keyword
MENU ▼
Read by QxMD icon Read
search

Bacteria, antibiotic resistance

keyword
https://www.readbyqxmd.com/read/29054003/adhesion-force-sensing-and-activation-of-a-membrane-bound-sensor-to-activate-nisin-efflux-pumps-in-staphylococcus-aureus-under-mechanical-and-chemical-stresses
#1
Vera Carniello, Akshay K Harapanahalli, Henk J Busscher, Henny C van der Mei
Nisin-associated-sensitivity-response-regulator (NsaRS) in Staphylococcus aureus is important for its adhesion to surfaces and resistance against antibiotics, like nisin. NsaRS consists of an intra-membrane-located sensor NsaS and a cytoplasmatically-located response-regulator NsaR, which becomes activated upon receiving phosphate groups from the intra-membrane-located sensor. HYPOTHESIS: The intra-membrane location of the NsaS sensor leads us to hypothesize that the two-component NsaRS system not only senses "chemical" (nisin) but also "mechanical" (adhesion) stresses to modulate efflux of antibiotics from the cytoplasm...
October 7, 2017: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/29052326/effects-of-the-antimicrobial-peptide-protegrine-1-on-sperm-viability-and-bacterial-load-of-boar-seminal-doses
#2
S Sancho, M Briz, M Yeste, S Bonet, E Bussalleu
The presence of bacteria adversely affects boar sperm quality of seminal doses intended for artificial insemination. Currently, the most common measure to prevent bacteriospermia is the addition of antibiotics in semen extenders; however, mounting evidence shows that microbial resistance exists. A promising alternative to replace antibiotics are antimicrobial peptides. In this study, the effects of the antimicrobial peptide protegrine 1 (PG1) on the sperm viability and bacterial load of boar seminal doses were evaluated...
October 2017: Reproduction in Domestic Animals, Zuchthygiene
https://www.readbyqxmd.com/read/29051379/ectopic-colonization-of-oral-bacteria-in-the-intestine-drives-th1-cell-induction-and-inflammation
#3
Koji Atarashi, Wataru Suda, Chengwei Luo, Takaaki Kawaguchi, Iori Motoo, Seiko Narushima, Yuya Kiguchi, Keiko Yasuma, Eiichiro Watanabe, Takeshi Tanoue, Christoph A Thaiss, Mayuko Sato, Kiminori Toyooka, Heba S Said, Hirokazu Yamagami, Scott A Rice, Dirk Gevers, Ryan C Johnson, Julia A Segre, Kong Chen, Jay K Kolls, Eran Elinav, Hidetoshi Morita, Ramnik J Xavier, Masahira Hattori, Kenya Honda
Intestinal colonization by bacteria of oral origin has been correlated with several negative health outcomes, including inflammatory bowel disease. However, a causal role of oral bacteria ectopically colonizing the intestine remains unclear. Using gnotobiotic techniques, we show that strains of Klebsiella spp. isolated from the salivary microbiota are strong inducers of T helper 1 (TH1) cells when they colonize in the gut. These Klebsiella strains are resistant to multiple antibiotics, tend to colonize when the intestinal microbiota is dysbiotic, and elicit a severe gut inflammation in the context of a genetically susceptible host...
October 20, 2017: Science
https://www.readbyqxmd.com/read/29050760/mmps5-mmpl5-as-an-efflux-pump-in-mycobacterium-species
#4
REVIEW
Julien Briffotaux, Wei Huang, Xinwei Wang, Brigitte Gicquel
Tuberculosis remains an important cause of morbidity and mortality throughout the world, amplified by the expansion of antibiotic resistance. Increasing active efflux of the antibiotic is one of the several strategies used by bacteria to resist to antibiotics. After showing the importance of the RND superfamily of efflux pumps in drug resistance, this review focuses on the protein MmpL5, a transmembrane transporter of Mycobacterium. These exporters should be involved in the variety of roles in bacterial cells, including expelling various drugs...
December 2017: Tuberculosis
https://www.readbyqxmd.com/read/29049953/biomimetic-fabrication-of-antibacterial-calcium-phosphates-mediated-by-polydopamine
#5
Lucia Forte, Paola Torricelli, Francesca Bonvicini, Elisa Boanini, Giovanna Angela Gentilomi, Gigliola Lusvardi, Elena Della Bella, Milena Fini, Edoardo Vecchio Nepita, Adriana Bigi
In this work we developed new antibacterial composite materials using polydopamine (PDA) to trigger the deposition of silver nanoparticles (AgNPs) onto calcium phosphates, namely octacalcium phosphate (OCP) and α-tricalcium phosphate (αTCP). Functionalization of OCP and αTCP with a self-polymerized polydopamine layer was obtained by soaking the calcium phosphates in dopamine solution. The PDA surface of functionalized calcium phosphates (OCPd and αTCPd) promoted the deposition of AgNPs by reducing silver ions when soaked in a silver nitrate solution...
