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https://www.readbyqxmd.com/read/28097676/morbihan-disease-complicated-by-dermatosis-neglecta-a-unique-presentation
#1
Ariel E Eber, Stephanie Mlacker, Sebastian Verne, Robert Griffith, Jennifer Ledon, Marina Perper, Keyvan Nouri, Jeong Hee Cho-Vega
Morbihan disease (MD), also referred to as solid facial edema, or rosacea lymphedema, is a rare disorder that involves chronic erythema and solid edema of the cheeks, eyelids, forehead and glabella and may arise as a complication of acne vulgaris or rosacea. Of note, it may be the only initial presenting symptom of these associated diseases.1,2 Few cases have been described in the literature, since its first description by Robert Degos in 1957. The condition is characterized by its chronicity, a typical clinical appearance, and the lack of specific histopathologic or laboratory findings...
January 18, 2017: Journal of Cutaneous Pathology
https://www.readbyqxmd.com/read/28095556/combination-therapy-for-acne-scarring-personal-experience-and-clinical-suggestions
#2
Lucija Kroepfl, Jason J Emer
Acne is one of the most prevalent skin conditions seen by dermatologists. The cosmetic sequelae of severe acne, including scarring and pigmentation, have a profound psychological impact on those in icted. Topical (eg, retinoids, antibiotics, dapsone, hydroxyacids) and oral treatments (eg, antibiotics and/or spironolactone) are often bene cial to control acne or in the instance of oral isotretinoin use, rid the acne permanently; however, these treatments have very little affect on the ultimate cosmetic outcome of the acne scarring and skin texture that results...
November 1, 2016: Journal of Drugs in Dermatology: JDD
https://www.readbyqxmd.com/read/28095537/spotlight-on-the-use-of-nitric-oxide-in-dermatology-what-is-it-what-does-it-do-can-it-become-an-important-addition-to-the-therapeutic-armamentarium-for-skin-disease
#3
James Q Del Rosso, Leon H Kircik
Nitric oxide (NO) is a diatomic gas that is synthesized within and released by multiple host cell types functioning to provide a variety of physiologic and homeostatic effects. Nitric oxide exhibits a variety of effects that relate significantly with outcomes that can provide therapeutic benefit if properly formulated and released. These include anti-inflammatory, immunomodulatory, antimicrobial, vasodilatory properties, and effects that are beneficial to wound healing. Lack of antibiotic resistance appears to be one major advantage of topically delivered NO...
January 1, 2017: Journal of Drugs in Dermatology: JDD
https://www.readbyqxmd.com/read/28094874/skin-microbiome-and-acne-vulgaris-staphylococcus-a-new-actor-in-acne
#4
Brigitte Dreno, Richard Martin, Dominique Moyal, Jessica B Henley, Amir Khammari, Sophie Seité
: Propionibacterium acnes (P. acnes), the sebaceous gland and follicular keratinocytes are considered the three actors involved in the development of acne. This exploratory study investigated the characteristics of the skin microbiota in subjects with acne and determined microbiota changes after 28 days of application of erythromycin 4% or a dermocosmetic. Skin Microbiota were collected under axenic conditions from comedones, papulo-pustular lesions and nonlesional skin areas from subjects with mild to moderate acne according to the GEA Grading using swabs...
January 17, 2017: Experimental Dermatology
https://www.readbyqxmd.com/read/28087166/future-surgery-after-revision-shoulder-arthroplasty-the-impact-of-unexpected-positive-cultures
#5
Eric M Padegimas, Cassandra Lawrence, Alexa C Narzikul, Benjamin M Zmistowski, Joseph A Abboud, Gerald R Williams, Surena Namdari
BACKGROUND: The clinical implications and treatment of unexpected positive cultures (UPCs) in revision shoulder arthroplasty are not well defined. The purpose of this study was to describe results of patients with and without UPCs after revision shoulder arthroplasty. METHODS: A single institutional database was used to retrospectively identify all revision shoulder arthroplasties performed between January 1, 2011, and December 31, 2013. Patients with preoperative suspicion of infection were excluded...
