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https://www.readbyqxmd.com/read/28333111/solanesol-biosynthesis-in-plants
#1
REVIEW
Ning Yan, Yanhua Liu, Hongbo Zhang, Yongmei Du, Xinmin Liu, Zhongfeng Zhang
Solanesol is a non-cyclic terpene alcohol composed of nine isoprene units that mainly accumulates in solanaceous plants. Solanesol plays an important role in the interactions between plants and environmental factors such as pathogen infections and moderate-to-high temperatures. Additionally, it is a key intermediate for the pharmaceutical synthesis of ubiquinone-based drugs such as coenzyme Q10 and vitamin K2, and anti-cancer agent synergizers such as N-solanesyl-N,N'-bis(3,4-dimethoxybenzyl) ethylenediamine (SDB)...
March 23, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28329042/longitudinal-cardiovascular-outcomes-of-sleep-disordered-breathing-in-children-a-meta-analysis-and-systematic-review
#2
Zarmina Ehsan, Stacey L Ishman, Thomas R Kimball, Nanhua Zhang, Yuanshu Zou, Raouf S Amin
Objectives: The presence of sleep disordered breathing (SDB) is known to impact long-term cardiovascular morbidity in adults; however, the long-term effects in children are poorly understood. We aimed to systematically review and synthesize studies published to date on the long-term effects of SDB in children. Study Design: Meta-analysis and systematic review using PubMed, CINAHL,Embase and Scopus (all indexed years). Methods: We searched for English-language articles containing original human data from prospective studies, with ≥7 participants, in children ≤18 years of age...
January 28, 2017: Sleep
https://www.readbyqxmd.com/read/28321966/sleep-disordered-breathing-in-chronic-heart-failure-is-highly-variable-when-measured-remotely-using-a-novel-non-contact-biomotion-sensor
#3
Kenneth McDonald, Rory O'Hanlon, Henry Oluwasefunmi Savage, Rami N Khushaba, Michael Colefax, Steven Farrugia, Faizan Javed, Klaus Schindhelm, Ian Wilcox, Martin R Cowie
We used a remotely monitored non-contact biosensor (SleepMinder™) to measure breathing during sleep (SDB) in a prospective study of 91 patients with stable class II to IV heart failure (HF). The device algorithm measures a surrogate of the traditional apnoea/hypopnoea index (AHI) measured in polysomnographic sleep studies. Data was transmitted daily to a central monitoring centre and analysed in consecutive 2-week blocks. A total of 37 465 nights over 3-24 months was analysed. An AHI of >15/h was considered clinically significant...
March 21, 2017: European Journal of Heart Failure
https://www.readbyqxmd.com/read/28315149/can-myofunctional-therapy-increase-tongue-tone-and-reduce-symptoms-in-children-with-sleep-disordered-breathing
#4
Maria Pia Villa, Melania Evangelisti, Susy Martella, Mario Barreto, Marco Del Pozzo
PURPOSE: Data in the literature suggest that myofunctional therapy (MT) may be able to play a role in the treatment of children with sleep-disordered breathing (SDB). Our study investigated the effectiveness of MT in reducing respiratory symptoms in children with SDB by modifying tongue tone. METHODS: Polysomnographic recordings were performed at baseline to assess obstructive sleep apnea (OSA) severity in 54 children (mean age 7.1 ± 2.5 years, 29 male) with SDB...
March 18, 2017: Sleep & Breathing, Schlaf & Atmung
https://www.readbyqxmd.com/read/28306414/cross-sectional-comparison-of-sleep-disordered-breathing-in-native-peruvian-highlanders-and-lowlanders
#5
Luu V Pham, Christopher Meinzen, Rafael S Arias, Noah G Schwartz, Adi Rattner, Catherine H Miele, Philip L Smith, Hartmut Schneider, J Jaime Miranda, Robert H Gilman, Vsevolod Y Polotsky, William Checkley, Alan R Schwartz
Pham, Luu V., Christopher Meinzen, Rafael S. Arias, Noah G. Schwartz, Adi Rattner, Catherine H. Miele, Philip L. Smith, Hartmut Schneider, J. Jaime Miranda, Robert H. Gilman, Vsevolod Y. Polotsky, William Checkley, and Alan R. Schwartz. Cross-sectional comparison of sleep-disordered breathing in native Peruvian highlanders and lowlanders. High Alt Med Biol. 18:11-19, 2017. BACKGROUND: Altitude can accentuate sleep disordered breathing (SDB), which has been linked to cardiovascular and metabolic diseases...
