keyword
https://read.qxmd.com/read/38534649/the-impact-of-covid-19-on-multidrug-resistant-bacteria-at-a-slovenian-tertiary-medical-center
#21
JOURNAL ARTICLE
Tatjana Mrvič, Sintija Stevanoska, Bojana Beović, Mateja Logar, Sergeja Gregorčič, Benica Žnidaršič, Katja Seme, Ivana Velimirović, Nataša Švent Kučina, Polona Maver Vodičar, Veronika Križan Hergouth, Sašo Džeroski, Mateja Pirs
The COVID-19 pandemic has strained healthcare systems globally. Shortages of hospital beds, reassignment of healthcare workers to COVID-19-dedicated wards, an increased workload, and evolving infection prevention and control measures have potentially contributed to the spread of multidrug-resistant bacteria (MDRB). To determine the impact of the COVID-19 pandemic at the University Medical Center Ljubljana, a tertiary teaching hospital, we analyzed the monthly incidence of select bacterial species per patient from 2018 to 2022...
February 23, 2024: Antibiotics
https://read.qxmd.com/read/38534640/control-of-escherichia-coli-in-poultry-using-the-in-ovo-injection-technique
#22
REVIEW
Gabriel da Silva Oliveira, Concepta McManus, Vinícius Machado Dos Santos
Pathogens, such as Escherichia coli ( E . coli ), have been identified as significant causes of poultry mortality. Poultry can serve as potential sources of E . coli transmission, even when asymptomatic, posing a substantial threat to food safety and human health. The in ovo administration of antimicrobials is crucial for preventing and/or effectively combating acute and chronic infections caused by poultry pathogens. To achieve this goal, it is critical that antimicrobials are properly injected into embryonic fluids, such as the amnion, to reach target tissues and trigger robust antimicrobial responses...
February 22, 2024: Antibiotics
https://read.qxmd.com/read/38534635/synergistic-activity-of-ingulados-bacteria-with-antibiotics-against-multidrug-resistant-pathogens
#23
JOURNAL ARTICLE
Javier Blanco-Blanco, María Bravo, Irene Simón, Pedro Fernández-Llario, Miguel Fajardo-Olivares, María Coronada Fernández-Calderón, Rosario Cerrato
Antimicrobial resistance is a critical challenge due to the overuse of conventional antimicrobials, and alternative solutions are urgently needed. This study investigates the efficacy of compounds derived from lactic acid bacteria (LAB) fermentation combined with antibiotics against multidrug-resistant pathogens isolated from clinical cases in a hospital setting. Strains of Escherichia coli , Klebsiella pneumoniae , and Enterococcus faecium and faecalis were isolated and selected from blood, respiratory, and urine samples...
February 20, 2024: Antibiotics
https://read.qxmd.com/read/38534122/antibiotic-resistance-begets-more-resistance-chromosomal-resistance-mutations-mitigate-fitness-costs-conferred-by-multi-resistant-clinical-plasmids
#24
JOURNAL ARTICLE
Ramith R Nair, Dan I Andersson, Omar M Warsi
Plasmids are the primary vectors of horizontal transfer of antibiotic resistance genes among bacteria. Previous studies have shown that the spread and maintenance of plasmids among bacterial populations depend on the genetic makeup of both the plasmid and the host bacterium. Antibiotic resistance can also be acquired through mutations in the bacterial chromosome, which not only confer resistance but also result in changes in bacterial physiology and typically a reduction in fitness. However, it is unclear whether chromosomal resistance mutations affect the interaction between plasmids and the host bacteria...
March 27, 2024: Microbiology Spectrum
https://read.qxmd.com/read/38534100/plant-phenolics-inhibit-focal-adhesion-kinase-and-suppress-host-cell-invasion-by-uropathogenic-escherichia-coli
#25
JOURNAL ARTICLE
Adam J Lewis, Amanda C Richards, Alejandra A Mendez, Bijaya K Dhakal, Tiffani A Jones, Jamie L Sundsbak, Danelle S Eto, Alexis A Rousek, Matthew A Mulvey
Traditional folk treatments for the prevention and management of urinary tract infections (UTIs) and other infectious diseases often include plants and plant extracts that are rich in phenolic compounds. These have been ascribed a variety of activities, including inhibition of bacterial interactions with host cells. Here, we tested a panel of four well-studied phenolic compounds-caffeic acid phenethyl ester (CAPE), resveratrol, catechin, and epigallocatechin gallate-for the effects on host cell adherence and invasion by uropathogenic Escherichia coli (UPEC)...
