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Bruna Macangnin Seimetz, Adriane Ribeiro Teixeira, Leticia Petersen Schmidt Rosito, Leticia Sousa Flores, Carlos Henrique Pappen, Celso Dall'igna
Introduction Tinnitus is a symptom that is often associated with presbycusis. Objective This study aims to analyze the existence of association among hearing thresholds, pitch, and loudness of tinnitus in individuals with presbycusis, considering the gender variable. Methods Cross-sectional, descriptive, and prospective study, whose sample consisted of individuals with tinnitus and diagnosis of presbycusis. For the evaluation, we performed anamnesis along with otoscopy, pure tone audiometry, and acuphenometry to analyze the psychoacoustic characteristics of tinnitus individuals...
October 2016: International Archives of Otorhinolaryngology
Robert D Frisina, Bo Ding, Xiaoxia Zhu, Joseph P Walton
Age-related hearing loss (ARHL) -presbycusis - is the most prevalent neurodegenerative disease and number one communication disorder of our aged population; and affects hundreds of millions of people worldwide. Its prevalence is close to that of cardiovascular disease and arthritis, and can be a precursor to dementia. The auditory perceptual dysfunction is well understood, but knowledge of the biological bases of ARHL is still somewhat lacking. Surprisingly, there are no FDA-approved drugs for treatment. Based on our previous studies of human subjects, where we discovered relations between serum aldosterone levels and the severity of ARHL, we treated middle age mice with aldosterone, which normally declines with age in all mammals...
September 23, 2016: Aging
Tao Xue, Li Wei, Ding-Jun Zha, Jian-Hua Qiu, Fu-Quan Chen, Li Qiao, Yang Qiu
It has been reported that the degeneration of cochlear hair cells is the typical cause of presbycusis (or age-related hearing loss). However, the molecular mechanisms that mediate cochlear hair cell apoptosis are not yet fully understood and there is no effective treatment for this disorder. MicroRNAs (miRNAs or miRs) have been increasingly shown to be associated with age-related diseases and are emerging as promising therapeutic targets. In this study, we investigated whether miR-29b is involved in the degeneration of cochlear hair cells...
September 14, 2016: International Journal of Molecular Medicine
Kapil Wattamwar, Z Jason Qian, Jenna Otter, Matthew J Leskowitz, Francesco F Caruana, Barbara Siedlecki, Jaclyn B Spitzer, Anil K Lalwani
Importance: There is a critical disparity in knowledge regarding the rate and nature of hearing loss in the older old (80 years and older). Objective: To determine if the rate of age-related hearing loss is constant in the older old. Design, Setting, and Participants: We performed a retrospective review that began on August 1, 2014, with audiometric evaluations at an academic medical center of 647 patients aged between 80 and 106 years, of whom 141 had multiple audiograms...
September 15, 2016: JAMA Otolaryngology—Head & Neck Surgery
Santoshi Kumari Manche, Madhavi Jangala, Padmavathi Putta, Raja Meganadh Koralla, Jyothy Akka
INTRODUCTION: Presbycusis is characterised by etiopathological changes in the cochlea of the inner ear due to genetic and environmental factors and has a serious impact on quality of life. The present study was aimed to evaluate the role of oxidant stress gene polymorphisms in the development of presbycusis. SUBJECTS AND METHODS: 220 subjects with confirmed presbycusis from ENT specialists of MAA ENT hospital, Hyderabad, India from 2012 to 2014 were considered for the study...
November 30, 2016: Gene
Carolina Sánchez-Rodríguez, Eduardo Martín-Sanz, Esperanza Cuadrado, Juan José Granizo, Ricardo Sanz-Fernández
UNLABELLED: Age-related hearing loss (AHL) -presbycusis- is the number one neurodegenerative disorder and top communication deficit of our aged population. Experimental evidence suggests that mitochondrial dysfunction associated with reactive oxygen species (ROS) plays a central role in the aging process of cochlear cells. Dietary antioxidants, in particular polyphenols, have been found to be beneficial in protecting against the generation of ROS in various diseases associated with oxidative stress, such as cancer, neurodegenerative diseases and aging...
October 2016: Experimental Gerontology
W Ma, M Li, F Gao, X Zhang, L Shi, L Yu, B Zhao, W Chen, G Wang, X Wang
BACKGROUND AND PURPOSE: Presbycusis is the most common sensory deficit in the aging population. A recent study reported using a DTI-based tractography technique to identify a lack of integrity in a portion of the auditory pathway in patients with presbycusis. The aim of our study was to investigate the white matter pathology of patients with presbycusis by using a voxel-based analysis that is highly sensitive to local intensity changes in DTI data. MATERIALS AND METHODS: Fifteen patients with presbycusis and 14 age- and sex-matched healthy controls were scanned on a 3T scanner...