March 2017: High Altitude Medicine & Biology
https://www.readbyqxmd.com/read/28300752/high-q-wafer-level-package-based-on-modified-tri-layer-anodic-bonding-and-high-performance-getter-and-its-evaluation-for-micro-resonant-pressure-sensor
#6
Liying Wang, Xiaohui Du, Lingyun Wang, Zhanhao Xu, Chenying Zhang, Dandan Gu
In order to achieve and maintain a high quality factor (high-Q) for the micro resonant pressure sensor, this paper presents a new wafer level package by adopting cross-layer anodic bonding technique of the glass/silicon/silica (GSS) stackable structure and integrated Ti getter. A double-layer structure similar to a silicon-on-insulator (SOI) wafer is formed after the resonant layer and the pressure-sensitive layer are bonded by silicon direct bonding (SDB). In order to form good bonding quality between the pressure-sensitive layer and the glass cap layer, the cross-layer anodic bonding technique is proposed for vacuum package by sputtering Aluminum (Al) on the combination wafer of the pressure-sensitive layer and the resonant layer to achieve electrical interconnection...
March 16, 2017: Sensors
https://www.readbyqxmd.com/read/28300569/obesity-as-an-effect-modifier-in-sleep-disordered-breathing-and-post-cardiac-surgery-atrial-fibrillation
#7
Roop Kaw, Samer El Zarif, Lu Wang, James Bena, Eugene Blackstone, Reena Mehra
INTRODUCTION: As the inter-relationships of objectively-ascertained sleep disordered breathing (SDB), post-cardiac surgery atrial fibrillation (PCSAF) and obesity remain unclear; we aimed to further investigate in a clinic-based cohort. METHODS: Patients with polysomnography (PSG) and cardiac surgery (coronary artery bypass surgery and/or valvular surgery) within 3 years, from January 2009 to January 2014 were identified excluding those with pre-existing AF. Logistic models were used to determine the association of SDB (apnea hypopnea index (AHI) per 5 unit increase) and secondary predictors [central sleep apnea (CSA) (central apnea index>5) and oxygen desaturation index (ODI)] with PCSAF...
March 11, 2017: Chest
https://www.readbyqxmd.com/read/28291799/high-risk-of-developing-subsequent-epilepsy-in-patients-with-sleep-disordered-breathing
#8
Tomor Harnod, Yu-Chiao Wang, Cheng-Li Lin, Chun-Hung Tseng
PURPOSE: Sleep-disordered breathing (SDB) is often associated with other medical disorders. Whether SDB interacts with other factors for developing subsequent epilepsy remains unclear. METHODS: This population-based cohort study was conducted using the National Health Insurance Research Database of Taiwan. Patients aged >20 years and diagnosed with SDB between 2000 and 2010 comprised the SDB cohort (n = 138,507), and their data were compared with those of the comparison cohort (n = 138,507)...
2017: PloS One
https://www.readbyqxmd.com/read/28289832/indirect-costs-related-to-caregivers-absence-from-work-after-paediatric-tonsil-surgery
#9
Gunnhildur Gudnadottir, G Ragnarson Tennvall, J Stalfors, J Hellgren
Tonsillotomy has gradually replaced tonsillectomy as the surgical method of choice in children with upper airway obstruction during sleep, because of less postoperative pain and a shorter recovery time. The aim of this study was to examine the costs related to caregivers' absenteeism from work after tonsillectomy (TE) and tonsillotomy (TT). All tonsillectomies and tonsillotomies in Sweden due to upper airway obstruction during 1 year, reported to the National Tonsil Surgery Register in children aged 1-11 were included, n = 4534...
March 14, 2017: European Archives of Oto-rhino-laryngology
https://www.readbyqxmd.com/read/28281834/association-of-sleep-disordered-breathing-with-diabetes-associated-kidney-disease
#10
Stefan Stadler, Tanja Zimmermann, Franziska Franke, Myriam Rheinberger, Iris M Heid, Carsten A Böger, Michael Arzt
INTRODUCTION: Diabetes-associated kidney disease is characterized by impairment of renal function and albuminuria. The aim of the present study was to assess whether sleep-disordered breathing is associated with decreased estimated glomerular filtration rate or increased urine-albumin-to-creatinine-ratio independently from known modulators of diabetes-associated kidney disease. MATERIAL AND METHODS: Estimated glomerular filtration rate and urine-albumin-to-creatinine-ratio were determined in the baseline survey of the DIACORE-SDB substudy, a prospectively planned study of Diabetes mellitus 2 patients...
