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Antibiotics for escherichia coli

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https://www.readbyqxmd.com/read/28453633/role-of-dna-gyrase-and-topoisomerase-iv-mutations-in-fluoroquinolone-resistance-of-capnocytophaga-spp-clinical-isolates-and-laboratory-mutants
#1
Elodie Ehrmann, Anne Jolivet-Gougeon, Martine Bonnaure-Mallet, Thierry Fosse
Objectives: Capnocytophaga spp. are often reported to cause bacteraemia and extra-oral infections and are characterized by their significant contribution to resistance to β-lactam and macrolide-lincosamide-streptogramin antibiotics in the human oral microbiota. The implication of mutations in the quinolone resistance-determining region (QRDR) of DNA gyrase A and B ( gyrA and gyrB ) and topoisomerase IV ( parC and parE ) of fluoroquinolone (FQ)-resistant Capnocytophaga spp., hitherto unknown, was explored in this study...
April 26, 2017: Journal of Antimicrobial Chemotherapy
https://www.readbyqxmd.com/read/28449019/the-clear-and-present-danger-of-carbapenemase-producing-enterobacteriaceae-cpe-in-new-zealand-time-for-a-national-response-plan
#2
Matthew Blakiston, Helen Heffernan, Sally Roberts, Joshua Freeman
Antimicrobial resistance (AMR) in general poses a threat to the sustainability of modern healthcare, but a particularly urgent and serious threat is posed by a specific group of antibiotic-resistant bacteria known as carbapenemase-producing Enterobacteriaceae (CPE). CPE are resistant to nearly all antibiotics and include common pathogens such as Escherichia coli and Klebsiella pneumoniae. In New Zealand, the incidence of CPE has increased from three isolates in 2012 to 45 in 2016. The current epidemiology of CPE in New Zealand has similarities with the extended-spectrum β-lactamase-producing Enterobacteriaceae (ESBL-PE) epidemic in the early 2000s (just before ESBL-PE underwent a non-linear increase in incidence)...
April 28, 2017: New Zealand Medical Journal
https://www.readbyqxmd.com/read/28448954/copper-complexes-containing-thiosemicarbazones-derived-from-6-nitropiperonal-antimicrobial-and-biophysical-properties
#3
Floyd A Beckford, Kelsey R Webb
A series of four thiosemicarbazones from 6-nitropiperonal along with the corresponding copper complexes were synthesized. The biophysical characteristics of the complexes were investigated by the binding to DNA and human serum albumin. The binding to DNA is moderate; the binding constants run from (0.49-7.50)×10(4)M(-1). In relation to HSA, the complexes interact strongly with binding constants on the order of 10(5)M(-1). The complexes also display antioxidant behavior as determined by the ability to scavenge diphenylpicrylhydrazyl (dpph) and nitric oxide radicals...
April 20, 2017: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
https://www.readbyqxmd.com/read/28447330/seawater-drowning-associated-pneumonia-a-10-year-descriptive-cohort-in-intensive-care-unit
#4
Alexandre Robert, Pierre-Éric Danin, Hervé Quintard, Nicolas Degand, Nihal Martis, Denis Doyen, Céline Pulcini, Raymond Ruimy, Carole Ichai, Gilles Bernardin, Jean Dellamonica
BACKGROUND: Pneumonia is one of the major complications of drowning, but the optimal empirical antibiotic treatment is not clearly defined. Multidrug-resistant (MDR) bacteria and fungi have been identified in a recent series of freshwater drowning-associated pneumonia. However, microbial data in seawater drowning are scarce. The objective of the study is to describe the microorganisms isolated in early respiratory specimens obtained from seawater drowning-associated pneumonia and to provide their antibiotic susceptibility pattern...
December 2017: Annals of Intensive Care
https://www.readbyqxmd.com/read/28447026/genome-dynamics-of-escherichia-coli-during-antibiotic-treatment-transfer-loss-and-persistence-of-genetic-elements-in-situ-of-the-infant-gut
#5
Andreas Porse, Heidi Gumpert, Jessica Z Kubicek-Sutherland, Nahid Karami, Ingegerd Adlerberth, Agnes E Wold, Dan I Andersson, Morten O A Sommer
Elucidating the adaptive strategies and plasticity of bacterial genomes in situ is crucial for understanding the epidemiology and evolution of pathogens threatening human health. While much is known about the evolution of Escherichia coli in controlled laboratory environments, less effort has been made to elucidate the genome dynamics of E. coli in its native settings. Here, we follow the genome dynamics of co-existing E. coli lineages in situ of the infant gut during the first year of life. One E. coli lineage causes a urinary tract infection (UTI) and experiences several alterations of its genomic content during subsequent antibiotic treatment...
