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https://www.readbyqxmd.com/read/28095969/body-fat-distribution-ratios-and-obstructive-sleep-apnea-severity-in-youth-with-obesity
#1
Amy Glicksman, Stasia Hadjiyannakis, Nicholas Barrowman, Scott Walker, Lynda Hoey, Sherri Lynne Katz
STUDY OBJECTIVES: Obesity and regional fat distribution, measured by neck fat mass percentage using dual-energy X-ray absorptiometry (DXA), correlate with obstructive sleep apnea (OSA) severity in adults. In obese children, neck-to-waist-circumference ratio predicts OSA. This study examined associations between body fat percentage and distribution and sleep-disordered breathing (SDB) severity in obese youth, measured with DXA. METHODS: Cross-sectional retrospective study conducted at a tertiary children's hospital...
January 11, 2017: Journal of Clinical Sleep Medicine: JCSM: Official Publication of the American Academy of Sleep Medicine
https://www.readbyqxmd.com/read/28092114/sleep-disordered-breathing-in-pediatric-head-and-neck-vascular-malformations
#2
Megan L Durr, Anna K Meyer, Eric J Kezirian, Mark D Mamlouk, Ilona J Frieden, Kristina W Rosbe
OBJECTIVES: To determine the prevalence of sleep-disordered breathing (SDB) symptoms among children with head and neck vascular malformations and to compare obstructive sleep apnea (OSA)-18 scores between children with head and neck vascular malformations and children with non-head and neck vascular malformations. STUDY DESIGN: Retrospective cohort and prospective cross-sectional studies METHODS: Forty-three pediatric subjects with head and neck vascular malformations evaluated at a tertiary-care multidisciplinary vascular anomalies center were included in a retrospective cohort study...
January 16, 2017: Laryngoscope
https://www.readbyqxmd.com/read/28087550/trends-and-changes-in-paediatric-tonsil-surgery-in-sweden-1987-2013-a-population-based-cohort-study
#3
Anna Borgström, Pia Nerfeldt, Danielle Friberg, Ola Sunnergren, Joacim Stalfors
OBJECTIVES: The objective of this study was to longitudinally describe the history of tonsil surgery in Swedish children and adolescents regarding incidence, indications for surgery, surgical methods and the age and gender distributions. SETTING: A retrospective longitudinal population-based cohort study based on register data from the Swedish National Patient Register (NPR) and population data from Statistics Sweden. PARTICIPANTS: All Swedish children 1-<18 years registered in the NPR with a tonsil surgery procedure 1987-2013...
January 13, 2017: BMJ Open
https://www.readbyqxmd.com/read/28081171/a-higher-proportion-of-metabolic-syndrome-in-chinese-subjects-with-sleep-disordered-breathing-a-case-control-study-based-on-electrocardiogram-derived-sleep-analysis
#4
Ping-Huei Tseng, Pei-Lin Lee, Wei-Chung Hsu, Yan Ma, Yi-Chia Lee, Han-Mo Chiu, Yi-Lwun Ho, Ming-Fong Chen, Ming-Shiang Wu, Chung-Kang Peng
OBJECTIVE: The prevalence of metabolic syndrome (MS) has increased rapidly in Taiwan and worldwide. We aim to determine the association between sleep-disordered breathing (SDB) and MS in a Chinese general population. METHODS: This case-control study recruited subjects who have undergone a prospective electrocardiogram-based cardiopulmonary coupling (CPC) sleep spectrogram as part of the periodic health check-ups at the National Taiwan University Hospital. Comprehensive anthropometrics, blood biochemistry, prevalence of MS and its individual components were compared with Bonferroni correction between 40 subjects with SDB, defined as the CPC-derived apnea-hypopnea index (CPC-AHI) >5 event/hour and 80 age- and sex-matched controls, defined as CPC-AHI <1 event/hour...
2017: PloS One
https://www.readbyqxmd.com/read/28073058/surface-engineering-of-pamam-sdb-chelating-resin-with-diglycolamic-acid-dga-functional-group-for-efficient-sorption-of-u-vi-and-th-iv-from-aqueous-medium
#5
P Ilaiyaraja, A K Singha Deb, D Ponraju, Sk Musharaf Ali, B Venkatraman
A novel chelating resin obtained via growth of PAMAM dendron on surface of styrene divinyl benzene resin beads, followed by diglycolamic acid functionalization of the dendrimer terminal. Batch experiments were conducted to study the effects of pH, nitric acid concentration, amount of adsorbent, shaking time, initial metal ion concentration and temperature on U(VI) and Th(IV) adsorption efficiency. Diglycolamic acid terminated PAMAM dendrimer functionalized styrene divinylbenzene chelating resin (DGA-PAMAM-SDB) is found to be an efficient candidate for the removal of U(VI) and Th(IV) ions from aqueous (pH >4) and nitric acid media (>3M)...
