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https://www.readbyqxmd.com/read/29459223/ambulatory-practice-of-dermatologists-in-taiwan-a-nationwide-survey
#1
Ying-Xiu Dai, Tzeng-Ji Chen, Yun-Ting Chang
BACKGROUND: Skin diseases are among the most common public health problems and cause a significant burden. For policymakers and clinicians, comprehensive and detailed information is necessary to better allocate resources needed to care for skin diseases. This study was conducted to characterize the ambulatory practice of dermatologists in Taiwan. METHODS: The study data were drawn from the datasets of Taiwan's National Health Insurance Research Database for 2013, with 623,614 records of ambulatory care visits representing 1/500 of all the claims in Taiwan for 2013...
February 16, 2018: Journal of the Chinese Medical Association: JCMA
https://www.readbyqxmd.com/read/29444375/the-efficacy-and-safety-of-non-pharmacological-therapies-for-the-treatment-of-acne-vulgaris-a-systematic-review-and-best-evidence-synthesis
#2
F M C de Vries, A M Meulendijks, R J Driessen, A A van Dooren, E P M Tjin, P C M van de Kerkhof
BACKGROUND: Acne vulgaris is a multifaceted skin disorder, affecting more than 85% of young individuals worldwide. Pharmacological therapy is not always desirable because of the development of antibiotic resistance or the potential risk of adverse effects. Non-pharmacological therapies can be viable alternatives for conventional therapies. However, sufficient evidence based support in the efficacy and safety of non-pharmacological therapies is lacking. OBJECTIVE: To assess the efficacy and safety of several non-pharmacological therapies in the treatment of acne vulgaris...
February 14, 2018: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/29409921/a-rationally-designed-multi-functional-antibiotic-for-the-treatment-of-drug-resistant-acne
#3
Sumana Ghosh, Mau Sinha, Anamika Bhattacharyya, Suresh Sadhasivam, Jayasundarnaidu Megha, Sreedhar Reddy, Swamini Saini, Himanshi Singh, Deepak Kumar, Simar Preet Kaur, Mallika Mishra, Dandamudi Usharani, Shamik Ghosh, Shiladitya Sengupta
Acne is a multifactorial skin disease, underpinned by colonization of Propionibacterium acnes and inflammation. The emergence of resistant Propionibacterium acnes strains has affected the current acne treatment algorithm. This setback served as an impetus for rationally designing a library of next-generation antibiotics that exhibit a bactericidal effect on resistant Propionibacterium acnes as well as exert an immunomodulatory function to reduce inflammation. In silico screening revealed that one of the molecules, VCD-004, exhibits improved mode of binding to bacterial DNA gyrase...
January 30, 2018: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/29400580/picosecond-alexandrite-laser-is-superior-to-q-switched-nd-yag-laser-in-treatment-of-minocycline-induced-hyperpigmentation-a-case-study-and-review-of-the-literature
#4
Tom Barrett, Sally de Zwaan
Minocycline is a commonly prescribed tetracycline antibiotic used for the treatment of a number of dermatological conditions including acne and rosacea. Long-term adverse effects of minocycline include cutaneous hyperpigmentation. Various treatment options have been suggested for the treatment of minocycline pigmentation. We report a case of a patient on long-term low-dose minocycline for the treatment of rosacea with type III minocycline hyperpigmentation. A comparison was made between Q-Switch Nd:YAG and picosecond laser over a nine 9-period with treatments spaced 1 month apart, with a clearance in the patient pigmentation after four treatments with picosecond laser...
February 5, 2018: Journal of Cosmetic and Laser Therapy: Official Publication of the European Society for Laser Dermatology
https://www.readbyqxmd.com/read/29373772/-periodontal-microbiota-and-microorganisms-isolated-from-heart-valves-in-patients-undergoing-valve-replacement-surgery-in-a-clinic-in-cali-colombia
#5
Sandra Moreno, Beatriz Parra, Javier E Botero, Freddy Moreno, Daniel Vásquez, Hugo Fernández, Sandra Alba, Sara Gallego, Gilberto Castillo, Adolfo Contreras
INTRODUCTION: Periodontitis is an infectious disease that affects the support tissue of the teeth and it is associated with different systemic diseases, including cardiovascular disease. Microbiological studies facilitate the detection of microorganisms from subgingival and cardiovascular samples. OBJECTIVE: To describe the cultivable periodontal microbiota and the presence of microorganisms in heart valves from patients undergoing valve replacement surgery in a clinic in Cali...
