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https://www.readbyqxmd.com/read/28102941/synthesis-of-primaquine-glyco-conjugates-as-potential-tissue-schizontocidal-antimalarial-agents
#1
Chandra S Azad, Mridula Saxena, Arif J Siddiqui, Jyoti Bhardwaj, Sunil K Puri, Guru P Dutta, Nity Anand, Anil K Saxena
Primaquine (PQ) is the only drug used to prevent relapse of malaria due to P. vivax and P. ovale, by eradicating the dormant liver form of the parasite (hypnozoites). The side effects associated with PQ limits is uses in treatment of malaria. To overcome the premature oxidative deamination and to increase the life span of drug in the biological system the novel glyco-conjugates of PQ were synthesized by coupling of primaquine with hexoses in phosphate buffer. The saccharide part of the hybrid molecules thought to be direct the drug to the liver, where hypnozoites resides...
January 19, 2017: Chemical Biology & Drug Design
https://www.readbyqxmd.com/read/28101612/abolishment-of-n-glycan-mannosylphosphorylation-in-glyco-engineered-saccharomyces-cerevisiae-by-double-disruption-of-mnn4-and-mnn14-genes
#2
Yeong Hun Kim, Ji-Yeon Kang, Jin Young Gil, Sang-Yoon Kim, Keun Koo Shin, Hyun Ah Kang, Jeong-Yoon Kim, Ohsuk Kwon, Doo-Byoung Oh
Mannosylphosphorylated glycans are found only in fungi, including yeast, and the elimination of mannosylphosphates from glycans is a prerequisite for yeast glyco-engineering to produce human-compatible glycoproteins. In Saccharomyces cerevisiae, MNN4 and MNN6 genes are known to play roles in mannosylphosphorylation, but disruption of these genes does not completely remove the mannosylphosphates in N-glycans. This study was performed to find unknown key gene(s) involved in N-glycan mannosylphosphorylation in S...
January 18, 2017: Applied Microbiology and Biotechnology
https://www.readbyqxmd.com/read/28092404/metformin-versus-myoinositol-which-is-better-in-obese-pcos-patients-a-randomized-controlled-crossover-study
#3
Valeria Tagliaferri, Daniela Romualdi, Valentina Immediata, Simona De Cicco, Christian Di Florio, Antonio Lanzone, Maurizio Guido
CONTEXT: due to the central role of metabolic abnormalities in the pathophysiology of PCOS, insulin sensitising agents have been proposed as a feasible treatment option. OBJECTIVE: to investigate which is the more effective between metformin and myoinositol on hormonal, clinical and metabolic parameters in obese patients with polycystic ovary syndrome (PCOS). STUDY DESIGN: crossover randomized-controlled study. PATIENTS: Thirty-four PCOS obese women (age: 25...
January 16, 2017: Clinical Endocrinology
https://www.readbyqxmd.com/read/28078490/podocalyxin-as-a-major-pluripotent-marker-and-novel-keratan-sulfate-proteoglycan-in-human-embryonic-and-induced-pluripotent-stem-cells
#4
REVIEW
Hidenao Toyoda, Yuko Nagai, Aya Kojima, Akiko Kinoshita-Toyoda
Podocalyxin (PC) was first identified as a heavily sialylated transmembrane protein of glomerular podocytes. Recent studies suggest that PC is a remarkable glycoconjugate that acts as a universal glyco-carrier. The glycoforms of PC are responsible for multiple functions in normal tissue, human cancer cells, human embryonic stem cells (hESCs), and human induced pluripotent stem cells (hiPSCs). PC is employed as a major pluripotent marker of hESCs and hiPSCs. Among the general antibodies for human PC, TRA-1-60 and TRA-1-81 recognize the keratan sulfate (KS)-related structures...
January 11, 2017: Glycoconjugate Journal
https://www.readbyqxmd.com/read/28075053/synthesis-characterization-and-immunological-evaluation-of-self-adjuvanting-group-a-streptococcal-vaccine-candidates-bearing-various-lipidic-adjuvanting-moieties
#5
Vincent Fagan, Waleed M Hussein, Mei Su, Ashwini K Gidda, Michael R Batzloff, Michael F Good, Istvan Toth, Pavla Simerska
Four group A streptococcal glyco-lipopeptide vaccine candidates were prepared and characterized, each possessing different lipidic adjuvanting moieties. The immunogenicity of the compounds was evaluated by macrophage and dendritic cell uptake studies and by in vivo quantification of systemic IgG antibody using ELISA. Three of the four vaccine candidates showed a significant induction of IgG response compared to a negative control.
January 11, 2017: Chembiochem: a European Journal of Chemical Biology
https://www.readbyqxmd.com/read/28057734/glyco-forum
#6
EDITORIAL
(no author information available yet)
No abstract text is available yet for this article.
January 2017: Glycobiology
https://www.readbyqxmd.com/read/28031294/glyco-forum
#7
EDITORIAL
(no author information available yet)
No abstract text is available yet for this article.
