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https://www.readbyqxmd.com/read/29159224/data-on-iron-oxide-core-oil-in-water-nanoemulsions-for-atherosclerosis-imaging
#1
Geoffrey Prévot, Stéphane Mornet, Cyril Lorenzato, Tina Kauss, Laurent Adumeau, Alexandra Gaubert, Julie Baillet, Philippe Barthélémy, Gisèle Clofent-Sanchez, Sylvie Crauste-Manciet
The data presented in this article are related to the publication entitled "Iron oxide core oil-in-water nanoemulsion as tracer for atherosclerosis MPI and MRI imaging" (Prévot et al., 2017) [1]. Herein we describe the synthesis and the characteristics of the Superparamagnetic Iron Oxide Nanoparticles (SPION) loaded inside nanoemulsions (NEs). Focus was set on obtaining SPION with narrow size distribution and close to superparamagnetic limit (20 nm) in order to reach a reasonable magnetic signal. Nanoparticles (NPs) of three different sizes were obtained (7, 11 and 18 nm) and characterized using transmission electron microscopy (TEM), X-ray diffraction (XRD), vibrating sample magnetometer (VSM), diffuse reflectance infrared Fourier transform (DRIFT) and thermogravimetric analysis (TGA)...
December 2017: Data in Brief
https://www.readbyqxmd.com/read/29159220/data-on-atherosclerosis-specific-antibody-conjugation-to-nanoemulsions
#2
Geoffrey Prévot, Martine Duonor-Cérutti, Mélusine Larivière, Jeanny Laroche-Traineau, Marie Josée Jacobin-Valat, Philippe Barthélémy, Gisèle Clofent-Sanchez, Sylvie Crauste-Manciet
This article present data related to the publication entitled "Iron oxide core oil-in-water nanoemulsion as tracer for atherosclerosis MPI and MRI imaging" (Prévot et al., 2017) [1]. Herein we describe the engineering in the baculovirus-insect cell system and purification processes of the human scFv-Fc TEG4-2C antibody, specific of platelets within the atheroma plaque. For molecular targeting purpose, atheroma specific antibody was conjugated to nanoemulsions (NEs) using a heterobifunctional linker (DSPE-PEG-maleimide)...
December 2017: Data in Brief
https://www.readbyqxmd.com/read/29132252/association-between-fetal-myocardial-performance-index-and-fetal-heart-rate-monitoring-a-prospective-observational-cohort-study
#3
Alexis C Gimovsky, Brianne Whitney, Dennis Wood, Stuart Weiner
OBJECTIVE: To evaluate whether the left myocardial performance index (MPI) changes in association with the fetal heart rate (FHR) tracing during labor. STUDY DESIGN: Women with term, singleton pregnancies, in labor were recruited to this prospective cohort study. PRIMARY OUTCOME: difference in left MPI between Category of fetal heart rate tracings. SECONDARY OUTCOMES: differences in left MPI by FHR characteristics. Participants underwent ultrasound examination, during which fetal MPI was measured...
November 13, 2017: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/29124673/failure-to-accurately-identify-the-number-of-diseased-coronary-arteries-a-weakness-of-spect-mpi
#4
EDITORIAL
Dennis A Calnon
No abstract text is available yet for this article.
November 9, 2017: Journal of Nuclear Cardiology: Official Publication of the American Society of Nuclear Cardiology
https://www.readbyqxmd.com/read/29124630/effectiveness-of-inspiratory-muscle-training-on-sleep-and-functional-capacity-to-exercise-in-obstructive-sleep-apnea-a-randomized-controlled-trial
#5
Adília Karoline Ferreira Souza, Armèle Dornelas de Andrade, Ana Irene Carlos de Medeiros, Maria Inês Remígio de Aguiar, Taciano Dias de Souza Rocha, Rodrigo Pinto Pedrosa, Anna Myrna Jaguaribe de Lima
PURPOSE: The aim of this study was to evaluate the effectiveness of inspiratory muscle training (IMT) on sleep and functional capacity to exercise in subjects with obstructive sleep apnea (OSA). METHODS: This is a controlled, randomized, double-blind study conducted in 16 OSA patients divided into two groups: training (IMT: n = 8) and placebo-IMT (P-IMT: n = 8). IMT was conducted during 12 weeks with a moderate load (50-60% of maximal inspiratory pressure-MIP), while P-IMT used a load < 20% of MPI...