December 1, 2017: Biomédica: Revista del Instituto Nacional de Salud
https://www.readbyqxmd.com/read/29361412/prevalence-of-propionibacterium-acnes-in-the-glenohumeral-compared-with-the-subacromial-space-in-primary-shoulder-arthroscopies
#6
Thilo Patzer, Sabine Petersdorf, Ruediger Krauspe, Pablo Emilio Verde, Birgit Henrich, Martin Hufeland
HYPOTHESIS: We hypothesized that the prevalence of Propionibacterium acnes in patients undergoing primary shoulder arthroscopy is equal in the glenohumeral space compared with the subacromial space. METHODS: Patients aged 18 years or older with shoulder arthroscopies were included. The exclusion criteria were prior shoulder operations, complete rotator cuff tears, systemic inflammatory diseases, tumors, shoulder injections within 6 months of surgery, and antibiotic therapy within 14 days preoperatively...
January 18, 2018: Journal of Shoulder and Elbow Surgery
https://www.readbyqxmd.com/read/29325951/shunt-nephritis-an-increasingly-unfamiliar-diagnosis
#7
Tessa A Harland, Ken R Winston, Anna J Jovanovich, Richard J Johnson
BACKGROUND: Shunt nephritis is a rare, reversible immune-complex mediated complication of CSF shunt infection that can progress to end-stage renal disease and even death if diagnosis is delayed. CASE DESCRIPTION: The present case report details the manifestation and clinical course of shunt nephritis in a 50-year old patient who presented with symptoms of nephrotic syndrome 30 years after ventriculo-jugular shunt placement. Diagnosis was delayed due to initial negative CSF and blood cultures but later a CSF culture was positive for Propionibacterium acnes...
January 8, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29280824/a-case-of-relapsing-polychondritis-mimicking-hemophagocytic-lymphohistiocytosis-after-propionibacterium-acnes-infection
#8
William E Monaco, Carey J Field, Thomas H Taylor
We describe a 69-year-old man who presented with a right sternocleidomastoid intramuscular abscess that grew Propionibacterium acnes. Despite initial improvement with antibiotics, he subsequently developed signs and symptoms fulfilling diagnostic criteria for hemophagocytic lymphohistiocytosis (HLH)-fevers, cytopenias, hyperferritinemia, splenomegaly, and low natural killer cell activity. The patient improved spontaneously but at outpatient follow-up complained of erythema over the bridge of his nose as well as bilateral ear redness sparing the earlobes at which point relapsing polychondritis (RP) was diagnosed...
December 27, 2017: Journal of Clinical Rheumatology: Practical Reports on Rheumatic & Musculoskeletal Diseases
https://www.readbyqxmd.com/read/29234829/-drug-therapy-of-acne-inversa
#9
REVIEW
S Schneider-Burrus, E Arpa, C Kors, T Stavermann, R Sabat, G Kokolakis
Acne inversa is a chronic inflammatory destructive skin disease that affects about 1% of the population. The therapy should be personalized and consists of surgical and conservative procedures. Antibiotics are administered either topically or systemically. Combination therapy with clindamycin and rifampicin for 10-12 weeks can be very effective. Furthermore, TNF-α inhibitors show adequate efficacy and can be recommended. Adalimumab is the only approved drug product for systemic treatment of acne inversa...
December 12, 2017: Der Hautarzt; Zeitschrift Für Dermatologie, Venerologie, und Verwandte Gebiete
https://www.readbyqxmd.com/read/29215319/examining-the-potential-preventative-effects-of-minocycline-prescribed-for-acne-on-the-incidence-of-severe-mental-illnesses-a-historical-cohort-study
#10
Maria Herrero-Zazo, Ruth Brauer, Fiona Gaughran, Louise M Howard, David Taylor, David J Barlow
BACKGROUND: Animal studies suggest that the antibiotic and microglial activation inhibitor, minocycline, is likely to have a protective effect against the emergence of psychosis but evidence from human studies is lacking. The aim of this study is to examine the effects of exposure to minocycline during adolescence on the later incidence of severe mental illness (SMI). METHODS: A historical cohort study using electronic primary care data was conducted to assess the association between exposure to minocycline during adolescence and incidence of SMI...