January 10, 2017: Journal of Shoulder and Elbow Surgery
https://www.readbyqxmd.com/read/27996153/antibiotics-and-acne-an-emerging-iceberg-of-antibiotic-resistance
#6
EDITORIAL
S-J Sinnott, K Bhate, D J Margolis, S M Langan
No abstract text is available yet for this article.
December 2016: British Journal of Dermatology
https://www.readbyqxmd.com/read/27989720/prevention-of-propionibacterium-acnes-biofilm-formation-in-prosthetic-infections-in-vitro
#7
Robert P Howlin, Christopher Winnard, Elizabeth M Angus, Connor J Frapwell, Jeremy S Webb, John J Cooper, Sean S Aiken, Julie Y Bishop, Paul Stoodley
BACKGROUND: The role of Propionibacterium acnes in shoulder arthroplasty and broadly in orthopedic prosthetic infections has historically been underestimated, with biofilm formation identified as a key virulence factor attributed to invasive isolates. With an often indolent clinical course, P acnes infection can be difficult to detect and treat. This study investigates absorbable cements loaded with a broad-spectrum antibiotic combination as an effective preventive strategy to combat P acnes biofilms...
December 15, 2016: Journal of Shoulder and Elbow Surgery
https://www.readbyqxmd.com/read/27984454/nonunion-after-clavicle-osteosynthesis-high-incidence-of-propionibacterium-acnes
#8
Elizabeth B Gausden, Jordan Villa, Stephen J Warner, Mariya Redko, Andrew Pearle, Andy Miller, Michael Henry, Dean G Lorich, David L Helfet, David S Wellman
OBJECTIVE: The objective of this study was to review the etiology of clavicle nonunions following osteosynthesis and investigate the outcomes of a treatment with a single stage revision. DESIGN: Retrospective case series SETTING:: Orthopaedic specialty hospital PATIENTS:: Twenty cases of nonunion following osteosynthesis of the clavicle were identified. The average age was 44 years old (+/- 13 years). In nine cases there was catastrophic implant failure that prompted the revision surgery...
December 8, 2016: Journal of Orthopaedic Trauma
https://www.readbyqxmd.com/read/27976439/prospective-multicentre-cohort-study-on-9154-surgical-procedures-to-assess-the-risk-of-postoperative-bleeding-a-dessi-study
#9
W Koenen, C Kunte, D Hartmann, H Breuninger, M Moehrle, F G Bechara, H J Schulze, A Lösler, C R Löser, T Wetzig, D Pappai, S Rapprich, C Weiß, J Faulhaber
BACKGROUND: To date, there is still a debate how to deal with patients receiving antithrombotic agents prior to surgical procedures on the skin. OBJECTIVE: To prospectively assess complications after dermatosurgical interventions, especially bleeding, depending on anticoagulation therapy. METHODS: Patients underwent surgery consecutively as scheduled, without randomization, whether or not they were currently taking anticoagulants. Nine institutions of the DESSI (DErmatoSurgical Study Initiative) working group documented patient data prospectively on a standardized study sheet prior to and after 9154 dermatosurgical interventions...
December 15, 2016: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/27896620/antimicrobial-activity-of-topical-agents-against-propionibacterium-acnes-an-in-vitro-study-of-clinical-isolates-from-a-hospital-in-shanghai-china
#10
Ying Ma, Nanxue Zhang, Shi Wu, Haihui Huang, Yanpei Cao
This study aimed to compare the antimicrobial activities of topical agents against Propionibacterium acnes isolated from patients admitted to a hospital in Shanghai, China. The minimal inhibitory concentrations of the cultured P. acnes were determined in accordance with the Clinical and Laboratory Standards Institute. Susceptibilities to clindamycin and erythromycin were compared in terms of gender, age, disease duration, previous treatment, and disease severity. A total of 69 P. acnes strains were isolated from 98 patients (70...
