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Antibiotics for escherichia coli

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https://www.readbyqxmd.com/read/29145163/spread-of-multidrug-resistant-escherichia-coli-harboring-integron-via-swine-farm-waste-water-treatment-plant
#1
Jin-Hyeong Park, Young-Ji Kim, Binn-Kim, Kun-Ho Seo
Wastewater treatment plants (WWTPs) that release treated wastewater into the environment have emerged as a major threat to public health. In this study, we investigated Escherichia coli load and antibiotic-resistance profiles across different treatment processes at a swine farm WWTP. The frequency of the detection of class 1 and 2 integrons, and their association with antibiotic resistance, were also analyzed. Samples were obtained at each of five sampling sites that represented each processing step within the WWTP...
November 13, 2017: Ecotoxicology and Environmental Safety
https://www.readbyqxmd.com/read/29143727/characterization-of-clinically-isolated-thymidine-dependent-small-colony-variants-of-escherichia-coli-producing-extended-spectrum-%C3%AE-lactamase
#2
Tatsuya Negishi, Takehisa Matsumoto, Kazuki Horiuchi, Eriko Kasuga, Tatsuya Natori, Mina Matsuoka, Naoko Ogiwara, Mitsutoshi Sugano, Takeshi Uehara, Noriyuki Nagano, Takayuki Honda
PURPOSE: Thymidine-dependent small-colony variants (TD-SCVs) are difficult to detect or test for antimicrobial susceptibility. We investigated the characteristics of clonal TD-SCVs of Escherichia coli, both with and without blaCTX-M-3, isolated from a patient. METHODOLOGY: Mutation in the thyA gene was analysed by sequencing, and morphological abnormalities in the colonies and cells of the isolates were examined. Additionally, conjugational transfer experiments were performed to prove the horizontal transferability of plasmids harbouring resistance genes...
November 16, 2017: Journal of Medical Microbiology
https://www.readbyqxmd.com/read/29142389/bioactive-constituents-radical-scavenging-and-antibacterial-properties-of-the-leaves-and-stem-essential-oils-from-peperomia-pellucida-l-kunth
#3
Sunday O Okoh, Benson C Iweriebor, Omobola O Okoh, Anthony I Okoh
Background: Peperomia pellucida is an annual herbaceous ethnomedicinal plant used in the treatment of a variety of communicable and noncommunicable diseases in the Amazon region. Objective: The study aimed at profiling the bioactive constituents of the leaves and stem essential oils (LEO and SEO) of P. pellucida, their in vitro antibacterial and radical scavenging properties as probable lead constituents in the management of oxidative stress and infectious diseases...
October 2017: Pharmacognosy Magazine
https://www.readbyqxmd.com/read/29142299/the-immunomodulatory-drug-glatiramer-acetate-is-also-an-effective-antimicrobial-agent-that-kills-gram-negative-bacteria
#4
Stig Hill Christiansen, Ronan A Murphy, Kristian Juul-Madsen, Marlene Fredborg, Michael Lykke Hvam, Esben Axelgaard, Sandra M Skovdal, Rikke Louise Meyer, Uffe B Skov Sørensen, Arne Möller, Jens Randel Nyengaard, Niels Nørskov-Lauritsen, Mikala Wang, Mihaela Gadjeva, Kenneth A Howard, Jane C Davies, Eskild Petersen, Thomas Vorup-Jensen
Classic drug development strategies have failed to meet the urgent clinical needs in treating infections with Gram-negative bacteria. Repurposing drugs can lead to timely availability of new antibiotics, accelerated by existing safety profiles. Glatiramer acetate (GA) is a widely used and safe formulation for treatment of multiple sclerosis. It contains a large diversity of essentially isomeric polypeptides with the cationic and amphiphilic character of many antimicrobial peptides (AMP). Here, we report that GA is antibacterial, targeting Gram-negative organisms with higher activity towards Pseudomonas aeruginosa than the naturally-occurring AMP LL-37 in human plasma...
November 15, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29142298/shaping-bacterial-population-behavior-through-computer-interfaced-control-of-individual-cells
#5
Remy Chait, Jakob Ruess, Tobias Bergmiller, Gašper Tkačik, Călin C Guet
Bacteria in groups vary individually, and interact with other bacteria and the environment to produce population-level patterns of gene expression. Investigating such behavior in detail requires measuring and controlling populations at the single-cell level alongside precisely specified interactions and environmental characteristics. Here we present an automated, programmable platform that combines image-based gene expression and growth measurements with on-line optogenetic expression control for hundreds of individual Escherichia coli cells over days, in a dynamically adjustable environment...
