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https://www.readbyqxmd.com/read/28810550/2d-sti-combined-with-gated-99-tc-m-mibi-mpi-for-the-diagnosis-of-myocardial-ischemia-in-hypercholesterolemia-patients
#1
Yi Song, Rui-Fang Zhang, Yu Liu
This study aimed to investigate the reliability of ultrasound two-dimensional speckle tracking imaging (2D-STI) for the evaluation of myocardial ischemia in familial hypercholesterolemia (FH) patients. We recruited 28 patients clinically diagnosed with homozygous familial hypercholesterolemia (HoFH) and subjected them to 2D-STI, gated transthoracic Doppler echocardiography (TTDE), and (99)Tc(m)-methoxyisobutylisonitrile myocardial perfusion imaging ((99)Tc(m)-MIBI MPI). The sensitivity, specificity and diagnostic accordance rate of TTDE and 2D-STI for myocardial ischemia in HoFH patients were compared with the (99)Tc(m)-MIBI scores...
August 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28807191/cognitive-and-motor-performance-in-congolese-children-with-konzo-during-4-years-of-follow-up-a-longitudinal-analysis
#2
Michael J Boivin, Daniel Okitundu, Bumoko Makila-Mabe, Marie-Therese Sombo, Dieudonne Mumba, Alla Sikorskii, Banea Mayambu, Desire Tshala-Katumbay
BACKGROUND: Konzo is an irreversible upper-motor neuron disorder affecting children dependent on bitter cassava for food. The neurocognitive ability of children with konzo over time has yet to be fully documented. METHODS: We did a longitudinal study in a konzo outbreak zone continuously affected by konzo since 1990, in the district of Kahemba, southern Bandundu Province, Congo. We enrolled children with a record of neurological diagnosis of konzo in Kahemba town...
September 2017: Lancet Global Health
https://www.readbyqxmd.com/read/28800760/perceptions-of-patients-and-providers-on-myocardial-perfusion-imaging-for-asymptomatic-patients-choosing-wisely-and-professional-liability
#3
Kristopher P Kline, Leslee Shaw, Rebecca J Beyth, Jared Plumb, Linda Nguyen, Tianyao Huo, David E Winchester
BACKGROUND: Despite efforts by professional societies to reduce low value care, many reports indicate that unnecessary tests, such as nuclear myocardial perfusion imaging (MPI), are commonly used in contemporary practice. The degree to which lack of awareness and professional liability concerns drive these behaviors warrants further study. We sought to investigate patient and provider perceptions about MPI in asymptomatic patients, the Choosing Wisely (CW) campaign, and professional liability concerns...
August 11, 2017: BMC Health Services Research
https://www.readbyqxmd.com/read/28776314/a-combined-static-dynamic-single-dose-imaging%C3%A2-protocol-to-compare-quantitative-dynamic-spect-with-static-conventional-spect
#4
Maria Sciammarella, Uttam M Shrestha, Youngho Seo, Grant T Gullberg, Elias H Botvinick
BACKGROUND: SPECT myocardial perfusion imaging (MPI) is a clinical mainstay that is typically performed with static imaging protocols and visually or semi-quantitatively assessed for perfusion defects based upon the relative intensity of myocardial regions. Dynamic cardiac SPECT presents a new imaging technique based on time-varying information of radiotracer distribution, which permits the evaluation of regional myocardial blood flow (MBF) and coronary flow reserve (CFR). In this work, a preliminary feasibility study was conducted in a small patient sample designed to implement a unique combined static-dynamic single-dose one-day visit imaging protocol to compare quantitative dynamic SPECT with static conventional SPECT for improving the diagnosis of coronary artery disease (CAD)...
August 3, 2017: Journal of Nuclear Cardiology: Official Publication of the American Society of Nuclear Cardiology
https://www.readbyqxmd.com/read/28776313/a-new-era-in-gated-myocardial-perfusion-imaging-feasibility-of-data-driven-cardiac-contraction-gating-with-multiple-pinhole-czt-spect
#5
Doumit Daou, Rémy Sabbah, Carlos Coaguila, Yousef Alattar, Hatem Boulahdour
BACKGROUND: We previously validated the use of a data-driven cardiac respiratory-motion (RM) correction method (REGAT) applicable to CZT SPECT myocardial perfusion imaging (MPI). In this study, we adapted the same process used with REGAT for RM to generate data-driven cardiac contraction triggers and corresponding cardiac contraction-gated SPECT studies (GSPECT-DD). We aimed to study its feasibility and compare its performances to GSPECT studies generated with ECG monitor-based triggers (GSPECT-ECG)...