November 28, 2016: Frontiers of Medicine
https://www.readbyqxmd.com/read/27890236/the-critical-and-multifunctional-roles-of-antimicrobial-peptides-in-dermatology
#11
REVIEW
Toshiya Takahashi, Richard L Gallo
Antimicrobial peptides are central effector molecules in skin immunology. The functions of antimicrobial peptides in skin diseases include the ability to act as cytokines or growth factors, driving disorders such as psoriasis and rosacea, as well as their action as natural antibiotics to control bacteria that influence diseases such as atopic dermatitis and acne.
January 2017: Dermatologic Clinics
https://www.readbyqxmd.com/read/27888792/case-study-an-intraoperative-finding-of-black-bone-disease-in-a-podiatric-surgery-patient
#12
Robyn L Carter-Wale, Trevor D Prior
Black bone disease has been recognised as a potential consequence of long-term treatment with tetracycline antibiotics. Largely documented affecting structures in the head and skull, there are few reported cases of black bone disease in the foot and ankle. The case of a 55 years old patient, who as a teenager, had undergone treatment with minocycline hydrochloride for chronic acne, and was found to have bone discolouration consistent with minocycline induced black bone disease (MIBBD) during the course of hallux valgus corrective surgery some 40 years later, is presented...
December 2016: Foot
https://www.readbyqxmd.com/read/27887873/neer-award-2017-a-rapid-method-for-detecting-propionibacterium-acnes-in-surgical-biopsy-specimens-from-the-shoulder
#13
Scott Holmes, Ana M Pena Diaz, George S Athwal, Kenneth J Faber, David B O'Gorman
BACKGROUND: Propionibacterium (P) acnes infection of the shoulder after arthroplasty is a common and serious complication. Current detection methods for P acnes involve anaerobic cultures that require prolonged incubation periods (typically 7-14 days). We have developed a polymerase chain reaction (PCR)-restriction fragment length polymorphism (RFLP) approach that sensitively and specifically identifies P acnes in tissue specimens within a 24-hour period. METHODS: Primers were designed to amplify a unique region of the 16S rRNA gene in P acnes that contained a unique HaeIII restriction enzyme site...
November 22, 2016: Journal of Shoulder and Elbow Surgery
https://www.readbyqxmd.com/read/27879178/-minocycline-induced-hyperpigmentation-not-uncommon-but-nonetheless-important-to-recognise
#14
P J G M Voets, D Blommaert, R R M C Keijsers, H A C Alkemade
BACKGROUND: Minocycline, a broad-spectrum antibiotic from the group of tetracyclins, is frequently prescribed for acne vulgaris and rosacea. Hyperpigmentation is a relatively common side effect of this drug and can lead to multiple unsightly skin lesions, which are not always reversible. It can take a long period, from a few months to several years, before the lesions have completely vanished. CASE DESCRIPTION: A 24-year-old male was seen in our outpatient clinic because of slowly progressive pigmented lesions on his shins...
2016: Nederlands Tijdschrift Voor Geneeskunde
https://www.readbyqxmd.com/read/27863184/lipase-sensitive-transfersomes-based-on-photosensitizer-polymerizable-lipid-conjugate-for-selective-antimicrobial-photodynamic-therapy-of-acne
#15
Hyung Park, Jonghwan Lee, Songhee Jeong, Byeong Nam Im, Min-Kyoung Kim, Su-Geun Yang, Kun Na
Acne vulgaris is a common skin problem affecting nearly 90% of adolescents and its development is associated with a colonization of Propionibacterium acnes (P. acnes). Although antibiotics have commonly been used to treat acne, antibiotic resistance of P. acnes is an emerging issue to be solved. In this study, a new way of photodynamic acne therapy is developed using P. acnes lipase-sensitive transfersome (DSPE-PEG-Pheo A (DPP) transfersome). For enhanced selectivity and skin penetration efficiency, DPP transfersomes are prepared from 1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-[amino(polyethylene glycol)-2000], pheophorbide A (Pheo A), cholesterol, and Tween-80...
