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https://www.readbyqxmd.com/read/29156871/relationship-of-spinal-curvature-mobility-and-low-back-pain-in-women-with-and-without-urinary-incontinence
#1
Şeyda Toprak Çelenay, Derya Özer Kaya
Background/aim: This study aimed to investigate the relationship of sagittal spinal curvature, mobility, and low back pain (LBP) in women with and without urinary incontinence (UI). Materials and methods: Thirty-two women with UI (incontinence group) and 41 women without UI (control group) were included in this study. The sagittal spinal curvature and mobility were assessed with a Spinal Mouse device (IDIAG, Fehraltorf, Switzerland). Urogenital symptom distress, LBP, and disability caused by LBP were assessed using the Urogenital Distress Inventory-6 (UDI-6), a visual analog scale (VAS), and the Oswestry Disability Index (ODI), respectively...
August 23, 2017: Turkish Journal of Medical Sciences
https://www.readbyqxmd.com/read/29156638/development-of-evidence-based-disease-education-literature-for-pakistani-rheumatoid-arthritis-patients
#2
Atta Abbas Naqvi, Mohamed Azmi Hassali, Muhammad Tariq Aftab, Syed Baqir Shyum Naqvi, Fatima Zehra, Rizwan Ahmad, Niyaz Ahmad
Rheumatoid arthritis affects 0.5% to 1% of the population globally and is one of the most common causes of disability. Patient education plays a key role in improving treatment outcomes. The purpose of this study was to discuss the process involved in designing an evidence-based disease education literature for rheumatoid arthritis patients of Pakistan in Urdu language with culturally relevant illustrations. A study was conducted to develop disease education literature using Delphi consensus, content validity, and patient feedback...
November 20, 2017: Diseases (Basel)
https://www.readbyqxmd.com/read/29156480/-frailty-prevalence-in-the-resident-population-of-germany-70%C3%A2-%C3%A2-79-years-of-age-a-population-based-approach
#3
Judith Fuchs, Markus Busch, Christa Scheidt-Nave
In all countries life expectancy is rising, and many older persons spend a longer period in good health. Nevertheless, frailty is present in older people and can be considered as a risk factor for limitations. The "German Health Interview and Examination Survey for Adults" (DEGS1) 2008 - 2011 comprised interviews, examinations and tests. Data on 1110 community-dwelling people aged 70 to 79 years participating in DEGS1 with full records on frailty were analysed. Physical frailty was defined as exhaustion (SF-36 item), low grip strength, slowness (Timed Up-and-Go test > 15 seconds or unable to perform) and low physical activity (no sports or exertion)...
November 2017: Anästhesiologie, Intensivmedizin, Notfallmedizin, Schmerztherapie: AINS
https://www.readbyqxmd.com/read/29156426/theory-of-mind-and-schizophrenia-in-young-and-middle-aged-patients-influence-of-executive-functions
#4
Marta Croca, Aurèlie Lagodka, Remi Gadel, Marie Chantal Bourdel, Narjes Bendjemaa, Raphael Gaillard, Jean Pierre Olié, M Champagne-Lavau, Marie Odile Krebs, Isabelle Amado
Theory of Mind (ToM) is compromised in schizophrenia, and responsible for social disability. We aim to study the correlation between ToM deficits and Executive Functions (EF), using the Faux Pas Test (FPT) for ToM evaluation, Behavioral Assessment of the Dysexecutive Syndrome (BADS) and Wisconsin Card Sorting Test (WCST) for EF assessment. Two groups of patients with schizophrenia were included: 22 young (18-35 years-old) and 18 middle-aged (>50 years-old) Patients, compared to age-matched Controls. We found worst FPT performances in both groups of patients, but with a more generalized pattern of dysfunction in the middle-aged patient group...
November 17, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/29156296/associations-between-severity-of-anxiety-and-clinical-and-biological-features-of-major-affective-disorders
#5
Fernanda Liboni Cavicchioli, Michael Maes, Chutima Roomruangwong, Kamila Landucci Bonifacio, Decio Sabbatini Barbosa, George Anderson, Heber Odebrecht Vargas, Sandra Odebrecht Vargas Nunes
Patients with major affective disorders (MAFD) with comorbid anxiety show a greater functional impairment than those without anxiety. The aim of this study is to delineate the associations between severity of anxiety in MAFD, namely bipolar disorder (BD) and major depression (MDD), and MAFD characteristics and serum high-density lipoprotein (HDL)-cholesterol levels. Recruited were 82 participants with anxiety disoders and 83 without anxiety disoders, including 101 MAFD patients and 51 healthy controls. We used the Hamilton Anxiety Rating Scale (HAM-A) to measure severity of anxiety and made the diagnoses of posttraumatic stress disorder (PTSD), obsessive compulsive disorder (OCD), panic disorder (PD), generalized anxiety disorder (GAD) and phobias...