December 1, 2017: Journal of Psychopharmacology
https://www.readbyqxmd.com/read/29203432/propionibacterium-acnes-prosthetic-joint-infection-diagnosis-and-treatment
#11
REVIEW
P Boisrenoult
Propionibacterium acnes is a commensal skin bacterium, regularly implicated in prosthetic joint infection, particularly of the shoulder. Diagnosis has been improved by progress in bacteriological techniques: longer culture time, liquid medium culture, MALDI-TOF mass spectrography, and universal 16S rRNA PCR, associated by some authors to sonication of ablated implants. P. acnes pathogenicity involves many virulence factors, notably including biofilm formation. P. acnes may lead to infection that is clinically evident or, frequently, relatively asymptomatic...
December 1, 2017: Orthopaedics & Traumatology, Surgery & Research: OTSR
https://www.readbyqxmd.com/read/29193602/the-role-of-zinc-in-the-treatment-of-acne-a-review-of-the-literature
#12
REVIEW
Jessica Cervantes, Ariel E Eber, Marina Perper, Vanessa M Nascimento, Keyvan Nouri, Jonette E Keri
Acne vulgaris is a chronic disease of the pilosebaceous units presenting as inflammatory or noninflammatory lesions in individuals of all ages. The current standard of treatment includes topical formulations in the forms of washes, gels, lotions, and creams such as antibiotics, antibacterial agents, retinoids, and comedolytics. Additionally, systemic treatments are available for more severe or resistant forms of acne. Nevertheless, these treatments have shown to induce a wide array of adverse effects, including dryness, peeling, erythema, and even fetal defects and embolic events...
November 28, 2017: Dermatologic Therapy
https://www.readbyqxmd.com/read/29188173/influence-of-sonication-on-bacterial-regrowth-from-antibiotic-loaded-pmma-scaffolds-an-in-vitro-study
#13
Martin Clauss, Esther Laschkolnig, Susanne Graf, Klaus-Dieter Kühn
Periprosthetic joint infection (PJI) is one of the most challenging complications after joint replacement. However, when treated correctly, chances of recovery are good. The most important step in correct diagnosis and management of PJI is the detection of the causative germ. In the last years, the use of sonication in the diagnostic process has become more important. However, this diagnostic methodology has been controversially discussed when used in combination with antibiotic loaded bone cement (PMMA), which is frequently used in joint replacement surgeries...
2017: Journal of Bone and Joint Infection
https://www.readbyqxmd.com/read/29182717/doxycycline-in-the-management-of-sexually-transmitted-infections
#14
Hélène Peyriere, Alain Makinson, Hélène Marchandin, Jacques Reynes
Doxycycline is a second-generation tetracycline, available worldwide for half a century. It is an inexpensive broad-spectrum antimicrobial agent largely used in the management of several bacterial infections, particularly involving intracellular pathogens, as well as in the treatment of acne or for the prophylaxis of malaria. Physicochemical characteristics of doxycycline (liposolubility) allow a high diffusion in the tissues and organs. It has high bioavailability and a long elimination half-life allowing oral administration of one or two daily doses...
November 22, 2017: Journal of Antimicrobial Chemotherapy
https://www.readbyqxmd.com/read/29178982/microbiology-and-associated-risk-factors-in-alloplastic-total-joint-infections-a-20-year-retrospective-study
#15
Rhae Riegel, Kevin Sweeney, Gino Inverso, Peter Quinn, Eric J Granquist
PURPOSE: Prosthetic joint infection (PJI) is a rare complication of temporomandibular joint replacement (TJR). This study evaluated TJR PJIs at the authors' institution over a 20-year period, including micro-organisms cultured, antibiotic resistance patterns, and intraoperative protocols of TJR. PATIENTS AND METHODS: Patients were identified using Current Procedural Terminology and International Classification of Diseases, Ninth Revision codes and surgical logs from January 1995 through 2015...
