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major depressive disorder biomarkers

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https://www.readbyqxmd.com/read/29681025/major-differences-in-neurooxidative-and-neuronitrosative-stress-pathways-between-major-depressive-disorder-and-types-i-and-ii-bipolar-disorder
#1
Michael Maes, Kamila Landucci Bonifacio, Nayara Rampazzo Morelli, Heber Odebrecht Vargas, Décio Sabbatini Barbosa, André F Carvalho, Sandra Odebrecht Vargas Nunes
Accumulating evidence indicates that oxidative and nitrosative stress (O&NS) pathways play a key role in the pathophysiology of bipolar disorder (BD) and major depressive disorder (MDD). However, only a handful of studies have directly compared alterations in O&NS pathways among patients with MDD and BD types I (BPI) and BPII. Thus, the current study compared superoxide dismutase (SOD1), lipid hydroperoxides (LOOH), catalase, nitric oxide metabolites (NOx), malondialdehyde (MDA), and advanced oxidation protein products (AOPP) between mood disorder patients in a clinically remitted state...
April 21, 2018: Molecular Neurobiology
https://www.readbyqxmd.com/read/29679072/polyunsaturated-fatty-acids-metabolism-purine-metabolism-and-inosine-as-potential-independent-diagnostic-biomarkers-for-major-depressive-disorder-in-children-and-adolescents
#2
Xinyu Zhou, Lanxiang Liu, Xinghui Lan, David Cohen, Yuqing Zhang, Arun V Ravindran, Shuai Yuan, Peng Zheng, David Coghill, Lining Yang, Sarah E Hetrick, Xiaofeng Jiang, Jean-Jacques Benoliel, Andrea Cipriani, Peng Xie
Major depressive disorder (MDD) in children and adolescents is a recurrent and disabling condition globally but its pathophysiology remains poorly elucidated and there are limited effective treatments available. We performed metabolic profiling of plasma samples based on ultra-high-performance liquid chromatography equipped with quadrupole time-offlight mass spectrometry to explore the potential biomarkers of depression in children and adolescents with MDD. We identified several perturbed pathways, including fatty acid metabolism-particularly the polyunsaturated fatty acids metabolism, and purine metabolism-that were associated with MDD in these young patients...
April 20, 2018: Molecular Psychiatry
https://www.readbyqxmd.com/read/29665163/lowered-quality-of-life-in-mood-disorders-is-associated-with-increased-neuro-oxidative-stress-and-basal-thyroid-stimulating-hormone-levels-and-use-of-anticonvulsant-mood-stabilizers
#3
Caroline Sampaio Nunes, Michael Maes, Chutima Roomruangwong, Juliana Brum Moraes, Kamila Landucci Bonifacio, Heber Odebrecht Vargas, Decio Sabbatini Barbosa, George Anderson, Luiz Gustavo Piccoli de Melo, Stoyanov Drozdstoj, Estefania Moreira, André F Carvalho, Sandra Odebrecht Vargas Nunes
RATIONALE, AIMS: Major affective disorders including bipolar disorder (BD) and major depressive disorder (MDD) are associated with impaired health-related quality of life (HRQoL). Oxidative stress and subtle thyroid abnormalities may play a pathophysiological role in both disorders. Thus, the current study was performed to examine whether neuro-oxidative biomarkers and thyroid-stimulating hormone (TSH) levels could predict HRQoL in BD and MDD. METHODS: This cross-sectional study enrolled 68 BD and 37 MDD patients and 66 healthy controls...
April 17, 2018: Journal of Evaluation in Clinical Practice
https://www.readbyqxmd.com/read/29660639/elevated-tumor-necrosis-factor-alpha-receptor-subtype-1-and-the-association-with-abnormal-brain-function-in-treatment-resistant-depression
#4
Mao-Hsuan Huang, Mu-Hong Chen, Pei-Chi Tu, Ya Mei Bai, Tung-Ping Su, Bang-Hung Yang, Ren-Shyan Liu, Cheng-Ta Li
BACKGROUND: Major depressive disorder (MDD) patients have shown elevated plasma levels of pro-inflammatory biomarkers compared to healthy controls. We hypothesized increased serum tumor necrosis factor-alpha receptor subtype 1 (TNF-α R1) is more associated with impaired brain function in patients with treatment-resistant depression (TRD) than those without TRD. METHODS: 34 MDD patients and 34 healthy subjects were recruited and we separated MDD patients to TRD group (n = 20) and non-TRD (n = 14) group...