October 10, 2017: Journal of Inorganic Biochemistry
https://www.readbyqxmd.com/read/29049010/biofilm-related-diseases-and-omics-global-transcriptional-profiling-of-enterococcus-faecium-reveals-different-gene-expression-patterns-in-the-biofilm-and-planktonic-cells
#6
Shu Yong Lim, Cindy Shuan Ju Teh, Kwai Lin Thong
Enterococcus faecium is an opportunistic pathogen with a remarkable ability to acquire resistance toward multiple antibiotics, including those of last-resort drugs such as vancomycin and daptomycin. The occurrence of vancomycin-resistant E. faecium is on the rise and there is a need to understand the virulence of this organism. One of the factors that contributes to the virulence is the ability to form biofilms. Since bacteria in biofilm state are more resistant to antibiotics and host immune response, understanding the molecular mechanism of biofilm development is important to control biofilm-related diseases...
October 2017: Omics: a Journal of Integrative Biology
https://www.readbyqxmd.com/read/29047329/genome-sequencing-of-39-akkermansia-muciniphila-isolates-reveals-its-population-structure-genomic-and-functional-diverisity-and-global-distribution-in-mammalian-gut-microbiotas
#7
Xianfeng Guo, Shenghui Li, Jiachun Zhang, Feifan Wu, Xiangchun Li, Dan Wu, Min Zhang, Zihao Ou, Zhuye Jie, Qiulong Yan, Peng Li, Jiangfeng Yi, Yongzheng Peng
BACKGROUND: Akkermansia muciniphila is one of the most dominant bacteria that resides on the mucus layer of intestinal tract and plays key role in human health, however, little is known about its genomic content. RESULTS: Herein, we for the first time characterized the genomic architecture of A. muciniphila based on whole-genome sequencing, assembling, and annotating of 39 isolates derived from human and mouse feces. We revealed a flexible open pangenome of A. muciniphila currently consisting of 5644 unique proteins...
October 18, 2017: BMC Genomics
https://www.readbyqxmd.com/read/29046782/assessment-of-the-potential-for-resistance-to-antimicrobial-violet-blue-light-in-staphylococcus-aureus
#8
Rachael M Tomb, Michelle Maclean, John E Coia, Scott J MacGregor, John G Anderson
BACKGROUND: Antimicrobial violet-blue light in the region of 405 nm is emerging as an alternative technology for hospital decontamination and clinical treatment. The mechanism of action is the excitation of endogenous porphyrins within exposed microorganisms, resulting in ROS generation, oxidative damage and cell death. Although resistance to 405 nm light is not thought likely, little evidence has been published to support this. This study was designed to establish if there is potential for tolerance development, using the nosocomial pathogen Staphylococcus aureus as the model organism...
2017: Antimicrobial Resistance and Infection Control
https://www.readbyqxmd.com/read/29046693/antibacterial-activity-of-essential-oil-from-lavender-lavandula-angustifolia-against-pet-turtle-borne-pathogenic-bacteria
#9
Sabrina Hossain, Honghoi Heo, B C J De Silva, S H M P Wimalasena, H N K S Pathirana, Gang-Joon Heo
Pet turtles are well-known to harbor an array of bacterial pathogens which can cause zoonotic infections in humans as well as opportunistic infections in the turtles itself. Essential oils are the natural plant extracts which have been traditionally used for disease treatment. In the present study, the essential oil of lavender (EOL) was examined for its antibacterial activity against thirty-eight strains of turtle-borne pathogenic bacteria belonging to seven species; Aeromonas hydrophila, A. caviae, A. dhakensis, Citrobacter freundii, Proteus mirabilis, Salmonella enterica and Pseudomonas aeruginosa...
September 2017: Laboratory Animal Research
https://www.readbyqxmd.com/read/29046540/compensatory-mutations-improve-general-permissiveness-to-antibiotic-resistance-plasmids
#10
Wesley Loftie-Eaton, Kelsie Bashford, Hannah Quinn, Kieran Dong, Jack Millstein, Samuel Hunter, Maureen K Thomason, Houra Merrikh, Jose M Ponciano, Eva M Top
Horizontal gene transfer mediated by broad-host-range plasmids is an important mechanism of antibiotic resistance spread. While not all bacteria maintain plasmids equally well, plasmid persistence can improve over time, yet no general evolutionary mechanisms have emerged. Our goal was to identify these mechanisms and to assess if adaptation to one plasmid affects the permissiveness to others. We experimentally evolved Pseudomonas sp. H2 containing multidrug resistance plasmid RP4, determined plasmid persistence and cost using a joint experimental-modelling approach, resequenced evolved clones, and reconstructed key mutations...