November 8, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/29156220/the-epilepsy-phenotype-in-adult-patients-with-intellectual-disability-and-pathogenic-copy-number-variants
#6
Giuseppe d'Orsi, Tommaso Martino, Orazio Palumbo, Maria Grazia Pascarella, Pietro Palumbo, Maria Teresa Di Claudio, Carlo Avolio, Massimo Carella
PURPOSE: To characterize the electroclinical features of epilepsy associated with intellectual disability and pathogenic copy number variations (CNVs) METHODS: we prospectively investigated 61 adult patients with epilepsy and intellectual disability or other neurodevelopmental disorders. We performed high resolution SNP-Array analysis in order to detect clinical relevant chromosomal microdeletions and microduplications. An ordinal logistic regression model was fitted with 34 demographic, clinical and EEG-related variables in order to identify the epilepsy phenotype of patients with pathogenic CNVs...
November 14, 2017: Seizure: the Journal of the British Epilepsy Association
https://www.readbyqxmd.com/read/29156166/allograft-bone-what-is-the-role-of-platelet-derived-growth-factor-in-hindfoot-and-ankle-fusions
#7
REVIEW
Ryan T Scott, Jeffrey E McAlister, Ryan B Rigby
Arthrodesis of the ankle or foot is a common procedure for chronic pain and disability. Nonunion remains a prevalent complication among arthrodesis procedures. Some patients present with an inherent risk of developing a nonunion. Allograft biologics have gained popularity in an effort to reduce complications such as nonunion. Various biologics bring unique properties while maintaining a singular purpose. Platelet-derived growth factor (PDGF) may be introduced into a fusion site to facilitate healthy bony consolidation...
January 2018: Clinics in Podiatric Medicine and Surgery
https://www.readbyqxmd.com/read/29155948/predictors-of-fatigue-and-work-ability-in-cancer-survivors
#8
P van Muijen, S F A Duijts, K Bonefaas-Groenewoud, A J van der Beek, J R Anema
Background: Workers diagnosed with cancer are at risk for job loss or work disability. Aims: To determine predictors of fatigue and work ability at 36 months after diagnosis in a population of cancer survivors. Methods: Individuals diagnosed with cancer and who applied for work disability benefit at 24 months of sick leave were surveyed at the time of application and again 12 months later. Fatigue was measured using the Functional Assessment of Chronic Illness-Fatigue scale questionnaire and work ability was measured using the work ability index...
November 16, 2017: Occupational Medicine
https://www.readbyqxmd.com/read/29155853/novel-chloroacetamido-compound-cwr-j02-is-an-anti-inflammatory-glutaredoxin-1-inhibitor
#9
Olga Gorelenkova Miller, Kyle S Cole, Corey C Emerson, Dharmaraja Allimuthu, Marcin Golczak, Phoebe L Stewart, Eranthie Weerapana, Drew J Adams, John J Mieyal
Glutaredoxin (Grx1) is a ubiquitously expressed thiol-disulfide oxidoreductase that specifically catalyzes reduction of S-glutathionylated substrates. Grx1 is known to be a key regulator of pro-inflammatory signaling, and Grx1 silencing inhibits inflammation in inflammatory disease models. Therefore, we anticipate that inhibition of Grx1 could be an anti-inflammatory therapeutic strategy. We used a rapid screening approach to test 504 novel electrophilic compounds for inhibition of Grx1, which has a highly reactive active-site cysteine residue (pKa 3...
2017: PloS One
https://www.readbyqxmd.com/read/29155821/progress-towards-a-leprosy-free-country-the-experience-of-oman
#10
Salah T Al Awaidy
INTRODUCTION: The World Health Organization (WHO) released the Global Leprosy Strategy 2016-2020 towards a leprosy-free world. The author described the progress made towards the elimination of leprosy and suggested recommendations for the acceleration towards a Leprosy-free country according to WHO laid out criterion. METHODOLOGY: Case record review of Leprosy patients managed between the years 1992 to 2015 were registered and analyzed. Data were collected from annual reports of the Ministry of Health including demographics, classification of leprosy new cases, relapse, childhood, grades of disability (GD) and multidrug therapy (MDT) completion rates...