January 2017: Glycobiology
https://www.readbyqxmd.com/read/28009977/glycan-microarray-reveal-the-sweet-side-of-cancer-vaccines
#8
Vered Padler-Karavani
Advances in genomics and bioinformatics facilitated identification of tumor-specific neoantigens as optimal targets for cancer immunotherapy. In this hot topic, most efforts focus on mutant peptide antigens, overlooking tumor-associated glycosylation changes. Given the latest progress in glycomics, in this issue of Cell Chemical Biology, Xia et al. (2016) use glyco-antigen microarrays to investigate immune responses to whole cancer vaccines and provide important insights into vaccine efficacy.
December 22, 2016: Cell Chemical Biology
https://www.readbyqxmd.com/read/28007619/malignant-mesothelioma-biomarkers-from-discovery-to-use-in-clinical-practise-for-diagnosis-monitoring-screening-and-treatment
#9
REVIEW
Jenette Creaney, Bruce W S Robinson
Malignant pleural mesothelioma is a highly aggressive tumour associated with asbestos exposure. There are few effective treatment options for mesothelioma and patients have a very poor prognosis with a median survival of less than 12 months from diagnosis. Biomarkers have been proposed as a cost-effective means of cancer management and the search for a mesothelioma biomarker has been on-going for the past thirty years. Many traditional soluble (glyco)-protein biomarkers have been evaluated over this time and an ever increasing list of new biomarkers, including mRNA, DNA, miRNA and antibodies, are being reported from biomarker discovery projects...
December 19, 2016: Chest
https://www.readbyqxmd.com/read/28003855/activation-of-ice-recrystallization-inhibition-activity-of-poly-vinyl-alcohol-using-a-supramolecular-trigger
#10
Daniel J Phillips, Thomas R Congdon, Matthew I Gibson
Antifreeze (glyco)proteins (AF(G)Ps) have potent ice recrystallisation inhibition (IRI) activity - a desirable phenomenon in applications such as cryopreservation, frozen food and more. In Nature AF(G)P activity is regulated by protein expression levels in response to an environmental stimulus; temperature. However, this level of regulation is not possible in synthetic systems. Here, a synthetic macromolecular mimic is introduced, using supramolecular assembly to regulate activity. Catechol-terminated poly(vinyl alcohol) was synthesised by RAFT polymerization...
March 7, 2016: Polymer Chemistry
https://www.readbyqxmd.com/read/27984693/global-n-glycan-site-occupancy-of-hiv-1-gp120-by-metabolic-engineering-and-high-resolution-intact-mass-spectrometry
#11
Weston B Struwe, Alexandra Stuckmann, Anna-Janina Behrens, Kevin Pagel, Max Crispin
A vital step in HIV vaccine development strategies has been the observation that some infected individuals generate broadly neutralizing antibodies that target the glycans on the surface of HIV-1 gp120. These antibodies target glycan epitopes on viral envelope spikes, and yet the positions and degree of occupancy of glycosylation sites is diverse. Therefore, there is a need to understand glycosylation occupancy on recombinant immunogens. The sheer number of potential glycosylation sites and degree of chemical heterogeneity impedes assessing the global sequon occupancy of gp120 glycoforms...
January 9, 2017: ACS Chemical Biology
https://www.readbyqxmd.com/read/27984039/glycolipids-and-lectins-in-endocytic-uptake-processes
#12
REVIEW
Ludger Johannes, Christian Wunder, Massiullah Shafaq-Zadah
A host of endocytic processes has been described at the plasma membrane of eukaryotic cells. Their categorization has most commonly referenced cytosolic machinery, of which the clathrin coat has occupied a preponderant position. In what concerns intra-membrane constituents, the focus of interest has been on phosphatidylinositol lipids and their capacity to orchestrate endocytic events on the cytosolic leaflet of the membrane. The contribution of extracellular determinants to the construction of endocytic pits has received much less attention, depite the fact that (glyco)sphingolipids are exoplasmic leaflet fabric of membrane domains, termed rafts, whose contributions to predominantly clathrin-independent internalization processes is well recognized...
October 27, 2016: Journal of Molecular Biology
https://www.readbyqxmd.com/read/27957777/photoinduced-thiol-ene-chemistry-applied-to-the-synthesis-of-elastin-inspired-self-assembling-glycopeptides
#13
Germano Piccirillo, Antonietta Pepe, Emiliano Bedini, Brigida Bochicchio
Synthetic (glyco-)peptides inspired by proteins able to self-assemble are appealing biomaterials in the field of tissue engineering and regenerative medicine. Herein for the first time, taking advantage of thiol-ene chemistry coupled to Solid Phase Peptide Synthesis, a self-assembling peptide inspired by elastin protein was bioconjugated to three carbohydrates in order to obtain the corresponding glycopeptides. They were studied at molecular and supramolecular level. The results show that the carbohydrate influences the molecular conformation of the glycopeptide and its self-aggregation properties as well...
