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https://www.readbyqxmd.com/read/28288165/neutropenia-induced-by-high-dose-intravenous-benzylpenicillin-in-treating-neurosyphilis-does-it-really-matter
#1
Rui-Rui Peng, Juan Wu, Wei Zhao, Tengfei Qi, Mei Shi, Zhifang Guan, Haikong Lu, Fuquan Long, Zixiao Gao, Sufang Zhang, Pingyu Zhou
BACKGROUND: Prompt therapy with high-dose intravenous benzylpenicillin for a prolonged period is critical for neurosyphilis patients to avoid irreversible sequelae. However, life-threatening neutropenia has been reported as a complication of prolonged therapy with high doses of benzylpenicillin when treating other diseases. This study aimed to investigate the incidence, presentation, management and prognosis of benzylpenicillin-induced neutropenia in treating neurosyphilis based on a large sample of syphilis patients in Shanghai...
March 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28243433/a-rare-case-of-fusobacterium-necrophorum-liver-abscesses
#2
Faris Hannoodi, Hussam Sabbagh, Zain Kulairi, Sarwan Kumar
Liver abscesses are an uncommon disease that can present with vague symptoms. Fusobacterium necrophorum causing liver abscesses is a rare condition and only a few cases have been reported. An 88-year-old female presented to her primary care physician with one week of fevers, night sweats, chills, fatigue and vague right upper quadrant abdominal pain. She denied nausea, vomiting, constipation, diarrhea and unintentional weight loss. A computed tomography scan of the abdomen showed two liver abscesses in the right lobe as well as extensive diverticulosis...
January 11, 2017: Clinics and Practice
https://www.readbyqxmd.com/read/28191374/klebsiella-pneumoniae-liver-abscess-a-case-report-and-review-of-literature
#3
Faisal Kamal, George Williams, Hina Akbar, Muhammad Ali Khan, Dipen Kadaria
Klebsiella pneumoniae (K.pneumoniae) is a known cause of pyogenic liver abscess (PLA) in the absence of hepatobiliary disease. In settings of hepatic infection, it has also been known to cause disseminated infections including meningitis and endopthalmitis. Several groups of patients are particularly susceptible to infection, including patients with diabetes mellitus, those from Southeast Asia and those with the preexisting hepatobiliary disease. We present a case of K.pneumoniae PLA with bacteremia. A 39-year-old Vietnamese male with no previous medical history who presented with complaints of abdominal pain, nausea, vomiting, diarrhea and fever...
January 10, 2017: Curēus
https://www.readbyqxmd.com/read/28178108/a-hospital-based-case-control-study-of-diarrhea-in-children-in-shanghai
#4
Hailing Chang, Ling Zhang, Yanling Ge, Jiehao Cai, Xiangshi Wang, Zheng Huang, Jiayin Guo, Hao Xu, Zhen Gu, Hong Chen, Xuebin Xu, Mei Zeng
BACKGROUND: Prevention and control of childhood diarrhea is a global priority. We conducted a case-control study of childhood diarrhea in Shanghai. METHODS: We prospectively recruited diarrheal children in an outpatient setting. Non-diarrheal controls were individually matched to cases. Rotavirus, norovirus and bacterial pathogens were examined. Clinical and epidemiologic data were obtained at enrollment and follow-up. RESULTS: Potential pathogens identified in 680 diarrheal cases and 680 controls were rotavirus (19...
February 6, 2017: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/28149516/salmonella-enteritidis-primary-bacteremia-in-previously-healthy-patient-from-taiwan-case-report
#5
Sevda Mileva, Margarita Gospodinova, Ilian Todorov
BACKGROUND: Diseases caused by invasive nontyphoidal Salmonella strains present with various extraintestinal manifestations, including bacteremia. Factors affecting the incidence include Salmonella serotype, geographic location, and host factors. CASE: We present an unusual case of Salmonella enteritidis primary bacteremia in a patient without any risk factors and originating from a region with the lowest burden of invasive nontyphoidal Salmonella infections. We observed an incomplete clinical response to the treatment with a third-generation cephalosporin, despite the in vitro susceptibility of the strain...
