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https://www.readbyqxmd.com/read/29783054/application-of-indices-to-evaluate-lid-facilities-for-sediment-and-heavy-metal-removal
#1
Sher Bahadur Gurung, Franz Kevin Geronimo, Jungsun Hong, Lee-Hyung Kim
Heavy metal and sediments transported from the urban catchment are the prime interest among researchers these days due to its toxic behaviour and hazardous effect on the animals, plants and human. The inflow from urban catchments and outflow from the Low impact development technologies (LID) were evaluated using different types of indices. Indices like fd , fp and Kd showed that heavy metals like Pb, Cd and Ni were dominantly observed in the dissolved form. These metals possess higher threat to the water bodies receiving urban runoff without any treatments...
May 14, 2018: Chemosphere
https://www.readbyqxmd.com/read/29777704/dietary-mung-bean-protein-reduces-high-fat-diet-induced-weight-gain-by-modulating-host-bile-acid-metabolism-in-a-gut-microbiota-dependent-manner
#2
Akiho Nakatani, Xuan Li, Junki Miyamoto, Miki Igarashi, Hitoshi Watanabe, Asuka Sutou, Keita Watanabe, Takayasu Motoyama, Nobuhiko Tachibana, Mitsutaka Kohno, Hiroshi Inoue, Ikuo Kimura
The 8-globulin-rich mung bean protein (MPI) suppresses hepatic lipogenesis in rodent models and reduces fasting plasma glucose and insulin levels in obese adults. However, its effects on mitigating high fat diet (HFD)-induced obesity and the mechanism underlying these effects remain to be elucidated. Herein, we examined the metabolic phenotype, intestinal bile acid (BA) pool, and gut microbiota of conventionally raised (CONV-R) male C57BL/6 mice and germ-free (GF) mice that were randomized to receive either regular HFD or HFD containing mung bean protein isolate (MPI) instead of the dairy protein present in regular HFD...
May 16, 2018: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29777281/right-ventricular-systolic-function-parameters-in-hypoplastic-left-heart-syndrome
#3
S Javed Zaidi, Jamie Penk, Vivian W Cui, Supaluck Kanjanauthai, David A Roberson
Assessment of the systolic function of the right ventricle (RV) in patients with hypoplastic left heart syndrome (HLHS) is important. The asymmetric shape and heavy trabeculations make accurate assessment of RV systolic function challenging. Novel measures of RV function could be helpful in distinguishing reduced versus preserved function in HLHS and may also be worse in HLHS with preserved function compared to normal controls. These novel methods offer promise, but research and clinical applicability is hindered as no cut-off values for normal function have been established...
May 18, 2018: Pediatric Cardiology
https://www.readbyqxmd.com/read/29774406/reduced-global-myocardial-perfusion-reserve-in-dcm-and-hcm-patients-assessed-by-cmr-based-velocity-encoded-coronary-sinus-flow-measurements-and-first-pass-perfusion-imaging
#4
Michael Bietenbeck, Anca Florian, Zornitsa Shomanova, Claudia Meier, Ali Yilmaz
BACKGROUND: Coronary microvascular dysfunction (CMD) is an independent predictor of poor prognosis in patients suffering from dilative or hypertrophic cardiomyopathy (DCM/HCM). To assess CMD, quantitative myocardial first-pass perfusion (1P) cardiovascular magnetic resonance (CMR) can be performed. Coronary sinus flow (CSF) measurements at rest and during maximal vasodilatation are an alternative and well-validated approach for the quantification of global myocardial blood flow (MBF) in CMR...
May 17, 2018: Clinical Research in Cardiology: Official Journal of the German Cardiac Society
https://www.readbyqxmd.com/read/29770591/surf-an-innovative-framework-in-biosecurity-and-animal-health-surveillance-evaluation
#5
Petra Muellner, Jonathan Watts, Paul Bingham, Mark Bullians, Brendan Gould, Anjali Pande, Tim Riding, Paul Stevens, Daan Vink, Katharina Dc Stärk
Surveillance for biosecurity hazards is being conducted by the New Zealand Competent Authority, the Ministry for Primary Industries (MPI) to support New Zealand's biosecurity system. Surveillance evaluation should be an integral part of the surveillance life cycle, as it provides a means to identify and correct problems and to sustain and enhance the existing strengths of a surveillance system. The surveillance evaluation Framework (SurF) presented here was developed to provide a generic framework within which the MPI biosecurity surveillance portfolio, and all of its components, can be consistently assessed...