November 9, 2017: Sleep & Breathing, Schlaf & Atmung
https://www.readbyqxmd.com/read/29116562/prediction-of-long-term-%C3%A2-10%C3%A2-year-cardiovascular-outcomes-in-heart-transplant-recipients-value-of-stress-technetium-99m-tetrofosmin-myocardial-perfusion-imaging
#6
Jesse F Veenis, Hendrik J Boiten, Jan C van den Berge, Kadir Caliskan, Alex P W M Maat, Roelf Valkema, Alina A Constantinescu, Olivier C Manintveld, Felix Zijlstra, Ron T van Domburg, Arend F L Schinkel
BACKGROUND: Myocardial perfusion imaging (MPI) using single-photon emission computed tomography (SPECT) is useful in the evaluation of cardiac allograft vasculopathy (CAV) in heart transplant (HTx) recipients. The current study evaluated the long-term prognostic value of stress SPECT MPI for predicting all-cause mortality and cardiac events in HTx recipients. METHODS: The study population consisted of 166 HTx recipients (mean age 54 ± 10 years, 84% male) who underwent exercise or dobutamine stress (99m)Tc-tetrofosmin SPECT MPI for the assessment of CAV...
November 7, 2017: Journal of Nuclear Cardiology: Official Publication of the American Society of Nuclear Cardiology
https://www.readbyqxmd.com/read/29112118/nutritional-therapies-in-congenital-disorders-of-glycosylation-cdg
#7
REVIEW
Peter Witters, David Cassiman, Eva Morava
Congenital disorders of glycosylation (CDG) are a group of more than 130 inborn errors of metabolism affecting N-linked, O-linked protein and lipid-linked glycosylation. The phenotype in CDG patients includes frequent liver involvement, especially the disorders belonging to the N-linked protein glycosylation group. There are only a few treatable CDG. Mannose-Phosphate Isomerase (MPI)-CDG was the first treatable CDG by high dose mannose supplements. Recently, with the successful use of d-galactose in Phosphoglucomutase 1 (PGM1)-CDG, other CDG types have been trialed on galactose and with an increasing number of potential nutritional therapies...
November 7, 2017: Nutrients
https://www.readbyqxmd.com/read/29112006/modified-lumbosacral-angle-and-modified-pelvic-incidence-as-new-parameters-for-management-of-pediatric-high-grade-spondylolisthesis
#8
Zhenjiang Ma, Changqing Zhao, Kai Zhang, Lin Du, Jianping Tian, Xiaojiang Sun, Jie Zhao
STUDY DESIGN: Retrospective clinical study. OBJECTIVE: We aimed to introduce new parameters that can better describe the pelvic morphology and lumbosacral segmental deformity in children with high-grade spondylolisthesis of the L5 vertebra: modified pelvic incidence (mPI) and modified lumbosacral angle (mLSA). Also, we aimed to establish the mLSA as a convenient, reliable measurement method and criteria to evaluate the reduction of L5 vertebral slippage. SUMMARY OF BACKGROUND DATA: Numerous parameters and methods exist to evaluate segmental deformity and reduction of L5 vertebral slippage, but no definitive standard for accurately and conveniently describing lumbosacral kyphosis and degree of reduction exists...
November 3, 2017: Clinical Spine Surgery
https://www.readbyqxmd.com/read/29107010/combining-high-sensitivity-cardiac-troponin-and-b-type-natriuretic-peptide-in-the-detection-of-inducible-myocardial-ischemia
#9
Christian Puelacher, Max Wagener, Ursina Honegger, Mustafa Assadian, Nicolas Schaerli, Deborah Mueller, Ivo Strebel, Raphael Twerenbold, Jasper Boeddinghaus, Thomas Nestelberger, Karin Wildi, Zaid Sabti, Lorraine Sazgary, Patrick Badertscher, Jeanne du Fay de Lavallaz, Stella Marbot, Christoph Kaiser, Damian Wild, Michael J Zellweger, Tobias Reichlin, Christian Mueller
BACKGROUND: Single biomarker approaches provide only moderate accuracy in the non-invasive detection of exercise-induced myocardial ischemia. We therefore assessed the combination of the two most promising single biomarkers: high-sensitivity cardiac troponin I (hs-cTnI) and B-type natriuretic peptide (BNP). METHODS: Consecutive patients with suspected myocardial ischemia referred to stress myocardial perfusion single-photon emission tomography imaging (MPI) were enrolled...
