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https://www.readbyqxmd.com/read/29772920/a-contagious-disorder-folie-%C3%A3-deux-and-dementia
#1
Gabriele Cipriani, Noha Abdel-Gawad, Sabrina Danti, Mario Di Fiorino
BACKGROUND: Folie à deux is a clinical condition that was first described in 19th century. It is a psychotic disorder in which two closely associated individuals share a similar delusional system. OBJECTIVES: The aim of this article is to review the nosological significance of folie à deux and to explore the disorder among patients with dementia. METHODS: Medline and Google Scholar searches were conducted for relevant articles, chapters, and books published before 2017...
January 1, 2018: American Journal of Alzheimer's Disease and Other Dementias
https://www.readbyqxmd.com/read/29770363/the-multifaceted-clinical-presentation-of-vcp-proteinopathy-in-a-greek-family
#2
George K Papadimas, George P Paraskevas, Thomas Zambelis, Chrisostomos Karagiaouris, Mara Bourbouli, Anastasia Bougea, Maggie C Walter, Nicolas U Schumacher, Sabine Krause, Elisabeth Kapaki
VCP-proteinopathy is a multisystem neurodegenerative disorder caused by mutations in valosin containing protein. Here, we report the first Greek case of VCP-proteinopathy in a 62 year old patient with a slowly progressing muscular weakness since his mid-40s and a severe deterioration during the last year. He also manifested dementia with prominent neuropsychiatric symptoms, including aggression, apathy, palilalia and obsessions. Brain MRI revealed frontal atrophy, while muscle MRI showed diffuse muscle atrophy...
December 2017: Acta Myologica: Myopathies and Cardiomyopathies: Official Journal of the Mediterranean Society of Myology
https://www.readbyqxmd.com/read/29769783/trichotillomania-ranging-from-ritual-to-illness-and-as-a-rare-clinical-manifestation-of-frontotemporal-dementia-review-of-literature-and-case-report
#3
Thomas Gregor Issac, Ashay Vivek Telang, Sadanandavalli Retnaswami Chandra
Frontotemporal dementia (FTD) is the most common form of dementia in the younger age group and often exists with comorbid obsessions and compulsions in up to 80% of the patients. Trichotillomania or compulsive "hair-pulling" disorder is a rare manifestation of FTD and is a poorly evaluated symptom in this condition. The release of "grooming functions" due to frontal disinhibition is often attributed to the evolutionary perspective; however, recent findings also implicate the role of neurotransmitter dysfunction...
March 2018: International Journal of Trichology
https://www.readbyqxmd.com/read/29755512/proton-pump-inhibitors-and-dementia-physiopathological-mechanisms-and-clinical-consequences
#4
REVIEW
Gloria Ortiz-Guerrero, Diana Amador-Muñoz, Carlos Alberto Calderón-Ospina, Daniel López-Fuentes, Mauricio Orlando Nava Mesa
Alzheimer's disease (AD) is the most common type of dementia, mainly encompassing cognitive decline in subjects aged ≥65 years. Further, AD is characterized by selective synaptic and neuronal degeneration, vascular dysfunction, and two histopathological features: extracellular amyloid plaques composed of amyloid beta peptide (A β ) and neurofibrillary tangles formed by hyperphosphorylated tau protein. Dementia and AD are chronic neurodegenerative conditions with a complex physiopathology involving both genetic and environmental factors...
2018: Neural Plasticity
https://www.readbyqxmd.com/read/29751937/beyond-thiamine-treatment-for-cognitive-impairment-in-korsakoff-s-syndrome
#5
REVIEW
Justin M Johnson, Valerie Fox
BACKGROUND: Wernicke's encephalopathy is a condition whose treatment many consultation-liaison psychiatrists know quite well. Less clear, however, is the treatment of its dementia disorder descendent, the Korsakoff's syndrome (KS). OBJECTIVE: This article seeks to review treatment options and provide recommendations for consultation-liaison psychiatrists treating cognitive impairment in KS. METHODS: In this nonsystematic review, we reviewed PubMed, CINAHL Plus, and Google Scholar for published reports and studies regarding treatment of KS...
