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https://www.readbyqxmd.com/read/28110287/aspirin-to-inhibit-sepsis-antisepsis-randomised-controlled-trial-protocol
#1
Damon P Eisen, Elizabeth M Moore, Karin Leder, Jessica Lockery, Emma S McBryde, John J McNeil, David Pilcher, Rory Wolfe, Robyn L Woods
INTRODUCTION: Sepsis is a leading global cause of morbidity and mortality, and is more common at the extremes of age. Moreover, the cost of in-hospital care for elderly patients with sepsis is significant. There are indications from experimental and observational studies that aspirin may reduce inflammation associated with infection. This paper describes the rationale and design of the AspiriN To Inhibit SEPSIS (ANTISEPSIS) trial, a substudy of ASPirin in Reducing Events in the Elderly (ASPREE)...
January 20, 2017: BMJ Open
https://www.readbyqxmd.com/read/28110260/road-traffic-injuries-among-children-and-adolescents-in-singapore-who-is-at-greatest-risk
#2
Shu-Ling Chong, Arif Tyebally, Su Yah Chew, Yang Chern Lim, Xun Yi Feng, Sock Teng Chin, Lois K Lee
INTRODUCTION: Pediatric road traffic injuries remain a significant cause of death and disability in many countries in Asia, despite the implementation of road traffic safety laws. We aim to describe the injuries, the use of restraints among road users, and risk factors associated with severe injuries for children in Singapore. METHODS: We performed a retrospective chart review of road traffic injuries presenting to the only two pediatric tertiary care hospitals in Singapore, from January 2012 to April 2016...
January 19, 2017: Accident; Analysis and Prevention
https://www.readbyqxmd.com/read/28110116/use-of-antipsychotics-benzodiazepine-derivatives-and-dementia-medication-among-older-people-with-intellectual-disability-and-or-autism-spectrum-disorder-and-dementia
#3
Anna Axmon, Jimmie Kristensson, Gerd Ahlström, Patrik Midlöv
BACKGROUND: Although people with intellectual disability (ID) and people with dementia have high drug prescription rates, there is a lack of studies investigating drug use among those with concurrent diagnoses of ID and dementia. AIM: To investigate the use of antipsychotics, benzodiazepine derivatives, and drugs recommended for dementia treatment (anticholinesterases [AChEIs] and memantine) among people with ID and dementia. METHODS AND PROCEDURES: Having received support available for people with ID and/or autism spectrum disorder (ASD) was used as a proxy for ID...
January 18, 2017: Research in Developmental Disabilities
https://www.readbyqxmd.com/read/28110044/dopaminergic-modulation-of-multi-muscle-synergies-in-postural-tasks-performed-by-patients-with-parkinson-s-disease
#4
Ali Falaki, Xuemei Huang, Mechelle M Lewis, Mark L Latash
BACKGROUND: Postural instability is one of most disabling motor symptoms in Parkinson's disease. Indices of multi-muscle synergies are new measurements of postural stability. OBJECTIVES: We explored the effects of dopamine-replacement drugs on multi-muscle synergies stabilizing center of pressure coordinate and their adjustments prior to a self-triggered perturbation in patients with Parkinson's disease. We hypothesized that both synergy indices and synergy adjustments would be improved on dopaminergic drugs...
January 11, 2017: Journal of Electromyography and Kinesiology
https://www.readbyqxmd.com/read/28109706/cost-effectiveness-of-13-valent-pneumococcal-conjugate-vaccination-in-mongolia
#5
Neisha Sundaram, Cynthia Chen, Joanne Yoong, Munkh-Erdene Luvsan, Kimberley Fox, Amarzaya Sarankhuu, Sophie La Vincente, Mark Jit
OBJECTIVE: The Ministry of Health (MOH), Mongolia, is considering introducing 13-valent pneumococcal conjugate vaccine (PCV13) in its national immunization programme to prevent the burden of disease caused by Streptococcus pneumoniae. This study evaluates the cost-effectiveness and budget impact of introducing PCV13 compared to no PCV vaccination in Mongolia. METHODS: The incremental cost-effectiveness ratio (ICER) of introducing PCV13 compared to no PCV vaccination was assessed using an age-stratified static multiple cohort model...