November 8, 2017: Journal of Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/29167293/perioperative-antibiotic-prophylaxis-has-no-effect-on-time-to-positivity-and-proportion-of-positive-samples-a-cohort-study-of-64-cutibacterium-acnes-bone-and-joint-infections
#16
Alexia Anagnostopoulos, Daniel A Bossard, Bruno Ledergerber, Patrick O Zingg, Annelies S Zinkernagel, Christian Gerber, Yvonne Achermann
If a bone or joint infection is suspected, perioperative antibiotic prophylaxis is frequently withheld until the intraoperative microbiological sampling has been performed. This practice builds upon the hypothesis that perioperative antibiotics could render culture results negative and thus impede tailored antibiotic treatment of infections. We aimed to assess the influence of antibiotic prophylaxis within 30 to 60 minutes before surgery on time to positivity of microbiological samples and proportion of positive samples in Cutibacterium acnes bone and joint infections...
November 22, 2017: Journal of Clinical Microbiology
https://www.readbyqxmd.com/read/29141062/management-of-severe-acne-vulgaris-with-topical-therapy
#17
Linda Stein Gold, Hilary E Baldwin, Tina Lin
<p>Acne vulgaris (acne) is the most common skin disease we see in dermatology practice. Although rare in childhood, severe acne can affect up to 12% of the adolescent population. A chronic disease, it requires both aggressive management and effective maintenance strategies. Oral antibiotics, in combination with topical agents are recommended for treatment, with topical agents being continued as maintenance therapy to minimize resistance and recurrence. However, concerns with systemic side effects have recently resulted in a greater focus on the potential of fixed combination topical therapies to treat severe acne...
November 1, 2017: Journal of Drugs in Dermatology: JDD
https://www.readbyqxmd.com/read/29138059/pityrosporum-folliculitis-a-retrospective-review-of-110-cases
#18
Brea Prindaville, Leah Belazarian, Nikki A Levin, Karen Wiss
BACKGROUND: Pityrosporum folliculitis is an under-recognized eruption of the face and upper trunk that may be confused with, or occur simultaneously with, acne vulgaris. OBJECTIVE: We sought to characterize risk factors for Pityrosporum folliculitis, its clinical presentation, and response to treatment. METHODS: A retrospective chart review was performed on all patients aged 0 to 21 years seen from 2010-2015 with Pityrosporum folliculitis confirmed by potassium hydroxide (KOH) preparation...
November 11, 2017: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/29131127/pleiotropic-effects-of-white-willow-bark-and-1-2-decanediol-on-human-adult-keratinocytes
#19
Eleonora Bassino, Franco Gasparri, Luca Munaron
BACKGROUND: Acne vulgaris is a common skin defect, usually occurring during adolescence, but often it can persist in adults leaving permanent face scarring. Acne is usually treated with topical drugs, oral antibiotics, retinoids, and hormonal therapies, but medicinal plants are increasingly employed. OBJECTIVE: To investigate the protective role of white willow bark (WWB) and 1,2-decanediol (DD) on the damage caused by lipopolysaccharides (LPS) on human adult keratinocytes (HaCaT)...
November 8, 2017: Skin Pharmacology and Physiology
https://www.readbyqxmd.com/read/29125405/cutibacterium-formerly-propionibacterium-acnes-infections-associated-with-implantable-devices
#20
Amal A Gharamti, Zeina A Kanafani
Cutibacterium acnes (C. acnes), a Gram-positive biofilm-forming rod implicated in acne vulgaris, is increasingly recognized for its role in implant-associated infections. The diagnosis of C. acnes implant-associated infections remains challenging. The optimal treatment is a combination of both surgical intervention and antibiotic therapy. Areas covered: In this review, we discuss the different types of implant-associated infections caused by C. acnes. We also highlight the clinical manifestations pertaining to the various sites of infection, and identify several risk factors previously reported in the literature...
December 2017: Expert Review of Anti-infective Therapy
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