August 3, 2017: Journal of Nuclear Cardiology: Official Publication of the American Society of Nuclear Cardiology
https://www.readbyqxmd.com/read/28776202/neurotrophin-gene-therapy-in-deafened-ears-with-cochlear-implants-long-term-effects-on-nerve-survival-and-functional-measures
#6
Bryan E Pfingst, Deborah J Colesa, Donald L Swiderski, Aaron P Hughes, Stefan B Strahl, Moaz Sinan, Yehoash Raphael
Because cochlear implants function by stimulating the auditory nerve, it is assumed that the condition of the nerve plays an important role in the efficacy of the prosthesis. Thus, considerable research has been devoted to methods of preserving the nerve following deafness. Neurotrophins have been identified as a potential contributor to neural health, but most of the research to date has been done in young animals and for short periods (less than 3 to 6 months) after the onset of treatment. The first objective of the current experiment was to examine the effects of a neurotrophin gene therapy delivery method on spiral ganglion neuron (SGN) preservation and function in the long term (5 to 14 months) in mature guinea pigs with cochlear implants...
August 3, 2017: Journal of the Association for Research in Otolaryngology: JARO
https://www.readbyqxmd.com/read/28762450/prognostic-factors-in-acute-mesenteric-ischemia-and-evaluation-with-mannheim-peritonitis-index-and-platelet-to-lymphocyte-ratio
#7
Eyüp Murat Yılmaz, Erdem Barış Cartı
BACKGROUND: Acute mesenteric ischemia (AMI) is a disease that has a very high mortality rate and for which the diagnosis is frequently delayed. The aim of the present study was to assess the predictive value of the Mannheim Peritonitis Index (MPI) and platelet-to-lymphocyte (P/L) ratio in the prognosis of AMI. METHODS: The files of 34 patients diagnosed with AMI between September 2014 and April 2016 were retrospectively examined. The patients were divided into 2 groups based on survival...
July 2017: Ulusal Travma Ve Acil Cerrahi Dergisi, Turkish Journal of Trauma & Emergency Surgery: TJTES
https://www.readbyqxmd.com/read/28761103/towards-picogram-detection-of-superparamagnetic-iron-oxide-particles-using-a-gradiometric-receive-coil
#8
Matthias Graeser, Tobias Knopp, Patryk Szwargulski, Thomas Friedrich, Anselm von Gladiss, Michael Kaul, Kannan M Krishnan, Harald Ittrich, Gerhard Adam, Thorsten M Buzug
Superparamagnetic iron-oxide nanoparticles can be used in medical applications like vascular or targeted imaging. Magnetic particle imaging (MPI) is a promising tomographic imaging technique that allows visualizing the 3D nanoparticle distribution concentration in a non-invasive manner. The two main strengths of MPI are high temporal resolution and high sensitivity. While the first has been proven in the assessment of dynamic processes like cardiac imaging, it is unknown how far the detection limit of MPI can be lowered...
July 31, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28756115/the-effects-of-lactobacillus-reuteri-probiotics-combined-with-azithromycin-on-peri-implantitis-a-randomized-placebo-controlled-study
#9
Hiroaki Tada, Chihiro Masaki, Shintaro Tsuka, Taro Mukaibo, Yusuke Kondo, Ryuji Hosokawa
PURPOSE: The aim of this randomized placebo-controlled clinical study was to investigate the effects of a probiotic tablet containing Lactobacillus reuteri in peri-implantitis patients. METHODS: Subjects comprised 30 patients with mild to moderate peri-implantitis. A baseline clinical examination and microbiological assessment were conducted, followed by an antibiotics treatment (azithromycin, 500mg, once a day for 3 days). Subjects were divided into probiotic and placebo groups...
July 26, 2017: Journal of Prosthodontic Research
https://www.readbyqxmd.com/read/28752313/the-elusive-role-of-myocardial-perfusion-imaging-in-stable-ischemic-heart-disease-is-ischemia-the-answer
#10
Joe X Xie, David E Winchester, Lawrence M Phillips, Rory Hachamovitch, Daniel S Berman, Ron Blankstein, Marcelo F Di Carli, Todd D Miller, Mouaz H Al-Mallah, Leslee J Shaw
The assessment of ischemia through myocardial perfusion imaging (MPI) is widely accepted as an index step in the diagnostic evaluation of stable ischemic heart disease (SIHD). Numerous observational studies have characterized the prognostic significance of ischemia extent and severity. However, the role of ischemia in directing downstream SIHD care including coronary revascularization has remained elusive as reductions in ischemic burden have not translated to improved clinical outcomes in randomized trials...
