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major depressive disorder biomarkers

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https://www.readbyqxmd.com/read/28441588/reduced-ena78-levels-as-novel-biomarker-for-major-depressive-disorder-and-venlafaxine-efficiency-result-from-a-prospective-longitudinal-study
#1
Zezhi Li, Zuowei Wang, Chen Zhang, Jun Chen, Yousong Su, Jia Huang, Zhenghui Yi, Chengmei Yuan, Wu Hong, Yong Wang, Zhiguo Wu, Yingyan Hu, Lan Cao, Daihui Peng, Yangtai Guan, Yimin Zou, Shunying Yu, Donghong Cui, Yiru Fang
Although lines of evidence demonstrated that cytokines play an important role in the pathogenesis of major depressive disorder (MDD), none of the them have been established as reliable biomarkers. We use our previous whole-genome cRNA microarray data to identify epithelial cell-derived neutrophil-activating peptide 78 (ENA78), the most differentially expressed cytokine in peripheral blood between MDD patients and healthy controls; and then we confirmed the result by the quantitative reverse transcription-polymerase chain reaction (RT-qPCR) and enzyme-linked immunosorbent assay (ELISA) for mRNA and protein level, respectively, in an independent drug-naïve first-episode sample set...
March 18, 2017: Psychoneuroendocrinology
https://www.readbyqxmd.com/read/28439746/plasma-phosphatidylethanolamine-and-triacylglycerol-fatty-acid-concentrations-are-altered-in-major-depressive-disorder-patients-with-seasonal-pattern
#2
Yurika Otoki, Marie Hennebelle, Anthony J Levitt, Kiyotaka Nakagawa, Walter Swardfager, Ameer Y Taha
Disturbances in peripheral and brain lipid metabolism, including the omega-3 fatty acid docosahexaenoic acid (DHA), have been reported in major depressive disorder (MDD). However, these changes have yet to be confirmed in MDD with seasonal pattern (MDD-s), a subtype of recurrent MDD. The present exploratory study quantified plasma plasmalogen and diacyl-phospholipid species, and fatty acids within total phospholipids, cholesteryl esters, triacylglycerols and free fatty acids in non-medicated MDD-s participants (n = 9) during euthymia in summer or fall, and during depression in winter in order to screen for potential high sensitivity lipid biomarkers...
April 24, 2017: Lipids
https://www.readbyqxmd.com/read/28438543/modulation-of-motor-cortex-excitability-predicts-antidepressant-response-to-prefrontal-cortex-repetitive-transcranial-magnetic-stimulation
#3
Albino J Oliveira-Maia, Daniel Press, Alvaro Pascual-Leone
BACKGROUND: Repetitive transcranial magnetic stimulation (rTMS) targeting the left dorsolateral prefrontal cortex (DLPFC) is a treatment option for patients with medication-resistant major depressive disorder (MDD). However, antidepressant response is variable and there are currently no response predictors with sufficient accuracy for clinical use. OBJECTIVE: We report on results of an observational open-label study to determine whether the modulatory effect of 10 Hz motor cortex (MC) rTMS is predictive of the antidepressant effect of 10 Hz DLPFC rTMS...
March 31, 2017: Brain Stimulation
https://www.readbyqxmd.com/read/28438472/shared-metabolic-and-immune-inflammatory-oxidative-and-nitrosative-stress-pathways-in-the-metabolic-syndrome-and-mood-disorders
#4
REVIEW
Luiz Gustavo Piccoli de Melo, Sandra Odebrecht Vargas Nunes, George Anderson, Heber Odebrecht Vargas, Décio Sabbattini Barbosa, Piotr Galecki, André F Carvalho, Michael Maes
This review examines the shared immune-inflammatory, oxidative and nitrosative stress (IO&NS) and metabolic pathways underpinning metabolic syndrome (MetS), bipolar disorder (BD) and major depressive disorder (MDD). Shared pathways in both MetS and mood disorders are low grade inflammation, including increased levels of pro-inflammatory cytokines and acute phase proteins, increased lipid peroxidation with formation of malondialdehyde and oxidized low density lipoprotein cholesterol (LDL-c), hypernitrosylation, lowered levels of antioxidants, most importantly zinc and paraoxonase (PON1), increased bacterial translocation (leaky gut), increased atherogenic index of plasma and Castelli risk indices; and reduced levels of high-density lipoprotein (HDL-c) cholesterol...