November 16, 2017: Nature Communications
https://www.readbyqxmd.com/read/29141885/a-role-for-bacterial-urease-in-gut-dysbiosis-and-crohn-s-disease
#6
Josephine Ni, Ting-Chin David Shen, Eric Z Chen, Kyle Bittinger, Aubrey Bailey, Manuela Roggiani, Alexandra Sirota-Madi, Elliot S Friedman, Lillian Chau, Andrew Lin, Ilana Nissim, Justin Scott, Abigail Lauder, Christopher Hoffmann, Gloriany Rivas, Lindsey Albenberg, Robert N Baldassano, Jonathan Braun, Ramnik J Xavier, Clary B Clish, Marc Yudkoff, Hongzhe Li, Mark Goulian, Frederic D Bushman, James D Lewis, Gary D Wu
Gut dysbiosis during inflammatory bowel disease involves alterations in the gut microbiota associated with inflammation of the host gut. We used a combination of shotgun metagenomic sequencing and metabolomics to analyze fecal samples from pediatric patients with Crohn's disease and found an association between disease severity, gut dysbiosis, and bacterial production of free amino acids. Nitrogen flux studies using (15)N in mice showed that activity of bacterial urease, an enzyme that releases ammonia by hydrolysis of host urea, led to the transfer of murine host-derived nitrogen to the gut microbiota where it was used for amino acid synthesis...
November 15, 2017: Science Translational Medicine
https://www.readbyqxmd.com/read/29139345/herbicide-ingredients-change-salmonella-enterica-sv-typhimurium-and-escherichia-coli-antibiotic-responses
#7
Brigitta Kurenbach, Paddy S Gibson, Amy M Hill, Adam S Bitzer, Mark W Silby, William Godsoe, Jack A Heinemann
Herbicides are frequently released into both rural and urban environments. Commercial herbicide formulations induce adaptive changes in the way bacteria respond to antibiotics. Salmonella enterica sv. Typhimurium and Escherichia coli were exposed to common co-formulants of formulations, and S. enterica sv. Typhimurium was exposed to active ingredients dicamba, 2,4-D and glyphosate to determine what ingredients of the commercial formulations caused this effect. Co-formulants Tween80 and carboxymethyl cellulose induced changes in response, but the pattern of the responses differed from the active ingredients, and effect sizes were smaller...
November 17, 2017: Microbiology
https://www.readbyqxmd.com/read/29138665/-epidemiological-profile-of-uropathogenic-enterobacteria-producing-extended-spectrum-beta-lactamases
#8
Mohammed Sbiti, Khalid Lahmadi, Lhoussaine Louzi
Urinary tract infections due to enterobacteria producing extended spectrum beta-lactamases (ESBL-E) constitute a infectious risk, a major therapeutic challenge and can even lead, in some cases, to a deadlock beacuse of their multi-resistance to antibiotics. This study aimed to determine the epidemiological profile of uropathogenic ESBL-E and to describe their current level of resistance to antibiotics for a better patient management according to local data. We conducted a retrospective study of all ESBL-E strains isolated from all cytobacteriogical testing of urine (CBEU) treated in the Microbiology Laboratory at the Military Hospital of Moulay Ismail, Meknes over a period of three years (from 1 January 2013 to 31 December 2015)...
2017: Pan African Medical Journal
https://www.readbyqxmd.com/read/29138582/once-daily-intramuscular-amikacin-for-outpatient-treatment-of-lower-urinary-tract-infections-caused-by-extended-spectrum-%C3%AE-lactamase-producing-escherichia-coli-in-children
#9
Meltem Polat, Soner Sertan Kara
Background: The rise in community-acquired urinary tract infections (UTIs) with extended-spectrum β-lactamase (ESBL)-producing Escherichia coli strains raises the question of how to treat these infections effectively in pediatric outpatients. Amikacin has shown promising in vitro activity against ESBL-producing urinary isolates of E. coli; however, clinical data are limited. Objective: To investigate the clinical and microbiological outcomes of community-acquired lower UTIs caused by ESBL-producing E...
