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Dopamine and memory

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https://www.readbyqxmd.com/read/29439241/near-infrared-deep-brain-stimulation-via-upconversion-nanoparticle-mediated-optogenetics
#1
Shuo Chen, Adam Z Weitemier, Xiao Zeng, Linmeng He, Xiyu Wang, Yanqiu Tao, Arthur J Y Huang, Yuki Hashimotodani, Masanobu Kano, Hirohide Iwasaki, Laxmi Kumar Parajuli, Shigeo Okabe, Daniel B Loong Teh, Angelo H All, Iku Tsutsui-Kimura, Kenji F Tanaka, Xiaogang Liu, Thomas J McHugh
Optogenetics has revolutionized the experimental interrogation of neural circuits and holds promise for the treatment of neurological disorders. It is limited, however, because visible light cannot penetrate deep inside brain tissue. Upconversion nanoparticles (UCNPs) absorb tissue-penetrating near-infrared (NIR) light and emit wavelength-specific visible light. Here, we demonstrate that molecularly tailored UCNPs can serve as optogenetic actuators of transcranial NIR light to stimulate deep brain neurons. Transcranial NIR UCNP-mediated optogenetics evoked dopamine release from genetically tagged neurons in the ventral tegmental area, induced brain oscillations through activation of inhibitory neurons in the medial septum, silenced seizure by inhibition of hippocampal excitatory cells, and triggered memory recall...
February 9, 2018: Science
https://www.readbyqxmd.com/read/29433615/a-haplotype-of-the-dopamine-transporter-gene-modulates-regional-homogeneity-gray-matter-volume-and-visual-memory-in-children-with-attention-deficit-hyperactivity-disorder
#2
C Y Shang, H Y Lin, W Y Tseng, S S Gau
BACKGROUND: The dopamine transporter gene (DAT1) and visual memory deficits have been consistently reported to be associated with attention-deficit/hyperactivity disorder (ADHD). This study aimed to examine whether a DAT1 haplotype affected functional and structural brain alterations in children with ADHD and whether those alterations were associated with visual memory. METHOD: We recruited a total of 37 drug-naïve children with ADHD (17 with the DAT1 rs27048 (C)/rs429699 (T) haplotype and 20 without the CT haplotype) and 37 typically developing children (17 with the CT haplotype and 20 without the CT haplotype)...
February 13, 2018: Psychological Medicine
https://www.readbyqxmd.com/read/29428214/the-effects-of-bilateral-continuous-and-chronic-deep-brain-stimulation-of-the-medial-forebrain-bundle-in-a-rodent-model-of-depression
#3
Stephanie Thiele, Luciano Furlanetti, Lisa-Marie Pfeiffer, Volker A Coenen, Máté D Döbrössy
BACKGROUND: Clinical trials of supra-lateral medial forebrain bundle (MFB) Deep Brain Stimulation (DBS) in treatment resistant major depressive patients have shown rapid and long-term benefits. OBJECTIVE/HYPOTHESIS: The study used Flinders Sensitive Line (FSL) rats with previously identified depressive-like phenotype to assess the range of behavior modification achieved by MFB DBS. METHODS: Male FSL and wild-type Sprague-Dawley rats as Controls were tested on mood/anxiety/exploration, cognitive and motor behaviors...
February 8, 2018: Experimental Neurology
https://www.readbyqxmd.com/read/29427284/a-single-high-dose-of-methamphetamine-reduces-monoamines-and-impairs-egocentric-and-allocentric-learning-and-memory-in-adult-male-rats
#4
Arnold Gutierrez, Michael T Williams, Charles V Vorhees
Methamphetamine (MA) alters dopamine markers and cognitive function in heavy users. In rodents, there are MA dosing regimens that induce concordant effects using repeated administration at spaced intervals. These regimens are effective but complicate experiments designed to disentangle the effects of the drug on different brain regions in relation to their cognitive effects because of treatment spacing. In an effort to simplify the model, we tested whether a single dose of MA could induce the same monoamine and cognitive effects as multiple, spaced dosing without affecting survival...
February 9, 2018: Neurotoxicity Research
https://www.readbyqxmd.com/read/29425773/cocaine-and-amphetamine-regulated-transcript-peptide-cart-alleviates-mk-801-induced-schizophrenic-dementia-like-symptoms
#5
Chandrashekhar D Borkar, Ashish P Bharne, B Nagalakshmi, Amul J Sakharkar, Nishikant K Subhedar, Dadasaheb M Kokare
Exaggerated thoughts, diminished mood and impaired cognition are the hallmarks of the schizophrenia-like condition. These symptoms are attributed to the dysregulation of dopamine and glutamate signaling in the brain. Since cocaine- and amphetamine-regulated transcript peptide (CART) modulates actions of dopamine as well as glutamate, we tested the role of this peptide in MK-801 induced schizophrenic dementia-like condition. MK-801 treated rats were allowed to interact with conspecific juvenile and tested for short-term (30-min) and long-term (24-hr) social memory acquisition and recall...
