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https://www.readbyqxmd.com/read/29033263/-persistent-extra-axial-post-surgical-collections-and-propionibacterium-acnes-infection-presentation-of-two-cases-and-literature-review
#1
Pedro González, José Thenier, Raúl Galárraga, Adolfo de la Lama, Eva Azevedo, Cesáreo Conde
OBJECTIVES: It is common to observe the persistence of extra-axial collections after craniotomies. Most of these disappear in weeks or months but some remain. The onset of focal symptoms or the growth of these persistent collections months or years after surgery may indicate the presence of a chronic and latent infection by germs of low virulence such as Propionibacterium acnes (P. acnes). METHODS: We present two clinical cases with persistent extra-axial collections, which required surgery years after diagnosis, in which P...
October 13, 2017: Neurocirugía
https://www.readbyqxmd.com/read/29023067/studies-on-staphylococcus-aureus-isolated-from-pimples
#2
Ajayi Adesola Adetutu, Bibi Oritsewehinmi, Oniha Margaret Ikhiwili, Atolagbe Oluwabunmi Moradeke, Anosike Selina Odochi, Onibokun Elizabeth Adeola
BACKGROUND AND OBJECTIVE: Pimples (acne) are small skin lesions or inflammations of the skin. The most common factor causing acne is the hormonal changes that occur during adolescent and teenage years. Antibiotics are becoming less effective in the treatment of pimples due to increasing concerns of antibiotic resistance. This study was therefore carried out to characterize the isolates from the pimples of Covenant University Students and to determine their antibiotics sensitivity pattern...
2017: Pakistan Journal of Biological Sciences: PJBS
https://www.readbyqxmd.com/read/29022059/targeted-intervention-of-acute-postoperative-infection-after-rotator-cuff-repair-results-in-good-functional-outcomes
#3
Kjersti Kaul Jenssen, Kirsten Lundgreen, Jan Erik Madsen, Sigbjørn Dimmen
PURPOSE: The primary goal of this retrospective review of a prospective database was to document the functional results after acute postoperative deep infection following rotator cuff repair in a single orthopaedic unit over a period of 5 years. Secondary goals were to document the effect of infection on healing of the cuff repair and to describe its incidence, diagnostic challenges, pathogens and management. METHODS: Patients undergoing arthroscopic rotator cuff repair were prospectively registered from 2010 to 2014...
October 11, 2017: Knee Surgery, Sports Traumatology, Arthroscopy: Official Journal of the ESSKA
https://www.readbyqxmd.com/read/29019804/quantification-of-propionic-acid-in-the-bovine-spinal-disk-after-infection-of-the-tissue-with-p-acnes-bacteria
#4
Sergey Magnitsky, Stefan Dudli, Xinyan Tang, Jaskanwaljeet Kaur, Joycelyn Diaz, Steve Miller, Jeffrey C Lotz
STUDY DESIGN: Research OBJECTIVE.: The goal of this study was to investigate whether P. acnes infection of the intervertebral disc can be detected noninvasively by NMR spectroscopy. SUMMARY OF BACKGROUND DATA: Microbiological studies of surgical samples suggest that a significant subpopulation of back pain patients may have occult disc infection with P. acnes bacteria. This hypothesis is further supported by a double-blind clinical trial showing that back pain patients with Modic type 1 changes may respond to antibiotic treatment...
October 10, 2017: Spine
https://www.readbyqxmd.com/read/28993066/clinical-and-microbiological-profile-of-infectious-keratitis-in-an-area-of-madrid-spain
#5
Soraya Mediero, Ana Boto de Los Bueis, Karina Spiess, Mariana Díaz-Almirón, Almudena Del Hierro Zarzuelo, Isabel Villalaín Rodes, Adela García Perea
INTRODUCTION: To study antibiotic susceptibility in bacterial keratitis (BK), its profile over 10 years and its influence on ophthalmological practice. METHODS: Retrospective review of BK with positive corneal scraping over a 10-year period. Risk factors for keratitis, visual acuity (VA), empirical topical treatment, corneal infection characteristics and outcomes were analyzed for BK due to Staphylococcus aureus, Staphylococcus epidermidis, Streptococcus pneumoniae, Pseudomonas aeruginosa and Propionibacterium acnes...