April 21, 2017: Progress in Neuro-psychopharmacology & Biological Psychiatry
https://www.readbyqxmd.com/read/28382573/serum-global-metabolomics-profiling-reveals-profound-metabolic-impairments-in-patients-with-mps-iiia-and-mps-iiib
#5
Haiyan Fu, Aaron S Meadows, Ricardo J Pineda, Robert P Mohney, Steve Stirdivant, Douglas M McCarty
The monogenic defects in specific lysosomal enzymes in mucopolysaccharidosis (MPS) III lead to lysosomal storage of glycosaminoglycans and complex CNS and somatic pathology, for which the detailed mechanisms remain unclear. In this study, serum samples from patients with MPS IIIA (age 2-9 yr) and MPS IIIB (2-13 yr) and healthy controls (age 2-9 yr) were assayed by global metabolomics profiling of 658 metabolites using mass spectrometry. Significant alterations were detected in 423 metabolites in all MPS III patients, of which 366 (86...
April 5, 2017: Metabolic Brain Disease
https://www.readbyqxmd.com/read/28375203/the-serum-protein-levels-of-the-tpa-bdnf-pathway-are-implicated-in-depression-and-antidepressant-treatment
#6
H Jiang, S Chen, C Li, N Lu, Y Yue, Y Yin, Y Zhang, X Zhi, D Zhang, Y Yuan
Evidence demonstrates that brain-derived neurotrophic factor (BDNF) has a pivotal role in the pathogenesis of major depressive disorder (MDD). Precursor-BDNF (proBDNF) and mature BDNF (mBDNF) have opposing biological effects in neuroplasticity, and the tissue-type plasminogen activator (tPA)/plasmin system is crucial in the cleavage processing of proBDNF to mBDNF. However, very little is known about the role of the tPA-BDNF pathway in MDD. We examined serum protein concentrations in the tPA-BDNF pathway, including tPA, BDNF, tropomyosin receptor kinase B (TrkB), proBDNF and p75NTR, obtained from 35 drug-free depressed patients before and after 8 weeks of escitalopram (mean 12...
April 4, 2017: Translational Psychiatry
https://www.readbyqxmd.com/read/28371072/can-lncrnas-be-indicators-for-the-diagnosis-of-early-onset-or-acute-schizophrenia-and-distinguish-major-depressive-disorder-and-generalized-anxiety-disorder-a-cross-validation-analysis
#7
Xuelian Cui, Wei Niu, Lingming Kong, Mingjun He, Kunhong Jiang, Shengdong Chen, Aifang Zhong, Wanshuai Li, Jim Lu, Liyi Zhang
Depression and anxiety are apparent symptoms in the early onset or acute phase of schizophrenia (SZ), which complicate timely diagnosis and treatment. It is imperative to seek an indicator to distinguish schizophrenia from depressive and anxiety disorders. Using lncRNA microarray profiling and RT-PCR, three up-regulated lncRNAs in SZ, six down-regulated lncRNAs in major depressive disorder (MDD), and three up-regulated lncRNAs in generalized anxiety disorder (GAD) had been identified as potential biomarkers...
March 28, 2017: American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics
https://www.readbyqxmd.com/read/28367128/the-role-of-norepinephrine-and-its-%C3%AE-adrenergic-receptors-in-the-pathophysiology-and-treatment-of-major-depressive-disorder-and-schizophrenia-a-systematic-review
#8
REVIEW
Vladimir Maletic, Anna Eramo, Keva Gwin, Steve J Offord, Ruth A Duffy
Norepinephrine (NE) is recognized as having a key role in the pathophysiology of major depressive disorder (MDD) and schizophrenia, although its distinct actions via α-adrenergic receptors (α-ARs) are not well defined. We performed a systematic review examining the roles of NE and α-ARs in MDD and schizophrenia. PubMed and ProQuest database searches were performed to identify English language papers published between 2008 and 2015. In total, 2,427 publications (PubMed, n = 669; ProQuest, n = 1,758) were identified...