February 6, 2018: Neuroscience
https://www.readbyqxmd.com/read/29423319/improvement-of-long-term-memory-access-with-a-pro-dopamine-regulator-in-an-elderly-male-are-we-targeting-dopamine-tone
#6
Thomas McLaughlin, David Han, James Nicholson, Bruce Steinberg, Kenneth Blum, Marcelo Febo, Eric Braverman, Mona Li, Lyle Fried, Rajendra Badgaiyan
With aging, there is decline in both short-term and long-term memory. This effect is magnified by epigenetic insults on specific, dopamine- related genes (e.g., DRD2, DAT1) as well as by impaired or reduced mRNA transcription. In addition, long-term memory ability is positively correlated with dopamine function and there is evidence that aging is associated with a reduction in brain dopamine D2 receptors, with an acceleration seen in aging-induced dementia. As a result, the authors tested the acute effect of a Pro-Dopamine Regulator (KB220Z, liquid Nano variant) on an aspect of long-term memory performance in a 77-year-old, highly functional male, using the Animal Naming Test (ANT)...
May 2017: Journal of Systems and Integrative Neuroscience
https://www.readbyqxmd.com/read/29415163/genetic-variation-of-a-drd2-co-expression-network-is-associated-with-changes-in-prefrontal-function-after-d2-receptors-stimulation
#7
Pierluigi Selvaggi, Giulio Pergola, Barbara Gelao, Pasquale Di Carlo, Maria Antonietta Nettis, Graziella Amico, Leonardo Fazio, Antonio Rampino, Fabio Sambataro, Giuseppe Blasi, Alessandro Bertolino
Dopamine D2 receptors (D2Rs) contribute to the inverted U-shaped relationship between dopamine signaling and prefrontal function. Genetic networks from post-mortem human brain revealed 84 partner genes co-expressed with DRD2. Moreover, eight functional single nucleotide polymorphisms combined into a polygenic co-expression index (PCI) predicted co-expression of this DRD2 network and were associated with prefrontal function in humans. Here, we investigated the non-linear association of the PCI with behavioral and Working Memory (WM) related brain response to pharmacological D2Rs stimulation...
February 3, 2018: Cerebral Cortex
https://www.readbyqxmd.com/read/29410219/dopaminergic-modulation-of-hemodynamic-signal-variability-and-the-functional-connectome-during-cognitive-performance
#8
Mohsen Alavash, Sung-Joo Lim, Christiane Thiel, Bernhard Sehm, Lorenz Deserno, Jonas Obleser
Dopamine underlies important aspects of cognition, and has been suggested to boost cognitive performance. However, how dopamine modulates the large-scale cortical dynamics during cognitive performance has remained elusive. Using functional MRI during a working memory task in healthy young human listeners, we investigated the effect of levodopa (l-dopa) on two aspects of cortical dynamics, blood oxygen-level-dependent (BOLD) signal variability and the functional connectome of large-scale cortical networks. We here show that enhanced dopaminergic signaling modulates the two potentially interrelated aspects of large-scale cortical dynamics during cognitive performance, and the degree of these modulations is able to explain inter-individual differences in l-dopa-induced behavioral benefits...
February 2, 2018: NeuroImage
https://www.readbyqxmd.com/read/29410048/a-daily-single-dose-of-a-novel-modafinil-analogue-ce-123-improves-memory-acquisition-and-memory-retrieval
#9
Martina Kristofova, Yogesh D Aher, Marija Ilic, Bojana Radoman, Predrag Kalaba, Vladimir Dragacevic, Nilima Y Aher, Johann Leban, Volker Korz, Lisa Zanon, Winfried Neuhaus, Marcus Wieder, Thierry Langer, Ernst Urban, Harald H Sitte, Harald Hoeger, Gert Lubec, Jana Aradska
Dopamine reuptake inhibitors have been shown to improve cognitive parameters in various tasks and animal models. We recently reported a series of modafinil analogues, of which the most promising, 5-((benzhydrylsulfinyl)methyl) thiazole (CE-123), was selected for further development. The present study aims to characterize pharmacological properties of CE-123 and to investigate the potential to enhance memory performance in a rat model. In vitro transporter assays were performed in cells expressing human transporters...