April 6, 2018: Journal of Affective Disorders
https://www.readbyqxmd.com/read/29626340/neuroimmune-biomarkers-in-mental-illness
#5
James W Herron, Louis Nerurkar, Jonathan Cavanagh
Exploration of neuroimmune mechanisms is vital to the understanding of the pathogenesis and pathophysiology of mental disorders. Inflammatory and immune mechanisms are increasingly understood to underpin a number of neuropsychiatric disorders, with an ever-expanding evidence base drawn from basic science to large-scale epidemiological data. Unravelling of these mechanisms should lead to biomarker discovery and potential new avenues for therapeutics that modulate immunological mechanisms. Identification of neuroimmune biomarkers is vital to improving diagnosis, stratification and treatment of mental disorders...
April 7, 2018: Current Topics in Behavioral Neurosciences
https://www.readbyqxmd.com/read/29626337/network-neuroscience-a-framework-for-developing-biomarkers-in-psychiatry
#6
David M Lydon-Staley, Danielle S Bassett
Psychiatric disorders are disturbances of cognitive and behavioral processes mediated by the brain. Emerging evidence suggests that accurate biomarkers for psychiatric disorders might benefit from incorporating information regarding multiple brain regions and their interactions with one another, rather than considering local perturbations in brain structure and function alone. Recent advances in the field of applied mathematics generally - and network science specifically - provide a language to capture the complexity of interacting brain regions, and the application of this language to fundamental questions in neuroscience forms the emerging field of network neuroscience...
April 7, 2018: Current Topics in Behavioral Neurosciences
https://www.readbyqxmd.com/read/29614851/the-make-biomarker-discovery-for-enhancing-antidepressant-treatment-effect-and-response-study-design-and-methodology
#7
Hee-Ju Kang, Ju-Wan Kim, Seon-Young Kim, Sung-Wan Kim, Hee-Young Shin, Myung-Geun Shin, Jae-Min Kim
Objective: Depression is associated with a major disease burden, and many individuals suffer from depressive symptoms due to an insufficient response to ostensibly adequate antidepressant treatment. Therefore, it is important to identify reliable treatment response predictors for use in developing personalized treatment strategies. Methods: The MAKE Biomarker discovery for Enhancing anTidepressant Treatment Effect and Response (MAKE BETTER) study was performed to identify predictors of antidepressant response using a 2-year naturalistic prospective design...
April 5, 2018: Psychiatry Investigation
https://www.readbyqxmd.com/read/29614706/yoga-and-meditation-based-lifestyle-intervention-increases-neuroplasticity-and-reduces-severity-of-major-depressive-disorder-a-randomized-controlled-trial
#8
Madhuri R Tolahunase, Rajesh Sagar, Muneeb Faiq, Rima Dada
BACKGROUND: Current interventions for major depressive disorder (MDD) are suboptimal, and only one third respond to them on initial treatment. Neuroplasticity theories are the basis for several emerging treatments. Evidence on the impact of yoga, a well-known mind-body intervention, on neuroplasticity in MDD is limited. OBJECTIVES: To determine the effects of 12-week yoga- and meditation- based lifestyle intervention (YMLI) on depression severity and systemic biomarkers of neuroplasticity in adult MDD patients on routine drug treatment...
March 25, 2018: Restorative Neurology and Neuroscience
https://www.readbyqxmd.com/read/29611101/the-compensatory-immune-regulatory-reflex-system-cirs-in-depression-and-bipolar-disorder
#9
REVIEW
Michael Maes, Andre F Carvalho
Here, we review a novel concept namely the compensatory immune-regulatory reflex system (CIRS) as applied to the pathophysiology of major depressive disorder (MDD) and bipolar disorder (BD). There is evidence that a substantial subset of individuals with MDD and BD exhibit an activation of the immune-inflammatory response system (IRS), as indicated by an increased production of macrophagic M1 and T helper (Th)-1 pro-inflammatory cytokines, interleukin (IL)-6 trans-signaling, positive acute phase proteins (APPs), and complement factors...
April 2, 2018: Molecular Neurobiology
https://www.readbyqxmd.com/read/29608925/transdiagnostic-and-diagnosis-specific-dynamic-functional-connectivity-anchored-in-the-right-anterior-insula-in-major-depressive-disorder-and-bipolar-depression
#10
Yajing Pang, Heng Chen, Yifeng Wang, Zhiliang Long, Zongling He, Huangbin Zhang, Wei Liao, Qian Cui, Huafu Chen
Dysfunctional and abnormal functional connectivity in the right anterior insula (rAI) may underlie the pathophysiology of depression episode in bipolar disorder (BD) and of major depressive disorder (MDD). In this study, we examined the dynamic functional connectivity (dFC) of the rAI of 30 patients with BD, 30 patients with MDD, and 30 healthy controls. In the functional separation of rAI, the right dorsal AI (rdAI) and ventral AI (rvAI) were defined as seed regions. Sliding-window correlation of rAI subregions was implemented to measure the variance of dFC...