March 27, 2024: Infection and Immunity
https://read.qxmd.com/read/38532711/infection-microenvironment-responsive-coating-on-titanium-surfaces-for-on-demand-release-of-therapeutic-gas-and-antibiotic
#26
JOURNAL ARTICLE
Kun Wang, Fan Rong, Haowei Peng, Zhang Yuan, Jingjing Huo, Pengxiang Liu, Rui Ding, Cuiping Yan, Guming Liu, Tengjiao Wang, Peng Li
Aseptic loosening and bacterial infection pose significant challenges in the clinical application of titanium (Ti) orthopedic implants, which are primarily caused by insufficient osseointegration and bacterial contamination. To address these issues, we constructed a responsive coating on Ti surface, which achieved enhanced osseointegration and infection elimination by on-demand release of therapeutic gas hydrogen sulfide (H2 S) and antibiotic. TiO2 nanotubes (TNT) were anodized on the Ti surface to enhance its bioactivity and serve as reservoirs for the antibiotic...
March 27, 2024: Advanced Healthcare Materials
https://read.qxmd.com/read/38532068/a-comprehensive-computational-study-to-explore-promising-natural-bioactive-compounds-targeting-glycosyltransferase-murg-in-escherichia-coli-for-potential-drug-development
#27
JOURNAL ARTICLE
Amneh Shtaiwi, Shafi Ullah Khan, Meriem Khedraoui, Mohd Alaraj, Abdelouahid Samadi, Samir Chtita
Peptidoglycan is a carbohydrate with a cross-linked structure that protects the cytoplasmic membrane of bacterial cells from damage. The mechanism of peptidoglycan biosynthesis involves the main synthesizing enzyme glycosyltransferase MurG, which is known as a potential target for antibiotic therapy. Many MurG inhibitors have been recognized as MurG targets, but high toxicity and drug-resistant Escherichia coli strains remain the most important problems for further development. In addition, the discovery of selective MurG inhibitors has been limited to the synthesis of peptidoglycan-mimicking compounds...
March 26, 2024: Scientific Reports
https://read.qxmd.com/read/38531534/comprehensive-assessment-of-risk-factors-and-pathogenic-characteristics-of-wound-infections-following-thoracoscopic-radical-resection-for-lung-cancer
#28
JOURNAL ARTICLE
Jian Xu, Jianhua Zhu
Lung cancer remains a leading cause of cancer-related mortality, with surgical resection as a primary treatment modality. However, postoperative wound infections (PWIs) pose significant risks following thoracoscopic radical resection. This study aims to identify the risk factors and pathogenetic characteristics associated with PWIs in lung cancer surgery. A comprehensive retrospective study was conducted from August 2021 to June 2023 at our institution. The study included 30 patients who developed PWIs and 60 controls who did not, following thoracoscopic radical resection for lung cancer...
April 2024: International Wound Journal
https://read.qxmd.com/read/38530961/green-synthesis-of-metal-doped-zno-nanoparticles-using-bauhinia-racemosa-lam-extract-and-evaluation-of-their-photocatalysis-and-biomedical-applications
#29
JOURNAL ARTICLE
Anusuya Mariappan, Leelavathi Harikrishnan, Jayanthi Eswaran, Nagaveni Arumugham, Yogeswari Balasubramaniam, Santhanaraj Daniel, Rajakumar Kanthapazham
A fascinating problem in the fields of nanoscience and nanobiotechnology has recently emerged, and to tackle this, the production of metal oxide nanoparticles using plant extracts offers numerous benefits over traditional physicochemical methods. In the present investigation, ZnO nanoparticles were fabricated from Bauhinia racemosa Lam. (BR) leaves extract with various transition metal (TM) dopants (Ni, Mn, and Co). Plant leaves extract containing metal nitrate solutions were utilized as a precursor to synthesize the pristine and TM-doped ZnO nanoparticles...
March 26, 2024: ACS Applied Bio Materials
https://read.qxmd.com/read/38530058/characterization-of-clumpy-adhesion-of-escherichia-coli-to-human-cells-and-associated-factors-influencing-antibiotic-sensitivity
#30
JOURNAL ARTICLE
Muhammad Moman Khan, Katarzyna Sidorczuk, Juliane Becker, Adrianna Aleksandrowicz, Karolina Baraniewicz, Christina Ludwig, Aamir Ali, Robert A Kingsley, Peter Schierack, Rafał Kolenda
UNLABELLED: Escherichia coli intestinal infection pathotypes are characterized by distinct adhesion patterns, including the recently described clumpy adhesion phenotype. Here, we identify and characterize the genetic factors contributing to the clumpy adhesion of E. coli strain 4972. In this strain, the transcriptome and proteome of adhered bacteria were found to be distinct from planktonic bacteria in the supernatant. A total of 622 genes in the transcriptome were differentially expressed in bacteria present in clumps relative to the planktonic bacteria...