January 3, 2017: Journal of Hazardous Materials
https://www.readbyqxmd.com/read/28069061/association-between-physical-activity-and-sleep-disordered-breathing-in-male-japanese-workers-a-cross-sectional-study
#6
Hiroaki Itoh, Kazuhito Yokoyama, Takehisa Matsukawa, Fumihiko Kitamura
BACKGROUND: Whether physical activity reduces the risk of sleep-disordered breathing (SDB) for non-obese people remains unclear. The present cross-sectional study examined the association between physical activity and SDB among non-obese male Japanese workers. METHODS: All 200 workers in a company in Tokyo, Japan, who drove a motor vehicle as part of their job, were invited to be screened for SDB to prevent traffic accidents. Of these, 195 agreed to participate in this study...
January 9, 2017: BMC Research Notes
https://www.readbyqxmd.com/read/28068279/identifying-predictors-of-central-sleep-apnea-cheyne-stokes-breathing-in-chronic-heart-failure-a-pathophysiological-approach
#7
Aneliya I Draganova, Kiril V Terziyski, Stefan S Kostianev
Chronic heart failure (CHF) is a major health problem associated with increased mortality, despite modern treatment options. Central sleep apnea (CSA)/Cheyne-Stokes breathing (CSB) is a common and yet largely under-diagnosed co-morbidity, adding significantly to the poor prognosis in CHF because of a number of acute and chronic effects, including intermittent hypoxia, sympathetic overactivation, disturbed sleep architecture and impaired physical tolerance. It is characterized by repetitive periods of crescendo-decrescendo ventilatory pattern, alternating with central apneas and hypopneas...
December 1, 2016: Folia Medica
https://www.readbyqxmd.com/read/28064432/validation-of-nosas-score-for-screening-of-sleep-disordered-breathing-in-a-multiethnic-asian-population
#8
Adeline Tan, Yueheng Hong, Linda W L Tan, Rob M van Dam, Yan Yi Cheung, Chi-Hang Lee
PURPOSE: The NoSAS score was developed to identify subjects at high risk of sleep-disordered breathing (SDB). We aimed to validate the NoSAS score in a multiethnic Asian cohort and compare its performance to the STOP-Bang and Berlin questionnaires. METHODS: A sample of 242 subjects selected from a population-based cohort in Singapore completed home-based sleep testing with an Embletta device (type 3 monitor). All subjects were given the STOP-Bang and Berlin questionnaires for self-administration prior to the sleep study...
January 7, 2017: Sleep & Breathing, Schlaf & Atmung
https://www.readbyqxmd.com/read/28060556/the-frequency-of-sleep-disordered-breathing-in-children-with-asthma-and-its-effects-on-asthma-control
#9
Tayfur Ginis, Fatih Alper Akcan, Murat Capanoglu, Muge Toyran, Refika Ersu, Can Naci Kocabas, Ersoy Civelek
BACKGROUND: The presence of sleep-disordered breathing (SDB) in children with asthma may cause difficult to control asthma. OBJECTIVES: The aim of this study was to determine the frequency of SDB in children with asthma, to evaluate its effects on asthma control and to assess the risk factors associated with the presence of SDB. METHODS: Parents of children who Sleep Questionnaire (PSQ) and the Childhood Asthma Control Test (C-ACT). Asthma control level was assessed according to Global Initiative for Asthma (GINA)...
January 6, 2017: Journal of Asthma: Official Journal of the Association for the Care of Asthma
https://www.readbyqxmd.com/read/28055285/sleep-disordered-breathing-is-associated-with-higher
#10
Peter D Ahiawodzi, Richard A Kerber, Kira C Taylor, Frank D Groves, Elizabeth O'Brien, Joachim H Ix, Jorge R Kizer, Luc Djoussé, Russell P Tracy, Anne B Newman, David S Siscovick, John Robbins, K Mukamal
CONTEXT: Carboxymethyl-lysine (CML) results from oxidative stress and has been linked to cardiovascular disease. OBJECTIVE: To investigate the association between sleep-disordered breathing (SDB) - a source of oxidative stress- and CML. MATERIALS AND METHODS: 1002 participants in the Cardiovascular Health Study (CHS) were studied. RESULTS: Women with SDB had significantly higher CML concentration compared with those without SDB (OR = 1...
