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Presbycusis

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https://www.readbyqxmd.com/read/29757919/prevalence-of-ototoxic-medication-use-among-older-adults-in-beaver-dam-wisconsin
#1
Yoonmee Joo, Karen J Cruickshanks, Barbara E K Klein, Ronald Klein, OiSaeng Hong, Margaret Wallhagen
BACKGROUND AND PURPOSE: Drug-related ototoxicity may exacerbate presbycusis (age-related hearing loss); yet, few data are available on the prevalence of ototoxic medication use by older adults. The purposes of this study were to assess the impact of aging and ototoxicity on hearing loss, the prevalence of ototoxic medication use, and select characteristics associated with ototoxic medication use among older adults. METHODS: Cross-sectional analyses were conducted using select variables extracted from the baseline and 10-year follow-up assessments of the two population-based epidemiological studies to compare two points in time...
January 2018: Journal of the American Association of Nurse Practitioners
https://www.readbyqxmd.com/read/29710133/extending-the-ear-kidney-association-to-presbycusis
#2
Edwin M Monsell
No abstract text is available yet for this article.
April 26, 2018: JAMA Otolaryngology—Head & Neck Surgery
https://www.readbyqxmd.com/read/29681993/noise-exposure-and-auditory-thresholds-of-military-musicians-a-follow-up-study
#3
Reinhard Müller, Joachim Schneider
Background: Military musicians are working in a noisy environment with high sound exposure levels above the international standards. Aim of the current study is to find out, whether they develop the expected hearing impairments. Adherence to the regulations for prevention in musicians is more difficult than in other occupational fields. Methods: In an interval of 13.3 years, 36 out of 58 male military musicians of a German army music corps were subjected twice to an audiometric audit...
2018: Journal of Occupational Medicine and Toxicology
https://www.readbyqxmd.com/read/29681847/cholinergic-hypofunction-in-presbycusis-related-tinnitus-with-cognitive-function-impairment-emerging-hypotheses
#4
Qingwei Ruan, Zhuowei Yu, Weibin Zhang, Jian Ruan, Chunhui Liu, Ruxin Zhang
Presbycusis (age-related hearing loss) is a potential risk factor for tinnitus and cognitive deterioration, which result in poor life quality. Presbycusis-related tinnitus with cognitive impairment is a common phenotype in the elderly population. In these individuals, the central auditory system shows similar pathophysiological alterations as those observed in Alzheimer's disease (AD), including cholinergic hypofunction, epileptiform-like network synchronization, chronic inflammation, and reduced GABAergic inhibition and neural plasticity...
2018: Frontiers in Aging Neuroscience
https://www.readbyqxmd.com/read/29661329/hearing-loss-in-the-elderly
#5
REVIEW
Rohan Patel, Brian J McKinnon
Presbycusis, or age-related hearing loss (ARHL), is the result of physiologic and pathologic changes associated with advancing age. ARHL presents typically with a high-frequency hearing loss, which contributes to greater trouble hearing consonants within words. Consonants convey the bulk of meaning within a word, and this loss of linguistic information results in complaints associated with ARHL. Hearing aids and cochlear implants significantly improve the lives of older adults with hearing loss, in particular, those with depression and dementia...
May 2018: Clinics in Geriatric Medicine
https://www.readbyqxmd.com/read/29593512/presbycusis-disrupts-spontaneous-activity-revealed-by-resting-state-functional-mri
#6
Yu-Chen Chen, Huiyou Chen, Liang Jiang, Fan Bo, Jin-Jing Xu, Cun-Nan Mao, Richard Salvi, Xindao Yin, Guangming Lu, Jian-Ping Gu
Purpose : Presbycusis, age-related hearing loss, is believed to involve neural changes in the central nervous system, which is associated with an increased risk of cognitive impairment. The goal of this study was to determine if presbycusis disrupted spontaneous neural activity in specific brain areas involved in auditory processing, attention and cognitive function using resting-state functional magnetic resonance imaging (fMRI) approach. Methods : Hearing and resting-state fMRI measurements were obtained from 22 presbycusis patients and 23 age-, sex- and education-matched healthy controls...
