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https://www.readbyqxmd.com/read/29657463/survey-of-shoulder-arthroplasty-surgeons-methods-for-infection-avoidance-of-propionibacterium
#1
Stephen A Parada, K Aaron Shaw, Josef K Eichinger, Monica J Stadecker, Laurence D Higgins, Jon J P Warner
Introduction: Propionibacterium acnes infection after shoulder arthroplasty remains a source of morbidity. Determining practices amongst shoulder surgeons is the first step in developing infection-prevention best-practices. Methods: A survey was sent to a shoulder fellowship alumni group to determine their arthroplasty infection prevention methods. Results: 74% completed the survey. Cefazolin (90%), vancomycin (50%) and clindamycin (18%) were the most commonly used antibiotics, 61% utilized more than one antibiotic...
March 2018: Journal of Orthopaedics
https://www.readbyqxmd.com/read/29643799/optical-coherence-tomography-examination-of-the-anterior-segment-in-a-case-of-corneal-perforation-and-lens-trauma-by-chestnut-burr
#2
Takashi Ono, Yosai Mori, Ryohei Nejima, Takuya Iwasaki, Shiro Amano, Kazunori Miyata
Chestnut burrs, the thorny encapsulation of chestnut fruit, can sometimes cause corneal injuries and ulceration, with poor prognoses. We report a case of corneal perforation and damaged anterior lens capsule due to a chestnut burr, using anterior segment optical coherence tomography (AS-OCT). A 67-year-old woman with a chestnut burr injury in her right eye was referred to our hospital. Her right best-corrected visual acuity (BCVA) was 0.8. Slit-lamp examination and AS-OCT showed perforation involving the endothelial layer at the center of the cornea...
January 2018: Case Reports in Ophthalmology
https://www.readbyqxmd.com/read/29602922/indicators-of-phagocytosis-in-women-with-acne-during-comprehensive-treatment-that-included-immunotherapy-and-probiotics
#3
Orysya О Syzon, Marianna О Dashko
OBJECTIVE: Introduction: Acne is one of the most common dermatological diseases. It may have a chronic course, leaving permanent marks, and in last years has been tending to have more and more severe clinical course with widespread skin lesions. According to recent studies, the development of acne is due to the combined effect of endogenous and exogenous factors, among which endocrine diseases (quite a significant aspect), disorders of metabolic processes, reduced systemic immunity and phagocytic ability of mononuclear phagocytes and granulocytes at various stages of phagocytosis of pyogenic cocci, which contributes to more severe clinical course, and frequent relapse of this diseases...
2018: Wiadomości Lekarskie: Organ Polskiego Towarzystwa Lekarskiego
https://www.readbyqxmd.com/read/29556985/the-use-of-hormonal-antiandrogen-therapy-in-female-patients-with-acne-a-10-year-retrospective-study
#4
Joyce H Park, Amanda Bienenfeld, Seth J Orlow, Arielle R Nagler
BACKGROUND: Little is known about how dermatologists prescribe hormonal antiandrogen acne treatment (HAAT). OBJECTIVE: The aim of this study was to investigate dermatologists' HAAT-prescribing habits and HAAT's impact on systemic antibiotic use in women with acne. METHODS: We performed a retrospective study at an academic medical center of female patients receiving HAAT (combined oral contraceptive [COC], spironolactone) for acne from January 2005 to October 2015...
March 20, 2018: American Journal of Clinical Dermatology
https://www.readbyqxmd.com/read/29555183/toxic-epidermal-necrolysis-a-dermatologic-emergency-and-the-role-of-the-oral-and-maxillofacial-surgeon
#5
Brian Wolf, Rory Sadoff, Victor Nannini
Toxic epidermal necrolysis (TEN) is a rare and severe mucocutaneous disorder characterized by mucosal and epidermal necrosis and sloughing. This potentially life-threatening condition, together with the less severe Stevens-Johnson syndrome, is commonly caused by an immunologic reaction to medications and can lead to many long-term complications. The disorder initially presents with fever, malaise, and painful mucosal ulcerations (most commonly oral) but progresses to widespread cutaneous lesions. A 14-year-old male patient was prescribed minocycline for treatment of his acne by his primary care doctor...
