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Dopamine and memory

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https://www.readbyqxmd.com/read/27914942/is-there-a-role-for-ghrelin-in-central-dopaminergic-systems-focus-on-nigrostriatal-and-mesocorticolimbic-pathways
#1
REVIEW
Alicia Stievenard, Mathieu Méquinion, Zane B Andrews, Alain Destée, Marie-Christine Chartier-Harlin, Odile Viltart, Christel C Vanbesien-Mailliot
The gastro-intestinal peptide ghrelin has been assigned many functions. These include appetite regulation, energy metabolism, glucose homeostasis, intestinal motility, anxiety, memory or neuroprotection. In the last decade, this pleiotropic peptide has been proposed as a therapeutic agent in gastroparesis for diabetes and in cachexia for cancer. Ghrelin and its receptor, which is expressed throughout the brain, play an important role in motivation and reward. Ghrelin finely modulates the mesencephalic dopaminergic signaling and is thus currently studied in pathological conditions including dopamine-related disorders...
November 30, 2016: Neuroscience and Biobehavioral Reviews
https://www.readbyqxmd.com/read/27912164/manganese-ii-chloride-alters-behavioral-and-neurochemical-parameters-in-larvae-and-adult-zebrafish
#2
Stefani Altenhofen, Melissa Talita Wiprich, Laura Roesler Nery, Carlos Eduardo Leite, Monica Ryff Moreira Roca Vianna, Carla Denise Bonan
Manganese (Mn) is an essential metal for organisms, but high levels can cause serious neurological damage. The aim of this study was to evaluate the effects of MnCl2 exposure on cognition and exploratory behavior in adult and larval zebrafish and correlate these findings with brain accumulation of Mn, overall brain tyrosine hydroxylase (TH) levels, dopamine (DA) levels, 3,4-dihydroxyphenylacetic acid (DOPAC) levels and cell death markers in the nervous system. Adults exposed to MnCl2 for 4days (0.5, 1.0 and 1...
November 17, 2016: Aquatic Toxicology
https://www.readbyqxmd.com/read/27897674/dopamine-alters-the-fidelity-of-working-memory-representations-according-to-attentional-demands
#3
Sean James Fallon, Nahid Zokaei, Agnes Norbury, Sanjay G Manohar, Masud Husain
Capacity limitations in working memory (WM) necessitate the need to effectively control its contents. Here, we examined the effect of cabergoline, a dopamine D2 receptor agonist, on WM using a continuous report paradigm that allowed us to assess the fidelity with which items are stored. We assessed recall performance under three different gating conditions: remembering only one item, being cued to remember one target among distractors, and having to remember all items. Cabergoline had differential effects on recall performance according to whether distractors had to be ignored and whether mnemonic resources could be deployed exclusively to the target...
November 29, 2016: Journal of Cognitive Neuroscience
https://www.readbyqxmd.com/read/27884068/silver-nanoparticle-exposure-in-pregnant-rats-increases-gene-expression-of-tyrosine-hydroxylase-and-monoamine-oxidase-in-offspring-brain
#4
Seyed Reza Fatemi Tabatabaie, Babak Mehdiabadi, Najmeh Mori Bakhtiari, Mohammad Reza Tabandeh
CONTEXT: Maternal exposure to silver nanoparticles (AgNPs) affects neurobehavioral reflexes and spatial memory formation in offspring. Although the transmission of AgNPs into the brain has been reported, its toxic effect on dopamine metabolism in the brain of offspring has not been studied so far. OBJECTIVE: The aim of the present study was to investigate the expression levels of tyrosine hydroxylase (TH) and monoamine oxidase A (MAO-A) genes in the brain of offspring exposed in utero to various concentrations of AgNPs...
November 24, 2016: Drug and Chemical Toxicology
https://www.readbyqxmd.com/read/27872762/understanding-the-functional-plasticity-in-neural-networks-of-the-basal-ganglia-in-cocaine-use-disorder-a-role-for-allosteric-receptor-receptor-interactions-in-a2a-d2-heteroreceptor-complexes
#5
REVIEW
Dasiel O Borroto-Escuela, Karolina Wydra, Julia Pintsuk, Manuel Narvaez, Fidel Corrales, Magdalena Zaniewska, Luigi F Agnati, Rafael Franco, Sergio Tanganelli, Luca Ferraro, Malgorzata Filip, Kjell Fuxe
Our hypothesis is that allosteric receptor-receptor interactions in homo- and heteroreceptor complexes may form the molecular basis of learning and memory. This principle is illustrated by showing how cocaine abuse can alter the adenosine A2AR-dopamine D2R heterocomplexes and their receptor-receptor interactions and hereby induce neural plasticity in the basal ganglia. Studies with A2AR ligands using cocaine self-administration procedures indicate that antagonistic allosteric A2AR-D2R heterocomplexes of the ventral striatopallidal GABA antireward pathway play a significant role in reducing cocaine induced reward, motivation, and cocaine seeking...