2018: Frontiers in Behavioral Neuroscience
https://www.readbyqxmd.com/read/29556173/impact-of-aging-on-the-auditory-system-and-related-cognitive-functions-a-narrative-review
#7
REVIEW
Dona M P Jayakody, Peter L Friedland, Ralph N Martins, Hamid R Sohrabi
Age-related hearing loss (ARHL), presbycusis, is a chronic health condition that affects approximately one-third of the world's population. The peripheral and central hearing alterations associated with age-related hearing loss have a profound impact on perception of verbal and non-verbal auditory stimuli. The high prevalence of hearing loss in the older adults corresponds to the increased frequency of dementia in this population. Therefore, researchers have focused their attention on age-related central effects that occur independent of the peripheral hearing loss as well as central effects of peripheral hearing loss and its association with cognitive decline and dementia...
2018: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/29453205/codeficiency-of-lysosomal-mucolipins-3-and-1-in-cochlear-hair-cells-diminishes-outer-hair-cell-longevity-and-accelerates-age-related-hearing-loss
#8
Teerawat Wiwatpanit, Natalie N Remis, Aisha Ahmad, Yingjie Zhou, John C Clancy, Mary Ann Cheatham, Jaime García-Añoveros
Acquired hearing loss is the predominant neurodegenerative condition associated with aging in humans. Although mutations on several genes are known to cause congenital deafness in newborns, few genes have been implicated in age-related hearing loss (ARHL), perhaps because its cause is likely polygenic. Here, we generated mice lacking lysosomal calcium channel mucolipins 3 and 1 and discovered that both male and female mice suffered a polygenic form of hearing loss. Whereas mucolipin 1 is ubiquitously expressed in all cells, mucolipin 3 is expressed in a small subset of cochlear cells, hair cells (HCs) and marginal cells of the stria vascularis, and very few other cell types...
March 28, 2018: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/29446191/speech-understanding-in-noise-in-elderly-adults-the-effect-of-inhibitory-control-and-syntactic-complexity
#9
Eline C van Knijff, Martine Coene, Paul J Govaerts
BACKGROUND: Previous research has suggested that speech perception in elderly adults is influenced not only by age-related hearing loss or presbycusis but also by declines in cognitive abilities, by background noise and by the syntactic complexity of the message. AIMS: To gain further insight into the influence of these cognitive as well as acoustic and linguistic factors on speech perception in elderly adults by investigating inhibitory control as a listener characteristic and background noise type and syntactic complexity as input characteristics...
February 15, 2018: International Journal of Language & Communication Disorders
https://www.readbyqxmd.com/read/29392088/micrornas-and-presbycusis
#10
REVIEW
Weiming Hu, Junwu Wu, Wenjing Jiang, Jianguo Tang
Presbycusis (age-related hearing loss) is the most universal sensory degenerative disease in elderly people caused by the degeneration of cochlear cells. Non-coding microRNAs (miRNAs) play a fundamental role in gene regulation in almost every multicellular organism, and control the aging processes. It has been identified that various miRNAs are up- or down-regulated during mammalian aging processes in tissue-specific manners. Most miRNAs bind to specific sites on their target messenger-RNAs (mRNAs) and decrease their expression...
