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major depressive disorder biomarkers

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https://www.readbyqxmd.com/read/29895893/what-does-plasma-crp-tell-us-about-peripheral-and-central-inflammation-in-depression
#1
Jennifer C Felger, Ebrahim Haroon, Trusharth A Patel, David R Goldsmith, Evanthia C Wommack, Bobbi J Woolwine, Ngoc-Anh Le, Rachel Feinberg, Malu G Tansey, Andrew H Miller
Peripheral blood C-reactive protein (CRP) is a biomarker used clinically to measure systemic inflammation and is reproducibly increased in a subset of patients with major depressive disorder (MDD). Furthermore, increased peripheral blood CRP in MDD has been associated with altered reward circuitry and increased brain glutamate in relation with symptoms of anhedonia. Nevertheless, the relationship between peripheral CRP and other peripheral and central markers of inflammation in depressed patients has not been established...
June 12, 2018: Molecular Psychiatry
https://www.readbyqxmd.com/read/29895759/classical-risk-factors-and-inflammatory-biomarkers-one-of-the-missing-biological-links-between-cardiovascular-disease-and-major-depressive-disorder
#2
Thomas C Baghai, Gabriella Varallo-Bedarida, Christoph Born, Sibylle Häfner, Cornelius Schüle, Daniela Eser, Peter Zill, André Manook, Johannes Weigl, Somayeh Jooyandeh, Caroline Nothdurfter, Clemens von Schacky, Brigitta Bondy, Rainer Rupprecht
BACKGROUND: Cardiovascular disorders (CVD) and major depressive disorder (MDD) are the most frequent diseases worldwide responsible for premature death and disability. Behavioral and immunological variables influence the pathophysiology of both disorders. We therefore determined frequency and severity of MDD in CVD and studied whether MDD without CVD or other somatic diseases influences classical and inflammatory biomarkers of cardiovascular risk. In addition, we investigated the influence of proinflammatory cytokines on antidepressant treatment outcome...
June 12, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29894705/plasma-biomarkers-in-a-placebo-controlled-trial-comparing-tdcs-and-escitalopram-efficacy-in-major-depression
#3
André R Brunoni, Frank Padberg, Erica Leandro Marciano Vieira, Antônio Lucio Teixeira, André F Carvalho, Paulo Andrade Lotufo, Wagner F Gattaz, Isabela Martins Benseñor
BACKGROUND: Transcranial direct current stimulation (tDCS) holds promise as a therapeutic intervention for major depressive disorder (MDD). A more precise understanding of its underlying mechanisms may aid in the identification of subsets of patients responsive to tDCS within the context of precision psychiatry. OBJECTIVE: In this ancillary investigation of the Escitalopram vs. Electrical Current Therapy for Treating Depression Clinical Study (ELECT-TDCS), we investigated whether plasma levels of several cytokines and neurotrophic factors associated with major depression or antidepressant response predicted tDCS effects...
June 9, 2018: Progress in Neuro-psychopharmacology & Biological Psychiatry
https://www.readbyqxmd.com/read/29886088/a-pilot-study-of-gaba-b-correlates-with-resting-state-functional-connectivity-in-five-depressed-female-adolescents
#4
Irena Balzekas, Charles P Lewis, Julia Shekunov, John D Port, Gregory A Worrell, Hang Joon Jo, Paul E Croarkin
Connectivity features based on resting-state (RS) functional magnetic resonance imaging (fMRI) demonstrate great promise as biomarkers to guide diagnosis and treatment in major depressive disorder (MDD). However, there is a pressing need for valid, reliable biomarkers closer to the bedside for clinical research and practice. This study directly compared RS-fMRI connectivity features with transcranial magnetic stimulation (TMS) neurophysiological measures, long interval cortical inhibition (LICI) and cortical silent period (CSP), in female adolescents with MDD...
May 31, 2018: Psychiatry research. Neuroimaging
https://www.readbyqxmd.com/read/29879133/predictive-modeling-of-treatment-resistant-depression-using-data-from-star-d-and-an-independent-clinical-study
#5
Zhi Nie, Srinivasan Vairavan, Vaibhav A Narayan, Jieping Ye, Qingqin S Li
Identification of risk factors of treatment resistance may be useful to guide treatment selection, avoid inefficient trial-and-error, and improve major depressive disorder (MDD) care. We extended the work in predictive modeling of treatment resistant depression (TRD) via partition of the data from the Sequenced Treatment Alternatives to Relieve Depression (STAR*D) cohort into a training and a testing dataset. We also included data from a small yet completely independent cohort RIS-INT-93 as an external test dataset...