2017: Frontiers in Cellular and Infection Microbiology
https://www.readbyqxmd.com/read/28446177/the-susceptibility-to-fosfomycin-of-gram-negative-bacteria-isolates-from-urinary-tract-infection-in-the-czech-republic-data-from-a-unicentric-study
#6
Miroslav Fajfr, Miroslav Louda, Pavla Paterová, Lenka Ryšková, Jaroslav Pacovský, Josef Košina, Helena Žemličková, Miloš Broďák
BACKGROUND: Against a background of rapid increase of β-lactamase-producing or multi-resistant pathogenic bacteria and the resulting lack of effective antibiotic treatment, some older antibiotics have been tested for new therapeutic uses. One of these is fosfomycin, to which according to studies these resistant bacteria are very sensitive. Our study was designed because there is no data on the fosfomycin susceptibility rate in the Czech Republic. METHOD: In this study from January 2013 to June 2014 3295 unique isolates of Gram-negative bacteria which had caused urinary tract infections were examined...
April 26, 2017: BMC Urology
https://www.readbyqxmd.com/read/28446153/acceleration-and-suppression-of-resistance-development-by-antibiotic-combinations
#7
Shingo Suzuki, Takaaki Horinouchi, Chikara Furusawa
BACKGROUND: The emergence and spread of antibiotic resistance in bacteria is becoming a global public health problem. Combination therapy, i.e., the simultaneous use of multiple antibiotics, is used for long-term treatment to suppress the emergence of resistant strains. However, the effect of the combinatorial use of multiple drugs on the development of resistance remains elusive, especially in a quantitative assessment. RESULTS: To understand the evolutionary dynamics under combination therapy, we performed laboratory evolution of Escherichia coli under simultaneous addition of two-drug combinations...
April 26, 2017: BMC Genomics
https://www.readbyqxmd.com/read/28445786/metallo-%C3%AE-lactamase-inhibitors-by-bioisosteric-replacement-preparation-activity-and-binding
#8
Susann Skagseth, Sundus Akhter, Marianne H Paulsen, Zeeshan Muhammad, Silje Lauksund, Ørjan Samuelsen, Hanna-Kirsti S Leiros, Annette Bayer
Bacterial resistance is compromising the use of β-lactam antibiotics including carbapenems. The main resistance mechanism against β-lactams is hydrolysis of the β-lactam ring mediated by serine- or metallo-β-lactamases (MBLs). Although several inhibitors of MBLs have been reported, none has been developed into a clinically useful inhibitor. Mercaptocarboxylic acids are among the most prominent scaffolds reported as MBL inhibitors. In this study, the carboxylate group of mercaptocarboxylic acids was replaced with bioisosteric groups like phosphonate esters, phosphonic acids and NH-tetrazoles...
April 14, 2017: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/28445757/action-of-antimicrobial-peptides-on-bacterial-and-lipid-membranes-a-direct-comparison
#9
Joseph E Faust, Pei-Yin Yang, Huey W Huang
The bacterial membrane represents an attractive target for the design of new antibiotics to combat widespread bacterial resistance. Understanding how antimicrobial peptides (AMPs) and other membrane-active agents attack membranes could facilitate the design of new, effective antimicrobials. Despite intense study of AMPs on model membranes, we do not know how well the mechanism of attack translates to real biological membranes. To that end, we have characterized the attack of AMPs on Escherichia coli cytoplasmic membranes and directly compared this action to model membranes...
April 25, 2017: Biophysical Journal
https://www.readbyqxmd.com/read/28445079/multiple-antimicrobial-resistance-and-novel-point-mutation-in-fluoroquinolone-resistant-escherichia-coli-isolates-from-mangalore-india
#10
Santhosh Kogaluru Shivakumaraswamy, Deekshit Vijaya Kumar, Venugopal Moleyuru Nagarajappa, Iddya Karunasagar, Indrani Karunasagar
Fluoroquinolone resistance in bacteria is usually associated with mutations in the topoisomerase regions. We report a novel point mutation in fluoroquinolone-resistant Escherichia coli strains. E. coli isolated from the environment in and around Mangalore, India, were examined for their antimicrobial resistance profile to 12 antibiotics and for the antibiotic resistance genes by polymerase chain reaction. Of the 67 E. coli isolated, 24 (35.8%) were sensitive to all antibiotics and 43 (64.2%) showed resistance to at least one of the 12 antibiotics used in the study...