November 20, 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/29155655/synergies-between-communicable-and-noncommunicable-disease-programs-to-enhance-global-health-security
#11
Deliana Kostova, Muhammad J Husain, David Sugerman, Yuling Hong, Mona Saraiya, Jennifer Keltz, Samira Asma
Noncommunicable diseases are the leading cause of death and disability worldwide. Initiatives that advance the prevention and control of noncommunicable diseases support the goals of global health security in several ways. First, in addressing health needs that typically require long-term care, these programs can strengthen health delivery and health monitoring systems, which can serve as necessary platforms for emergency preparedness in low-resource environments. Second, by improving population health, the programs might help to reduce susceptibility to infectious outbreaks...
December 2017: Emerging Infectious Diseases
https://www.readbyqxmd.com/read/29155343/health-outcomes-and-costs-of-acute-traumatic-spinal-injury-in-new-south-wales-australia
#12
Rebecca Mitchell, Lara Harvey, Ralph Stanford, Jacqueline Close
BACKGROUND CONTEXT: Traumatic spinal injuries are often associated with both long-term disability, higher frequency of hospital readmissions and high medical costs for individuals of all ages. Age differences in terms of injury profile and health outcomes among those who sustain a spinal cord injury have been identified. However, factors that may influence health outcomes among those with a spinal injury have not been extensively examined at a population-level. PURPOSE: To describe the characteristics of traumatic spinal injury, identify factors predictive of mortality; and estimate the cost of hospital treatment for younger and older people...
November 16, 2017: Spine Journal: Official Journal of the North American Spine Society
https://www.readbyqxmd.com/read/29155288/investigation-of-the-practices-legislation-supply-chain-and-regulation-of-opioids-for-clinical-pain-management-in-southern-africa-a-multi-sectoral-cross-national-mixed-methods-study
#13
Eve Namisango, Matthew J Allsop, Richard A Powell, Stefan J Friedrichsdorf, Emmanuel Bk Luyirika, Fatia Kiyange, Edward Mukooza, Chris Ntege, Eunice Garanganga, Mavis Ntombifuthi Ginindza-Mdluli, Faith Mwangi-Powell, Lidia Justino Mondlane, Richard Harding
CONTEXT: Sub-Saharan Africa faces an increasing incidence and prevalence of life-limiting and life-threatening conditions. These conditions are associated with a significant burden of pain linked to high morbidity and disability that is poorly assessed and undertreated. Barriers to effective pain management partly relate to lack of access to opioid analgesia and challenges in their administration. OBJECTIVES: To identify country-specific and broader regional barriers to access, as well as the administration of opioids, and generate recommendations for advancing pain management in Southern Africa...
November 15, 2017: Journal of Pain and Symptom Management
https://www.readbyqxmd.com/read/29155152/higher-prevalence-and-earlier-appearance-of-geriatric-phenotypes-in-old-adults-with-type-2-diabetes-mellitus
#14
Marina Kotsani, Thekla Chatziadamidou, Dimitrios Economides, Athanase Benetos
AIMS: To compare the prevalence of cognitive dysfunction, depression, lower mobility performance, disability and falls in older community-dwelling individuals with type 2 diabetes mellitus (T2DM) and in controls of similar age. METHODS: We conducted a cross-sectional study in primary health care settings in 3 semi-urban regions in Greece. Were assessed 403 community-dwelling older persons (age ≥65years, median: 73), 198 with and 205 without diabetes. Common geriatric syndromes were studied using structured individual interviews and widely-used screening scales...
November 16, 2017: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/29155111/surgical-treatment-of-spinal-synovial-cysts-in-the-elderly-symptoms-treatment-course-and-outcome-in-patients-over-75-years
#15
Markus Bruder, Florian Gessler, Adriano Cattani, Christian Droste, Volker Seifert, Matthias Setzer, Gerhard Marquardt
OBJECTIVE: The ongoing aging of our society leads to a rising number of elderly patients with progressive degeneration of the spine, associated with synovial cysts. In the elderly, surgical treatment may be particularly challenging because of comorbidities. METHODS: Patients treated in our department between 1999 and 2014 for spinal synovial cysts were screened. The 28 patients aged 75 years and older were classified as "elderly". Those were compared with 96 patients between 50 and 74 years...
