keyword
MENU ▼
Read by QxMD icon Read
search

Dopamine and memory

keyword
https://www.readbyqxmd.com/read/28326037/differences-on-brain-connectivity-in-adulthood-are-present-in-subjects-with-iron-deficiency-anemia-in-infancy
#1
Cecilia Algarin, Keerthana Deepti Karunakaran, Sussanne Reyes, Cristian Morales, Betsy Lozoff, Patricio Peirano, Bharat Biswal
Iron deficiency continues to be the most prevalent micronutrient deficit worldwide. Since iron is involved in several processes including myelination, dopamine neurotransmission and neuronal metabolism, the presence of iron deficiency anemia (IDA) in infancy relates to long-lasting neurofunctional effects. There is scarce data regarding whether these effects would extend to former iron deficient anemic human adults. Resting state functional magnetic resonance imaging (fMRI) is a novel technique to explore patterns of functional connectivity...
2017: Frontiers in Aging Neuroscience
https://www.readbyqxmd.com/read/28314129/crack-cocaine-inhalation-induces-schizophrenia-like-symptoms-and-molecular-alterations-in-mice-prefrontal-cortex
#2
Lorena Bianchine Areal, Alice Laschuk Herlinger, Fabrício Souza Pelição, Cristina Martins-Silva, Rita Gomes Wanderley Pires
Crack cocaine (crack) addiction represents a major social and health burden, especially seeing as users are more prone to engage in criminal and violent acts. Crack users show a higher prevalence of psychiatric comorbidities - particularly antisocial personality disorders - when compared to powder cocaine users. They also develop cognitive deficits related mainly to executive functions, including working memory. It is noteworthy that stimulant drugs can induce psychotic states, which appear to mimic some symptoms of schizophrenia among users...
March 6, 2017: Journal of Psychiatric Research
https://www.readbyqxmd.com/read/28294132/5-ht2c-agonists-modulate-schizophrenia-like-behaviors-in-mice
#3
Vladimir M Pogorelov, Ramona M Rodriguiz, Jianjun Cheng, Mei Huang, Claire M Schmerberg, Herbert Y Meltzer, Bryan L Roth, Alan P Kozikowski, William C Wetsel
All FDA-approved antipsychotic drugs (APDs) target primarily dopamine D2 or serotonin (5-HT2A) receptors, or both; however, these medications are not universally effective, they may produce undesirable side-effects, and provide only partial amelioration of negative and cognitive symptoms. The heterogeneity of pharmacological responses in schizophrenic patients suggests additional drug-targets may be effective in improving aspects of this syndrome. Recent evidence suggests that 5-HT2C receptors may be a promising target for schizophrenia since their activation reduces mesolimbic nigrostriatal dopamine release (which conveys antipsychotic action), they are expressed almost exclusively in CNS, and have weight-loss promoting capabilities...
March 15, 2017: Neuropsychopharmacology: Official Publication of the American College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/28293263/saikosaponin-a-alleviates-symptoms-of-attention-deficit-hyperactivity-disorder-through-downregulation-of-dat-and-enhancing-bdnf-expression-in-spontaneous-hypertensive-rats
#4
Sun Jichao, Han Xinmin, Ren Xianguo, Yin Dongqi, Zhou Rongyi, Lei Shuang, You Yue, Song Yuchen, Ying Jingnan
The disturbed dopamine availability and brain-derived neurotrophic factor (BDNF) expression are due in part to be associated with attention deficit hyperactivity disorder (ADHD). In this study, we investigated the therapeutical effect of saikosaponin a (SSa) isolated from Bupleurum Chinese DC, against spontaneously hypertensive rat (SHR) model of ADHD. Methylphenidate and SSa were orally administered for 3 weeks. Activity was assessed by open-field test and Morris water maze test. Dopamine (DA) and BDNF were determined in specific brain regions...
2017: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/28291572/noradrenaline-transporter-blockade-increases-fronto-parietal-functional-connectivity-relevant-for-working-memory
#5
Dennis Hernaus, Marta Ma Casales Santa, Jan Stefan Offermann, Thérèse Van Amelsvoort
Experimental animal work has demonstrated that dopamine and noradrenaline play an essential role in modulating prefrontal cortex-mediated networks underlying working memory performance. Studies of functional connectivity have been instrumental in extending such notions to humans but, so far, have almost exclusively focussed on pharmacological agents with a predominant dopaminergic mechanism of action. Here, we investigate the effect of a single dose of atomoxetine 60mg, a noradrenaline transporter inhibitor, on working memory performance and associated functional connectivity during an n-back task in 19 healthy male volunteers...
