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https://www.readbyqxmd.com/read/28724200/effect-of-memantine-on-serum-levels-of-neuron-specific-enolase-and-on-the-glasgow-coma-scale-in-patients-with-moderate-traumatic-brain-injury
#1
Majid Mokhtari, Hossein Nayeb-Aghaei, Mehran Kouchek, Mir Mohammad Miri, Reza Goharani, Arash Amoozandeh, Sina Akhavan Salamat, Mohammad Sistanizad
Traumatic brain injury (TBI) is a major cause of disability and death globally. Despite significant progress in neuromonitoring and neuroprotection, pharmacological interventions have failed to generate favorable results. We examined the effect of memantine on serum levels of neuron-specific enolase (NSE), a marker of neuronal damage, and the Glasgow Coma Scale (GCS) in patients with moderate TBI. Patients were randomly assigned to the control group (who received standard TBI management) and the treatment group (who, alongside their standard management, received enteral memantine 30 mg twice daily for 7 days)...
July 19, 2017: Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/28724039/treatment-of-digital-ulcers-in-systemic-sclerosis-case-series-study-of-thirteen-patients-and-discussion-on-outcome
#2
Yahia Abuowda, Raquel Sousa Almeida, Ana Alves Oliveira, Petra Pego, Cristina Santos, João Matos-Costa
Introduction: In systemic sclerosis (SSc), digital ulcers (DU) are debilitating and recurrent. They are markers of prognosis and are associated with disability and mortality. Treatment strategies have been developed to block the proposed mechanisms of this complication. Objective: Clinical description of a population of SSc patients with DU, treatment, complications and outcome. Method: Analysis of 48 SSc patients meeting 2013 ACR-EULAR criteria, followed between 1999-2015; 13 patients had DU...
May 2017: Revista da Associação Médica Brasileira
https://www.readbyqxmd.com/read/28723854/use-of-colorectal-cancer-screening-among-people-with-mobility-disability
#3
Miriam Gofine, Thelma J Mielenz, Sowmya Vasan, Benjamin Lebwohl
GOALS: We aimed to assess use of colorectal cancer screening (CRCS) as per United States Preventive Task Force guidelines among people with mobility disability using a nationally representative data set. BACKGROUND: Individuals with mobility disability have decreased access to health care services, but the impact of mobility disability on CRCS has not been investigated. STUDY: Data from the 2013 National Health Interview Survey were used to estimate sociodemographic characteristics of adults with mobility disability, prevalence of CRCS, and odds of CRCS given mobility disability among Americans aged 50 to 75...
July 18, 2017: Journal of Clinical Gastroenterology
https://www.readbyqxmd.com/read/28723772/anatomic-investigation-of-lumbar-transforaminal-fenestration-approach-and-its-clinical-application-in-far-lateral-disc-herniation
#4
Baoshan Xu, Haiwei Xu, Jean Destandau, Xinlong Ma, Jian He, Qun Xia, Ning Ji, Qiang Yang, Yue Liu, Hongfeng Jiang
Treating lumbar disease at the intervertebal foramina is controversial because we lack an approach providing sufficient exposure and preserving spinal stability. The primary objective of this study was to investigate the feasibility of the transforaminal fenestration (TFF) approach for treating lumbar disease involving the intervertebal foramina.In the anatomic study of 30 adult cadaveric lumbar spine specimens, the TFF approach was used from L1 to S1. The scope of resection was measured manually and on 3D CT images...
July 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28723766/lady-with-wings-a-case-report-of-giant-neurofibromatosis-type-i
#5
Suraj Maharjan, Xiucun Li, Jianli Cui, Yang Liu, Laijin Lu
RATIONALE: Neurofibromatosis type I (NF-I) accounts for approximately 90% of neurofibromatosis. NF-I is an autosomal dominant genetic disease which results from the gene mutation of NF-I situated in chromosome 17q11.2. PATIENT CONCERNS: A 32-year-old lady presented with a giant wing like structure on her back which started growing from her childhood. DIAGNOSIS: A diagnosis of NF-I was confirmed as she presented with multiple cutaneous nodules, multiple café-au-lait macules of different sizes, scoliosis deformity, and positive family history of neurofibroma...