December 13, 2016: Chemistry: a European Journal
https://www.readbyqxmd.com/read/27940408/carbohydrate-structure-the-rocky-road-to-automation
#14
REVIEW
Jon Agirre, Gideon J Davies, Keith S Wilson, Kevin D Cowtan
With the introduction of intuitive graphical software, structural biologists who are not experts in crystallography are now able to build complete protein or nucleic acid models rapidly. In contrast, carbohydrates are in a wholly different situation: scant automation exists, with manual building attempts being sometimes toppled by incorrect dictionaries or refinement problems. Sugars are the most stereochemically complex family of biomolecules and, as pyranose rings, have clear conformational preferences. Despite this, all refinement programs may produce high-energy conformations at medium to low resolution, without any support from the electron density...
December 8, 2016: Current Opinion in Structural Biology
https://www.readbyqxmd.com/read/27930742/analysis-of-domain-architecture-and-phylogenetics-of-family-2-glycoside-hydrolases-gh2
#15
David Talens-Perales, Anna Górska, Daniel H Huson, Julio Polaina, Julia Marín-Navarro
In this work we report a detailed analysis of the topology and phylogenetics of family 2 glycoside hydrolases (GH2). We distinguish five topologies or domain architectures based on the presence and distribution of protein domains defined in Pfam and Interpro databases. All of them share a central TIM barrel (catalytic module) with two β-sandwich domains (non-catalytic) at the N-terminal end, but differ in the occurrence and nature of additional non-catalytic modules at the C-terminal region. Phylogenetic analysis was based on the sequence of the Pfam Glyco_hydro_2_C catalytic module present in most GH2 proteins...
2016: PloS One
https://www.readbyqxmd.com/read/27930505/increased-membrane-localization-of-pannexin1-in-human-corneal-synaptosomes-causes-enhanced-stimulated-atp-release-in-chronic-diabetes-mellitus
#16
Hao Cui, Ying Liu, Limin Qin, Liqiang Wang, Yifei Huang
In the present study, we investigated the potential changes in the corneal nerve terminals in non-insulin-dependent diabetes mellitus of moderate duration. The dissected corneas were subjected to a protocol of ultracentrifugation to obtain synaptosomes of sensory nerve terminals. Within these nerve varicosities, 2 major mechanisms were examined, viz., alterations of the mechanosensitive channel pannexin1 and ATP release on stimulation of these terminals. We hypothesized that altered cellular location and function of the pannexin channel may contribute to altered mechanosensitivity of the cornea, which in turn may affect wound healing and primary visual function of the cornea...
December 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27920124/glyco-forum
#17
EDITORIAL
(no author information available yet)
No abstract text is available yet for this article.
December 2016: Glycobiology
https://www.readbyqxmd.com/read/27919172/influence-of-glyco-oxidation-on-complexes-between-fibrin-ogen-and-insulin-like-growth-factor-binding-protein-1-in-patients-with-diabetes-mellitus-type-2
#18
Nikola Gligorijević, Ana Penezić, Olgica Nedić
Fibrinogen and insulin-like growth factor-binding protein (IGFBP-1) are tightly connected to metabolic changes and complications in patients with diabetes mellitus (DM), and since they mutually interact to form complexes in plasma, we investigated whether and to what extent IGFBP-1/fibrinogen complexes change due to glyco-oxidative processes in DM and whether they participate in fibrin clot formation. These complexes were determined by immunoblotting in plasma samples from healthy adults and patients with DM type 2...
December 5, 2016: Free Radical Research
https://www.readbyqxmd.com/read/27900782/residue-centric-modeling-and-design-of-saccharide-and-glycoconjugate-structures
#19
Jason W Labonte, Jared Adolf-Bryfogle, William R Schief, Jeffrey J Gray
The RosettaCarbohydrate framework is a new tool for modeling a wide variety of saccharide and glycoconjugate structures. This report describes the development of the framework and highlights its applications. The framework integrates with established protocols within the Rosetta modeling and design suite, and it handles the vast complexity and variety of carbohydrate molecules, including branching and sugar modifications. To address challenges of sampling and scoring, RosettaCarbohydrate can sample glycosidic bonds, side-chain conformations, and ring forms, and it utilizes a glycan-specific term within its scoring function...
February 15, 2017: Journal of Computational Chemistry
https://www.readbyqxmd.com/read/27889407/whole-cell-cancer-vaccines-induce-large-antibody-responses-to-carbohydrates-and-glycoproteins
#20
Li Xia, David S Schrump, Jeffrey C Gildersleeve
Whole-cell cancer vaccines are a promising strategy for treating cancer, but the characteristics of a favorable immune response are not fully understood. New insights could enable development of better vaccines, discovery of new antigens, and identification of biomarkers of efficacy. Using glyco-antigen microarrays, we demonstrate that GVAX Pancreas (a granulocyte macrophage colony-stimulating factor-modified whole-cell tumor vaccine) induces large immunoglobulin G and immunoglobulin M responses to many antigens, including tumor-associated carbohydrates, blood group antigens, α-Gal, and bovine fetuin...
December 22, 2016: Cell Chemical Biology
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