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Presbycusis

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https://www.readbyqxmd.com/read/29030131/effects-of-diabetes-mellitus-and-systemic-arterial-hypertension-on-elderly-patients-hearing
#1
Laurie Penha Rolim, Alessandra Giannella Samelli, Renata Rodrigues Moreira, Carla Gentile Matas, Itamar de Souza Santos, Isabela Martins Bensenor, Paulo Andrade Lotufo
INTRODUCTION: Chronic diseases can act as an accelerating factor in the auditory system degeneration. Studies on the association between presbycusis and diabetes mellitus and systemic arterial hypertension have shown controversial conclusions. OBJECTIVE: To compare the initial audiometry (A1) with a subsequent audiometry (A2) performed after a 3 to 4-year interval in a population of elderly patients with diabetes mellitus and/or systemic arterial hypertension, to verify whether hearing loss in these groups is more accelerated when compared to controls without these clinical conditions...
September 21, 2017: Brazilian Journal of Otorhinolaryngology
https://www.readbyqxmd.com/read/29017893/chronic-inflammation-inflammaging-in-the-ageing-cochlea-a-novel-target-for-future-presbycusis-therapy
#2
Nathan Watson, Bo Ding, Xiaoxia Zhu, Robert D Frisina
Chronic, low-grade inflammation, or inflammaging, is a crucial contributor to various age-related pathologies and natural processes in aging tissue, including the nervous system. Over the past two decades, much effort has been done to understand the mechanisms of inflammaging in disease models such as type II diabetes, cardiovascular disease, Alzheimer's disease, Parkinson's disease, and others. However, despite being the most prevalent neurodegenerative disorder, the number one communication disorder, and one of the top three chronic medical conditions of our aged population; little research has been conducted on the potential role of inflammation in age-related hearing loss (ARHL)...
November 2017: Ageing Research Reviews
https://www.readbyqxmd.com/read/28990052/macrophage-migration-inhibitory-factor-knockdown-inhibit-viability-and-induce-apoptosis-of-pvm-ms
#3
Wenjing Zhang, Jian Zheng, Juan Meng, Lingling Neng, Xiaohua Chen, Zhaobing Qin
Previous studies have suggested that macrophage migration inhibitory factor (MIF) serves an important role in hearing function; however, the underlying mechanism remains unclear. In the present study, perivascular‑resident macrophage‑like melanocytes (PVM/Ms) from the stria vascularis of the lateral cochlear wall in young and aged mice were isolated. The mRNA and protein expression levels of MIF were determined using reverse transcription‑quantitative polymerase chain reaction analysis, and western blotting, respectively...
December 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28931742/barn-owls-have-ageless-ears
#4
Bianca Krumm, Georg Klump, Christine Köppl, Ulrike Langemann
We measured the auditory sensitivity of the barn owl (Tyto alba), using a behavioural Go/NoGo paradigm in two different age groups, one younger than 2 years (n = 4) and another more than 13 years of age (n = 3). In addition, we obtained thresholds from one individual aged 23 years, three times during its lifetime. For computing audiograms, we presented test frequencies of between 0.5 and 12 kHz, covering the hearing range of the barn owl. Average thresholds in quiet were below 0 dB sound pressure level (SPL) for frequencies between 1 and 10 kHz...
September 27, 2017: Proceedings. Biological Sciences
https://www.readbyqxmd.com/read/28894825/hearing-loss-as-a-risk-factor-for-dementia-a-systematic-review
#5
REVIEW
Rhett S Thomson, Priscilla Auduong, Alexander T Miller, Richard K Gurgel
OBJECTIVES: To review evidence of hearing loss as a risk factor for dementia. Data Sources: PubMed Review methods: A systematic review was conducted using the PubMed database using the search terms (hearing loss OR presbycusis) AND (dementia OR cognitive decline). Initially, 488 articles were obtained. Only those studies evaluating an association between hearing loss and incident dementia or cognitive decline were included in the analysis. This resulted in 17 articles which were thoroughly evaluated with consideration for study design, method for determining hearing loss and cognitive status, relevant covariates and confounding factors, and key findings...