July 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28723737/how-to-choose-when-implants-of-adjacent-height-both-fit-the-disc-space-properly-in-single-level-cervical-artificial-disc-replacement
#6
Xin Rong, Jigang Lou, Huibo Li, Yang Meng, Hao Liu
In cervical artificial disc replacement (C-ADR), sometimes we encountered with such cases that implants of adjacent height both fit the target disc space properly. No study was available discussing the choice of implant height and the clinical outcomes under such circumstance. The purpose of this study was to evaluate the impact of different implant heights on the clinical outcomes and radiographic results when the implants of adjacent height both fit the disc space properly. This retrospective study included 34 patients underwent single-level C-ADR at the C5-C6 level at our institution...
July 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28723649/observation-of-elevated-fasting-blood-glucose-and-functional-outcome-after-ischemic-stroke-in-patients-with-and-without-diabetes
#7
Wen-Yu Xue, Yan-Cheng Xu, Yu-Wen Wu, Miao Yang
During May 2015 to October 2016, this prospective study enrolled a total of 438 patients with acute ischemic stroke(AIS), meanwhile, records regarding the severity of initial stroke and neurological outcomes at three months, as well as other examination were completed in patients on admission, as well as the measurement and evaluation of fasting blood glucose(FBG) levels. At admission, the median FBG levels in patients with a minor stroke (n=124), [P<0.001]) was significantly lower than that observed in patients with other degrees of stroke...
July 7, 2017: Oncotarget
https://www.readbyqxmd.com/read/28722772/understanding-leisure-time-physical-activity-voices-of-people-with-ms-who-have-moderate-to-severe-disability-and-their-family-caregivers
#8
Afolasade Fakolade, Julie Lamarre, Amy Latimer-Cheung, Trisha Parsons, Sarah A Morrow, Marcia Finlayson
BACKGROUND: Physical activity (PA) is beneficial for all people, yet people affected by multiple sclerosis (MS) find regular PA challenging. These people may include individuals with the disease who have moderate-to-severe disability and their family caregivers. For researchers and clinicians to effectively promote PA among caregiver/care-recipient dyads with moderate-to-severe MS, a comprehensive understanding of the shared PA experiences of these dyads would be beneficial. OBJECTIVE: We explored shared experiences of caregiver/care-recipient dyads affected by moderate-to-severe MS about PA and directions for intervention...
July 19, 2017: Health Expectations: An International Journal of Public Participation in Health Care and Health Policy
https://www.readbyqxmd.com/read/28722685/neural-control-of-finger-movement-via-intracortical-brain-machine-interface
#9
Zachary T Irwin, Karen E Schroeder, Philip P Vu, Autumn J Bullard, Derek M Tat, Chrono S Nu, Alex Vaskov, Samuel R Nason, David E Thompson, Nicole Bentley, Parag G Patil, Cynthia A Chestek
OBJECTIVE: Intracortical brain-machine interfaces (BMIs) are a promising source of prosthesis control signals for individuals with severe motor disabilities. Previous BMI studies have primarily focused on predicting and controlling whole-arm movements; precise control of hand kinematics, however, has not been fully demonstrated. Here, we investigate the continuous decoding of precise finger movements in rhesus macaques. APPROACH: In order to elicit precise and repeatable finger movements, we have developed a novel behavioral task paradigm which requires the subject to acquire virtual fingertip position targets...