May 16, 2018: Transboundary and Emerging Diseases
https://www.readbyqxmd.com/read/29768319/contrast-enhanced-stress-echocardiography-and-myocardial-perfusion-imaging-in-patients-hospitalized-with-chest-pain-a-randomized-study
#6
Gerald Salame, Whitney E Juselius, Marisha Burden, Carlin S Long, Tiffany Bendelow, Brenda Beaty, Frederick A Masoudi, Mori J Krantz
Ultrasound contrast-enhanced stress echocardiography improves endocardial visualization, but diagnostic test rates versus stress myocardial perfusion imaging (MPI) have not been studied. A prospective randomized trial was performed between April 2012 and October 2014 at a single-center, safety net hospital. Hospitalized patients referred for noninvasive stress imaging were randomized 1:1 to stress echocardiography or stress MPI. The primary outcome was diagnostic test rate defined as interpretable images and achievement of >85% of age-predicted maximal heart rate (for dobutamine and exercise)...
June 2018: Critical Pathways in Cardiology
https://www.readbyqxmd.com/read/29763366/right-ventricle-performances-with-echocardiography-and-99m-tc-myocardial-perfusion-imaging-in-pulmonary-arterial-hypertension-patients
#7
Jie Liu, Lei Fei, Guang-Qing Huang, Xiao-Ke Shang, Mei Liu, Zhi-Jun Pei, Yong-Xue Zhang
Right heart catheterization is commonly used to measure right ventricle hemodynamic parameters and is the gold standard for pulmonary arterial hypertension diagnosis; however, it is not suitable for patients' long-term follow-up. Non-invasive echocardiography and nuclear medicine have been applied to measure right ventricle anatomy and function, but the guidelines for the usefulness of clinical parameters remain to be established. The goal of this study is to identify reliable clinical parameters of right ventricle function in pulmonary arterial hypertension patients and analyze the relationship of these clinical parameters with the disease severity of pulmonary arterial hypertension...
May 2018: Experimental Biology and Medicine
https://www.readbyqxmd.com/read/29762754/optimized-distributed-systems-achieve-significant-performance-improvement-on-sorted-merging-of-massive-vcf-files
#8
Xiaobo Sun, Jingjing Gao, Peng Jin, Celeste Eng, Esteban G Burchard, Terri H Beaty, Ingo Ruczinski, Rasika A Mathias, Kathleen C Barnes, Fusheng Wang, Zhaohui Qin
Background: Sorted merging of genomic data is a common data operation necessary in many sequencing-based studies. It involves sorting and merging genomic data from different subjects by their genomic locations. In particular, merging a large number of Variant Call Format (VCF) files is frequently required in large scale whole genome sequencing or whole exome sequencing projects. Traditional single machine based methods become increasingly inefficient when processing large numbers of VCF files due to the excessive computation time and I/O bottleneck...
May 11, 2018: GigaScience
https://www.readbyqxmd.com/read/29756358/echocardiographic-parameters-to-identify-sickle-cell-patients-with-cardio-pathology
#9
Simbo Chiadika, Mary Lim-Fung, Fiorella Llanos-Chea, Astrid Serauto Canache, Wei Yang, Christina Paruthi, Xu Zhang, David D McPherson, Modupe Idowu
BACKGROUND: Sickle cell disease (SCD) affects millions of people and causes chronic hemolytic anemia leading to vasculopathies such as pulmonary hypertension and abnormalities in cardiac function that increase complications and mortality. It is therefore crucial to identify cardiac abnormalities in SCD. We aimed to assess the prevalence of echocardiographic parameters in SCD to help identify cardiopulmonary risk. METHODS: Ninety-one patients (53% male), median age of 30, body surface area (BSA) of 1...
May 14, 2018: Echocardiography
https://www.readbyqxmd.com/read/29754007/magnetic-particle-imaging-for-radiation-free-sensitive-and-high-contrast-vascular-imaging-and-cell-tracking
#10
REVIEW
Xinyi Y Zhou, Zhi Wei Tay, Prashant Chandrasekharan, Elaine Y Yu, Daniel W Hensley, Ryan Orendorff, Kenneth E Jeffris, David Mai, Bo Zheng, Patrick W Goodwill, Steven M Conolly
Magnetic particle imaging (MPI) is an emerging ionizing radiation-free biomedical tracer imaging technique that directly images the intense magnetization of superparamagnetic iron oxide nanoparticles (SPIOs). MPI offers ideal image contrast because MPI shows zero signal from background tissues. Moreover, there is zero attenuation of the signal with depth in tissue, allowing for imaging deep inside the body quantitatively at any location. Recent work has demonstrated the potential of MPI for robust, sensitive vascular imaging and cell tracking with high contrast and dose-limited sensitivity comparable to nuclear medicine...
