Nathan W Churchill, Eugenie Roudaia, J Jean Chen, Allison Sekuler, Fuqiang Gao, Mario Masellis, Benjamin Lam, Ivy Cheng, Chris Heyn, Sandra E Black, Bradley J MacIntosh, Simon J Graham, Tom A Schweizer
Post-acute COVID syndrome (PACS) is a global health concern and is often associated with debilitating symptoms. Post-COVID fatigue is a particularly frequent and troubling issue, and its underlying mechanisms remain incompletely understood. One potential contributor is micropathological injury of subcortical and brainstem structures, as has been identified in other patient populations. Texture-based analysis (TA) may be used to measure such changes in anatomical MRI data. The present study develops a methodology of voxel-wise TA mapping in subcortical and brainstem regions, which is then applied to T1-weighted MRI data from a cohort of 48 individuals who had PACS (32 with and 16 without ongoing fatigue symptoms) and 15 controls who had cold and flu-like symptoms but tested negative for COVID-19...
May 9, 2024: Behavioural Brain Research