2017: Frontiers in Psychiatry
https://www.readbyqxmd.com/read/28362541/can-neurophysiologic-measures-serve-as-biomarkers-for-the-efficacy-of-repetitive-transcranial-magnetic-stimulation-treatment-of-major-depressive-disorder
#9
Brian Kobayashi, Ian A Cook, Aimee M Hunter, Michael J Minzenberg, David E Krantz, Andrew F Leuchter
Repetitive transcranial magnetic stimulation (rTMS) is an effective treatment for Major Depressive Disorder (MDD). There are clinical data that support the efficacy of many different approaches to rTMS treatment, and it remains unclear what combination of stimulation parameters is optimal to relieve depressive symptoms. Because of the costs and complexity of studies that would be necessary to explore and compare the large number of combinations of rTMS treatment parameters, it would be useful to establish reliable surrogate biomarkers of treatment efficacy that could be used to compare different approaches to treatment...
March 31, 2017: International Review of Psychiatry
https://www.readbyqxmd.com/read/28353227/connecting-brain-proteomics-with-behavioural-neuroscience-in-translational-animal-models-of-neuropsychiatric-disorders
#10
Zoltán Sarnyai, Paul C Guest
Modelling psychiatric disorders in animals has been hindered by several challenges related to our poor understanding of the disease causes. This chapter describes recent advances in translational research which may lead to animal models and relevant proteomic biomarkers that can be informative about disease mechanisms and potential new therapeutic targets. The review focuses on the behavioural and molecular correlates in models of schizophrenia and major depressive disorder, as guided by recently established Research Domain Criteria (RDoC)...
2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/28345197/attenuated-intrinsic-connectivity-within-cognitive-control-network-among-individuals-with-remitted-depression-temporal-stability-and-association-with-negative-cognitive-styles
#11
Jonathan P Stange, Katie L Bessette, Lisanne M Jenkins, Amy T Peters, Claudia Feldhaus, Natania A Crane, Olusola Ajilore, Rachel H Jacobs, Edward R Watkins, Scott A Langenecker
Many individuals with major depressive disorder (MDD) experience cognitive dysfunction including impaired cognitive control and negative cognitive styles. Functional connectivity magnetic resonance imaging studies of individuals with current MDD have documented altered resting-state connectivity within the default-mode network and across networks. However, no studies to date have evaluated the extent to which impaired connectivity within the cognitive control network (CCN) may be present in remitted MDD (rMDD), nor have studies examined the temporal stability of such attenuation over time...
March 27, 2017: Human Brain Mapping
https://www.readbyqxmd.com/read/28344075/functional-reorganization-in-obstructive-sleep-apnoea-and-insomnia-a-systematic-review-of-the-resting-state-fmri
#12
REVIEW
Habibolah Khazaie, Mattia Veronese, Khadijeh Noori, Farnoosh Emamian, Mojtaba Zarei, Keyoumars Ashkan, Guy D Leschziner, Claudia R Eickhoff, Simon B Eickhoff, Mary J Morrell, Ricardo S Osorio, Kai Spiegelhalder, Masoud Tahmasian, Ivana Rosenzweig
Functional neuroimaging techniques have accelerated progress in the study of sleep disorders. Considering the striking prevalence of these disorders in the general population, however, as well as their strong bidirectional relationship with major neuropsychiatric disorders, including major depressive disorder, their numbers are still surprisingly low. This review examines the contribution of resting state functional MRI to current understanding of two major sleep disorders, insomnia disorder and obstructive sleep apnoea...