March 10, 2017: Annals of Medicine
https://www.readbyqxmd.com/read/28268691/design-and-preliminary-evaluation-of-a-wearable-device-for-mass-screening-of-sleep-apnea
#11
Rohan S Puri, Athanasios G Athanassiadis, Niharika Gill, Sai Sri Sathya, Geetanjali Rathod, Akshat Wahi, Guy Satat, Maulik Majmudar, Pratik Shah
Between 7-18 million Americans suffer from sleep disordered breathing (SDB), including those who suffer from obstructive sleep apnea (OSA). Despite this high prevalence and burden of OSA, existing diagnostic techniques remain impractical for widespread screening. In this study, we introduce a new model for OSA screening and describe an at-home wearable sleep mask (named ARAM) that can robustly track the wearers' sleep patterns. This monitoring is achieved using select sensors that enable screening and monitoring in a form-factor that can be easily self-instrumented...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28266568/elucidation-of-terpenoid-metabolism-in-scoparia-dulcis-by-rna-seq-analysis
#12
Yoshimi Yamamura, Fumiya Kurosaki, Jung-Bum Lee
Scoparia dulcis biosynthesize bioactive diterpenes, such as scopadulcic acid B (SDB), which are known for their unique molecular skeleton. Although the biosynthesis of bioactive diterpenes is catalyzed by a sequence of class II and class I diterpene synthases (diTPSs), the mechanisms underlying this process are yet to be fully identified. To elucidate these biosynthetic machinery, we performed a high-throughput RNA-seq analysis, and de novo assembly of clean reads revealed 46,332 unique transcripts and 40,503 two unigenes...
March 7, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28245272/impact-of-self-reported-symptoms-of-allergic-rhinitis-and-asthma-on-sleep-disordered-breathing-and-sleep-disturbances-in-the-elderly-with-polysomnography-study
#13
Sae-Hoon Kim, Ha-Kyeong Won, Sung-Do Moon, Byung-Keun Kim, Yoon-Seok Chang, Ki-Woong Kim, In-Young Yoon
BACKGROUND: Sleep disordered breathing (SDB) and sleep disturbances have been reported to be associated with allergic rhinitis and asthma. However, population-based studies of this issue in the elderly are rare. OBJECTIVE: To investigate the impact of self-reported rhinitis and asthma on sleep apnea and sleep quality using polysomnography in an elderly Korean population. METHODS: A total of 348 elderly subjects who underwent one-night polysomnography study among a randomly selected sample were enrolled...
2017: PloS One
https://www.readbyqxmd.com/read/28226878/design-and-preliminary-evaluation-of-a-wearable-device-for-mass-screening-of-sleep-apnea
#14
Rohan S Puri, Athanasios G Athanassiadis, Niharika Gill, Sai Sri Sathya, Geetanjali Rathod, Akshat Wahi, Guy Satat, Maulik Majmudar, Pratik Shah, Rohan S Puri, Athanasios G Athanassiadis, Niharika Gill, Sai Sri Sathya, Geetanjali Rathod, Akshat Wahi, Guy Satat, Maulik Majmudar, Pratik Shah, Athanasios G Athanassiadis, Maulik Majmudar, Geetanjali Rathod, Sai Sri Sathya, Akshat Wahi, Niharika Gill, Pratik Shah, Rohan S Puri, Guy Satat
Between 7-18 million Americans suffer from sleep disordered breathing (SDB), including those who suffer from obstructive sleep apnea (OSA). Despite this high prevalence and burden of OSA, existing diagnostic techniques remain impractical for widespread screening. In this study, we introduce a new model for OSA screening and describe an at-home wearable sleep mask (named ARAM) that can robustly track the wearers' sleep patterns. This monitoring is achieved using select sensors that enable screening and monitoring in a form-factor that can be easily self-instrumented...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28225162/mandibular-position-and-movements-suitability-for-diagnosis-of-sleep-apnoea
#15
Jean-Benoit Martinot, Jean-Christian Borel, Valérie Cuthbert, Hervé Jean-Pierre Guénard, Stéphane Denison, Philip E Silkoff, David Gozal, Jean-Louis Pepin
BACKGROUND AND OBJECTIVE: Mandibular movements (MMs) and position during sleep reflect respiratory efforts related to increases in upper airway resistance and micro-arousals. The study objective was to assess whether MM identifies sleep-disordered breathing (SDB) in patients with moderate to high pre-test probability. METHODS: This was a prospective study of 87 consecutive patients referred for an in-laboratory sleep test. Magnetometer-derived MM signals were incorporated into standard polysomnography (PSG)...