July 19, 2017: Journal of Neural Engineering
https://www.readbyqxmd.com/read/28722662/antibiotic-prophylaxis-for-infections-in-patients-with-acute-stroke-a-systematic-review-and-meta-analysis-of-randomized-controlled-trials
#10
Yan-Guo Xi, Xu Tian, Wei-Qing Chen, Sai Zhang, Shan Zhang, Wei-Dan Ren, Qi-Jun Pang, Guo-Tao Yang, Zhi-Ming Yang
OBJECTIVE: Infections are frequent after stroke and lead to increased mortality and neurological disability. Antibiotic prophylaxis has potential of decreasing the risk of infections and mortality and improving poor functional outcome. Several studies evaluated antibiotic prophylaxis for infections in acute stroke patients have generated conflicting results. The systematic review of randomized clinical trials (RCTs) aimed at comprehensively assessing the evidence of antibiotic prophylaxis for the treatment of acute stroke patients...
July 6, 2017: Oncotarget
https://www.readbyqxmd.com/read/28722607/mucosal-leishmaniasis-a-retrospective-study-of-327-cases-from-an-endemic-area-of-leishmania-viannia-braziliensis
#11
Carolina Cincurá, Clara Mônica F de Lima, Paulo R L Machado, Jamary Oliveira-Filho, Marshall J Glesby, Marcus M Lessa, Edgar M Carvalho
Mucosal leishmaniasis (ML) is observed only in about 3% of patients with American tegumentary leishmaniasis (ATL) but has a high potential for destructive, disfiguring, and disabling sequelae. Prior reports of clinical and epidemiologic features of ML are limited by small numbers of cases. In this study, we evaluated changes in the demographic features and clinical presentation of ML in an endemic area of Leishmania braziliensis transmission over a period of 20 years. The charts of 327 patients with ML diagnosed between 1995 and 2014 were reviewed...
July 10, 2017: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/28722536/travel-burden-associated-with-granulocyte-colony-stimulating-factor-administration-in-a-medicare-aged-population-a-geospatial-analysis
#12
J Mark Stephens, Mark Bensink, Charles Bowers, Christopher S Hollenbeak
OBJECTIVE: Prophylaxis with granulocyte colony-stimulating factors (G-CSFs) is recommended for patients receiving myelosuppressive chemotherapy regimens with a high risk of febrile neutropenia (FN). G-CSFs should be administered starting the day after chemotherapy, necessitating return trips to the oncology clinic at the end of each cycle. We examined the travel burden related to prophylactic G-CSF injections after chemotherapy in the United States (US). METHODS: We used 2012-2014 Medicare claims data to identify a national cohort of beneficiaries age 65+ with non-myeloid cancers who received both chemotherapy and prophylactic G-CSFs...
July 19, 2017: Current Medical Research and Opinion
https://www.readbyqxmd.com/read/28721959/a-study-of-falls-among-elderly-persons-in-a-rural-area-of-haryana
#13
Aniket Sirohi, Ravneet Kaur, Anil Kumar Goswami, Kalaivani Mani, Baridalyne Nongkynrih, Sanjeev Kumar Gupta
BACKGROUND: Falls are a common, disabling, and frequently fatal health concern among elderly persons. Assessment of the prevalence of falls and associated factors can lead to the identification of corrective measures, which can help in preventing falls and their consequent effects on health and well-being of the elderly. OBJECTIVES: The objective is to determine the prevalence of falls among elderly persons in a rural area and to study the association of falls with sociodemographic variables and selected health conditions...
April 2017: Indian Journal of Public Health
https://www.readbyqxmd.com/read/28721930/pharmacoresistant-epileptic-eyelid-twitching-in-a-child-with-a-mutation-in-syngap1
#14
Tetsuya Okazaki, Yoshiaki Saito, Rika Hiraiwa, Shinji Saitoh, Masachika Kai, Kaori Adachi, Yoko Nishimura, Eiji Nanba, Yoshihiro Maegaki
SYNGAP1 gene mutation has been associated with epilepsy which is often drug resistant, with seizure types including eyelid myoclonia. However, detailed descriptions, including ictal video-EEG, have not been reported. We report the case of a 4-year-old boy who developed recurrent epileptic eyelid twitching at 1 year and 5 months of age. Seizures gradually increased in frequency to more than 50 times per day and manifested with upward eye deviation, motion arrest, loss of consciousness, and eyelid twitching lasting for five seconds...