October 6, 2017: Enfermedades Infecciosas y Microbiología Clínica
https://www.readbyqxmd.com/read/28991607/long-term-effects-of-cataract-surgery-with%C3%A2-topical-levofloxacin-on-ocular-bacterial-flora
#6
Takashi Ono, Ryohei Nejima, Takuya Iwasaki, Yosai Mori, Yukari Noguchi, Akiko Yagi, Hideaki Hanaki, Kazunori Miyata
PURPOSE: To clarify the long-term effect of topical antibiotics on the ocular bacterial flora after cataract surgery. SETTING: Miyata Eye Hospital, Miyazaki, Japan. DESIGN: Prospective case series. METHODS: Patients who had cataract surgery between November 2014 and January 2015 were included. Levofloxacin 1.5% was administered 4 times a day by topical instillation from 3 days before surgery to 1 month postoperatively...
September 2017: Journal of Cataract and Refractive Surgery
https://www.readbyqxmd.com/read/28989281/efficacy-and-tolerability-of-liposomal-polyvinylpyrrolidone-iodine-hydrogel-for-the-localized-treatment-of-chronic-infective-inflammatory-dermatoses-an-uncontrolled-pilot-study
#7
Matthias Augustin, Lisa Goepel, Arnd Jacobi, Bjoern Bosse, Stefan Mueller, Michael Hopp
Infection is common in many chronic, inflammatory skin conditions but is often difficult to treat, in part due to growing bacterial resistance to antibiotics. Liposomal polyvinyl-pyrrolidone (PVP)-iodine hydrogel has a unique mode of action, combining the antiseptic and anti-inflammatory actions of PVP-iodine with the drug delivery and moisturizing properties of liposomes. We investigated the utility of liposomal PVP-iodine to treat infective dermatoses. In this prospective, single-arm (uncontrolled), open-label Phase II pilot study, patients with acne vulgaris (n=30), atopic dermatitis (n=20), impetigo contagiosa (n=10), and rosacea (n=10) received PVP-iodine (3%) hydrogel for ≤4 weeks...
2017: Clinical, Cosmetic and Investigational Dermatology
https://www.readbyqxmd.com/read/28985974/what-is-the-role-of-the-bacterium-propionibacterium-acnes-in-type-1-modic-changes-a-review-of-the-literature
#8
REVIEW
Mark Georgy, Mark Stern, Kieran Murphy
This review presents a summary of the pathology and epidemiology of Modic changes and the possible role of Propionibacterium acnes. This information is followed by a synthesis of the most recent clinical research involved in culturing the discs of patients with degenerative disc disease for the presence of bacteria. We also discuss a randomized controlled trial that investigates the effects of antibiotics on patients with chronic low back pain and type 1 Modic changes. We conclude with a brief discussion of the difficulties involved in this research and the significance of the findings...
October 3, 2017: Canadian Association of Radiologists Journal, Journal L'Association Canadienne des Radiologistes
https://www.readbyqxmd.com/read/28972874/impact-of-sequential-culture-results-on-diagnosis-and-de-escalation-of-the-antibiotic-regimen-in-joint-and-bone-infections
#9
Solen Kernéis, Cécile Leprince, Denis Archambeau, Luc Eyrolle, Philippe Leclerc, Hélène Poupet, Julien Loubinoux, Rémy Gauzit, Dominique Salmon, Odile Launay, Claire Poyart, Philippe Anract, Philippe C Morand
BACKGROUND: According to existing guidelines, orthopedic specimens collected in joint and bone infections (JBI) in our institution are cultured on several media sets and incubated for two, seven, and 14 days. The optimal timing for de-escalation of the first-line antibiotic combination according to the culture results needs to be defined. METHODS: Single-center, retrospective analysis of all adult patients with a first documented episode of JBI between May 2012 and April 2013...
October 3, 2017: Surgical Infections
https://www.readbyqxmd.com/read/28934031/simultaneous-detection-of-15-antibiotic-growth-promoters-in-bovine-muscle%C3%AF-blood-and-urine-by-uplc-ms-ms
#10
Zhi Wang, Zongwei Shi, Cunxian Xi, Guomin Wang, Shurui Cao, Lei Zhang, Bobin Tang, Zhaode Mu
An analytical method was established for the rapid detection of antibiotic growth promoters (AGPs) in bovine muscle, and bovine blood and bovine urine, using ultra high performance liquid chromatography tandem mass spectrometry (UPLC-MS/MS). After the addition of an aqueous solution of EDTA-Na2, the pH of bovine urine samples was directly adjusted to 5.2 by acetic acid-ammonium acetate and purified by HLB solid-phase extraction cartridge; bovine muscle and bovine blood samples processing were extracted with acetonitrile (ACN) and ACN-water (90:10; v/v) without any purification step...