February 1, 2018: Behavioural Brain Research
https://www.readbyqxmd.com/read/29408274/running-exercise-mitigates-the-negative-consequences-of-chronic-stress-on-dorsal-hippocampal-long-term-potentiation-in-male-mice
#10
Roxanne M Miller, David Marriott, Jacob Trotter, Tyler Hammond, Dane Lyman, Timothy Call, Bethany Walker, Nathanael Christensen, Deson Haynie, Zoie Badura, Morgan Homan, Jeffrey G Edwards
In the hippocampus, learning and memory are likely mediated by synaptic plasticity, known as long-term potentiation (LTP). While chronic intermittent stress is negatively correlated, and exercise positively correlated to LTP induction, we examined whether exercise could mitigate the negative consequences of stress on LTP when co-occurring with stress. Mice were divided into four groups: sedentary no stress, exercise no stress, exercise with stress, and sedentary with stress. Field electrophysiology performed on brain slices confirmed that stress alone significantly reduced dorsal CA1 hippocampal LTP and exercise alone increased LTP compared to controls...
February 9, 2018: Neurobiology of Learning and Memory
https://www.readbyqxmd.com/read/29408055/methylphenidate-induces-state-dependency-of-social-recognition-learning-central-components
#11
Carolina Garrido Zinn, Leticia Bühler, Lorena Evelyn Cavalcante, Scheila Daiane Schmidt, Flávia Fagundes Ferreira, Mara Lise Zanini, Cristiane Regina Guerino Furini, Jociane de Carvalho Myskiw, Ivan Izquierdo
Methylphenidate (MPH) is a widely prescribed drug for the treatment of attention-deficit hyperactivity disorder. Findings in the literature suggest that the effects of MPH on memory may result from increased extracellular levels of norepinephrine (NE) and dopamine (DA). Here, we report that the systemic administration of MPH before the acquisition phase in a social discrimination task impaired the retrieval of the social recognition memory (SRM), but made it state-dependent: another administration of MPH before the retention test recovered the SRM...
February 3, 2018: Neurobiology of Learning and Memory
https://www.readbyqxmd.com/read/29407766/dopamine-d3-receptor-blockade-rescues-hyper-dopamine-activity-induced-deficit-in-novel-object-recognition-memory
#12
Pi-Kai Chang, Lung Yu, Jin-Chung Chen
Patients afflicted with bipolar disorder demonstrate significant impairments in recognition and episodic memory during acute depressive and manic episodes. These impairments and the related pathophysiology may result from over-activation of the brain dopamine (DA) system. In order to model overactive DA transmission in a well-established novel object recognition (NOR) memory test, we used DA transporter knockdown (DAT-KD) mice, which exhibit reduced DAT expression and display hyper-dopaminergic phenotypes. DAT-KD mice exhibited impaired NOR memory compared to wild-type (WT) mice...
February 1, 2018: Neuropharmacology
https://www.readbyqxmd.com/read/29405517/activation-of-amylin-receptors-attenuates-alcohol-mediated-behaviours-in-rodents
#13
Aimilia Lydia Kalafateli, Daniel Vallöf, Elisabet Jerlhag
Alcohol expresses its reinforcing properties by activating areas of the mesolimbic dopamine system, which consists of dopaminergic neurons projecting from the ventral tegmental area to the nucleus accumbens. The findings that reward induced by food and addictive drugs involve common mechanisms raise the possibility that gut-brain hormones, which control appetite, such as amylin, could be involved in reward regulation. Amylin decreases food intake, and despite its implication in the regulation of natural rewards, tenuous evidence support amylinergic mediation of artificial rewards, such as alcohol...
February 6, 2018: Addiction Biology
https://www.readbyqxmd.com/read/29404643/baicalin-reverses-the-impairment-of-synaptogenesis-induced-by-dopamine-burden-via-the-stimulation-of-gabaar-trkb-interaction-in-minimal-hepatic-encephalopathy
#14
Saidan Ding, Weishan Zhuge, Jiangnan Hu, Jianjing Yang, Xuebao Wang, Fangfang Wen, Chengde Wang, Qichuan Zhuge
BACKGROUND: It has been reported that D1 receptor (D1R) activation reduces GABAA receptor (GABAAR) current, and baicalin (BAI) displays therapeutic efficacy in diseases involving cognitive impairment. METHODS: We investigated the mechanisms by which BAI could improve DA-induced minimal hepatic encephalopathy (MHE) using immunoblotting, immunofluorescence, and co-immunoprecipitation. RESULTS: BAI did not induce toxicity on the primary cultured neurons...
February 6, 2018: Psychopharmacology
https://www.readbyqxmd.com/read/29391391/a-systematic-review-of-the-role-of-the-nociceptin-receptor-system-in-stress-cognition-and-reward-relevance-to-schizophrenia
#15
REVIEW
Muhammad Saad Khan, Isabelle Boileau, Nathan Kolla, Romina Mizrahi
Schizophrenia is a debilitating neuropsychiatric illness that is characterized by positive, negative, and cognitive symptoms. Research over the past two decades suggests that the nociceptin receptor system may be involved in domains affected in schizophrenia, based on evidence aligning it with hallmark features of the disorder. First, aberrant glutamatergic and striatal dopaminergic function are associated with psychotic symptoms, and the nociceptin receptor system has been shown to regulate dopamine and glutamate transmission...
