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https://www.readbyqxmd.com/read/28945021/-progress-of-new-antidepressant-drugs-development
#1
REVIEW
Xiao Zhang, Jun-Sheng Tian, Huan Liu, Xue-Mei Qin
Depression becomes more and more serious and has been greatly do harm to human's physical and mental health. WHO predicts that depression will become the second leading cause of abnormal death and disability by 2020. There is still the drug treatment as the first-line antidepressive therapy, but the effect of listed antidepressant drugs is not ideal. Therefore, discovery of new antidepressant drug of sunique, higher curative effect, less adverse reaction is the pursuit of pharmaceutical. The traditional Chinese medicine (TCM) of anti-depression and natural antidepressant in currently listed, drug development and drug discovery phase are summarized in this paper, aiming to provide reference for new antidepressant drug research...
January 2017: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/28944950/comparison-of-unilateral-versus-bilateral-pedicle-screw-fixation-in-transforaminal-lumbar-interbody-fusion-for-single-level-lumbar-degenerative-diseases-and-review-of-literature
#2
Hasan Serdar Işik, Özerk Okutan, Timur Yildirim, Elif Akpinar, Ali Yilmaz
AIM: There are some recognized treatment modalities in the literature for the treatment of lumbar degenerative diseases,which cause pain and avoidance of daily life activities for the patients.The most widely accepted algorithm in the literature is medical treatment,physical therapy and minimally invasive pain-relieving therapies,if necessary,followed by surgical interventions.The common procedure used in neurosurgery practice is the decompression of neural elements followed by fusion...
July 30, 2017: Turkish Neurosurgery
https://www.readbyqxmd.com/read/28944949/the-research-progress-of-mesenchymal-stem-cells-in-the-treatment-of-traumatic-brain-injury
#3
Gang Li, Yue Yang, Hua-Jiang Dong, Ling Lin
Traumatic brain injury (TBI) is the leading cause of mortality and morbidity in children and adults throughout the world. It is urgent to ameliorate TBI damage and reduce the disability and case-fatality rate. Stem cell therapy is another medical revolution after drug and surgical medication. Mesenchymal stem cells (MSCs) are a class of cells with significant self-renewal and multi-lineage differentiation properties and be favorable for the treatment of various diseases and injuries, it could be envisioned that MSCs transplantation may be a promising treatment for TBI...
July 16, 2017: Turkish Neurosurgery
https://www.readbyqxmd.com/read/28944741/the-application-of-nanoparticles-for-neuroprotection-in-acute-ischemic-stroke
#4
Lepei Chen, Xiaoling Gao
Stroke still represents one of the most common causes of death and disability worldwide. Acute ischemic stroke (AIS), caused by brain arterial occlusion resulting from a thrombus or embolus, is the most common form of stroke. However, current therapies in AIS are inadequate, and the only US FDA approved treatment is the thrombolytic drug Alteplase. Therefore, establishing effective therapeutic strategies for AIS is urgently needed. Using nanoparticle-based technologies to deliver neuroprotective agents to the ischemic area has attracted increasing attention of late...
October 2017: Therapeutic Delivery
https://www.readbyqxmd.com/read/28944700/participation-restrictions-among-adolescents-and-adults-with-neonatal-brachial-plexus-palsy-the-patient-perspective
#5
Menno van der Holst, Jeroen Groot, Duco Steenbeek, Willem Pondaag, Rob Ghh Nelissen, Thea Pm Vliet Vlieland
PURPOSE: To examine the impact of neonatal brachial plexus palsy (NBPP) on societal participation of adolescents and adults. METHODS: This cross-sectional study was conducted among patients with NBPP, aged ≥16 years, who had visited our NBPP clinic. Patients completed questions on the influence of NBPP on their choices regarding education/work and their work-performance, the Impact on Participation/Autonomy questionnaire and the Utrecht Scale for Evaluation of Rehabilitation-Participation (USER-P)...