2016: Neural Plasticity
https://www.readbyqxmd.com/read/27872341/amygdala-circuits-for-fear-memory-a-key-role-for-dopamine-regulation
#6
REVIEW
Joo Han Lee, Seungho Lee, Joung-Hun Kim
In addition to modulating a number of cognitive functions including reward, punishment, motivation, and salience, dopamine (DA) plays a pivotal role in regulating threat-related emotional memory. Changes in neural circuits of the amygdala nuclei are also critically involved in the acquisition and expression of emotional memory. In this review, we summarize the regulation of amygdala circuits by DA. Specifically, we describe DA signaling in the amygdala, and DA regulation of synaptic transmission and synaptic plasticity of the amygdala neurons...
November 20, 2016: Neuroscientist: a Review Journal Bringing Neurobiology, Neurology and Psychiatry
https://www.readbyqxmd.com/read/27868798/neurochemical-and-behavioral-effects-of-nigella-sativa-and-olea-europaea-oil-in-rats
#7
M Atif Raza Cheema, Shazia Nawaz, Sumera Gul, Tabinda Salman, Sabira Naqvi, Ahsana Dar, Darakhshan J Haleem
OBJECTIVES: In the last few decades, therapeutic uses of medicinal compounds present in food as a normal constituent has risen substantially, largely because of their fewer side effects and adequate efficacy. This study is designed to investigate a role of brain serotonin (5-HT) and dopamine (DA) in the potential nootropic, anxiolytic, and other beneficial effects of Nigella sativa (NS) and Olea europaea (OE) oil in rat models. METHODS: Animals were treated with NS and OE oil orally at doses of 0...
November 21, 2016: Nutritional Neuroscience
https://www.readbyqxmd.com/read/27865867/d1-like-dopamine-receptor-dysfunction-in-the-lateral-habenula-nucleus-increased-anxiety-like-behavior-in-rat
#8
Jiangping Chan, Yiling Ni, Pengyue Zhang, Yanmei Chen, Jichuan Zhang
Lateral habenula (LHb) is important for emotional processing. It is a link node between forebrain and midbrain. LHb is reciprocally connected with ventral tegmental area, acting as a regulatory center for the dopaminergic system. However, the role of dopamine receptors in the LHb in emotional processing is less clear. In the present study, the expression of dopamine D1 and D2 receptors in LHb was testified by western blot. In addition, D1- or D2-like receptor agonist or antagonist was bilaterally administered into the LHb, anxiety-like and depressive-like behaviors were tested 15min later in rats...
November 16, 2016: Neuroscience
https://www.readbyqxmd.com/read/27856221/levodopa-improves-learning-and-memory-ability-on-global-cerebral-ischemia-reperfusion-injured-rates-in-the-morris-water-maze-test
#9
Wenzhu Wang, Lixu Liu, Peng Jiang, Chen Chen, Tong Zhang
Previous studies have shown that levodopa (L-dopa) for 1-7days improved the consciousness level of certain patients who suffered from ischemia-reperfusion injury and were comatose for a long time period after cerebral resuscitation treatment. It also has an awakening effect on patients with disorders of consciousness. This study aimed to investigate whether L-dopa, which is used clinically to treat Parkinson's disease, might also ameliorate the behavior of rats following global cerebral ischemia-reperfusion injury...
November 14, 2016: Neuroscience Letters
https://www.readbyqxmd.com/read/27847474/reward-anticipation-dynamics-during-cognitive-control-and-episodic-encoding-implications-for-dopamine
#10
Kimberly S Chiew, Jessica K Stanek, R Alison Adcock
Dopamine (DA) modulatory activity critically supports motivated behavior. This modulation operates at multiple timescales, but the functional roles of these distinct dynamics on cognition are still being characterized. Reward processing has been robustly linked to DA activity; thus, examining behavioral effects of reward anticipation at different timing intervals, corresponding to different putative dopaminergic dynamics, may help in characterizing the functional role of these dynamics. Towards this end, we present two research studies investigating reward motivation effects on cognitive control and episodic memory, converging in their manipulation of rapid vs...
