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https://www.readbyqxmd.com/read/28934528/the-impact-of-altitude-on-sleep-disordered-breathing-in-children-dwelling-at-high-altitude-a-crossover-study
#1
Benjamin H Hughes, John T Brinton, David G Ingram, Ann C Halbower
Study Objectives: Sleep-disordered breathing (SDB) is prevalent among children and is associated with adverse health outcomes. Worldwide, approximately 250 million individuals reside at altitudes higher than 2000 meters above sea level (masl). The effect of chronic high-altitude exposure on children with SDB is unknown. This study aims to determine the impact of altitude on sleep study outcomes in children with SDB dwelling at high altitude. Methods: A single-center crossover study was performed to compare results of high-altitude home polysomnography (H-PSG) with lower altitude laboratory polysomnography (L-PSG) in school-age children dwelling at high altitude with symptoms consistent with SDB...
September 1, 2017: Sleep
https://www.readbyqxmd.com/read/28924264/neurocognitive-and-behavioral-functioning-in-adolescents-with-sleep-disordered-breathing-a-population-based-dual-energy-x-ray-absorptiometry-study
#2
S S Frye, J Fernandez-Mendoza, S L Calhoun, J Gaines, M D Sawyer, F He, D Liao, A N Vgontzas, E O Bixler
BACKGROUND/OBJECTIVES: Sleep disordered breathing (SDB) has been associated with neurocognitive and behavioral problems in young children; however, this association is less studied in adolescents. Evidence suggests that obesity plays a key role in the development of SDB, although its relative association with neurobehavioral functioning remains unclear. We examined whether SDB and obesity are associated with neurocognitive and behavior problems in adolescents. SUBJECTS/METHODS: 421 adolescents (17...
September 19, 2017: International Journal of Obesity: Journal of the International Association for the Study of Obesity
https://www.readbyqxmd.com/read/28923022/the-association-of-sleep-disordered-breathing-with-left-ventricular-remodeling-in-cad-patients-a-cross-sectional-study
#3
Audrius Alonderis, Nijole Raskauskiene, Vaidute Gelziniene, Narseta Mickuviene, Julija Brozaitiene
BACKGROUND: There is still insufficient knowledge on the potential effect of mild to moderate sleep-disordered breathing (SDB) that is widely prevalent, often asymptomatic, and largely undiagnosed in patients with stable coronary artery disease (CAD). SDB affects 34% of men and 17% of women aged between 30 and 70. The objective of this study was to evaluate the association between SDB and left ventricular (LV) hypertrophy as well as structural remodeling in stable CAD patients. METHODS: The study was based on a cross-sectional design...
September 18, 2017: BMC Cardiovascular Disorders
https://www.readbyqxmd.com/read/28921043/slow-wave-activity-and-executive-dysfunction-in-children-with-sleep-disordered-breathing
#4
Jessica A Christiansz, Chloe R Lappin, Aidan J Weichard, Gillian M Nixon, Margot J Davey, Rosemary S C Horne, Sarah N Biggs
PURPOSE: This study aimed to examine slow wave activity (SWA), a marker of homeostatic regulation, as a potential mechanism linking sleep disordered breathing (SDB) with executive dysfunction in children. METHODS: Executive function domains of working memory, spatial planning, information processing, and sustained attention were assessed using the Cambridge Neuropsychological Test Automated Battery (CANTAB) in children (N = 40; 5-12 years) referred for clinical diagnosis of SDB...
September 18, 2017: Sleep & Breathing, Schlaf & Atmung
https://www.readbyqxmd.com/read/28905231/sleep-disordered-breathing-and-the-risk-of-cognitive-decline-a-meta-analysis-of-19-940-participants
#5
REVIEW
Xiaoxia Zhu, Yanli Zhao
Sleep-disordered breathing (SDB) is related to the incidence of cognitive decline. However, results of cohort studies were inconsistent. We performed a meta-analysis of cohort studies to evaluate the sequential association between SDB and cognitive decline. Cohort studies were identified by the searching of PubMed and Embase databases. A random effect model was applied to combine the results. Nineteen thousand nine hundred forty participants from six cohort studies were included. Participants with SDB at baseline had significantly higher risk of cognitive decline, as indicated by a combined outcome of mild cognitive impairment (MCI) or dementia (RR = 1...