March 30, 2018: Progress in Neuro-psychopharmacology & Biological Psychiatry
https://www.readbyqxmd.com/read/29595146/assessment-of-linear-and-nonlinear-complex-heartbeat-dynamics-in-subclinical-depression-dysphoria
#11
Alberto Greco, Simone Messerotti Benvenuti, Claudio Gentili, Daniela Palomba, Enzo Pasquale Scilingo, Gaetano Valenza
OBJECTIVE: Depression is one of the leading causes of disability worldwide. Most previous studies have focused on major depression, and studies on subclinical depression, such as those on so-called dysphoria, have been overlooked. Indeed, dysphoria is associated with a high prevalence of somatic disorders, and a reduction of quality of life and life expectancy. In current clinical practice, dysphoria is assessed using psychometric questionnaires and structured interviews only, without taking into account objective pathophysiological indices...
March 29, 2018: Physiological Measurement
https://www.readbyqxmd.com/read/29575563/orbito-frontal-cortex-mechanism-of-inhibition-of-return-in-current-and-remitted-depression
#12
Qin Dai, Xuntao Yin, Hong Li, Zhengzhi Feng
Deficient inhibition of return (IOR) for emotional materials is an important cognitive biomarker of depression. However, its neural mechanism and role in depression remission remain largely unknown. Using functional magnetic resonance imaging (fMRI), this study observed the neural foundation of inhibition of return in individuals with current (n = 30) and remitted (n = 27) depression and in healthy controls (n = 33), by using a cue-target task. The results showed that individuals with remitted depression (RMD) possessed a nonavoidant attention model for sad faces, which indicated a cue validity and was correlated with enhanced task- and resting-state activation and function connectivity in orbitofrontal cortex (OFC)...
March 25, 2018: Human Brain Mapping
https://www.readbyqxmd.com/read/29575228/herbal-medicines-in-the-treatment-of-psychiatric-disorders-10-year-updated-review
#13
REVIEW
Jerome Sarris
This paper provides a 10-year update of the 2007 systematic review of herbal medicines studied in a broad range of psychiatric disorders, including depression, anxiety, obsessive-compulsive, seasonal affective, bipolar, psychotic, phobic, somatoform, and attention-deficit hyperactivity disorders. Ovid Medline, PubMed, and the Cochrane Library were searched for herbal medicines with both pharmacological and clinical evidence of psychotropic activity. This updated review now covers clinical trial evidence for 24 herbal medicines in 11 psychiatric disorders...
March 25, 2018: Phytotherapy Research: PTR
https://www.readbyqxmd.com/read/29569983/the-development-of-a-novel-high-precision-major-depressive-disorder-screening-system-using-transient-autonomic-responses-induced-by-dual-mental-tasks
#14
Takemi Matsui, Toshikazu Shinba, Guanghao Sun
12.6% of major depressive disorder (MDD) patients have suicide intent, while it has been reported that 43% of patients did not consult their doctors for MDD, automated MDD screening is eagerly anticipated. Recently, in order to achieve automated screening of MDD, biomarkers such as multiplex DNA methylation profiles or physiological method using near infra-red spectroscopy (NIRS) have been studied, however, they require inspection using 96-well DNA ELIZA kit after blood sampling or significant cost. Using a single-lead electrocardiography (ECG), we developed a high-precision MDD screening system using transient autonomic responses induced by dual mental tasks...
March 23, 2018: Journal of Medical Engineering & Technology
https://www.readbyqxmd.com/read/29559928/exercise-leads-to-better-clinical-outcomes-in-those-receiving-medication-plus-cognitive-behavioral-therapy-for-major-depressive-disorder
#15
Joanne Gourgouvelis, Paul Yielder, Sandra T Clarke, Hushyar Behbahani, Bernadette Ann Murphy
Objective: The aim of this study is to investigate the effects of exercise as an add-on therapy with antidepressant medication and cognitive behavioral group therapy (CBGT) on treatment outcomes in low-active major depressive disorder (MDD) patients. We also explored whether exercise reduces the residual symptoms of depression, notably cognitive impairment and poor sleep quality, and aimed to identify putative biochemical markers related to treatment response. Methods: Sixteen low-active MDD patients were recruited from a mental health day treatment program at a local hospital...