February 2018: Aging and Disease
https://www.readbyqxmd.com/read/29369772/polymorphisms-in-folate-metabolism-genes-are-associated-with-susceptibility-to-presbycusis
#11
Santoshi Kumari Manche, Madhavi Jangala, Dinesh Dudekula, Meganadh Koralla, Jyothy Akka
AIM: Presbycusis or age related hearing loss is caused by several extrinsic and intrinsic factors that damage the auditory system. Gene polymorphisms in folate metabolism were found to play an important role in the etiology of presbycusis. The present study aimed to investigate the role of 5,10-methylenetetrahydrofolate reductase (MTHFR), methionine synthase (MTR) and thymidylate synthase (TYMS) gene polymorphisms in the onset of presbycusis in a South Indian population. MAIN METHODS: A total of 220 subjects confirmed with presbycusis along with 270 age and sex matched healthy controls visiting MAA ENT Hospitals, Hyderabad, India were enrolled for the study...
March 1, 2018: Life Sciences
https://www.readbyqxmd.com/read/29344647/autophagy-regulates-the-degeneration-of-the-auditory-cortex-through-the-ampk-mtor-ulk1-signaling-pathway
#12
Jie Yuan, Xueyan Zhao, Yujuan Hu, Haiying Sun, Guoqing Gong, Xiang Huang, Xubo Chen, Mingyu Xia, Chen Sun, Qilin Huang, Yu Sun, Wen Kong, Weijia Kong
Presbycusis is the most common sensory impairment associated with aging; however, the underlying molecular mechanism remains unclear. Autophagy has been demonstrated to serve a key role in diverse diseases; however, no studies have examined its function in central presbycusis. The aim of the present study was to investigate the changes of autophagy in the physiological processes of the auditory cortex and its role in the degeneration of the auditory cortex, as well as the related mechanisms using naturally aging rats and a D‑galactose (D‑gal)‑induced mimetic rat model of aging...
January 17, 2018: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/29343467/hearing-impairment-in-patients-with-myotonic-dystrophy-type-2
#13
Judith van Vliet, Alide A Tieleman, Baziel G M van Engelen, Guillaume Bassez, Laurent Servais, Anthony Béhin, Tanya Stojkovic, Jan Meulstee, Joost A M Engel, George Lamas, Bruno Eymard, Wim I M Verhagen, Elisabeth Mamelle
OBJECTIVE: To systematically assess auditory characteristics of a large cohort of patients with genetically confirmed myotonic dystrophy type 2 (DM2). METHODS: Patients with DM2 were included prospectively in an international cross-sectional study. A structured interview about hearing symptoms was held. Thereafter, standardized otologic examination, pure tone audiometry (PTA; 0.25, 0.5, 1, 2, 4, and 8 kHz), speech audiometry, tympanometry, acoustic middle ear muscle reflexes, and brainstem auditory evoked potentials (BAEP) were performed...
February 13, 2018: Neurology
https://www.readbyqxmd.com/read/29327687/effect-of-speechreading-in-presbycusis-do-we-have-a-third-ear
#14
Luis Roque Reis, Pedro Escada
INTRODUCTION: Evidence regarding the effect of speechreading is lacking in age-related hearing loss (presbycusis). Thus, in individuals with presbycusis, this study determined whether speechreading would improve word intelligibility. Moreover, the study investigated the effect of speechreading on word intelligibility depending on hearing impairment severity. MATERIALS AND METHODS: This analytical, cross-sectional study involved two groups of individuals aged > 65 years that were enrolled by convenience sampling: 29 individuals with bilateral sensorineural hearing loss compatible with presbycusis (n=58 ears; mean age, 74...
December 30, 2017: Otolaryngologia Polska
https://www.readbyqxmd.com/read/29325454/down-expression-of-p2rx2-kcnq5-erbb3-and-socs3-through-dna-hypermethylation-in-elderly-women-with-presbycusis
#15
Amal Bouzid, Ibtihel Smeti, Leila Dhouib, Magali Roche, Imen Achour, Aida Khalfallah, Abdullah Ahmed Gibriel, Ilhem Charfeddine, Hammadi Ayadi, Joel Lachuer, Abdelmonem Ghorbel, Christine Petit, Saber Masmoudi
CONTEXT: Presbycusis, an age-related hearing impairment (ARHI), represents the most common sensory disability in adults. Today, the molecular mechanisms underlying presbycusis remain unclear. This is in particular due to the fact that ARHI is a multifactorial complex disorder resulting from several genomic factors interacting with lifelong cumulative effects of: disease, diet, and environment. OBJECTIVE: Identification of novel biomarkers for presbycusis. MATERIALS AND METHODS: We selectively ascertained 18 elderly unrelated women lacking environmental and metabolic risk factors...
