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https://www.readbyqxmd.com/read/28315942/forgotten-right-ventricle-in-pediatric-dilated-cardiomyopathy
#1
Hala Mounir Agha, Hossam Ibrahim, Inas Abd El Satar, Naglae Abd El Rahman, Doaa Abd El Aziz, Zeinab Salah, Sonia El Saeidi, Fatma Mostafa, Wael Attia, Mohamed Abd El Rahman, Gaser Abd El Mohsen
To evaluate the right ventricular (RV) function in relation to that of the left ventricle (LV) in patients with dilated cardiomyopathy (DCM). Echocardiographic examination was done using tissue Doppler imaging (TDI) and two-dimensional speckle tracking echocardiography (2D-STE) for 32 pediatric patients with DCM comparing them to another 32 normal matched controls. The global longitudinal strain (GLS) derived from 2D-STE was used to reflect the LV systolic function. Tricuspid annular plan systolic excursion (TAPSE) and the following RV TDI derived indexes: peak systolic velocity (S'), peak early diastolic velocity E', peak late diastolic velocity A', isovolumic acceleration (IVA) and myocardial performance index (MPI) were measured...
March 18, 2017: Pediatric Cardiology
https://www.readbyqxmd.com/read/28306335/prognostic-value-of-normal-positron-emission-tomography-myocardial-perfusion-imaging-in-patients-with-known-or-suspected-coronary-artery-disease-a-meta-analysis
#2
A'Di Chen, HaoSen Wang, Bing Fan, YaWei Xu, Wei Chen, Neng Dai
OBJECTIVE: Several studies have confirmed high diagnostic performance of positron emission tomography (PET) myocardial perfusion imaging (MPI) in patients with known or suspected coronary artery disease (CAD). However, whether the superior diagnostic accuracy could translate into improved mortality outcomes remains unknown. The aim of this study was to define the prognostic value of normal PET MPI. METHODS: PubMed and EMBASE were searched to identify related studies up to June 2016...
March 17, 2017: British Journal of Radiology
https://www.readbyqxmd.com/read/28302319/high-sensitivity-cardiac-troponin-t-and-systemic-right-ventricular-function-in-adults-with-congenitally-corrected-transposition-of-the-great-arteries
#3
Ewa Kowalik, Anna Klisiewicz, Justyna Rybicka, Elżbieta K Biernacka, Piotr Hoffman
BACKGROUND: High sensitive troponin T (hsTnT), a marker of myocardial injury, appears to be a promising diagnostic tool in patients with congenital heart disease. However, little is known about its distribution among adults with systemic right ventricle (sRV). We aimed to assess the distribution of hsTnT concentrations in patients with congenitally corrected transposition of the great arteries (ccTGA) and to evaluate its relationship with sRV function and NT-proBNP. METHODS: A cross-sectional study of adults with ccTGA was conducted...
March 11, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/28295341/exercise-training-reverses-age-induced-diastolic-dysfunction-and-restores-coronary-microvascular-function
#4
Kazuki Hotta, Bei Chen, Bradley J Behnke, Payal Ghosh, John N Stabley, Jeremy A Bramy, Jaime L Sepulveda, Michael D Delp, Judy M Muller-Delp
The risk for diastolic dysfunction increases with advancing age. Regular exercise training ameliorates age-related diastolic dysfunction; however, the underlying mechanisms have not been identified. We investigated whether 1) microvascular dysfunction contributes to the development of age-related diastolic dysfunction, and 2) initiation of late-life exercise training reverses age-related diastolic and microvascular dysfunction. Young and old rats underwent 10 weeks of exercise training or remained as sedentary, cage-controls...
March 10, 2017: Journal of Physiology
https://www.readbyqxmd.com/read/28290371/release-of-dipeptidyl-peptidase-iv-dpp-iv-inhibitory-peptides-from-milk-protein-isolate-mpi-during-enzymatic-hydrolysis
#5
Alice B Nongonierma, Caterina Mazzocchi, Sara Paolella, Richard J FitzGerald
The release of dipeptidyl peptidase IV (DPP-IV) inhibitory peptides from bovine milk protein isolate (MPI) during trypsin hydrolysis was studied using a design of experiments (DOE) approach. A 3 factor×3 level DOE including temperature (40, 50 and 60°C), enzyme to substrate ratio (E:S; 0.50, 1.25 and 2.00% (w/w)) and hydrolysis time (60, 150 and 240min) was used during the generation of 15 hydrolysates (H1-H15). The degree of hydrolysis (DH) varied between 6.98±0.31 (H8) to 12.75±0.62% (H10). The DPP-IV half maximal inhibitory concentration (IC50) ranged from 0...