April 2017: Laryngoscope Investigative Otolaryngology
https://www.readbyqxmd.com/read/28862007/-speech-intelligibility-in-noise-at-presbycusis
#6
Olga Dlouhá, Jan Vokřál, Libor Černý
Evaluation of speech recognition is possible by presenting testing material in sentence form with presence of competitive noise. We developed new test of sentence intelligibility in noise in the Czech language. This article demonstrates results of the influence of the babble noise on sentence intelligibility in hearing impaired listeners with presbycusis. The time characteristics of babble noise are similar to human voice. That is the reason why this noise masking is more enhanced at the central hearing level than any other noise masking...
2017: Casopís Lékar̆ů C̆eských
https://www.readbyqxmd.com/read/28705608/the-impact-of-hearing-aids-and-age-related-hearing-loss-on-auditory-plasticity-across-three-months-an-electrical-neuroimaging-study
#7
Nathalie Giroud, Ulrike Lemke, Philip Reich, Katarina L Matthes, Martin Meyer
The present study investigates behavioral and electrophysiological auditory and cognitive-related plasticity in three groups of healthy older adults (60-77 years). Group 1 was moderately hearing-impaired, experienced hearing aid users, and fitted with new hearing aids using non-linear frequency compression (NLFC on); Group 2, also moderately hearing-impaired, used the same type of hearing aids but NLFC was switched off during the entire period of study duration (NLFC off); Group 3 represented individuals with age-appropriate hearing (NHO) as controls, who were not different in IQ, gender, or age from Group 1 and 2...
June 29, 2017: Hearing Research
https://www.readbyqxmd.com/read/28598686/how-your-ears-can-tell-what-is-hidden-in-your-heart-wild-type-transthyretin-amyloidosis-as-potential-cause-of-sensorineural-hearing-loss-inelderly-amylodeafness-pilot-study
#8
Emilie Béquignon, Aziz Guellich, Sophie Barthier, Marc Raynal, Virginie Prulière-Escabasse, Florence Canouï-Poitrine, André Coste, Thibaud Damy
BACKGROUND: Wild-type transthyretin amyloidosis (ATTRwt) is an age-related life-threatening condition. Prognosis is mainly dependent on cardiac involvement. Other organs and tissues may be affected. Their early recognition may increase awareness of physicians and positively affects the prognosis. Presbycusis is another age-related disorder. Whether this disease is associated to ATTRwt amyloidosis is unknown. METHODS: Sixteen consecutive patients with confirmed diagnosis of ATTRwt amyloidosis at the Mondor Amyloidosis Network, France, underwent otoscopy and audiological tests including pure tone audiometry, speech reception threshold and speech discrimination score...
June 9, 2017: Amyloid: the International Journal of Experimental and Clinical Investigation
https://www.readbyqxmd.com/read/28593132/activation-of-wnt-%C3%AE-catenin-signaling-by-lithium-chloride-attenuates-d-galactose-induced-neurodegeneration-in-the-auditory-cortex-of-a-rat-model-of-aging
#9
Ming-Yu Xia, Xue-Yan Zhao, Qi-Lin Huang, Hai-Ying Sun, Chen Sun, Jie Yuan, Chang He, Yu Sun, Xiang Huang, Wen Kong, Wei-Jia Kong
Degeneration of the central auditory system, which is characterized by reduced understanding of speech and source localization of sounds, is an important cause of age-related hearing loss (presbycusis). Accumulating evidence has demonstrated that Wnt/β-catenin signaling plays an essential role in the development of the auditory system but its potential role in presbycusis remains unclear. In this study, we used a rat model of aging, created by chronic systemic exposure to d-galactose (d-gal), and explored changes in Wnt/β-catenin signaling in the auditory cortex...
June 2017: FEBS Open Bio
https://www.readbyqxmd.com/read/28590900/the-association-between-hearing-loss-postural-control-and-mobility-in-older-adults-a-systematic-review
#10
REVIEW
Maayan Agmon, Limor Lavie, Michail Doumas
BACKGROUND: Degraded hearing in older adults has been associated with reduced postural control and higher risk of falls. Both hearing loss (HL) and falls have dramatic effects on older persons' quality of life (QoL). A large body of research explored the comorbidity between the two domains. PURPOSE: The aim of the current review is to describe the comorbidity between HL and objective measures of postural control, to offer potential mechanisms underlying this relationship, and to discuss the clinical implications of this comorbidity...