January 31, 2018: Biomarkers: Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals
https://www.readbyqxmd.com/read/29236268/presbycusis-peripheral-and-central
#16
Kourosh Parham, Karen M Kost
No abstract text is available yet for this article.
December 2017: Ear, Nose, & Throat Journal
https://www.readbyqxmd.com/read/29211164/screening-of-hearing-in-elderly-people-assessment-of-accuracy-and-reproducibility-of-the-whispered-voice-test
#17
Ludimila Labanca, Fernando Sales Guimarães, Letícia Pimenta Costa-Guarisco, Erica de Araújo Brandão Couto, Denise Utsch Gonçalves
Given the high prevalence of presbycusis and its detrimental effect on quality of life, screening tests can be useful tools for detecting hearing loss in primary care settings. This study therefore aimed to determine the accuracy and reproducibility of the whispered voice test as a screening method for detecting hearing impairment in older people. This cross-sectional study was carried out with 210 older adults aged between 60 and 97 years who underwent the whispered voice test employing ten different phrases and using audiometry as a reference test...
November 2017: Ciência & Saúde Coletiva
https://www.readbyqxmd.com/read/29211163/perception-of-hearing-loss-use-of-the-subjective-faces-scale-to-screen-hearing-among-the-elderly
#18
Letícia Pimenta Costa-Guarisco, Daniela Dalpubel, Ludimila Labanca, Marcos Hortes Nisihara Chagas
Presbycusis is a disorder present among the elderly. However, it is under-diagnosed, making it important to develop and enhance simple screening tools. OBJECTIVE: The subjective faces scale has been proposed as a method to assess auditory self-perception among the elderly, and its correlation with audiological tests. METHODS: We looked at elderly patients referred to the audiology service of a reference center for the care of the elderly in a public university hospital between February and November 2013...
November 2017: Ciência & Saúde Coletiva
https://www.readbyqxmd.com/read/29191823/lyric-hearing-aid-a-rare-cause-of-benign-necrotising-otitis-externa-external-ear-canal-cholesteatoma
#19
Christopher Thompson, Rohit Gohil, Alex Bennett
An 80-year-old Caucasian man presented with an incidental and asymptomatic lesion in his right ear thought to be secondary to his use of hearing aids for presbycusis. He used Lyric hearing aids, designed for 24 hours-a-day use for 4 months at a time and had no other previous otological problems. He underwent a bony meatoplasty and vascular flap reconstruction via a retroauricular approach to remove the lesion for histological analysis and regrafting of the area. The lesion was confirmed on histopathology as an ear canal cholesteatoma...
November 29, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/29163129/biomarkers-of-presbycusis-and-tinnitus-in-a-portuguese-older-population
#20
Haúla F Haider, Marisa Flook, Mariana Aparicio, Diogo Ribeiro, Marilia Antunes, Agnieszka J Szczepek, Derek J Hoare, Graça Fialho, João C Paço, Helena Caria
Introduction: Presbycusis or age-related hearing loss (ARHL) is a ubiquitous health problem. It is estimated that it will affect up to 1.5 billion people by 2025. In addition, tinnitus occurs in a large majority of cases with presbycusis. Glutamate metabotropic receptor 7 ( GRM7 ) and N -acetyltransferase 2 ( NAT2 ) are some of the genetic markers for presbycusis. Objectives: To explore patterns of hearing loss and the role of GRM7 and NAT2 as possible markers of presbycusis and tinnitus in a Portuguese population sample...
2017: Frontiers in Aging Neuroscience
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