April 2017: Food Research International
https://www.readbyqxmd.com/read/28290100/triage-of-patients-for-attenuation-corrected-stress-first-tc-99m-spect-mpi-using-a-simplified-clinical-pre-test-scoring-model
#6
Shreyas Gowdar, Waseem Chaudhry, Alan W Ahlberg, Milena J Henzlova, W Lane Duvall
BACKGROUND: Stress-only Tc-99m SPECT MPI saves time and reduces radiation exposure while a normal study has a benign prognosis. However, no guidelines exist as to which patients should undergo stress-first MPI. The purpose of this study was to validate a previously published pre-test prediction scoring model and refine the stress-first triage process further if possible. METHODS: We retrospectively reviewed all patients who underwent an attenuation-corrected Tc-99m SPECT MPI over a 39-month period...
March 13, 2017: Journal of Nuclear Cardiology: Official Publication of the American Society of Nuclear Cardiology
https://www.readbyqxmd.com/read/28290099/fully-automated-analysis-of-attenuation-corrected-spect-for-the-long-term-prediction-of-acute-myocardial-infarction
#7
Manish Motwani, William D Leslie, Andrew L Goertzen, Yuka Otaki, Guido Germano, Daniel S Berman, Piotr J Slomka
BACKGROUND: Most prior studies assessing the prognostic value of SPECT myocardial perfusion imaging (MPI) have used semi-quantitative visual analysis. We assessed the feasibility of large-scale fully automated quantitative analysis of SPECT MPI to predict acute myocardial infarction (AMI). Additionally, we examined the impact of attenuation correction (AC) in automated strategies. METHODS AND RESULTS: 5960 patients underwent rest/stress SPECT MPI with AC. Left ventricular (LV) segmentation, contour QC check, and quantitation of stress and ischemic total perfusion deficit (sTPD, iTPD) were performed...
March 13, 2017: Journal of Nuclear Cardiology: Official Publication of the American Society of Nuclear Cardiology
https://www.readbyqxmd.com/read/28288383/effect-of-methoxy-group-position-on-biological-properties-of-18-f-labeled-benzyl-triphenylphosphonium-cations
#8
Shuting Chen, Zuoquan Zhao, Ying Zhang, Wei Fang, Jie Lu, Xianzhong Zhang
INTRODUCTION: (18)F-labeled phosphonium cations targeting mitochondrial membrane potential would be promising for positron emission tomography (PET) myocardial perfusion imaging (MPI). The purpose of this study was to examine the influence of additional methoxy group and its different positions on myocardium uptake and pharmacokinetics properties of (18)F-labeled benzyl triphenylphosphonium cations. METHOD: In this study, three novel (18)F-labeled phosphonium cations, [(18)F]4-(fluoromethyl)benzyltris(4-methoxyphenyl) phosphonium cation (1b), [(18)F]4-(fluoromethyl)benzyltris(2-methoxyphenyl) phosphonium cation (2b) and [(18)F]4-(fluoromethyl)benzyltris(3-methoxyphenyl) phosphonium cation (3b), were efficiently prepared by a One-Pot method starting from the substitution of non-carried-added fluoride-18...
February 24, 2017: Nuclear Medicine and Biology
https://www.readbyqxmd.com/read/28287965/interactive-magnetic-catheter-steering-with-3d-real-time-feedback-using-multi-color-magnetic-particle-imaging
#9
Jurgen Rahmer, Daniel Wirtz, Claas Bontus, Joern Borgert, Bernhard Gleich
method that enables sensitive and fast imaging. It does not require ionizing radiation and thus may be a safe alternative for tracking of devices in the catheterization laboratory. The 3D real-time imaging capabilities of MPI have been demonstrated in vivo and recent improvements in fast online image reconstruction enable almost real-time data reconstruction and visualization. Moreover, based on the use of different magnetic particle types for catheter visualization and blood pool imaging, multi-color MPI enables reconstruction of separate images for the catheter and the vessels from simultaneously measured data...
March 7, 2017: IEEE Transactions on Medical Imaging
https://www.readbyqxmd.com/read/28281088/prognostic-impact-of-myocardial-perfusion-single-photon-emission-computed-tomography-in-patients-with-major-extracardiac-findings-by-computed-tomography-for-attenuation-correction
#10
Charline Zadro, Noé Roussel, Emmanuelle Cassol, Pierre Pascal, Antoine Petermann, Olivier Meyrignac, Marion Jaffro, Pauline Fournier, Maxime Cournot, Michel Galinier, Didier Carrié, Hervé Rousseau, Isabelle Berry, Olivier Lairez
BACKGROUND: Attenuation correction computed tomography (CT) contributes to an improvement in the diagnostic accuracy of myocardial perfusion imaging (MPI) by single photon emission tomography (SPECT). The aim of this study was to explore the prognosis of patients with major findings by CT according to the results of MPI. METHODS AND RESULTS: 1506 patients who underwent MPI by SPECT were retrospectively included. Attenuation correction CT images were systematically analyzed for major and minor abnormalities...