February 23, 2018: Journal of Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/29544969/cutibacterium-formerly-propionibacterium-avidum-a-rare-but-avid-agent-of-prosthetic-hip-infection
#6
Valérie A Zeller, Valérie-Anne Letembet, Vanina A Meyssonnier, Beate Heym, Jean-Marc Ziza, Simon D Marmor
BACKGROUND: Cutibacterium spp. (formerly Propionibacterium) are slow-growing cutaneous anaerobic commensals, rarely reported in prosthetic joint infections (PJIs). We describe epidemiological, clinical, biological, and radiological characteristics of 15 Cutibacterium avidum PJIs, their treatments, and outcomes. METHODS: This study is an observational, monocenter study (January 2004 to April 2017), with comparison of C avidum vs Cutibacterium acnes (n = 40) PJI characteristics...
February 12, 2018: Journal of Arthroplasty
https://www.readbyqxmd.com/read/29537451/efficacy-and-safety-of-sarecycline-a-novel-once-daily-narrow-spectrum-antibiotic-for-the-treatment-of-moderate-to-severe-facial-acne-vulgaris-results-of-a-phase-2-dose-ranging-study
#7
James J Leyden, Vilma Sniukiene, David R Berk, Alexandre Kaoukhov
BACKGROUND: There is a need for new oral antibiotics for acne with improved safety profiles and targeted antibacterial spectra. Sarecycline is a novel, tetracycline-class antibiotic specifically designed for acne, offering a narrow spectrum of activity compared with currently available tetracyclines, including less activity against enteric Gram-negative bacteria. This phase 2 study evaluated the efficacy and safety of three doses of sarecycline for moderate to severe facial acne vulgaris...
March 1, 2018: Journal of Drugs in Dermatology: JDD
https://www.readbyqxmd.com/read/29537444/efficacy-and-safety-of-adapalene-0-3-benzoyl-peroxide-2-5-gel-plus-oral-doxycycline-in-subjects-with-severe-inflammatory-acne-who-are-candidates-for-oral-isotretinoin
#8
James Q Del Rosso, Linda Stein Gold, Sandra Marchese Johnson, Maria Jose Rueda, Hilary Baldwin, Edward L Lain, Megan Landis, Marta Rendon, Emil Tanghetti, Jonathan Weiss
INTRODUCTION: Acne treatment guidelines suggest a combination approach with topical therapy including a topical retinoid, benzoyl peroxide and an oral antibiotic, or oral isotretinoin (OI), as first-line treatment options for severe acne vulgaris (AV). This study evaluated the efficacy and safety of a daily regimen of 0.3% adapalene and 2.5% benzoyl peroxide (0.3% A/BPO) gel and oral doxycycline 100 mg twice daily in severe (nonnodulocystic, non-conglobate) inflammatory AV. METHODS: This was a phase 4, 12-week, single-arm, openlabel, multi-center investigational study...
March 1, 2018: Journal of Drugs in Dermatology: JDD
https://www.readbyqxmd.com/read/29511361/late-presentation-of-infected-silicone-granulomas-in-the-lower-limb
#9
Zita M Jessop, Matthew Welck, Emily Zinser, Nicholas Garlick, Susan Hopkins
Introduction: Dermal fillers are used for multiple cosmetic indications including gluteal and thigh augmentation. Complications, although infrequent, are increasing due to the dramatic growth of dermal filler use. Our aim was to describe how the complication of infected silicone granulomas can present following lower limb augmentation. Methods: Two cases presented with pain, oedema, and erythema at the site of previous silicone filler injection, following a considerable delay after the last injection (range 4-7 years)...
2018: Clinical Medicine Insights. Arthritis and Musculoskeletal Disorders
https://www.readbyqxmd.com/read/29499825/antibiotic-prophylaxis-and-prevention-of-surgical-site-infection-in-shoulder-and-elbow-surgery
#10
REVIEW
K Keely Boyle, Thomas R Duquin
Infection after orthopedic procedures is a devastating and serious complication associated with significant clinical and financial challenges to the health care system and unfortunate patient. The time and resource-intensive nature of treating infection after orthopedic procedures has turned attention toward enhancing prevention and establishing quality improvement measures. Prevention strategies throughout the perioperative period include host optimization, risk mitigation, reducing bacterial burden and proper wound management...
