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Presbycusis

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https://www.readbyqxmd.com/read/28269769/do-hearing-aids-influence-behavioral-and-psychological-symptoms-of-dementia-and-quality-of-life-in-hearing-impaired-alzheimer-s-disease-patients-and-their-caregivers
#1
Arnaud Adrait, Xavier Perrot, Marie-France Nguyen, Marine Gueugnon, Charles Petitot, Lionel Collet, Adeline Roux, Marc Bonnefoy
BACKGROUND: It has been suggested that age-related hearing loss (ARHL) and Alzheimer's disease (AD) are commonly associated. OBJECTIVE: The Alzheimer Disease, Presbycusis and Hearing Aids (ADPHA) clinical trial assessed the influence of hearing aids (HAs) on patients affected by ARHL and AD, as judged by behavioral symptoms and functional abilities, as well as patient and caregiver quality of life (QoL). METHODS: A multicenter double-blind randomized placebo-controlled trial, with a semi-crossover procedure over 12 months, was conducted from 2006 to 2012...
March 2, 2017: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/28167132/identification-of-induced-and-naturally-occurring-conductive-hearing-loss-in-mice-using-bone-conduction
#2
David Chhan, Melissa L McKinnon, John J Rosowski
While many mouse models of hearing loss have been described, a significant fraction of the genetic defects in these models affect both the inner ear and middle ears. A common method used to separate inner-ear (sensory-neural) from middle-ear (conductive) pathologies in the hearing clinic is the combination of air-conduction and bone-conduction audiometry. In this report, we investigate the use of air- and bone-conducted evoked auditory brainstem responses to perform a similar separation in mice. We describe a technique by which we stimulate the mouse ear both acoustically and via whole-head vibration...
March 2017: Hearing Research
https://www.readbyqxmd.com/read/28135010/a-population-based-study-of-the-association-between-dysglycaemia-and-hearing-loss-in-middle-age
#3
J Sommer, C G Brenann-Jones, R H Eikelboom, M Hunter, W A Davis, M D Atlas, T M E Davis
AIMS: To investigate the independent associations between hearing loss and dysglycaemia in a sample of middle-aged adults, including separate analysis of those aged <60 years. METHODS: The first 2023 participants in the cross-sectional Busselton Health Ageing Survey were assessed for hearing loss ≥26 dB (better ear) for four-frequency average (4FA) of pure-tone thresholds at 500, 1000, 2000 and 4000 Hz, and high-frequency average (HFA) of pure-tone thresholds at 4000 and 8000 Hz...
January 30, 2017: Diabetic Medicine: a Journal of the British Diabetic Association
https://www.readbyqxmd.com/read/28125514/age-related-change-in-vestibular-ganglion-cell-populations-in-individuals-with-presbycusis-and-normal-hearing
#4
Michael B Gluth, Erik G Nelson
HYPOTHESIS: We sought to establish that the decline of vestibular ganglion cell counts uniquely correlates with spiral ganglion cell counts, cochlear hair cell counts, and hearing phenotype in individuals with presbycusis. BACKGROUND: The relationship between aging in the vestibular system and aging in the cochlea is a topic of ongoing investigation. Histopathologic age-related changes the vestibular system may mirror what is seen in the cochlea, but correlations with hearing phenotype and the impact of presbycusis are not well understood...
April 2017: Otology & Neurotology
https://www.readbyqxmd.com/read/27959434/age-associated-expression-of-erythropoietin-and-its-receptor-in-rat-spiral-ganglion-neurons-and-its-association-with-neuronal-apoptosis-and-hearing-alterations
#5
Cheng Zhong, Xueyuan Zhang
The present study aimed to determine the expression of erythropoietin (EPO) and the EPO receptor (EPOR) in spiral ganglion neurons (SGNs) in the inner ear of rats of various ages, and the associated neuronal apoptosis and hearing alterations. A total of 15 healthy rats (n=30 ears), were divided into three groups: i) A nominated infant group at post‑natal day (PND) 12‑14, ii) an adult group at PND 60 and iii) a 3‑year postnatal aged group. Auditory brainstem response (ABR) measurements were performed on all rats...