March 9, 2017: Journal of Nuclear Cardiology: Official Publication of the American Society of Nuclear Cardiology
https://www.readbyqxmd.com/read/28276752/new-solid-state-cadmium-zinc-telluride-technology-for-cardiac-single-photon-emission-computed-tomographic-myocardial-perfusion-imaging
#11
REVIEW
Ali B Alenazy, R Glenn Wells, Terrence D Ruddy
Single photon emission computed tomography (SPECT) myocardial perfusion imaging (MPI) is well established as diagnostic test for patients with suspected or known coronary artery disease. New camera systems have been developed with cadmium-zinc-telluride (CZT) detectors, novel collimator designs and reconstruction software. Areas covered: We review the current state of cardiac SPECT, advances in conventional camera technology and the development and clinical validation of solid-state CZT cameras. Expert commentary: The development of CZT systems is timely and addresses current issues for clinical SPECT imaging...
March 2017: Expert Review of Medical Devices
https://www.readbyqxmd.com/read/28270281/application-of-the-low-dose-one-stop-shop-cardiac-ct-protocol-with-third-generation-dual-source-ct
#12
Lu Lin, Yining Wang, Yan Yi, Jian Cao, Lingyan Kong, Hao Qian, Hongzhi Zhang, Wei Wu, Yun Wang, Zhengyu Jin
Objective To evaluate the feasibility of a low-dose one-stop-shop cardiac CT imaging protocol with third-generation dual-source CT (DSCT). Methods Totally 23 coronary artery disease (CAD) patients were prospectively enrolled between March to September in 2016. All patients underwent an ATP stress dynamic myocardial perfusion imaging (MPI) (data acquired prospectively ECG-triggered during end systole by table shuttle mode in 32 seconds) at 70 kV combined with prospectively ECG-triggered high-pitch coronary artery angiography (CCTA) on a third-generation DSCT system...
February 20, 2017: Zhongguo Yi Xue Ke Xue Yuan Xue Bao. Acta Academiae Medicinae Sinicae
https://www.readbyqxmd.com/read/28262908/relationship-between-myocardial-performance-index-and-severity-of-coronary-artery-disease-in-patients-with-non-st-segment-elevation-acute-coronary-syndrome
#13
Okay Abaci, Cuneyt Kocas, Veysel Oktay, Sukru Arslan, Yusuf Turkmen, Cem Bostan, Ugur Coskun, Ahmet Yildiz, Murat Ersanli
OBJECTIVES: We aimed to investigate the relationship between myocardial performance index (MPI) and severity of coronary artery disease, as assessed by the Gensini score (GS), in patients with non-ST-segment elevation myocardial infarction (NSTEMI). METHODS: Ninety patients with an initial diagnosis of NSTEMI were enrolled in our study. They were divided into tertiles according to the GS: low GS < 19; mid GS > 19 and ≤ 96; and high GS > 96. RESULTS: The low-, mid- and high-GS groups included 24, 38 and 28 patients, respectively...
January 2017: Cardiovascular Journal of Africa
https://www.readbyqxmd.com/read/28256245/effects-of-medially-posted-insoles-on-foot-and-lower-limb-mechanics-across-walking-and-running-in-overpronating-men
#14
Jukka Kosonen, Juha-Pekka Kulmala, Erich Müller, Janne Avela
Anti-pronation orthoses, like medially posted insoles (MPI), have traditionally been used to treat various of lower limb problems. Yet, we know surprisingly little about their effects on overall foot motion and lower limb mechanics across walking and running, which represent highly different loading conditions. To address this issue, multi-segment foot and lower limb mechanics was examined among 11 overpronating men with normal (NORM) and MPI insoles during walking (self-selected speed 1.70±0.19m/s vs 1.72±0...
February 6, 2017: Journal of Biomechanics
https://www.readbyqxmd.com/read/28252227/meta-analysis-of-the-energy-and-protein-requirements-of-hair-sheep-raised-in-the-tropical-region-of-brazil
#15
A P Oliveira, E S Pereira, S Biffani, A N Medeiros, A M A Silva, R L Oliveira, M I Marcondes
The objective of this study was to estimate, through mathematical models, energy and protein requirements for maintenance and gain of hair sheep raised in the tropical region of Brazil. To determine the equation parameters, a meta-analysis of seven independent experiments of nutrient requirements was performed, comprising a total of 243 experimental units (animals), which were conducted under tropical conditions, using hair sheep in growing and finishing phases and endowed of the following quantitative data for each animal: body weight (BW), empty body weight (EBW), average daily gain (ADG), empty body gain (EBG), heat production (HP), metabolizable energy intake (MEI), retained energy (RE), metabolizable protein intake (MPI) and body protein content...
