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treatment for escherichia coli enterotoxigenic

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https://www.readbyqxmd.com/read/29615989/intestinal-pathogenic-escherichia-coli-insights-for-vaccine-development
#1
REVIEW
Maricarmen Rojas-Lopez, Ricardo Monterio, Mariagrazia Pizza, Mickaël Desvaux, Roberto Rosini
Diarrheal diseases are one of the major causes of mortality among children under five years old and intestinal pathogenic Escherichia coli (InPEC) plays a role as one of the large causative groups of these infections worldwide. InPECs contribute significantly to the burden of intestinal diseases, which are a critical issue in low- and middle-income countries (Asia, Africa and Latin America). Intestinal pathotypes such as enteropathogenic E. coli (EPEC) and enterotoxigenic E. coli (ETEC) are mainly endemic in developing countries, while ETEC strains are the major cause of diarrhea in travelers to these countries...
2018: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29463305/lysozyme-improves-gut-performance-and-protects-against-enterotoxigenic-escherichia-coli-infection-in-neonatal-piglets
#2
Guangping Huang, Xiangqing Li, Dan Lu, Shen Liu, Xun Suo, Qiuyan Li, Ning Li
Diarrhea remains one of the leading causes of morbidity and mortality globally, with enterotoxigenic Escherichia coli (ETEC) constituting a major causative pathogen. The development of alternative treatments for diarrhea that do not involve chemotherapeutic drugs or result in antibiotic resistance is critical. Considering that lysozyme is a naturally occurring antimicrobial peptide, in a previous study we developed a transgenic pig line that expresses recombinant human lysozyme (hLZ) in its milk. In the present study, we examined the protective effects of the consumption of this milk against ETEC infection in neonatal piglets...
February 20, 2018: Veterinary Research
https://www.readbyqxmd.com/read/29344358/the-global-problem-of-childhood-diarrhoeal-diseases-emerging-strategies-in-prevention-and-management
#3
REVIEW
Margaret Mokomane, Ishmael Kasvosve, Emilia de Melo, Jeffrey M Pernica, David M Goldfarb
Acute diarrhoeal diseases remain a leading cause of global morbidity and mortality particularly among young children in resource-limited countries. Recent large studies utilizing case-control design, prospective sampling and more sensitive and broad diagnostic techniques have shed light on particular pathogens of importance and highlighted the previously under recognized impact of these infections on post-acute illness mortality and growth. Vaccination, particularly against rotavirus, has emerged as a key effective means of preventing significant morbidity and mortality from childhood diarrhoeal disease...
January 2018: Therapeutic Advances in Infectious Disease
https://www.readbyqxmd.com/read/29259822/efficacy-of-a-bovine-colostrum-and-egg-based-intervention-in-acute-childhood-diarrhoea-in-guatemala-a-randomised-double-blind-placebo-controlled-trial
#4
James T Gaensbauer, Mario A Melgar, Diva M Calvimontes, Molly M Lamb, Edwin J Asturias, Ingrid L Contreras-Roldan, Samuel R Dominguez, Christine C Robinson, Stephen Berman
Background: Treatments for paediatric diarrhoeal disease are limited. We assessed the impact of a bovine colostrum and egg-based treatment designed to reduce diarrhoea duration through non-specific and pathogen-directed mechanisms in children. Methods: Randomised, double-blind, placebo-controlled trial of PTM202, derived from bovine colostrum and hyperimmune hen's egg on the duration of acute diarrhoeal disease in Guatemalan children. PTM202 contains specific immunoglobulins that target rotavirus, enterotoxigenic Escherichia coli , Shiga toxin-producing E...
2017: BMJ Global Health
https://www.readbyqxmd.com/read/29166952/effects-of-dietary-live-yeast-supplementation-on-growth-performance-diarrhoea-severity-intestinal-permeability-and-immunological-parameters-of-weaned-piglets-challenged-with-enterotoxigenic-escherichia-coli-k88
#5
Lianqiang Che, Qin Xu, Cheng Wu, Yuheng Luo, Xiaobo Huang, Bo Zhang, Eric Auclair, Tadele Kiros, Zhengfeng Fang, Yan Lin, Shengyu Xu, Bin Feng, Jian Li, De Wu
This study aimed to investigate the effects of dietary live yeast (LY) supplementation on growth, intestinal permeability and immunological parameters of piglets challenged with enterotoxigenic Escherichia coli K88 (ETEC). Piglets weaned at 21 d were allocated into three treatments with six pens and six piglets per pen, receiving the control diet (CON), diets supplemented with antibiotics plus zinc oxide (ANT-ZnO) and LY (Saccharomyces cerevisiae strain CNCM I-4407), respectively, for a period of 2 weeks. On day 8, thirty-six piglets were selected as control without ETEC (CON), CON-ETEC, ANT-ZnO-ETEC and LY-ETEC groups challenged with ETEC until day 10 for sample collections...
