of-platelet-to-lymphocyte-and-neutrophil-to-lymphocyte-ratio-in-determining-urethral-stricture-after-transurethral-resection-of-prostate
#13
Murat Gül, Emre Altıntaş, Mehmet Kaynar, Muhammet Serdar Buğday, Serdar Göktaş
OBJECTIVE: The pathology of urethral stricture disease is still unclear however progressive inflammation may contribute to the development of urethral stricture. The platelet-to- lymphocyte ratio (PLR) is a new and simple marker that indicates inflammation. In this study we aimed to investigate the predictive value of neutrophil to lymphocyte ratio (NLR) and PLR in patients with urethral stricture who underwent transurethral resection of prostate (TURP). MATERIAL AND METHODS: A total of 208 patients who underwent bipolar-TURP were included in this study...
September 2017: Turkish Journal of Urology
https://www.readbyqxmd.com/read/28854847/rna-sequencing-of-bipolar-disorder-lymphoblastoid-cell-lines-implicates-the-neurotrophic-factor-hrp-3-in-lithium-s-clinical-efficacy
#14
Elena Milanesi, Irena Voinsky, Adva Hadar, Ala Srouji, Carlo Maj, Tatyana Shekhtman, Michael Gershovits, Shlomit Gilad, Caterina Chillotti, Alessio Squassina, James B Potash, Thomas G Schulze, Fernando S Goes, Peter Zandi, John R Kelsoe, David Gurwitz
OBJECTIVES: Lithium remains the oldest and most effective treatment for mood stabilisation in bipolar disorder (BD), even though at least half of patients are only partially responsive or do not respond. This study aimed to identify biomarkers associated with lithium response in BD, based on comparing RNA sequencing information derived from lymphoblastoid cell lines (LCLs) of lithium-responsive (LR) versus lithium non-responsive (LNR) BD patients, to assess gene expression variations that might bear on treatment outcome...
September 22, 2017: World Journal of Biological Psychiatry
https://www.readbyqxmd.com/read/28845175/microstructural-abnormalities-of-basal-ganglia-and-thalamus-in-bipolar-and-unipolar-disorders-a-diffusion-kurtosis-and-perfusion-imaging-study
#15
Lianping Zhao, Ying Wang, Yanbin Jia, Shuming Zhong, Yao Sun, Zhifeng Zhou, Zhongping Zhang, Li Huang
OBJECTIVE: Bipolar disorder (BD) is often misdiagnosed as unipolar depression (UD), leading to mistreatment and poor clinical outcomes. However, little is known about the similarities and differences in subcorticalgray matter regions between BD and UD. METHODS: Thirty-five BD patients, 30 UD patients and 40 healthy controls underwent diffusional kurtosis imaging (DKI) and three dimensional arterial spin labeling (3D ASL). The parameters including mean kurtosis (MK), axial kurtosis (Ka), radial kurtosis (Kr), fractional anisotropy (FA), mean diffusivity (MD), axial diffusivity (Da), radial diffusivity (Dr) and cerebral blood flow (CBF) were measured by using regions-of-interest analysis in the caudate, putamen and thalamus of the subcortical gray matter regions...
July 2017: Psychiatry Investigation
https://www.readbyqxmd.com/read/28834020/relationships-between-corpus-callosum-and-language-lateralization-in-patients-with-schizophrenia-and-bipolar-disorders
#16
Maxime Tréhout, Elise Leroux, Nicolas Delcroix, Sonia Dollfus
OBJECTIVES: The question of whether there is a continuum or a dichotomy among patients with schizophrenia (SZ) and bipolar disorders (BD) has not been clearly resolved and remains a challenge. Thus, the identification of specific biomarkers of these disorders might be helpful. The present study investigated the volume of the corpus callosum (CC) and functional lateralization for language as potential biomarkers and their relationships in SZ and BD. METHODS: The study included 20 patients with SZ, 20 patients with BD and 40 healthy controls (HC)...