November 15, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/29155010/intra-amoebal-killing-of-mycobacterium-ulcerans-by-acanthamoeba-griffini-a-co-culture-model
#16
Amar Bouam, Eric Ghigo, Michel Drancourt
Mycobacterium ulcerans, a decaying Mycobacterium marinum derivative is responsible for Buruli ulcer, a notifiable non-contagious disabling infection highly prevalent in some West African countries. Aquatic environments are suspected to host M. ulcerans, however, the exact reservoirs remain unknown. While M. marinum was found to resist amoebal microbicidal activities, this remains unknown for M. ulcerans. In this study M. ulcerans was co-cultured with the moderately halophile Acanthamoeba griffini at 30 °C to probe this tropical amoeba as a potential reservoir for M...
November 17, 2017: Microbial Pathogenesis
https://www.readbyqxmd.com/read/29154811/a-systematic-review-highlights-the-need-to-investigate-the-content-validity-of-patient-reported-outcome-measures-for-physical-functioning-in-low-back-pain
#17
REVIEW
Alessandro Chiarotto, Raymond W Ostelo, Maarten Boers, Caroline B Terwee
OBJECTIVE: To summarize the evidence on content and structural validity of 17 patient-reported outcome measures (PROMs) to measure physical functioning in LBP. STUDY DESIGN AND SETTING: MEDLINE, EMBASE, CINAHL, PsycINFO, SportDiscus, and Google Scholar were searched (February 2017). Records on development, and studies assessing content validity or unidimensionality in patients with LBP were included. Two reviewers defined eligible studies and assessed their methodological quality with updated COSMIN standards...
November 14, 2017: Journal of Clinical Epidemiology
https://www.readbyqxmd.com/read/29154721/validating-the-use-of-brain-volume-cutoffs-to-identify-clinically-relevant-atrophy-in-rrms
#18
Francesca Bovis, Nicola De Stefano, Joshua R Steinerman, Volker Knappertz, Maria Pia Sormani
BACKGROUND: Baseline brain volume (BV) is predictive at a group level but is difficult to interpret at the single patient level. OBJECTIVE: To validate BV cutoffs able to identify clinically relevant atrophy in relapsing-remitting multiple sclerosis (RRMS) patients. METHODS: The expected normalized brain volume (NBV) for each patient was calculated using RRMS patients from two phase III clinical trials, applying a linear formula developed on the baseline variable of an independent data set...
November 1, 2017: Multiple Sclerosis: Clinical and Laboratory Research
https://www.readbyqxmd.com/read/29154697/rate-of-subtalar-joint-arthrodesis-after-retrograde-tibiotalocalcaneal-arthrodesis-with-intramedullary-nail-fixation-evaluation-of-the-rain-database
#19
Michael Dujela, Christopher F Hyer, Gregory C Berlet
BACKGROUND: Hindfoot arthritis or significant deformity involving the ankle and subtalar joint (STJ) is a disabling condition with few salvage options. Many surgeons note a decreased STJ fusion rate compared with ankle union when a retrograde nail construct is used. The purpose of this study was to report the STJ fusion rate of tibiotalocalcaneal (TTC) arthrodesis with retrograde nail. METHODS: A chart and radiographic review was performed. TTC fusions performed in patients with osteoarthritis, posttraumatic arthritis, or deformity correction with retrograde nail fixation were included...
November 1, 2017: Foot & Ankle Specialist
https://www.readbyqxmd.com/read/29154606/dyadic-effects-of-depressive-symptoms-on-medical-morbidity-in-middle-aged-and-older-couples
#20
Courtney A Polenick, Brenna N Renn, Kira S Birditt
OBJECTIVE: Depressive symptoms in middle and later life are associated with an increased risk of greater medical morbidity (i.e., number of chronic health conditions). Yet little is known about mutual influences that may occur within married couples. This study examined the effects of wives' and husbands' depressive symptoms on their own and their partner's number of chronic health conditions over an 8-year period. It was also determined whether these effects varied by gender. METHOD: The U...
November 20, 2017: Health Psychology: Official Journal of the Division of Health Psychology, American Psychological Association
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