2018: PloS One
https://www.readbyqxmd.com/read/29867602/cognitive-and-neurophysiological-recovery-following-electroconvulsive-therapy-a-study-protocol
#6
Ben J A Palanca, Hannah R Maybrier, Angela M Mickle, Nuri B Farber, R Edward Hogan, Emma R Trammel, J Wylie Spencer, Donald D Bohnenkamp, Troy S Wildes, ShiNung Ching, Eric Lenze, Mathias Basner, Max B Kelz, Michael S Avidan
Electroconvulsive therapy (ECT) employs the elective induction of generalizes seizures as a potent treatment for severe psychiatric illness. As such, ECT provides an opportunity to rigorously study the recovery of consciousness, reconstitution of cognition, and electroencephalographic (EEG) activity following seizures. Fifteen patients with major depressive disorder refractory to pharmacologic therapy will be enrolled (Clinicaltrials.gov, NCT02761330). Adequate seizure duration will be confirmed following right unilateral ECT under etomidate anesthesia...
2018: Frontiers in Psychiatry
https://www.readbyqxmd.com/read/29860184/attempted-suicide-and-oxytocin-related-gene-polymorphisms
#7
Michelle S Parris, Michael F Grunebaum, Hanga C Galfalvy, Ana Andronikashvili, Ainsley K Burke, Honglei Yin, Eli Min, Yung-Yu Huang, J John Mann
BACKGROUND: Oxytocin may moderate prosocial behaviors, but has also been implicated in negative mental health outcomes. A single-nucleotide polymorphism (SNP) of the oxytocin receptor gene (OXTR), rs53576, and a SNP of the CD38 gene, which regulates oxytocin secretion, rs3796863, have been associated with depression and suicidal ideation. METHODS: We conducted an exploratory study investigating the relationship of these two SNPs to history of suicide attempt. Secondary analyses explored relationships of genotype with sex, diagnosis, history of abuse, depression, suicidal ideation, and attachment and personality traits...
May 17, 2018: Journal of Affective Disorders
https://www.readbyqxmd.com/read/29803529/resilience-and-white-matter-integrity-in-geriatric-depression
#8
Roza M Vlasova, Prabha Siddarth, Beatrix Krause, Amber M Leaver, Kelsey T Laird, Natalie St Cyr, Katherine L Narr, Helen Lavretsky
OBJECTIVE: Greater psychological resilience may protect against developing depression in a growing geriatric population. Identifying the neural correlates of resilience in geriatric depression could provide neurobiologic targets to inform clinical interventions. However, most prior neuroimaging studies have only considered the presence or absence of resilience and have not addressed the multifactorial nature of resilience. The current study aimed to establish the neural correlates of four factors of resilience in the depressed elderly...
April 23, 2018: American Journal of Geriatric Psychiatry
https://www.readbyqxmd.com/read/29794033/prediction-of-response-to-drug-therapy-in-psychiatric-disorders
#9
REVIEW
Shani Stern, Sara Linker, Krishna C Vadodaria, Maria C Marchetto, Fred H Gage
Personalized medicine has become increasingly relevant to many medical fields, promising more efficient drug therapies and earlier intervention. The development of personalized medicine is coupled with the identification of biomarkers and classification algorithms that help predict the responses of different patients to different drugs. In the last 10 years, the Food and Drug Administration (FDA) has approved several genetically pre-screened drugs labelled as pharmacogenomics in the fields of oncology, pulmonary medicine, gastroenterology, haematology, neurology, rheumatology and even psychiatry...
May 2018: Open Biology
https://www.readbyqxmd.com/read/29783087/association-of-t-and-non-t-cell-cytokines-with-anhedonia-role-of-gender-differences
#10
Manish K Jha, Andrew H Miller, Abu Minhajuddin, Madhukar H Trivedi
OBJECTIVE: Among individual depressive symptoms, anhedonia has been reliably associated with activation of the innate immune response. However, it is unclear whether this association extends to T cell cytokines and if gender differentially affects this association. METHOD: Concentrations of T (IL-17, T-helper (Th) 1- and Th2-) and non-T cell cytokines were measured in plasma using the Bioplex Pro™ human cytokine multiplex kit in Combining Medications to Enhance Depression Outcomes (CO-MED) trial participants who provided plasma at baseline (n = 166)...