July 14, 2016: AJNR. American Journal of Neuroradiology
Guillaume Sacco, Sébastien Gonfrier, Bernard Teboul, Ivan Gahide, Fredéric Prate, Mathilde Demory-Zory, Jean-Michel Turpin, Claire Vuagnoux, Philippe Genovese, Stéphane Schneider, Olivier Guérin, Nicolas Guevara
BACKGROUND: Presbycusis has a direct influence on autonomy of the elderly but hearing aids lack of affordability. Moreover a recent review demonstrate that electroacoustic characteristics of OTC hearing aids were generally not suitable for the elderly people. In our study, we assessed the clinical value of a new over-the-counter (OTC) hearing aid device (TEO First®) in the elderly. METHOD: This prospective monocentric open label study included patients over 60 years of age with a mild to moderate presbycusis...
2016: BMC Geriatrics
N Fischer, B Weber, H Riechelmann
Presbycusis or age related hearing loss can be defined as a progressive, bilateral and symmetrical sensorineural hearing loss due to age related degeneration of inner ear structures. It can be considered a multifactorial complex disorder with environmental and genetic factors. The molecular, electrophysiological and histological damage at different levels of the inner ear cause a progressive hearing loss, which usually affects the high frequencies of hearing. The resulting poor speech recognition has a negative impact on cognitive, emotional and social function in older adults...
July 2016: Laryngo- Rhino- Otologie
Reuven Ishai, Christopher F Halpin, Michael J McKenna, Alicia M Quesnel
OBJECTIVES: 1) To evaluate the long-term (≥10 year) clinical incidence of endolymphatic hydrops (EH) after stapedectomy for otosclerosis, using low-frequency sensorineural hearing loss (LFSNHL) as a marker for EH. 2) To determine the histologic incidence of EH in human temporal bone specimens (TBS) with a history of stapedectomy for otosclerosis. 3) To determine the histologic incidence of EH in a control group of human TBS. STUDY DESIGN: Retrospective review and temporal bone study...
August 2016: Otology & Neurotology
Gibbeum Kim, Wondo Na, Gungu Kim, Woojae Han, Jinsook Kim
PURPOSE: The present study aimed to develop and standardize a screening tool for elderly people who wish to check for themselves their level of hearing loss. METHODS: The Self-assessment for Hearing Screening of the Elderly (SHSE) consisted of 20 questions based on the characteristics of presbycusis using a five-point scale: seven questions covered general issues related to sensorineural hearing loss, seven covered hearing difficulty under distracting listening conditions, two covered hearing difficulty with fast-rated speech, and four covered the working memory function during communication...
2016: Clinical Interventions in Aging
Erol J Ozmeral, Ann C Eddins, D Robert Frisina, David A Eddins
The auditory system relies on extraordinarily precise timing cues for the accurate perception of speech, music, and object identification. Epidemiological research has documented the age-related progressive decline in hearing sensitivity that is known to be a major health concern for the elderly. Although smaller investigations indicate that auditory temporal processing also declines with age, such measures have not been included in larger studies. Temporal gap detection thresholds (TGDTs; an index of auditory temporal resolution) measured in 1071 listeners (aged 18-98 years) were shown to decline at a minimum rate of 1...
July 2016: Neurobiology of Aging
Hassan Ghasemi, Malihe Shahidi Pourakbari, Morteza Entezari, Mohammad Ebrahim Yarmohammadi
PURPOSE: To evaluate the association between age-related macular degeneration (ARMD) and sensory neural hearing impairment (SHI). METHODS: In this case-control study, hearing status of 46 consecutive patients with ARMD were compared with 46 age-matched cases without clinical ARMD as a control group. In all patients, retinal involvements were confirmed by clinical examination, fluorescein angiography (FA) and optical coherence tomography (OCT). All participants were examined with an otoscope and underwent audiological tests including pure tone audiometry (PTA), speech reception threshold (SRT), speech discrimination score (SDS), tympanometry, reflex tests and auditory brainstem response (ABR)...
January 2016: Journal of Ophthalmic & Vision Research
Joshua Halonen, Ashley S Hinton, Robert D Frisina, Bo Ding, Xiaoxia Zhu, Joseph P Walton
Age-related hearing loss (ARHL), clinically referred to as presbycusis, is one of the three most prevalent chronic medical conditions of our elderly, with the majority of persons over the age of 60 suffering from some degree of ARHL. The progressive loss of auditory sensitivity and perceptual capability results in significant declines in workplace productivity, quality of life, cognition and abilities to communicate effectively. Aldosterone is a mineralocorticoid hormone produced in the adrenal glands and plays a role in the maintenance of key ion pumps, including the Na-K(+)-Cl co-transporter 1 or NKCC1, which is involved in homeostatic maintenance of the endocochlear potential...