January 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/27914909/benefits-pitfalls-and-risks-of-phytotherapy-in-clinical-practice-in-otorhinolaryngology
#6
O Laccourreye, A Werner, L Laccourreye, P Bonfils
OBJECTIVES: To elucidate the benefits, pitfalls and risks of phytotherapy in the clinical practice of otorhinolaryngology. MATERIAL AND METHODS: The PubMed and Cochrane databases were searched using the following keywords: phytotherapy, phytomedicine, herbs, otology, rhinology, laryngology, otitis, rhinitis, laryngitis and otorhinolaryngology. Seventy-two articles (18 prospective randomized studies, 4 Cochrane analyses, 4 meta-analysis and 15 reviews of the literature) devoted to clinical studies were analyzed...
November 30, 2016: European Annals of Otorhinolaryngology, Head and Neck Diseases
https://www.readbyqxmd.com/read/27858145/role-of-antioxidants-in-prevention-of-age-related-hearing-loss-a-review-of-literature
#7
REVIEW
Elham Tavanai, Ghassem Mohammadkhani
Age-related hearing loss (ARHL), also known as presbycusis, is one of the most prevalent chronic degenerative conditions. It is characterized by a decline in auditory function. ARHL is caused by the interaction of multiple factors, including cochlear aging, environment, genetic predisposition, and health comorbidities. The primary pathology of ARHL includes the hair cells loss, stria vascularis atrophy, and loss of spiral ganglion neurons as well as the changes in central auditory pathways. The research to date suggests that oxidative stress and mitochondrial DNA deletion (mtDNA) play a major role in pathophysiology of ARHL...
November 17, 2016: European Archives of Oto-rhino-laryngology
https://www.readbyqxmd.com/read/27853057/noise-induced-hearing-loss-among-professional-musicians
#8
Pouryaghoub Gholamreza, Ramin Mehrdad, Saeed Pourhosein
OBJECTIVES: After presbycusis, noise exposure is considered the second cause of sensorineural hearing loss. Due to exposure to high-intensity sounds, musicians may be at risk of noise-induced hearing loss (NIHL). Given the importance of good hearing in music career, this study aimed to investigate the frequency of hearing loss and use of protective measures among Iranian musicians. METHODS: In this cross-sectional study, 125 musicians, including 21 women (16.8%) and 104 men (83...
November 16, 2016: Journal of Occupational Health
https://www.readbyqxmd.com/read/27799778/the-potential-role-for-use-of-mitochondrial-dna-copy-number-as-predictive-biomarker-in-presbycusis
#9
Masoumeh Falah, Massoud Houshmand, Mohammad Najafi, Maryam Balali, Saeid Mahmoudian, Alimohamad Asghari, Hessamaldin Emamdjomeh, Mohammad Farhadi
OBJECTIVES: Age-related hearing impairment, or presbycusis, is the most common communication disorder and neurodegenerative disease in the elderly. Its prevalence is expected to increase, due to the trend of growth of the elderly population. The current diagnostic test for detection of presbycusis is implemented after there has been a change in hearing sensitivity. Identification of a pre-diagnostic biomarker would raise the possibility of preserving hearing sensitivity before damage occurs...
2016: Therapeutics and Clinical Risk Management
https://www.readbyqxmd.com/read/27792758/discovery-of-cdh23-as-a-significant-contributor-to-progressive-postlingual-sensorineural-hearing-loss-in-koreans
#10
Bong Jik Kim, Ah Reum Kim, Chung Lee, So Young Kim, Nayoung K D Kim, Mun Young Chang, Jihye Rhee, Mi-Hyun Park, Soo Kyung Koo, Min Young Kim, Jin Hee Han, Seung-Ha Oh, Woong-Yang Park, Byung Yoon Choi
CDH23 mutations have mostly been associated with prelingual severe-to-profound sensorineural hearing loss (SNHL) in either syndromic or nonsyndromic SNHL (DFNB12). Herein, we demonstrate the contribution of CDH23 mutations to postlingual nonsyndromic SNHL (NS-SNHL). We screened 32 Korean adult probands with postlingual NS-SNHL sporadically or in autosomal recessive fashion using targeted panel or whole exome sequencing. We identified four (12.5%, 4/32) potential postlingual DFNB12 families that segregated the recessive CDH23 variants, qualifying for our criteria along with rapidly progressive SNHL...