May 12, 2018: Psychoneuroendocrinology
https://www.readbyqxmd.com/read/29781643/microstructural-integrity-of-a-pathway-connecting-the-prefrontal-cortex-and-amygdala-moderates-the-association-between-cognitive-reappraisal-and-negative-emotions
#11
Tracy C d'Arbeloff, M Justin Kim, Annchen R Knodt, Spenser R Radtke, Bartholomew D Brigidi, Ahmad R Hariri
Cognitive reappraisal is a commonly used form of emotion regulation that utilizes frontal-executive control to reframe an approaching emotional event to moderate its potential psychological impact. Use of cognitive reappraisal has been associated with diminished experience of anxiety and depressive symptoms, as well as greater overall well-being. Using data from a study of 647 healthy young adults, we provide initial evidence that an association between typical use of cognitive reappraisal in daily life and the experience of anxiety and depressive symptoms is moderated by the microstructural integrity of the uncinate fasciculus, which provides a major anatomical link between the amygdala and prefrontal cortex...
May 21, 2018: Emotion
https://www.readbyqxmd.com/read/29770218/elevated-serum-levels-of-malondialdehyde-and-cortisol-are-associated-with-major-depressive-disorder-a-case-control-study
#12
Md Rabiul Islam, Md Reazul Islam, Imtiaz Ahmed, Abdullah Al Moktadir, Zabun Nahar, Mohammad Safiqul Islam, Shelina Fatema Binte Shahid, Sheikh Nazrul Islam, Md Saiful Islam, Abul Hasnat
Objectives: Major depressive disorder is diagnosed on the basis of patient's self-reported experiences, behavior reported by relatives, and a mental status examination, and yet we do not have any reliable biomarker for this. Mood-regulating pathways are affected by oxidative injury to lipids and cortisol is released into the blood due to stimulation of corticotrophin receptors in the adrenal cortex. Here, we aimed to determine serum levels of malondialdehyde and cortisol in major depressive disorder patients and controls...
2018: SAGE Open Medicine
https://www.readbyqxmd.com/read/29764522/treatment-resistant-depression-and-peripheral-c-reactive-protein
#13
Samuel R Chamberlain, Jonathan Cavanagh, Peter de Boer, Valeria Mondelli, Declan N C Jones, Wayne C Drevets, Philip J Cowen, Neil A Harrison, Linda Pointon, Carmine M Pariante, Edward T Bullmore
BACKGROUND: C-reactive protein (CRP) is a candidate biomarker for major depressive disorder (MDD), but it is unclear how peripheral CRP levels relate to the heterogeneous clinical phenotypes of the disorder.AimTo explore CRP in MDD and its phenotypic associations. METHOD: We recruited 102 treatment-resistant patients with MDD currently experiencing depression, 48 treatment-responsive patients with MDD not currently experiencing depression, 48 patients with depression who were not receiving medication and 54 healthy volunteers...
May 16, 2018: British Journal of Psychiatry: the Journal of Mental Science
https://www.readbyqxmd.com/read/29764272/does-s100b-have-a-potential-role-in-affective-disorders-a-literature-review
#14
Hilda Kroksmark, Maj Vinberg
BACKGROUND: S100B is a calcium-binding protein located in glial cells; it is regarded as a potential biomarker in affective disorders. AIM: To review the literature investigating the role of S100B in patients with affective disorders. METHOD: A systematic review of original English language studies investigating S100B in serum, cerebrospinal fluid, plasma and lymphocytes, in patients with affective disorders, was conducted. The literature search was conducted within the PubMed database...
May 15, 2018: Nordic Journal of Psychiatry
https://www.readbyqxmd.com/read/29759000/biological-sex-differences-in-depression-a-systematic-review
#15
Ainitze Labaka, Olatz Goñi-Balentziaga, Andrea Lebeña, Joana Pérez-Tejada
Depression is the leading cause of disability worldwide, and its prevalence is 2 times higher in women than in men. There is, however, a lack of data on sex-specific pathophysiology of this disorder. The purpose of this systematic review is to identify the biological sex differences found in major depressive disorder (MDD) in studies published in the last 10 years. We conducted a literature search using the Medline, PsycInfo, PubMed, and Web of Science databases, selecting English-language studies that included physiological measures compared by sex in addition to MDD...