March 10, 2017: European Neuropsychopharmacology: the Journal of the European College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/28290500/pramipexole-restores-depressed-transmission-in-the-ventral-hippocampus-following-mptp-lesion
#6
Javier Castro-Hernández, Paul A Adlard, David I Finkelstein
The hippocampus has a significant association with memory, cognition and emotions. The dopaminergic projections from both the ventral tegmental area and substantia nigra are thought to be involved in hippocampal activity. To date, however, few studies have investigated dopaminergic innervation in the hippocampus or the functional consequences of reduced dopamine in disease models. Further complicating this, the hippocampus exhibits anatomical and functional differentiation along its dorso-ventral axis. In this work we investigated the role of dopamine on hippocampal long term potentiation using D-amphetamine, which stimulates dopamine release, and also examined how a dopaminergic lesion affects the synaptic transmission across the anatomic subdivisions of the hippocampus...
March 14, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28289600/conflict-processing-in-juvenile-patients-with-neurofibromatosis-type-1-nf1-and-healthy-controls-two-pathways-to-success
#7
Annet Bluschke, Maja von der Hagen, Katharina Papenhagen, Veit Roessner, Christian Beste
Neurofibromatosis Type 1 (NF1) is a monogenetic autosomal-dominant disorder with a broad spectrum of clinical symptoms and is commonly associated with cognitive deficits. Patients with NF1 frequently exhibit cognitive impairments like attention problems, working memory deficits and dysfunctional inhibitory control. The latter is also relevant for the resolution of cognitive conflicts. However, it is unclear how conflict monitoring processes are modulated in NF1. To examine this question in more detail, we used a system neurophysiological approach combining high-density ERP recordings with source localisation analyses in juvenile patients with NF1 and controls during a flanker task...
2017: NeuroImage: Clinical
https://www.readbyqxmd.com/read/28287691/effects-of-housing-on-methamphetamine-induced-neurotoxicity-and-spatial-learning-and-memory
#8
Arnold Gutierrez, Sarah A Jablonski, Robyn M Amos-Kroohs, Anna C Barnes, Michael T Williams, Charles V Vorhees
Severe stress potentiates methamphetamine (MA) neurotoxicity. However, whether moderate stress increases or decreases the neurotoxic effects of MA is unknown. We assessed the effects of MA (4 x 10 mg/kg at 2 h intervals) in combination with prior barren-cage housing in adult male Sprague-Dawley rats on monoamines and glial fibrillary acid protein (GFAP) in one cohort and spatial learning and memory in the Morris water maze in another cohort. MA reduced dopamine (DA) and serotonin (5-HT) in the neostriatum and nucleus accumbens, 5-HT in the hippocampus, and increased GFAP in neostriatum and nucleus accumbens compared with saline controls...
March 13, 2017: ACS Chemical Neuroscience
https://www.readbyqxmd.com/read/28286427/intraindividual-and-interindividual-di%C3%AF-erences-in-spontaneous-eye-blinking-relationships-to-working-memory-performance-and-frontal-eeg-asymmetry
#9
Leigh F Bacher, Shirley Retz, Courtney Lindon, Martha Ann Bell
The rate and timing of spontaneous eye blinking (SB) may be used to explore mechanisms of cognitive activity in infancy. In particular, SB rate is believed to reflect some dimensions of dopamine function; therefore, we hypothesized that SB rate would relate to working memory performance and to frontal electroencephalogram (EEG) asymmetry. Forty, 10-mo-old infants completed an A-not-B task while SB and EEG were measured throughout. We found that SB rate varied across phases of the task, variability in SB rate was positively related to working memory performance, and frontal EEG asymmetry was related to individual differences in the rate of SB...
March 2017: Infancy: the Official Journal of the International Society on Infant Studies
https://www.readbyqxmd.com/read/28284949/inhibition-of-wnt-signalling-dose-dependently-impairs-the-acquisition-and-expression-of-amphetamine-induced-conditioned-place-preference
#10
Farhana Islam, Kathleen Xu, Richard J Beninger
The mechanisms by which dopaminergic neurotransmission in the nucleus accumbens (NAc) is involved in incentive learning produced by rewarding stimuli remain unclear. Recently, Wnt signalling has been implicated in synaptic plasticity and learning and memory. Functional interactions between Wnt and dopamine (DA) signalling has been demonstrated using in vitro and tissue physiology approaches, however there remains a lack of in vivo research into the involvement of Wnt in DA-mediated learning in behaving animals...