September 2017: Nature ecology & evolution
https://www.readbyqxmd.com/read/29045862/the-two-state-prehensile-tail-of-the-antibacterial-toxin-colicin-n
#11
Christopher L Johnson, Alexandra S Solovyova, Olli Hecht, Colin Macdonald, Helen Waller, J Günter Grossmann, Geoffrey R Moore, Jeremy H Lakey
Intrinsically disordered regions within proteins are critical elements in many biomolecular interactions and signaling pathways. Antibacterial toxins of the colicin family, which could provide new antibiotic functions against resistant bacteria, contain disordered N-terminal translocation domains (T-domains) that are essential for receptor binding and the penetration of the Escherichia coli outer membrane. Here we investigate the conformational behavior of the T-domain of colicin N (ColN-T) to understand why such domains are widespread in toxins that target Gram-negative bacteria...
October 17, 2017: Biophysical Journal
https://www.readbyqxmd.com/read/29045498/novel-drug-targets-in-cell-wall-biosynthesis-exploited-by-gene-disruption-in-pseudomonas-aeruginosa
#12
Ayssar A Elamin, Susanne Steinicke, Wulf Oehlmann, Yvonne Braun, Hanaa Wanas, Eduard A Shuralev, Carmen Huck, Marko Maringer, Manfred Rohde, Mahavir Singh
For clinicians, Pseudomonas aeruginosa is a nightmare pathogen that is one of the top three causes of opportunistic human infections. Therapy of P. aeruginosa infections is complicated due to its natural high intrinsic resistance to antibiotics. Active efflux and decreased uptake of drugs due to cell wall/membrane permeability appear to be important issues in the acquired antibiotic tolerance mechanisms. Bacterial cell wall biosynthesis enzymes have been shown to be essential for pathogenicity of Gram-negative bacteria...
2017: PloS One
https://www.readbyqxmd.com/read/29044738/overview-of-mechanisms-of-antibiotic-resistance-in-pseudomonas-aeruginosa-an-ocular-perspective
#13
REVIEW
Dinesh Subedi, Ajay Kumar Vijay, Mark Willcox
Treatment of Pseudomonas aeruginosa eye infections often becomes a challenge due to the ability of this bacterium to be resistant to antibiotics via intrinsic and acquired mechanisms. Transfer of resistance due to interchangeable genetic elements is an important mechanism for the rapid transfer of antibiotic resistance in this pathogen. As a result, drug-resistant strains are becoming increasingly prevalent worldwide. This review systematically analyses data from recent publications to describe the global prevalence and antibiotic sensitivity of ocular P...
October 18, 2017: Clinical & Experimental Optometry: Journal of the Australian Optometrical Association
https://www.readbyqxmd.com/read/29044002/irrational-antibiotic-prescribing-practice-among-children-in-critical-care-of-tertiary-hospitals
#14
Mirza Tasawer Baig, Ali Akbar Sial, Ambreen Huma, Maryam Ahmed, Uzma Shahid, Nayel Syed
This study assessed the prescribing pattern of irrational use of antibiotic among children under age of 12 years in public and private sector hospitals in Pakistan. The prospective clinical evaluation of drug utilization pattern of antimicrobials from Patient Bedside File (PBF) of in-patients and Culture Sensitivity Test (CST) reports were evaluated to determine the antibiotic resistance. Two indicators recorded to assess antibiotic prescribing were; dose of prescribed antibiotic (low-dose, rational and high -dose) and Indication (valid or invalid)...
July 2017: Pakistan Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/29043494/influence-of-proline-substitution-on-the-bioactivity-of-mammalian-derived-antimicrobial-peptide-nk-2
#15
Jiexi Yan, Xiaolei Liang, Chang Liu, Yuemei Cheng, Lanxia Zhou, Kairong Wang, Li Zhao
Multidrug-resistant bacteria are emerging as a global threat, making the search for alternative compounds urgent. Antimicrobial peptides (AMPs) became a promising hotspot due to their distinct action mechanism and possibility to be used as an alternative or complement to traditional antibiotics. However, gaining a better understanding about the relationship between antimicrobial peptides structure and its bioactivity is crucial for the development of next generation of antimicrobial agents. NK-2, derived from mammalian protein NK-lysin, has potent antitumor and bactericidal abilities...