March 23, 2017: Neuroscience and Biobehavioral Reviews
https://www.readbyqxmd.com/read/28335622/functional-connectivity-of-the-subcallosal-cingulate-cortex-and-differential-outcomes-to-treatment-with-cognitive-behavioral-therapy-or-antidepressant-medication-for-major-depressive-disorder
#13
Boadie W Dunlop, Justin K Rajendra, W Edward Craighead, Mary E Kelley, Callie L McGrath, Ki Sueng Choi, Becky Kinkead, Charles B Nemeroff, Helen S Mayberg
OBJECTIVE: The purpose of this article was to inform the first-line treatment choice between cognitive-behavioral therapy (CBT) or an antidepressant medication for treatment-naive adults with major depressive disorder by defining a neuroimaging biomarker that differentially identifies the outcomes of remission and treatment failure to these interventions. METHOD: Functional MRI resting-state functional connectivity analyses using a bilateral subcallosal cingulate cortex (SCC) seed was applied to 122 patients from the Prediction of Remission to Individual and Combined Treatments (PReDICT) study who completed 12 weeks of randomized treatment with CBT or antidepressant medication...
March 24, 2017: American Journal of Psychiatry
https://www.readbyqxmd.com/read/28324704/bxd-recombinant-inbred-strains-participate-in-social-preference-anxiety-and-depression-behaviors-along-sex-differences-in-cytokines-and-tactile-allodynia
#14
Caridad López-Granero, Alessandra Antunes Dos Santos, Beatriz Ferrer, Megan Culbreth, Sudipta Chakraborty, Angel Barrasa, Maria Gulinello, Aaron B Bowman, Michael Aschner
Depression and anxiety are the most common psychiatric disorders, representing a major public health concern. Dysregulation of oxidative and inflammatory systems may be associated with psychiatric disorders, such as depression and anxiety. Due to the need to find appropriate animal models to the understanding of such disorders, we queried whether 2 BXD recombinant inbred (RI) mice strains (BXD21/TyJ RI and BXD84/RwwJ RI mice) and C57BL/6 wild-type mice show differential performance in depression and anxiety related behaviors and biomarkers...
March 6, 2017: Psychoneuroendocrinology
https://www.readbyqxmd.com/read/28293473/separating-generalized-anxiety-disorder-from-major-depression-using-clinical-hormonal-and-structural-mri-data-a-multimodal-machine-learning-study
#15
Kevin Hilbert, Ulrike Lueken, Markus Muehlhan, Katja Beesdo-Baum
BACKGROUND: Generalized anxiety disorder (GAD) is difficult to recognize and hard to separate from major depression (MD) in clinical settings. Biomarkers might support diagnostic decisions. This study used machine learning on multimodal biobehavioral data from a sample of GAD, MD and healthy subjects to differentiate subjects with a disorder from healthy subjects (case-classification) and to differentiate GAD from MD (disorder-classification). METHODS: Subjects with GAD (n = 19), MD without GAD (n = 14), and healthy comparison subjects (n = 24) were included...
March 2017: Brain and Behavior
https://www.readbyqxmd.com/read/28290081/potential-use-of-microrna-for-monitoring-therapeutic-response-to-antidepressants
#16
Raoul Belzeaux, Rixing Lin, Gustavo Turecki
Major depressive disorder (MDD) is a serious and common psychiatric disorder that affects millions of people worldwide. The most common treatment methods for MDD are antidepressant drugs, many of which act by regulating monoamines by inhibiting pre-synaptic reuptake and/or by modulating monoamine receptors. Despite advances in antidepressants and other treatment options, therapy is often based on subjective decisions made by the physician. Moreover, it requires time to determine treatment outcome and to define whether the prescribed treatment is effective...