March 8, 2017: Behavioural Brain Research
https://www.readbyqxmd.com/read/28273278/catechol-o-methyltransferase-comt-polymorphisms-modulate-working-memory-in-individuals-with-schizophrenia-and-healthy-controls
#11
Camila T Matsuzaka, Denise Christofolini, Vanessa K Ota, Ary Gadelha, Arthur A Berberian, Cristiano Noto, Diego R Mazzotti, Leticia M Spindola, Patricia N Moretti, Marilia A C Smith, Maria I Melaragno, Sintia I Belangero, Rodrigo A Bressan
Objective: Cognitive impairment is a core feature of schizophrenia, related to dopaminergic dysfunction in the prefrontal cortex (PFC). It is hypothesized that functional single nucleotide polymorphism (SNP) rs4680 of the catechol-O-methyltransferase (COMT) gene could mediate the relationship between cognition and dopamine activity in the PFC. Other COMT SNPs could also play a role. Methods: We evaluated the role of three COMT SNPs (rs737865, rs165599, and rs4680) in schizophrenia and their impact on three working memory tasks...
March 2, 2017: Revista Brasileira de Psiquiatria
https://www.readbyqxmd.com/read/28270751/understanding-the-role-of-gpcr-heteroreceptor-complexes-in-modulating-the-brain-networks-in-health-and-disease
#12
REVIEW
Dasiel O Borroto-Escuela, Jens Carlsson, Patricia Ambrogini, Manuel Narváez, Karolina Wydra, Alexander O Tarakanov, Xiang Li, Carmelo Millón, Luca Ferraro, Riccardo Cuppini, Sergio Tanganelli, Fang Liu, Malgorzata Filip, Zaida Diaz-Cabiale, Kjell Fuxe
The introduction of allosteric receptor-receptor interactions in G protein-coupled receptor (GPCR) heteroreceptor complexes of the central nervous system (CNS) gave a new dimension to brain integration and neuropsychopharmacology. The molecular basis of learning and memory was proposed to be based on the reorganization of the homo- and heteroreceptor complexes in the postjunctional membrane of synapses. Long-term memory may be created by the transformation of parts of the heteroreceptor complexes into unique transcription factors which can lead to the formation of specific adapter proteins...
2017: Frontiers in Cellular Neuroscience
https://www.readbyqxmd.com/read/28261071/trial-by-trial-modulation-of-associative-memory-formation-by-reward-prediction-error-and-reward-anticipation-as-revealed-by-a-biologically-plausible-computational-model
#13
Kristoffer C Aberg, Julia Müller, Sophie Schwartz
Anticipation and delivery of rewards improves memory formation, but little effort has been made to disentangle their respective contributions to memory enhancement. Moreover, it has been suggested that the effects of reward on memory are mediated by dopaminergic influences on hippocampal plasticity. Yet, evidence linking memory improvements to actual reward computations reflected in the activity of the dopaminergic system, i.e., prediction errors and expected values, is scarce and inconclusive. For example, different previous studies reported that the magnitude of prediction errors during a reinforcement learning task was a positive, negative, or non-significant predictor of successfully encoding simultaneously presented images...
2017: Frontiers in Human Neuroscience
https://www.readbyqxmd.com/read/28253352/dopamine-d2-receptor-and-%C3%AE-arrestin-2-mediate-amyloid-%C3%AE-elevation-induced-by-anti-parkinson-s-disease-drugs-levodopa-and-piribedil-in-neuronal-cells
#14
Jing Lu, Xiaohang Li, Qinying Wang, Gang Pei
Although levodopa is the first-line medication for the treatment of Parkinson's disease (PD) showing unsurpassable efficiency, its chronic use causes dyskinesia. Accordingly, dopamine agonists are increasingly employed as monotherapy or in combination with levodopa to reduce the risk of motor complications. It is well recognized that patients with PD often exhibit cognitive deficits. However, clinical and animal studies assessing the effects of dopaminergic medications on cognition are controversial. Amyloid-β (Aβ) is one of the major hallmarks of Alzheimer's disease (AD), leading to progressive memory loss and cognitive deficit...
2017: PloS One
https://www.readbyqxmd.com/read/28243833/current-understanding-of-methamphetamine-associated-dopaminergic-neurodegeneration-and-psychotoxic-behaviors
#15
REVIEW
Eun-Joo Shin, Duy-Khanh Dang, The-Vinh Tran, Hai-Quyen Tran, Ji Hoon Jeong, Seung-Yeol Nah, Choon-Gon Jang, Kiyofumi Yamada, Toshitaka Nabeshima, Hyoung-Chun Kim
Clinical and preclinical studies have indicated that chronic methamphetamine (MA) use is associated with extensive neurodegeneration, psychosis, and cognitive impairment. Evidence from animal models has suggested a considerable role of excess dopamine or glutamate, oxidative stress, neuroinflammation, and apoptosis in MA-induced neurotoxicity, and that protein kinase Cδ might mediate the interaction among these factors. In addition, the relatively long-lasting and recurrent nature of MA psychosis has been reproduced in animals treated with various dosing regimens of MA, which have shown behavioral sensitization, sociability deficits, and impaired prepulse inhibition...