October 2016: Therapeutic Advances in Infectious Disease
https://www.readbyqxmd.com/read/28056940/a-large-and-persistent-outbreak-of-typhoid-fever-caused-by-consuming-contaminated-water-and-street-vended-beverages-kampala-uganda-january-june-2015
#6
Steven Ndugwa Kabwama, Lilian Bulage, Fred Nsubuga, Gerald Pande, David Were Oguttu, Richardson Mafigiri, Christine Kihembo, Benon Kwesiga, Ben Masiira, Allen Eva Okullo, Henry Kajumbula, Joseph Matovu, Issa Makumbi, Milton Wetaka, Sam Kasozi, Simon Kyazze, Melissa Dahlke, Peter Hughes, Juliet Nsimire Sendagala, Monica Musenero, Immaculate Nabukenya, Vincent R Hill, Eric Mintz, Janell Routh, Gerardo Gómez, Amelia Bicknese, Bao-Ping Zhu
BACKGROUND: On 6 February 2015, Kampala city authorities alerted the Ugandan Ministry of Health of a "strange disease" that killed one person and sickened dozens. We conducted an epidemiologic investigation to identify the nature of the disease, mode of transmission, and risk factors to inform timely and effective control measures. METHODS: We defined a suspected case as onset of fever (≥37.5 °C) for more than 3 days with abdominal pain, headache, negative malaria test or failed anti-malaria treatment, and at least 2 of the following: diarrhea, nausea or vomiting, constipation, fatigue...
January 5, 2017: BMC Public Health
https://www.readbyqxmd.com/read/28052855/the-oral-%C3%AE-lactamase-syn-004-ribaxamase-degrades-ceftriaxone-excreted-into-the-intestine-in-phase-2a-clinical-studies
#7
John F Kokai-Kun, Tracey Roberts, Olivia Coughlin, Eric Sicard, Marianne Rufiange, Richard Fedorak, Christian Carter, Marijke H Adams, James Longstreth, Heidi Whalen, Joseph Sliman
SYN-004 (ribaxamase) is a β-lactamase designed to be orally administered concurrently with intravenous β-lactam antibiotics, including most penicillins and cephalosporins. Ribaxamase's anticipated mechanism of action is to degrade excess β-lactam antibiotic that is excreted into the small intestine. This enzymatic inactivation of excreted antibiotic is expected to protect the gut microbiome from disruption and thus prevent undesirable side effects, including secondary infections such as Clostridium difficile infections, as well as other antibiotic-associated diarrheas...
March 2017: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/27920655/deep-vein-thrombosis-as-initial-manifestation-of-whipple-disease
#8
Mônica Souza de Miranda Henriques, Alexandre Rolim da Paz, Ana Beatriz Person Gaertner, Cibelle Ingrid Stephen Melo, Priscyanne Lins Filgueiras, Rafaella Alencar Jerome
INTRODUCTION: Wipple disease (WD) is a rare chronic disease caused by the bacillus Tropheryma whipplei. Constitutive, rheumatologic, gastrointestinal, cardiac, cerebral, lymphatic, cutaneous, and ophthalmological signs are possible systemic symptoms. However, thrombotic manifestations are rarely described as "stroke-like syndrome" or arterial thrombosis. Diagnosis is based on clinical manifestations and pathological examination. Laboratory findings may include anemia, leukocytosis, and thrombocytosis...
September 2016: Case Reports in Gastroenterology
https://www.readbyqxmd.com/read/27829601/whipple-s-disease-diagnosed-using-electron-microscopy-and-polymerase-chain-reaction
#9
REVIEW
Tomohiro Nagasue, Koichi Kurahara, Hiroki Yaita, Takahide Tanaka, Yumi Oshiro, Nobuaki Kuno, Akira Harada, Masashi Kameda, Kazuhide Iwasaki, Yutaka Tsutsumi
A 50-year-old man presented with bloody diarrhea and 25-kg weight loss over 3 months. Upper and lower endoscopy showed diffuse shaggy white villi in the duodenum and terminal ileum. In addition, capsule endoscopy and double-balloon enteroscopy revealed shaggy white villi in the entire small intestine. Histological examination of biopsy specimens found the lamina propria of the duodenal and intestinal mucosa to be densely infiltrated by rich foamy macrophages that were periodic acid-Schiff-positive. Electron microscopy showed numerous bacilli in the lamina propria...
2016: Nihon Shokakibyo Gakkai Zasshi, the Japanese Journal of Gastro-enterology
https://www.readbyqxmd.com/read/27766094/the-first-report-of-a-fully-sequenced-resistance-plasmid-from-shigella-boydii
#10
Li Wang, Lei Liu, Dong Liu, Zhe Yin, Jiao Feng, Defu Zhang, Haihong Fang, Yefeng Qiu, Weijun Chen, Ruisheng Yang, Jinglin Wang, Yunzhi Fa, Dongsheng Zhou
The purpose of this study was to characterize mechanisms of plasmid-mediated antimicrobial resistance in Shigella boydii. S. boydii strain 2246 with resistance to ciprofloxacin, ceftriaxone and azithromycin was isolated from a human case of watery diarrhea in a Chinese public hospital. Resistance in strain 2246 to ceftriaxone and azithromycin was attributable to the presence of blaCTX-M-14, and erm(B) and mph(A), respectively, which were co-located on a multidrug-resistant (MDR) plasmid p2246-CTXM. p2246-CTXM represented a novel IncFII-type MDR plasmid with a very complex chimera structure...