2016: Frontiers in Human Neuroscience
https://www.readbyqxmd.com/read/27817108/effects-of-neonatal-methamphetamine-and-stress-on-brain-monoamines-and-corticosterone-in-preweanling-rats
#11
Sarah A Jablonski, Devon L Graham, Charles V Vorhees, Michael T Williams
Neonatal exposure to methamphetamine (MA) and developmental chronic stress significantly alter neurodevelopmental profiles that show a variety of long-term physiological and behavioral effects. In the current experiment, Sprague-Dawley rats were exposed to one of two housing conditions along with MA. Rats were given 0 (saline), 5, or 7.5 mg/kg MA, four times per day from postnatal day (P)11 to 15 or P11 to 20. Half of the litters were reared in cages with standard bedding and half with no bedding. Separate litters were assessed at P15 or P20 for organ weights (adrenals, spleen, thymus); corticosterone; and monoamine assessments (dopamine, serotonin, norepinephrine) and their metabolites within the neostriatum, hippocampus, and prefrontal cortex...
November 5, 2016: Neurotoxicity Research
https://www.readbyqxmd.com/read/27807366/cell-type-specific-modulation-of-targets-and-distractors-by-dopamine-d1-receptors-in-primate-prefrontal-cortex
#12
Simon N Jacob, Maximilian Stalter, Andreas Nieder
The prefrontal cortex (PFC) is crucial for maintaining relevant information in working memory and resisting interference. PFC neurons are strongly regulated by dopamine, but it is unknown whether dopamine receptors are involved in protecting target memories from distracting stimuli. We investigated the prefrontal circuit dynamics and dopaminergic modulation of targets and distractors in monkeys trained to ignore interfering stimuli in a delayed-match-to-numerosity task. We found that dopamine D1 receptors (D1Rs) modulate the recovery of task-relevant information following a distracting stimulus...
October 27, 2016: Nature Communications
https://www.readbyqxmd.com/read/27802831/persisting-neurobehavioral-effects-of-developmental-copper-exposure-in-wildtype-and-metallothionein-1-and-2-knockout-mice
#13
Ann Petro, Hannah G Sexton, Caroline Miranda, Anit Rastogi, Jonathan H Freedman, Edward D Levin
BACKGROUND: Metallothioneins (MT) are small proteins, which are crucial for the distribution of heavy and transition metals. Previously, we found in mice that knockout of MT 1 and 2 genes (MTKO) impaired spatial learning and potentiated the learning impairment caused by developmental mercury exposure. The current study examined the neurocognitive and neurochemical effects of MTKO with the developmental copper (Cu) supplementation. METHODS: Wildtype (WT) and MTKO mice were given supplemental Cu (0, 10 or 50 mg/l) in their drinking water during gestation and until weaning...
November 2, 2016: BMC Pharmacology & Toxicology
https://www.readbyqxmd.com/read/27799909/neuromodulation-of-the-feedforward-dentate-gyrus-ca3-microcircuit
#14
REVIEW
Luke Y Prince, Travis J Bacon, Cezar M Tigaret, Jack R Mellor
The feedforward dentate gyrus-CA3 microcircuit in the hippocampus is thought to activate ensembles of CA3 pyramidal cells and interneurons to encode and retrieve episodic memories. The creation of these CA3 ensembles depends on neuromodulatory input and synaptic plasticity within this microcircuit. Here we review the mechanisms by which the neuromodulators aceylcholine, noradrenaline, dopamine, and serotonin reconfigure this microcircuit and thereby infer the net effect of these modulators on the processes of episodic memory encoding and retrieval...
2016: Frontiers in Synaptic Neuroscience
https://www.readbyqxmd.com/read/27799080/the-role-of-orgasm-in-the-development-and-shaping-of-partner-preferences
#15
Genaro A Coria-Avila, Deissy Herrera-Covarrubias, Nafissa Ismail, James G Pfaus
BACKGROUND: The effect of orgasm on the development and shaping of partner preferences may involve a catalysis of the neurochemical mechanisms of bonding. Therefore, understanding such process is relevant for neuroscience and psychology. METHODS: A systematic review was carried out using the terms Orgasm, Sexual Reward, Partner Preference, Pair Bonding, Brain, Learning, Sex, Copulation. RESULTS: In humans, concentrations of arousing neurotransmitters and potential bonding neurotransmitters increase during orgasm in the cerebrospinal fluid and the bloodstream...