April 2018: Orthopedic Clinics of North America
https://www.readbyqxmd.com/read/29497567/c1-c2-arthrodesis-after-spontaneous-propionibacterium-acnes-spondylodiscitis-case-report-and-literature-analysis
#11
Paolo di Russo, Carlo Tascini, Maria Elena Benini, Carlotta Martini, Paolo Lepori
Background: Propionibacterium acnes ( P. acnes ) is a microaerophilic anaerobic Gram-positive rod responsible for acne vulgaris. Although it is often considered to be a skin contaminant, it may act as a virulent agent in implant-associated infections. Conversely, spontaneous infectious processes have been rarely described. Case Description: Here, we describe a 43-year-old female with C1-C2 spondylodiscitis attributed to P. acnes infection. Despite long-term antibiotic treatment, computed tomography demonstrated erosion of the C1 and C2 vertebral complex that later warranted a fusion...
2018: Surgical Neurology International
https://www.readbyqxmd.com/read/29490312/case-reports-of-acne-and-homeopathy
#12
Lawrence C Nwabudike
BACKGROUND: Acne vulgaris is a self-limiting disorder of the pilosebaceous unit. The aesthetic aspect of the disorder may provoke depression and diminish the quality of life. A number of agents are used for acne treatment, e.g., retinoids, antibiotics, benzoic acid, azelaic acid, and hormones. These agents have side-effects, sometimes severe ones. CASE REPORTS: Presented are 2 cases of severe acne treated with individualized homeopathic medicines. Both patients were treated using the classical method of homeopathy, i...
2018: Complementary Medicine Research
https://www.readbyqxmd.com/read/29490060/actual-versus-ideal-antibiotic-prescribing-for-common-conditions-in-english-primary-care
#13
Koen B Pouwels, F Christiaan K Dolk, David R M Smith, Julie V Robotham, Timo Smieszek
Objectives: Previous work based on guidelines and expert opinion identified 'ideal' prescribing proportions-the overall proportion of consultations that should result in an antibiotic prescription-for common infectious conditions. Here, actual condition-specific prescribing proportions in primary care in England were compared with ideal prescribing proportions identified by experts. Methods: All recorded consultations for common infectious conditions (cough, bronchitis, exacerbations of asthma or chronic obstructive pulmonary disease, sore throat, rhinosinusitis, otitis media, lower respiratory tract infection, upper respiratory tract infection, influenza-like illness, urinary tract infection, impetigo, acne, gastroenteritis) for 2013-15 were extracted from The Health Improvement Network (THIN) database...
February 1, 2018: Journal of Antimicrobial Chemotherapy
https://www.readbyqxmd.com/read/29486354/an-in-vivo-evaluation-of-microbial-diversity-before-and-after-the-photo-activated-disinfection-in-primary-endodontic-infections-traditional-phenotypic-and-molecular-approaches
#14
Maryam Pourhajibagher, Abbas Bahador
BACKGROUND: It is essential to identify the root canal microbial diversity and count due to the polymicrobial nature of the primary endodontic infection that is associated with the microbial diversity and increased resistance to the antimicrobial agents. Photo-activated disinfection (PAD), also known as antimicrobial photodynamic therapy, is a new promising non-antibiotic approach, studied to prevent microbial resistance and treatment failure. MATERIALS AND METHODS: In this study, we investigated the effect of PAD on reduction of microbial diversity and count, related with primary endodontic infections...
February 24, 2018: Photodiagnosis and Photodynamic Therapy
https://www.readbyqxmd.com/read/29472269/understanding-the-gender-gap-in-antibiotic-prescribing-a-cross-sectional-analysis-of-english-primary-care
#15
David R M Smith, F Christiaan K Dolk, Timo Smieszek, Julie V Robotham, Koen B Pouwels
OBJECTIVES: To explore the causes of the gender gap in antibiotic prescribing, and to determine whether women are more likely than men to receive an antibiotic prescription per consultation. DESIGN: Cross-sectional analysis of routinely collected electronic medical records from The Health Improvement Network (THIN). SETTING: English primary care. PARTICIPANTS: Patients who consulted general practices registered with THIN between 2013 and 2015...