February 2, 2018: Translational Psychiatry
https://www.readbyqxmd.com/read/29379379/cardamom-elettaria-cardamomum-perinatal-exposure-effects-on-the-development-behavior-and-biochemical-parameters-in-mice-offspring
#16
Gasem Mohammad Abu-Taweel
Cardamom is a strong antioxidant plant, so it is called the queen of spices. In the present study, we explored the potentials of cardamom on developmental, learning ability and biochemical parameters of mice offspring. Thirty pregnant mice were allocated to three groups of ten animals in each. Groups Π and Ш received pilsbury's Diet containing 10 and 20% of cardamom (w/w) respectively, whereas Group I used as control. Cardomom was administered from the first day of pregnancy and was continued until post-natal day 15 (PD 15) and thereafter the mothers were switched to plain pilsbury's Diet...
January 2018: Saudi Journal of Biological Sciences
https://www.readbyqxmd.com/read/29377353/blockade-of-dopamine-d2-receptors-disrupts-intrahippocampal-connectivity-and-enhances-pain-related-working-memory-deficits-in-neuropathic-pain-rats
#17
H Cardoso-Cruz, M Dourado, C Monteiro, V Galhardo
BACKGROUND: Dopamine (DA) is thought to be important to local hippocampal networks integrity during spatial working memory (sWM) processing. Chronic pain may contribute to deficient dopaminergic signalling, which may in turn affect cognition. However, the neural mechanisms that determine this impairment are poorly understood. Here, we evaluated whether the sWM impairment characteristic of animal models of chronic pain is dependent on DA D2 receptor (D2r) activity. METHODS: To address this issue, we implanted multichannel arrays of electrodes in the dorsal and ventral hippocampal CA1 field (dvCA1) of rats and recorded the neuronal activity during a classical delayed food-reinforced T-maze sWM task...
January 26, 2018: European Journal of Pain: EJP
https://www.readbyqxmd.com/read/29361577/nosema-ceranae-parasitism-impacts-olfactory-learning-and-memory-and-neurochemistry-in-honey-bees-apis-mellifera
#18
Stephanie L Gage, Catherine Kramer, Samantha Calle, Mark Carroll, Michael Heien, Gloria DeGrandi-Hoffman
Nosema sp. is an internal parasite of the honey bee, Apis mellifera, and one of the leading contributors to colony losses worldwide. This parasite is found in the honey bee midgut, and has profound consequences on the host's physiology. Nosema sp. impairs foraging performance in honey bees, yet, it is unclear whether this parasite affects the bee's neurobiology. In this study, we examine whether Nosema sp. affects odor learning and memory and whether the brains of parasitized bees show differences in amino acids and biogenic amines...
December 19, 2017: Journal of Experimental Biology
https://www.readbyqxmd.com/read/29348190/pronounced-hyperactivity-cognitive-dysfunctions-and-bdnf-dysregulation-in-dopamine-transporter-knockout-rats
#19
Damiana Leo, Ilya Sukhanov, Francesca Zoratto, Placido Illiano, Lucia Caffino, Fabrizio Sanna, Giulia Messa, Marco Emanuele, Alessandro Esposito, Maria Dorofeikova, Evgeny A Budygin, Liudmila Mus, Evgenia E Efimova, Marco Niello, Stefano Espinoza, Tatyana D Sotnikova, Marius C Hoener, Gianni Laviola, Fabio Fumagalli, Walter Adriani, Raul R Gainetdinov
Dopamine (DA) controls many vital physiological functions and is critically involved in several neuropsychiatric disorders such as schizophrenia and attention deficit hyperactivity disorder (ADHD). The major function of the plasma membrane dopamine transporter (DAT) is the rapid uptake of released DA into presynaptic nerve terminals leading to control of both the extracellular levels of DA and the intracellular stores of DA. Here, we present a newly developed strain of rats (DAT-knockout, DAT-KO rats) in which the gene encoding the DAT has been disrupted by using zinc finger nuclease technology (ZFN)...
January 18, 2018: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/29331265/mechanisms-of-memory-disruption-in-depression
#20
REVIEW
Daniel G Dillon, Diego A Pizzagalli
Depressed individuals typically show poor memory for positive events, potentiated memory for negative events, and impaired recollection. These phenomena are clinically important but poorly understood. Compelling links between stress and depression suggest promising candidate mechanisms. Stress can suppress hippocampal neurogenesis, inhibit dopamine neurons, and sensitize the amygdala. We argue that these phenomena may impair pattern separation, disrupt the encoding of positive experiences, and bias retrieval toward negative events, respectively, thus recapitulating core aspects of memory disruption in depression...
January 10, 2018: Trends in Neurosciences
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