March 27, 2018: Psychosomatics
https://www.readbyqxmd.com/read/29746915/cognition-and-dementia-related-adverse-effects-with-sacubitril-valsartan-analysis-of-the-fda-adverse-event-report-system-database
#6
Amichai Perlman, Bruria Hirsh Raccah, Ilan Matok, Mordechai Muszkat
BACKGROUND: As neprilysin is involved in the degradation of amyloid-beta, there is concern the angiotensin-neprilysin inhibitor, sacubitril-valsartan, could increase the risk for dementia. METHODS: We analyzed adverse event cases submitted to the FDA adverse event report system between July 2015 and March 2017. Cognition and dementia related adverse event cases were defined using broad and narrow structured medical queries. RESULTS: During the period evaluated, 9,004 adverse event reports (out of a total of 2,249,479) involved the use of sacubitril-valsartan...
May 7, 2018: Journal of Cardiac Failure
https://www.readbyqxmd.com/read/29746914/cognition-and-dementia-related-adverse-effects-with-sacubitril-valsartan-analysis-of-the-fda-adverse-event-report-system-database
#7
Amichai Perlman, Bruria Hirsh Raccah, Ilan Matok, Mordechai Muszkat
BACKGROUND: As neprilysin is involved in the degradation of amyloid-beta, there is concern the angiotensin-neprilysin inhibitor, sacubitril-valsartan, could increase the risk for dementia. METHODS: We analyzed adverse event cases submitted to the FDA adverse event report system between July 2015 and March 2017. Cognition and dementia related adverse event cases were defined using broad and narrow structured medical queries. RESULTS: During the period evaluated, 9,004 adverse event reports (out of a total of 2,249,479) involved the use of sacubitril-valsartan...
May 7, 2018: Journal of Cardiac Failure
https://www.readbyqxmd.com/read/29745686/does-incipient-dementia-explain-normal-cognitive-decline-determinants-lothian-birth-cohort-1921
#8
Ruth A Sibbett, Tom C Russ, Alison Pattie, John M Starr, Ian J Deary
The presence of an apolipoprotein E (APOE) ε4 allele, lower physical fitness, smoking, and lower serum vitamin B-12 have been reported as contributing to poorer cognitive function in LBC1921 at age 79, after adjusting for childhood intelligence. Because incident dementia was not previously ascertained within LBC1921, it is possible that preclinical or unrecognized cases at age 79 influenced findings. Dementia cases arising over approximately 16 years of follow-up were determined by a consensus using evidence from electronic medical records, death certificates, and clinical reviews...
May 10, 2018: Psychology and Aging
https://www.readbyqxmd.com/read/29736355/juvenile-myoclonic-epilepsy-presenting-with-neurocognitive-impairment-a-case-report
#9
Sarfraz Mahesar, Hira F Akbar, Husnain Abid, Rabia Sana
Juvenile myoclonic epilepsy (JME) is a genetically and clinically diverse disorder which is characterized by myoclonic jerks, usually after awakening from sleep. It affects both genders equally and manifests during the second decade of life. The various precipitating factors include stress, light, sleep deprivation, and alcohol. A history of morning clumsiness supported by typical electroencephalography (EEG) findings, together with a normal clinical examination all point towards a diagnosis of JME. We present the case of a nine-year-old girl who presented with cognitive dysfunction in addition to myoclonic jerks...
March 5, 2018: Curēus
https://www.readbyqxmd.com/read/29736079/nonpharmacological-methods-in-managing-patients-with-dementia-in-a-tertiary-care-hospital
#10
Nisha Mani Pandey, Shailendra Mohan Tripathi, Bhupendra Singh, Sarvada Chandra Tiwari
Management of dementia is very crucial. Nonpharmacological methods (NPM) are well appreciated and encouraged to be used as first-line treatment for managing elderly patients with dementia (PwD). The present case reports aimed to share the strategies of NPM for managing PwD. NPM requires a structured blueprint to record, follow-up, and monitor the outcomes. A structured proforma has been developed in the department. After getting all the basic information from the patient, needed assessments are being done by the concerned team member to identify and rate the level of severity of the problem, and specific NPM strategies are being provided...