2017: Infection and Drug Resistance
https://www.readbyqxmd.com/read/29138562/dual-uv-irradiation-based-metal-oxide-nanoparticles-for-enhanced-antimicrobial-activity-in-escherichia-coli-and-m13-bacteriophage
#10
Su-Eon Jin, Woochul Hwang, Hyo Jung Lee, Hyo-Eon Jin
Metal oxide (MO) nanoparticles have been studied as nano-antibiotics due to their antimicrobial activities even in antibiotic-resistant microorganisms. We hypothesized that a hybrid system of dual UV irradiation and MO nanoparticles would have enhanced antimicrobial activities compared with UV or MO nanoparticles alone. In this study, nanoparticles of ZnO, ZnTiO3, MgO, and CuO were selected as model nanoparticles. A dual UV collimated beam device of UV-A and UV-C was developed depending upon the lamp divided by coating...
2017: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/29137595/study-of-bacterial-infections-among-patients-receiving-kidney-transplant-in-mashhad-iran
#11
Davood Mansury, Azad Khaledi, Kiarash Ghazvini, Mahin Ghorban Sabbagh, Hosna Zare, Mohammad Hossein Rokni-Hosseini, Hossein Vazini
OBJECTIVES: Over the past 2 decades, significant advances have been made in the management of infections after transplant; however, transplant recipients are still at high risk of infectious complications. This study aimed to evaluate the prevalence of bacterial infections and antimicrobial resistance patterns in kidney transplant recipients. MATERIALS AND METHODS: This cross-sectional study included 356 patients who received kidney transplants, regardless of the underlying disease, from 2013 to 2015 at the Montaserieh Transplant Hospital (Mashhad, Iran)...
November 15, 2017: Experimental and Clinical Transplantation
https://www.readbyqxmd.com/read/29136922/immunosensing-system-for-rapid-multiplex-detection-of-mastitis-causing-pathogens-in-milk
#12
Delia Juronen, Ave Kuusk, Kairi Kivirand, Ago Rinken, Toonika Rinken
Mastitis, an inflammation of the mammary gland and udder tissue, is the major endemic disease of dairy cattle. In addition to causing health problems to the animals, mastitis leads to the reduction of milk production and quality, representing a significant economic burden for farmers. To enable timely treatment of infected animals with pathogen-specific antibiotics, the development of automated analytical methods for rapid on-site identification and quantification of mastitis-causing pathogens in milk is particularly important...
February 1, 2018: Talanta
https://www.readbyqxmd.com/read/29136882/growth-of-escherichia-coli-on-the-gaas-001-surface
#13
Elnaz Nazemi, Walid M Hassen, Eric H Frost, Jan J Dubowski
Detection of pathogenic bacteria and monitoring their susceptibility to antibiotics are of great importance in the fields of medicine, pharmaceutical research, as well as water and food industries. In order to develop a photonic biosensor for detection of bacteria by taking advantage of photoluminescence (PL) of GaAs-based devices, we have investigated the capture and growth of Escherichia coli K12 on bare and biofunctionalized surfaces of GaAs (001) - a material of interest for capping different semiconductor microstructures...
February 1, 2018: Talanta
https://www.readbyqxmd.com/read/29136373/photocontrol-of-antibacterial-activity-shifting-from-uv-to-red-light-activation
#14
Michael Wegener, Mickel J Hansen, Arnold J M Driessen, Wiktor Szymanski, Ben L Feringa
The field of photopharmacology aims to introduce smart drugs that, through the incorporation of molecular photoswitches, allow for the remote spatial and temporal control of bioactivity by light. This concept could be particularly beneficial in the treatment of bacterial infections, by reducing the systemic and environmental side-effects of antibiotics. A major concern in the realization of such light-responsive drugs is the wavelength of the light that is applied. Studies on the photocontrol of biologically active agents mostly rely on UV light, which is cytotoxic and poorly suited for tissue penetration...
November 14, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/29135241/the-antibiotic-novobiocin-binds-and-activates-the-atpase-that-powers-lipopolysaccharide-transport
#15
Janine M May, Tristan Wold Owens, Michael Dan Mandler, Brent W Simpson, Michael Lazarus, David J Sherman, Rebecca M Davis, Suguru Okuda, Walter Massefski, Natividad Ruiz, Daniel Kahne
Most natural product antibiotics are well known for one mecha-nism of action. Novobiocin is an orally active antibiotic that in-hibits DNA gyrase by binding the ATP-binding site in the ATPase subunit. Although effective against Gram-positive pathogens, novobiocin has limited activity against Gram-negative organisms due to the presence of the lipopolysaccharide-containing outer membrane, which acts as a permeability barrier. Using a novobi-ocin-sensitive Escherichia coli strain with a leaky outer membrane, we identified a mutant with increased resistance to novobiocin...