February 22, 2018: BMJ Open
https://www.readbyqxmd.com/read/29459223/ambulatory-practice-of-dermatologists-in-taiwan-a-nationwide-survey
#16
Ying-Xiu Dai, Tzeng-Ji Chen, Yun-Ting Chang
BACKGROUND: Skin diseases are among the most common public health problems and cause a significant burden. For policymakers and clinicians, comprehensive and detailed information is necessary to better allocate resources needed to care for skin diseases. This study was conducted to characterize the ambulatory practice of dermatologists in Taiwan. METHODS: The study data were drawn from the datasets of Taiwan's National Health Insurance Research Database for 2013, with 623,614 records of ambulatory care visits representing 1/500 of all the claims in Taiwan for 2013...
February 16, 2018: Journal of the Chinese Medical Association: JCMA
https://www.readbyqxmd.com/read/29444375/the-efficacy-and-safety-of-non-pharmacological-therapies-for-the-treatment-of-acne-vulgaris-a-systematic-review-and-best-evidence-synthesis
#17
F M C de Vries, A M Meulendijks, R J Driessen, A A van Dooren, E P M Tjin, P C M van de Kerkhof
BACKGROUND: Acne vulgaris is a multifaceted skin disorder, affecting more than 85% of young individuals worldwide. Pharmacological therapy is not always desirable because of the development of antibiotic resistance or the potential risk of adverse effects. Non-pharmacological therapies can be viable alternatives for conventional therapies. However, sufficient evidence based support in the efficacy and safety of non-pharmacological therapies is lacking. OBJECTIVE: To assess the efficacy and safety of several non-pharmacological therapies in the treatment of acne vulgaris...
February 14, 2018: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/29409921/a-rationally-designed-multifunctional-antibiotic-for-the-treatment-of-drug-resistant-acne
#18
Sumana Ghosh, Mau Sinha, Anamika Bhattacharyya, Suresh Sadhasivam, Jayasundarnaidu Megha, Sreedhar Reddy, Swamini Saini, Himanshi Singh, Deepak Kumar, Simar Preet Kaur, Mallika Mishra, Dandamudi Usharani, Shamik Ghosh, Shiladitya Sengupta
Acne is a multifactorial skin disease, underpinned by colonization of Propionibacterium acnes and inflammation. The emergence of resistant P. acnes strains has affected the current acne treatment algorithm. This setback served as an impetus for rationally designing a library of next-generation antibiotics that exhibit a bactericidal effect on resistant P. acnes and exert an immunomodulatory function to reduce inflammation. In silico screening showed that one of the molecules, VCD-004, exhibits improved mode of binding to bacterial DNA gyrase...
January 31, 2018: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/29400580/picosecond-alexandrite-laser-is-superior-to-q-switched-nd-yag-laser-in-treatment-of-minocycline-induced-hyperpigmentation-a-case-study-and-review-of-the-literature
#19
Tom Barrett, Sally de Zwaan
Minocycline is a commonly prescribed tetracycline antibiotic used for the treatment of a number of dermatological conditions including acne and rosacea. Long-term adverse effects of minocycline include cutaneous hyperpigmentation. Various treatment options have been suggested for the treatment of minocycline pigmentation. We report a case of a patient on long-term low-dose minocycline for the treatment of rosacea with type III minocycline hyperpigmentation. A comparison was made between Q-Switch Nd:YAG and picosecond laser over a nine 9-period with treatments spaced 1 month apart, with a clearance in the patient pigmentation after four treatments with picosecond laser...
February 5, 2018: Journal of Cosmetic and Laser Therapy: Official Publication of the European Society for Laser Dermatology
https://www.readbyqxmd.com/read/29373772/-periodontal-microbiota-and-microorganisms-isolated-from-heart-valves-in-patients-undergoing-valve-replacement-surgery-in-a-clinic-in-cali-colombia
#20
Sandra Moreno, Beatriz Parra, Javier E Botero, Freddy Moreno, Daniel Vásquez, Hugo Fernández, Sandra Alba, Sara Gallego, Gilberto Castillo, Adolfo Contreras
INTRODUCTION: Periodontitis is an infectious disease that affects the support tissue of the teeth and it is associated with different systemic diseases, including cardiovascular disease. Microbiological studies facilitate the detection of microorganisms from subgingival and cardiovascular samples. OBJECTIVE: To describe the cultivable periodontal microbiota and the presence of microorganisms in heart valves from patients undergoing valve replacement surgery in a clinic in Cali...
December 1, 2017: Biomédica: Revista del Instituto Nacional de Salud
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