March 13, 2017: CNS Drugs
https://www.readbyqxmd.com/read/28262603/biological-profiling-of-prospective-antidepressant-response-in-major-depressive-disorder-associations-with-neuro-inflammation-fatty-acid-metabolism-and-amygdala-reactivity
#17
R J T Mocking, T S Nap, A M Westerink, J Assies, F M Vaz, M W J Koeter, H G Ruhé, A H Schene
BACKGROUND: A better understanding of factors underlying antidepressant non-response may improve the prediction of which patients will respond to what treatment. Major depressive disorder (MDD) is associated with alterations in fatty acid metabolism, (neuro)inflammation and amygdala-reactivity. However, their mutual relations, and the extent to which they are associated with prospective antidepressant-response, remain unknown. PURPOSE: To test (I) alterations in (neuro)inflammation and its associations with fatty acid metabolism and amygdala-reactivity in MDD-patients compared to controls, and (II) whether these alterations are associated with prospective paroxetine response...
February 21, 2017: Psychoneuroendocrinology
https://www.readbyqxmd.com/read/28237506/eeg-connectivity-between-the-subgenual-anterior-cingulate-and-prefrontal-cortices-in-response-to-antidepressant-medication
#18
Tabitha A Iseger, Mayuresh S Korgaonkar, J Leon Kenemans, Stuart M Grieve, Chris Baeken, Paul B Fitzgerald, Martijn Arns
Antidepressant medication is the most common treatment for major depressive disorder (MDD), however, the precise working mechanism underlying these treatments remains unclear. Recent neuromodulation treatments demonstrate that direct stimulation of the dorsolateral prefrontal cortex (DLPFC), dorsomedial prefrontal cortex (DMPFC), and subgenual anterior cingulate (sgACC) relate to clinical improvement, suggesting connectivity alterations of the DLPFC-DMPFC-sgACC network to mediate antidepressant response. The international Study to Predict Optimized Treatment in Depression (iSPOT-D) is an international multicentre study that collected EEG data for 1008 MDD patients, randomized to 3 different antidepressant medications (N=447 MDD with complete pre- and post-treatment data and N=336 non-MDD)...
February 22, 2017: European Neuropsychopharmacology: the Journal of the European College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/28223106/diagnosis-of-major-depressive-disorder-by-combining-multimodal-information-from-heart-rate-dynamics-and-serum-proteomics-using-machine-learning-algorithm
#19
Eun Young Kim, Min Young Lee, Se Hyun Kim, Kyooseob Ha, Kwang Pyo Kim, Yong Min Ahn
OBJECTIVE: Major depressive disorder (MDD) is a systemic and multifactorial disorder that involves abnormalities in multiple biochemical pathways and the autonomic nervous system. This study applied a machine-learning method to classify MDD and control groups by incorporating data from serum proteomic analysis and heart rate variability (HRV) analysis for the identification of novel peripheral biomarkers. METHODS: The study subjects consisted of 25 drug-free female MDD patients and 25 age- and sex-matched healthy controls...
February 20, 2017: Progress in Neuro-psychopharmacology & Biological Psychiatry
https://www.readbyqxmd.com/read/28205606/differential-abnormal-pattern-of-anterior-cingulate-gyrus-activation-in-unipolar-and-bipolar-depression-an-fmri-and-pattern-classification-approach
#20
Christian Bürger, Ronny Redlich, Dominik Grotegerd, Susanne Meinert, Katharina Dohm, Ilona Schneider, Dario Zaremba, Katharina Förster, Judith Alferink, Jens Bölte, Walter Heindel, Harald Kugel, Volker Arolt, Udo Dannlowski
Distinguishing bipolar disorder from major depressive disorder is a major challenge in psychiatric treatment. Consequently, there has been growing interest in identifying neuronal biomarkers of disorder-specific pathophysiological processes to differentiate affective disorders. Thirty-six depressed bipolar patients, 36 depressed unipolar patients and 36 matched healthy controls participated in an fMRI-experiment. Emotional faces served as stimuli in a matching task. We investigated neural activation towards angry, fearful and happy faces focusing on prototypical regions related to emotion processing, ie the amygdala and the anterior cingulate gyrus (ACG)...
February 16, 2017: Neuropsychopharmacology: Official Publication of the American College of Neuropsychopharmacology
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