June 2017: Journal of the American Academy of Audiology
https://www.readbyqxmd.com/read/28579956/music-training-and-education-slow-the-deterioration-of-music-perception-produced-by-presbycusis-in-the-elderly
#11
Felipe N Moreno-Gómez, Guillermo Véliz, Marcos Rojas, Cristián Martínez, Rubén Olmedo, Felipe Panussis, Alexies Dagnino-Subiabre, Carolina Delgado, Paul H Delano
The perception of music depends on the normal function of the peripheral and central auditory system. Aged subjects without hearing loss have altered music perception, including pitch and temporal features. Presbycusis or age-related hearing loss is a frequent condition in elderly people, produced by neurodegenerative processes that affect the cochlear receptor cells and brain circuits involved in auditory perception. Clinically, presbycusis patients have bilateral high-frequency hearing loss and deteriorated speech intelligibility...
2017: Frontiers in Aging Neuroscience
https://www.readbyqxmd.com/read/28557400/-the-effectiveness-of-hearing-aids-in-elderly-people
#12
M Yu Boboshko, L E Golovanova, E V Zhilinskaia, E A Ogorodnikova
The analysis of factors which influence on the hearing aid efficacy in elderly with presbycusis is presented in the article. 125 patients from 60 to 90 years old with moderate to severe hearing loss, hearing aid users, were examined. The audiology examination included standard methods as well as tests evaluating central auditory pathways processing. According to the results of speech audiometry in free field low efficacy of hearing aid is revealed in 21 % patients. The main factor that decreases hearing aid benefit is the presence of central auditory processing disorders, the additional one is poor technical characteristics of a hearing aid...
2017: Advances in Gerontology, Uspekhi Gerontologii
https://www.readbyqxmd.com/read/28553093/applications-of-direct-to-consumer-hearing-devices-for-adults-with-hearing-loss-a-review
#13
REVIEW
Vinaya Manchaiah, Brian Taylor, Ashley L Dockens, Nicole R Tran, Kayla Lane, Mariana Castle, Vibhu Grover
BACKGROUND: This systematic literature review is aimed at investigating applications of direct-to-consumer hearing devices for adults with hearing loss. This review discusses three categories of direct-to-consumer hearing devices: 1) personal sound amplification products (PSAPs), 2) direct-mail hearing aids, and 3) over-the-counter (OTC) hearing aids. METHOD: A literature review was conducted using EBSCOhost and included the databases CINAHL, MEDLINE, and PsycINFO...
2017: Clinical Interventions in Aging
https://www.readbyqxmd.com/read/28499253/the-role-of-sodium-hydrosulfide-in-attenuating-the-aging-process-via-pi3k-akt-and-camkk%C3%AE-ampk-pathways
#14
Xubo Chen, Xueyan Zhao, Hua Cai, Haiying Sun, Yujuan Hu, Xiang Huang, Wen Kong, Weijia Kong
Age-related dysfunction of the central auditory system, known as central presbycusis, is characterized by defects in speech perception and sound localization. It is important to determine the pathogenesis of central presbycusis in order to explore a feasible and effective intervention method. Recent work has provided fascinating insight into the beneficial function of H2S on oxidative stress and stress-related disease. In this study, we investigated the pathogenesis of central presbycusis and tried to explore the mechanism of H2S action on different aspects of aging by utilizing a mimetic aging rat and senescent cellular model...
August 2017: Redox Biology
https://www.readbyqxmd.com/read/28498466/elevated-slc26a4-gene-promoter-methylation-is-associated-with-the-risk-of-presbycusis-in-men
#15
Jin Xu, Jiachen Zheng, Wanjing Shen, Lili Ma, Ming Zhao, Xubo Wang, Jiyuan Tang, Jihong Yan, Zhenhua Wu, Zuquan Zou, Shizhong Bu, Yang Xi
Presbycusis affects approximately one-third of people over the age of 65 and is a worldwide health problem. In the current study, whether the methylation level of solute carrier family 26 member 4 (SLC26A4) predicted an increased risk of presbycusis was investigated. Peripheral blood samples from 102 patients with presbycusis and 104 controls were collected, and the methylation of the CpG sites of SLC26A4 was measured by applying pyrosequencing technology combined with sodium bisulfate DNA conversion chemistry...