May 10, 2018: Current Opinion in Chemical Biology
https://www.readbyqxmd.com/read/29747119/experiencing-meditation-evidence-for-differential-effects-of-three-contemplative-mental-practices-in-micro-phenomenological-interviews
#11
Marisa Przyrembel, Tania Singer
Despite increasing interest in effects of meditation, systematic in-depth research on how it qualitatively feels to engage in different kinds of contemplative practices is still missing. To fill this gap, we explore the validity of Micro-phenomenological Interviews (MpI) to assess experiences during breathing meditation (BM), observing-thought meditation (OTM), and loving-kindness meditation (LKM). We performed psycholinguistic analyses, quantitative ratings and qualitative explorations of 104 MpI (N = 57)...
May 7, 2018: Consciousness and Cognition
https://www.readbyqxmd.com/read/29743901/effect-of-nicorandil-administration-on-myocardial-microcirculation-during-primary-percutaneous-coronary-intervention-in-patients-with-acute-myocardial-infarction
#12
Chunguang Feng, Bing Han, Yi Liu, Lulu Wang, Dongdong Niu, Ming Lou, Cunzhi Lu
Introduction: Prevention of the no-reflow phenomenon has a crucial role in primary percutaneous coronary intervention (P-PCI) procedures. Aim: To assess the effects of early intracoronary administration of nicorandil (NIC) during P-PCI on myocardial microcirculation in patients with acute myocardial infarction (AMI). Material and methods: A total of 120 patients with first acute anterior wall ST segment elevation myocardial infarction who underwent P-PCI were randomly divided into two groups: the NIC group (A, n = 60) and the placebo group (B, n = 60)...
2018: Postępy W Kardiologii Interwencyjnej, Advances in Interventional Cardiology
https://www.readbyqxmd.com/read/29740835/factors-associated-to-early-intrauterine-fetal-demise-after-laser-for-ttts-by-pre-operative-fetal-heart-and-doppler-ultrasound
#13
Amélie Delabaere, France Leduc, Quentin Reboul, Florent Fuchs, Sandrine Wavrant, Johanne Dubé, Jean-Claude Fouron, François Audibert
OBJECTIVE: To determine the prognostic value of fetal Doppler and echocardiographic parameters for intra-uterine fetal demise (IUFD) within 24 hours and within one week after laser coagulation in monochorionic pregnancies complicated by twin-twin transfusion syndrome (TTTS). METHOD: This retrospective study correlated the preoperative hemodynamic and echocardiography parameters to the outcome in fetuses with TTTS undergoing laser therapy. RESULTS: One hundred and twelve laser coagulations were performed between February 2006 and June 2015...
May 9, 2018: Prenatal Diagnosis
https://www.readbyqxmd.com/read/29739354/longitudinal-analysis-of-cardiac-structure-and-function-in-incident-automated-peritoneal-dialysis-comparison-between-icodextrin-solution-and-glucose-based-solution
#14
Jin-Bor Chen, Ben-Chung Cheng, Wen-Hao Liu, Shang-Chih Liao, Mao-Young Morgan Fu, Sin-Hua Moi, Cheng-Hong Yang
BACKGROUND: This study aimed to evaluate the longitudinal changes in cardiac structure and function in incident-automated peritoneal dialysis (APD) patients. METHODS: We conducted a 2-year prospective, randomized, open-label, parallel-group study to compare the efficacy of icodextrin solution versus glucose-based solution. Echocardiography was performed at baseline, 1 and 2 years. Echocardiographic parameters over 2 years were evaluated for each group, using the Friedman test...
May 8, 2018: BMC Nephrology
https://www.readbyqxmd.com/read/29738908/rodent-cerebral-blood-volume-cbv-changes-during-hypercapnia-observed-using-magnetic-particle-imaging-mpi-detection
#15
Clarissa Zimmerman Cooley, Joseph B Mandeville, Erica E Mason, Emiri T Mandeville, Lawrence L Wald
Magnetic Particle Imaging (MPI) is a rapidly developing imaging modality that directly measures and maps the concentration of injected superparamagnetic iron oxide nanoparticles (SPIOs). Since the agent does not cross the blood-brain barrier, cerebral SPIO concentration provides a direct probe of Cerebral Blood Volume (CBV). Here we provide an initial demonstration of the ability of MPI to detect functional CBV changes (fCBV) by monitoring SPIO concentration during hypercapnic manipulation in a rat model. As a tracer detection method, MPI offers a more direct probe of agent concentration and therefore fCBV than MRI measurements in which the agent is indirectly detected through perturbation of water relaxation time constants such as T2 ∗ ...