November 8, 2017: Clinical Biochemistry
https://www.readbyqxmd.com/read/29104303/gpu-accelerated-red-blood-cells-simulations-with-transport-dissipative-particle-dynamics
#10
Ansel L Blumers, Yu-Hang Tang, Zhen Li, Xuejin Li, George E Karniadakis
Mesoscopic numerical simulations provide a unique approach for the quantification of the chemical influences on red blood cell functionalities. The transport Dissipative Particles Dynamics (tDPD) method can lead to such effective multiscale simulations due to its ability to simultaneously capture mesoscopic advection, diffusion, and reaction. In this paper, we present a GPU-accelerated red blood cell simulation package based on a tDPD adaptation of our red blood cell model, which can correctly recover the cell membrane viscosity, elasticity, bending stiffness, and cross-membrane chemical transport...
August 2017: Computer Physics Communications
https://www.readbyqxmd.com/read/29104275/factors-associated-with-male-partner-involvement-in-programs-for-the-prevention-of-mother-to-child-transmission-of-hiv-in-rural-south-africa
#11
Motlagabo G Matseke, Robert A C Ruiter, Violeta J Rodriguez, Karl Peltzer, Geoffrey Setswe, Sibusiso Sifunda
Male partner involvement (MPI) can contribute to the success of programs aimed at preventing mother-to-child transmission (PMTCT) of HIV. However, the definition and measures of MPI differ according to context. This study utilized secondary cross-sectional data to investigate the prevalence and determinants of MPI among 463 male partners of HIV-infected pregnant women in rural South Africa. Results indicated that 44.1% of male partners reported involvement in most or all specified male partner involvement activities (i...
November 1, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/29103088/left-ventricular-functions-in-children-with-newly-diagnosed-graves-disease-a-single-center-study-from-upper-egypt
#12
Kotb Abbass Metwalley, Hekma Saad Farghaly, Abdelrahman Abdelhamid
This study aimed to evaluate the left ventricular (LV) functions in a cohort of children with Graves' disease (GD). This is a cross-sectional case-control study. It included 36 children with GD and 36 healthy children matched for age and gender. Thyroid hormones (TSH, FT4, and FT3) and anti-thyroid autoantibodies [anti-thyroid peroxidase (anti-TPO), thyrotropin receptor (TRAbs), and thyroglobulin antibodies] were measured. Conventional and tissue Doppler imaging (TDI) echocardiographies were used to assess left ventricular systolic and diastolic functions...
November 4, 2017: European Journal of Pediatrics
https://www.readbyqxmd.com/read/29100493/k-mer-clustering-algorithm-using-a-mapreduce-framework-application-to-the-parallelization-of-the-inchworm-module-of-trinity
#13
Chang Sik Kim, Martyn D Winn, Vipin Sachdeva, Kirk E Jordan
BACKGROUND: De novo transcriptome assembly is an important technique for understanding gene expression in non-model organisms. Many de novo assemblers using the de Bruijn graph of a set of the RNA sequences rely on in-memory representation of this graph. However, current methods analyse the complete set of read-derived k-mer sequence at once, resulting in the need for computer hardware with large shared memory. RESULTS: We introduce a novel approach that clusters k-mers as the first step...
November 3, 2017: BMC Bioinformatics
https://www.readbyqxmd.com/read/29098593/advanced-scoring-method-of-eco-efficiency-in-european-cities
#14
Victor Moutinho, Mara Madaleno, Margarita Robaina, José Villar
This paper analyzes a set of selected German and French cities' performance in terms of the relative behavior of their eco-efficiencies, computed as the ratio of their gross domestic product (GDP) over their CO2 emissions. For this analysis, eco-efficiency scores of the selected cities are computed using the data envelopment analysis (DEA) technique, taking the eco-efficiencies as outputs, and the inputs being the energy consumption, the population density, the labor productivity, the resource productivity, and the patents per inhabitant...
November 3, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/29094297/prognostic-accuracy-of-myocardial-perfusion-imaging-in-octogenarians
#15
Francesco Nudi, Giuseppe Biondi-Zoccai, Orazio Schillaci, Natale di Belardino, Francesco Versaci, Alessandro Nudi, Annamaria Pinto, Giandomenico Neri, Enrica Procaccini, Giacomo Frati, Ami E Iskandrian
BACKGROUND: Myocardial perfusion imaging (MPI) has an established role in the work-up of coronary artery disease (CAD), but its comparative accuracy is debated in elderly patients. We examined a large administrative database to appraise the performance of MPI in octogenarians. METHODS: Our institutional database was queried for patients undergoing MPI without recent coronary revascularization or myocardial infarction (MI). We compared baseline, procedural, diagnostic, and prognostic features in patients aged < 80 vs ≥ 80 years with bivariate and propensity-adjusted analyses...