January 18, 2017: Vaccine
https://www.readbyqxmd.com/read/28109695/korean-translation-and-validation-of-the-whoqol-dis-for-people-with-spinal-cord-injury-and-stroke
#6
Kuem Ju Lee, Hye In Jang, Hyun Choi
BACKGROUND: The QOL assessment to measure disabilities has needed to survey studies for a variety of fields. Until now, no Korean translation of the World Health Organization Quality of Life-disability (WHOQOL-DIS) module existed. OBJECTIVE/HYPOTHESIS: We translated and cross-culturally adapted the WHOQOL-DIS module into Korean, testing its reliability and validity with Korean spinal cord injury and stroke patients. METHODS: The translation occurred using the methodology recommended by WHO...
January 1, 2017: Disability and Health Journal
https://www.readbyqxmd.com/read/28109694/sirt1-as-a-potential-biomarker-of-response-to-treatment-with-glatiramer-acetate-in-multiple-sclerosis
#7
Daniel Hewes, Alexandru Tatomir, Adam M Kruszewski, Gautam Rao, Cosmin A Tegla, Jonathan Ciriello, Vingh Nguyen, Walter Royal, Christopher Bever, Violeta Rus, Horea Rus
SIRT1, a NAD dependent histone and protein deacetylase, is a member of the histone deacetylase class III family. We previously showed that SIRT1 mRNA expression is significantly lower in peripheral blood mononuclear cells (PBMCs) of multiple sclerosis (MS) patients during relapses than in stable patients. We have now investigated SIRT1 as a possible biomarker to predict relapse as well as responsiveness to glatiramer acetate (GA) treatment in relapsing-remitting MS (RRMS) patients. Over the course of 2years, a cohort of 15 GA-treated RRMS patients were clinically monitored using the Expanded Disability Status Scale and assessed for MS relapses...
January 18, 2017: Experimental and Molecular Pathology
https://www.readbyqxmd.com/read/28109642/non-routine-discharge-from-military-service-mental-illness-substance-use-disorders-and-suicidality
#8
Emily Brignone, Jamison D Fargo, Rebecca K Blais, Marjorie E Carter, Matthew H Samore, Adi V Gundlapalli
INTRODUCTION: Mental illness and substance use disorders among newly returned military service members pose challenges to successful reintegration into civilian life and, in extreme cases, may lead to outcomes such as incarceration, homelessness, and suicide. One potential early indicator for these difficulties is non-routine discharge from military service. METHODS: Using data from the Veterans Health Administration (VHA) for 443,360 active duty service Veterans who deployed to Afghanistan and Iraq and subsequently utilized VHA services between Fiscal Years 2004 and 2013, this study examined risk for receiving a VHA-documented diagnosis of mental illness, substance use disorders, and suicidality as a function of discharge type, controlling for demographic and military service covariates...
January 18, 2017: American Journal of Preventive Medicine
https://www.readbyqxmd.com/read/28109566/effectiveness-of-virtual-reality-rehabilitation-for-children-and-adolescents-with-cerebral-palsy-an-updated-evidence-based-systematic-review
#9
REVIEW
D K Ravi, N Kumar, P Singhi
BACKGROUND: The use of virtual reality systems in the motor rehabilitation of children with cerebral palsy is new, and thus the scientific evidence for its effectiveness needs to be evaluated through a systematic review. OBJECTIVE: To provide updated evidence-based guidance for virtual reality rehabilitation in sensory and functional motor skills of children and adolescents with cerebral palsy. DATA SOURCES: PubMed, PEDro, Web of Science, OTseeker, PsycINFO and Cochrane Library were searched from their earliest records up to 1 June, 2016...
September 27, 2016: Physiotherapy
https://www.readbyqxmd.com/read/28109562/primary-cesarean-delivery-patterns-among-women-with-physical-sensory-or-intellectual-disabilities
#10
Blair G Darney, Frances M Biel, Brian P Quigley, Aaron B Caughey, Willi Horner-Johnson
BACKGROUND: Little is known about the relationship between disability and mode of delivery. Prior research has indicated elevated risk of cesarean delivery among women with certain disabilities, but has not examined patterns across multiple types of disability or by parity. OBJECTIVE: This study sought to determine whether physical, sensory, or intellectual and developmental disabilities are independently associated with primary cesarean delivery. METHODS: We conducted a retrospective cohort study of all deliveries in California from 2000 to 2010 using linked birth certificate and hospital discharge data...