April 26, 2017: Microbial Drug Resistance: MDR: Mechanisms, Epidemiology, and Disease
https://www.readbyqxmd.com/read/28444315/towards-the-early-detection-of-%C3%AE-lactamase-producing-enterobacteriaceae-by-maldi-tof-ms-analysis
#11
Marina Oviaño, Marta Gómara, Maria José Barba, María José Revillo, Luis Pedro Barbeyto, Germán Bou
Objectives: Development of a novel MALDI-TOF MS-based method for the rapid detection of ESBL-producing Enterobacteriaceae. Methods: The method was evaluated in terms of sensitivity, specificity and turnaround time regarding the antibiotic used (cefotaxime, ceftazidime, ceftriaxone, cefpodoxime or cefepime) and the performance of the automated MBT STAR-BL software (Bruker Daltonik GmbH, Germany) relative to qualitative interpretation of spectra for detecting β-lactamase resistance by MALDI-TOF MS (Bruker Daltonik) in a collection of 11 isogenic Escherichia coli control strains expressing different β-lactamases...
April 24, 2017: Journal of Antimicrobial Chemotherapy
https://www.readbyqxmd.com/read/28443576/changes-in-bacterial-resistance-patterns-of-pediatric-urinary-tract-infections-in-%C3%A4-stanbul-and-rationale-for-empirical-antibiotic-therapy
#12
İbrahim Gökçe, Neslihan Çiçek, Serçin Güven, Ülger Altuntaş, Neşe Bıyıklı, Nurdan Yıldız, Harika Alpay
BACKGROUND: The causative agent spectrum and resistance patterns of urinary tract infection (UTI) in children are affected by many factors. AIMS: The aim of this study was to demonstrate the antibiotic resistance in UTI and changing ratio in antibiotic resistance by years. STUDY DESIGN: Retrospective cross-sectional study. METHODS: We analyzed antibiotic resistance patterns of isolated gram (-) bacteria during years 2011-2014 (study period 2) in children with UTI...
April 6, 2017: Balkan Medical Journal
https://www.readbyqxmd.com/read/28443072/distribution-of-integrons-and-phylogenetic-groups-among-enteropathogenic-escherichia-coli-isolates-from-children-5-years-of-age-in-delhi-india
#13
Taru Singh, Shukla Das, V G Ramachandran, Sayim Wani, Dheeraj Shah, Khan A Maroof, Aditi Sharma
Integrons by means of horizontal gene transfer carry multidrug resistance genes (MDR) among bacteria, including E. coli. The aim of this study was to determine the antibiotic resistance profiles and the genes associated with them, to gain insights in the distribution of phylogroups, prevalence, and characterization of class 1, 2 and 3 integrons among Enteropathogenic E. coli (EPEC) isolates, from children upto 5 years of age from Delhi and National Capital Region (NCR), India. A total of 120 E. coli isolates, including 80 from diarrheagenic E...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28442909/tat-functionalized-liposomes-for-the-treatment-of-meningitis-an-in-vitro-study
#14
Caterina Bartomeu Garcia, Di Shi, Thomas J Webster
Bacterial meningitis has become a global concern, because of the emergence of antibiotic-resistant bacteria. It has been demonstrated that liposomes can enter bacteria, thus providing a possible treatment for numerous infections, including meningitis. Fusogenic liposomes are pH-sensitive with a high capacity to fuse with the bacteria membrane and promote intracellular drug release. Moreover, this ability can be improved by using cell-penetrating peptides (such as Tat47-57, which is a peptide derived from the Tat protein of HIV)...
2017: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/28439624/evidence-for-the-formation-of-scbr-scbr2-heterodimers-and-identification-of-one-of-the-regulatory-targets-in-streptomyces-coelicolor
#15
Xiao Li, Juan Wang, Mingxin Shi, Weishan Wang, Christophe Corre, Keqian Yang
The homologous transcriptional regulators ScbR and ScbR2 have previously been identified as γ-butyrolactone (GBL) and antibiotic receptors, respectively. They regulate diverse physiological processes in Streptomyces coelicolor in response to GBL and antibiotic signals. In this study, ScbR and ScbR2 proteins were shown to interact using a bacterial two-hybrid system where adenylate cyclase activity was reconstituted in Escherichia coli BTH101. These ScbR/ScbR2 interactions in S. coelicolor were then demonstrated by co-immunoprecipitation...