October 17, 2017: Probiotics and Antimicrobial Proteins
https://www.readbyqxmd.com/read/29042186/bacterial-biofilm-and-associated-infections
#16
REVIEW
Muhsin Jamal, Wisal Ahmad, Saadia Andleeb, Fazal Jalil, Muhammad Imran, Muhammad Asif Nawaz, Tahir Hussain, Muhammad Ali, Muhammad Rafiq, Muhammad Atif Kamil
Microscopic entities, microorganisms that drastically affect human health need to be thoroughly investigated. A biofilm is an architectural colony of microorganisms, within a matrix of extracellular polymeric substance that they produce. Biofilm contains microbial cells adherent to one-another and to a static surface (living or non-living). Bacterial biofilms are usually pathogenic in nature and can cause nosocomial infections. The National Institutes of Health (NIH) revealed that among all microbial and chronic infections, 65% and 80%, respectively, are associated with biofilm formation...
October 14, 2017: Journal of the Chinese Medical Association: JCMA
https://www.readbyqxmd.com/read/29040083/consumption-of-edible-ice-contaminated-with-acinetobacter-pseudomonas-and-stenotrophomonas-is-a-risk-factor-for-fecal-colonization-with-extended-spectrum-%C3%AE-lactamase-producing-escherichia-coli-in-vietnam
#17
Tatsuya Nakayama, Nguyen Cong Ha, Phong Quoc Le, Ryuji Kawahara, Yuko Kumeda, Yoshinori Sumimura, Yoshimasa Yamamoto
Although Vietnamese residents frequently harbor extended-spectrum β-lactamase-producing Escherichia coli (ESBL-E), it is unclear which foods/beverages are risk factors for acquiring these bacteria. The aim of this study was to evaluate the frequency with which edible ice served in restaurants is contaminated with antibiotic-resistant bacteria, and thereby clarify whether this product poses a risk for ESBL-E carriage in humans. Ice from restaurants in Vietnam and Japan was screened for bacteria capable of growing on agar containing cefotaxime (BG-CTX)...
2017: Journal of Water and Health
https://www.readbyqxmd.com/read/29039211/synergistic-effects-of-heat-and-antibiotics-on-pseudomonas-aeruginosa-biofilms
#18
Erica B Ricker, Eric Nuxoll
Upon formation of a biofilm, bacteria undergo several changes that prevent eradication with antimicrobials alone. Due to this resistance, the standard of care for infected medical implants is explantation of the infected implant and surrounding tissue, followed by eventual reimplantation of a replacement device. Recent studies have demonstrated the efficacy of heat shock for biofilm eradication. To minimize the heat required for in situ biofilm eradication, this study investigated the hypothesis that antibiotics, while ineffective by themselves, may substantially increase heat shock efficacy...
October 17, 2017: Biofouling
https://www.readbyqxmd.com/read/29038771/detection-of-antibiotic-resistance-genes-in-the-feces-of-young-adult-japanese
#19
Yuji Ohashi, Tomohiko Fujisawa
Antibiotic resistance genes in the feces of healthy young adult Japanese were analyzed with polymerase chain reaction using specific primers. Antibiotic resistance genes against macrolides (ermB, ermF, ermX, and mefA/E), tetracyclines (tetW, tetQ, tetO, and tetX), β-lactam antibiotics (blaTEM ), and streptomycin (aadE) were detected in more than 50% of subjects. These antibiotic resistance genes are likely widespread in the large intestinal bacteria of young adult Japanese.
2017: Bioscience of Microbiota, Food and Health
https://www.readbyqxmd.com/read/29038662/multidrug-resistant-enteric-bacterial-pathogens-in-a-psychiatric-hospital-in-ghana-implications-for-control-of-nosocomial-infections
#20
Kwabena O Duedu, George Offei, Francis S Codjoe, Eric S Donkor
Enteric bacteria are commonly implicated in hospital-acquired or nosocomial infections. In Ghana, these infections constitute an important public health problem but little is known about their contribution to antibiotic resistance. The aim of the study was to determine the extent and pattern of antibiotic resistance of enteric bacteria isolated from patients and environmental sources at the Accra Psychiatric Hospital. A total of 265 samples were collected from the study site including 142 stool and 82 urine samples from patients, 7 swab samples of door handle, and 3 samples of drinking water...
2017: International Journal of Microbiology
keyword
keyword
106942
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"