2016: Frontiers in Microbiology
https://www.readbyqxmd.com/read/27580337/diarrhea-associated-pneumococcal-meningitis-with-complicating-hydrocephalus-in-a-child-in-a-resource-limited-setting
#11
Lubaba Shahrin, Mohammod Jobayer Chisti, Sayeeda Huq, Md Munirul Islam, Shafiqul Alam Sarker, Mahmuda Begum, Shukla Saha, Tahmeed Ahmed
INTRODUCTION: Streptococcus pneumonia is the most common and intimidating cause of childhood meningitis. Its delayed diagnosis may be associated with hyponatremia and hypernatremia with fatal outcome. CASE PRESENTATION: A previously healthy nine-month-old Bangladeshi female infant was diagnosed with diarrhea, pneumonia, and convulsion due to hypernatremia. Pneumonia was confirmed by respiratory distress and radiological findings. Routine cerebrospinal fluid study detected pneumococcal meningitis...
August 31, 2016: Journal of Infection in Developing Countries
https://www.readbyqxmd.com/read/27525402/-a-sepsis-case-caused-by-a-rare-opportunistic-pathogen-bacillus-pumilus
#12
Barış Ata Borsa, Mehmet Ersoy Aldağ, Birsen Tunalı, Uğur Dinç, Zeynep Güngördü Dalar, Veli Cengiz Özalp
The high prevalence of Bacillus species in nature and the detection of these bacteria as contaminant in cultures may lead diagnostic dilemma, however they should still be considered as a pathogen particularly in case of repeated positive cultures from patients with risk factors. Bacillus pumilus is a bacteria, though rarely, been reported as the causative agent of various infections such as sepsis, endocarditis, skin infections and food poisoning in human. In this report, a sepsis case in an immunocompetent patient caused by B...
July 2016: Mikrobiyoloji Bülteni
https://www.readbyqxmd.com/read/27503019/viral-and-bacterial-etiology-of-acute-diarrhea-among-children-under-5-years-of-age-in-wuhan-china
#13
Xu-Hui Zhu, Lei Tian, Zhong-Ju Cheng, Wei-Yong Liu, Song Li, Wei-Ting Yu, Wen-Qian Zhang, Xu Xiang, Zi-Yong Sun
BACKGROUND: Acute diarrhea remains the serious problem in developing countries, especially among children under 5 years of age. Currently, only two or three common diarrhea pathogens were screened at most hospitals in China. The aim of this study was to provide a wide variety of diarrhea pathogens and their antimicrobial resistance patterns in children under 5 years of age. METHODS: Totally 381 stool samples collected from Tongji Hospital between July 1, 2014 and June 30, 2015 were tested by culture and/or polymerase chain reaction for eight kinds of bacteria and five kinds of viruses...
August 20, 2016: Chinese Medical Journal
https://www.readbyqxmd.com/read/27025738/clinical-efficacy-of-a-single-two-gram-dose-of-azithromycin-extended-release-for-male-patients-with-urethritis
#14
Satoshi Takahashi, Hiroshi Kiyota, Shin Ito, Akihiko Iwasawa, Yoshiki Hiyama, Teruhisa Uehara, Koji Ichihara, Jiro Hashimoto, Naoya Masumori, Kenichi Sunaoshi, Koichi Takeda, Nobukazu Suzuki, Takahide Hosobe, Hirokazu Goto, Hidenori Suzuki, Shoichi Onodera
To clarify the clinical efficacy of a single oral 2 g dose of azithromycin extended-release for heterosexual male patients with urethritis, and the current antimicrobial sensitivity of Neisseria gonorrhoeae to azithromycin, a prospective clinical trial was conducted from 2011-2013. In patients with gonococcal urethritis, the eradication rate was 90.9% (30 of 33). The susceptibility rates of isolated Neisseria gonorrhoeae strains to ceftriaxone, spectinomycin, cefixime and azithromycin were 100%, 100%, 95.3% (41/43) and 37...
2014: Antibiotics
https://www.readbyqxmd.com/read/26700136/nonclinical-safety-assessment-of-syn-004-an-oral-%C3%AE-lactamase-for-the-protection-of-the-gut-microbiome-from-disruption-by-biliary-excreted-intravenously-administered-antibiotics
#15
John F Kokai-Kun, J Andrew Bristol, John Setser, Michael Schlosser
SYN-004 is a first in class, recombinant β-lactamase that degrades β-lactam antibiotics and has been formulated to be administered orally to patients receiving intravenous β-lactam antibiotics including cephalosporins. SYN-004 is intended to degrade unmetabolized antibiotics excreted into the intestines and thus has the potential to protect the gut microbiome from disruption by these antibiotics. Protection of the gut microbiome is expected to protect against opportunistic enteric infections such as Clostridium difficile infection as well as antibiotic-associated diarrhea...