April 2017: Respirology: Official Journal of the Asian Pacific Society of Respirology
https://www.readbyqxmd.com/read/28224726/a%C3%A4-rway-and-sleep-d%C3%A4-sorders-%C3%A4-n-pat%C3%A4-ents-w%C3%A4-th-acromegaly
#16
Onur Turan, Barış Akıncı, Ahmet Omer Ikız, Oya Itıl, Ibrahim Oztura, Emel Ada, Bahri Akdenız, Serkan Yener, Murat Kaya, Arzu Gedık, Abdurrahman Comlekcı
INTRODUCTION-OBJECTIVE: Acromegaly is a multisystemic disorder caused by excessive secretion of growth hormone (GH). Sleep-disordered breathing (SDB) such as sleep apnea syndrome (SAS) may occur in acromegaly. The aim of study was to assess the presence of sleep disorders and evaluate the systemic complications on respiratory, cardiovascular and upper airway systems in acromegalic patients. METHODS: The study group consisted of 30 acromegaly outpatients. GH and insulin-like growth factor 1 (IGF-1) measurements were obtained; body pletysmography, arterial blood gas analysis,tissue-doppler imaging,echocardiography,polysomnography,otorhinolaryngologic examination and head-neck computed tomography were performed...
February 22, 2017: Clinical Respiratory Journal
https://www.readbyqxmd.com/read/28224648/impacts-of-disease-severity-on-postoperative-complications-in-children-with-sleep-disordered-breathing
#17
Kun-Tai Kang, I-Sheng Chang, Chia-Chen Tseng, Wen-Chin Weng, Tzu-Yu Hsiao, Pei-Lin Lee, Wei-Chung Hsu
OBJECTIVES/HYPOTHESIS: To investigate the effects of diseases severity on postoperative complications following adenotonsillectomy (T&A) in children with sleep-disordered breathing (SDB). STUDY DESIGN: Retrospective study. METHODS: Children aged <18 years were enrolled and underwent T&A for treating SDB. Polysomnography was used to classify the disease severity: primary snoring (apnea-hypopnea index [AHI] <1), mild (AHI = 1-5), moderate (AHI = 5-10), and severe obstructive sleep apnea [OSA] (AHI ≥10)...
February 22, 2017: Laryngoscope
https://www.readbyqxmd.com/read/28216558/application-of-passive-sampling-to-characterise-the-fish-exometabolome
#18
Mark R Viant, Jessica Elphinstone Davis, Cathleen Duffy, Jasper Engel, Craig Stenton, Marion Sebire, Ioanna Katsiadaki
The endogenous metabolites excreted by organisms into their surrounding environment, termed the exometabolome, are important for many processes including chemical communication. In fish biology, such metabolites are also known to be informative markers of physiological status. While metabolomics is increasingly used to investigate the endogenous biochemistry of organisms, no non-targeted studies of the metabolic complexity of fish exometabolomes have been reported to date. In environmental chemistry, Chemcatcher(®) (Portsmouth, UK) passive samplers have been developed to sample for micro-pollutants in water...
February 14, 2017: Metabolites
https://www.readbyqxmd.com/read/28215238/sleep-disordered-breathing-in-children-with-cerebral-palsy
#19
Engin Koyuncu, Mustafa H Türkkani, Fatma G Sarikaya, Neşe Özgirgin
OBJECTIVES: The purpose of this study was to investigate the frequency of Sleep Disordered Breathing (SDB) in children with Cerebral Palsy (CP), and determine whether a relationship between SDB and age, gender, weight status, type of CP, motor function level, and spasticity can be established. METHODS: The study included 94 children with CP and 94 healthy children with normal development, between the ages two and 18. SDB was assessed using the Sleep-Related Breathing Disorder (SRBD) scale of the Pediatric Sleep Questionnaire (PSQ)...
February 2017: Sleep Medicine
https://www.readbyqxmd.com/read/28213507/effect-of-sleep-disordered-breathing-on-appropriate-implantable-cardioverter-defibrillator-therapy-in-patients-with-heart-failure-a-systematic-review-and-meta-analysis
#20
Younghoon Kwon, Ryan J Koene, Osung Kwon, Jessica V Kealhofer, Selcuk Adabag, Sue Duval
BACKGROUND: Patients with heart failure and reduced ejection fraction are at increased risk of malignant ventricular arrhythmias. Implantable cardioverter-defibrillator (ICD) is recommended to prevent sudden cardiac death in some of these patients. Sleep-disordered breathing (SDB) is highly prevalent in this population and may impact arrhythmogenicity. We performed a systematic review and meta-analysis of prospective studies that assessed the impact of SDB on ICD therapy. METHODS AND RESULTS: Relevant prospective studies were identified in the Ovid MEDLINE, EMBASE, and Google Scholar databases...
February 2017: Circulation. Arrhythmia and Electrophysiology
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