January 2018: Indian Journal of Psychiatry
https://www.readbyqxmd.com/read/29731390/psychological-factors-related-to-nurses-intentions-to-initiate-an-antipsychotic-or-psychosocial-intervention-with-nursing-home-residents
#11
Brian M Ludwin, Suzanne Meeks
This study examined the validity of a psychological model for understanding nursing home providers' treatment choices when managing challenging dementia-related behaviors. Ninety-nine nurses from 26 long-term care facilities responded to a case study with their intentions to initiate an antipsychotic or psychosocial intervention and completed self-report measures of their attitudes, descriptive norms, self-efficacy, and outcome expectancies. The multi-level modeling results demonstrated that nurses with more positive outcome expectancies for the effect of an antipsychotic on resident behavior, and those with more positive attitudes towards antipsychotics, had greater intentions to initiate an antipsychotic...
May 3, 2018: Geriatric Nursing
https://www.readbyqxmd.com/read/29723176/the-dunedin-dementia-risk-awareness-project-a-convenience-sample-of-general-practitioners
#12
Yoram Barak, Charlene Rapsey, Dana Fridman, Kate Scott
AIMS: Recent recommendations of US and UK governmental and academic agencies suggest that up to 35% of dementia cases are preventable. We aimed to appraise general practitioners' (GPs) awareness of risk and protective factors associated with dementia and their intentions to act within the context of the Health Beliefs Model. METHODS: We canvassed degree of dementia awareness, using the modified Lifestyle for Brain Health (LIBRA) scale among a convenience sample of local GPs...
May 4, 2018: New Zealand Medical Journal
https://www.readbyqxmd.com/read/29721853/uncommon-and-or-bizarre-features-of-dementia-part-iii
#13
REVIEW
Gabriele Cipriani, Angelo Nuti, Sabrina Danti, Lucia Picchi, Mario Di Fiorino
Clinical neurologists have long recognized that dementia can present as atypical or variant syndromes/symptoms. This study aimed at describing uncommon or bizarre symptoms/syndromes observed in patients suffering from dementia. Medline and Google scholar searches were conducted for relevant articles, chapters, and books published before 2018. Search terms used included compulsion, dementia, extracampine hallucination, disordered gambling, humour, and obsession. Publications found through this indexed search were reviewed for further relevant references...
May 3, 2018: Acta Neurologica Belgica
https://www.readbyqxmd.com/read/29719485/accuracy-of-quantitative-positron-emission-tomography-assessment-for-differentiating-cerebral-age-related-from-pathological-amyloid-deposition-a-preliminary-report-from-a-case-series-study
#14
Fulvio Lauretani, Livia Ruffini, Andrea Ticinesi, Antonio Nouvenne, Marcello Maggio, Tiziana Meschi
Previous observational studies using old qualitative methods have not clarified the role of amyloid positron emission tomography (PET) in the assessment of dementia. Given the moderately positive predictive value, the presence of amyloid deposition does not necessarily imply the diagnosis of dementia. Conversely, the absence of amyloid PET deposition has been shown to be useful in excluding the neurodegenerative pathology, irrespective of the aging process. We describe the clinical application of new innovative software recently developed to increase the sensitivity of this technique and to discriminate pathological deposition of cerebral amyloid from the age-related changes, reporting preliminary findings from a case-series study...
April 2018: World Journal of Nuclear Medicine
https://www.readbyqxmd.com/read/29712690/support-for-midlife-anxiety-diagnosis-as-an-independent-risk-factor-for-dementia-a-systematic-review
#15
Amy Gimson, Marco Schlosser, Jonathan D Huntley, Natalie L Marchant
OBJECTIVES: Anxiety is an increasingly recognised predictor of cognitive deterioration in older adults and in those with mild cognitive impairment. Often believed to be a prodromal feature of neurodegenerative disease, anxiety may also be an independent risk factor for dementia, operationally defined here as preceding dementia diagnosis by ≥10 years. DESIGN: A systematic review of the literature on anxiety diagnosis and long-term risk for dementia was performed following published guidelines...