January 18, 2017: Women's Health Issues: Official Publication of the Jacobs Institute of Women's Health
https://www.readbyqxmd.com/read/28109306/impact-of-trauma-system-structure-on-injury-outcomes-a-systematic-review-protocol
#11
Lynne Moore, Howard Champion, Gerard O'Reilly, Ari Leppaniemi, Peter Cameron, Cameron Palmer, Fikri M Abu-Zidan, Belinda Gabbe, Christine Gaarder, Natalie Yanchar, Henry Thomas Stelfox, Raul Coimbra, John Kortbeek, Vanessa Noonan, Amy Gunning, Luke Leenan, Malcolm Gordon, Monty Khajanchi, Michèle Shemilt, Valérie Porgo, Alexis F Turgeon
BACKGROUND: Injury represents one of the greatest public health challenges of our time with over 5 million deaths and 100 million people temporarily or permanently disabled every year worldwide. The effectiveness of trauma systems in decreasing injury mortality and morbidity has been well demonstrated. However, the organisation of trauma care varies significantly across trauma systems and we know little about which components of trauma systems contribute to their effectiveness. The objective of the study described in this protocol is to systematically review evidence of the impact of trauma system components on clinically significant outcomes including mortality, function and disability, quality of life, and resource utilization...
January 21, 2017: Systematic Reviews
https://www.readbyqxmd.com/read/28109269/an-appraisal-of-the-neglected-tropical-diseases-control-program-in-cameroon-the-case-of-the-national-program-against-onchocerciasis
#12
Tsi Njim, Leopold Ndemnge Aminde
BACKGROUND: Onchocerciasis is a severe parasitic infestation which causes disabling skin and subcutaneous tissue changes. Current global estimates suggest that it accounts for 1135.7 disability adjusted life years (DALYs) per 100,000 population. The disease is endemic in many African countries including Cameroon, probably suggesting that the current health policies are inadequate to achieve eradication of the disease. We aimed to appraise the current Onchocerciasis control program in Cameroon in the context of existing literature...
January 21, 2017: BMC Public Health
https://www.readbyqxmd.com/read/28109247/effectiveness-and-cost-effectiveness-of-a-guided-internet-and-mobile-based-intervention-for-the-indicated-prevention-of-major-depression-in-patients-with-chronic-back-pain-study-protocol-of-the-prod-bp-multicenter-pragmatic-rct
#13
L Sander, S Paganini, J Lin, S Schlicker, D D Ebert, C Buntrock, H Baumeister
BACKGROUND: Reducing the disease burden of major depressive disorder (MDD) is of major public health relevance. The prevention of depression is regarded as one possible approach to reach this goal. People with multiple risk factors for MDD such as chronic back pain and subthreshold depressive symptoms may benefit most from preventive measures. The Internet as intervention setting allows for scaling up preventive interventions on a public mental health level. METHODS: This study is a multicenter pragmatic randomized controlled trial (RCT) of parallel design aiming to investigate the (cost-) effectiveness of an Internet- and mobile-based intervention (IMI) for the prevention of depression in chronic back pain patients (PROD-BP) with subthreshold depressive symptoms...
January 21, 2017: BMC Psychiatry
https://www.readbyqxmd.com/read/28108850/baicalein-promotes-neuronal-and-behavioral-recovery-after-intracerebral-hemorrhage-via-suppressing-apoptosis-oxidative-stress-and-neuroinflammation
#14
Ning Wei, Yinghai Wei, Binru Li, Linlin Pang
Intracerebral hemorrhage (ICH) is an important public health problem in neurology, which is not only associated with high mortality but also leading to disability. Yet no satisfactory treatment has been developed. The secondary injury that resulted from a number of self-destructive processes such as neuroinflammation, apoptosis and oxidative stress, is the key factor contributing to ICH-induced brain damage. Baicalein has been proved to improve neuronal functional recovery in rat model of subarachnoid hemorrhage and ischemic brain damage...
January 21, 2017: Neurochemical Research
https://www.readbyqxmd.com/read/28108835/integrating-family-as-a-discipline-by-providing-parent-led-curricula-impact-on-lend-trainees-leadership-competency
#15
Bruce L Keisling, Elizabeth A Bishop, Jenness M Roth
Background While the MCH Leadership Competencies and family as a discipline have been required elements of Leadership Education in Neurodevelopmental and related Disabilities (LEND) programs for over a decade, little research has been published on the efficacy of either programmatic component in the development of the next generation of leaders who can advocate and care for Maternal and Child Health (MCH) populations. Objective To test the effectiveness of integrating the family discipline through implementation of parent led curricula on trainees' content knowledge, skills, and leadership development in family-centered care, according to the MCH Leadership Competencies...