March 2, 2017: Journal of Animal Physiology and Animal Nutrition
https://www.readbyqxmd.com/read/28243726/short-term-effects-of-air-quality-and-thermal-stress-on-non-accidental-morbidity-a-multivariate-meta-analysis-comparing-indices-to-single-measures
#16
Hanna Leona Lokys, Jürgen Junk, Andreas Krein
Air quality and thermal stress lead to increased morbidity and mortality. Studies on morbidity and the combined impact of air pollution and thermal stress are still rare. To analyse the correlations between air quality, thermal stress and morbidity, we used a two-stage meta-analysis approach, consisting of a Poisson regression model combined with distributed lag non-linear models (DLNMs) and a meta-analysis investigating whether latitude or the number of inhabitants significantly influence the correlations...
February 28, 2017: International Journal of Biometeorology
https://www.readbyqxmd.com/read/28242975/radio-adaptive-response-in-myocardial-perfusion-imaging-induced-by-technetium-99m
#17
Mohammad Mehdi Shirazi, Ali Shabestani-Monfared, Maryam Shahidi, Mehrangiz Amiri, Seyed Mohammad Abedi, Sajad Borzoueisileh, Kourosh Ebrahim Nejad Gorji
PURPOSE OF THE STUDY: Low dose radiation will induce adaptation and following exposure to an adaptive dose, the cells are more resistance to following challenging doses. This phenomenon is known as radio-adaptive response. The aim of this study was to investigate the percentage of apoptotic cells in the peripheral blood samples of the patients which undergo myocardial perfusion imaging (MPI) with technetium-99m (Tc-99m) before thallium scan to assess the induction of radio-adaptive response...
January 2017: Indian Journal of Nuclear Medicine: IJNM: the Official Journal of the Society of Nuclear Medicine, India
https://www.readbyqxmd.com/read/28240684/left-ventricular-myocardial-performance-index-in-prehypertensive-patients-with-normal-coronary-arteries
#18
Erdoğan Yaşar, Hakan Taşolar, Nusret Açikgöz
OBJECTIVES: Prehypertension, which may be the precursor of hypertension, is an important public health problem in the community. Myocardial performance index (MPI) is a noninvasive Doppler measurement of global ventricular function. Thus, our aim was to evaluate left ventricule (LV) functions with the MPI in prehypertensive patients with normal coronary artery angiography. PATIENTS AND MATERIALS: Forty prehypertensive patients (21 women and 19 men), with blood pressures between 120/80 and 139/89 mmHg, and 40 normotensive controls (18 women and 22 men), with blood pressures under 120/80 mmHg, were included in the study...
February 24, 2017: Blood Pressure Monitoring
https://www.readbyqxmd.com/read/28239346/parallel-steps-large-scale-stochastic-spatial-reaction-diffusion-simulation-with-high-performance-computers
#19
Weiliang Chen, Erik De Schutter
Stochastic, spatial reaction-diffusion simulations have been widely used in systems biology and computational neuroscience. However, the increasing scale and complexity of models and morphologies have exceeded the capacity of any serial implementation. This led to the development of parallel solutions that benefit from the boost in performance of modern supercomputers. In this paper, we describe an MPI-based, parallel operator-splitting implementation for stochastic spatial reaction-diffusion simulations with irregular tetrahedral meshes...
2017: Frontiers in Neuroinformatics
https://www.readbyqxmd.com/read/28238508/using-a-multidimensional-prognostic-index-mpi-based-on-comprehensive-geriatric-assessment-cga-to-predict-mortality-in-elderly-undergoing-transcatheter-aortic-valve-implantation
#20
Marie-Laure Bureau, Evelyne Liuu, Luc Christiaens, Alberto Pilotto, Jean Mergy, Fabienne Bellarbre, Pierre Ingrand, Marc Paccalin
BACKGROUND: Selection of appropriate elderly who can benefit from transcatheter aortic valve implantation (TAVI) is challenging. We evaluated the prognosis of this procedure according to the comprehensive geriatric assessment (CGA) based on the multidimensional prognostic index (MPI). METHODS: Prospective observational monocentric study from January 2013 to December 2015. Consecutive patients aged ≥75 who underwent TAVI and a complete CGA were included. Baseline demographic, geriatric and cardiologic data were collected...
February 16, 2017: International Journal of Cardiology
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