March 26, 2024: Microbiology Spectrum
https://read.qxmd.com/read/38528800/rapid-phenotypic-antibiotics-susceptibility-analysis-by-a-3d-printed-prototype
#31
JOURNAL ARTICLE
Oliver Riester, Lars Kaiser, Stefan Laufer, Hans-Peter Deigner
One of the most important public health concerns is the increase in antibiotic-resistant pathogens and corresponding treatment of associated infections. Addressing this challenge requires more efficient use of antibiotics, achievable by the use of evidence-based, effective antibiotics identified by antibiotic susceptibility testing (AST). However, the current standard method of phenotypic AST used for this purpose requires 48 h or more from sample collection to result. Until results are available, broad-spectrum antibiotics are used to avoid delaying treatment...
March 26, 2024: Advanced Science (Weinheim, Baden-Wurttemberg, Germany)
https://read.qxmd.com/read/38527976/identification-of-non-canonical-antagonistic-bacteria-via-interspecies-contact-dependent-killing
#32
JOURNAL ARTICLE
Long Lin, Min Tao, Wei-Mei He, Qian-Hua Wu, Hao-Kai Huang, Aprodisia Kavutu Murero, Xiao-Long Shao, Li-Min Wang, Guo-Liang Qian
BACKGROUND: Canonical biocontrol bacteria were considered to inhibit pathogenic bacteria mainly by secreting antibiotic metabolites or enzymes. Recent studies revealed that some biocontrol bacteria can inhibit pathogenic bacteria through contact-dependent killing (CDK) mediated by contact-dependent secretion systems. The CDK was independent of antibiotic metabolites and often ignored in normal biocontrol activity assay. RESULTS: In this study, we aimed to use a pathogen enrichment strategy to isolate non-canonical bacteria with CDK ability...
March 25, 2024: Pest Management Science
https://read.qxmd.com/read/38527924/photopolymerizable-and-antibacterial-hydrogels-loaded-with-metabolites-from-lacticaseibacillus-rhamnosus-gg-for-infected-wound-healing
#33
JOURNAL ARTICLE
Yanting Han, Zhe Yin, Yilin Wang, Yuanzhang Jiang, Jianming Chen, Zhonghua Miao, Fang He, Ruyue Cheng, Lin Tan, Ka Li
In response to increasing antibiotic resistance and the pressing demand for safer infected wound care, probiotics have emerged as promising bioactive agents. To address the challenges associated with the safe and efficient application of probiotics, this study successfully loaded metabolites from Lacticaseibacillus rhamnosus GG (LGG) into a gelatin cross-linked macromolecular network by an in situ blending and photopolymerization method. The obtained LM-GelMA possesses injectability and autonomous healing capabilities...
March 25, 2024: Biomacromolecules
https://read.qxmd.com/read/38527612/epidemiology-of-escherichia-coli-bloodstream-infection-antimicrobial-resistance-trends-across-south-west-england-during-the-first-two-years-of-the-coronavirus-disease-2019-pandemic-response
#34
JOURNAL ARTICLE
J Stanley, B Sullivan, A W Dowsey, K Jones, C R Beck
OBJECTIVES: Between 2016-19, the proportion of Escherichia coli bloodstream infection (BSI) with resistance to at least one antibiotic increased nationally. Public health interventions implemented in response to the coronavirus disease 2019 (COVID-19) pandemic changed population contact patterns and healthcare systems, with consequent effects on epidemiological trends of numerous pathogens. We investigated the impact of COVID-19 restrictions on epidemiological trends of E. coli BSI antimicrobial resistance (AMR) across South West England...
March 23, 2024: Clinical Microbiology and Infection
https://read.qxmd.com/read/38527537/connectivity-at-the-human-wildlife-interface-starling-movements-relate-to-carriage-of-e-coli
#35
JOURNAL ARTICLE
Alberto Sánchez-Cano, Cosme López-Calderón, Teresa Cardona Cabrera, Andy J Green, Ursula Höfle
Synanthropic bird species in human, poultry or livestock environments can increase the spread of pathogens and antibiotic-resistant bacteria between wild and domestic animals. We present the first telemetry-based spatial networks for a small songbird. We quantified landscape connectivity exerted by spotless starling movements, and aimed to determine if connectivity patterns were related to carriage of potential pathogens. We captured 28 starlings on a partridge farm in 2020 and tested them for Avian influenza virus, West Nile virus WNV, Avian orthoavulavirus 1, Coronavirus, Salmonella spp...