November 1, 2017: Journal of Nuclear Cardiology: Official Publication of the American Society of Nuclear Cardiology
https://www.readbyqxmd.com/read/29077165/role-of-secreted-protein-acidic-in-hematogenous-metastasis-of-gastric-cancer
#16
A Mo, S-W Yang, Y-X Jiang, Y-L Zhao, Y Shi, F Qian, Y-X Hao, P-W Yu
OBJECTIVE: To investigate tumor microenvironment of metastasis (TMEM) and the expression of SPARC (secreted protein acidic and rich in cysteine) in gastric cancer, and their relationships with hematogenous metastasis. PATIENTS AND METHODS: Twenty-six pairs of cases with gastric cancer were enrolled, in which there were 26 cases with distant organ metastases and 26 cases of gastric cancer without organ metastases as controls. TMEM (by double-stained immunohistochemistry) and the expression of SPARC were determined in twenty-six pairs of cases...
October 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/29063953/magnetic-resonance-myocardial-perfusion-imaging-safety-and-indications-in-pediatrics-and-young-adults
#17
David M Biko, R Thomas Collins, Sara L Partington, Matthew Harris, Kevin K Whitehead, Marc S Keller, Mark A Fogel
The purpose of this study was to assess the safety and indications for cardiac magnetic resonance (CMR) with myocardial perfusion imaging (MPI) in a cohort of children and young adults. A retrospective review of 178 children and young adults who underwent CMR with MPI was performed. Studies were categorized based on study protocols as MPI with resting perfusion only, adenosine stress MPI, exercise-induced stress MPI, and MPI for cardiac mass diagnosis. Relevant clinical history, exam indications, and adverse reactions following gadolinium-based contrast agent and adenosine administration were recorded...
October 24, 2017: Pediatric Cardiology
https://www.readbyqxmd.com/read/29055639/prognostic-value-of-combined-clinical-and-myocardial-perfusion-imaging-data-using-machine-learning
#18
Julian Betancur, Yuka Otaki, Manish Motwani, Mathews B Fish, Mark Lemley, Damini Dey, Heidi Gransar, Balaji Tamarappoo, Guido Germano, Tali Sharir, Daniel S Berman, Piotr J Slomka
OBJECTIVES: This study evaluated the added predictive value of combining clinical information and myocardial perfusion single-photon emission computed tomography (SPECT) imaging (MPI) data using machine learning (ML) to predict major adverse cardiac events (MACE). BACKGROUND: Traditionally, prognostication by MPI has relied on visual or quantitative analysis of images without objective consideration of the clinical data. ML permits a large number of variables to be considered in combination and at a level of complexity beyond the human clinical reader...
October 16, 2017: JACC. Cardiovascular Imaging
https://www.readbyqxmd.com/read/29054082/ecological-risk-assessment-of-coastal-ecosystems-the-case-of-mangrove-forests-in-hormozgan-province-iran
#19
Saber Ghasemi, Sina Siavash Moghaddam, Amir Rahimi, Christos A Damalas, Abolfazl Naji
Sediment quality of mangrove forests in Hormozgan Province of Iran with a focus on two distinct habitats - the Hara Protected Area and the area of the Azini Bay - was studied. The accumulation of heavy metals in the sediments of the Hara Protected Area in terms of concentration was in the order of Pb > Zn > Cu > Cd and in those of the Azini Bay in the order of Zn > Cu > Pb > Cd. Based on Pearson's correlation coefficient, no significant correlations were found between concentrations of heavy metals in the sediments of the Hara Protected Area, while Zn and Pb concentrations were positively correlated in the sediments of the Azini Bay, implying a common pollution source...
October 9, 2017: Chemosphere
https://www.readbyqxmd.com/read/29043556/incidence-of-atrioventricular-block-with-vasodilator-stress-spect-a-meta-analysis
#20
Efstathia Andrikopoulou, Charity J Morgan, Lizbeth Brice, Navkaranbir S Bajaj, Harish Doppalapudi, Ami E Iskandrian, Fadi G Hage
BACKGROUND: Adenosine or regadenoson are often used with pharmacologic stress testing. Adenosine may trigger atrioventricular block (AVB). Despite its higher selectivity, regadenoson has also been associated with AVB. We studied the incidence of de novo AVB with these agents. METHODS: A comprehensive search of SCOPUS was performed from inception to March 2016. Studies of at least 10 patients, using adenosine and/or regadenoson with SPECT-MPI, reporting rates of AVB were selected for further review...
October 17, 2017: Journal of Nuclear Cardiology: Official Publication of the American Society of Nuclear Cardiology
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