September 24, 2017: Disability and Rehabilitation
https://www.readbyqxmd.com/read/28944699/compiling-standardized-information-from-clinical-practice-using-content-analysis-and-icf-linking-rules-in-a-goal-oriented-youth-rehabilitation-program
#6
Nadia A Lustenberger, Birgit Prodinger, Delgerjargal Dorjbal, Sara Rubinelli, Klaus Schmitt, Anke Scheel-Sailer
PURPOSE: To illustrate how routinely written narrative admission and discharge reports of a rehabilitation program for eight youths with chronic neurological health conditions can be transformed to the International Classification of Functioning, Disability and Health. METHODS: First, a qualitative content analysis was conducted by building meaningful units with text segments assigned of the reports to the five elements of the Rehab-Cycle(®): goal; assessment; assignment; intervention; evaluation...
September 23, 2017: Disability and Rehabilitation
https://www.readbyqxmd.com/read/28944679/risk-and-protective-factors-for-health-related-quality-of-life-among-persons-aging-with-hiv
#7
Annie L Nguyen, Candice J McNeil, S Duke Han, Scott D Rhodes
For persons living with HIV, health-related quality of life (HRQOL) may be threatened by physical and mental conditions but may be protected by positive psychological traits. We performed an exploratory look at the risk and protective factors for HRQOL in older adults living with HIV. Cross-sectional analyses of baseline data from the Rush Center of Excellence on Disparities in HIV and Aging (CEDHA), a community-based cohort of persons ages ≥50 living with HIV (n = 176) were performed. Analyses examined the relationship between risk/protective factors and two outcomes (i...
September 25, 2017: AIDS Care
https://www.readbyqxmd.com/read/28944644/effects-of-resistance-training-on-the-physical-condition-of-people-with-multiple-sclerosis
#8
Felipe J Aidar, André L Carneiro, Osvaldo Costa Moreira, Cláudia E Patrocínio de Oliveira, Nuno D Garrido, Victor Machado Reis, Igor Raineh, José M Vilaça, Dihogo Gama de Matos
OBJECTIVE: This study aimed to evaluate the effect of resistance training on the functional capacity of people with multiple sclerosis. SETTING: Two groups were defined intentionally and divided based on the Expanded Disability Status Scale (EDSS): an experimental group (EG) consisting of 11 individuals, 18.2% with an EDSS Score of 0 - 3.0, 72.8% with a score of 3.5 - 5.5 and 9.1% with a score of 6.0 - 7.5; and a control group (CG) consisting of 12 subjects, 25...
September 22, 2017: Journal of Sports Medicine and Physical Fitness
https://www.readbyqxmd.com/read/28944577/de-novo-mutations-in-hnrnpu-result-in-a-neurodevelopmental-syndrome
#9
T Michael Yates, Pradeep C Vasudevan, Kate E Chandler, Deirdre E Donnelly, Zornitza Stark, Simon Sadedin, Josh Willoughby, Meena Balasubramanian
Exome sequencing in the context of developmental disorders is a useful technique, but variants found need to be interpreted in the context of detailed phenotypic information. Whole gene deletions and loss-of-function-mutations in the HNRNPU gene have been associated with intellectual disability and seizures in some patients. However, a unifying syndromic phenotype has not been previously elucidated. Here, we report a total of seven patients (six patients identified through the Wellcome Trust Deciphering Developmental Disorders study, with one additional patient), who have heterozygous de novo mutations in HNRNPU...
September 25, 2017: American Journal of Medical Genetics. Part A
https://www.readbyqxmd.com/read/28944350/relationship-between-the-severity-of-malocclusion-and-oral-health-related-quality-of-life-a-systematic-review-and-meta-analysis
#10
Ling Sun, Hai Ming Wong, Colman P McGrath
PURPOSE: To investigate the impact of untreated malocclusion on different aspects of oral health-related quality of life (OHRQoL). MATERIALS AND METHODS: All relevant literature published up to February 18, 2016 was collected from nine electronic databases. To make studies comparable, studies that used the dental aesthetic index (DAI), index of orthodontic treatment need (IOTN), or index of complexity, outcome and need (ICON) to measure malocclusion and oral health impact profile (OHIP) to measure OHRQoL were selected for systematic review...
September 21, 2017: Oral Health & Preventive Dentistry
https://www.readbyqxmd.com/read/28944303/resveratrol-and-exercise-to-treat-functional-limitations-in-late-life-design-of-a-randomized-controlled-trial
#11
Andrew S Layne, Lisa M Krehbiel, Robert T Mankowski, Stephen D Anton, Christiaan Leeuwenburgh, Marco Pahor, Bhanuprasad Sandesara, Samuel S Wu, Thomas W Buford
Skeletal muscle mitochondrial function declines with age and is a key factor in the maintenance of physical function among older adults. Research studies from animals and humans have consistently demonstrated that exercise improves skeletal muscle mitochondrial function in early and middle adulthood. However, mitochondrial adaptations to both acute and chronic exercise are attenuated in late life. Thus, there is an important need to identify adjuvant therapies capable of augmenting mitochondrial adaptations to exercise (e...