2016: PloS One
https://www.readbyqxmd.com/read/27746834/pitch-and-loudness-tinnitus-in-individuals-with-presbycusis
#11
Bruna Macangnin Seimetz, Adriane Ribeiro Teixeira, Leticia Petersen Schmidt Rosito, Leticia Sousa Flores, Carlos Henrique Pappen, Celso Dall'igna
Introduction Tinnitus is a symptom that is often associated with presbycusis. Objective This study aims to analyze the existence of association among hearing thresholds, pitch, and loudness of tinnitus in individuals with presbycusis, considering the gender variable. Methods Cross-sectional, descriptive, and prospective study, whose sample consisted of individuals with tinnitus and diagnosis of presbycusis. For the evaluation, we performed anamnesis along with otoscopy, pure tone audiometry, and acuphenometry to analyze the psychoacoustic characteristics of tinnitus individuals...
October 2016: International Archives of Otorhinolaryngology
https://www.readbyqxmd.com/read/27667674/age-related-hearing-loss-prevention-of-threshold-declines-cell-loss-and-apoptosis-in-spiral-ganglion-neurons
#12
Robert D Frisina, Bo Ding, Xiaoxia Zhu, Joseph P Walton
Age-related hearing loss (ARHL) -presbycusis - is the most prevalent neurodegenerative disease and number one communication disorder of our aged population; and affects hundreds of millions of people worldwide. Its prevalence is close to that of cardiovascular disease and arthritis, and can be a precursor to dementia. The auditory perceptual dysfunction is well understood, but knowledge of the biological bases of ARHL is still somewhat lacking. Surprisingly, there are no FDA-approved drugs for treatment. Based on our previous studies of human subjects, where we discovered relations between serum aldosterone levels and the severity of ARHL, we treated middle age mice with aldosterone, which normally declines with age in all mammals...
September 23, 2016: Aging
https://www.readbyqxmd.com/read/27635430/mir-29b-overexpression-induces-cochlear-hair-cell-apoptosis-through-the-regulation-of-sirt1-pgc-1%C3%AE-signaling-implications-for-age-related-hearing-loss
#13
Tao Xue, Li Wei, Ding-Jun Zha, Jian-Hua Qiu, Fu-Quan Chen, Li Qiao, Yang Qiu
It has been reported that the degeneration of cochlear hair cells is the typical cause of presbycusis (or age-related hearing loss). However, the molecular mechanisms that mediate cochlear hair cell apoptosis are not yet fully understood and there is no effective treatment for this disorder. MicroRNAs (miRNAs or miRs) have been increasingly shown to be associated with age-related diseases and are emerging as promising therapeutic targets. In this study, we investigated whether miR-29b is involved in the degeneration of cochlear hair cells...
November 2016: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/27632707/increases-in-the-rate-of-age-related-hearing-loss-in-the-older-old
#14
Kapil Wattamwar, Z Jason Qian, Jenna Otter, Matthew J Leskowitz, Francesco F Caruana, Barbara Siedlecki, Jaclyn B Spitzer, Anil K Lalwani
Importance: There is a critical disparity in knowledge regarding the rate and nature of hearing loss in the older old (80 years and older). Objective: To determine if the rate of age-related hearing loss is constant in the older old. Design, Setting, and Participants: We performed a retrospective review that began on August 1, 2014, with audiometric evaluations at an academic medical center of 647 patients aged between 80 and 106 years, of whom 141 had multiple audiograms...
January 1, 2017: JAMA Otolaryngology—Head & Neck Surgery
https://www.readbyqxmd.com/read/27562082/association-of-oxidative-stress-gene-polymorphisms-with-presbycusis
#15
Santoshi Kumari Manche, Madhavi Jangala, Padmavathi Putta, Raja Meganadh Koralla, Jyothy Akka
INTRODUCTION: Presbycusis is characterised by etiopathological changes in the cochlea of the inner ear due to genetic and environmental factors and has a serious impact on quality of life. The present study was aimed to evaluate the role of oxidant stress gene polymorphisms in the development of presbycusis. SUBJECTS AND METHODS: 220 subjects with confirmed presbycusis from ENT specialists of MAA ENT hospital, Hyderabad, India from 2012 to 2014 were considered for the study...