July 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28424544/association-of-genetic-variations-in-the-mitochondrial-dna-control-region-with-presbycusis
#16
Masoumeh Falah, Mohammad Farhadi, Seyed Kamran Kamrava, Saeid Mahmoudian, Ahmad Daneshi, Maryam Balali, Alimohamad Asghari, Massoud Houshmand
BACKGROUND: The prominent role of mitochondria in the generation of reactive oxygen species, cell death, and energy production contributes to the importance of this organelle in the intracellular mechanism underlying the progression of the common sensory disorder of the elderly, presbycusis. Reduced mitochondrial DNA (mtDNA) gene expression and coding region variation have frequently been reported as being associated with the development of presbycusis. The mtDNA control region regulates gene expression and replication of the genome of this organelle...
2017: Clinical Interventions in Aging
https://www.readbyqxmd.com/read/28420774/preventing-noise-induced-hearing-loss
#17
Julia Doswell Royster
Noise-induced hearing loss (NIHL) is second only to presbycusis, age-related hearing loss, as a cause of hearing impairment; yet, it is preventable. This commentary summarizes the effects of noise on hearing, relevant workplace regulations, and ways to minimize excessive noise's deleterious impact on individuals' quality of life on and off the job.
March 2017: North Carolina Medical Journal
https://www.readbyqxmd.com/read/28407635/role-of-the-ubiquitin-c-terminal-hydrolase-l1-modulated-ubiquitin-proteasome-system-in-auditory-cortex-senescence
#18
Ya Zhang, Xiang Huang, Xue-Yan Zhao, Yu-Juan Hu, Hai-Ying Sun, Wei-Jia Kong
BACKGROUND/AIMS: According to recent studies, central auditory impairments are closely related to neurodegenerative diseases. However, the mechanism of central presbycusis remains unclear. Ubiquitin C-terminal hydrolase L1 (UCHL1) is important in maintaining proteasomal activity; however, the detailed mechanism has not yet been fully elucidated. This study aims to investigate the molecular alterations involved in UCHL1 regulation during auditory cortex aging. METHODS: D-Galactose (D-gal) induces oxidative stress and senescence in the auditory cortex, as reported in our previous studies...
2017: ORL; Journal for Oto-rhino-laryngology and its related Specialties
https://www.readbyqxmd.com/read/28269769/do-hearing-aids-influence-behavioral-and-psychological-symptoms-of-dementia-and-quality-of-life-in-hearing-impaired-alzheimer-s-disease-patients-and-their-caregivers
#19
Arnaud Adrait, Xavier Perrot, Marie-France Nguyen, Marine Gueugnon, Charles Petitot, Lionel Collet, Adeline Roux, Marc Bonnefoy
BACKGROUND: It has been suggested that age-related hearing loss (ARHL) and Alzheimer's disease (AD) are commonly associated. OBJECTIVE: The Alzheimer Disease, Presbycusis and Hearing Aids (ADPHA) clinical trial assessed the influence of hearing aids (HAs) on patients affected by ARHL and AD, as judged by behavioral symptoms and functional abilities, as well as patient and caregiver quality of life (QoL). METHODS: A multicenter double-blind randomized placebo-controlled trial, with a semi-crossover procedure over 12 months, was conducted from 2006 to 2012...
2017: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/28167132/identification-of-induced-and-naturally-occurring-conductive-hearing-loss-in-mice-using-bone-conduction
#20
David Chhan, Melissa L McKinnon, John J Rosowski
While many mouse models of hearing loss have been described, a significant fraction of the genetic defects in these models affect both the inner ear and middle ears. A common method used to separate inner-ear (sensory-neural) from middle-ear (conductive) pathologies in the hearing clinic is the combination of air-conduction and bone-conduction audiometry. In this report, we investigate the use of air- and bone-conducted evoked auditory brainstem responses to perform a similar separation in mice. We describe a technique by which we stimulate the mouse ear both acoustically and via whole-head vibration...
March 2017: Hearing Research
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