September 21, 2017: Food Additives & Contaminants. Part A, Chemistry, Analysis, Control, Exposure & Risk Assessment
https://www.readbyqxmd.com/read/28913735/efficacy-and-safety-of-tazarotene-0-1-plus-clindamycin-1-gel-versus-adapalene-0-1-plus-clindamycin-1-gel-in-facial-acne-vulgaris-a-randomized-controlled-clinical-trial
#11
Rituparna Maiti, Chandra Sekhar Sirka, M A Ashique Rahman, Anand Srinivasan, Sansita Parida, Debasish Hota
BACKGROUND: Acne vulgaris is a multifactorial disorder which is ideally treated with combination therapy with topical retinoids and antibiotics. OBJECTIVES: The present study was conducted to compare the efficacy and safety of tazarotene plus clindamycin against adapalene plus clindamycin in facial acne vulgaris. METHODS: This study is a randomized, open-label, parallel design clinical trial conducted on 60 patients with facial acne at the outpatient dermatology department in a tertiary healthcare center...
November 2017: Clinical Drug Investigation
https://www.readbyqxmd.com/read/28912911/doxycycline-induced-acute-pancreatitis-a-rare-adverse-event
#12
Prashanth Rawla, Jeffrey Pradeep Raj
Doxycycline is a broad-spectrum antibiotic belonging to the tetracycline group which acts by inhibiting bacterial protein synthesis. It is considered to be a relatively safe drug. We report a case of doxycycline-induced acute pancreatitis (DIAP) in an adult female patient who was started on the usual therapeutic dose 1 week before for acne vulgaris. The WHO causality assessment was possible, and the Naranjo scale confirmed it as "definite" adverse drug reaction. A brief literature review on case reports previously reporting DIAP has also been summarized...
August 2017: Gastroenterology Research
https://www.readbyqxmd.com/read/28911609/antibacterial-and-laxative-activities-of-strictinin-isolated-from-pu-er-tea-camellia-sinensis
#13
Sheng-Kuo Hsieh, Jun-Rui Xu, Nan-Hei Lin, Yue-Chiun Li, Guan-Heng Chen, Ping-Chung Kuo, Wen-Ying Chen, Jason T C Tzen
Strictinin, the major phenolic compound in Pu'er teas produced from young leaves and buds of wild trees, was isolated to evaluate its antibacterial and laxative activities. The minimum inhibitory concentrations of strictinin against Propionibacterium acnes and Staphylococcus epidermidis were determined as 250 μM and 2000 μM, respectively, apparently higher than those of several antibiotics commonly used for bacterial infections. The additive and synergistic effects on the inhibitory activities of strictinin combined with other commercial antibiotics were observed in two bacteria tested in this study via the analysis of fractional inhibitory concentrations...
October 2016: Journal of Food and Drug Analysis
https://www.readbyqxmd.com/read/28884496/potential-role-of-curcumin-against-biofilm-producing-organisms-on-the-skin-a-review
#14
REVIEW
Alexandra R Vaughn, Kelly N Haas, Waqas Burney, Erich Andersen, Ashley K Clark, Robert Crawford, Raja K Sivamani
Turmeric root (Curcuma longa) is predominantly used as a spice, but has also long been known to possess antimicrobial, analgesic, antiinflammatory, and anticancer properties. One predominant group of active compounds in turmeric are curcuminoids, namely bright yellow-pigmented curcumin. While modern science has yet to fully investigate the therapeutic claims of turmeric and its derivatives, results have proven promising in decreasing pain and inflammation in arthritis, improving insulin sensitivity in diabetes, and even curing a variety of infections...
September 7, 2017: Phytotherapy Research: PTR
https://www.readbyqxmd.com/read/28875126/postoperative-deep-shoulder-infections-following-rotator-cuff-repair
#15
REVIEW
Kivanc Atesok, Peter MacDonald, Jeff Leiter, Sheila McRae, Greg Stranges, Jason Old
Rotator cuff repair (RCR) is one of the most commonly performed surgical procedures in orthopaedic surgery. The reported incidence of deep soft-tissue infections after RCR ranges between 0.3% and 1.9%. Deep shoulder infection after RCR appears uncommon, but the actual incidence may be higher as many cases may go unreported. Clinical presentation may include increasing shoulder pain and stiffness, high temperature, local erythema, swelling, warmth, and fibrinous exudate. Generalized fatigue and signs of sepsis may be present in severe cases...