January 1, 2018: Biological Research for Nursing
https://www.readbyqxmd.com/read/29734005/complexity-analysis-of-spontaneous-brain-activity-in-mood-disorders-a-magnetoencephalography-study-of-bipolar-disorder-and-major-depression
#16
Alberto Fernández, Ali H Al-Timemy, Francisco Ferre, Gabriel Rubio, Javier Escudero
BACKGROUND AND PURPOSE: The lack of a biomarker for Bipolar Disorder (BD) causes problems in the differential diagnosis with other mood disorders such as major depression (MD), and misdiagnosis frequently occurs. Bearing this in mind, we investigated non-linear magnetoencephalography (MEG) patterns in BD and MD. METHODS: Lempel-Ziv Complexity (LZC) was used to evaluate the resting-state MEG activity in a cross-sectional sample of 60 subjects, including 20 patients with MD, 16 patients with BD type-I, and 24 control (CON) subjects...
April 26, 2018: Comprehensive Psychiatry
https://www.readbyqxmd.com/read/29719272/serum-lipidomic-analysis-for-the-discovery-of-biomarkers-for-major-depressive-disorder-in-drug-free-patients
#17
Eun Young Kim, Jae Won Lee, Min Young Lee, Se Hyun Kim, Hyuck Jun Mok, Kyooseob Ha, Yong Min Ahn, Kwang Pyo Kim
Lipidomic analysis can be used to efficiently identify hundreds of lipid molecular species in biological materials and has been recently established as an important tool for biomarker discovery in various neuropsychiatric disorders including major depressive disorder (MDD). In this study, quantitative targeted serum lipidomic profiling was performed on female subjects using liquid chromatography-mass spectrometry. Global lipid profiling of pooled serum samples from 10 patients currently with MDD (cMDD), 10 patients with remitted MDD (rMDD), and 10 healthy controls revealed 37 differentially regulated lipids (DRLs)...
April 25, 2018: Psychiatry Research
https://www.readbyqxmd.com/read/29701669/differentiating-medicated-patients-suffering-from-major-depressive-disorder-from-healthy-controls-by-spot-urine-measurement-of-monoamines-and-steroid-hormones
#18
Chandra S Wijaya, Jovia J Z Lee, Syeda F Husain, Cyrus S H Ho, Roger S McIntyre, Wilson W Tam, Roger C M Ho
Introduction : Major Depressive Disorder (MDD) is a common psychiatric disorder. Currently, there is no objective, cost-effective and non-invasive method to measure biological markers related to the pathogenesis of MDD. Previous studies primarily focused on urinary metabolite markers which are not proximal to the pathogenesis of MDD. Herein, we compare urinary monoamines, steroid hormones and the derived ratios amongst MDD when compared to healthy controls. Methods : Morning urine samples of medicated patients suffering from MDD ( n = 47) and healthy controls ( n = 41) were collected...
April 26, 2018: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/29696602/translational-shifts-in-preclinical-models-of-depression-implications-for-biomarkers-for-improved-treatments
#19
Chloe Slaney, Justyna K Hinchcliffe, Emma S J Robinson
Understanding the neurobiology of major depressive disorder (MDD) remains one of the major challenges in neuroscience. The disease is heterogeneous in nature, and patients present with a varied symptom profile. Studies seeking to identify biomarkers for MDD diagnosis and treatment have not yet found any one candidate which achieves sufficient sensitivity and specificity. In this article, we consider whether neuropsychological impairments, specifically affective biases, could provide a behavioural biomarker...
April 26, 2018: Current Topics in Behavioral Neurosciences
https://www.readbyqxmd.com/read/29696220/evaluating-the-efficacy-of-an-integrated-motivational-interviewing-and-multi-modal-exercise-intervention-for-youth-with-major-depression-healthy-body-healthy-mind-randomised-controlled-trial-protocol
#20
Yasmina Nasstasia, Amanda L Baker, Sean A Halpin, Leanne Hides, Terry J Lewin, Brian J Kelly, Robin Callister
Background: Recent meta-analytic reviews suggest exercise can reduce depression severity among adults with major depressive disorder (MDD); however, efficacy studies with depressed youth are limited. Few studies have investigated the efficacy of multi-modal exercise interventions in this population, addressed treatment engagement, or explored the differential effects of exercise on depressive symptom profiles. Objectives: This paper describes the study protocol and recruitment pattern for an assessor blinded, two-arm randomised controlled trial investigating the efficacy of an integrated motivational interviewing (MI) and multi-modal exercise intervention in youth diagnosed with MDD...
March 2018: Contemporary Clinical Trials Communications
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