2018: Frontiers in Psychiatry
https://www.readbyqxmd.com/read/29547816/abnormal-emotional-and-neural-responses-to-romantic-rejection-and-acceptance-in-depressed-women
#16
Ashley A Yttredahl, Erin McRobert, Benjamin Sheler, Brian J Mickey, Tiffany M Love, Scott A Langenecker, Jon-Kar Zubieta, David T Hsu
INTRODUCTION: Responding adaptively to one's social environment is a key factor predicting the course of major depressive disorder (MDD). Socially rejecting events can exacerbate, whereas socially accepting events can ameliorate depressive symptoms. The neural responses to rejection and acceptance in MDD are relatively unexplored. METHODS: We used functional magnetic resonance imaging (fMRI) to measure neural responses to romantic rejection and acceptance in women diagnosed with current MDD (n = 19) and a matched group of healthy controls (HCs) (n = 19)...
July 2018: Journal of Affective Disorders
https://www.readbyqxmd.com/read/29547392/visceral-adipose-tissue-in-patients-with-severe-mental-illness
#17
REVIEW
Kai G Kahl, Michael Deuschle, Brendon Stubbs, Ulrich Schweiger
Background Severe mental illnesses (SMIs), i.e. major depression, schizophrenia and bipolar disorder, are associated with an elevated risk for the development of type-2 diabetes mellitus and cardiovascular disorders. Several factors have been associated with increased cardiometabolic morbidity and mortality in SMI, including lifestyle factors (smoking, inactivity, unhealthy diet), endocrine and immunologic alterations; however, the underlying mechanisms remain to be fully uncovered. It is now well accepted that visceral adipose tissue (VAT) promotes the development of cardiometabolic disorders, at least in part by inflammatory and metabolic functions...
March 16, 2018: Hormone Molecular Biology and Clinical Investigation
https://www.readbyqxmd.com/read/29545905/s100b-homocysteine-vitamin-b12-folic-acid-and-procalcitonin-serum-levels-in-remitters-to-electroconvulsive-therapy-a-pilot-study
#18
Hannah Maier, Saskia Helm, Sermin Toto, Nicole Moschny, Wolfgang Sperling, Thomas Hillemacher, Kai G Kahl, Ewgeni Jakubovski, Stefan Bleich, Helge Frieling, Alexandra Neyazi
Background: Electroconvulsive therapy (ECT) is one of the most effective treatment options for refractory depressed patients. To date, there are only a few predictors of response. Aim: The aim was to identify predictive biomarkers of remission to ECT on a molecular level. Methods: 11 patients suffering from a major depressive episode-according to the Statistical Manual of Mental Disorders, Fourth Edition (DSM-IV)-underwent 10 ECT sessions...
2018: Disease Markers
https://www.readbyqxmd.com/read/29535038/neutrophil-lymphocyte-ratio-and-platelet-lymphocyte-ratio-in-mood-disorders-a-meta-analysis
#19
REVIEW
Mario Gennaro Mazza, Sara Lucchi, Agnese Grazia Maria Tringali, Aurora Rossetti, Eugenia Rossana Botti, Massimo Clerici
The immune and inflammatory system is involved in the etiology of mood disorders. Neutrophil/lymphocyte ratio (NLR), platelet/lymphocyte ratio (PLR) and monocyte/lymphocyte ratio (MLR) are inexpensive and reproducible biomarkers of inflammation. This is the first meta-analysis exploring the role of NLR and PLR in mood disorder. We identified 11 studies according to our inclusion criteria from the main Electronic Databases. Meta-analyses were carried out generating pooled standardized mean differences (SMDs) between index and healthy controls (HC)...
March 10, 2018: Progress in Neuro-psychopharmacology & Biological Psychiatry
https://www.readbyqxmd.com/read/29531242/bipolar-disorder-in-youth-is-associated-with-increased-levels-of-vitamin-d-binding-protein
#20
Brawnie Petrov, Ayat Aldoori, Cindy James, Kefeng Yang, Guillermo Perez Algorta, Aejin Lee, Liwen Zhang, Tao Lin, Reem Al Awadhi, Jonathan R Parquette, Arpad Samogyi, L Eugene Arnold, Mary A Fristad, Barbara Gracious, Ouliana Ziouzenkova
Genetic, dietary, and inflammatory factors contribute to the etiology of major mood disorders (MMD), thus impeding the identification of specific biomarkers to assist in diagnosis and treatment. We tested association of vitamin D and inflammatory markers in 36 adolescents with bipolar disorder (BD) and major depressive disorder (MDD) forms of MMD and without MMD (non-mood control). We also assessed the overall level of inflammation using a cell-based reporter assay for nuclear factor kappa-B (NFκB) activation and measuring antibodies to oxidized LDL...
March 13, 2018: Translational Psychiatry
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