December 2017: British Journal of Nutrition
https://www.readbyqxmd.com/read/29106325/diarrheagenic-escherichia-coli-and-shigella-with-high-rate-of-extended-spectrum-beta-lactamase-production-two-predominant-etiological-agents-of-acute-diarrhea-in-shiraz-iran
#6
Maneli Aminshahidi, Amir Arastehfar, Gholamreza Pouladfar, Esmayil Arman, Fereshteh Fani
This study was conducted to find the etiology of acute diarrhea in Iranian children and determine the antimicrobial resistance patterns. The pathogenic bacteria were recovered from 110/269 (40.9%) diarrheal fecal samples with the following profiles: the most predominant pathogen was diarrheagenic Escherichia coli (DEC) (43.6%), comprising enteroaggregative E. coli (23.6%), enteropathogenic E. coli (10.9%), enteroinvasive E. coli (5.5%), and enterotoxigenic E. coli (3.6%); Shigella spp. (37.3%), Salmonella spp...
December 2017: Microbial Drug Resistance: MDR: Mechanisms, Epidemiology, and Disease
https://www.readbyqxmd.com/read/29018435/-lactobacillus-plantarum-bsgp201683-isolated-from-giant-panda-feces-attenuated-inflammation-and-improved-gut-microflora-in-mice-challenged-with-enterotoxigenic-escherichia-coli
#7
Qian Liu, Xueqin Ni, Qiang Wang, Zhirong Peng, Lili Niu, Hengsong Wang, Yi Zhou, Hao Sun, Kangcheng Pan, Bo Jing, Dong Zeng
In this work, we searched for an effective probiotic that can help control intestinal infection, particularly enterotoxigenic Escherichia coli K88 (ETEC) invasion, in giant panda ( Ailuropoda melanoleuca ). As a potential probiotic strain, Lactobacillus plantarum BSGP201683 ( L. plantarum G83) was isolated from the feces of giant panda and proven beneficial in vitro . This study was aimed to evaluate the protective effect of L. plantarum G83 in mice challenged with ETEC. The mice were orally administered with 0...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28954839/young-pigs-consuming-lysozyme-transgenic-goat-milk-are-protected-from-clinical-symptoms-of-enterotoxigenic-escherichia-coli-infection
#8
Lydia C Garas, Caitlin A Cooper, Matthew W Dawson, Jane-Ling Wang, James D Murray, Elizabeth A Maga
Background: Diarrheal diseases in infancy and childhood are responsible for substantial morbidity and mortality in developing nations. Lysozyme, an antimicrobial component of human milk, is thought to play a role in establishing a healthy intestinal microbiota and immune system. Consumption of breast milk has been shown to prevent intestinal infections and is a recommended treatment for infants with diarrhea. Objective: This study aimed to examine the ability of lysozyme-rich goat milk to prevent intestinal infection...
November 2017: Journal of Nutrition
https://www.readbyqxmd.com/read/28943892/comparative-genomic-analysis-and-characteristics-of-nccp15740-the-major-type-of-enterotoxigenic-escherichia-coli-in-korea
#9
Taesoo Kwon, Si-Yun Chung, Young-Hee Jung, Su-Jin Jung, Sang-Gyun Roh, Je-Seop Park, Cheorl-Ho Kim, Won Kim, Young-Seok Bak, Seung-Hak Cho
BACKGROUND: Enterotoxigenic Escherichia coli (ETEC) cause infectious diarrhea and diarrheal death. However, the genetic properties of pathogenic strains vary spatially and temporally, making prevention and treatment difficult. In this study, the genomic features of the major type of ETEC in Korea from 2003 to 2011 were examined by whole-genome sequencing of strain NCCP15740, and a comparative genomic analysis was performed with O6 reference strains. RESULTS: The assembled genome size of NCCP15740 was 4,795,873 bp with 50...
2017: Gut Pathogens
https://www.readbyqxmd.com/read/28798800/effect-of-modified-pulsatilla-powder-on-enterotoxigenic-escherichia-coli-o101-induced-diarrhea-in-mice
#10
Jiankang Yu, Yuetian Zhang, Xu Song, Yi Yang, Renyong Jia, Xu Chen, Kai Sun, Li Li, Xinghong Zhao, Qiankun Cui, Qiuting Fu, Yuanfeng Zou, Lixia Li, Zhongqiong Yin
MPP can be effective in the treatment of E. coli O101-induced diarrhea in mice. MPP can improve the weight loss caused by diarrhea, increase spleen and thymus indices, and reduce the diarrhea index. MPP can reduce the number of WBC, regulate the level of cytokines, and regulate the intestinal microbial flora. These data suggest that MPP is a promising candidate for treatment of E. coli-induced diarrhea in humans and animals.