June 2017: Contemporary Clinical Trials Communications
https://www.readbyqxmd.com/read/28944250/predictors-of-hip-pain-and-function-in-femoroacetabular-impingement-a-prospective-cohort-analysis
#12
Robert W Westermann, T Sean Lynch, Morgan H Jones, Kurt P Spindler, William Messner, Greg Strnad, James Rosneck
BACKGROUND: Validated patient-reported outcome measures (PROMs) of hip pain and function at the time of arthroscopy could be predictors of the final outcome. Little is known about how patient factors or pathologic intra-articular findings relate to hip pain or function at the time of surgery for those presenting with femoroacetabular impingement (FAI). PURPOSE: To evaluate all patient and operative factors that contribute to hip pain and dysfunction in patients with FAI...
September 2017: Orthopaedic Journal of Sports Medicine
https://www.readbyqxmd.com/read/28944249/return-to-play-following-shoulder-stabilization-a-systematic-review-and-meta-analysis
#13
REVIEW
Marc N Ialenti, Jeffrey D Mulvihill, Max Feinstein, Alan L Zhang, Brian T Feeley
BACKGROUND: Anterior shoulder instability can be a disabling condition for the young athlete; however, the best surgical treatment remains controversial. Traditionally, anterior shoulder instability was treated with open stabilization. More recently, arthroscopic repair of the Bankart injury with suture anchor fixation has become an accepted technique. HYPOTHESIS: No systematic reviews have compared the rate of return to play following arthroscopic Bankart repair with suture anchor fixation with the Bristow-Latarjet procedure and open stabilization...
September 2017: Orthopaedic Journal of Sports Medicine
https://www.readbyqxmd.com/read/28944241/disturbed-chromosome-segregation-and-multipolar-spindle-formation-in-a-patient-with-champ1-mutation
#14
Nobuhiko Okamoto, Yuki Tsuchiya, Ichiro Kuki, Toshiyuki Yamamoto, Hirotomo Saitsu, Daiju Kitagawa, Naomichi Matsumoto
BACKGROUND: Patients with intellectual disability (ID) typically exhibit significant defects in both intelligence and adaptive behavior. Aberration of several genes involved in proper progression of mitosis has been reported to underlie ID. Here, we report a new patient with a novel mutation of CHAMP1. METHODS: Whole exome sequencing (WES) analysis was performed. We isolated lymphoblast cells from the CHAMP1 patient and observed chromosome segregation. RESULTS: We identified a de novo frameshift mutation in CHAMP1...
September 2017: Molecular Genetics & Genomic Medicine
https://www.readbyqxmd.com/read/28944240/novel-compound-heterozygous-mutations-in-telo2-in-a-patient-with-severe-expression-of-you-hoover-fong-syndrome
#15
Shahida Moosa, Janine Altmüller, Troels Lyngbye, Rikke Christensen, Yun Li, Peter Nürnberg, Gökhan Yigit, Ida Vogel, Bernd Wollnik
BACKGROUND: Very recently, compound heterozygous loss-of-function mutations in TELO2 were shown to underlie the newly-described You-Hoover-Fong syndrome. TELO2 forms part of the co-chaperone triple T complex (TTT complex), which plays an important role in the maturation and stabilization of the phosphatidylinositol 3-kinase-related protein kinases (PIKKs). Patients with mutations in TELO2 present with microcephaly and associated intellectual disability, postnatal growth retardation and dysmorphic features...