May 5, 2018: NeuroImage
https://www.readbyqxmd.com/read/29732110/tinker-hp-a-massively-parallel-molecular-dynamics-package-for-multiscale-simulations-of-large-complex-systems-with-advanced-point-dipole-polarizable-force-fields
#16
Louis Lagardère, Luc-Henri Jolly, Filippo Lipparini, Félix Aviat, Benjamin Stamm, Zhifeng F Jing, Matthew Harger, Hedieh Torabifard, G Andrés Cisneros, Michael J Schnieders, Nohad Gresh, Yvon Maday, Pengyu Y Ren, Jay W Ponder, Jean-Philip Piquemal
We present Tinker-HP, a massively MPI parallel package dedicated to classical molecular dynamics (MD) and to multiscale simulations, using advanced polarizable force fields (PFF) encompassing distributed multipoles electrostatics. Tinker-HP is an evolution of the popular Tinker package code that conserves its simplicity of use and its reference double precision implementation for CPUs. Grounded on interdisciplinary efforts with applied mathematics, Tinker-HP allows for long polarizable MD simulations on large systems up to millions of atoms...
January 28, 2018: Chemical Science
https://www.readbyqxmd.com/read/29727282/joint-reconstruction-of-tracer-distribution-and-background-in-magnetic-particle-imaging
#17
Marcel Straub, Volkmar Schulz
Magnetic particle imaging (MPI) is a novel tomographic imaging technique, which visualizes the distribution of a magnetic nanoparticle-based tracer material. However, reconstructed MPI images often suffer from an insufficiently compensated image background caused by rapid non-deterministic changes in the background signal of the imaging device. In particular, the signal-to-background ratio (SBR) of the images is reduced for lower tracer concentrations or longer acquisitions. The state-of-the-art procedure in MPI is to frequently measure the background signal during the sample measurement...
May 2018: IEEE Transactions on Medical Imaging
https://www.readbyqxmd.com/read/29725391/2d-sti-combined-with-gated-99tcm-mibi-mpi-for-the-diagnosis-of-myocardial-ischemia-in-hypercholesterolemia-patients
#18
Yi Song, Rui-Fang Zhang, Yu Liu
[This retracts the article DOI: 10.3892/etm.2017.4602.].
May 2018: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29720565/implementation-of-a-cardiac-pet-stress-program-comparison-of-outcomes-to-the-preceding-spect-era
#19
Stacey Knight, David B Min, Viet T Le, Kent G Meredith, Ritesh Dhar, Santanu Biswas, Kurt R Jensen, Steven M Mason, Jon-David Ethington, Donald L Lappe, Joseph B Muhlestein, Jeffrey L Anderson, Kirk U Knowlton
BACKGROUND: Cardiac positron emission testing (PET) is more accurate than single photon emission computed tomography (SPECT) at identifying coronary artery disease (CAD); however, the 2 modalities have not been thoroughly compared in a real-world setting. We conducted a retrospective analysis of 60-day catheterization outcomes and 1-year major adverse cardiovascular events (MACE) after the transition from a SPECT- to a PET-based myocardial perfusion imaging (MPI) program. METHODS: MPI patients at Intermountain Medical Center from January 2011-December 2012 (the SPECT era, n = 6,777) and January 2014-December 2015 (the PET era, n = 7,817) were studied...
May 3, 2018: JCI Insight
https://www.readbyqxmd.com/read/29716702/heart-rate-manipulation-in-dilated-cardiomyopathy-assessing-the-role-of-ivabradine
#20
Deep Chandh Raja, Aditya Kapoor, Archana Sinha, Shiridhar Kashyap, Roopali Khanna, Sudeep Kumar, Naveen Garg, Satyendra Tewari, Pravin Goel
BACKGROUND: Heart rate (HR) reduction is of benefit in chronic heart failure (HF). The effect of heart rate reduction using Ivabradine on various echocardiographic parameters in dilated cardiomyopathy has been less investigated. METHODS: Of 187 patients with HF (DCM, NYHA II-IV, baseline HR>70/min), 125 patients were randomized to standard therapy (beta blockers, ACEI, diuretics, n=62) or add-on Ivabradine (titrated to maximum 7.5mg BD, n=63). Beta-blockers were titrated in both the groups...
March 2018: Indian Heart Journal
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