January 5, 2017: Biomarkers: Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals
https://www.readbyqxmd.com/read/28041720/atrial-fibrillation-is-a-major-cause-of-stroke-in-apneic-patients-a-prospective-study
#11
M Poli, P Philip, J Taillard, S Debruxelles, P Renou, J M Orgogozo, F Rouanet, I Sibon
OBJECTIVES: Large prospective studies have established that sleep-disordered breathing (SDB) is associated with an increased incidence of cardiovascular and cerebrovascular diseases. Heterogeneous results have been published about SDB and ischaemic stroke mechanism. The aim of this study was to evaluate the relationship between poststroke apneic syndrome and stroke aetiologies according to the ASCO classification. METHODS: A total of 134 patients with acute ischaemic cerebrovascular events were prospectively included...
March 4, 2016: Sleep Medicine
https://www.readbyqxmd.com/read/28029756/when-and-why-to-treat-the-child-who-snores
#12
Hui-Leng Tan, Maria Luz Alonso Alvarez, Marina Tsaoussoglou, Silke Weber, Athanasios G Kaditis
Obstructive sleep-disordered breathing (SDB) can result in cardiovascular and neurocognitive morbidity as well as adversely affect behavior, growth, quality of life, and nocturnal continence. This article summarizes the latest evidence regarding the morbidity related to obstructive SDB, commenting on the impact of severity of obstruction, that is, the difference in effects seen of moderate to severe obstructive sleep apnea syndrome (OSAS) compared to those of mild OSAS or primary snoring. The impact of therapy is discussed, focusing on which children are likely to benefit from treatment interventions; namely those with moderate or severe OSAS irrespective of the presence of morbidity, children with mild OSAS with associated morbidity or predictors of SDB persistence such as obesity, and children with complex conditions accompanied by upper airway obstruction like craniosynostosis and Prader-Willi syndrome...
December 28, 2016: Pediatric Pulmonology
https://www.readbyqxmd.com/read/28029639/sleep-disordered-breathing-exacerbates-muscle-vasoconstriction-and-sympathetic-neural-activation-in-patients-with-systolic-heart-failure
#13
Denise M L Lobo, Patricia F Trevizan, Edgar Toschi-Dias, Patricia A Oliveira, Rafael B Piveta, Dirceu R Almeida, Charles Mady, Edimar A Bocchi, Geraldo Lorenzi-Filho, Holly R Middlekauff, Carlos E Negrão
BACKGROUND: Sleep-disordered breathing (SDB) is common in patients with heart failure (HF), and hypoxia and hypercapnia episodes activate chemoreceptors stimulating autonomic reflex responses. We tested the hypothesis that muscle vasoconstriction and muscle sympathetic nerve activity (MSNA) in response to hypoxia and hypercapnia would be more pronounced in patients with HF and SDB than in patients with HF without SDB (NoSBD). METHODS AND RESULTS: Ninety consecutive patients with HF, New York Heart Association functional class II-III, and left ventricular ejection fraction ≤40% were screened for the study...
November 2016: Circulation. Heart Failure
https://www.readbyqxmd.com/read/28017934/association-between-sleep-disordered-breathing-and-electrocardiographic-markers-of-atrial-abnormalities-the-mesa-study
#14
Younghoon Kwon, Jeffrey R Misialek, Daniel Duprez, Alvaro Alonso, David R Jacobs, Susan R Heckbert, Susan Redline, Elsayed Z Soliman
AIMS: Electrocardiographic (ECG) markers of left atrial (LA) abnormalities have been linked to increased risk of atrial fibrillation (AF). Sleep disordered breathing (SDB) has been associated with increased risk of AF. We aimed to examine the association of ECG markers of LA abnormalities with SDB. METHODS AND RESULTS: 1546 participants (mean age 67.2 years, 53.4% women, and 63.3% non-whites) from the Multi-Ethnic Study of Atherosclerosis Exam 5 Sleep ancillary study were included in this analysis...
December 25, 2016: Europace: European Pacing, Arrhythmias, and Cardiac Electrophysiology
https://www.readbyqxmd.com/read/28012067/the-gender-difference-of-snore-distribution-and-increased-tendency-to-snore-in-women-with-menopausal-syndrome-a-general-population-study
#15
Li-Pang Chuang, Shih-Wei Lin, Li-Ang Lee, Hsueh-Yu Li, Chih-Hao Chang, Kuo-Chin Kao, Li-Fu Li, Chung-Chi Huang, Cheng-Ta Yang, Ning-Hung Chen
PURPOSE: Sleep-disordered breathing (SDB) is a prevalent disorder with a major impact in women, especially postmenopausal women. However, few studies have investigated the prevalence of a specific SDB, snoring, among women especially those with menopausal syndrome. METHODS: Computer-assisted telephone interviews were conducted in Taiwan. Adults over 20 years of age were interviewed. The number of successful interviews was calculated based on the population prior to the study...
