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D Busbee, R Barhoumi, R C Burghardt, C Gauntt, B McAnalley, H R McDaniel
A complex glyconutritional (GN) mixture of mono-, di-and polysaccharides was investigated to assess its capacity to protect two different types of rodent cells, rat hepatocytes and mouse splenocytes, from depletion of glutathione by a sulfhydryl-reactive mycotoxin, patulin, or by coxsackievirus B3 (CVB3) infection, respectively. Rat hepatocytes were treated with the GN mixture in vitro or received carrier medium only prior to treatment with patulin. When treated with the GN mixture prior to patulin exposure hepatocytes demonstrated protection against depletion of intracellular reduced glutathione (GSH)...
October 1999: Age (1978-1999)
C Gauntt, D Busbee, H J Wood, S Reyna, R Barhoumi, R Burghardt, W McAnalley, H R McDaniel
Challenge of adolescent male CD-1 mice with a coxsackievirus B3 (CVB3) strain (CVB3m) induces mild to severe destruction of pancreatic acinar cells, but causes no deaths and does not induce hyperglycemia. A weekly parenteral (intraperitoneal) administration of a glyconutritional mixture (Ambrotose® to virus-challenged mice was assessed to determine if there were any benefits to recovery over an eight month period. Virus-challenged mice showed a significant weight loss over the initial five weeks of the experiment, but injection of Ambrotose® to similar virus-challenged mice restored the total body weight to levels found in normal mice...
October 1999: Age (1978-1999)
Atiya N Stancil, Leslie H Hicks
Neuropsychological tests were administered to 62 college students to assess the influence of glyconutrients on perception, cognition and memory in two randomized, double-blind, placebo-controlled, counterbalanced studies. Participants were given both a glyconutritional supplement and a control substance prior to testing. In Exp. 1. a Same-Different visual discrimination task, Raven's Standard Progressive Matrices, and the Stroop test were administered. In Exp. 2, simple and complex working-memory capacity were measured...
February 2009: Perceptual and Motor Skills
Alexis R Eberendu, Christy Booth, Gabriela Luta, Joshua A Edwards, Bill H McAnalley
A new technique for the assay of carbohydrates is described in which separation and quantification of neutral saccharides, aminosaccharides, glycuronic acids, and disaccharides may be accomplished in less than 50 min of total run time. This method involves optimized anion-exchange liquid chromatography coupled with integrated pulse amperometric detection. Complex carbohydrates from various sources, including dietary supplements, were hydrolyzed in a dilute solution of trifluoroacetic acid, freeze-dried, and reconstituted in water containing 2-deoxygalactose as the internal standard...
July 2005: Journal of AOAC International
Chenghua Wang, Joanne S Szabo, Roscoe A Dykman
Glucose is a major energy source for the brain, and along with several monosaccharide derivatives as components of brain gangliosides, they play important roles in neurologic function. However, there is little information available on the role of glucose and other monosaccharides on resting brain activity. This study was designed to evaluate the effects of a single dose of a carbohydrate supplement containing glucose and several of its derivatives on resting brain activity in 20 healthy male college students...
April 2004: Integrative Physiological and Behavioral Science: the Official Journal of the Pavlovian Society
K D Dykman, R A Dykman
This study reports the effects of two nutritional products upon the severity of symptoms in children with confirmed diagnoses of Attention-Deficit Hyperactivity Disorder (ADHD): a glyconutritional product containing saccharides known to be important in healthy functioning and a phytonutritional product containing flash-dried fruits and vegetables. Seventeen ADHD children were recruited from a local parent support group. Parents of five of the subjects did not have their children on methylphenidate. Of the remaining twelve, all on methylphenidate, six were left on prescribed doses (random assignment)...
January 1998: Integrative Physiological and Behavioral Science: the Official Journal of the Pavlovian Society
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