November 14, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/29134588/encapsulation-strategies-of-bacteriophage-felix-o1-for-oral-therapeutic-application
#16
Golam S Islam, Qi Wang, Parviz M Sabour
Due to emerging antibiotic-resistant strains among the pathogens, a variety of strategies, including therapeutic application of bacteriophages, have been suggested as a possible alternative to antibiotics in food animal production. As pathogen-specific biocontrol agents, bacteriophages are being studied intensively. Primarily their applications in the food industry and animal production have been recognized in the USA and Europe, for pathogens including Salmonella, Campylobacter, Escherichia coli, and Listeria...
2018: Methods in Molecular Biology
https://www.readbyqxmd.com/read/29133912/the-multiple-antibiotic-resistance-operon-of-enteric-bacteria-controls-dna-repair-and-outer-membrane-integrity
#17
Prateek Sharma, James R J Haycocks, Alistair D Middlemiss, Rachel A Kettles, Laura E Sellars, Vito Ricci, Laura J V Piddock, David C Grainger
The multiple antibiotic resistance (mar) operon of Escherichia coli is a paradigm for chromosomally encoded antibiotic resistance in enteric bacteria. The locus is recognised for its ability to modulate efflux pump and porin expression via two encoded transcription factors, MarR and MarA. Here we map binding of these regulators across the E. coli genome and identify an extensive mar regulon. Most notably, MarA activates expression of genes required for DNA repair and lipid trafficking. Consequently, the mar locus reduces quinolone-induced DNA damage and the ability of tetracyclines to traverse the outer membrane...
November 13, 2017: Nature Communications
https://www.readbyqxmd.com/read/29133052/design-and-synthesis-of-short-amphiphilic-cationic-peptidomimetics-based-on-biphenyl-backbone-as-antibacterial-agents
#18
Rajesh Kuppusamy, Muhammad Yasir, Thomas Berry, Charles G Cranfield, Shashidhar Nizalapur, Eugene Yee, Onder Kimyon, Aditi Taunk, Kitty K K Ho, Bruce Cornell, Mike Manefield, Mark Willcox, David StC Black, Naresh Kumar
Antimicrobial peptides (AMPs) and their synthetic mimics have received recent interest as new alternatives to traditional antibiotics in attempts to overcome the rise of antibiotic resistance in many microbes. AMPs are part of the natural defenses of most living organisms and they also have a unique mechanism of action against bacteria. Herein, a new series of short amphiphilic cationic peptidomimetics were synthesized by incorporating the 3'-amino-[1,1'-biphenyl]-3-carboxylic acid backbone to mimic the essential properties of natural AMPs...
November 10, 2017: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/29130778/lack-of-induced-mutagenesis-in-e-coli-or-human-lymphoblast-cell-line-upon-long-term-sub-culturing-in-medium-from-irradiated-meat
#19
Sachin N Hajare, Jyoti Tripathi, Satyendra Gautam
PURPOSE: Current study was aimed to enhance the confidence of consumers as well as entrepreneurs towards food irradiation program. MATERIALS AND METHODS: In this work, safety of high dose (25 kGy) irradiated meat samples (HDIMS) was ascertained by scoring mutation frequency through a long-term sub-culturing study in Escherichia coli MG1655 cells (ATCC 700926) up to 1500 generations (at 1%), 250 generations (at 5 and 10%) and human lymphoblast thymidine kinase heterozygote (TK6) cell line (ATCC CRL-8015) [at two gene loci, tk(-/+) (thymidine kinase) and hprt(+) (Hypoxanthine Phosphoribosyltransferase)] up to 156 generations using goat meat sample...
November 13, 2017: International Journal of Radiation Biology
https://www.readbyqxmd.com/read/29127049/predicting-mutant-selection-in-competition-experiments-with-ciprofloxacin-exposed-escherichia-coli
#20
David D Khan, Pernilla Lagerbäck, Christer Malmberg, Anders N Kristoffersson, Erik Gullberg, Cao Sha, Otto Cars, Dan I Andersson, Diarmaid Hughes, Elisabet I Nielsen, Lena E Friberg
Predicting competition between antibiotic susceptible wild-type and less susceptible mutant bacteria is valuable for understanding how drug concentrations influence emergence of resistance. Pharmacokinetic-pharmacodynamic (PKPD) models predicting the rate and extent of takeover of resistant bacteria during different antibiotic pressures can thereby be a valuable tool in improving treatment regimens. The aim of this study was to evaluate a previously developed mechanism-based PKPD model for its ability to predict in vitro mixed-population experiments with competition between E...
November 7, 2017: International Journal of Antimicrobial Agents
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