December 23, 2016: Sleep & Breathing, Schlaf & Atmung
https://www.readbyqxmd.com/read/27995120/tonsillectomy-as-prevention-and-treatment-of-sleep-disordered-breathing-a-report-of-23-cases
#16
Jae-Man Woo, Jin-Young Choi
BACKGROUND: The paradigm of tonsillectomy has shifted from a treatment of recurrent throat infection to one of multi-discipline management modalities of sleep-disordered breathing (SDB). While tonsillectomy as a treatment for throat problems has been performed almost exclusively by otorhinolaryngologists, tonsillectomy as a part of the armamentarium for the multifactorial, multidisciplinary therapy of sleep-disordered breathing needs a new introduction to those involved in treating SDB patients...
December 2016: Maxillofacial Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/27993515/cardiometabolic-risk-is-associated-with-the-severity-of-sleep-disordered-breathing-in-children-with-obesity
#17
Laurie Isacco, Johanna Roche, Sylvain Quinart, David Thivel, Valérie Gillet, Véronique Nègre, Fabienne Mougin
BACKGROUND: The alarming progression of pediatric obesity is associated with the development of sleep-disordered breathing (SDB), and both exhibit similar adverse cardiometabolic health outcomes. Physical activity level (PAL) may counteract sleep and metabolic disturbances. The present study investigates i) the association between the metabolic syndrome in childhood obesity and SDB, ii) the impact of SDB severity on cardiometabolic risk scores and PAL in children with obesity. METHODS: Maturation status (Tanner stages), anthropometric (height, weight, body mass index, waist circumference, body adiposity index) and cardiometabolic characteristics (systolic and diastolic blood pressure, lipid and glycemic profiles) were assessed in 83 obese children (mean±SD, age: 10...
December 16, 2016: Physiology & Behavior
https://www.readbyqxmd.com/read/27993286/pulse-transit-time-changes-in-subjects-exhibiting-sleep-disordered-breathing
#18
Biswajit Chakrabarti, Stephen Emegbo, Sonya Craig, Nick Duffy, John O'Reilly
INTRODUCTION: Pulse Transit Time (PTT) represents a non-invasive marker of sleep fragmentation in OSAS. Little is known regarding PTT in sleepy subjects exhibiting nocturnal Inspiratory Flow Limitation (IFL) in the absence of apneas or desaturation. MATERIALS AND METHODS: The IFL cohort was gender and age matched to subjects with OSAS and a cohort where Sleep Disordered Breathing (SBD)/IFL was absent ("Non Flow Limited" or NFL cohort); PTT Arousal index (PTT Ar) defined by number of PTT arousals per hour...
January 2017: Respiratory Medicine
https://www.readbyqxmd.com/read/27992566/the-accuracy-of-portable-monitoring-in-diagnosing-significant-sleep-disordered-breathing-in-hospitalized-patients
#19
Swamy Nagubadi, Rohit Mehta, Mamoun Abdoh, Mohammedumer Nagori, Stephen Littleton, Renaud Gueret, Aiman Tulaimat
BACKGROUND: Polysomnograms are not always feasible when sleep disordered breathing (SDB) is suspected in hospitalized patients. Portable monitoring is a practical alternative; however, it has not been recommended in patients with comorbidities. OBJECTIVE: We evaluated the accuracy of portable monitoring in hospitalized patients suspected of having SDB. DESIGN: Prospective observational study. SETTING: Large, public, urban, teaching hospital in the United States...
2016: PloS One
https://www.readbyqxmd.com/read/27965436/an-interview-with-doug-melton
#20
Aidan Maartens
Doug Melton is Xander University Professor at Harvard University, co-director of the Harvard Stem Cell Institute and a Howard Hughes Medical Institute Investigator. His lab investigates the development of the pancreas, and uses insights from this process to direct the production of insulin-producing beta cells from stem cells. We met Doug at the 2016 Society for Developmental Biology-International Society of Differentiation (SDB-ISD) joint meeting in Boston, USA, where he gave the Jean Brachet Lecture.
December 15, 2016: Development
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