May 2016: International Journal of Toxicology
https://www.readbyqxmd.com/read/26674319/characteristics-of-bacterial-acute-diarrhea-among-women
#16
Juliane Rocha-Castro, Karoline Kronbauer, Jessica Dallé, Mirela F Jimenez, Cezar W Riche, Jorge A Santiago, Vicente S Antonello
OBJECTIVE: To describe the clinical and microbiological characteristics of women presenting with acute gastroenteritis due to infection with Salmonella spp. or Shigella spp. METHODS: A cross-sectional retrospective study was conducted using data for patients with specimens positive for Shigella spp. and Salmonella spp. attending two major women's hospitals in Porto Alegre, Brazil, between January 2003 and July 2014. Women were included if they had symptoms compatible with bacterial acute diarrhea...
March 2016: International Journal of Gynaecology and Obstetrics
https://www.readbyqxmd.com/read/26649803/short-article-relapsing-whipple-s-disease-a-case-report-and-literature-review
#17
REVIEW
Elena Ruggiero, Anna Zurlo, Valter Giantin, Francesca Galeazzi, Claudia Mescoli, Giovanni Nante, Florinda Petruzzellis, Enzo Manzato
Whipple's disease is a rare infection caused by Tropheryma whipplei, a Gram-negative Bacillus usually found in macrophages of the lamina propria of the small intestine. The typical clinical manifestations of classic Whipple's disease are diarrhea, weight loss, malabsorption, abdominal pain, and arthralgia. The disease's laboratory diagnosis is currently based on duodenal biopsy. Treatment generally includes primary therapy for 2 weeks with intravenous antibiotics capable of reaching high levels in the cerebrospinal fluid, such as ceftriaxone, usually followed by treatment with oral cotrimoxazole for 1 year...
March 2016: European Journal of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/26566453/shiga-toxigenic-escherichia-coli-in-iranian-pediatric-patients-with-and-without-diarrhea-o-serogroups-virulence-factors-and-antimicrobial-resistance-properties
#18
Banafshe Dormanesh, Soheila Siroosbakhat, Peyman Karimi Goudarzi, Ladan Afsharkhas
BACKGROUND: Shiga-toxigenic Escherichia coli is an important human pathogen cause of diarrhea, hemorrhagic colitis, hemolytic uremic syndrome and thrombotic thrombocytopenic purpura in humans is a significant public health. OBJECTIVES: The aim of this study was to determine the molecular characteristics and antimicrobial resistance properties of Shiga toxigenic Escherichia coli (STEC) strains with respect to their seasonal, age and geographical distributions in Iranian pediatric patients with and without diarrhea...
October 2015: Iranian Red Crescent Medical Journal
https://www.readbyqxmd.com/read/26552136/-a-case-of-acute-respiratory-distress-syndrome-ards-accompanied-with-influenza-h1n1-2009-successfully-treated-with-polymyxin-b-immobilized-fiber-column-direct-hemoperfusion-pmx-dhp
#19
Mayuri Nakano, Seiji Yoshida, Tadashi Nakayama, Fumitaka Ogushi, Masaki Hanibuchi, Yasuhiko Nishioka
A 51-year-old man was admitted to our hospital because of fever and diarrhea. Chest X-ray revealed consolidation in the left lower lung field. Ceftriaxone and minocycline were given empirically, under the suspicion of bacterial or atypical pneumonia. In spite of treatment with antibiotics, the disease rapidly progressed to systemic inflammatory response syndrome. The diagnosis of acute respiratory distress syndrome (ARDS) accompanied with influenza (H1N1) 2009 was made because of positive findings of real-time polymerase chain reaction...
May 2015: Kansenshōgaku Zasshi. the Journal of the Japanese Association for Infectious Diseases
https://www.readbyqxmd.com/read/26467000/severe-septicemia-necrotizing-fasciitis-and-peritonitis-due-to-vibrio-vulnificus-in-a-patient-undergoing-continuous-ambulatory-peritoneal-dialysis-a-case-report
#20
Chang Seong Kim, Eun Hui Bae, Seong Kwon Ma, Soo Wan Kim
BACKGROUND: Chronic kidney disease, including end-stage renal disease, has been identified as a possible risk factor for primary septicemia and wound infection by Vibrio vulnificus. However, cases of severe septicemia, necrotizing fasciitis, and peritonitis caused by V. vulnificus in patients undergoing continuous ambulatory peritoneal dialysis (CAPD) have not been described. We report a case of severe septicemia, necrotizing fasciitis, and peritonitis due to V. vulnificus in a patient undergoing CAPD after ingesting raw seafood...
October 14, 2015: BMC Infectious Diseases
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