2017: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/28794894/swine-enteric-colibacillosis-diagnosis-therapy-and-antimicrobial-resistance
#11
REVIEW
Andrea Luppi
Intestinal infection with enterotoxigenic Escherichia coli (ETEC) is an important disease in swine resulting in significant economic losses. Knowledge about the epidemiology, the diagnostic approach and methods of control are of fundamental importance to tackle the disease. The ETEC causing neonatal colibacillosis mostly carry the fimbriae F4 (k88), F5 (k99), F6 (987P) or F41, while the ETEC of post-weaning diarrhoea carry the fimbriae F4 (k88) and F18. These fimbriae adhere to specific receptors on porcine intestinal brush border epithelial cells (enterocytes), starting the process of enteric infection...
2017: Porcine Health Management
https://www.readbyqxmd.com/read/28794036/persistent-transmissible-gastroenteritis-virus-infection-enhances-enterotoxigenic-escherichia-coli-k88-adhesion-by-promoting-epithelial-mesenchymal-transition-in-intestinal-epithelial-cells
#12
Lu Xia, Lei Dai, Qinghua Yu, Qian Yang
Transmissible gastroenteritis virus (TGEV) is a coronavirus characterized by diarrhea and high morbidity rates, and the mortality rate is 100% in piglets less than 2 weeks old. Pigs infected with TGEV often suffer secondary infection by other pathogens, which aggravates the severity of diarrhea, but the mechanisms remain unknown. Here, we hypothesized that persistent TGEV infection stimulates the epithelial-mesenchymal transition (EMT), and thus enterotoxigenic Escherichia coli (ETEC) can more easily adhere to generating cells...
November 1, 2017: Journal of Virology
https://www.readbyqxmd.com/read/28727032/probiotic-supplementation-protects-weaned-pigs-against-enterotoxigenic-escherichia-coli-k88-challenge-and-improves-performance-similar-to-antibiotics
#13
L Pan, P F Zhao, X K Ma, Q H Shang, Y T Xu, S F Long, Y Wu, F M Yuan, X S Piao
These studies evaluated the effects of probiotics (PB) as a potential substitute for antibiotics (AB) on diarrhea in relation to immune responses and intestinal health in weaned pigs challenged with enterotoxigenic (ETEC) K88 (Exp. 1) and the effects of PB on performance and nutrient digestibility in weaned pigs (Exp. 2). In Exp. 1, 24 weaned barrows (4.9 ± 0.4 kg initial BW) were randomly assigned to 1 of 4 treatments. The treatments consisted of pigs fed an unsupplemented corn-soybean meal basal diet and not challenged (NON-C) or challenged with ETEC K88 (CHA-C) on d 9 and pigs fed the same basal diet supplemented with AB (100 mg/kg zinc bacitracin, 50 mg/kg colistin sulfate, and 100 mg/kg olaquindox; CHA-AB) or 500 mg/kg PB ( and ; CHA-PB) and challenged with ETEC K88 on d 9...
June 2017: Journal of Animal Science
https://www.readbyqxmd.com/read/28607532/altered-cytokine-expression-and-barrier-properties-after-in-vitro-infection-of-porcine-epithelial-cells-with-enterotoxigenic-escherichia-coli-and-probiotic-enterococcus-faecium
#14
Martina Kern, Dorothee Günzel, Jörg R Aschenbach, Karsten Tedin, Angelika Bondzio, Ulrike Lodemann
The aim of the present study was to elucidate the effects of the probiotic feed additive Enterococcus faecium NCIMB 10415 (E. faecium) on porcine jejunal epithelial cells (IPEC-J2) during an in vitro challenge with enterotoxigenic Escherichia coli (ETEC). Cells were incubated with E. faecium, ETEC, or both, and the effects on barrier function and structure and intra- and intercellular signaling were determined. Coincubation with E. faecium abolished the ETEC-induced decrease in transepithelial resistance (Rt) (p ≤ 0...
2017: Mediators of Inflammation
https://www.readbyqxmd.com/read/28526080/post-weaning-diarrhea-in-pigs-risk-factors-and-non-colistin-based-control-strategies
#15
REVIEW
Mohamed Rhouma, John Morris Fairbrother, Francis Beaudry, Ann Letellier
Post-weaning diarrhea (PWD) is one of the most serious threats for the swine industry worldwide. It is commonly associated with the proliferation of enterotoxigenic Escherichia coli in the pig intestine. Colistin, a cationic antibiotic, is widely used in swine for the oral treatment of intestinal infections caused by E. coli, and particularly of PWD. However, despite the effectiveness of this antibiotic in the treatment of PWD, several studies have reported high rates of colistin resistant E. coli in swine...