November 30, 2016: Gene
https://www.readbyqxmd.com/read/27426743/protective-effect-of-polyphenols-on-presbycusis-via-oxidative-nitrosative-stress-suppression-in-rats
#16
Carolina Sánchez-Rodríguez, Eduardo Martín-Sanz, Esperanza Cuadrado, Juan José Granizo, Ricardo Sanz-Fernández
UNLABELLED: Age-related hearing loss (AHL) -presbycusis- is the number one neurodegenerative disorder and top communication deficit of our aged population. Experimental evidence suggests that mitochondrial dysfunction associated with reactive oxygen species (ROS) plays a central role in the aging process of cochlear cells. Dietary antioxidants, in particular polyphenols, have been found to be beneficial in protecting against the generation of ROS in various diseases associated with oxidative stress, such as cancer, neurodegenerative diseases and aging...
October 2016: Experimental Gerontology
https://www.readbyqxmd.com/read/27418468/dti-analysis-of-presbycusis-using-voxel-based-analysis
#17
W Ma, M Li, F Gao, X Zhang, L Shi, L Yu, B Zhao, W Chen, G Wang, X Wang
BACKGROUND AND PURPOSE: Presbycusis is the most common sensory deficit in the aging population. A recent study reported using a DTI-based tractography technique to identify a lack of integrity in a portion of the auditory pathway in patients with presbycusis. The aim of our study was to investigate the white matter pathology of patients with presbycusis by using a voxel-based analysis that is highly sensitive to local intensity changes in DTI data. MATERIALS AND METHODS: Fifteen patients with presbycusis and 14 age- and sex-matched healthy controls were scanned on a 3T scanner...
July 14, 2016: AJNR. American Journal of Neuroradiology
https://www.readbyqxmd.com/read/27392722/clinical-evaluation-of-an-over-the-counter-hearing-aid-teo-first%C3%A2-in-elderly-patients-suffering-of-mild-to-moderate-hearing-loss
#18
Guillaume Sacco, Sébastien Gonfrier, Bernard Teboul, Ivan Gahide, Fredéric Prate, Mathilde Demory-Zory, Jean-Michel Turpin, Claire Vuagnoux, Philippe Genovese, Stéphane Schneider, Olivier Guérin, Nicolas Guevara
BACKGROUND: Presbycusis has a direct influence on autonomy of the elderly but hearing aids lack of affordability. Moreover a recent review demonstrate that electroacoustic characteristics of OTC hearing aids were generally not suitable for the elderly people. In our study, we assessed the clinical value of a new over-the-counter (OTC) hearing aid device (TEO First®) in the elderly. METHOD: This prospective monocentric open label study included patients over 60 years of age with a mild to moderate presbycusis...
July 9, 2016: BMC Geriatrics
https://www.readbyqxmd.com/read/27392191/-presbycusis-age-related-hearing-loss
#19
N Fischer, B Weber, H Riechelmann
Presbycusis or age related hearing loss can be defined as a progressive, bilateral and symmetrical sensorineural hearing loss due to age related degeneration of inner ear structures. It can be considered a multifactorial complex disorder with environmental and genetic factors. The molecular, electrophysiological and histological damage at different levels of the inner ear cause a progressive hearing loss, which usually affects the high frequencies of hearing. The resulting poor speech recognition has a negative impact on cognitive, emotional and social function in older adults...
July 2016: Laryngo- Rhino- Otologie
https://www.readbyqxmd.com/read/27380537/how-often-does-stapedectomy-for-otosclerosis-result-in-endolymphatic-hydrops
#20
Reuven Ishai, Christopher F Halpin, Michael J McKenna, Alicia M Quesnel
OBJECTIVES: 1) To evaluate the long-term (≥10 year) clinical incidence of endolymphatic hydrops (EH) after stapedectomy for otosclerosis, using low-frequency sensorineural hearing loss (LFSNHL) as a marker for EH. 2) To determine the histologic incidence of EH in human temporal bone specimens (TBS) with a history of stapedectomy for otosclerosis. 3) To determine the histologic incidence of EH in a control group of human TBS. STUDY DESIGN: Retrospective review and temporal bone study...
August 2016: Otology & Neurotology
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