April 30, 2018: BMJ Open
https://www.readbyqxmd.com/read/29709939/a-case-of-fatal-familial-insomnia-initially-developing-parkinsonism-mimicking-dementia-with-lewy-bodies
#16
Takuya Fukuoka, Yoshihiko Nakazato, Masaomi Yamamoto, Akifumi Miyake, Takashi Mitsufuji, Toshimasa Yamamoto
We report a rare case of fatal familial insomnia in a 58-year-old man who initially developed parkinsonism, secondary dementia, and visual hallucinations that were suspected to be due to dementia with Lewy bodies. We evaluated the function of the striatum via dopamine transporter SPECT using 123 I-ioflupane and found marked presynaptic dopamine dysfunction in the bilateral striatum. This is the first reported case in which the initial symptom of fatal familial insomnia was parkinsonism and in which the dopamine transporter function was evaluated by DAT SPECT...
April 27, 2018: Internal Medicine
https://www.readbyqxmd.com/read/29703157/a-pathway-from-low-socioeconomic-status-to-dementia-in-japan-results-from-the-toyama-dementia-survey
#17
Nobue Nakahori, Michikazu Sekine, Masaaki Yamada, Takashi Tatsuse, Hideki Kido, Michio Suzuki
BACKGROUND: The association between low socioeconomic status (SES) and dementia is reportedly mediated by lifestyle-related diseases (i.e., diabetes) in European countries and the United States; however, in Japan, the link between low SES and dementia has not been investigated. This study evaluated the possibility of a mediating role of lifestyle-related diseases in the relationship between low SES and dementia in Japan. METHODS: A retrospective case-control study design, with data from the Toyama Dementia Survey, Japan, was used...
April 27, 2018: BMC Geriatrics
https://www.readbyqxmd.com/read/29701155/dietary-fat-intake-and-risk-of-alzheimer-s-disease-and-dementia-a-meta-analysis-of-cohort-studies
#18
Yue Ruan, Jun Tang, Xiaofei Guo, Kelei Li, Duo Li
BACKGROUND: Epidemiological studies showed that dietary fat intake was associated with Alzheimer's disease (AD) and dementia risk, however, the association remain inconsistent. This meta-analysis aimed to systematically examine the association of dietary fat intake with AD and dementia risk. METHODS: We have systematically searched PubMed, Embase and the Cochrane Library up to May 1st 2017. Prospective cohort studies were included if they reported on the association of dietary fat intake with AD and dementia risk...
April 27, 2018: Current Alzheimer Research
https://www.readbyqxmd.com/read/29699515/creutzfeldt-jakob-disease-with-alzheimer-pathology-presenting-with-status-epilepticus-following-repeated-partial-seizures-a-case-report-and-literature-review
#19
Keita Miyake, Takashi Hara, Etsuko Oshima, Kiyohiro Kawada, Hideki Ishizu, Yuko Yamauchi, Katsuya Satoh, Tetsuyuki Kitamoto, Shintaro Takenoshita, Seishi Terada, Norihito Yamada
BACKGROUND: Creutzfeldt-Jakob disease (CJD) is a fatal neurodegenerative disease. Common first symptoms are dementia, cerebellar ataxia, visual disturbance, and psychiatric symptoms. Seizure as the first symptom of CJD is a very rare finding. CASE PRESENTATION: We experienced an elderly woman who presented initially with status epilepticus following repeated partial seizures in the course of Alzheimer disease (AD) dementia. Anti-convulsive therapy had no effect...
April 25, 2018: BMC Neurology
https://www.readbyqxmd.com/read/29697522/living-with-dementia-in-correctional-settings-a-case-report
#20
Shelley Peacock, Alexandra Hodson, Rhoda MacRae, Cindy Peternelj-Taylor
The prison population is aging at an alarming rate and many older persons have the potential to develop dementia while in prison. This case report aims to explore the needs of older people living with dementia in prison and discusses the interventions that exist to address these needs. As the condition progresses, persons with dementia become increasingly reliant on the support of others for their health and well-being because of the increasing complexity of physical healthcare and psychosocial needs. Very few interventions are cited in the research literature regarding the use, acceptability, and/or effectiveness of programming for people living with dementia in prison...
April 24, 2018: Journal of Forensic Nursing
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