August 18, 2017: World Journal of Orthopedics
https://www.readbyqxmd.com/read/28864554/dietary-supplements-isotretinoin-and-liver-toxicity-in-adolescents-a-retrospective-case-series
#16
Cynthia Marie Carver DeKlotz, Keith D Roby, Sheila Fallon Friedlander
Isotretinoin is the most effective acne therapy available, but has the potential for a number of adverse side effects, including transaminitis. The iPLEDGE isotretinoin program recommends avoiding some herbals and supplements due to potential side effects. However, little is known about the effects of protein supplements on the liver, particularly in patients taking isotretinoin. We designed a retrospective chart review to evaluate the symptoms, diagnosis, treatment, and outcome of patients on or preparing to take isotretinoin therapy who were concurrently ingesting protein or herbal supplementation and who developed transaminitis...
October 2017: Pediatrics
https://www.readbyqxmd.com/read/28842758/utility-of-strain-typing-of-propionibacterium-acnes-in-central-nervous-system-and-prosthetic-joint-infections-to-differentiate-contamination-from-infection-a-retrospective-cohort
#17
J P Burnham, A Shupe, C-A D Burnham, D K Warren
The study aimed to retrospectively assess if strain typing of Propionibacterium acnes could help to distinguish between infection and contamination in isolates recovered from the central nervous system (CNS) and prosthetic joints (PJs). This was a retrospective cohort of all Propionibacterium species isolates from the Barnes-Jewish Hospital (St Louis, MO, USA) clinical microbiology laboratory from 2011 to 2014. Available frozen isolates were recovered, and strain type (IA-1, IA-2, IB, II, III, or nontypeable class A or B) was determined via polymerase chain reaction (PCR)-based methods...
August 25, 2017: European Journal of Clinical Microbiology & Infectious Diseases
https://www.readbyqxmd.com/read/28820275/in-vitro-anti-acne-activity-of-phytoactives-from-the-stem-bark-of-artocarpus-hirsutus-lam-and-characterisation-of-pyranocycloartobiloxanthone-a-as-a-mixture-of-two-anomers
#18
Mahadeva Nayak, A Nagarajan, Muhammed Majeed, Kalyanam Nagabhushanam, Ambar K Choudhury
This study is aimed to isolate the phytoactives from the stem bark of Artocarpus hirsutus and evaluate their in vitro anti-acne activity. The ethanolic stem bark extract of A. hirsutus provided two major phytoactive constituents: (i) pyranocycloartobiloxanthone A, (1) and (ii) Artonine E, (2) whose structures were determined by NMR and MS spectroscopic analysis. The present study is the first to report compound 1 as a mixture of two anomers (α and β), approximately 70:30 ratio. Both compounds 1 and 2 were isolated for the first time from this plant...
August 18, 2017: Natural Product Research
https://www.readbyqxmd.com/read/28794543/synchronizing-pharmacotherapy-in-acne-with-review-of-clinical-care
#19
REVIEW
Sarvajnamurthy Aradhya Sacchidanand, Koushik Lahiri, Kiran Godse, Narendra Gajanan Patwardhan, Anil Ganjoo, Rajendra Kharkar, Varsha Narayanan, Dhammraj Borade, Lyndon D'souza
Acne is a chronic inflammatory skin disease that involves the pathogenesis of four major factors, such as androgen-induced increased sebum secretion, altered keratinization, colonization of Propionibacterium acnes, and inflammation. Several acne mono-treatment and combination treatment regimens are available and prescribed in the Indian market, ranging from retinoids, benzoyl peroxide (BPO), anti-infectives, and other miscellaneous agents. Although standard guidelines and recommendations overview the management of mild, moderate, and severe acne, relevance and positioning of each category of pharmacotherapy available in Indian market are still unexplained...
July 2017: Indian Journal of Dermatology
https://www.readbyqxmd.com/read/28790988/non-antibiotic-isotretinoin-treatment-differentially-controls-propionibacterium-acnes-on-skin-of-acne-patients
#20
Angela E Ryan-Kewley, David R Williams, Neill Hepburn, Ronald A Dixon
Emergence and potential transfer of antibiotic resistance in skin microorganisms is of current concern in medicine especially in dermatology contexts where long term treatment with antibiotics is common. Remarkably, non-antibiotic therapy in the form of isotretinoin - a non-antimicrobial retinoid is effective at reducing or eradicating the anaerobe Propionibacterium acnes which is causally involved in the complex pathogenesis of Acne vulgaris. This study measured the extent of colonization of P. acnes in patients with primary cystic or severe acne from three defined skin sites in 'non-lesion' areas before, during and after treatment with isotretinoin...
2017: Frontiers in Microbiology
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