February 28, 2017: Archives of Pharmacal Research
https://www.readbyqxmd.com/read/28223337/functional-expression-of-dopamine-d2-receptor-is-regulated-by-tetraspanin-7-mediated-postendocytic-trafficking
#16
Seol-Ae Lee, Yeongjun Suh, Saebom Lee, Jaehoon Jeong, Soo Jeong Kim, So Jung Kim, Sang Ki Park
The dopaminergic system plays an essential role in various functions of the brain, including locomotion, memory, and reward, and the deregulation of dopaminergic signaling as a result of altered functionality of dopamine D2 receptor (DRD2) is implicated in multiple neurologic and psychiatric disorders. Tetraspanin-7 (TSPAN7) is expressed to variable degrees in different tissues, with the highest level in the brain, and multiple mutations in TSPAN7 have been implicated in intellectual disability. Here, we tested the hypothesis that TSPAN7 may be a binding partner of DRD2 that is involved in the regulation of its functional activity...
February 21, 2017: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/28219076/effect-of-n-benzylpiperazine-its-metabolite-n-benzylethylenediamine-and-its-disubstituted-analogue-n-n-dibenzylpiperazine-on-the-acquisition-formation-and-consolidation-of-memory-in-mice
#17
Juan Carlos Castillo-Hernández, Josué A Velázquez-Moyado, Adelfo Reyes-Ramírez, Elena G Ramírez-López, Martín González-Andrade, Andrés Navarrete
BACKGROUND: N-benzylpiperazine (BZP) belongs to a class of piperazine derivatives (PZDs) that have emerged as recreational drugs. These compounds increase the release of dopamine and serotonin. BZP mimics the psychoactive effects of 3,4-methylenedioxymethylamphetamine. BZP is metabolized to N-benzylethylenediamine (BEDA) and benzylamine. The compound N,N'-dibenzylpiperazine (DBZP) is obtained as a byproduct during the synthesis of BZP. Some PZDs have shown effects on memory; however, there are no previous reports on the activity of BZP, BEDA, and DBZP on memory or on a description of their neuropharmacological profile...
February 21, 2017: Pharmacology
https://www.readbyqxmd.com/read/28216334/crocins-the-active-constituents-of-crocus-sativus-l-counteracted-apomorphine-induced-performance-deficits-in-the-novel-object-recognition-task-but-not-novel-object-location-task-in-rats
#18
Nikolaos Pitsikas, Petros A Tarantilis
Schizophrenia is a chronic mental disease that affects nearly 1% of the population worldwide. Several lines of evidence suggest that the dopaminergic (DAergic) system might be compromised in schizophrenia. Specifically, the mixed dopamine (DA) D1/D2 receptor agonist apomorphine induces schizophrenia-like symptoms in rodents, including disruption of memory abilities. Crocins are among the active components of saffron (dried stigmas of Crocus sativus L. plant) and their implication in cognition is well documented...
February 17, 2017: Neuroscience Letters
https://www.readbyqxmd.com/read/28214749/impairment-in-the-mesohippocampal-dopamine-circuit-following-exposure-to-the-brominated-flame-retardant-hbcdd
#19
Camille Pham-Lake, Elizabeth B Aronoff, Chad R Camp, Aimee Vester, Sam J Peters, W Michael Caudle
Many chemicals have been used to increase the safety of consumer products by reducing their flammability and risk for ignition. Recent focus on brominated flame retardants, such as polybrominated diphenyl ethers (PBDEs) has shown them to contribute to neurobehavioral deficits in children, including learning and memory. As the manufacture and use of PBDEs have been reduced, replacement chemicals, such as hexabromocyclododecane (HBCDD) have been substituted. Our current study evaluated the neurotoxicity of HBCDD, concentrating on dopaminergic innervation to the hippocampus...
March 2017: Environmental Toxicology and Pharmacology
https://www.readbyqxmd.com/read/28212942/activation-of-type-4-dopaminergic-receptors-in-the-prelimbic-area-of-medial-prefrontal-cortex-is-necessary-for-the-expression-of-innate-fear-behavior
#20
Macarena D Vergara, Victor N Keller, José A Fuentealba, Katia Gysling
The prelimbic area (PL) of the medial Prefrontal cortex (mPFC) is involved in the acquisition and expression of conditioned and innate fear. Both types of fear share several neuronal pathways. It has been documented that dopamine (DA) plays an important role in the regulation of aversive memories in the mPFC. The exposure to an aversive stimulus, such as the smell of a predator odor or the exposure to footshock stress is accompanied by an increase in mPFC DA release. Evidence suggests that the type 4 dopaminergic receptor (D4R) is the molecular target through which DA modulates fear expression...
May 1, 2017: Behavioural Brain Research
keyword
keyword
106922
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"