September 2017: Molecular Genetics & Genomic Medicine
https://www.readbyqxmd.com/read/28944233/protein-structure-and-phenotypic-analysis-of-pathogenic-and-population-missense-variants-in-stxbp1
#16
Mohnish Suri, Jochem M G Evers, Roman A Laskowski, Sinead O'Brien, Kate Baker, Jill Clayton-Smith, Tabib Dabir, Dragana Josifova, Shelagh Joss, Bronwyn Kerr, Alison Kraus, Meriel McEntagart, Jenny Morton, Audrey Smith, Miranda Splitt, Janet M Thornton, Caroline F Wright
BACKGROUND: Syntaxin-binding protein 1, encoded by STXBP1, is highly expressed in the brain and involved in fusing synaptic vesicles with the plasma membrane. Studies have shown that pathogenic loss-of-function variants in this gene result in various types of epilepsies, mostly beginning early in life. We were interested to model pathogenic missense variants on the protein structure to investigate the mechanism of pathogenicity and genotype-phenotype correlations. METHODS: We report 11 patients with pathogenic de novo mutations in STXBP1 identified in the first 4293 trios of the Deciphering Developmental Disorder (DDD) study, including six missense variants...
September 2017: Molecular Genetics & Genomic Medicine
https://www.readbyqxmd.com/read/28944180/surgical-management-of-atrial-fibrillation-at-the-time-of-septal-myectomy
#17
Eduard Quintana, James L Cox
Atrial fibrillation (AF) may appear during the natural clinical course of hypertrophic cardiomyopathy (HCM). It is regarded as a complication of HCM and is a marker of advanced disease. AF is more likely to occur in untreated, obstructive HCM. Unfortunately, this represents a turning point that puts patients at increased risk of further disability, stroke and death. The presence of obstruction is an indication to proceed with septal myectomy to improve or resolve symptoms by ameliorating diastolic dysfunction...
July 2017: Annals of Cardiothoracic Surgery
https://www.readbyqxmd.com/read/28944139/a-novel-cask-mutation-identified-in-siblings-exhibiting-developmental-disorders-with-without-microcephaly
#18
Toshiyuki Seto, Takashi Hamazaki, Satsuki Nishigaki, Satoshi Kudo, Haruo Shintaku, Yumiko Ondo, Keiko Shimojima, Toshiyuki Yamamoto
The calcium/calmodulin-dependent serine protein kinase gene (CASK) mutations are associated with various neurological disorders; a syndrome of intellectual disability (ID) and microcephaly with pontine and cerebellar hypoplasia (MICPCH), FG syndrome, X-linked ID with/without nystagmus, epileptic encephalopathy, and autistic spectrum disorder (ASD). Next generation sequencing was performed to elucidate genetic causes in siblings exhibiting developmental disorders, and a novel CASK mutation, c.1424G>T (p.Ser475Ile), was detected in a male patient with ID, ASD, and microcephaly...
August 2017: Intractable & Rare Diseases Research
https://www.readbyqxmd.com/read/28944127/minimally-invasive-versus-open-laminectomy-discectomy-transforaminal-lumbar-and-posterior-lumbar-interbody-fusions-a-systematic-review
#19
REVIEW
Allicia O Imada, Tridu R Huynh, Doniel Drazin
Minimally invasive spine surgeries (MISS) are becoming increasingly favored as alternatives to open spine procedures because of the reduced blood loss, postoperative pain, and recovery time. Studies have shown mixed results regarding the efficacy and safety of minimally invasive procedures compared to the traditional, open counterparts. The objectives of this systematic analysis are to compare clinical outcomes between the three MISS and open procedures: (1) laminectomy/discectomy, (2) transforaminal lumbar interbody fusion (TLIF), and (3) posterior lumbar interbody fusion (PLIF)...
July 18, 2017: Curēus
https://www.readbyqxmd.com/read/28943849/an-intention-driven-semi-autonomous-intelligent-robotic-system-for-drinking
#20
Zhijun Zhang, Yongqian Huang, Siyuan Chen, Jun Qu, Xin Pan, Tianyou Yu, Yuanqing Li
In this study, an intention-driven semi-autonomous intelligent robotic (ID-SIR) system is designed and developed to assist the severely disabled patients to live independently. The system mainly consists of a non-invasive brain-machine interface (BMI) subsystem, a robot manipulator and a visual detection and localization subsystem. Different from most of the existing systems remotely controlled by joystick, head- or eye tracking, the proposed ID-SIR system directly acquires the intention from users' brain. Compared with the state-of-art system only working for a specific object in a fixed place, the designed ID-SIR system can grasp any desired object in a random place chosen by a user and deliver it to his/her mouth automatically...
2017: Frontiers in Neurorobotics
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