July 27, 2017: Journal of Nuclear Cardiology: Official Publication of the American Society of Nuclear Cardiology
https://www.readbyqxmd.com/read/28752130/design-analysis-of-an-mpi-human-functional-brain-scanner
#11
Erica E Mason, Clarissa Z Cooley, Stephen F Cauley, Mark A Griswold, Steven M Conolly, Lawrence L Wald
MPI's high sensitivity makes it a promising modality for imaging brain function. Functional contrast is proposed based on blood SPION concentration changes due to Cerebral Blood Volume (CBV) increases during activation, a mechanism utilized in fMRI studies. MPI offers the potential for a direct and more sensitive measure of SPION concentration, and thus CBV, than fMRI. As such, fMPI could surpass fMRI in sensitivity, enhancing the scientific and clinical value of functional imaging. As human-sized MPI systems have not been attempted, we assess the technical challenges of scaling MPI from rodent to human brain...
2017: Int J Magn Part Imaging
https://www.readbyqxmd.com/read/28751648/effects-of-ultrashort-laser-pulses-on-angular-distributions-of-photoionization-spectra
#12
C H Raymond Ooi, W L Ho, A D Bandrauk
We study the photoelectron spectra by intense laser pulses with arbitrary time dependence and phase within the Keldysh framework. An efficient semianalytical approach using analytical transition matrix elements for hydrogenic atoms in any initial state enables efficient and accurate computation of the photoionization probability at any observation point without saddle point approximation, providing comprehensive three dimensional photoelectron angular distribution for linear and elliptical polarizations, that reveal the intricate features and provide insights on the photoionization characteristics such as angular dispersions, shift and splitting of photoelectron peaks from the tunneling or above threshold ionization(ATI) regime to non-adiabatic(intermediate) and multiphoton ionization(MPI) regimes...
July 27, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28748241/spectral-dependence-of-photoemission-in-multiphoton-ionization-of-no2-by-femtosecond-pulses-in-the-375-430-nm-range
#13
S Marggi Poullain, R Cireasa, C Cornaggia, M Simon, T Marin, R Guillemin, J C Houver, R R Lucchese, D Dowek
We investigate the multiphoton ionization of NO2 using tunable (430-375 nm) femtosecond pulses and photoelectron-photoion coincidence momentum spectroscopy. In order to understand the complex electronic and nuclear photodynamics at play following absorption of three to five photons, we also report extended photoionization calculations using correlated targets and coupled channels. Exploring the multiphoton dissociative ionization (MPDI) and multiphoton ionization (MPI) processes over such a broad energy range enables us to lend further support to our work carried out around 400 nm of a femtosecond laser [S...
July 27, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/28740960/prognostic-factors-in-patients-with-acute-mesenteric-ischemia
#14
Doğan Yıldırım, Adnan Hut, Cihad Tatar, Turgut Dönmez, Muzaffer Akıncı, Mehmet Toptaş
OBJECTIVE: Acute mesenteric ischemia, one of the causes of acute abdominal pain due to occlusion of the superior mesenteric artery, has a fatal course as a result of intestinal necrosis. There is no specific laboratory test to diagnose acute mesenteric ischemia. The basis of treatment in cases of acute mesenteric ischemia is composed of early diagnosis, resection of intestinal sections with infarction, regulation of intestinal blood flow, second look laparotomy when required, and intensive care support...
2017: Turk J Surg
https://www.readbyqxmd.com/read/28740266/reproducibility-of-centric-relation-techniques-by-means-of-condyle-position-analysis
#15
Nikolina Holen Galeković, Vesna Fugošić, Vedrana Braut, Robert Ćelić
PURPOSE: The aim of this study was to determine the reproducibility of clinical centric relation (CR) registration techniques (bimanual manipulation, chin point guidance and Roth's method) by means of condyle position analysis. MATERIAL AND METHODS: Thirty two fully dentate asymptomatic subjects (16 female and 16 male) with normal occlusal relations (Angle class I) participated in the study (mean age, 22.6 ± 4.7 years). The mandibular position indicator (MPI) was used to analyze the three-dimensional (anteroposterior (ΔX), superoinferior (ΔZ), mediolateral (ΔY)) condylar shift generated by the difference between the centric relation position (CR) and the maximal intercuspation position (MI) observed in dental arches...