September 13, 2017: Sleep & Breathing, Schlaf & Atmung
https://www.readbyqxmd.com/read/28899542/predominant-obstructive-or-central-sleep-apnea-in-patients-with-atrial-fibrillation-influence-of-characterizing-apneas-versus-apneas-and-hypopneas
#6
Johanna Strotmann, Henrik Fox, Thomas Bitter, Florian Schindhelm, Klaus-Jürgen Gutleben, Dieter Horstkotte, Olaf Oldenburg
OBJECTIVE/BACKGROUND: Sleep-disordered breathing (SDB) is common in patients with atrial fibrillation (Afib). Although a high proportion of respiratory events are hypopneas, previous studies have only used apneas to differentiate obstructive (OSA) from central (CSA) sleep apnea. This study investigated the impact of using apneas and hypopneas versus apneas only to define the predominant type of SDB in Afib patients with preserved ejection fraction. PATIENTS/METHODS: This retrospective analysis was based on high-quality cardiorespiratory polygraphy (PG) recordings (07/2007-03/2016) that were re-analyzed using 2012 American Academy of Sleep Medicine criteria, with differentiation of apneas and hypopneas as obstructive or central...
September 2017: Sleep Medicine
https://www.readbyqxmd.com/read/28899523/validation-of-the-screening-tool-apnealink-%C3%A2-in-comparison-to%C3%A2-polysomnography-for-the-diagnosis-of-sleep-disordered-breathing%C3%A2-in-children-and-adolescents
#7
Florian Stehling, Judith Keull, Margarete Olivier, Jörg Große-Onnebrink, Uwe Mellies, Boris A Stuck
OBJECTIVE: While out-of-center testing was introduced as an alternative for the diagnosis of obstructive sleep apnea in adults, polysomnography (PSG) is still considered mandatory in the diagnosis of sleep-disordered breathing (SDB) in children. The purpose of this study was to validate the outpatient screening device ApneaLink(®) in comparison to PSG in children and adolescents for the diagnosis of SDB. METHODS: Sixty consecutive children and adolescents (10.4 ± 6...
September 2017: Sleep Medicine
https://www.readbyqxmd.com/read/28895457/polysomnography-in-pediatric-otolaryngology-if-not-obstructive-sleep-apnea-what-is-it
#8
Christine H Heubi, Jareen Meinzen-Derr, Sally R Shott, David F Smith, And Stacey L Ishman
Objective To determine common polysomnographic (PSG) diagnoses for children referred by otolaryngologists. Study Design Retrospective case series with chart review. Setting Single tertiary pediatric hospital (2010-2015). Subjects and Methods Review of the medical records of 1258 patients undergoing PSG by otolaryngology referral. Patients who underwent previous otolaryngologic surgery were excluded. Data distributions were evaluated using means with standard deviations for continuous variables and frequencies with percentages for categorical variables...
September 1, 2017: Otolaryngology—Head and Neck Surgery
https://www.readbyqxmd.com/read/28893762/sleep-disordered-breathing-in-acute-ischemic-stroke-a-mechanistic-link-to-peripheral-endothelial-dysfunction
#9
Nadja Scherbakov, Anja Sandek, Nicole Ebner, Miroslava Valentova, Alexander Heinrich Nave, Ewa A Jankowska, Jörg C Schefold, Stephan von Haehling, Stefan D Anker, Ingo Fietze, Jochen B Fiebach, Karl Georg Haeusler, Wolfram Doehner
BACKGROUND: Sleep-disordered breathing (SDB) after acute ischemic stroke is frequent and may be linked to stroke-induced autonomic imbalance. In the present study, the interaction between SDB and peripheral endothelial dysfunction (ED) was investigated in patients with acute ischemic stroke and at 1-year follow-up. METHODS AND RESULTS: SDB was assessed by transthoracic impedance records in 101 patients with acute ischemic stroke (mean age, 69 years; 61% men; median National Institutes of Health Stroke Scale, 4) while being on the stroke unit...
September 11, 2017: Journal of the American Heart Association
https://www.readbyqxmd.com/read/28890168/sleep-disturbances-increase-the-risk-of-dementia-a-systematic-review-and-meta-analysis
#10
REVIEW
Le Shi, Si-Jing Chen, Meng-Ying Ma, Yan-Ping Bao, Ying Han, Yu-Mei Wang, Jie Shi, Michael V Vitiello, Lin Lu
Sleep disturbances and dementia are two common and significant health problems in older adults. Investigations suggest that sleep disturbances might increase the risk of dementia. The aim of the present study was to systematically review and meta-analyze the predictive roles of overall sleep disturbances, their subtypes (e.g., insomnia, sleep disordered breathing [SDB]), and other sleep problems (e.g., excessive daytime sleepiness, sleep-related movement disorder, circadian rhythm sleep disorder, and nonspecific sleep problems) in incident all-cause dementia and Alzheimer's disease (AD) and vascular dementia subtypes...