March 23, 2024: Science of the Total Environment
https://read.qxmd.com/read/38526818/therapeutic-effects-of-orally-administration-of-viable-and-inactivated-probiotic-strains-against-murine-urinary-tract-infection
#36
REVIEW
Vo Thi Hong Van, Zhen-Shu Liu, Yueh-Jen Hsieh, Wei-Chen Shiu, Bo-Yuan Chen, Yu-We Ku, Po-Wen Chen
Urinary tract infections (UTIs) are highly prevalent bacterial infections that pose significant health risks. Specific probiotic strains have been recommended for UTI control and management of antibiotic resistance. Otherwise, para-probiotics, defined as inactivated probiotic cells, offer potential advantages by minimizing risks associated with live microorganisms. However, the effectiveness of heat-killed probiotic strains against UTIs remains uncertain. Additionally, lactoferrin (LF), an iron-binding glycoprotein, exhibits immunomodulatory, antimicrobial, and anti-inflammatory properties...
December 15, 2023: Journal of Food and Drug Analysis
https://read.qxmd.com/read/38526080/infection-and-antibiotic-associated-changes-in-the-fecal-microbiota-of-c-rodentium-%C3%AF-stx2-dact-infected-c57bl-6-mice
#37
JOURNAL ARTICLE
Sabrina Mühlen, Ann Kathrin Heroven, Bettina Elxnat, Silke Kahl, Dietmar H Pieper, Petra Dersch
Enterohemorrhagic Escherichia coli causes watery to bloody diarrhea, which may progress to hemorrhagic colitis and hemolytic-uremic syndrome. While early studies suggested that antibiotic treatment may worsen the pathology of an enterohemorrhagic Escherichia coli (EHEC) infection, recent work has shown that certain non-Shiga toxin-inducing antibiotics avert disease progression. Unfortunately, both intestinal bacterial infections and antibiotic treatment are associated with dysbiosis. This can alleviate colonization resistance, facilitate secondary infections, and potentially lead to more severe illness...
March 25, 2024: Antimicrobial Agents and Chemotherapy
https://read.qxmd.com/read/38524454/bioinspired-stevia-rebaudiana-green-zinc-oxide-nanoparticles-for-the-adsorptive-removal-of-antibiotics-from-water
#38
JOURNAL ARTICLE
Hania A Guirguis, Noha Youssef, Mariam William, Dania Abdel-Dayem, Mayyada M H El-Sayed
Green zinc oxide nanoparticles (ZnO NPs) synthesized using Stevia rebaudiana as a reducing agent were investigated as ecofriendly adsorbents for the removal of the antibiotics ciprofloxacin (CIP) and tetracycline (TET) from water. Green ZnO NPs were synthesized using a rapid novel approach that did not require annealing or calcination at high temperatures to produce mesoporous NPs with a size range of 37.36-71.33 nm, a specific surface area of 15.28 m2 /g, and a negative surface charge of -15 mV at pH 5. The green ZnO NPs exhibited an antioxidant activity of 85...
March 19, 2024: ACS Omega
https://read.qxmd.com/read/38523919/local-antimicrobial-resistance-trends-in-pediatric-urinary-tract-infection-the-importance-of-local-surveillance-of-a-global-problem
#39
JOURNAL ARTICLE
Andreia Fernandes, Íris Oliveira, Mafalda Pereira, Patricia Mendes, Maria João Virtuoso, Alejandra Pereira
Introduction Urinary tract infections (UTIs) are one of the most common pediatric bacterial infections and consequently a major reason for antibiotic treatment. Despite being a global problem, antimicrobial resistance is often geographically heterogeneous. Thus, it is fundamental to know local epidemiology and practice frequent surveillance of each hospital's antibiograms. The aims of this study are to determine the local antimicrobial resistance profile in pediatric UTIs, to understand its evolution over 14 years, and finally, to infer if the currently instituted antibiotic empirical therapy remains effective...
February 2024: Curēus
https://read.qxmd.com/read/38522537/integrating-metagenomic-and-isolation-strategies-revealed-high-contamination-of-pathogenies-and-resistome-in-market-shrimps
#40
JOURNAL ARTICLE
Lianwei Ye, Zhiwei Zheng, Yaling Wang, Qiao Hu, Liang Zhong, Heng Heng, Zhihao Guo, Runsheng Li, Edward Wai Chi Chan, Sheng Chen
This study employs a comprehensive approach combining metagenomic analysis and bacterial isolation to elucidate the microbial composition, antibiotic resistance genes (ARGs), and virulence factors (VFGs) present in shrimps from market and supermarket. Metagenomic analysis of shrimps revealed a dominance of Proteobacteria and Bacteroidetes with Firmicutes notably enriched in some samples. On the other hand, the dominant bacteria isolated included Citrobacter portucalensis, Escherichia coli, Salmonella enterica, Vibrio species and Klebsiella pneumonaie...
March 22, 2024: Science of the Total Environment
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