2016: Socioaffective Neuroscience & Psychology
https://www.readbyqxmd.com/read/27793591/association-between-comt-genotype-and-the-control-of-memory-guided-saccades-individual-differences-in-healthy-adults-reveal-a-detrimental-role-of-dopamine
#16
Jutta Billino, Jürgen Hennig, Karl R Gegenfurtner
The neural circuits involved in oculomotor control are well described; however, neuromodulation of eye movements is still hardly understood. Memory guided saccades have been extensively studied and in particular neurophysiological evidence from monkey studies points to a crucial functional role of prefrontal dopamine activity. We exploited individual differences in dopamine regulation due to the well established COMT (catechol-O-methyltransferase) Val(158)Met polymorphism to explore the link between prefrontal dopamine activity and memory guided saccades in healthy subjects...
October 25, 2016: Vision Research
https://www.readbyqxmd.com/read/27790098/adolescent-maturational-transitions-in-the-prefrontal-cortex-and-dopamine-signaling-as-a-risk-factor-for-the-development-of-obesity-and-high-fat-high-sugar-diet-induced-cognitive-deficits
#17
REVIEW
Amy C Reichelt
Adolescence poses as both a transitional period in neurodevelopment and lifestyle practices. In particular, the developmental trajectory of the prefrontal cortex (PFC), a critical region for behavioral control and self-regulation, is enduring, not reaching functional maturity until the early 20 s in humans. Furthermore, the neurotransmitter dopamine is particularly abundant during adolescence, tuning the brain to rapidly learn about rewards and regulating aspects of neuroplasticity. Thus, adolescence is proposed to represent a period of vulnerability towards reward-driven behaviors such as the consumption of palatable high fat and high sugar diets...
2016: Frontiers in Behavioral Neuroscience
https://www.readbyqxmd.com/read/27789382/effects-of-sesamin-on-motor-and-memory-deficits-in-an-mptp-lesioned-mouse-model-of-parkinson-s-disease-treated-with-l-dopa
#18
T T Zhao, K S Shin, K S Kim, H J Park, H J Kim, K E Lee, M K Lee
The present study investigated the effects of (-)-sesamin on motor and memory deficits in a 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-lesioned mouse model of Parkinson's disease (PD) with l-3,4-dihydroxyphenylalanine (l-DOPA). MPTP-lesioned (30mg/kg/day, 5days) mice showed deficits in memory including habit learning memory and spatial memory, which were further aggravated by daily treatment with 25mg/kg l-DOPA for 21days. However, daily treatment with (-)-sesamin (25 and 50mg/kg) for 21days ameliorated memory deficits in an MPTP-lesioned mouse model of PD treated with l-DOPA (25mg/kg)...
December 17, 2016: Neuroscience
https://www.readbyqxmd.com/read/27779907/the-neurocognitive-cost-of-enhancing-cognition-with-methylphenidate-improved-distractor-resistance-but-impaired-updating
#19
Sean James Fallon, Marieke E van der Schaaf, Niels Ter Huurne, Roshan Cools
A balance has to be struck between supporting distractor-resistant representations in working memory and allowing those representations to be updated. Catecholamine, particularly dopamine, transmission has been proposed to modulate the balance between the stability and flexibility of working memory representations. However, it is unclear whether drugs that increase catecholamine transmission, such as methylphenidate, optimize this balance in a task-dependent manner or bias the system toward stability at the expense of flexibility (or vice versa)...
October 25, 2016: Journal of Cognitive Neuroscience
https://www.readbyqxmd.com/read/27776953/association-between-dbh-19bp-insertion-deletion-polymorphism-and-cognition-in-schizophrenia-with-and-without-tardive-dyskinesia
#20
Li Hui, Mei Han, Guang Zhong Yin, Yingyang Zhang, Xu Feng Huang, Zheng Kang Qian, Wei Guo Gu, Xiao Chu Gu, Xiao Min Zhu, Jair C Soares, Yuping Ning, Yingjun Zheng, Xiang Dong Du, Xiang Yang Zhang
Long-term antipsychotic treatment for schizophrenia is associated with the development of tardive dyskinesia (TD), which is involved in increased cognitive impairment. Dopamine beta-hydroxylase (DBH) gene associated with dopamine and norepinephrine systems influences cognition. Schizophrenia with TD have higher DBH activity than those without TD. This study examined whether DBH5'-insertion/deletion (-Ins/Del) polymorphism could influence cognitive function in schizophrenia with and without TD. The presence of DBH5'-Ins/Del polymorphism was determined in 345 schizophrenia with TD and 397 schizophrenia without TD...
October 21, 2016: Schizophrenia Research
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