June 2016: Hearing Research
Luis Roque Reis, Pedro Escada
INTRODUCTION: Age-related hearing changes are the most frequent cause of sensorineural hearing loss in adults. In the literature no studies exist concerning the importance of speechreading in individuals with presbycusis. Equally, no such studies have been carried out with speakers of the Portuguese (Portugal) language. OBJECTIVES: To evaluate whether the intelligibility of words in presbycusis is improved by speechreading, in such a way that looking at the interlocutor's face while he is talking functions like a "third ear", and to determine the statistical relevance of the intelligibility improvement by speechreading...
March 29, 2016: Brazilian Journal of Otorhinolaryngology
Veronica Seccia, Susanna Fortunato, Lodovica Cristofani-Mencacci, Iacopo Dallan, Augusto P Casani, Manuela Latorre, Pierluigi Paggiaro, Maria Laura Bartoli, Stefano Sellari-Franceschini, Chiara Baldini
OBJECTIVES/HYPOTHESIS: To evaluate the clinical features of audiologic impairment and its relationship with the nasal, vestibular, and rheumatologic profile in a cohort of patients with eosinophilic granulomatosis with polyangiitis (EGPA), formerly named Churg-Strauss syndrome. STUDY DESIGN: Prospective cross-sectional study. METHODS: Thirty-nine patients with EGPA, considered controlled according to the Birmingham Vasculitis Activity Score and the Vasculitis Damage Index, underwent a complete audiologic evalutaion with otomicroscopy, impedance audiometry, speech audiometry, and auditory brainstem responses; rhinologic evaluation was made by means of fiberoptic endoscopy and nasal cytology; the clinical evaluation was completed with analysis of the facial function and, in patients with referred vertigo, with videonystagmography (VNG)...
April 14, 2016: Laryngoscope
Kavita Dedhia, Tina Worman, Margaret A Meredith, Jay T Rubinstein
OBJECTIVE: To describe patterns of hearing loss in patients with low-frequency residual hearing after cochlear implantation. STUDY DESIGN: Retrospective chart review. SETTING: Tertiary referral center. PATIENTS: Cochlear implant candidates with immediate postoperative residual low-frequency hearing. INTERVENTIONS: Hybrid or traditional cochlear implant. MAIN OUTCOME MEASURE: Audiograms to measure postoperative hearing...
June 2016: Otology & Neurotology
Ya-Feng Yu, Wen-Ying Wu, Gen-Sheng Xiao, Hong-Yang Ling, Chen Pan
The aim of the present study was to investigate the protective effect of T-type calcium channel blockers against presbycusis, using a C57BL/6J mice model. The expression of three T-type calcium channel receptor subunits in the cochlea of 6-8-week-old C57BL/6J mice was evaluated using reverse transcription-quantitative polymerase chain reaction. The results confirmed that the three subunits were expressed in the cochlea. In addition, the capacity of T-type calcium channel blockers to protect the cochlear hair cells of 24-26-week-old C57BL/6J mice was investigated in mice treated with mibefradil, benidipine or saline for 4 weeks...
March 2016: Experimental and Therapeutic Medicine
Kevin K Ohlemiller, Anna L Kiener, Patricia M Gagnon
We reported earlier that the endocochlear potential (EP) differs between C57BL/6J (B6) and BALB/cJ (BALB) mice, being lower in BALBs by about 10 mV (Ohlemiller et al. Hear Res 220: 10-26, 2006). This difference corresponds to strain differences with respect to the density of marginal cells in cochlear stria vascularis. After about 1 year of age, BALB mice also tend toward EP reduction that correlates with further marginal cell loss. We therefore suggested that early sub-clinical features of the BALB stria vascularis may predispose these mice to a condition modeling Schuknecht's strial presbycusis...
June 2016: Journal of the Association for Research in Otolaryngology: JARO
K K Shrestha, S Shah, N S Malla, A K Jha, R R Joshi, A S Rijal, A Dhungana
Hearing loss is the most common sensory deficit in the elderly, and is becoming a severe social and health problem. Presbycusis is the result of aging which can lead to communication problems compromising the quality of life (QoL).Since the elderly population is increasing worldwide, presbycusis is showing a similar trend. This study intended to identify the impact of hearing loss in the social life of the elderly. A total of 70 elderly patients attending Nepal Medical College Teaching Hospital who were found to have sensorineural hearing loss (SNHL) on pure tone audiometry (PTA) were recruited for this study...
December 2014: Nepal Medical College Journal: NMCJ
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