March 2017: Acta Stomatologica Croatica
https://www.readbyqxmd.com/read/28738191/comparison-of-dental-implant-performance-following-vertical-alveolar-bone-augmentation-with-alveolar-distraction-osteogenesis-or-autogenous-onlay-bone-grafts-a-retrospective-cohort-study
#16
Kai Zhao, Feng Wang, Wei Huang, Yiqun Wu
PURPOSE: The aim of this retrospective study was to compare the performance of implants placed after alveolar distraction osteogenesis (ADO) or autogenous onlay bone grafting (AOBG) based on implant survival, peri-implant bone resorption, and clinical parameters. MATERIALS AND METHODS: From February 2008 to July 2012, 17 patients (6 women and 11 men) with implant placement after ADO (group 1, n = 8) or AOBG (group 2, n = 9) were included in this retrospective study...
July 1, 2017: Journal of Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/28738105/psychosocial-and-behavioral-aspects-of-pain-and-perception-of-oral-health
#17
Miriane Lucindo Zucoloto, João Maroco, Juliana Alvares Campos
AIMS: To evaluate the contribution of the psychosocial and behavioral aspects of pain to the perception of oral health in a sample of Brazilian dental patients. METHODS: This cross-sectional study involved 436 patients who sought dental care in the School of Dentistry of São Paulo State University and who reported some type of orofacial pain. The study group's mean age (± standard deviation [SD]) was 39.9 ± 13.6 years, and the sample was 74.5% female. The Portuguese version of the Oral Health Impact Profile Short Form (OHIP-14) and the Multidimensional Pain Inventory (MPI) were used...
July 2017: Journal of Oral & Facial Pain and Headache
https://www.readbyqxmd.com/read/28726076/ejection-fraction-in-myocardial-perfusion-imaging-assessed-with-a-dynamic-phantom-comparison-between-iq-spect-and-lehr
#18
Eero Hippeläinen, Teemu Mäkelä, Touko Kaasalainen, Erna Kaleva
BACKGROUND: Developments in single photon emission tomography instrumentation and reconstruction methods present a potential for decreasing acquisition times. One of such recent options for myocardial perfusion imaging (MPI) is IQ-SPECT. This study was motivated by the inconsistency in the reported ejection fraction (EF) and left ventricular (LV) volume results between IQ-SPECT and more conventional low-energy high-resolution (LEHR) collimation protocols. IQ-SPECT and LEHR quantitative results were compared while the equivalent number of iterations (EI) was varied...
December 2017: EJNMMI Physics
https://www.readbyqxmd.com/read/28707268/-hey-we-are-the-best-ones-at-dealing-with-our-own-embedding-a-culturally-competent-program-for-m%C3%A4-ori-and-pacific-island-children-into-a-mainstream-health-service-in-queensland-australia
#19
Lisa Vaughan, Lisa Schubert, Helen Mavoa, Nicola Fa'avale
OBJECTIVE: We present the results of one component of an external evaluation of Good Start Program (GSP), a community-based program for the prevention of chronic disease among Maori and Pacific Island (MPI) communities living in the state of Queensland, Australia. DESIGN: An evaluation of the GSP was undertaken using a mixed methods approach. This paper reports on the qualitative component where interview and focus group data was collected, using Talanoa, a culturally tailored research methodology...
July 13, 2017: Journal of Racial and Ethnic Health Disparities
https://www.readbyqxmd.com/read/28706244/predicting-magnetostimulation-thresholds-in-the-peripheral-nervous-system-using-realistic-body-models
#20
Mathias Davids, Bastien Guérin, Matthias Malzacher, Lothar R Schad, Lawrence L Wald
Rapid switching of applied magnetic fields in the kilohertz frequency range in the human body induces electric fields powerful enough to cause Peripheral Nerve Stimulation (PNS). PNS has become one of the main constraints on the use of high gradient fields for fast imaging with the latest MRI gradient technology. In recent MRI gradients, the applied fields are powerful enough that PNS limits their application in fast imaging sequences like echo-planar imaging. Application of Magnetic Particle Imaging (MPI) to humans is similarly PNS constrained...
July 13, 2017: Scientific Reports
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