July 19, 2017: Epileptic Disorders: International Epilepsy Journal with Videotape
https://www.readbyqxmd.com/read/28721785/creating-calm-amid-confrontation
#15
Bradley Squirrell
In my first year of training, I had a placement on a challenging behaviours unit for people with a learning disability. One night shift at about 11.30pm a service user, who I will call Charlotte, became physically and verbally aggressive towards staff members. This was due to an incident earlier in the day with another service user.
July 19, 2017: Nursing Standard
https://www.readbyqxmd.com/read/28721760/stroke-in-childhood
#16
Lynne Pearce
Essential facts About 400 children a year have a stroke in the UK. Many are left with severe disability. While there have been improvements in diagnosis and treatment in recent years, the condition is still not as well recognised as stroke in adults. Experts believe that greater awareness among parents and healthcare professionals could lead to speedier diagnosis and minimise risk of severe long-term health problems.
July 19, 2017: Nursing Standard
https://www.readbyqxmd.com/read/28721628/disease-activity-handgrip-strengths-and-hand-dexterity-in-patients-with-rheumatoid-arthritis
#17
D Palamar, G Er, R Terlemez, I Ustun, G Can, M Saridogan
Rheumatoid arthritis (RA) is a chronic inflammatory disease affecting the hand joints and leading to impairment in hand functions. Evaluation of functional impairment is necessary for assessing patient's quality of life, disease activity, and treatment outcome. To date, many scientific studies assessed the disease activity of patients with RA, but little attention has been carried out to assess these patients' hand functions and dexterity. The purposes of this study were to determine the clinical relevance of the Quick Disabilities of the Arm, Shoulder, and Hand (QuickDASH), hand dexterity with the Purdue Pegboard Test (PPT), and handgrip strength and pinch strengths of RA patients and to look into their relation between each other...
July 18, 2017: Clinical Rheumatology
https://www.readbyqxmd.com/read/28721575/gastroparesis-medical-and-therapeutic-advances
#18
REVIEW
Christopher M Navas, Nihal K Patel, Brian E Lacy
Gastroparesis is a chronic, bothersome, and often disabling neuromuscular disorder of the upper gastrointestinal tract. The most frequently reported symptoms of gastroparesis include nausea, vomiting, epigastric pain, early satiety, and unintentional weight loss. Etiologies of gastroparesis include diabetes, connective tissue disorders, prior infection, mesenteric ischemia, and post-surgical complications. The largest category of gastroparesis patients is comprised of those in whom no definitive cause can be identified (idiopathic gastroparesis)...
July 18, 2017: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/28721501/examining-transgender-health-through-the-international-classification-of-functioning-disability-and-health-s-icf-contextual-factors
#19
REVIEW
Melissa Jacob, Steven R Cox
PURPOSE: For many transgender individuals, medical intervention is necessary to live as their desired gender. However, little is known about Contextual Factors (i.e., Environmental and Personal) that may act as facilitators and barriers in the health of transgender individuals. Therefore, this paper sought to examine Contextual Factors of the World Health Organization's International Classification of Functioning, Disability, and Health that may facilitate or negatively impact the physical, psychological, and social functioning of transgender individuals...
July 18, 2017: Quality of Life Research
https://www.readbyqxmd.com/read/28721447/direct-repair-of-the-sagittal-band-for-extensor-tendon-subluxation-caused-by-finger-flicking
#20
In Tae Hong, Chi Hoon Oh, Young Suk Sim, Soo Hong Han
PURPOSE: For patients with metacarpophalangeal (MCP) extensor tendon subluxation caused by finger flicking injury, we performed an extensor tendon realignment and direct repair technique. The purpose of this study was to evaluate the clinical outcome after direct repair of the sagittal band in patients with MCP extensor tendon subluxation caused by finger flicking injury and to introduce the repair technique. METHODS: A total of 26 patients with a mean age of 39...
July 18, 2017: Der Orthopäde
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