August 23, 2017: Bipolar Disorders
https://www.readbyqxmd.com/read/28833866/total-sleep-time-and-kynurenine-metabolism-associated-with-mood-symptom-severity-in-bipolar-disorder
#17
Dahlia Mukherjee, Venkatesh Bassapa Krishnamurthy, Caitlin E Millett, Aubrey Reider, Adem Can, Maureen Groer, Dietmar Fuchs, Teodor T Postolache, Erika F H Saunders
OBJECTIVE: Chronic, low-level inflammation is associated with symptomatic bipolar disorder (BD) and with chronic insomnia. Disrupted sleep is a feature of episodes of both mania and depression. We examined the effect of neopterin, a marker of cellular immune activation, and kynurenine (KYN), an inflammatory byproduct of the serotonin pathway, on the association between total sleep time and depression severity in BD. METHOD: Twenty-one symptomatic BD participants and 28 healthy controls (HC) were recruited and followed during usual clinical care...
August 23, 2017: Bipolar Disorders
https://www.readbyqxmd.com/read/28809398/precision-medicine-for-suicidality-from-universality-to-subtypes-and-personalization
#18
A B Niculescu, H Le-Niculescu, D F Levey, P L Phalen, H L Dainton, K Roseberry, E M Niculescu, J O Niezer, A Williams, D L Graham, T J Jones, V Venugopal, A Ballew, M Yard, T Gelbart, S M Kurian, A Shekhar, N J Schork, G E Sandusky, D R Salomon
Suicide remains a clear, present and increasing public health problem, despite being a potentially preventable tragedy. Its incidence is particularly high in people with overt or un(der)diagnosed psychiatric disorders. Objective and precise identification of individuals at risk, ways of monitoring response to treatments and novel preventive therapeutics need to be discovered, employed and widely deployed. We sought to investigate whether blood gene expression biomarkers for suicide (that is, a 'liquid biopsy' approach) can be identified that are more universal in nature, working across psychiatric diagnoses and genders, using larger cohorts than in previous studies...
September 2017: Molecular Psychiatry
https://www.readbyqxmd.com/read/28760539/dissociable-auditory-mismatch-response-and-connectivity-patterns-in-adolescents-with-schizophrenia-and-adolescents-with-bipolar-disorder-with-psychosis-a-magnetoencephalography-study
#19
Sven Braeutigam, Danai Dima, Sophia Frangou, Anthony James
BACKGROUND: There is overlap between schizophrenia and bipolar disorder regarding genetic risk as well as neuropsychological and structural brain deficits. Finding common and distinct event-response potential (ERP) responses and connectivity patterns may offer potential biomarkers to distinguish the disorders. OBJECTIVE: To examine the neuronal auditory response elicited by a roving mismatch negativity (MMN) paradigm using magnetoencephalography (MEG). PARTICIPANTS: 15 Adolescents with schizophrenia (ASZ), 16 adolescents with bipolar disorder with psychosis (ABP), and 14 typically developing individuals (TD) METHODS: The data were analysed using time-series techniques and dynamic causal modelling (DCM)...
July 28, 2017: Schizophrenia Research
https://www.readbyqxmd.com/read/28711724/neurotrophic-and-inflammatory-markers-in-bipolar-disorder-a-prospective-study
#20
Seline van den Ameele, Violette Coppens, Jeroen Schuermans, Peter De Boer, Maarten Timmers, Erik Fransen, Bernard Sabbe, Manuel Morrens
Altered neurotrophic signaling is thought to impair neuroplasticity in bipolar disorder (BD). Brain-derived neurotrophic factor (BDNF) is proposed as a neurotrophic marker in BD. However, the current evidence for its use in monitoring disease activity and illness progression is conflicting and an exploration of additional neurotrophic markers is needed. This prospective case-control study investigated mood-specific changes in potential neurotrophic markers and their association to inflammatory activity. Patients with BD were included during an acute mood episode, either depressive (n=35) or (hypo)manic (n=32)...
July 5, 2017: Psychoneuroendocrinology
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