July 6, 2017: Sleep Medicine Reviews
https://www.readbyqxmd.com/read/28888522/sleep-disordered-breathing-and-heart-failure-what-does-the-future-hold
#11
REVIEW
Martin R Cowie, Angela M Gallagher
Most patients with heart failure (HF) have sleep-disordered breathing (SDB), with central (rather than obstructive) sleep apnea becoming the predominant form in patients with more severe disease. Cyclical apnea and hypopneas are associated with sleep disturbance, hypoxemia, hemodynamic changes, and sympathetic activation. These patients have a worse prognosis than those without SDB. Mask-based therapies of positive airway pressure targeted at SDB can improve measures of sleep quality and can partially normalize the sleep and respiratory physiology...
August 30, 2017: JACC. Heart Failure
https://www.readbyqxmd.com/read/28874569/dorsolateral-prefrontal-cortex-gaba-deficit-in-older-adults-with-sleep-disordered-breathing
#12
Ana C Pereira, Xiangling Mao, Caroline S Jiang, Guoxin Kang, Sara Milrad, Bruce S McEwen, Ana C Krieger, Dikoma C Shungu
Sleep-disordered breathing (SDB) is a common disorder in aging that is associated with cognitive decline, including significant executive dysfunction, for which the neurobiological underpinnings remain poorly understood. Using proton magnetic resonance spectroscopy (1H MRS), this study assessed whether dysregulation of the homeostatic balance of the major inhibitory and excitatory amino acid neurotransmitter systems of γ-aminobutyric acid (GABA) and glutamate, respectively, play a role in SDB. Levels of GABA and those of the combined resonances of glutamate and glutamine (Glx), were measured by 1H MRS in the left dorsolateral prefrontal cortex (l-DLPFC) and bilateral hippocampal regions of 19 older adults (age ± SD: 66...
September 5, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28862662/snorap-a-device-for-the-correction-of-impaired-sleep-health-by-using-tactile-stimulation-for-individuals-with-mild-and-moderate-sleep-disordered-breathing
#13
Mete Yağanoğlu, Murat Kayabekir, Cemal Köse
Sleep physiology and sleep hygiene play significant roles in maintaining the daily lives of individuals given that sleep is an important physiological need to protect the functions of the human brain. Sleep disordered breathing (SDB) is an important disease that disturbs this need. Snoring and Obstructive Sleep Apnea Syndrome (OSAS) are clinical conditions that affect all body organs and systems that intermittently, repeatedly, with at least 10 s or more breathing stops that decrease throughout the night and disturb sleep integrity...
September 1, 2017: Sensors
https://www.readbyqxmd.com/read/28859720/sleep-overnight-monitoring-for-apnea-in-patients-hospitalized-with-heart-failure-soma-hf-study
#14
Sunil Sharma, Paul J Mather, Anindita Chowdhury, Suchita Gupta, Umer Mukhtar, Leslee Willes, David J Whellan, Atul Malhotra, Stuart F Quan
INTRODUCTION: Sleep-disordered breathing (SDB) is highly prevalent in hospitalized patients with congestive heart failure (CHF) and the condition is diagnosed and treated in only a minority of these patients. Portable monitoring (PM) is a screening option, but due to costs and the expertise required, many hospitals may find it impractical to implement. We sought to test the utility of an alternative approach for screening hospitalized CHF patients for SDB, high-resolution pulse oximetry (HRPO)...
August 29, 2017: Journal of Clinical Sleep Medicine: JCSM: Official Publication of the American Academy of Sleep Medicine
https://www.readbyqxmd.com/read/28846764/association-of-sleep-disordered-breathing-with-cognitive-function-and-risk-of-cognitive-impairment-a-systematic-review-meta-analysis
#15
Yue Leng, Claire T McEvoy, Isabel E Allen, Kristine Yaffe
Importance: Growing evidence suggests an association between sleep-disordered breathing (SDB) and cognitive decline in elderly persons. However, results from population-based studies have been conflicting, possibly owing to different methods to assess SDB or cognitive domains, making it difficult to draw conclusions on this association. Objective: To provide a quantitative synthesis of population-based studies on the relationship between SDB and risk of cognitive impairment...