April 24, 2017: Applied Microbiology and Biotechnology
https://www.readbyqxmd.com/read/28439602/antibiogram-profile-of-septic-meningitis-among-children-in-duhok-iraq
#16
Abdulrahman T Saadi, Nadir A Garjees, Aveen H Rasool
  To determine the prevalence of bacteria in the cerebrospinal fluid (CSF), and the antibiogram profile in pediatric patients with suspected meningitis. Methods: This descriptive study was conducted between January 2014 and January 2016 in the Hevi Paediatric Teaching Hospital in Duhok, Iraq. The CSF samples were withdrawn from 432 pediatric patients suspected of meningitis. The samples were cultured, and antibiotic sensitivity tests were performed.  Results: There were 33 (7.6%) culture positive cases among 432 CSF samples...
May 2017: Saudi Medical Journal
https://www.readbyqxmd.com/read/28439298/multi-drug-resistant-pathogenic-bacteria-in-the-gut-of-young-children-in-bangladesh
#17
Shirajum Monira, Syeda Antara Shabnam, Sk Imran Ali, Abdus Sadique, Fatema-Tuz Johura, Kazi Zillur Rahman, Nur Haque Alam, Haruo Watanabe, Munirul Alam
BACKGROUND: The gut of human harbors diverse commensal microbiota performing an array of beneficial role for the hosts. In the present study, the major commensal gut bacteria isolated by culturing methods from 15 children of moderate income families, aged between 10 and 24 months, were studied for their response to different antibiotics, and the molecular basis of drug resistance. RESULTS: Of 122 bacterial colonies primarily selected from Luria-Bertani agar, bacterial genera confirmed by analytical profile index (API) 20E(®) system included Escherichia as the predominant (52%) organism, followed by Enterobacter (16%), Pseudomonas (12%), Klebsiella (6%), Pantoea (6%), Vibrio (3%), and Citrobacter (3%); while Aeromonas and Raoultella were identified as the infrequently occurring genera...
2017: Gut Pathogens
https://www.readbyqxmd.com/read/28439261/interaction-of-bacterial-membrane-vesicles-with-specific-species-and-their-potential-for-delivery-to-target-cells
#18
Yosuke Tashiro, Yusuke Hasegawa, Masaki Shintani, Kotaro Takaki, Moriya Ohkuma, Kazuhide Kimbara, Hiroyuki Futamata
Membrane vesicles (MVs) are secreted from a wide range of microbial species and transfer their content to other cells. Although MVs play critical roles in bacterial communication, whether MVs selectively interact with bacterial cells in microbial communities is unclear. In this study, we investigated the specificity of the MV-cell interactions and evaluated the potential of MVs to target bacterial cells for delivery. MV association with bacterial cells was examined using a fluorescent membrane dye to label MVs...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28438179/genome-adaptive-evolution-of-lactobacillus-casei-under-long-term-antibiotic-selection-pressures
#19
Jicheng Wang, Xiao Dong, Yuyu Shao, Huiling Guo, Lin Pan, Wenyan Hui, Lai-Yu Kwok, Heping Zhang, Wenyi Zhang
BACKGROUND: The extensive use of antibiotics in medicine has raised serious concerns about biosafety. However, the effect of antibiotic application on the adaptive evolution of microorganisms, especially to probiotic bacteria, has not been well characterized. Thus, the objective of the current work was to investigate how antibiotic selection forces might drive genome adaptation using Lactobacillus (L.) casei Zhang as a model. METHODS: Two antibiotics, amoxicillin and gentamicin, were consistently applied to the laboratory culture of L...
April 24, 2017: BMC Genomics
https://www.readbyqxmd.com/read/28437685/rapid-label-free-identification-of-klebsiella-pneumoniae-antibiotic-resistant-strains-by-the-drop-coating-deposition-surface-enhanced-raman-scattering-method
#20
Youjin Cheong, Young Jin Kim, Heeyoon Kang, Samjin Choi, Hee Joo Lee
Although many methodologies have been developed to identify unknown bacteria, bacterial identification in clinical microbiology remains a complex and time-consuming procedure. To address this problem, we developed a label-free method for rapidly identifying clinically relevant multilocus sequencing typing-verified quinolone-resistant Klebsiella pneumoniae strains. We also applied the method to identify three strains from colony samples, ATCC70063 (control), ST11 and ST15; these are the prevalent quinolone-resistant K...
April 20, 2017: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
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