December 2016: Advanced Healthcare Materials
https://www.readbyqxmd.com/read/27853192/doxycycline-metronidazole-and-isotretinoin-do-they-modify-microrna-mrna-expression-profiles-and-function-in-murine-t-cells
#16
Eugenia Becker, Susan Bengs, Sirisha Aluri, Lennart Opitz, Kirstin Atrott, Claudia Stanzel, Pedro A Ruiz Castro, Gerhard Rogler, Isabelle Frey-Wagner
Inflammatory bowel disease (IBD) may develop due to an inflammatory response to commensal gut microbiota triggered by environmental factors in a genetically susceptible host. Isotretinoin (acne therapy) has been inconsistently associated with IBD onset and flares but prior treatment with antibiotics, also associated with IBD development, complicates the confirmation of this association. Here we studied in mice whether doxycycline, metronidazole or isotretinoin induce epigenetic modifications, and consequently change T-cell mRNA expression and/or function directly after treatment and after a 4 week recovery period...
November 17, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27848173/assessing-pharmacists-readiness-to-prescribe-oral-antibiotics-for-limited-infections-using-a-case-vignette-technique
#17
Elizabeth Ung, Petra Czarniak, Bruce Sunderland, Richard Parsons, Kreshnik Hoti
Background Pharmacist's skills are underutilized whilst they are directly involved with antibiotic supply to the community. Addressing this issue could lead to better use of antibiotics and hence decreased resistance. Objective Explore how pharmacists can prescribe oral antibiotics to treat a limited range of infections whilst focusing on their confidence and appropriateness of prescribing. Setting Community pharmacies, Western Australia. Method Data were collected using a self-administered questionnaire also containing case vignettes...
November 15, 2016: International Journal of Clinical Pharmacy
https://www.readbyqxmd.com/read/27829959/propionibacterium-acnes-time-to-positivity-in-standard-bacterial-culture-from-different-anatomical-sites
#18
Rasha Abdulmassih, Jina Makadia, James Como, Michelle Paulson, Zaw Min, Nitin Bhanot
BACKGROUND: Propionibacterium acnes infections are likely under-recognized and underreported. This is partly because of low clinical suspicion, perceived non-pathogenicity, or lack of adequate culture incubation time. We conducted a study to assess the optimal incubation period to recover P. acnes from specimens acquired during the workup of suspected clinical infections. METHODS: A 5-year retrospective chart review was conducted between January 2010 and December 2014 at a single tertiary-care hospital...
December 2016: Journal of Clinical Medicine Research
https://www.readbyqxmd.com/read/27829389/chronic-post-operative-iris-prosthesis-endophthalmitis-in-a-patient-with-traumatic-aniridia-a-case-report
#19
Kevin C Firl, Sandra R Montezuma
BACKGROUND: Post-operative endophthalmitis is a serious complication of intraocular surgery which may present acutely or chronically. Chronic post-operative endophthalmitis is characterized by decreased visual acuity, mild pain, and low-grade uveitis several weeks or months after intraocular surgery which may be responsive to corticosteroids, but recur upon tapering. Low virulence organisms such as Propionibacterium acnes are the most common culprit organisms, and treatment most often consists of both intravitreal antibiotic injections and surgery...
November 9, 2016: BMC Ophthalmology
https://www.readbyqxmd.com/read/27822528/urban-transit-system-microbial-communities-differ-by-surface-type-and-interaction-with-humans-and-the-environment
#20
Tiffany Hsu, Regina Joice, Jose Vallarino, Galeb Abu-Ali, Erica M Hartmann, Afrah Shafquat, Casey DuLong, Catherine Baranowski, Dirk Gevers, Jessica L Green, Xochitl C Morgan, John D Spengler, Curtis Huttenhower
Public transit systems are ideal for studying the urban microbiome and interindividual community transfer. In this study, we used 16S amplicon and shotgun metagenomic sequencing to profile microbial communities on multiple transit surfaces across train lines and stations in the Boston metropolitan transit system. The greatest determinant of microbial community structure was the transit surface type. In contrast, little variation was observed between geographically distinct train lines and stations serving different demographics...
May 2016: MSystems
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