January 20, 2017: Maternal and Child Health Journal
https://www.readbyqxmd.com/read/28108641/spinal-cord-stimulation-scs-with-anatomically-guided-3d-neural-targeting-shows-superior-chronic-axial-low-back-pain-relief-compared-to-traditional-scs-lumina-study
#16
Elias Veizi, Salim M Hayek, James North, T Brent Chafin, Thomas L Yearwood, Louis Raso, Robert Frey, Kevin Cairns, Anthony Berg, John Brendel, Nameer Haider, Matthew McCarty, Henry Vucetic, Alden Sherman, Lilly Chen, Nitzan Mekel-Bobrov
: BACKGROUND : The aim of this study was to determine whether spinal cord stimulation (SCS) using 3D neural targeting provided sustained overall and low back pain relief in a broad routine clinical practice population. STUDY DESIGN AND METHODS:  This was a multicenter, open-label observational study with an observational arm and retrospective analysis of a matched cohort. After IPG implantation, programming was done using a patient-specific, model-based algorithm to adjust for lead position (3D neural targeting) or previous generation software (traditional)...
January 20, 2017: Pain Medicine: the Official Journal of the American Academy of Pain Medicine
https://www.readbyqxmd.com/read/28108621/are-physical-measures-related-to-patient-centred-outcomes-in-ards-survivors
#17
Kitty S Chan, Lisa Aronson Friedman, Victor D Dinglas, Catherine L Hough, Carl Shanholtz, E Wesley Ely, Peter E Morris, Pedro A Mendez-Tellez, James C Jackson, Ramona O Hopkins, Dale M Needham
OBJECTIVE: To inform selection of physical measures for studies of acute respiratory distress syndrome (ARDS) survivors within 12 months of ARDS. METHODS: Secondary analysis of data from 6-month survivors participating in a US multicentre prospective study (ARDSNet Long-Term Outcome Study, N=134) or a multisite prospective study in Baltimore, Maryland, USA (Improving Care of Acute Lung Injury Patients, N=99). Physical measures, assessed at 6-month follow-up, were categorised according to the WHO's International Classification of Disability and Health: body functions and structures, activity and participation...
January 20, 2017: Thorax
https://www.readbyqxmd.com/read/28108580/chronic-conditions-and-health-care-needs-of-adolescents-born-at-23-to-25-weeks-gestation
#18
Antti Holsti, Marie Adamsson, Bruno Hägglöf, Aijaz Farooqi, Fredrik Serenius
OBJECTIVE: We examined chronic conditions, functional limitations, and special health care needs in extremely preterm children (EPT; 23-25 weeks' gestation) born between 1992 and 1998 at 2 Swedish tertiary care centers that offered regional and active perinatal care to all live-born EPT infants. METHODS: Of 134 surviving EPT children, 132 (98%) were assessed at 10 to 15 years of age alongside 103 term-born controls. Identification of children with functional limitations and special health care needs was based on a questionnaire administered to parents...
January 20, 2017: Pediatrics
https://www.readbyqxmd.com/read/28108546/automatic-health-record-review-to-help-prioritize-gravely-ill-social-security-disability-applicants
#19
Kenneth Abbott, Yen-Yi Ho, Jennifer Erickson
OBJECTIVE: Every year, thousands of patients die waiting for disability benefits from the Social Security Administration. Some qualify for expedited service under the Compassionate Allowance (CAL) initiative, but CAL software focuses exclusively on information from a single form field. This paper describes the development of a supplemental process for identifying some overlooked but gravely ill applicants, through automatic annotation of health records accompanying new claims. We explore improved prioritization instead of fully autonomous claims approval...
January 20, 2017: Journal of the American Medical Informatics Association: JAMIA
https://www.readbyqxmd.com/read/28108505/comparative-transcriptomics-of-buzura-suppressaria-lepidoptera-geometridae-assembled-de-novo-yield-insights-into-response-after-buzura-suppressaria-nuclear-polyhedrosis-virus-infection
#20
Ji Luo, Yating Zhong, Jiyu Zhu, Guoying Zhou, Huayan Huang, Yaojun Wu
Buzura suppressaria Guenee (Lepidoptera: Geometridae) is a defoliator that seriously harms eucalyptus trees in South China. Buzura suppressaria nuclear polyhedrosis virus (BsNPV) is a baculovirus that infects B. suppressaria with high specificity and efficiency. Transcriptomes of B. suppressaria were sequenced before and after BsNPV infection using an Illumina-based platform to probe for differentially expressed genes (DEGs) of B. suppressaria after viral infection. On average, ∼57.4 million high-quality clean reads were generated and assembled de novo into 69,761 unigenes...
January 20, 2017: Journal of Economic Entomology
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