August 28, 2017: JAMA Neurology
https://www.readbyqxmd.com/read/28834663/development-and-validation-of-a-novel-non-contact-monitor-of-nocturnal-respiration-for-identifying-sleep-disordered-breathing-in-patients-with-heart-failure
#16
Henry Oluwasefunmi Savage, Rami N Khushaba, Alberto Zaffaroni, Michael Colefax, Steven Farrugia, Klaus Schindhelm, Helmut Teschler, Gerhard Weinreich, Hartmut Grueger, Martina Neddermann, Conor Heneghan, Anita Simonds, Martin R Cowie
AIMS: At least 50% of patients with heart failure (HF) may have sleep-disordered breathing (SDB). Overnight in-hospital polysomnography (PSG) is considered the gold standard for diagnosis, but a lack of access to such testing contributes to under-diagnosis of SDB. Therefore, there is a need for simple and reliable validated methods to aid diagnosis in patients with HF. The aim of this study was to investigate the accuracy of a non-contact type IV screening device, SleepMinder(TM) (SM), compared with in-hospital PSG for detecting SDB in patients with HF...
September 2016: ESC Heart Failure
https://www.readbyqxmd.com/read/28834052/incidence-of-obstructive-sleep-apnea-in-elderly-edentulous-patients-and-the-possible-correlation-of-serum-serotonin-and-apnea-hypopnea-index
#17
Arvind Tripathi, Soumyojeet Bagchi, Juhi Singh, Suryakant Tripathi, Narendra Kumar Gupta, Varun Arora
PURPOSE: To estimate the incidence of obstructive sleep apnea (OSA) in elderly edentulous patients (aged 60-65 years) and investigate a correlation of serum serotonin levels with the apnea-hypopnea index (AHI), respiratory effort-related arousal (RERA), and respiratory disturbance index (RDI). MATERIALS AND METHODS: 381 elderly completely edentulous patients (307 male, 74 female) aged 60 to 65 years with a history of edentulism of 12 to 15 months, seeking oral rehabilitation at the prosthodontic clinic at Saraswati Dental College & Hospital, Lucknow, India, between January 2014 and January 2016 were enrolled for the present study...
August 21, 2017: Journal of Prosthodontics: Official Journal of the American College of Prosthodontists
https://www.readbyqxmd.com/read/28833232/persistent-respiratory-effort-after-adenotonsillectomy-in-children-with-sleep-disordered-breathing
#18
Jean-Benoît Martinot, N Nam Le-Dong, Stéphane Denison, Hervé Jean-Pierre Guénard, Jean-Christian Borel, Philip E Silkoff, Jean-Louis Pepin, David Gozal
OBJECTIVES: Adenotonsillectomy (AT) markedly improves but does not necessarily normalize polysomnographic findings in children with adenotonsillar hypertrophy and related sleep-disordered breathing (SDB). Adenotonsillectomy efficacy should be evaluated by follow-up polysomnography (PSG), but this method may underestimate persistent respiratory effort (RE). Mandibular movement (MMas) monitoring is an innovative measurement that readily identifies RE during upper airway obstruction. We hypothesized that MMas indices would decrease in parallel of PSG indices and that children with persistent RE more reliably could be identified with MMas...
August 22, 2017: Laryngoscope
https://www.readbyqxmd.com/read/28829519/looking-both-ways-before-crossing-the-street-assessing-the-benefits-and-risk-of-opioids-in-treating-patients-at-risk-of-sleep-disordered-breathing-for-pain-and-dyspnea
#19
Mellar P Davis, Bertrand Behm, Diwakar Balachandran
Opioids adversely influence respiration in five distinct ways. Opioids reduce the respiratory rate, tidal volume, amplitude, reflex responses to hypercapnia and hypoxia, and arousability related necessary for respiratory adaptive responses. Opioids cause impairment of upper pharyngeal dilator muscles leading to obstructive apnea. Opioids cause complex sleep disordered breathing (SDB) consisting of central sleep apnea and obstructive sleep apnea. Clinically opioids worsen pre-existing SDB. Recent studies have shown increased morbidity and mortality in patients receiving opioids for chronic noncancer pain and chronic obstructive pulmonary disease, which appear to be related to cardiovascular events, not overdose...
May 2017: Journal of Opioid Management
https://www.readbyqxmd.com/read/28827963/investigation-of-effect-of-1-8-cineole-on-antimicrobial-activity-of-chlorhexidine-gluconate
#20
Merih Şimşek, Reşat Duman
BACKGROUND: Chlorhexidine belongs to a group of medicines called antiseptic antibacterial agents. Chlorhexidine is commonly used for the care and clean off the skin, hands, and wounds. In recent years, medicinal and aromatic plants have been used for prevention of disease, maintaining health, and improving disease in traditional and modern medicine as a medicament. According to recent research, cineole is the isolated active agent of eucalyptus oil and possesses antimicrobial activity...
July 2017: Pharmacognosy Research
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