May 19, 2017: Acta Veterinaria Scandinavica
https://www.readbyqxmd.com/read/28520998/medications-for-the-prevention-and-treatment-of-travellers-diarrhea
#16
David N Taylor, Davidson H Hamer, David R Shlim
Background: . Travellers' diarrhea (TD) remains one of the most common illnesses encountered by travellers to less developed areas of the world. Because bacterial pathogens such as enterotoxigenic Escherichia coli (ETEC), enteroaggregative E. coli , Campylobacter spp. and Shigella spp. are the most frequent causes, antibiotics have been useful in both prevention and treatment of TD. Methods.: Results of trials that assessed the use of medications for the prevention and treatment of TD were identified through PubMed and MEDLINE searches using search terms 'travellers' diarrhea', 'prevention' and 'treatment'...
April 1, 2017: Journal of Travel Medicine
https://www.readbyqxmd.com/read/28520997/resistant-pathogens-as-causes-of-traveller-s-diarrhea-globally-and-impact-s-on-treatment-failure-and-recommendations
#17
REVIEW
David R Tribble
Background: : Diarrhea is a frequent clinical syndrome affecting international travellers. Bacterial etiologic agents have a long history of emergent antimicrobial resistance against commonly used antibiotics. Current approaches applying first-line antimicrobial therapy are being challenged by increasingly resistant organisms. This review summarizes recent epidemiological and clinical evidence of antibiotic resistance among enteropathogens causing traveller's diarrhea and the subsequent impact on current treatment recommendations...
April 1, 2017: Journal of Travel Medicine
https://www.readbyqxmd.com/read/28419095/effectiveness-of-a-live-oral-human-rotavirus-vaccine-after-programmatic-introduction-in-bangladesh-a-cluster-randomized-trial
#18
RANDOMIZED CONTROLLED TRIAL
K Zaman, David A Sack, Kathleen M Neuzil, Mohammad Yunus, Lawrence H Moulton, Jonathan D Sugimoto, Jessica A Fleming, Ilias Hossain, Shams El Arifeen, Tasnim Azim, Mustafizur Rahman, Kristen D C Lewis, Andrea J Feller, Firdausi Qadri, M Elizabeth Halloran, Alejandro Cravioto, John C Victor
BACKGROUND: Rotavirus vaccines are now globally recommended by the World Health Organization (WHO), but in early 2009 WHO's Strategic Advisory Group of Experts on Immunization reviewed available data and concluded that there was no evidence for the efficacy or effectiveness of a two-dose schedule of the human rotavirus vaccine (HRV; Rotarix) given early at 6 and 10 wk of age. Additionally, the effectiveness of programmatic rotavirus vaccination, including possible indirect effects, has not been assessed in low-resource populations in Asia...
April 2017: PLoS Medicine
https://www.readbyqxmd.com/read/28199144/attachment-of-13-types-of-foodborne-bacteria-to-jalape%C3%A3-o-and-serrano-peppers-and-antibacterial-effect-of-roselle-calyx-extracts-sodium-hypochlorite-colloidal-silver-and-acetic-acid-against-these-foodborne-bacteria-on-peppers
#19
Esmeralda Rangel-Vargas, Carlos A Gómez-Aldapa, Reyna N Falfan-Cortes, María L Rodríguez-Marín, Angélica Godínez-Oviedo, Otilio A Acevedo-Sandoval, Javier Castro-Rosas
Chili peppers are a very important crop in Mexico. However, these peppers have been associated with Salmonella infection outbreaks in the United States, and Salmonella and diarrheagenic Escherichia coli pathotypes have been isolated from jalapeño and serrano peppers in Mexico. To decrease microbial contamination of fruits and vegetables, chemical agents are commonly used; however, chemical agents used to eliminate pathogenic bacteria on vegetables have a limited antimicrobial effect. Roselle ( Hibiscus sabdariffa ) calyces have been reported to have an antimicrobial effect on pathogenic bacteria...
March 2017: Journal of Food Protection
https://www.readbyqxmd.com/read/28056796/the-fecal-presence-of-enterotoxin-and-f4-genes-as-an-indicator-of-efficacy-of-treatment-with-colistin-sulfate-in-pigs
#20
Mohamed Rhouma, John Morris Fairbrother, William Thériault, Francis Beaudry, Nadia Bergeron, Sylvette Laurent-Lewandowski, Ann Letellier
BACKGROUND: Enterotoxigenic Escherichia coli (ETEC) strains producing multiple enterotoxins are important causes of post-weaning diarrhea (PWD) in pigs. The aim of the present study was to investigate the fecal presence of ETEC enterotoxin as well as F4 and F18 genes as an indicator of colistin sulfate (CS) efficacy for treatment of PWD in pigs. Forty-eight piglets were weaned at the age of 21 days, and were divided into four groups: challenged treated, challenged untreated, unchallenged treated, and unchallenged untreated...
January 5, 2017: BMC Microbiology
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